Acacetin (BioDeep_00000000251)

natural product human metabolite PANOMIX_OTCML-2023

代谢物信息卡片

4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-2-(4-METHOXYPHENYL)-

化学式: C16H12O5 (284.0684702)
中文名称: 金合欢素, 刺槐素, 刺槐黄素
谱图信息: 最多检出来源 Viridiplantae(plant) 0.8%

分子结构信息

SMILES: C1(O)=CC2OC(C3C=CC(OC)=CC=3)=CC(=O)C=2C(O)=C1
InChI: InChI=1/C16H12O5/c1-20-11-4-2-9(3-5-11)14-8-13(19)16-12(18)6-10(17)7-15(16)21-14/h2-8,17-18H,1H3

描述信息

5,7-dihydroxy-4-methoxyflavone is a monomethoxyflavone that is the 4-methyl ether derivative of apigenin. It has a role as an anticonvulsant and a plant metabolite. It is a dihydroxyflavone and a monomethoxyflavone. It is functionally related to an apigenin. It is a conjugate acid of a 5-hydroxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-7-olate.
Acacetin is a natural product found in Verbascum lychnitis, Odontites viscosus, and other organisms with data available.
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research[1][2].
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research[1][2].

同义名列表

54 个代谢物同义名

4H-1-BENZOPYRAN-4-ONE, 5,7-DIHYDROXY-2-(4-METHOXYPHENYL)-; 5,7-dihydroxy-2-(4-methoxyphenyl)-4h-1-benzopyran-4-one; 2-(4-Methoxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one,7-dihydroxy-2-(4-methoxyphenyl)-; 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one #; 5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one; 5,7-Dihydroxy-2-(4-methoxyphenyl)-4-benzopyrone; 5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one; 5-18-04-00575 (Beilstein Handbook Reference); Flavone, 5,7-dihydroxy-4-methoxy-; Flavone,7-dihydroxy-4-methoxy-; 5,7-Dihydroxy-4-methoxyflavone; 4-Methoxy-5,7-dihydroxyflavone; WLN: T66 BO EVJ CR DO1& GQ IQ; Acacetin, analytical standard; DANYIYRPLHHOCZ-UHFFFAOYSA-N; 5,7-Dioxy-4-methoxyflavone; Apigenin 4-dimethyl ether; Acacetin, >=97.0\\% (HPLC); Apigenin 4-methyl ether; APIGENIN-4-METHYL ETHER; Apisenin 4-methyl ether; 4-O-Methylapigenin; Prestwick2_000695; 4-Methoxyapigenin; Prestwick0_000695; Prestwick1_000695; Prestwick3_000695; 4-Methylapigenin; Spectrum5_000930; BCBcMAP01_000082; UNII-KWI7J0A2CC; Buddleoflavonol; 5,7-Dihydroxy-4; ACACETIN [MI]; BPBio1_000935; DivK1c_000878; KBio2_000595; Prestwick_49; KBio2_003163; KBio2_005731; KBio1_000878; IDI1_000878; Linarigenin; Linarisenin; SMP1_000001; KWI7J0A2CC; Acaceztin; Akatsetin; Acacetine; Acacetin; ACAETIN; ACAC; 5,7-Dihydroxy-4'-methoxyflavone

数据库引用编号

28 个数据库交叉引用编号

ChEBI: CHEBI:15335
KEGG: C01470
PubChem: 5280442
HMDB: HMDB0132457
Metlin: METLIN48899
ChEMBL: CHEMBL243664
Wikipedia: Acacetin
LipidMAPS: LMPK12110468
MeSH: acacetin
ChemIDplus: 0000480444
MetaCyc: CPD-1095
chemspider: 4444099
CAS: 480-44-4
MoNA: PS084101
MoNA: PS084105
MoNA: PR020028
MoNA: PS084103
MoNA: PS084102
MoNA: PS084108
MoNA: PS084107
MoNA: PS084104
medchemexpress: HY-N0451
PMhub: MS000010233
PubChem: 4645
KNApSAcK: C00003820
3DMET: B00296
NIKKAJI: J6.166B
RefMet: Acacetin

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

151 个相关的物种来源信息

39269 - Agastache foeniculum: 10.1016/0305-1978(84)90067-X
672814 - Agastache nepetoides: 10.1016/0305-1978(84)90067-X
39271 - Agastache rugosa:
672816 - Agastache scrophulariifolia: 10.1016/0305-1978(84)90067-X
268936 - Agastache urticifolia: 10.1016/0305-1978(84)90067-X
102750 - Ageratina altissima:
3517 - Alnus glutinosa: 10.1016/0305-1978(91)90099-L
109063 - Alnus japonica: 10.1016/0031-9422(74)85049-1
183227 - Anoda cristata: 10.1016/J.JEP.2014.11.052
7460 - Apis mellifera: 10.3390/IJMS15022327
414592 - Argyrochosma nivea: 10.1016/0031-9422(93)85457-3
2065848 - Arnica amplexicaulis: 10.1016/S0031-9422(00)83767-X
436195 - Arnica chamissonis:
436210 - Arnica parryi: 10.1016/S0031-9422(00)83767-X
72333 - Artemisia afra: 10.1002/PTR.1066
1287603 - Artemisia diffusa: 10.1515/ZNC-1995-5-604
72342 - Artemisia fragrans: 10.1016/0305-1978(91)90084-D
401898 - Artemisia gmelinii:
72329 - Artemisia herba-alba: 10.1016/S0031-9422(00)84593-8
265784 - Artemisia iwayomogi: 10.1515/ZNC-1995-5-604
205369 - Artemisia judaica: 10.1016/S0031-9422(00)84593-8
1177124 - Artemisia kurramensis: 10.1021/NP800643N
1227633 - Artemisia minor:
72347 - Artemisia molinieri: 10.1515/ZNC-1995-5-604
72348 - Artemisia monosperma: 10.1016/S0031-9422(00)84593-8
1338417 - Artemisia oliveriana: 10.1016/0305-1978(91)90084-D
223870 - Artemisia princeps: 10.1055/S-2006-957714
1811969 - Artemisia vestita: 10.1021/NP800643N
2707406 - Baccharis darwinii: 10.1016/S0031-9422(00)80758-X
72900 - Baccharis dracunculifolia:
1654447 - Baccharis patagonica: 10.1021/NP50055A026
2707510 - Baccharis pseudovaccinioides: 10.1515/ZNC-1986-1-214
427666 - Baccharis salicifolia: 10.1515/ZNC-1986-1-214
191149 - Bahiopsis reticulata: 10.1016/0305-1978(89)90096-3
230198 - Balsamorhiza deltoidea: 10.1016/0031-9422(89)80041-X
3505 - Betula pendula: 10.1016/S0021-9673(97)00900-X
38787 - Betula pubescens: 10.1016/S0021-9673(97)00900-X
74351 - Biebersteinia orphanidis: 10.1016/S0031-9422(00)00355-1
28540 - Buddleja davidii: 10.1016/0378-8741(84)90075-8
714454 - Buddleja officinalis:
714454 - Buddleja officinalis Maxim.: -
1125166 - Calea jamaicensis:
1475378 - Calea ternifolia:
2813830 - Callicarpa pilosissima:
47643 - Caragana frutex: 10.1007/BF00597817
4222 - Carthamus tinctorius:
1048535 - Centaurea cuneifolia:
363441 - Centaurea pallescens: 10.1055/S-2006-962790
103745 - Chromolaena odorata:
316753 - Chrozophora tinctoria: 10.1016/0305-1978(90)90051-G
344871 - Chrysanthemum boreale: 10.1007/BF02979135
146995 - Chrysanthemum indicum:
146995 - Chrysanthemum indicum L.: -
146996 - Chrysanthemum lavandulifolium: 10.1007/BF02979135
516546 - Cirsium japonicum: 10.1007/S10600-011-9904-6
297476 - Cirsium oleraceum: 10.1007/BF00569015
2595066 - Cirsium rhinoceros: 10.1007/BF02976657
191224 - Cistus creticus:
335173 - Cistus ladanifer:
335179 - Cistus laurifolius: 10.1016/S0021-9673(01)88918-4
558547 - Citrus deliciosa: 10.1016/0021-9673(94)89051-X
85571 - Citrus reticulata: 10.1016/0021-9673(94)89051-X
55188 - Citrus unshiu: 10.1016/0021-9673(94)89051-X
507393 - Combretum caffrum: 10.1021/NP50051A008
1407630 - Crocus heuffelianus: 10.1515/ZNC-1984-1-204
323701 - Crocus laevigatus: 10.1515/ZNC-1984-1-204
1150283 - Cunila lythrifolia: 10.1016/S0031-9422(00)97769-0
381256 - Didymoglossum reptans: 10.1002/J.1537-2197.1996.TB13914.X
2024912 - Dracocephalum multicaule: 10.1007/BF00630447
53719 - Eclipta prostrata L.: -
662901 - Elsholtzia ciliata: 10.1246/NIKKASHI1948.88.7_763
79350 - Eriodictyon sessilifolium: 10.1515/ZNC-1988-5-603
13533 - Fouquieria splendens: 10.1515/ZNC-1994-9-1022
353936 - Fridericia chica: 10.1016/S0031-9422(01)00038-3
399105 - Frullania teneriffae: 10.1515/ZNC-1995-5-603
180103 - Garcinia cowa: 10.1021/NP8006364
1220707 - Garcinia gummi-gutta: 10.1021/NP8006364
469930 - Garcinia kola: 10.1021/NP50023A026
3311 - Ginkgo biloba:
662482 - Grindelia camporum:
1114741 - Grindelia hirsutula:
983334 - Gymnocarpium robertianum: 10.1016/S0031-9422(97)01003-0
2816892 - Heteroplexis microcephala: 10.1021/NP900213W
9606 - Homo sapiens: -
557660 - Inula salsoloides: 10.1002/HLCA.201000195
1548348 - Lepidaploa rufogrisea: 10.1016/S0031-9422(96)00714-5
483811 - Leucas aspera: 10.1248/CPB.51.595
2126591 - Ligularia amplexicaulis: 10.1016/S0031-9422(00)83767-X
1138066 - Linaria aeruginea: 10.1016/S0031-9422(00)97311-4
1315793 - Linaria kurdica: 10.1007/BF00568249
2500775 - Linaria macroura: 10.1007/BF00579788
2792409 - Linaria sessilis: 10.1007/BF00568249
28959 - Lupinus texensis:
594549 - Lychnophora ericoides: 10.1002/(SICI)1099-1565(200003/04)11:2<69::AID-PCA499>3.0.CO;2-Y
1720382 - Lycopus asper: 10.1248/CPB.58.394
516551 - Lycopus lucidus: 10.1248/CPB.58.394
1611021 - Meehania fargesii: 10.1248/CPB.58.696
190902 - Mentha aquatica: 10.1016/S0031-9422(97)01042-X
292239 - Mentha arvensis: 10.1016/S0031-9422(97)01042-X
294733 - Mentha canadensis: 10.1016/S0031-9422(97)01042-X
38859 - Mentha longifolia: 10.1016/S0031-9422(97)01042-X
29719 - Mentha spicata: 10.1016/S0031-9422(97)01042-X
1898725 - Microglossa pyrifolia: 10.1515/ZNC-2002-11-1212
306386 - Micromeria cristata: 10.1016/0305-1978(91)90088-H
751838 - Micromeria croatica: 10.1016/0305-1978(91)90088-H
306391 - Micromeria graeca: 10.1016/0305-1978(91)90088-H
306395 - Micromeria juliana: 10.1016/0305-1978(91)90088-H
271002 - Mimetanthe pilosa: 10.1515/ZNC-2000-1-203
1424733 - Mirabilis viscosa: 10.1016/S0305-1978(96)00081-6
1898873 - Mosla scabra: 10.1016/J.FITOTE.2009.12.005
500426 - Notholaena greggii:
500430 - Notholaena rigida: 10.1021/NP50050A009
40964 - Notholaena rosei: 10.1021/NP50050A009
204141 - Ocimum americanum: 10.1016/S0031-9422(00)00439-8
39350 - Ocimum basilicum:
1005697 - Odontites viscosus: 10.1515/ZNC-2000-1-203
92915 - Onopordum acanthium: 10.1055/S-2006-962793
297478 - Onopordum illyricum: 10.1021/NP990098Z
369397 - Picea neoveitchii: 10.1016/J.PHYTOCHEM.2011.01.018
33090 - Plants: -
130299 - Plazia daphnoides: 10.1016/0031-9422(88)80695-2
120615 - Podocarpus fasciculus: 10.1248/CPB.56.585
1081573 - Pogostemon stellatus: 10.1016/J.FITOTE.2009.07.004
482945 - Populus grandidentata: 10.1515/ZNC-1987-9-1004
113636 - Populus tremula: 10.1007/BF00599014
3693 - Populus tremuloides: 10.1139/V09-151
4876 - Rhizophagus intraradices: 10.1016/J.PHYTOCHEM.2004.06.005
35938 - Robinia pseudoacacia: 10.1076/1388-0209(200007)38:3;1-S;FT229
21880 - Salvia: 10.1021/NP50048A050
207754 - Salvia dorrii: 10.1515/ZNC-1992-9-1025
38869 - Salvia sclarea: 10.1016/S0031-9422(00)90474-6
1933769 - Salvia yosgadensis:
107240 - Scoparia dulcis:
2844931 - Seriphidium transiliense: 10.1007/BF00595086
4170 - Striga asiatica: 10.1021/NP50039A027
128002 - Tanacetum vulgare:
372411 - Tetraria capillaris: 10.1016/S0031-9422(00)84889-X
1209863 - Teucrium japonicum: 10.1016/0031-9422(91)83494-6
1914849 - Tricostularia neesii: 10.1016/S0031-9422(00)84889-X
3899 - Trifolium repens: 10.1016/J.PHYTOCHEM.2004.06.005
78479 - Trollius Chinensis: -
329212 - Turnera diffusa: 10.1021/NP060253R
386441 - Veratrum dahuricum: 10.1007/S10600-007-0233-8
1000433 - Verbascum lychnitis: 10.1007/BF00564831
413483 - Vitex limonifolia: 10.1515/ZNC-2008-5-611
49994 - Volkameria inermis:
72655 - Xanthorrhoea australis: 10.1071/CH9740331
751879 - Ziziphora clinopodioides: 10.1016/J.FITOTE.2011.11.023
13422 - 菊花: -
33090 - 金合欢: -
569774 - 金线莲: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Jing Li, Xianmei Zhong, Yueshui Zhao, Jing Shen, Zhangang Xiao, Chalermchai Pilapong. Acacetin inhibited non-small-cell lung cancer (NSCLC) cell growth via upregulating miR-34a in vitro and in vivo. Scientific reports. 2024 01; 14(1):2348. doi: 10.1038/s41598-024-52896-6. [PMID: 38287075]
Álvaro Pérez-Valero, Suhui Ye, Patricia Magadán-Corpas, Claudio J Villar, Felipe Lombó. Metabolic engineering in Streptomyces albidoflavus for the biosynthesis of the methylated flavonoids sakuranetin, acacetin, and genkwanin. Microbial cell factories. 2023 Nov; 22(1):234. doi: 10.1186/s12934-023-02247-3. [PMID: 37964284]
Jian-Ping Deng, Xin Liu, Yue Li, Shi-Hao Ni, Shu-Ning Sun, Xiao-Lu Ou-Yang, Xiao-Han Ye, Ling-Jun Wang, Lu Lu. Drug vector representation and potential efficacy prediction based on graph representation learning and transcriptome data: Acacetin from traditional Chinese Medicine model. Journal of ethnopharmacology. 2023 Apr; 305(?):115966. doi: 10.1016/j.jep.2022.115966. [PMID: 36572325]
Yanan Zhang, Qianqian Huang, Xiaowei Xiong, Tingting Yin, Sheng Chen, Wanwan Yuan, Guohua Zeng, Qiren Huang. Acacetin alleviates energy metabolism disorder through promoting white fat browning mediated by AC-cAMP pathway. Journal of physiology and biochemistry. 2023 Feb; ?(?):. doi: 10.1007/s13105-023-00947-3. [PMID: 36781604]
Zhe Jiang, Hao Sun, Jiaen Miao, Qiyu Sheng, Jia Xu, Zhe Gao, Xie Zhang, Yufei Song, Kuihao Chen. The natural flavone acacetin protects against high-fat diet-induced lipid accumulation in the liver via the endoplasmic reticulum stress/ferroptosis pathway. Biochemical and biophysical research communications. 2023 01; 640(?):183-191. doi: 10.1016/j.bbrc.2022.12.014. [PMID: 36516527]
Mahima Singh, Ajay Guru, Gokul Sudhakaran, Raman Pachaiappan, Shahid Mahboob, K A Al-Ghanim, F Al-Misned, Annie Juliet, Muthukaruppan Gobi, Jesu Arokiaraj. Copper sulfate induced toxicological impact on in-vivo zebrafish larval model protected due to acacetin via anti-inflammatory and glutathione redox mechanism. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Dec; 262(?):109463. doi: 10.1016/j.cbpc.2022.109463. [PMID: 36087706]
Jing Mu, Hong Chen, Mengyi Ye, Xiaoxia Zhang, Huisheng Ma. Acacetin resists UVA photoaging by mediating the SIRT3/ROS/MAPKs pathway. Journal of cellular and molecular medicine. 2022 08; 26(16):4624-4628. doi: 10.1111/jcmm.17415. [PMID: 35765710]
Fei Song, Yi-Jie Mao, Yu Hu, Shan-Shan Zhao, Ruiying Wang, Wei-Yin Wu, Gui-Rong Li, Yan Wang, Gang Li. Acacetin attenuates diabetes-induced cardiomyopathy by inhibiting oxidative stress and energy metabolism via PPAR-α/AMPK pathway. European journal of pharmacology. 2022 May; 922(?):174916. doi: 10.1016/j.ejphar.2022.174916. [PMID: 35341782]
Chian-Jiun Liou, Shu-Ju Wu, Szu-Chuan Shen, Li-Chen Chen, Ya-Ling Chen, Wen-Chung Huang. Acacetin Protects against Non-Alcoholic Fatty Liver Disease by Regulating Lipid Accumulation and Inflammation in Mice. International journal of molecular sciences. 2022 Apr; 23(9):. doi: 10.3390/ijms23094687. [PMID: 35563076]
Guangtao Zhang, Zhaoyan Li, Jiahuan Dong, Weili Zhou, Zhanxia Zhang, Zujun Que, Xiaohong Zhu, Yan Xu, Nida Cao, Aiguang Zhao. Acacetin inhibits invasion, migration and TGF-β1-induced EMT of gastric cancer cells through the PI3K/Akt/Snail pathway. BMC complementary medicine and therapies. 2022 Jan; 22(1):10. doi: 10.1186/s12906-021-03494-w. [PMID: 35000605]
Yuan Zhou, Rong Wu, Fei-Fei Cai, Wen-Jun Zhou, Yi-Yu Lu, Hui Zhang, Qi-Long Chen, Ming-Yu Sun, Shi-Bing Su. Development of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis. Pharmaceutical biology. 2021 Dec; 59(1):1594-1606. doi: 10.1080/13880209.2021.1999275. [PMID: 34808067]
Yan Wei, Jianhong Jing, Zhiping Peng, Xiaoqian Liu, Xueyang Wang. Acacetin ameliorates insulin resistance in obesity mice through regulating Treg/Th17 balance via MiR-23b-3p/NEU1 Axis. BMC endocrine disorders. 2021 Mar; 21(1):57. doi: 10.1186/s12902-021-00688-8. [PMID: 33781239]
Jun Gu Kim, Jin Woo Lee, Thi Phuong Linh Le, Jae Sang Han, Yong Beom Cho, Haeun Kwon, Dongho Lee, Mi Kyeong Lee, Bang Yeon Hwang. Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production. Journal of natural products. 2021 03; 84(3):562-569. doi: 10.1021/acs.jnatprod.0c01121. [PMID: 33667099]
Akida Alishir, Jae Sik Yu, Minji Park, Jin-Chul Kim, Changhyun Pang, Jung Kyu Kim, Tae Su Jang, Won Hee Jung, Ki Hyun Kim. Ulmusakidian, a new coumarin glycoside and antifungal phenolic compounds from the root bark of Ulmus davidiana var. japonica. Bioorganic & medicinal chemistry letters. 2021 03; 36(?):127828. doi: 10.1016/j.bmcl.2021.127828. [PMID: 33508466]
Shih-Chung Yen, Liang-Chieh Chen, Han-Li Huang, Sin-Ting Ngo, Yi-Wen Wu, Tony Eight Lin, Tzu-Ying Sung, Ssu-Ting Lien, Hui-Ju Tseng, Shiow-Lin Pan, Wei-Jan Huang, Kai-Cheng Hsu. Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia. Journal of natural products. 2021 01; 84(1):1-10. doi: 10.1021/acs.jnatprod.0c00589. [PMID: 33393294]
Yao Wu, Fei Song, Yunda Li, Jingzhou Li, Yukai Cui, Yixiang Hong, Weimin Han, Weiyin Wu, Ishan Lakhani, Gang Li, Yan Wang. Acacetin exerts antioxidant potential against atherosclerosis through Nrf2 pathway in apoE-/- Mice. Journal of cellular and molecular medicine. 2021 01; 25(1):521-534. doi: 10.1111/jcmm.16106. [PMID: 33241629]
Jingyun Jin, Bin Chen, Xiangyang Zhan, Zhiyi Zhou, Hui Liu, Yun Dong. Network pharmacology and molecular docking study on the mechanism of colorectal cancer treatment using Xiao-Chai-Hu-Tang. PloS one. 2021; 16(6):e0252508. doi: 10.1371/journal.pone.0252508. [PMID: 34125845]
Xuan Guo, Yin Xu, Hua-Liang Tan, Xiao-Juan Wang, Lin Xiao. The Key Ingredient Acacetin in Weishu Decoction Alleviates Gastrointestinal Motility Disorder Based on Network Pharmacology Analysis. Mediators of inflammation. 2021; 2021(?):5265444. doi: 10.1155/2021/5265444. [PMID: 34594156]
Soo-Il Kim, Yun-Ho Kim, Beom Goo Kang, Min-Kyung Kang, Eun-Jung Lee, Dong Yeon Kim, Hyeongjoo Oh, Su Yeon Oh, Woojin Na, Soon Sung Lim, Young-Hee Kang. Linarin and its aglycone acacetin abrogate actin ring formation and focal contact to bone matrix of bone-resorbing osteoclasts through inhibition of αvβ3 integrin and core-linked CD44. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Dec; 79(?):153351. doi: 10.1016/j.phymed.2020.153351. [PMID: 32987362]
Young Hye Seo, Tuy An Trinh, Seung Mok Ryu, Hyo Seon Kim, Goya Choi, Byeong Cheol Moon, Sang Hee Shim, Dae Sik Jang, Dongho Lee, Ki Sung Kang, Jun Lee. Chemical Constituents from the Aerial Parts of Elsholtzia ciliata and Their Protective Activities on Glutamate-Induced HT22 Cell Death. Journal of natural products. 2020 10; 83(10):3149-3155. doi: 10.1021/acs.jnatprod.0c00756. [PMID: 32991171]
Yunfang Zhou, Yingying Tu, Quan Zhou, Ailian Hua, Peiwu Geng, Feifei Chen, Aixia Han, Jin Liu, Dapeng Dai, Shuanghu Wang, Junlu Wang, Congcong Wen. Evaluation of acacetin inhibition potential against cytochrome P450 in vitro and in vivo. Chemico-biological interactions. 2020 Sep; 329(?):109147. doi: 10.1016/j.cbi.2020.109147. [PMID: 32738202]
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