Apigenin (BioDeep_00000000250)

 

Secondary id: BioDeep_00000269950, BioDeep_00000859294

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4,5,7-Trihydroxyflavone; Pelargidenon 1449;

化学式: C15H10O5 (270.052821)
中文名称: 母菊油, 芹菜素
谱图信息: 最多检出来源 Viridiplantae(plant) 1.11%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(cc2=O)c1ccc(cc1)O)O)O
InChI: InChI=1/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H

描述信息

Apigenin is a trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4, 5 and 7. It induces autophagy in leukaemia cells. It has a role as a metabolite and an antineoplastic agent. It is a conjugate acid of an apigenin-7-olate.
Apigenin is a natural product found in Verbascum lychnitis, Carex fraseriana, and other organisms with data available.
Apigenin is a plant-derived flavonoid that has significant promise as a skin cancer chemopreventive agent. Apigenin inhibits the expression of involucrin (hINV), a marker of keratinocyte differentiation, is increased by differentiating agents via a protein kinase Cdelta (PKCdelta), Ras, MEKK1, MEK3 cascade that increases AP1 factor level and AP1 factor binding to DNA elements in the hINV promoter. Apigenin suppresses the 12-O-tetradeconylphorbol-13-acetate-dependent increase in AP1 factor expression and binding to the hINV promoter and the increase in hINV promoter activity. Apigenin also inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1. The suppression of PKCdelta activity is associated with reduced phosphorylation of PKCdelta-Y311. Activation of hINV promoter activity by the green tea polyphenol, (-)-epigellocathecin-3-gallate, is also inhibited by apigenin, suggesting that the two chemopreventive agents can produce opposing actions in keratinocytes. (A7924). Apigenin, a flavone abundantly found in fruits and vegetables, exhibits antiproliferative, anti-inflammatory, and antimetastatic activities through poorly defined mechanisms. This flavonoid provides selective activity to promote caspase-dependent-apoptosis of leukemia cells and uncover an essential role of PKCdelta during the induction of apoptosis by apigenin. (A7925). Apigenin markedly induces the expression of death receptor 5 (DR5) and synergistically acts with exogenous soluble recombinant human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in malignant tumor cells. On the other hand, apigenin-mediated induction of DR5 expression is not observed in normal human peripheral blood mononuclear cells. Moreover, apigenin does not sensitize normal human peripheral blood mononuclear cells to TRAIL-induced apoptosis. (A7926).
5,7,4-trihydroxy-flavone, one of the FLAVONES.
See also: Chamomile (part of); Cannabis sativa subsp. indica top (part of); Fenugreek seed (part of).
Apigenin is a plant-derived flavonoid that has significant promise as a skin cancer chemopreventive agent. Apigenin inhibits the expression of involucrin (hINV), a marker of keratinocyte differentiation, is increased by differentiating agents via a protein kinase Cdelta (PKCdelta), Ras, MEKK1, and MEK3 cascade that increases AP1 factor level and AP1 factor binding to DNA elements in the hINV promoter. Apigenin suppresses the 12-O-tetradeconylphorbol-13-acetate-dependent increase in AP1 factor expression and binding to the hINV promoter. Apigenin also inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1. The suppression of PKCdelta activity is associated with reduced phosphorylation of PKCdelta-Y311. Activation of hINV promoter activity by the green tea polyphenol, (-)-epigellocathecin-3-gallate, is also inhibited by apigenin, suggesting that the two chemopreventive agents can produce opposing actions in keratinocytes (PMID: 16982614). Apigenin, a flavone abundantly found in fruits and vegetables, exhibits antiproliferative, anti-inflammatory, and antimetastatic activities through poorly defined mechanisms. This flavonoid provides selective activity to promote caspase-dependent-apoptosis of leukemia cells and uncover an essential role of PKCdelta during the induction of apoptosis by apigenin (PMID: 16844095). Apigenin markedly induces the expression of death receptor 5 (DR5) and synergistically acts with exogenous soluble recombinant human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in malignant tumor cells. On the other hand, apigenin-mediated induction of DR5 expression is not observed in normal human peripheral blood mononuclear cells. Moreover, apigenin does not sensitize normal human peripheral blood mononuclear cells to TRAIL-induced apoptosis (PMID: 16648565).
Flavone found in a wide variety of foodstuffs; buckwheat, cabbage, celeriac, celery, lettuce, oregano, parsley, peppermint, perilla, pummelo juice, thyme, sweet potatoes, green tea and wild carrot [DFC]
A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4, 5 and 7. It induces autophagy in leukaemia cells.
CONFIDENCE standard compound; INTERNAL_ID 771; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8558; ORIGINAL_PRECURSOR_SCAN_NO 8556
CONFIDENCE standard compound; INTERNAL_ID 771; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5097; ORIGINAL_PRECURSOR_SCAN_NO 5094
CONFIDENCE standard compound; INTERNAL_ID 771; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5096; ORIGINAL_PRECURSOR_SCAN_NO 5093
CONFIDENCE standard compound; INTERNAL_ID 771; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8561; ORIGINAL_PRECURSOR_SCAN_NO 8559
CONFIDENCE standard compound; INTERNAL_ID 771; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5082; ORIGINAL_PRECURSOR_SCAN_NO 5079
CONFIDENCE standard compound; INTERNAL_ID 771; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5104; ORIGINAL_PRECURSOR_SCAN_NO 5099
CONFIDENCE standard compound; INTERNAL_ID 771; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8572; ORIGINAL_PRECURSOR_SCAN_NO 8570
CONFIDENCE standard compound; INTERNAL_ID 771; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8556; ORIGINAL_PRECURSOR_SCAN_NO 8554
CONFIDENCE standard compound; INTERNAL_ID 771; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5085; ORIGINAL_PRECURSOR_SCAN_NO 5082
CONFIDENCE standard compound; INTERNAL_ID 771; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8554; ORIGINAL_PRECURSOR_SCAN_NO 8550
CONFIDENCE standard compound; INTERNAL_ID 771; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8540; ORIGINAL_PRECURSOR_SCAN_NO 8539
CONFIDENCE standard compound; INTERNAL_ID 771; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5090; ORIGINAL_PRECURSOR_SCAN_NO 5089
Acquisition and generation of the data is financially supported in part by CREST/JST.
[Raw Data] CB002_Apigenin_pos_10eV_CB000005.txt
[Raw Data] CB002_Apigenin_pos_40eV_CB000005.txt
[Raw Data] CB002_Apigenin_pos_20eV_CB000005.txt
[Raw Data] CB002_Apigenin_pos_30eV_CB000005.txt
[Raw Data] CB002_Apigenin_pos_50eV_CB000005.txt
[Raw Data] CB002_Apigenin_neg_40eV_000005.txt
[Raw Data] CB002_Apigenin_neg_20eV_000005.txt
[Raw Data] CB002_Apigenin_neg_10eV_000005.txt
[Raw Data] CB002_Apigenin_neg_50eV_000005.txt
CONFIDENCE standard compound; INTERNAL_ID 151
[Raw Data] CB002_Apigenin_neg_30eV_000005.txt
CONFIDENCE standard compound; ML_ID 26
Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM.
Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM.

同义名列表

89 个代谢物同义名

5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4,5,7-Trihydroxyflavone; Pelargidenon 1449;; Apigenin, United States Pharmacopeia (USP) Reference Standard; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-; 4H-1BENZOPYRAN-4-ONE,5,7-DIHYDROXY-2-(4-HYDROXY-PHENYL)-; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4,5,7-Trihydroxyflavone;Apigenol;C.I. Natural Yellow 1; 4H-1-Benzopyran-4-one,7-dihydroxy-2-(4-hydroxyphenyl)-; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one #; Apigenin, primary pharmaceutical reference standard; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone; 5,7-dihydroxy-2-(4-hydroxyphenyl)-chromen-4-one; 5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one; 5,7-Dihydroxy-2-p-hydroxyphenyl-4-chromenone; Apigenin, >=97\\% (TLC), from parsley, powder; 5-18-04-00574 (Beilstein Handbook Reference); 2-(P-HYDROXYPHENYL)-5,7-DIHYDROXY-CHROMONE; APIGENIN (CONSTITUENT OF CHAMOMILE) [DSC]; 2-(p-Hydroxyphenyl)-5,7-dihydroxychromone; D50A2D8A-6D8B-4708-B21E-2DE9580D033F; Apigenin, >=97\\% (TLC), from citrus; APIGENIN (CONSTITUENT OF CHAMOMILE); Apigenin; 4,5,7-Trihydroxyflavone; 4′,5,7-Trihydroxyflavone; Apigenin, analytical standard; FLAVONE, 4,5,7-TRIHYDROXY-; Apigenin, >=95.0\\% (HPLC); ghl.PD_Mitscher_leg0.1194; 5,7,4’-Trihydroxyflavone; 4,5, 7-Trihydroxyflavone; 4,5,7-trihydroxy-Flavone; 4’,5,7-Trihydroxyflavone; 5,7,4-Trihydroxyflavone; 4,5,7-Trihydroxyflavone; Chamomile oil, german; 4,7-Trihydroxyflavone; C.I. Natural Yellow 1; CI NATURAL YELLOW 1; Prestwick2_000414; APIGENIN [WHO-DD]; Prestwick0_000414; Prestwick3_000414; APIGENIN [USP-RS]; Prestwick1_000414; BiomolKI2_000082; Spectrum2_000428; Spectrum3_001882; Spectrum4_001999; APIGENIN [INCI]; UNII-7V515PI7F6; APIGENIN [HSDB]; Naringenin, 18; Matricaria Oil; DivK1c_000798; BPBio1_000406; Oprea1_622293; MEGxp0_000176; Lopac0_000065; Pelargidenone; APIGENIN [MI]; KBio1_000798; Apigenin, 13; KBio3_002887; Tox21_500065; HSCI1_000221; ACon1_002450; Tox21_201542; NCI60_041830; Tox21_302884; Bio1_000376; IDI1_000798; SMP2_000338; Bio1_001354; Bio1_000865; 7V515PI7F6; Apigenine; Chamomile; Versulin; Apigenol; CHEMBL28; Apigenin; APEGENIN; Spigenin; 3cf9; 4der; 4dgm; 4hkk; 4 5 7-trihydroxyflavone; 4',5,7-Trihydroxyflavone



数据库引用编号

69 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

300 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(299)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

3296 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hazal Eken, Nurcan Bektas Turkmen, Behiye Senel, Rana Arslan. Examination of the effects of vitexin and vitexin-loaded solid lipid nanoparticles on neuropathic pain and possible mechanisms of action. Neuropharmacology. 2024 Aug; 253(?):109961. doi: 10.1016/j.neuropharm.2024.109961. [PMID: 38657947]
  • Ping Li, Ruo-Lin Fang, Wen Wang, Xi-Xi Zeng, Tian Lan, Shi-Yu Liu, Yan-Jun Hu, Qing Shen, Si-Wei Wang, Yu-Hua Tong, Zhu-Jun Mao. Apigenin suppresses epithelial-mesenchymal transition in high glucose-induced retinal pigment epithelial cell by inhibiting CBP/p300-mediated histone acetylation. Biochemical and biophysical research communications. 2024 Jul; 717(?):150061. doi: 10.1016/j.bbrc.2024.150061. [PMID: 38718570]
  • Mohsen Akbari, Salar Moardi, Homeyra Piri, Roonak Amiri, Farzaneh Aliaqabozorg, Elham Sadat Afraz. The identification of active compounds and therapeutic properties of fermented and non-fermented red sorghum for the treatment of Alzheimer's dementia. Experimental gerontology. 2024 Jul; 192(?):112459. doi: 10.1016/j.exger.2024.112459. [PMID: 38740315]
  • Yanqin Luo, Bo Lin, Peng Yu, Di Zhang, Yingfan Hu, Xianli Meng, Li Xiang. Scutellaria baicalensis water decoction ameliorates lower respiratory tract infection by modulating respiratory microbiota. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155706. doi: 10.1016/j.phymed.2024.155706. [PMID: 38723528]
  • Nguyen Thu Hang, Dau Thi Thu Ha, Ngo Hang Nga, Nguyen Van Phuong. Deep eutectic solvent combined with soybean as an efficient approach to enhance the content of apigenin in the Chrysanthemum indicum L. extract. Food chemistry. 2024 Jul; 445(?):138793. doi: 10.1016/j.foodchem.2024.138793. [PMID: 38382256]
  • Gaoxuan Shao, Ying Liu, Lu Lu, Lei Wang, Guang Ji, Hanchen Xu. Therapeutic potential of traditional Chinese medicine in the prevention and treatment of digestive inflammatory cancer transformation: Portulaca oleracea L. as a promising drug. Journal of ethnopharmacology. 2024 Jun; 327(?):117999. doi: 10.1016/j.jep.2024.117999. [PMID: 38447616]
  • L Bonilla-Vidal, M Espina, M L García, L Baldomà, J Badia, J A González, L M Delgado, A Gliszczyńska, E B Souto, E Sánchez-López. Novel nanostructured lipid carriers loading Apigenin for anterior segment ocular pathologies. International journal of pharmaceutics. 2024 Jun; 658(?):124222. doi: 10.1016/j.ijpharm.2024.124222. [PMID: 38735632]
  • Hui Ma, Grace Gar-Lee Yue, Julia Kin-Ming Lee, Si Gao, Ka-Ki Yuen, Wen Cheng, Xiang Li, Clara Bik-San Lau. Scutellarin, a flavonoid compound from Scutellaria barbata, suppresses growth of breast cancer stem cells in vitro and in tumor-bearing mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155418. doi: 10.1016/j.phymed.2024.155418. [PMID: 38518647]
  • Obed Jackson Amoah, Samir Bahadur Thapa, Su Yeong Ma, Hue Thi Nguyen, Morshed Md Zakaria, Jae Kyung Sohng. Biosynthesis of Apigenin Glucosides in Engineered Corynebacterium glutamicum. Journal of microbiology and biotechnology. 2024 May; 34(5):1154-1163. doi: 10.4014/jmb.2401.01017. [PMID: 38563097]
  • Xiao-Yu Zhang, Kai-Rou Xia, Ya-Ni Wang, Pei Liu, Er-Xin Shang, Cong-Yan Liu, Yu-Ping Liu, Ding Qu, Wei-Wen Li, Jin-Ao Duan, Yan Chen, Huang-Qin Zhang. Unraveling the pharmacodynamic substances and possible mechanism of Trichosanthis Pericarpium in the treatment of coronary heart disease based on plasma pharmacochemistry, network pharmacology and experimental validation. Journal of ethnopharmacology. 2024 May; 325(?):117869. doi: 10.1016/j.jep.2024.117869. [PMID: 38342153]
  • Hui Yu, Zhongfu Xing, Kaijie Jia, Sai Li, Yankun Xu, Pan Zhao, Xiaojing Zhu. Inquiry lipaseoring the mechanism of pancreatic lipase inhibition by isovitexin based on multispectral method and enzyme inhibition assay. Luminescence : the journal of biological and chemical luminescence. 2024 May; 39(5):e4765. doi: 10.1002/bio.4765. [PMID: 38769927]
  • Anna Balykina, Lidia Naida, Kürsat Kirkgöz, Viacheslav O Nikolaev, Ekaterina Fock, Michael Belyakov, Anastasiia Whaley, Andrei Whaley, Valentina Shpakova, Natalia Rukoyatkina, Stepan Gambaryan. Antiplatelet Effects of Flavonoid Aglycones Are Mediated by Activation of Cyclic Nucleotide-Dependent Protein Kinases. International journal of molecular sciences. 2024 Apr; 25(9):. doi: 10.3390/ijms25094864. [PMID: 38732081]
  • Zhao Cui, Caifeng Li, Wei Liu, Mo Sun, Shiwen Deng, Junxian Cao, Hongjun Yang, Peng Chen. Scutellarin activates IDH1 to exert antitumor effects in hepatocellular carcinoma progression. Cell death & disease. 2024 Apr; 15(4):267. doi: 10.1038/s41419-024-06625-6. [PMID: 38622131]
  • Ling Ling Lv, Li Yun Li, Long Qian Xiao, Jian Hui Pi. Transcriptomic and targeted metabolomic analyses provide insights into the flavonoids biosynthesis in the flowers of Lonicera macranthoides. BMC biotechnology. 2024 Apr; 24(1):19. doi: 10.1186/s12896-024-00846-5. [PMID: 38609923]
  • Wen-Cong Gao, Tie-Hua Yang, Bin-Bao Wang, Qian Liu, Qing Li, Xiao-Huan Zhou, Chang-Bo Zheng, Peng Chen. Scutellarin inhibits oleic acid induced vascular smooth muscle foam cell formation via activating autophagy and inhibiting NLRP3 inflammasome activation. Clinical and experimental pharmacology & physiology. 2024 04; 51(4):e13845. doi: 10.1111/1440-1681.13845. [PMID: 38382550]
  • Jaroslaw Czubinski, Krzysztof Dwiecki. Effect of different oligomerization assemblies of γ-conglutin on its interaction behavior with vitexin. Journal of the science of food and agriculture. 2024 Apr; 104(6):3381-3391. doi: 10.1002/jsfa.13223. [PMID: 38100295]
  • Xin Huang, Xiaopei Hu, Suhong Li, Tuoping Li. Vitexin-rhamnoside encapsulated with zein-pectin nanoparticles relieved high-fat diet induced lipid metabolism disorders in mice by altering the gut microbiota. International journal of biological macromolecules. 2024 Apr; 264(Pt 2):130704. doi: 10.1016/j.ijbiomac.2024.130704. [PMID: 38460630]
  • Noha Mokhtar Abd-El-Aziz, Mohamed Saeed Hifnawy, Rehab Ahmed Lotfy, Inas Youssef Younis. LC/MS/MS and GC/MS/MS metabolic profiling of Leontodon hispidulus, in vitro and in silico anticancer activity evaluation targeting hexokinase 2 enzyme. Scientific reports. 2024 03; 14(1):6872. doi: 10.1038/s41598-024-57288-4. [PMID: 38519553]
  • Wonseok Kim, Sebastián Acosta-Jurado, Sunhyung Kim, Hari B Krishnan. Calcium Induces the Cleavage of NopA and Regulates the Expression of Nodulation Genes and Secretion of T3SS Effectors in Sinorhizobium fredii NGR234. International journal of molecular sciences. 2024 Mar; 25(6):. doi: 10.3390/ijms25063443. [PMID: 38542415]
  • Zhenhua Dang, Ying Xu, Xin Zhang, Wentao Mi, Yuan Chi, Yunyun Tian, Yaling Liu, Weibo Ren. Chromosome-level genome assembly provides insights into the genome evolution and functional importance of the phenylpropanoid-flavonoid pathway in Thymus mongolicus. BMC genomics. 2024 Mar; 25(1):291. doi: 10.1186/s12864-024-10202-8. [PMID: 38504151]
  • Sara Gamal Sherif, Marwa Tarek, Yasmine Gamal Sabry, Azza Hassan Abou Ghalia. Effect of apigenin on dynamin-related protein 1 in type 1 diabetic rats with cardiovascular complications. Gene. 2024 Mar; 898(?):148107. doi: 10.1016/j.gene.2023.148107. [PMID: 38141690]
  • Cem Baltacıoğlu, Hande Baltacıoğlu, İlhami Okur, Mehmet Yetişen, Hami Alpas. Recovery of phenolic compounds from peach pomace using conventional solvent extraction and different emerging techniques. Journal of food science. 2024 Mar; 89(3):1672-1683. doi: 10.1111/1750-3841.16972. [PMID: 38343298]
  • Rui Li, Dingtao Wu, Jianping Hu, Yuqi Ma, Yabo Ba, Liang Zou, Yichen Hu. Polyphenol-enriched Penthorum chinense Pursh ameliorates alcohol-related liver injury through Ras/Raf/MEK/ERK pathway: Integrating network pharmacology and experiment validation. Journal of ethnopharmacology. 2024 Mar; 321(?):117513. doi: 10.1016/j.jep.2023.117513. [PMID: 38040131]
  • Guangjun Yu, Yichun Shi, Shiqin Cong, Chengxun Wu, Jing Liu, Yanghui Zhang, Hongyan Liu, Xiuxiu Liu, Haixing Deng, Zhenghuai Tan, Yong Deng. Synthesis and evaluation of butylphthalide-scutellarein hybrids as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2024 Feb; 265(?):116099. doi: 10.1016/j.ejmech.2023.116099. [PMID: 38160618]
  • Alyssa N Cavalier, Zachary S Clayton, Devin Wahl, David A Hutton, Cali M McEntee, Douglas R Seals, Thomas J LaRocca. Protective effects of apigenin on the brain transcriptome with aging. Mechanisms of ageing and development. 2024 Feb; 217(?):111889. doi: 10.1016/j.mad.2023.111889. [PMID: 38007051]
  • Keyi Fu, Christopher L Schardl, Daniel Cook, Xuanli Cao, Ning Ling, Chunyu He, Dandan Wu, Longhai Xue, Yanzhong Li, Zunji Shi. Multiomics Reveals Mechanisms of Alternaria oxytropis Inhibiting Pathogenic Fungi in Oxytropis ochrocephala. Journal of agricultural and food chemistry. 2024 Jan; 72(4):2397-2409. doi: 10.1021/acs.jafc.3c09049. [PMID: 38230662]
  • Ming-Hsien Chien, Yi-Chieh Yang, Kuo-Hao Ho, Yi-Fang Ding, Li-Hsin Chen, Wen-Kuan Chiu, Ji-Qing Chen, Min-Che Tung, Michael Hsiao, Wei-Jiunn Lee. Cyclic increase in the ADAMTS1-L1CAM-EGFR axis promotes the EMT and cervical lymph node metastasis of oral squamous cell carcinoma. Cell death & disease. 2024 01; 15(1):82. doi: 10.1038/s41419-024-06452-9. [PMID: 38263290]
  • Ida K L Andersen, Inge S Fomsgaard, Jim Rasmussen. Intercropping of Narrow-Leafed Lupin (Lupinus angustifolius L.) and Barley (Hordeum vulgare L.) Affects the Flavonoid Composition of Both Crops. Journal of agricultural and food chemistry. 2024 Jan; 72(1):108-115. doi: 10.1021/acs.jafc.3c03684. [PMID: 38146912]
  • Michalis K Stefanakis, Olga St Tsiftsoglou, Pavle Z Mašković, Diamanto Lazari, Haralambos E Katerinopoulos. Chemical Constituents and Anticancer Activities of the Extracts from Phlomis × commixta Rech. f. (P. cretica × P. lanata). International journal of molecular sciences. 2024 Jan; 25(2):. doi: 10.3390/ijms25020816. [PMID: 38255889]
  • Manoharan Harini, Kuppuswamy Kavitha, Vadivel Prabakaran, Anandan Krithika, Shanmugam Dinesh, Arumugam Rajalakshmi, Gopal Suresh, Rengarajulu Puvanakrishnan, Balasubramanian Ramesh. Identification of apigenin-4'-glucoside as bacterial DNA gyrase inhibitor by QSAR modeling, molecular docking, DFT, molecular dynamics, and in vitro confirmation studies. Journal of molecular modeling. 2024 Jan; 30(1):22. doi: 10.1007/s00894-023-05813-z. [PMID: 38170229]
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