Versulin (BioDeep_00000859294)

Main id: BioDeep_00000269950

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)- (9CI)

化学式: C15H10O5 (270.0528)
中文名称: 芹菜素, 母菊油
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O
InChI: InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H

描述信息

Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM.
Apigenin (4',5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a Ki of 2 μM.

同义名列表

92 个代谢物同义名

4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)- (9CI); 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone; 5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one; 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-chromenone; 5-18-04-00574 (Beilstein Handbook Reference); 5,7-dihydroxy-2-(4-hydroxyphenyl)chromone; 2-(p-Hydroxyphenyl)-5,7-dihydroxychromone; Biochem Biophys Res Comm 212: 767 (1997); Apigenin; 4,5,7-Trihydroxyflavone; FLAVONE, 4,5,7-TRIHYDROXY-; ghl.PD_Mitscher_leg0.1194; 4′,5,7-Trihydroxyflavone; 5,7,4-Trihydroxyflavone; 4,5,7-Trihydroxyflavone; C.I. Natural Yellow 1; SDCCGMLS-0066379.P001; nchembio790-comp26; Prestwick2_000414; Pelargidenon 1449; Prestwick0_000414; Prestwick3_000414; Prestwick1_000414; EINECS 208-292-3; BiomolKI2_000082; Spectrum2_000428; Spectrum3_001882; Spectrum4_001999; NCGC00025057-05; NCGC00025057-09; BiomolKI_000078; NCGC00025057-04; NCGC00025057-08; NCGC00015049-02; NCGC00025057-02; NCGC00025057-01; NCGC00015049-01; SPECTRUM200846; Matricaria Oil; KBioGR_002565; DivK1c_000798; BPBio1_000406; BSPBio_003384; Oprea1_622293; MEGxp0_000176; BSPBio_000368; Prestwick_719; Lopac0_000065; KBio1_000798; KBio3_002887; HSCI1_000221; ACon1_002450; ZINC00004495; SPBio_002307; Lopac-A-3145; NINDS_000798; SPBio_000416; CAS-520-36-5; NCI60_041830; A3145_SIGMA; Tocris-1227; Bio1_000376; IDI1_000798; SMP2_000338; AIDS-001401; 461015-54-3; BRN 0262620; Bio1_001354; 10798_FLUKA; CHEBI:18388; Bio1_000865; EU-0100065; CCRIS 3789; AIDS001401; Apigenine; NSC 83244; Chamomile; Versulin; UCCF 031; Apigenol; NSC83244; 520-36-5; Apigenin; ST056301; Spigenin; ND-9076; K00045; C01477; 4',5,7-Trihydroxyflavone; Apigenin



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

914 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ABCB1, CASP8, CDK1, ESR1, MAPK1, NFKB1, NOS3, PTGS2, TP53, XDH
Peripheral membrane protein 2 ESR1, PTGS2
Endoplasmic reticulum membrane 2 CDK1, PTGS2
Nucleus 7 CASP8, CDK1, ESR1, MAPK1, NFKB1, NOS3, TP53
cytosol 11 CASP8, CDK1, ESR1, GPT, MAPK1, NFKB1, NOS3, PRKCQ, SLC2A1, TP53, XDH
centrosome 3 CDK1, MAPK1, TP53
nucleoplasm 7 CASP8, CDK1, ESR1, MAPK1, NFKB1, NOS3, TP53
Cell membrane 3 ABCB1, ESR1, SLC2A1
Cytoplasmic side 1 ESR1
lamellipodium 1 CASP8
Multi-pass membrane protein 2 ABCB1, SLC2A1
Synapse 1 MAPK1
cell surface 2 ABCB1, ICAM1
Golgi apparatus 3 ESR1, MAPK1, NOS3
Golgi membrane 2 NOS3, SLC2A1
lysosomal membrane 1 GAA
sarcolemma 1 SLC2A1
Lysosome 1 GAA
Presynapse 1 SLC2A1
plasma membrane 9 ABCB1, ESR1, GAA, ICAM1, IFNLR1, MAPK1, NOS3, PRKCQ, SLC2A1
Membrane 8 ABCB1, CDK1, ESR1, GAA, ICAM1, IFNLR1, SLC2A1, TP53
apical plasma membrane 2 ABCB1, SLC2A1
basolateral plasma membrane 1 SLC2A1
caveola 4 MAPK1, NOS3, PTGS2, SLC2A1
extracellular exosome 6 ABCB1, CDK1, GAA, GPT, ICAM1, SLC2A1
Lysosome membrane 1 GAA
endoplasmic reticulum 2 PTGS2, TP53
extracellular space 6 CCL2, CXCL8, ICAM1, IL17A, IL4, XDH
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 NOS3
intercalated disc 1 SLC2A1
mitochondrion 5 CASP8, CDK1, MAPK1, NFKB1, TP53
protein-containing complex 4 CASP8, ESR1, PTGS2, TP53
intracellular membrane-bounded organelle 1 GAA
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 2 ICAM1, IFNLR1
Secreted 5 CCL2, CXCL8, GAA, IL17A, IL4
extracellular region 7 CCL2, CXCL8, GAA, IL17A, IL4, MAPK1, NFKB1
mitochondrial outer membrane 1 CASP8
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CDK1, TP53
transcription regulator complex 3 ESR1, NFKB1, TP53
centriolar satellite 1 PRKCQ
photoreceptor inner segment 1 SLC2A1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 3 CDK1, MAPK1, TP53
external side of plasma membrane 2 ICAM1, IL17A
Z disc 1 SLC2A1
nucleolus 1 TP53
midbody 2 CDK1, SLC2A1
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Early endosome 1 MAPK1
Apical cell membrane 1 ABCB1
Cell projection, lamellipodium 1 CASP8
Membrane raft 1 ICAM1
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton 1 TP53
Cytoplasm, cytoskeleton, spindle 1 MAPK1
focal adhesion 2 ICAM1, MAPK1
spindle 1 MAPK1
Peroxisome 1 XDH
sarcoplasmic reticulum 1 XDH
Nucleus, PML body 1 TP53
PML body 1 TP53
collagen-containing extracellular matrix 1 ICAM1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 MAPK1
neuron projection 1 PTGS2
chromatin 3 ESR1, NFKB1, TP53
mitotic spindle 2 CDK1, MAPK1
cytoskeleton 3 CASP8, MAPK1, NOS3
chromosome, telomeric region 1 CDK1
blood microparticle 1 SLC2A1
site of double-strand break 1 TP53
Membrane, caveola 1 MAPK1
female germ cell nucleus 1 SLC2A1
tertiary granule membrane 1 GAA
Melanosome 1 SLC2A1
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
euchromatin 1 ESR1
cell body 1 CASP8
germ cell nucleus 1 TP53
replication fork 1 TP53
pseudopodium 1 MAPK1
ficolin-1-rich granule lumen 1 MAPK1
secretory granule lumen 1 NFKB1
endoplasmic reticulum lumen 2 MAPK1, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
cortical actin cytoskeleton 1 SLC2A1
specific granule lumen 1 NFKB1
endocytic vesicle membrane 1 NOS3
azurophil granule membrane 1 GAA
azurophil granule lumen 1 MAPK1
immunological synapse 2 ICAM1, PRKCQ
aggresome 1 PRKCQ
[Isoform 1]: Nucleus 2 ESR1, TP53
ficolin-1-rich granule membrane 1 GAA
spindle microtubule 1 CDK1
external side of apical plasma membrane 1 ABCB1
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 1 CASP8
ripoptosome 1 CASP8
female pronucleus 1 SLC2A1
cyclin-dependent protein kinase holoenzyme complex 1 CDK1
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 1 CDK1
autolysosome lumen 1 GAA
glucose transporter complex 1 SLC2A1
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Hazal Eken, Nurcan Bektas Turkmen, Behiye Senel, Rana Arslan. Examination of the effects of vitexin and vitexin-loaded solid lipid nanoparticles on neuropathic pain and possible mechanisms of action. Neuropharmacology. 2024 Aug; 253(?):109961. doi: 10.1016/j.neuropharm.2024.109961. [PMID: 38657947]
  • Ping Li, Ruo-Lin Fang, Wen Wang, Xi-Xi Zeng, Tian Lan, Shi-Yu Liu, Yan-Jun Hu, Qing Shen, Si-Wei Wang, Yu-Hua Tong, Zhu-Jun Mao. Apigenin suppresses epithelial-mesenchymal transition in high glucose-induced retinal pigment epithelial cell by inhibiting CBP/p300-mediated histone acetylation. Biochemical and biophysical research communications. 2024 Jul; 717(?):150061. doi: 10.1016/j.bbrc.2024.150061. [PMID: 38718570]
  • Yanqin Luo, Bo Lin, Peng Yu, Di Zhang, Yingfan Hu, Xianli Meng, Li Xiang. Scutellaria baicalensis water decoction ameliorates lower respiratory tract infection by modulating respiratory microbiota. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155706. doi: 10.1016/j.phymed.2024.155706. [PMID: 38723528]
  • Mohsen Akbari, Salar Moardi, Homeyra Piri, Roonak Amiri, Farzaneh Aliaqabozorg, Elham Sadat Afraz. The identification of active compounds and therapeutic properties of fermented and non-fermented red sorghum for the treatment of Alzheimer's dementia. Experimental gerontology. 2024 Jul; 192(?):112459. doi: 10.1016/j.exger.2024.112459. [PMID: 38740315]
  • Nguyen Thu Hang, Dau Thi Thu Ha, Ngo Hang Nga, Nguyen Van Phuong. Deep eutectic solvent combined with soybean as an efficient approach to enhance the content of apigenin in the Chrysanthemum indicum L. extract. Food chemistry. 2024 Jul; 445(?):138793. doi: 10.1016/j.foodchem.2024.138793. [PMID: 38382256]
  • Gaoxuan Shao, Ying Liu, Lu Lu, Lei Wang, Guang Ji, Hanchen Xu. Therapeutic potential of traditional Chinese medicine in the prevention and treatment of digestive inflammatory cancer transformation: Portulaca oleracea L. as a promising drug. Journal of ethnopharmacology. 2024 Jun; 327(?):117999. doi: 10.1016/j.jep.2024.117999. [PMID: 38447616]
  • L Bonilla-Vidal, M Espina, M L García, L Baldomà, J Badia, J A González, L M Delgado, A Gliszczyńska, E B Souto, E Sánchez-López. Novel nanostructured lipid carriers loading Apigenin for anterior segment ocular pathologies. International journal of pharmaceutics. 2024 Jun; 658(?):124222. doi: 10.1016/j.ijpharm.2024.124222. [PMID: 38735632]
  • Hui Ma, Grace Gar-Lee Yue, Julia Kin-Ming Lee, Si Gao, Ka-Ki Yuen, Wen Cheng, Xiang Li, Clara Bik-San Lau. Scutellarin, a flavonoid compound from Scutellaria barbata, suppresses growth of breast cancer stem cells in vitro and in tumor-bearing mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155418. doi: 10.1016/j.phymed.2024.155418. [PMID: 38518647]
  • Obed Jackson Amoah, Samir Bahadur Thapa, Su Yeong Ma, Hue Thi Nguyen, Morshed Md Zakaria, Jae Kyung Sohng. Biosynthesis of Apigenin Glucosides in Engineered Corynebacterium glutamicum. Journal of microbiology and biotechnology. 2024 May; 34(5):1154-1163. doi: 10.4014/jmb.2401.01017. [PMID: 38563097]
  • Xiao-Yu Zhang, Kai-Rou Xia, Ya-Ni Wang, Pei Liu, Er-Xin Shang, Cong-Yan Liu, Yu-Ping Liu, Ding Qu, Wei-Wen Li, Jin-Ao Duan, Yan Chen, Huang-Qin Zhang. Unraveling the pharmacodynamic substances and possible mechanism of Trichosanthis Pericarpium in the treatment of coronary heart disease based on plasma pharmacochemistry, network pharmacology and experimental validation. Journal of ethnopharmacology. 2024 May; 325(?):117869. doi: 10.1016/j.jep.2024.117869. [PMID: 38342153]
  • Hui Yu, Zhongfu Xing, Kaijie Jia, Sai Li, Yankun Xu, Pan Zhao, Xiaojing Zhu. Inquiry lipaseoring the mechanism of pancreatic lipase inhibition by isovitexin based on multispectral method and enzyme inhibition assay. Luminescence : the journal of biological and chemical luminescence. 2024 May; 39(5):e4765. doi: 10.1002/bio.4765. [PMID: 38769927]
  • Anna Balykina, Lidia Naida, Kürsat Kirkgöz, Viacheslav O Nikolaev, Ekaterina Fock, Michael Belyakov, Anastasiia Whaley, Andrei Whaley, Valentina Shpakova, Natalia Rukoyatkina, Stepan Gambaryan. Antiplatelet Effects of Flavonoid Aglycones Are Mediated by Activation of Cyclic Nucleotide-Dependent Protein Kinases. International journal of molecular sciences. 2024 Apr; 25(9):. doi: 10.3390/ijms25094864. [PMID: 38732081]
  • Zhao Cui, Caifeng Li, Wei Liu, Mo Sun, Shiwen Deng, Junxian Cao, Hongjun Yang, Peng Chen. Scutellarin activates IDH1 to exert antitumor effects in hepatocellular carcinoma progression. Cell death & disease. 2024 Apr; 15(4):267. doi: 10.1038/s41419-024-06625-6. [PMID: 38622131]
  • Ling Ling Lv, Li Yun Li, Long Qian Xiao, Jian Hui Pi. Transcriptomic and targeted metabolomic analyses provide insights into the flavonoids biosynthesis in the flowers of Lonicera macranthoides. BMC biotechnology. 2024 Apr; 24(1):19. doi: 10.1186/s12896-024-00846-5. [PMID: 38609923]
  • Xin Huang, Xiaopei Hu, Suhong Li, Tuoping Li. Vitexin-rhamnoside encapsulated with zein-pectin nanoparticles relieved high-fat diet induced lipid metabolism disorders in mice by altering the gut microbiota. International journal of biological macromolecules. 2024 Apr; 264(Pt 2):130704. doi: 10.1016/j.ijbiomac.2024.130704. [PMID: 38460630]
  • Jaroslaw Czubinski, Krzysztof Dwiecki. Effect of different oligomerization assemblies of γ-conglutin on its interaction behavior with vitexin. Journal of the science of food and agriculture. 2024 Apr; 104(6):3381-3391. doi: 10.1002/jsfa.13223. [PMID: 38100295]
  • Wen-Cong Gao, Tie-Hua Yang, Bin-Bao Wang, Qian Liu, Qing Li, Xiao-Huan Zhou, Chang-Bo Zheng, Peng Chen. Scutellarin inhibits oleic acid induced vascular smooth muscle foam cell formation via activating autophagy and inhibiting NLRP3 inflammasome activation. Clinical and experimental pharmacology & physiology. 2024 04; 51(4):e13845. doi: 10.1111/1440-1681.13845. [PMID: 38382550]
  • Noha Mokhtar Abd-El-Aziz, Mohamed Saeed Hifnawy, Rehab Ahmed Lotfy, Inas Youssef Younis. LC/MS/MS and GC/MS/MS metabolic profiling of Leontodon hispidulus, in vitro and in silico anticancer activity evaluation targeting hexokinase 2 enzyme. Scientific reports. 2024 03; 14(1):6872. doi: 10.1038/s41598-024-57288-4. [PMID: 38519553]
  • Zhenhua Dang, Ying Xu, Xin Zhang, Wentao Mi, Yuan Chi, Yunyun Tian, Yaling Liu, Weibo Ren. Chromosome-level genome assembly provides insights into the genome evolution and functional importance of the phenylpropanoid-flavonoid pathway in Thymus mongolicus. BMC genomics. 2024 Mar; 25(1):291. doi: 10.1186/s12864-024-10202-8. [PMID: 38504151]
  • Wonseok Kim, Sebastián Acosta-Jurado, Sunhyung Kim, Hari B Krishnan. Calcium Induces the Cleavage of NopA and Regulates the Expression of Nodulation Genes and Secretion of T3SS Effectors in Sinorhizobium fredii NGR234. International journal of molecular sciences. 2024 Mar; 25(6):. doi: 10.3390/ijms25063443. [PMID: 38542415]
  • Sara Gamal Sherif, Marwa Tarek, Yasmine Gamal Sabry, Azza Hassan Abou Ghalia. Effect of apigenin on dynamin-related protein 1 in type 1 diabetic rats with cardiovascular complications. Gene. 2024 Mar; 898(?):148107. doi: 10.1016/j.gene.2023.148107. [PMID: 38141690]
  • Rui Li, Dingtao Wu, Jianping Hu, Yuqi Ma, Yabo Ba, Liang Zou, Yichen Hu. Polyphenol-enriched Penthorum chinense Pursh ameliorates alcohol-related liver injury through Ras/Raf/MEK/ERK pathway: Integrating network pharmacology and experiment validation. Journal of ethnopharmacology. 2024 Mar; 321(?):117513. doi: 10.1016/j.jep.2023.117513. [PMID: 38040131]
  • Cem Baltacıoğlu, Hande Baltacıoğlu, İlhami Okur, Mehmet Yetişen, Hami Alpas. Recovery of phenolic compounds from peach pomace using conventional solvent extraction and different emerging techniques. Journal of food science. 2024 Mar; 89(3):1672-1683. doi: 10.1111/1750-3841.16972. [PMID: 38343298]
  • Guangjun Yu, Yichun Shi, Shiqin Cong, Chengxun Wu, Jing Liu, Yanghui Zhang, Hongyan Liu, Xiuxiu Liu, Haixing Deng, Zhenghuai Tan, Yong Deng. Synthesis and evaluation of butylphthalide-scutellarein hybrids as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2024 Feb; 265(?):116099. doi: 10.1016/j.ejmech.2023.116099. [PMID: 38160618]
  • Alyssa N Cavalier, Zachary S Clayton, Devin Wahl, David A Hutton, Cali M McEntee, Douglas R Seals, Thomas J LaRocca. Protective effects of apigenin on the brain transcriptome with aging. Mechanisms of ageing and development. 2024 Feb; 217(?):111889. doi: 10.1016/j.mad.2023.111889. [PMID: 38007051]
  • Keyi Fu, Christopher L Schardl, Daniel Cook, Xuanli Cao, Ning Ling, Chunyu He, Dandan Wu, Longhai Xue, Yanzhong Li, Zunji Shi. Multiomics Reveals Mechanisms of Alternaria oxytropis Inhibiting Pathogenic Fungi in Oxytropis ochrocephala. Journal of agricultural and food chemistry. 2024 Jan; 72(4):2397-2409. doi: 10.1021/acs.jafc.3c09049. [PMID: 38230662]
  • Ming-Hsien Chien, Yi-Chieh Yang, Kuo-Hao Ho, Yi-Fang Ding, Li-Hsin Chen, Wen-Kuan Chiu, Ji-Qing Chen, Min-Che Tung, Michael Hsiao, Wei-Jiunn Lee. Cyclic increase in the ADAMTS1-L1CAM-EGFR axis promotes the EMT and cervical lymph node metastasis of oral squamous cell carcinoma. Cell death & disease. 2024 01; 15(1):82. doi: 10.1038/s41419-024-06452-9. [PMID: 38263290]
  • Ida K L Andersen, Inge S Fomsgaard, Jim Rasmussen. Intercropping of Narrow-Leafed Lupin (Lupinus angustifolius L.) and Barley (Hordeum vulgare L.) Affects the Flavonoid Composition of Both Crops. Journal of agricultural and food chemistry. 2024 Jan; 72(1):108-115. doi: 10.1021/acs.jafc.3c03684. [PMID: 38146912]
  • Michalis K Stefanakis, Olga St Tsiftsoglou, Pavle Z Mašković, Diamanto Lazari, Haralambos E Katerinopoulos. Chemical Constituents and Anticancer Activities of the Extracts from Phlomis × commixta Rech. f. (P. cretica × P. lanata). International journal of molecular sciences. 2024 Jan; 25(2):. doi: 10.3390/ijms25020816. [PMID: 38255889]
  • Manoharan Harini, Kuppuswamy Kavitha, Vadivel Prabakaran, Anandan Krithika, Shanmugam Dinesh, Arumugam Rajalakshmi, Gopal Suresh, Rengarajulu Puvanakrishnan, Balasubramanian Ramesh. Identification of apigenin-4'-glucoside as bacterial DNA gyrase inhibitor by QSAR modeling, molecular docking, DFT, molecular dynamics, and in vitro confirmation studies. Journal of molecular modeling. 2024 Jan; 30(1):22. doi: 10.1007/s00894-023-05813-z. [PMID: 38170229]
  • Xuerong Zhao, Zhuoya Wang, Guanlin Wu, Lianhong Yin, Lina Xu, Ning Wang, Jinyong Peng. Apigenin-7-glucoside-loaded nanoparticle alleviates intestinal ischemia-reperfusion by ATF3/SLC7A11-mediated ferroptosis. Journal of controlled release : official journal of the Controlled Release Society. 2024 Jan; 366(?):182-193. doi: 10.1016/j.jconrel.2023.12.038. [PMID: 38145659]
  • Dalia Ali, Meshail Okla, Sarah Abuelreich, Radhakrishnan Vishnubalaji, Nicholas Ditzel, Rimi Hamam, Justyna M Kowal, Ahmed Sayed, Abdullah Aldahmash, Nehad M Alajez, Moustapha Kassem. Apigenin and Rutaecarpine reduce the burden of cellular senescence in bone marrow stromal stem cells. Frontiers in endocrinology. 2024; 15(?):1360054. doi: 10.3389/fendo.2024.1360054. [PMID: 38638133]
  • Wei Zhang, Peng Zhang, Le-Hua Xu, Kai Gao, Juan-Li Zhang, Min-Na Yao, Rui-Li Li, Chao Guo, Jing-Wen Wang, Quan-Xiang Wu. Ethanol extract of Verbena officinalis alleviates MCAO-induced ischaemic stroke by inhibiting IL17A pathway-regulated neuroinflammation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155237. doi: 10.1016/j.phymed.2023.155237. [PMID: 38056148]
  • Taghreed A Majrashi, Mahmoud A El Hassab, Sara H Mahmoud, Ahmed Mostafa, Engy A Wahsh, Eslam B Elkaeed, Fatma E Hassan, Wagdy M Eldehna, Shimaa M Abdelgawad. In vitro biological evaluation and in silico insights into the antiviral activity of standardized olive leaves extract against SARS-CoV-2. PloS one. 2024; 19(4):e0301086. doi: 10.1371/journal.pone.0301086. [PMID: 38662719]
  • Laura Fossatelli, Zaira Maroccia, Carla Fiorentini, Massimo Bonucci. Resources for Human Health from the Plant Kingdom: The Potential Role of the Flavonoid Apigenin in Cancer Counteraction. International journal of molecular sciences. 2023 Dec; 25(1):. doi: 10.3390/ijms25010251. [PMID: 38203418]
  • Mareia Ahmed-M Elgaleidh, Hafize Dilek Tepe, Fatma Doyuk, Talip Çeter, İdris Yazgan. Identification of Marker Molecules in Aqueous Plant Extracts Affecting the Gold Nanostructures' Morphology and Size. Chemistry & biodiversity. 2023 Dec; ?(?):e202301349. doi: 10.1002/cbdv.202301349. [PMID: 38108659]
  • Dominika Szadkowska, Magdalena Chłopecka, Jakub W Strawa, Katarzyna Jakimiuk, Daniel Augustynowicz, Michał Tomczyk, Marta Mendel. Effects of Cirsium palustre Extracts and Their Main Flavonoids on Colon Motility-An Ex Vivo Study. International journal of molecular sciences. 2023 Dec; 24(24):. doi: 10.3390/ijms242417283. [PMID: 38139112]
  • Mehmet Salih Bakaç, Abdulahad Dogan, Mustafa Abdullah Yılmaz, Fikret Altındag, Fatih Donmez, Abdulhamit Battal. Ameliorative effects of Scutellaria Pinnatifida subsp. pichleri (Stapf) Rech.f. Extract in streptozotocin-induced diabetic rats: chemical composition, biochemical and histopathological evaluation. BMC complementary medicine and therapies. 2023 Nov; 23(1):410. doi: 10.1186/s12906-023-04252-w. [PMID: 37964249]
  • A I Savko, T V Ilyich, A G Veiko, T A Kovalenia, E A Lapshina, I B Zavodnik. The flavonoids fisetin, apigenin, kaempferol, naringenin, naringin regulate respiratory activity and membrane potential of rat liver mitochondria and inhibit oxidative processes in erythrocytes. Biomeditsinskaia khimiia. 2023 Nov; 69(5):281-289. doi: 10.18097/pbmc20236905281. [PMID: 37937430]
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