Urson (BioDeep_00000859717)

Main id: BioDeep_00000000219

 

PANOMIX_OTCML-2023


代谢物信息卡片


(1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid

化学式: C30H48O3 (456.3603)
中文名称: 熊果酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
InChI: InChI=1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1

描述信息

D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C274 - Antineoplastic Agent > C129839 - Apoptotic Pathway-targeting Antineoplastic Agent
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C26170 - Protective Agent > C275 - Antioxidant
D000893 - Anti-Inflammatory Agents
D000890 - Anti-Infective Agents
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.
Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.

同义名列表

32 个代谢物同义名

(1S,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid; Urs-12-en-28-oic acid, 3-hydroxy-, (3beta)-; Urs-12-en-28-oic acid, 3beta-hydroxy- (8CI); (3beta)-3-Hydroxyurs-12-en-28-oic acid; 3beta-Hydroxyurs-12-en-28-oic acid; 3beta-Hydroxy-12-ursen-28-ic acid; Prestwick3_000089; EINECS 201-034-0; BPBio1_000020; BSPBio_000018; Ursolic Acid; MLS000728569; SMR000445681; TOS-BB-0966; 89797_FLUKA; U6753_SIGMA; 209545-05-1; AIDS-039057; CCRIS 7123; NSC 167406; CHEBI:9908; AIDS039057; AI3-03109; ST056289; NSC 4060; NSC4060; 77-52-1; Prunol; C08988; Urson; Malol; Ursolic acid



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

763 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ANG, BCL2, CASP9, EGFR, MTOR, NOS2, PPARG, PTEN, RELA, STAT3, TP53
Peripheral membrane protein 3 ACHE, CYP1B1, MTOR
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 5 BCL2, CD4, CYP1B1, EGFR, MTOR
Nucleus 12 ACHE, ANG, BCL2, CASP9, EGFR, MTOR, NOS2, PPARG, PTEN, RELA, STAT3, TP53
cytosol 10 ANG, BCL2, CASP9, MTOR, NOS2, PPARG, PTEN, RELA, STAT3, TP53
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 1 TP53
nucleoplasm 7 MTOR, NOS2, PPARG, PTEN, RELA, STAT3, TP53
RNA polymerase II transcription regulator complex 2 PPARG, STAT3
Cell membrane 3 ACHE, CD4, EGFR
Cytoplasmic side 1 MTOR
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Golgi apparatus membrane 1 MTOR
Synapse 1 ACHE
cell junction 1 EGFR
cell surface 3 ACHE, EGFR, ICAM1
glutamatergic synapse 2 EGFR, RELA
Golgi apparatus 1 ACHE
Golgi membrane 3 EGFR, INS, MTOR
growth cone 1 ANG
lysosomal membrane 2 GAA, MTOR
neuromuscular junction 1 ACHE
neuronal cell body 1 ANG
Cytoplasm, cytosol 1 NOS2
Lysosome 2 GAA, MTOR
endosome 1 EGFR
plasma membrane 8 ACHE, CD4, EGFR, GAA, ICAM1, NOS2, PTEN, STAT3
Membrane 8 ACHE, BCL2, CYP1B1, EGFR, GAA, ICAM1, MTOR, TP53
apical plasma membrane 2 EGFR, PTEN
basolateral plasma membrane 1 EGFR
extracellular exosome 2 GAA, ICAM1
Lysosome membrane 2 GAA, MTOR
endoplasmic reticulum 2 BCL2, TP53
extracellular space 8 ACHE, ANG, CCL2, CXCL8, EGFR, ICAM1, IL10, INS
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 4 ACHE, EGFR, NOS2, PPARG
mitochondrion 4 BCL2, CASP9, CYP1B1, TP53
protein-containing complex 4 BCL2, CASP9, EGFR, TP53
intracellular membrane-bounded organelle 3 CYP1B1, GAA, PPARG
Microsome membrane 2 CYP1B1, MTOR
postsynaptic density 1 PTEN
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 3 CD4, EGFR, ICAM1
Secreted 7 ACHE, ANG, CCL2, CXCL8, GAA, IL10, INS
extracellular region 8 ACHE, ANG, CCL2, CXCL8, GAA, IL10, INS, PTEN
cytoplasmic side of plasma membrane 1 PTEN
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
Extracellular side 1 ACHE
transcription regulator complex 3 RELA, STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 2 CD4, ICAM1
actin cytoskeleton 1 ANG
dendritic spine 1 PTEN
nucleolus 2 ANG, TP53
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 1 CD4
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 3 CD4, EGFR, ICAM1
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 2 EGFR, ICAM1
Peroxisome 1 NOS2
basement membrane 2 ACHE, ANG
intracellular vesicle 1 EGFR
peroxisomal matrix 1 NOS2
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 3 MTOR, PTEN, TP53
PML body 3 MTOR, PTEN, TP53
collagen-containing extracellular matrix 1 ICAM1
receptor complex 2 EGFR, PPARG
Cell projection, neuron projection 1 PTEN
neuron projection 1 PTEN
chromatin 4 PPARG, RELA, STAT3, TP53
cell projection 1 PTEN
Chromosome 1 ANG
Nucleus, nucleolus 1 ANG
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 TP53
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
tertiary granule membrane 1 GAA
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 CD4, INS
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
endocytic vesicle 1 ANG
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Schmidt-Lanterman incisure 1 PTEN
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ICAM1
apoptosome 1 CASP9
clathrin-coated endocytic vesicle membrane 2 CD4, EGFR
[Isoform 1]: Nucleus 1 TP53
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
Cytoplasmic vesicle, phagosome 1 MTOR
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
T cell receptor complex 1 CD4
cortical cytoskeleton 1 NOS2
angiogenin-PRI complex 1 ANG
myelin sheath adaxonal region 1 PTEN
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[Isoform alpha]: Secreted 1 PTEN
NF-kappaB p50/p65 complex 1 RELA
[Isoform H]: Cell membrane 1 ACHE
NF-kappaB complex 1 RELA
caspase complex 1 CASP9


文献列表

  • Yufan Guo, Xiuru Yang, Yihong Zhang, Fazhen Luo, Juan Yang, Xupeng Zhang, Jinxia Mi, Yan Xie. Hyaluronic acid/dextran-based polymeric micelles co-delivering ursolic acid and doxorubicin to mitochondria for potentiating chemotherapy in MDR cancer. Carbohydrate polymers. 2024 May; 332(?):121897. doi: 10.1016/j.carbpol.2024.121897. [PMID: 38431408]
  • Li Chen, Yan Chen, Mengxia Wang, Linglin Lai, Linbo Zheng, Huiqin Lu. Ursolic acid alleviates cancer cachexia by inhibiting STAT3 signaling pathways in C2C12 myotube and CT26 tumor-bearing mouse model. European journal of pharmacology. 2024 Apr; 969(?):176429. doi: 10.1016/j.ejphar.2024.176429. [PMID: 38423241]
  • Lina Zhu, Yuee Tian, Tiewei Wang, Xiaobo Huang, Lin Zhou, Liu Shengming, Genqiang Chen, Zhiping Che. Semisynthesis, anti-oomycete and anti-fungal activities of ursolic acid ester derivatives. Natural product research. 2024 Mar; 38(6):906-915. doi: 10.1080/14786419.2023.2207135. [PMID: 37115170]
  • Xiao-Long Huang, Yan Sun, Peng Wen, Jun-Cheng Pan, Wei-Yang He. The potential mechanism of ursolic acid in the treatment of bladder cancer based on network pharmacology and molecular docking. The Journal of international medical research. 2024 Mar; 52(3):3000605241234006. doi: 10.1177/03000605241234006. [PMID: 38443785]
  • Edet Effiong Asanga, Ndifreke Daniel Ekpo, Affiong Asuquo Edeke, Chinedum Martins Ekeleme, Henshaw Uchechi Okoroiwu, Uwem Okon Edet, Ekementeabasi A Umoh, Nikita Elkanah Umoaffia, Olorunfemi Abraham Eseyin, Ani Nkang, Monday Akpanabiatu, Jude Efiom Okokon, Sylvia Akpotuzor, Bright Asuquo Effiong, MacGeorge Ettaba. Betulinic and ursolic acids from Nauclea latifolia roots mediate their antimalarial activities through docking with PfEMP-1 and PfPKG proteins. BMC complementary medicine and therapies. 2024 Feb; 24(1):79. doi: 10.1186/s12906-023-04324-x. [PMID: 38326823]
  • Mengzhe Zhang, Fenfen Xiang, Yipeng Sun, Rongrong Liu, Qian Li, Qing Gu, Xiangdong Kang, Rong Wu. Ursolic acid inhibits the metastasis of colon cancer by downregulating ARL4C expression. Oncology reports. 2024 02; 51(2):. doi: 10.3892/or.2023.8686. [PMID: 38131251]
  • Tzu-Kang Lin, Kun-Chieh Yeh, Ming-Shang Pai, Pei-Wen Hsieh, Su-Jane Wang. Ursolic acid inhibits the synaptic release of glutamate and prevents glutamate excitotoxicity in rats. European journal of pharmacology. 2024 Jan; 963(?):176280. doi: 10.1016/j.ejphar.2023.176280. [PMID: 38113967]
  • Tao Zhang, Fenfen Xiang, Xiaoxiao Li, Zixi Chen, Jun Wang, Jiahui Guo, Shanshan Zhu, Jun Zhou, Xiangdong Kang, Rong Wu. Mechanistic study on ursolic acid inhibiting the growth of colorectal cancer cells through the downregulation of TGF-β3 by miR-140-5p. Journal of biochemical and molecular toxicology. 2024 Jan; 38(1):e23581. doi: 10.1002/jbt.23581. [PMID: 38044485]
  • Zhen Zeng, Zhe Sun, Cheng-Ying Wu, Fang Long, Hong Shen, Jing Zhou, Song-Lin Li. Quality evaluation of Pterocephali Herba through simultaneously quantifying 18 bioactive components by UPLC-TQ-MS/MS analysis. Journal of pharmaceutical and biomedical analysis. 2023 Oct; 238(?):115828. doi: 10.1016/j.jpba.2023.115828. [PMID: 37918282]
  • Wenqi Liu, Shiwen Kang, Huijian Chen, Yerlan Bahetjan, Jinyan Zhang, Rumei Lu, Ni Zheng, Guangzhong Yang, Xinzhou Yang. A composition of ursolic acid derivatives from Ludwigia hyssopifolia induces apoptosis in throat cancer cells via the Akt/mTOR and mitochondrial signaling pathways and by modulating endoplasmic reticulum stress. Journal of ethnopharmacology. 2023 Oct; 319(Pt 3):117351. doi: 10.1016/j.jep.2023.117351. [PMID: 37884218]
  • Kensuke Iwasa, Sosuke Yagishita, Nan Yagishita-Kyo, Anzu Yamagishi, Shinji Yamamoto, Kota Yamashina, Chikara Haruta, Masashi Asai, Kei Maruyama, Kuniyoshi Shimizu, Keisuke Yoshikawa. Long term administration of loquat leaves and their major component, ursolic acid, attenuated endogenous amyloid-β burden and memory impairment. Scientific reports. 2023 10; 13(1):16770. doi: 10.1038/s41598-023-44098-3. [PMID: 37798424]
  • Guolong Li, Zhichao Du, Pingping Shen, Jian Zhang. Novel MeON-glycosides of ursolic acid: Synthesis, antitumor evaluation, and mechanism studies. Fitoterapia. 2023 Sep; 169(?):105595. doi: 10.1016/j.fitote.2023.105595. [PMID: 37355050]
  • Wenyue Wang, Tessa Sherry, Xinran Cheng, Qi Fan, Rebecca Cornell, Jie Liu, Zhicheng Xiao, Roger Pocock. An intestinal sphingolipid confers intergenerational neuroprotection. Nature cell biology. 2023 Aug; ?(?):. doi: 10.1038/s41556-023-01195-9. [PMID: 37537365]
  • Qian Liu, Yuyang Wu, Sisi Li, Somy Yoon, Jiaxin Zhang, Xiaoyi Wang, Luoshuang Hu, Chenying Su, Chunwu Zhang, Yungang Wu. Ursolic acid alleviates steroid-induced avascular necrosis of the femoral head in mouse by inhibiting apoptosis and rescuing osteogenic differentiation. Toxicology and applied pharmacology. 2023 Aug; ?(?):116649. doi: 10.1016/j.taap.2023.116649. [PMID: 37536651]
  • Ruiling Liu, Liping Zhang, Shangyue Xiao, Hangjun Chen, Yanchao Han, Ben Niu, Weijie Wu, Haiyan Gao. Ursolic acid, the main component of blueberry cuticular wax, inhibits Botrytis cinerea growth by damaging cell membrane integrity. Food chemistry. 2023 Jul; 415(?):135753. doi: 10.1016/j.foodchem.2023.135753. [PMID: 36870211]
  • Nan Huang, Qichang Xing, Wencan Li, Qingzi Yan, Renzhu Liu, Xiang Liu, Zheng Liu. Explore the mechanism of ursolic acid acting on atherosclerosis through network pharmacological and bioinformatics methods. Medicine. 2023 Jul; 102(30):e34362. doi: 10.1097/md.0000000000034362. [PMID: 37505165]
  • Ying Wang, Xiaodan Wu, Guansong Shao, Tao Wang, Zihan Wang, Bingyang Qin, Jingru Zhao, Zhiguo Liu, Yujie Fu. A cellulose-based intelligent temperature-sensitive molecularly imprinted aerogel reactor for specific recognition and enrichment of ursolic acid. Journal of chromatography. A. 2023 Jul; 1706(?):464225. doi: 10.1016/j.chroma.2023.464225. [PMID: 37541056]
  • Maiara A Daga, Scheila T Nicolau, Juliana Jurumenha-Barreto, Lucas B S Lima, Isaac L Cabral, Ana Paula Pivotto, Amanda Stefanello, João P A Amorim, Jaqueline Hoscheid, Edson A Silva, Thaís S Ayala, Rafael A Menolli. Ursolic acid-rich extract presents trypanocidal action in vitro but worsens mice under experimental acute Chagas disease. Parasite immunology. 2023 Jul; ?(?):e13005. doi: 10.1111/pim.13005. [PMID: 37467029]
  • Arina Soursouri, Seyed Mohsen Hosseini, Farnoosh Fattahi. Seasonal variations of triterpene acid contents in Viscum album L. on typical host trees of Hyrcanian forests. Scientific reports. 2023 07; 13(1):11587. doi: 10.1038/s41598-023-38649-x. [PMID: 37463985]
  • Tuba Aydin, Ruya Saglamtas, Mehmet Gumustas, Mucip Genisel, Cavit Kazaz, Ahmet Cakir. Lavandula stoechas L. subsp. stoechas, a New Herbal Source for Ursolic Acid: Quantitative Analysis, Purification and Bioactivity Studies. Chemistry & biodiversity. 2023 Jun; ?(?):e202300414. doi: 10.1002/cbdv.202300414. [PMID: 37338138]
  • Abdul Qadir, Shehla Nasar Mir Najib Ullah, Dipak Kumar Gupta, Nausheen Khan, Musarrat Husain Warsi, Mehnaz Kamal. Combinatorial drug-loaded quality by design adapted transliposome gel formulation for dermal delivery: In vitro and dermatokinetic study. Journal of cosmetic dermatology. 2023 Jun; ?(?):. doi: 10.1111/jocd.15792. [PMID: 37309263]
  • Jia Lihong, Tie Defu, Fan Zhaohui, Chen Dan, Chen Qizhu, Chen Jun, B O Huaben. Mechanism underlying Fanmugua () leaf multicomponent synergistic therapy for anemia: data mining based on hematopoietic network. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2023 Jun; 43(3):542-551. doi: 10.19852/j.cnki.jtcm.2023.03.004. [PMID: 37147756]
  • Irene Julca, Daniela Mutwil-Anderwald, Vaishnervi Manoj, Zahra Khan, Soak Kuan Lai, Lay K Yang, Ing T Beh, Jerzy Dziekan, Yoon P Lim, Shen K Lim, Yee W Low, Yuen I Lam, Seth Tjia, Yuguang Mu, Qiao W Tan, Przemyslaw Nuc, Le M Choo, Gillian Khew, Loo Shining, Antony Kam, James P Tam, Zbynek Bozdech, Maximilian Schmidt, Bjoern Usadel, Yoganathan Kanagasundaram, Saleh Alseekh, Alisdair Fernie, Hoi Y Li, Marek Mutwil. Genomic, transcriptomic, and metabolomic analysis of Oldenlandia corymbosa reveals the biosynthesis and mode of action of anti-cancer metabolites. Journal of integrative plant biology. 2023 Jun; 65(6):1442-1466. doi: 10.1111/jipb.13469. [PMID: 36807520]
  • Jingjing Shen, Yan Fu, Fanglin Liu, Bangzuo Ning, Xin Jiang. Ursolic Acid Promotes Autophagy by Inhibiting Akt/mTOR and TNF-α/TNFR1 Signaling Pathways to Alleviate Pyroptosis and Necroptosis in Mycobacterium tuberculosis-Infected Macrophages. Inflammation. 2023 May; ?(?):. doi: 10.1007/s10753-023-01839-w. [PMID: 37212951]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Zhiyao Liu, Hailiang Huang, Ying Yu, Yuqi Jia, Lingling Li, Xin Shi, Fangqi Wang. Exploring the potential mechanism of action of ursolic acid against gastric cancer and COVID-19 using network pharmacology and bioinformatics analysis. Current pharmaceutical design. 2023 May; ?(?):. doi: 10.2174/1381612829666230510124716. [PMID: 37218202]
  • Mohan Karthik, Shanmugam Manoharan, Radhakrishnan Muralinaidu. Ursolic acid-loaded chitosan nanoparticles suppress 7,12-dimethylbenz(a)anthracene-induced oral tumor formation through their antilipid peroxidative potential in golden Syrian hamsters. Naunyn-Schmiedeberg's archives of pharmacology. 2023 May; ?(?):. doi: 10.1007/s00210-023-02509-2. [PMID: 37162542]
  • Parthasarathy Arunachalam Chettiyar Kamatchi, Rajan Maheswaran, Subramaniyan Sivanandhan, Savarimuthu Ignacimuthu, Kedike Balakrishna, Appadurai Daniel Reegan, Subramanian Arivoli. Bioefficacy of ursolic acid and its derivatives isolated from Catharanthus roseus (L) G. Don leaf against Aedes aegypti, Culex quinquefasciatus, and Anopheles stephensi larvae. Environmental science and pollution research international. 2023 May; ?(?):. doi: 10.1007/s11356-023-27253-1. [PMID: 37133656]
  • Md Yousof Ali, Se Eun Park, Su Hui Seong, Gerald W Zamponi, Hyun Ah Jung, Jae Sue Choi. Ursonic acid from Artemisia montana exerts anti-diabetic effects through anti-glycating properties, and by inhibiting PTP1B and activating the PI3K/Akt signaling pathway in insulin-resistant C2C12 cells. Chemico-biological interactions. 2023 May; 376(?):110452. doi: 10.1016/j.cbi.2023.110452. [PMID: 36933777]
  • Guirong Chen, Chang Liu, Mingbo Zhang, Xiaobo Wang. [Study on the anti-sepsis mechanism of ursolic acid by targeting myeloid differentiation protein-2]. Zhonghua wei zhong bing ji jiu yi xue. 2023 May; 35(5):476-481. doi: 10.3760/cma.j.cn121430-20220705-00634. [PMID: 37308226]
  • Amanda Kornel, Matteo Nadile, Maria Ilektra Retsidou, Minas Sakellakis, Katerina Gioti, Apostolos Beloukas, Newman Siu Kwan Sze, Panagiota Klentrou, Evangelia Tsiani. Ursolic Acid against Prostate and Urogenital Cancers: A Review of In Vitro and In Vivo Studies. International journal of molecular sciences. 2023 Apr; 24(8):. doi: 10.3390/ijms24087414. [PMID: 37108576]
  • Fan Xu, Minghua Li, Zujun Que, Mingliang Su, Wang Yao, Yu Zhang, Bin Luo, Yan Li, Zhanxia Zhang, Jianhui Tian. Combined chemo-immuno-photothermal therapy based on ursolic acid/astragaloside IV-loaded hyaluronic acid-modified polydopamine nanomedicine inhibiting the growth and metastasis of non-small cell lung cancer. Journal of materials chemistry. B. 2023 Apr; ?(?):. doi: 10.1039/d2tb02328h. [PMID: 37009696]
  • Zhehuan Wang, Huiru Zhang, Caihong Qi, Hui Guo, Xiangyue Jiao, Jia Yan, Yifei Wang, Qiangsheng Li, Mingming Zhao, Xinhao Guo, Baoluo Wan, Xiaotian Li. Ursolic acid ameliorates DNCB-induced atopic dermatitis-like symptoms in mice by regulating TLR4/NF-κB and Nrf2/HO-1 signaling pathways. International immunopharmacology. 2023 Mar; 118(?):110079. doi: 10.1016/j.intimp.2023.110079. [PMID: 36996741]
  • Brice Maxime Nkouayeb Nangmou, Hermine Laure Maza Djomkam, Georges Bellier Tabekoueng, Willifred Dongmo Tékapi Tsopgni, Gabin Thierry Mbahbou Bitchagno, Michel Arnaud Mbock, Raceline Gounoue Kamkumo, Marcel Frese, Bruno Ndjakou Lenta, Silvère Augustin Ngouela, Nobert Sewald, Anatole Guy Blaise Azebaze. Bioguided Fractionation and Isolation of an Antiplasmodial Saponin from the Roots of Nauclea xanthoxylon (A.Chev.) Aubrév. (Rubiaceae). Chemistry & biodiversity. 2023 Mar; ?(?):e202200271. doi: 10.1002/cbdv.202200271. [PMID: 36890112]
  • Ke Jin, Xun Shi, Jiaheng Liu, Wenwen Yu, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Long Liu. Combinatorial metabolic engineering enables the efficient production of ursolic acid and oleanolic acid in Saccharomyces cerevisiae. Bioresource technology. 2023 Mar; 374(?):128819. doi: 10.1016/j.biortech.2023.128819. [PMID: 36868430]
  • Hui Zhao, Shun Tang, Qiu Tao, Tianqi Ming, Jiarong Lei, Yuanjing Liang, Yuhui Peng, Minmin Wang, Maolun Liu, Han Yang, Shan Ren, Haibo Xu. Ursolic Acid Suppresses Colorectal Cancer by Down-Regulation of Wnt/β-Catenin Signaling Pathway Activity. Journal of agricultural and food chemistry. 2023 Feb; ?(?):. doi: 10.1021/acs.jafc.2c06775. [PMID: 36826439]
  • Chunyan Li, Chunhuan Ren, Yale Chen, Mingming Wang, Jun Tang, Yan Zhang, Qiangjun Wang, Zijun Zhang. Changes on proteomic and metabolomic profiling of cryopreserved sperm effected by melatonin. Journal of proteomics. 2023 02; 273(?):104791. doi: 10.1016/j.jprot.2022.104791. [PMID: 36538967]
  • Sarra Kefi, Rym Essid, Adele Papetti, Ghassen Abid, Lamjed Bouslama, Ezzedine Aouani, Olfa Tabbene, Ferid Limam. Antioxidant, antibacterial, and antileishmanial potential of Micromeria nervosa extracts and molecular mechanism of action of the bioactive compound. Journal of applied microbiology. 2023 Feb; 134(2):. doi: 10.1093/jambio/lxad007. [PMID: 36649680]
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