Umbelliferone (BioDeep_00000000007)

 

Secondary id: BioDeep_00000400511, BioDeep_00000422454, BioDeep_00000861538

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite natural product


代谢物信息卡片


7-Hydroxy-2H-1-benzopyran-2-one

化学式: C9H6O3 (162.0317)
中文名称: 伞形酮, 7-羟基香豆素
谱图信息: 最多检出来源 Homo sapiens(blood) 19.24%

Reviewed

Last reviewed on 2024-07-12.

Cite this Page

Umbelliferone. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/umbelliferone (retrieved 2024-12-21) (BioDeep RN: BioDeep_00000000007). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1=CC(=CC2=C1C=CC(=O)O2)O
InChI: InChI=1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H

描述信息

Umbelliferone is a hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7. It has a role as a fluorescent probe, a plant metabolite and a food component.
Umbelliferone is a natural product found in Ficus septica, Artemisia ordosica, and other organisms with data available.
See also: Chamomile (part of).
Occurs widely in plants including Angelica subspecies Phytoalexin of infected sweet potato. Umbelliferone is found in many foods, some of which are macadamia nut, silver linden, quince, and capers.
Umbelliferone is found in anise. Umbelliferone occurs widely in plants including Angelica species Phytoalexin of infected sweet potat
A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.

[Raw Data] CB220_Umbelliferone_pos_50eV_CB000077.txt
[Raw Data] CB220_Umbelliferone_pos_40eV_CB000077.txt
[Raw Data] CB220_Umbelliferone_pos_30eV_CB000077.txt
[Raw Data] CB220_Umbelliferone_pos_10eV_CB000077.txt
[Raw Data] CB220_Umbelliferone_pos_20eV_CB000077.txt
[Raw Data] CB220_Umbelliferone_neg_40eV_000039.txt
[Raw Data] CB220_Umbelliferone_neg_10eV_000039.txt
[Raw Data] CB220_Umbelliferone_neg_30eV_000039.txt
[Raw Data] CB220_Umbelliferone_neg_20eV_000039.txt

Umbelliferone. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=93-35-6 (retrieved 2024-07-12) (CAS RN: 93-35-6). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Umbelliferone (7-Hydroxycoumarin), a natural product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent.
Umbelliferone (7-Hydroxycoumarin), a natural product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent.

同义名列表

68 个代谢物同义名

Umbelliferone; Umbelliferone, suitable for fluorescence indicator, >=98.0\\% (HPLC); InChI=1/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10; Umbelliferone, Vetec(TM) reagent grade, 98\\%; 5-18-01-00386 (Beilstein Handbook Reference); 7-Hydroxycoumarin;Hydrangin;NSC 19790; Umbelliferone (Hydrangin, Skimmetin); Umbelliferone, analytical standard; 2H-1-Benzopyran-2-one, 7-hydroxy-; 7-Hydroxy-2H-1-benzopyran-2-one; 7-hydroxycoumarin, 14C-labeled; 7-Hydroxy-2H-chromen-2-one #; 7-hydroxy-1-benzopyran-2-one; 7-Hydroxy-2H-chromen-2-one; 7-hydroxycoumarin sulphate; 2-Hydroxy-7H-chromen-7-one; 7-hydroxycoumarin sulfate; Coumarin derivative, 3a; 7-Hydroxy Coumarin ,(S); 7-oxidanylchromen-2-one; 7-hydroxy-chromen-2-one; 7-hydroxychromen-2-one; UMBELLIFERONE [WHO-DD]; 7-Hydroxy-2-chromenone; .beta.-Umbelliferone; Coumarin, 7-hydroxy-; beta -umbelliferone; Umbelliferone, 99\\%; 7-hydroxy-coumarine; 7-hydroxycournarin; 7-hydroxy-coumarin; 7-hydroxycoumarine; 7-hydroxy coumarin; beta-Umbelliferone; UMBELLIFERONE [MI]; 7-Hydroxycoumarin; Spectrum3_000751; Spectrum2_001962; 7-hydroxycumarin; UNII-60Z60NTL4G; b-Umbelliferone; Β-umbelliferone; 7 OH COUMARIN; Umbelliferone; MEGxp0_000814; 7-Oxycoumarin; NCI60_001646; ACon1_000219; KBio3_001582; Umbelliferon; 60Z60NTL4G; Hydrangine; Skimmetine; Dichrin A; Skimmetin; Hydrangin; AI3-38054; 1ST11436; 7-HC; 7 HC; 07L; Umbelliferone; 7-Hydroxy-2H-1-benzopyran-2-one; 7-Oxycoumarin; Skimmetin; Hydrangin; NSC 19790; Umbelliferone



数据库引用编号

53 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(7)

PlantCyc(6)

代谢反应

624 个相关的代谢反应过程信息。

Reactome(55)

BioCyc(8)

WikiPathways(0)

Plant Reactome(246)

INOH(0)

PlantCyc(315)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1103 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ALB, BCL2, CASP3, CAT, CYP2A6, CYP2E1, CYP3A4, MAPK14, NFE2L2, NOS2, PPARG, PTGS2, TLR4
Peripheral membrane protein 5 ACHE, CYP1B1, CYP2E1, GORASP1, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 7 BCL2, CYP1B1, CYP2A6, CYP2E1, CYP3A4, HMOX1, PTGS2
Nucleus 9 ACHE, ALB, BCL2, CASP3, HMOX1, MAPK14, NFE2L2, NOS2, PPARG
cytosol 9 ALB, BCL2, CASP3, CAT, HMOX1, MAPK14, NFE2L2, NOS2, PPARG
centrosome 2 ALB, NFE2L2
nucleoplasm 6 CASP3, HMOX1, MAPK14, NFE2L2, NOS2, PPARG
RNA polymerase II transcription regulator complex 2 NFE2L2, PPARG
Cell membrane 3 ACHE, TLR4, TNF
Cytoplasmic side 2 GORASP1, HMOX1
Golgi apparatus membrane 1 GORASP1
Synapse 1 ACHE
cell surface 3 ACHE, TLR4, TNF
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 4 ACHE, ALB, GORASP1, NFE2L2
Golgi membrane 2 GORASP1, INS
mitochondrial inner membrane 1 CYP2E1
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
Cytoplasm, cytosol 2 NFE2L2, NOS2
plasma membrane 5 ACHE, NFE2L2, NOS2, TLR4, TNF
Membrane 8 ACHE, BCL2, CAT, CYP1B1, CYP2A6, CYP3A4, HMOX1, TLR4
caveola 1 PTGS2
extracellular exosome 2 ALB, CAT
endoplasmic reticulum 4 ALB, BCL2, HMOX1, PTGS2
extracellular space 6 ACHE, ALB, HMOX1, IL6, INS, TNF
perinuclear region of cytoplasm 5 ACHE, HMOX1, NOS2, PPARG, TLR4
mitochondrion 4 BCL2, CAT, CYP1B1, MAPK14
protein-containing complex 4 ALB, BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 6 CAT, CYP1B1, CYP2A6, CYP2E1, CYP3A4, PPARG
Microsome membrane 4 CYP1B1, CYP2E1, CYP3A4, PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 TLR4
Secreted 4 ACHE, ALB, IL6, INS
extracellular region 7 ACHE, ALB, CAT, IL6, INS, MAPK14, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
anchoring junction 1 ALB
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 TLR4, TNF
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 NOS2
Mitochondrion inner membrane 1 CYP2E1
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 CAT
cis-Golgi network 1 GORASP1
Peroxisome 2 CAT, NOS2
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 PPARG, TLR4
neuron projection 1 PTGS2
ciliary basal body 1 ALB
chromatin 2 NFE2L2, PPARG
mediator complex 1 NFE2L2
phagocytic cup 2 TLR4, TNF
centriole 1 ALB
spindle pole 2 ALB, MAPK14
blood microparticle 1 ALB
Lipid-anchor, GPI-anchor 1 ACHE
endosome lumen 1 INS
side of membrane 1 ACHE
myelin sheath 1 BCL2
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, IL6, INS, PTGS2
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
cytoplasmic microtubule 1 CYP2A6
synaptic cleft 1 ACHE
protein-DNA complex 1 NFE2L2
death-inducing signaling complex 1 CASP3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[Isoform H]: Cell membrane 1 ACHE
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yuanyuan Chen, Xikun Liu, Jie Ma, Weida Wang, Zhaojun Li, Haijie Wu, Zhanxi Lu, Dongming Zhang, Xiaoying Zhang, Yu Zhang, Sen Zhang. Hydrangea paniculata coumarins alleviate adriamycin-induced renal lipotoxicity through activating AMPK and inhibiting C/EBPβ. Journal of ethnopharmacology. 2024 Jul; 329(?):118156. doi: 10.1016/j.jep.2024.118156. [PMID: 38583729]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Tong Jin, Cheng Chen. Umbelliferone delays the progression of diabetic nephropathy by inhibiting ferroptosis through activation of the Nrf-2/HO-1 pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022 May; 163(?):112892. doi: 10.1016/j.fct.2022.112892. [PMID: 35278496]
  • Mohamed A M Allam, Akef A Khowailed, Samah Elattar, Ayman M Mahmoud. Umbelliferone ameliorates oxidative stress and testicular injury, improves steroidogenesis and upregulates peroxisome proliferator-activated receptor gamma in type 2 diabetic rats. The Journal of pharmacy and pharmacology. 2022 Apr; 74(4):573-584. doi: 10.1093/jpp/rgab083. [PMID: 34156072]
  • Mirosław Zagaja, Anna Zagaja, Joanna Szala-Rycaj, Aleksandra Szewczyk, Marta Kinga Lemieszek, Grzegorz Raszewski, Marta Andres-Mach. Influence of Umbelliferone on the Anticonvulsant and Neuroprotective Activity of Selected Antiepileptic Drugs: An In Vivo and In Vitro Study. International journal of molecular sciences. 2022 Mar; 23(7):. doi: 10.3390/ijms23073492. [PMID: 35408852]
  • Zongmei Wu, Yana Geng, Manon Buist-Homan, Han Moshage. Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress. Toxicology and applied pharmacology. 2022 02; 436(?):115858. doi: 10.1016/j.taap.2021.115858. [PMID: 34979142]
  • Jian-Wei Zhang, Yuan Xiong, Feng Wang, Fu-Mao Zhang, Xiaodi Yang, Guo-Qiang Lin, Ping Tian, Guangbo Ge, Dingding Gao. Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CLpro inhibitors for treating COVID-19. European journal of medicinal chemistry. 2022 Jan; 228(?):114030. doi: 10.1016/j.ejmech.2021.114030. [PMID: 34883292]
  • Tajpreet Kaur, Damanpreet Singh, Devendra Pathak, Amrit P Singh, Balbir Singh. Umbelliferone attenuates glycerol-induced myoglobinuric acute kidney injury through peroxisome proliferator-activated receptor-γ agonism in rats. Journal of biochemical and molecular toxicology. 2021 Nov; 35(11):e22892. doi: 10.1002/jbt.22892. [PMID: 34409680]
  • Xuezhe Piao, Hee Sun Byun, So-Ra Lee, Eunjin Ju, Kyeong Ah Park, Kyung-Cheol Sohn, Khong Trong Quan, Jinbae Lee, MinKyun Na, Gang Min Hur. 8-Geranylumbelliferone isolated from Paramignya trimera triggers RIPK1/RIPK3-dependent programmed cell death upon TNFR1 ligation. Biochemical pharmacology. 2021 10; 192(?):114733. doi: 10.1016/j.bcp.2021.114733. [PMID: 34411570]
  • Fares E M Ali, Emad H M Hassanein, Ali H El-Bahrawy, Zainab M M Omar, Eman K Rashwan, Basil A Abdel-Wahab, Tarek H Abd-Elhamid. Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways. Journal of biochemical and molecular toxicology. 2021 May; 35(5):e22738. doi: 10.1002/jbt.22738. [PMID: 33522649]
  • Peng-Chao Huo, Xiao-Qing Guan, Peng Liu, Yun-Qing Song, Meng-Ru Sun, Rong-Jing He, Li-Wei Zou, Li-Juan Xue, Jin-Hui Shi, Nan Zhang, Zhi-Guo Liu, Guang-Bo Ge. Design, synthesis and biological evaluation of indanone-chalcone hybrids as potent and selective hCES2A inhibitors. European journal of medicinal chemistry. 2021 Jan; 209(?):112856. doi: 10.1016/j.ejmech.2020.112856. [PMID: 33007602]
  • Peng-Chao Huo, Qing Hu, Sheng Shu, Qi-Hang Zhou, Rong-Jing He, Jie Hou, Xiao-Qing Guan, Dong-Zhu Tu, Xu-Dong Hou, Peng Liu, Nan Zhang, Zhi-Guo Liu, Guang-Bo Ge. Design, synthesis and biological evaluation of novel chalcone-like compounds as potent and reversible pancreatic lipase inhibitors. Bioorganic & medicinal chemistry. 2021 01; 29(?):115853. doi: 10.1016/j.bmc.2020.115853. [PMID: 33214035]
  • Yang-Liu Xia, Jing-Jing Wang, Shi-Yang Li, Yong Liu, Frank J Gonzalez, Ping Wang, Guang-Bo Ge. Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment. Bioorganic & medicinal chemistry. 2021 01; 29(?):115851. doi: 10.1016/j.bmc.2020.115851. [PMID: 33218896]
  • Joanna Sumorek-Wiadro, Adrian Zając, Ewa Langner, Krystyna Skalicka-Woźniak, Aleksandra Maciejczyk, Wojciech Rzeski, Joanna Jakubowicz-Gil. Antiglioma Potential of Coumarins Combined with Sorafenib. Molecules (Basel, Switzerland). 2020 Nov; 25(21):. doi: 10.3390/molecules25215192. [PMID: 33171577]
  • Jae-Sung Park, Beomkoo Chung, Won-Hee Lee, Jayho Lee, Youngbae Suh, Dong-Chan Oh, Ki-Bong Oh, Jongheon Shin. Sortase A-Inhibitory Coumarins from the Folk Medicinal Plant Poncirus trifoliata. Journal of natural products. 2020 10; 83(10):3004-3011. doi: 10.1021/acs.jnatprod.0c00551. [PMID: 32996318]
  • Merhan O Hindam, Rabab H Sayed, Krystyna Skalicka-Woźniak, Barbara Budzyńska, Nesrine S El Sayed. Xanthotoxin and umbelliferone attenuate cognitive dysfunction in a streptozotocin-induced rat model of sporadic Alzheimer's disease: The role of JAK2/STAT3 and Nrf2/HO-1 signalling pathway modulation. Phytotherapy research : PTR. 2020 Sep; 34(9):2351-2365. doi: 10.1002/ptr.6686. [PMID: 32250498]
  • Rubén Seoane-Rivero, Estibaliz Ruiz-Bilbao, Rodrigo Navarro, José Manuel Laza, José María Cuevas, Beñat Artetxe, Juan M Gutiérrez-Zorrilla, José Luis Vilas-Vilela, Ángel Marcos-Fernandez. Structural Characterization of Mono and Dihydroxylated Umbelliferone Derivatives. Molecules (Basel, Switzerland). 2020 Jul; 25(15):. doi: 10.3390/molecules25153497. [PMID: 32751979]
  • Adnan Amin, Muhammad Hanif, Khizar Abbas, Muhammad Ramzan, Abdur Rasheed, Ali Zaman, Luc Pieters. Studies on effects of umbelliferon derivatives against periodontal bacteria; antibiofilm, inhibition of quorum sensing and molecular docking analysis. Microbial pathogenesis. 2020 Jul; 144(?):104184. doi: 10.1016/j.micpath.2020.104184. [PMID: 32304793]
  • Yao Fu, Xiaoxiao Tian, Lingling Han, Yilin Li, Ying Peng, Jiang Zheng. Mechanism-based inactivation of cytochrome P450 2D6 by Notopterol. Chemico-biological interactions. 2020 May; 322(?):109053. doi: 10.1016/j.cbi.2020.109053. [PMID: 32198085]
  • Wei-Feng Wu, Jia-Nan Wang, Zeng Li, Biao Wei, Juan Jin, Li Gao, Hai-Di Li, Jun Li, Hai-Yong Chen, Xiao-Ming Meng. 7-Hydroxycoumarin protects against cisplatin-induced acute kidney injury by inhibiting necroptosis and promoting Sox9-mediated tubular epithelial cell proliferation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Apr; 69(?):153202. doi: 10.1016/j.phymed.2020.153202. [PMID: 32169782]
  • Xueqin Jiang, Zengjin Liu, Youzhe Yang, Hao Li, Xiaoyi Qi, Wen Xiu Ren, Mingming Deng, Muhan Lü, Jianming Wu, Sicheng Liang. A mitochondria-targeted two-photon fluorescent probe for sensing and imaging pH changes in living cells. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Jan; 224(?):117435. doi: 10.1016/j.saa.2019.117435. [PMID: 31400745]
  • Mohammed F Alotaibi, Fakhria Al-Joufi, Howida S Abou Seif, Mohammed A Alzoghaibi, Laiche Djouhri, Ahmad F Ahmeda, Ayman M Mahmoud. Umbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation, and Improving Nrf2/HO-1 Signaling. Drug design, development and therapy. 2020; 14(?):4003-4019. doi: 10.2147/dddt.s265636. [PMID: 33061305]
  • Tomonori Miura, Yusuke Kamiya, Shiori Hina, Yui Kobayashi, Norie Murayama, Makiko Shimizu, Hiroshi Yamazaki. Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model. The Journal of toxicological sciences. 2020; 45(11):695-700. doi: 10.2131/jts.45.695. [PMID: 33132243]
  • Su Hui Seong, Md Yousof Ali, Hyun Ah Jung, Jae Sue Choi. Umbelliferone derivatives exert neuroprotective effects by inhibiting monoamine oxidase A, self-amyloidβ aggregation, and lipid peroxidation. Bioorganic chemistry. 2019 11; 92(?):103293. doi: 10.1016/j.bioorg.2019.103293. [PMID: 31557622]
  • Ruben Vanholme, Lisa Sundin, Keletso Carol Seetso, Hoon Kim, Xinyu Liu, Jin Li, Barbara De Meester, Lennart Hoengenaert, Geert Goeminne, Kris Morreel, Jurgen Haustraete, Huei-Hsuan Tsai, Wolfgang Schmidt, Bartel Vanholme, John Ralph, Wout Boerjan. COSY catalyses trans-cis isomerization and lactonization in the biosynthesis of coumarins. Nature plants. 2019 10; 5(10):1066-1075. doi: 10.1038/s41477-019-0510-0. [PMID: 31501530]
  • Jia-Hao Lee, Hui-Ching Mei, I-Chih Kuo, Tzong-Huei Lee, Yu-Hsin Chen, Ching-Kuo Lee. Characterizing Tyrosinase Modulators from the Roots of Angelica keiskei Using Tyrosinase Inhibition Assay and UPLC-MS/MS as the Combinatorial Novel Approach. Molecules (Basel, Switzerland). 2019 Sep; 24(18):. doi: 10.3390/molecules24183297. [PMID: 31510069]
  • Yoon Young Kang, Jihyeon Song, Jun Yeong Kim, Heesun Jung, Woon-Seok Yeo, Yoongho Lim, Hyejung Mok. Byakangelicin as a modulator for improved distribution and bioactivity of natural compounds and synthetic drugs in the brain. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Sep; 62(?):152963. doi: 10.1016/j.phymed.2019.152963. [PMID: 31128487]
  • Xiaoyi Qi, Tongyi Dou, Zhongqiong Wang, Jianming Wu, Ling Yang, Su Zeng, Mingming Deng, Muhan Lü, Sicheng Liang. Inhibition of human cytochrome P450 2A6 by 7-hydroxycoumarin analogues: Analysis of the structure-activity relationship and isoform selectivity. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2019 Aug; 136(?):104944. doi: 10.1016/j.ejps.2019.05.022. [PMID: 31163215]
  • Mireia Casasampere, Núria Bielsa, Daniel Riba, Laura Bassas, Ruijuan Xu, Cungui Mao, Gemma Fabriàs, José-Luis Abad, Antonio Delgado, Josefina Casas. New fluorogenic probes for neutral and alkaline ceramidases. Journal of lipid research. 2019 06; 60(6):1174-1181. doi: 10.1194/jlr.d092759. [PMID: 30926626]
  • Serena Fiorito, Federica Ianni, Francesca Preziuso, Francesco Epifano, Luca Scotti, Tonino Bucciarelli, Salvatore Genovese. UHPLC-UV/Vis Quantitative Analysis of Hydroxylated and O-prenylated Coumarins in Pomegranate Seed Extracts. Molecules (Basel, Switzerland). 2019 May; 24(10):. doi: 10.3390/molecules24101963. [PMID: 31121819]
  • Han-Qing Wang, Sha-Sha Wang, Kuok Chiufai, Qi Wang, Xiao-Lan Cheng. Umbelliferone ameliorates renal function in diabetic nephropathy rats through regulating inflammation and TLR/NF-κB pathway. Chinese journal of natural medicines. 2019 May; 17(5):346-354. doi: 10.1016/s1875-5364(19)30040-8. [PMID: 31171269]
  • Qingpeng Wang, Yan Chen, Guoshuai Li, Zhifang Liu, Jing Ma, Min Liu, Dacheng Li, Jun Han, Bingquan Wang. Synthesis and evaluation of bi-functional 7-hydroxycoumarin platinum(IV) complexes as antitumor agents. Bioorganic & medicinal chemistry. 2019 05; 27(10):2112-2121. doi: 10.1016/j.bmc.2019.04.009. [PMID: 30981607]
  • Dan Li, Zhuoliang Gu, Jingdong Zhang, Shuren Ma. Protective effect of inducible aldo-keto reductases on 4-hydroxynonenal- induced hepatotoxicity. Chemico-biological interactions. 2019 May; 304(?):124-130. doi: 10.1016/j.cbi.2019.02.012. [PMID: 30849339]
  • Zhang Sen, Wang Weida, Ma Jie, Sheng Li, Zhang Dongming, Chen Xiaoguang. Coumarin glycosides from Hydrangea paniculata slow down the progression of diabetic nephropathy by targeting Nrf2 anti-oxidation and smad2/3-mediated profibrosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Apr; 57(?):385-395. doi: 10.1016/j.phymed.2018.12.045. [PMID: 30849675]
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