Emodin (BioDeep_00000398712)

   

natural product PANOMIX_OTCML-2023 Antitumor activity


代谢物信息卡片


9,10-Anthracenedione, 1,3,8-trihydroxy-6-methyl- (9CI)

化学式: C15H10O5 (270.0528)
中文名称: 大黄素
谱图信息: 最多检出来源 Viridiplantae(plant) 86.02%

分子结构信息

SMILES: CC1=CC(=C2C(=C1)C(=O)C3=CC(=CC(=C3C2=O)O)O)O
InChI: InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3

描述信息

C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
D005765 - Gastrointestinal Agents > D002400 - Cathartics
CONFIDENCE isolated standard
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.288
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.291
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.286
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.293
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].

同义名列表

81 个代谢物同义名

9,10-Anthracenedione, 1,3,8-trihydroxy-6-methyl- (9CI); 9,10-Anthracenedione, 1,3,8-trihydroxy-6-methyl-; 1,3,8-trihydroxy-6-methyl-anthracene-9,10-dione; Anthraquinone, 1,3,8-trihydroxy-6-methyl- (8CI); 1,3,8-trihydroxy-6-methylanthracene-9,10-dione; Emodin; 6-Methyl-1,3,8-trihydroxyanthraquinone; 6-Methyl-1,3,8-trihydroxy-9,10-anthracenedione; 1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione; 1,3,8-Trihydroxy-6-methyl-9,10-anthraquinone; 6-Methyl-1,3,8-tri- hydroxy- anthra- quinone; 1,3,8-Tri- hydroxy-6-methyl- anthra- quinone; 1,3,8-Trihydroxy-6-methylanthra-9,10-quinone; 4-08-00-03575 (Beilstein Handbook Reference); Anthraquinone, 6-methyl-1,3,8-trihydroxy-; Anthraquinone, 1,3,8-trihydroxy-6-methyl-; 3-Methyl-1,6,8-trihydroxyanthraquinone; 6-Methyl-1,3,8-trihydroxyanthraquinone; 1,3,8-Trihydroxy-6-methylanthraquinone; 4,5,7-Trihydroxy-2-methylanthraquinone; C.I. Natural Yellow 14; Persian Berry Lake; Spectrum2_000895; EINECS 208-258-8; Spectrum5_000614; Spectrum3_000742; Spectrum4_001757; Spectrum_001954; NCGC00091540-05; NCGC00015420-02; SpecPlus_000332; Frangula emodin; NCGC00091540-01; Frangula-emodin; NCGC00015420-01; NCIMech_000049; BSPBio_002324; DivK1c_006428; KBioSS_002508; Lopac0_000552; MEGxp0_000460; KBioGR_002234; MLS001066370; ZINC03824868; Rheum emodin; KBio1_001372; SMR000326798; KBio3_001544; KBio2_007636; KBio2_005068; NCI60_003906; LMPK02000037; KBio2_002500; ACon1_001939; Lopac-E-7881; SPBio_000710; SMP2_000211; CHEBI:42223; BRN 1888141; 45170_FLUKA; AIDS-001392; E7881_SIGMA; NSC 622947; NSC 408120; AIDS001392; EU-0100552; Schuttgelb; CCRIS 3528; C.I. 75440; HSDB 7093; NSC408120; NSC622947; AI3-38286; TNP00318; 518-82-1; ST055355; Emodin; C10343; K00056; Emodol; EMO; Emodin



相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

671 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
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  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表
Cytoplasm 12 AKT1, ALB, CASP1, CDKN1A, EGFR, ERBB2, HIF1A, MAPK1, MTOR, PRKAA2, STAT3, TP53
Peripheral membrane protein 2 CYP1B1, MTOR
Endosome membrane 2 EGFR, ERBB2
Endoplasmic reticulum membrane 3 CYP1B1, EGFR, MTOR
Nucleus 12 AKT1, ALB, CDKN1A, EGFR, ERBB2, HIF1A, MAPK1, MTOR, PPARA, PRKAA2, STAT3, TP53
cytosol 12 AKT1, ALB, CASP1, CDKN1A, ERBB2, GPT, HIF1A, MAPK1, MTOR, PRKAA2, STAT3, TP53
dendrite 2 MTOR, PRKAA2
nuclear body 2 CDKN1A, HIF1A
phagocytic vesicle 1 MTOR
centrosome 3 ALB, MAPK1, TP53
nucleoplasm 10 AKT1, CDKN1A, ERBB2, HIF1A, MAPK1, MTOR, PPARA, PRKAA2, STAT3, TP53
RNA polymerase II transcription regulator complex 2 HIF1A, STAT3
Cell membrane 5 AKT1, CASP1, EGFR, ERBB2, TNF
Cytoplasmic side 1 MTOR
lamellipodium 1 AKT1
ruffle membrane 2 EGFR, ERBB2
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 ABCC2
Golgi apparatus membrane 1 MTOR
Synapse 1 MAPK1
cell cortex 1 AKT1
cell junction 1 EGFR
cell surface 3 ABCC2, EGFR, TNF
glutamatergic synapse 2 AKT1, EGFR
Golgi apparatus 3 ALB, MAPK1, PRKAA2
Golgi membrane 2 EGFR, MTOR
lysosomal membrane 1 MTOR
neuromuscular junction 1 ERBB2
neuronal cell body 2 PRKAA2, TNF
postsynapse 1 AKT1
presynaptic membrane 1 ERBB2
Lysosome 1 MTOR
endosome 1 EGFR
plasma membrane 8 ABCC2, AKT1, CASP1, EGFR, ERBB2, MAPK1, STAT3, TNF
Membrane 8 ABCC2, AKT1, CYP1B1, EGFR, ERBB2, MTOR, PRKAA2, TP53
apical plasma membrane 3 ABCC2, EGFR, ERBB2
axon 1 PRKAA2
basolateral plasma membrane 2 EGFR, ERBB2
caveola 1 MAPK1
extracellular exosome 2 ALB, GPT
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 ALB, TP53
extracellular space 6 ALB, EGFR, IL17A, IL4, IL6, TNF
perinuclear region of cytoplasm 3 CDKN1A, EGFR, ERBB2
intercellular canaliculus 1 ABCC2
mitochondrion 3 CYP1B1, MAPK1, TP53
protein-containing complex 7 AKT1, ALB, CASP1, CDKN1A, EGFR, HIF1A, TP53
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 2 CYP1B1, MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 EGFR, ERBB2
Secreted 4 ALB, IL17A, IL4, IL6
extracellular region 7 ALB, ERBB2, IL17A, IL4, IL6, MAPK1, TNF
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
anchoring junction 1 ALB
transcription regulator complex 2 STAT3, TP53
motile cilium 1 HIF1A
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 MAPK1, TP53
nuclear membrane 1 EGFR
external side of plasma membrane 2 IL17A, TNF
cytoplasmic vesicle 1 ERBB2
microtubule cytoskeleton 1 AKT1
nucleolus 3 CASP1, CDKN1A, TP53
axon cytoplasm 1 HIF1A
Early endosome 2 ERBB2, MAPK1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Apical cell membrane 1 ABCC2
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
Membrane raft 2 EGFR, TNF
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton 1 TP53
Cytoplasm, cytoskeleton, spindle 1 MAPK1
focal adhesion 2 EGFR, MAPK1
microtubule 1 CASP1
spindle 2 AKT1, MAPK1
intracellular vesicle 1 EGFR
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
nuclear speck 2 HIF1A, PRKAA2
NLRP3 inflammasome complex 1 CASP1
Late endosome 1 MAPK1
receptor complex 2 EGFR, ERBB2
ciliary basal body 2 AKT1, ALB
chromatin 4 HIF1A, PPARA, STAT3, TP53
phagocytic cup 1 TNF
mitotic spindle 1 MAPK1
cytoskeleton 1 MAPK1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
site of double-strand break 1 TP53
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
Membrane, caveola 1 MAPK1
cytoplasmic stress granule 1 PRKAA2
Nucleus speckle 1 HIF1A
euchromatin 1 HIF1A
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 ERBB2
pseudopodium 1 MAPK1
basal plasma membrane 2 EGFR, ERBB2
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 MAPK1
endoplasmic reticulum lumen 3 ALB, IL6, MAPK1
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 ALB
azurophil granule lumen 1 MAPK1
semaphorin receptor complex 1 ERBB2
AIM2 inflammasome complex 1 CASP1
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 TP53
canonical inflammasome complex 1 CASP1
[Isoform 1]: Cell membrane 1 ERBB2
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, phagosome 1 MTOR
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
ERBB3:ERBB2 complex 1 ERBB2
interleukin-6 receptor complex 1 IL6
PCNA-p21 complex 1 CDKN1A
IPAF inflammasome complex 1 CASP1
NLRP1 inflammasome complex 1 CASP1
protease inhibitor complex 1 CASP1
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Wei Huang, Peiting Zhou, Xinyun Zou, Yunchuan Liu, Longfu Zhou, Yaolei Zhang. Emodin ameliorates myocardial fibrosis in mice by inactivating the ROS/PI3K/Akt/mTOR axis. Clinical and experimental hypertension (New York, N.Y. : 1993). 2024 Dec; 46(1):2326022. doi: 10.1080/10641963.2024.2326022. [PMID: 38507311]
  • Lu Liu, Sen Sun, Xiaohua Li. Physcion inhibition of CYP2C9, 2D6 and 3A4 in human liver microsomes. Pharmaceutical biology. 2024 Dec; 62(1):207-213. doi: 10.1080/13880209.2024.2314089. [PMID: 38353248]
  • Huang-Fei Jin, Qian-Xue Shen, Ying Shi, Fang-Ming Liu, Bin Wang, Jun Cao, Li-Hong Ye. Magnetic-stirring-enhanced mechanical amorphous dispersion extraction for the hydrophobic phytochemical constituents using an aqueous solution from a medicinal plant. Journal of pharmaceutical and biomedical analysis. 2024 Aug; 245(?):116191. doi: 10.1016/j.jpba.2024.116191. [PMID: 38728950]
  • Antonio R da Cunha, Evandro L Duarte, Gabriel S Vignoli Muniz, Kaline Coutinho, M Teresa Lamy. New insights into the interaction of emodin with lipid membranes. Biophysical chemistry. 2024 Jun; 309(?):107233. doi: 10.1016/j.bpc.2024.107233. [PMID: 38579435]
  • Yibao Wei, Junfeng Kang, Zhenyuan Ma, Taiyang Liao, Peng Wu, Peimin Wang, Zhengquan Huang. Protective effects of emodin on subchondral bone and articular cartilage in osteoporotic osteoarthritis rats: A preclinical study. Experimental gerontology. 2024 Jun; 190(?):112413. doi: 10.1016/j.exger.2024.112413. [PMID: 38570055]
  • Ting Han, Wenjuan Xu, Xuan Wang, Jiahui Gao, Shuyan Zhang, Linlin Yang, Min Wang, Chunshuai Li, Xiangri Li. Emodin-8-O-β-D-glucopyranoside-induced hepatotoxicity and gender differences in zebrafish as revealed by integration of metabolomics and transcriptomics. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155411. doi: 10.1016/j.phymed.2024.155411. [PMID: 38518638]
  • Yanxue Wang, Liang Li, Lingling Chen, Jinlei Xia, Tongli Wang, Lei Han, Liang Cao, Zhenzhong Wang, Wei Xiao, Shan Jiang. The Influence of Emodin Succinyl Ethyl Ester on Non-alcoholic Steatohepatitis Induced by a Diet High in Fructose, Cholesterol, and Fat in Mice. Biological & pharmaceutical bulletin. 2024 May; 47(5):978-987. doi: 10.1248/bpb.b23-00903. [PMID: 38631865]
  • Shimei Li, Songjiang Tang, Lina Dai, Zhonglu Jian, Xi Li. Emodin relieves morphine-stimulated BV2 microglial activation and inflammation through the TLR4/NF-κB/NLRP3 pathway. Neuroreport. 2024 May; 35(8):518-528. doi: 10.1097/wnr.0000000000002034. [PMID: 38597275]
  • Liuchang Feng, Zaoqiang Lin, Zeyong Tang, Lin Zhu, Shu Xu, Xi Tan, Xinyuan Wang, Jianling Mai, Qinxiang Tan. Emodin improves renal fibrosis in chronic kidney disease by regulating mitochondrial homeostasis through the mediation of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α). European journal of histochemistry : EJH. 2024 May; 68(2):. doi: 10.4081/ejh.2024.3917. [PMID: 38742403]
  • Jinsheng Gao, Yousong Li, Jiaohua Chen, Wen Feng, Jianchen Bu, Zixuan Lu, Jiandong Wang. Emodin ameliorates acute radiation proctitis in mice by regulating AKT/MAPK/NF-κB/VEGF pathways. International immunopharmacology. 2024 May; 132(?):111945. doi: 10.1016/j.intimp.2024.111945. [PMID: 38555816]
  • Tietao Di, Limin He, Qing Shi, Lu Chen, Lei Zhu, Sisi Zhao, Chunling Zhang. Emodin Blocks mPTP Opening and Improves LPS-Induced HMEC-1 Cell Injury by Upregulation of ATP5A1. Chemistry & biodiversity. 2024 May; 21(5):e202301916. doi: 10.1002/cbdv.202301916. [PMID: 38511277]
  • Shuxian Zhang, Xiaoying Wang, Xiaofei Wang, Xiaoxuan Fan, Keshuai Liu, Yuping Sa, Gidion Wilson, Xueqin Ma, Guoning Chen. Establishment and application of a screening method for α-glucosidase inhibitors based on dual sensing and affinity chromatography. Journal of chromatography. A. 2024 Apr; 1720(?):464822. doi: 10.1016/j.chroma.2024.464822. [PMID: 38502989]
  • Zheng Xueying, Guo Liang, Lai Siyi, L I Fengyue, Liang Mingli, Liu Wanting, Meng Chun, Liu Guanghui. Emodin suppresses alkali burn-induced corneal inflammation and neovascularization by the vascular endothelial growth factor receptor 2 signaling pathway. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Apr; 44(2):268-276. doi: 10.19852/j.cnki.jtcm.20240203.005. [PMID: 38504533]
  • Zhenxian Li, Haimei Zhu, Hao Liu, Dayue Liu, Jianhe Liu, Yi Zhang, Zhang Qin, Yijia Xu, Yuan Peng, Lihua Ruan, Jintao Li, Yao He, Bin Liu, Yun Long. Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin. Journal of nanobiotechnology. 2024 Mar; 22(1):129. doi: 10.1186/s12951-024-02389-5. [PMID: 38528554]
  • Hui Liu, Dan Guo, Jiao Wang, Wenxu Zhang, Zechao Zhu, Kunyuan Zhu, Shijun Bi, Pengyu Pan, Guobiao Liang. Aloe-emodin from Sanhua Decoction inhibits neuroinflammation by regulating microglia polarization after subarachnoid hemorrhage. Journal of ethnopharmacology. 2024 Mar; 322(?):117583. doi: 10.1016/j.jep.2023.117583. [PMID: 38122912]
  • Xin Dong, Ruijia Wen, Yuanyuan Xiong, Xiaotong Jia, Xiwen Zhang, Xin Li, Liangyou Zhang, Zhibin Li, Shu Zhang, Yanna Yu, Qiang Li, Xingbo Wu, Haitao Tu, Zixin Chen, Shaoxiang Xian, Lingjun Wang, Chao Wang, Lianqun Jia, Junyan Wang, Gangyi Chen. Emodin alleviates CRS4-induced mitochondrial damage via activation of the PGC1α signaling. Phytotherapy research : PTR. 2024 Mar; 38(3):1345-1357. doi: 10.1002/ptr.8091. [PMID: 38198804]
  • Na Zhang, Fengyi Lv, He Xiao, Bojiao Yi, Mingguo Shao, Hongbao Liang, Yonggang Wang, Na Guo, Jingchun Yao, Yongxia Guan, Guimin Zhang. Synergistic and attenuated effects and molecular biological mechanisms of Shouhui Tongbian capsule in the treatment of slow transit constipation based on UPLC-MS/MS, network pharmacology and animal experimental validation. Journal of pharmaceutical and biomedical analysis. 2024 Feb; 239(?):115846. doi: 10.1016/j.jpba.2023.115846. [PMID: 38039873]
  • Ruojun Du, Lichun Ye, Xinyan Chen, Yan Meng, Lei Zhou, Qiao Chen, Guohua Zheng, Junjie Hu, Zhaohua Shi. Screening of Key Components for Melanogenesis Inhibition of Polygonum cuspidatum Extract Based on the Spectrum-Effect Relationship and Molecular Docking. Molecules (Basel, Switzerland). 2024 Feb; 29(4):. doi: 10.3390/molecules29040857. [PMID: 38398609]
  • L I Xiuyan, Luo Yuting, Wang Jinhui, D U Zhimin. Formulation, characterization and and evaluation of aloe-emodin-loaded solid dispersions for dissolution enhancement. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Feb; 44(1):54-62. doi: 10.19852/j.cnki.jtcm.20231110.002. [PMID: 38213239]
  • Lixin Du, Huiling Lu, Yifei Xiao, Zhihua Guo, Ya Li. Prediction and analysis of quality markers for Chuantieling gel patches based on HPLC fingerprinting and network pharmacology. Biomedical chromatography : BMC. 2024 Feb; 38(2):e5773. doi: 10.1002/bmc.5773. [PMID: 38048642]
  • Jiali Wu, Yaokun Pang, Dan Liu, Jianxia Sun, Weibin Bai. Photodynamic Inactivation of Staphylococcus aureus Using Aloe-emodin as Photosensitizer. Food research international (Ottawa, Ont.). 2024 Feb; 178(?):113959. doi: 10.1016/j.foodres.2024.113959. [PMID: 38309912]
  • Lifang Wang, Haijao Wang, Jingjing Niu, Honggang Chen, Meng Wang, Zhigang Yang, Shaohua Wang, Xiuxia Sun, Yanbin Shi. Cholesterol-lowering effects of rhubarb free anthraquinones and their mechanism of action. European journal of pharmacology. 2024 Jan; ?(?):176348. doi: 10.1016/j.ejphar.2024.176348. [PMID: 38286356]
  • Changyudong Huang, Yiqiong Zhang, Yongjie Xu, Sijia Wei, Tingting Yang, Shuang Wang, Chengcheng Li, Hairong Lin, Xing Li, Shuyun Zhao, Liying Zhu, Wei Pan. Prepared radix polygoni multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition. Aging. 2024 Jan; 16(?):. doi: 10.18632/aging.205485. [PMID: 38284886]
  • Young-Seon Kim, Ji-Hye Han, Chang-Hoon Lim, Xue-Quan Fang, Hyeock-Soon Jang, Sang-Yun Lee, Woo-Jong Yim, Ji-Hong Lim. Effects of Fermented Polygonum cuspidatum on the Skeletal Muscle Functions. Nutrients. 2024 Jan; 16(2):. doi: 10.3390/nu16020305. [PMID: 38276543]
  • Yan Ye, Wenzhen Zhong, Ruifeng Luo, Hongzhi Wen, Ziyang Ma, Shanshan Qi, Xiaoqin Han, Wenbiao Nie, Degui Chang, Runchun Xu, Naijing Ye, Fei Gao, Peihai Zhang. Thermosensitive hydrogel with emodin-loaded triple-targeted nanoparticles for a rectal drug delivery system in the treatment of chronic non-bacterial prostatitis. Journal of nanobiotechnology. 2024 Jan; 22(1):33. doi: 10.1186/s12951-023-02282-7. [PMID: 38238760]
  • Qiang Huang, Meiling Fan, Fenglan Ji, Yuqi Wang, Hongyue Ding, Jie Xu, Xin Wang, Bo Liu, Bei Wang, Xinmiao Yu, Zhidong Qiu, Fan Yao. The safety evaluation of Shenze Shugan capsule and mechanism of apoptosis induced by five potentially nephrotoxic components. Journal of ethnopharmacology. 2024 Jan; 324(?):117777. doi: 10.1016/j.jep.2024.117777. [PMID: 38219879]
  • Fang Zhang, Rui Wu, Yanfang Liu, Shu Dai, Xinyan Xue, Xiaohong Gong, Yunxia Li. Comparative Pharmacokinetic Study of Rhubarb Anthraquinones in Normal and Nonalcoholic Fatty Liver Disease Rats. European journal of drug metabolism and pharmacokinetics. 2024 Jan; 49(1):111-121. doi: 10.1007/s13318-023-00875-z. [PMID: 38112917]
  • Mohamed Mendili, Ayda Khadhri, Francesca Sabatini, Ilaria Degano, Samira Aschi-Smiti. Parietin, the Vibrant Natural Dye in Xanthoria parietina. Chemistry & biodiversity. 2024 Jan; 21(1):e202301357. doi: 10.1002/cbdv.202301357. [PMID: 38072912]
  • Shuxiang Zhang, Zhongdi Huang, Huanhuan Xu, Qihua Liu, Zhou Jiang, Caiping Yin, Guomin Han, Wei Zhang, Yinglao Zhang. Biological control of wheat powdery mildew disease by the termite-associated fungus Aspergillus chevalieri BYST01 and potential role of secondary metabolites. Pest management science. 2023 Dec; ?(?):. doi: 10.1002/ps.7938. [PMID: 38105413]
  • Yanli Wang, Siwei Zhong, Ke Yang, Ruifeng Luo, Linxin Dai, Wenzhen Zhong, Yan Ye, Chaomei Fu, Dasheng Lin, Nan Li, Jianping Chen, Chuan Zheng, Shu Fu, Fei Gao. β-1,3-d-glucan particles-based "nest" protected co-loaded Rhein and Emodin regulates microbiota and intestinal immunity for ulcerative colitis treatment. International journal of biological macromolecules. 2023 Dec; 260(Pt 2):128818. doi: 10.1016/j.ijbiomac.2023.128818. [PMID: 38103669]
  • Si Liu, Xiao-Hua Luo, Yu-Feng Liu, Christos C Zouboulis, Ge Shi. Emodin exhibits anti-acne potential by inhibiting cell growth, lipogenesis, and inflammation in human SZ95 sebocytes. Scientific reports. 2023 12; 13(1):21576. doi: 10.1038/s41598-023-48709-x. [PMID: 38062074]
  • Chen Wang, Lulu Wu, Runjin Zhou, Cuiwen Song, Peng Chen, Shiying Huang, Ahsan Ali Khan, Deng Lu, Yong Hu, Lukui Chen. Integration of microbiota and metabolomics reveals the analgesic mechanisms of emodin against neuropathic pain. International immunopharmacology. 2023 Dec; 125(Pt A):111170. doi: 10.1016/j.intimp.2023.111170. [PMID: 37944218]
  • Lin Zhou, Xiaohui Wang, Jinlan Xia, Liyuan Zhang, Lianping Xue, Qingquan Jia, Zhihui Fu, Zhi Sun. Pharmacokinetic-pharmacodynamic modeling of the active components of Shenkang injection in rats with chronic renal failure and its protective effect on damaged renal cells. Biopharmaceutics & drug disposition. 2023 Dec; 44(6):406-419. doi: 10.1002/bdd.2377. [PMID: 37679901]
  • Jie Tang, Lixiang Wang, Mengge Shi, Shuaixia Feng, Tong Zhang, Han Han. Study on the mechanism of Shuganzhi Tablet against nonalcoholic fatty liver disease and lipid regulation effects of its main substances in vitro. Journal of ethnopharmacology. 2023 Nov; 316(?):116780. doi: 10.1016/j.jep.2023.116780. [PMID: 37311504]
  • Ruland Tchuinkeu Nguengang, Billy Toussie Tchegnitegni, Joel Eddy Terence Ateba, Georges Bellier Tabekoueng, Angelbert Fusi Awantu, Jean Jules Kezetas Bankeu, Jean Rodolphe Chouna, Celine Nguefeu Nkenfou, Norbert Sewald, Bruno Ndjakou Lenta. Antibacterial constituents of Rumex nepalensis spreng and its emodin derivatives. Natural product research. 2023 Nov; 37(23):3935-3946. doi: 10.1080/14786419.2022.2162894. [PMID: 36584290]
  • Hao Chai, Fangfang Xu, Jixia Wang, Yuxin Zhang, Xiaomin Xie, Han Zhou, Yanfang Liu, Xinmiao Liang, Aoxue Wang. Profiling CCR3 target pathways for discovering novel antagonists from natural products using label-free cell phenotypic assays. Chemico-biological interactions. 2023 Nov; 385(?):110732. doi: 10.1016/j.cbi.2023.110732. [PMID: 37788752]
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  • Maliha Fatima, Arshia Amin, Metab Alharbi, Sundas Ishtiaq, Wasim Sajjad, Faisal Ahmad, Sajjad Ahmad, Faisal Hanif, Muhammad Faheem, Atif Ali Khan Khalil. Quorum Quenchers from Reynoutria japonica in the Battle against Methicillin-Resistant Staphylococcus aureus (MRSA). Molecules (Basel, Switzerland). 2023 Mar; 28(6):. doi: 10.3390/molecules28062635. [PMID: 36985607]
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  • Maryam Malmir, Katelene Lima, Sérgio Póvoas Camões, Vera Manageiro, Maria Paula Duarte, Joana Paiva Miranda, Rita Serrano, Isabel Moreira da Silva, Beatriz Silva Lima, Manuela Caniça, Olga Silva. Identification of Marker Compounds and In Vitro Toxicity Evaluation of Two Portuguese Asphodelus Leaf Extracts. Molecules (Basel, Switzerland). 2023 Mar; 28(5):. doi: 10.3390/molecules28052372. [PMID: 36903618]
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  • Ko-Hsuan Chen, Florencia Marcón, Jennifer Duringer, Ann Blount, Cheryl Mackowiak, Hui-Ling Liao. Leaf Mycobiome and Mycotoxin Profile of Warm-Season Grasses Structured by Plant Species, Geography, and Apparent Black-Stroma Fungal Structure. Applied and environmental microbiology. 2022 11; 88(21):e0094222. doi: 10.1128/aem.00942-22. [PMID: 36226941]
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  • Bo Yuan, Nancy P Keller, Berl R Oakley, Jason E Stajich, Clay C C Wang. Manipulation of the Global Regulator mcrA Upregulates Secondary Metabolite Production in Aspergillus wentii Using CRISPR-Cas9 with In Vitro Assembled Ribonucleoproteins. ACS chemical biology. 2022 10; 17(10):2828-2835. doi: 10.1021/acschembio.2c00456. [PMID: 36197945]
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  • Yan Zhang, Lijun Wang, Liushen Lu, Meiling Liu, Zhenbo Yuan, Lifeng Yang, Changmei Liu, Shuping Huang, Yijian Rao. Highly efficient decontamination of tetracycline and pathogen by a natural product-derived Emodin/HAp photocatalyst. Chemosphere. 2022 Oct; 305(?):135401. doi: 10.1016/j.chemosphere.2022.135401. [PMID: 35738405]