Emodin (BioDeep_00000398712)

natural product PANOMIX_OTCML-2023

代谢物信息卡片

9,10-Anthracenedione, 1,3,8-trihydroxy-6-methyl- (9CI)

化学式: C15H10O5 (270.052821)
中文名称: 大黄素
谱图信息: 最多检出来源 Viridiplantae(plant) 1.2%

分子结构信息

SMILES: CC1=CC(=C2C(=C1)C(=O)C3=CC(=CC(=C3C2=O)O)O)O
InChI: InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3

描述信息

C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
D005765 - Gastrointestinal Agents > D002400 - Cathartics
CONFIDENCE isolated standard
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.288
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.291
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.286
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.293
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].

同义名列表

80 个代谢物同义名

9,10-Anthracenedione, 1,3,8-trihydroxy-6-methyl- (9CI); 9,10-Anthracenedione, 1,3,8-trihydroxy-6-methyl-; 1,3,8-trihydroxy-6-methyl-anthracene-9,10-dione; Anthraquinone, 1,3,8-trihydroxy-6-methyl- (8CI); 1,3,8-trihydroxy-6-methylanthracene-9,10-dione; Emodin; 6-Methyl-1,3,8-trihydroxyanthraquinone; 6-Methyl-1,3,8-trihydroxy-9,10-anthracenedione; 1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione; 1,3,8-Trihydroxy-6-methyl-9,10-anthraquinone; 6-Methyl-1,3,8-tri- hydroxy- anthra- quinone; 1,3,8-Tri- hydroxy-6-methyl- anthra- quinone; 1,3,8-Trihydroxy-6-methylanthra-9,10-quinone; 4-08-00-03575 (Beilstein Handbook Reference); Anthraquinone, 6-methyl-1,3,8-trihydroxy-; Anthraquinone, 1,3,8-trihydroxy-6-methyl-; 3-Methyl-1,6,8-trihydroxyanthraquinone; 6-Methyl-1,3,8-trihydroxyanthraquinone; 1,3,8-Trihydroxy-6-methylanthraquinone; 4,5,7-Trihydroxy-2-methylanthraquinone; C.I. Natural Yellow 14; Persian Berry Lake; Spectrum2_000895; EINECS 208-258-8; Spectrum5_000614; Spectrum3_000742; Spectrum4_001757; Spectrum_001954; NCGC00091540-05; NCGC00015420-02; SpecPlus_000332; Frangula emodin; NCGC00091540-01; Frangula-emodin; NCGC00015420-01; NCIMech_000049; BSPBio_002324; DivK1c_006428; KBioSS_002508; Lopac0_000552; MEGxp0_000460; KBioGR_002234; MLS001066370; ZINC03824868; Rheum emodin; KBio1_001372; SMR000326798; KBio3_001544; KBio2_007636; KBio2_005068; NCI60_003906; LMPK02000037; KBio2_002500; ACon1_001939; Lopac-E-7881; SPBio_000710; SMP2_000211; CHEBI:42223; BRN 1888141; 45170_FLUKA; AIDS-001392; E7881_SIGMA; NSC 622947; NSC 408120; AIDS001392; EU-0100552; Schuttgelb; CCRIS 3528; C.I. 75440; HSDB 7093; NSC408120; NSC622947; AI3-38286; TNP00318; 518-82-1; ST055355; Emodin; C10343; K00056; Emodol; EMO

数据库引用编号

47 个数据库交叉引用编号

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

343 个相关的物种来源信息

33090 猕猴桃根: -
33090 苎麻根: -
33090 牵牛子: -
33090 石菖蒲: -
33090 淫羊藿: -
33090 鸡血藤: -
33090 番泻叶: -
33090 金荞麦: -
53851 决明子: -
33090 鸡骨草: -
33090 地骨皮: -
33090 土贝母: -
33090 大血藤: -
33090 黄药子: -
33090 延胡索: -
33090 板蓝根: -
33090 枳椇子: -
33090 高良姜: -
33090 鼠曲草: -
33090 山豆根: -
33090 苍耳子: -
33090 白蔹: -
33090 虎杖: -
33090 百合: -
33090 薄荷: -
33090 蒺藜: -
33090 紫菀: -
33090 大黄: -
33090 泽泻: -
33090 瞿麦: -
291102 Rumex cyprius:
317192 Rumex vesicarius: 10.1016/0305-1978(93)90049-W
1786036 Rumex pictus: 10.1016/0305-1978(93)90049-W
291098 Rumex pulcher:
1006352 Rumex dentatus: 10.1016/0305-1978(93)90049-W
126820 Senna occidentalis:
508996 Cassia javanica:
346985 Senna obtusifolia:
53923 Senna alata:
1288009 Senna macranthera var. micans:
362788 Senna tora:
948718 Senna sophera:
174651 Rumex japonicus:
110160 Guanomyces polythrix:
1813084 Rhamnus libanotica: 10.1016/0031-9422(90)85060-S
1813207 Rhamnus nakaharae: 10.1021/NP50085A021
137225 Rheum sublanceolatum: 10.1055/S-2008-1074562
137223 Rheum pumilum:
2743666 Rheum racemiferum:
694413 Rheum delavayi:
137219 Rheum nanum: 10.1055/S-2008-1074562
137221 Rheum palmatum:
1389495 Aloe castellorum: 10.1080/14786410802242851
1786032 Rumex chalepensis:
282553 Hypericum sampsonii:
2704497 Vismia laurentii:
62330 Fagopyrum tataricum: 10.1111/J.1365-2621.1953.TB17705.X
72401 Senna didymobotrya:
53852 Cassia fistula:
346999 Senna siamea:
54800 Larix kaempferi: 10.5246/JCPS.2012.05.057
3355 Pseudolarix amabilis: 10.5246/JCPS.2012.05.057
3610 Rhamnus cathartica:
161756 Isatis tinctoria: 10.1016/S0040-4020(97)00846-6
453927 Juniperus formosana:
992784 Senna petersiana: 10.1016/S0367-326X(00)00155-6
346959 Senna corymbosa: 10.1016/0031-9422(92)80483-U
162908 Senna lindheimeriana: 10.1016/0031-9422(92)80483-U
262734 Ligularia pleurocaulis: 10.1007/S10600-011-9810-Y
46087 Rheum rhaponticum:
3621 Rheum rhabarbarum:
205071 Rheum tataricum: 10.1016/0378-8741(84)90016-3
137217 Rheum hotaoense: 10.1016/0378-8741(84)90016-3
240183 Rheum kialense: 10.1016/0378-8741(84)90016-3
137216 Rheum compactum: 10.1016/0378-8741(84)90016-3
137227 Rheum undulatum:
137220 Rheum officinale:
240184 Rheum spiciforme: 10.1016/0378-8741(84)90016-3
137224 Rheum reticulatum: 10.1016/0378-8741(84)90016-3
137697 Rheum nobile: 10.1016/0378-8741(84)90016-3
137218 Rheum likiangense: 10.1016/0378-8741(84)90016-3
240182 Rheum franzenbachii:
574896 Rheum altaicum: 10.1016/0378-8741(84)90016-3
694412 Rheum acuminatum: 10.1016/0378-8741(84)90016-3
137226 Rheum tanguticum:
284363 Rheum australe:
137228 Rheum wittrockii: 10.1016/0378-8741(84)90016-3
284362 Rheum alexandrae: 10.1016/0378-8741(84)90016-3
346998 Senna septemtrionalis:
948713 Senna auriculata:
72402 Senna alexandrina:
180472 Asahinea chrysantha: 10.1007/BF00638766
5544 Trichoderma harzianum: 10.1021/JF901405C
5340 Agaricus:
241057 Neurospora micropertusa:
35608 Artemisia annua: 10.1016/S0278-6915(99)00027-7
39414 Plantago lanceolata: 10.1016/S0278-6915(99)00027-7
3888 Pisum sativum: 10.1016/S0278-6915(99)00027-7
4236 Lactuca sativa: 10.1016/S0278-6915(99)00027-7
3617 Fagopyrum esculentum: 10.1016/S0278-6915(99)00027-7
101996 Plantago coronopus: 10.1016/S0278-6915(99)00027-7
29760 Vitis vinifera: 10.1016/S0278-6915(99)00027-7
52152 Elymus repens: 10.1016/S0278-6915(99)00027-7
13427 Cichorium intybus: 10.1016/S0278-6915(99)00027-7
262086 Heterodermia obscurata: 10.1016/0031-9422(95)00407-X
203386 Nephroma laevigatum:
5547 Trichoderma viride: 10.1139/V67-020
1813066 Rhamnus procumbens: 10.1002/PTR.2650020109
210369 Tribulus terrestris: 10.1055/S-0036-1578747
1129486 Picramnia antidesma:
2686320 Picramnia teapensis:
28564 Talaromyces stipitatus: 10.1007/BF01926640
2587388 Canariomyces subthermophilus: 10.1021/NP9002977
46901 Persicaria hydropiper: 10.1016/S0024-3205(97)00937-5
76025 Fallopia multiflora:
76036 Fallopia sachalinensis: 10.1007/BF02751107
280022 Rhamnus prinoides:
33178 Aspergillus terreus:
41288 Aspergillus aureoterreus: 10.1248/CPB.31.4543
948716 Chamaecrista nigricans: 10.1080/13880200490902545
108868 Ventilago leiocarpa:
1390085 Ventilago denticulata:
273505 Rumex abyssinicus:
174652 Rumex nepalensis:
174649 Rumex crispus:
280025 Rhamnus saxatilis: 10.1016/S0305-1978(00)00025-9
1465361 Rhamnus sphaerosperma: 10.1016/S0305-1978(00)00025-9
25641 Aloe: 10.1002/JPS.2600580211
2686326 Picramnia hirsuta:
5066 Aspergillus wentii: 10.1128/AEM.02187-09
384659 Achyranthes bidentata: 10.17660/ACTAHORTIC.1996.426.7
59982 Myrsine africana: 10.1021/NP50063A035
271752 Ploiarium alternifolium: 10.1016/S0040-4039(00)94620-3
371130 Microdiplodia: 10.1021/NP100730B
105902 Rhamnus davurica: 10.1021/NP010030V
278676 Rumex cristatus: 10.1042/BJ0980112
749552 Boeremia foveata: 10.1042/BJ0980112
798162 Setophoma terrestris: 10.7164/ANTIBIOTICS.32.1256
1813065 Rhamnus pallasii: 10.1007/BF00574350
308637 Eriococcus coriaceus: 10.1039/C29700001577
40695 Trichoderma polysporum: 10.1016/S0031-9422(00)81684-2
47341 Dermocybe: 10.1071/C97155
1819798 Rhamnus wightii: 10.1016/0031-9422(91)83502-C
1813053 Rhamnus formosana:
424903 Osmanthus armatus: 10.1080/14786410802689713
41413 Aspergillus glaucus: 10.1021/NP800303T
265493 Catalpa longissima: 10.1055/S-0028-1097458
54806 Saururus chinensis: 10.3987/COM-95-7370
345802 Ventilago madraspatana: 10.1111/J.2042-7158.2010.01151.X
78068 Flavocetraria cucullata: 10.1016/0031-9422(82)80041-1
1526916 Chamaecrista pumila:
34199 Aloe vera: 10.1016/S0031-9422(97)00107-6
1813059 Rhamnus kurdica: 10.3109/13880209209053982
1778787 Rhamnus punctata: 10.3109/13880209209053982
396024 Aspergillus ruber: 10.1002/HLCA.201100255
742017 Cortinarius basirubescens: 10.1016/J.PHYTOCHEM.2010.03.016
999598 Vismia guianensis: 10.1021/NP990226J
69784 Penicillium restrictum: 10.1021/NP5000704
2704500 Psorospermum tenuifolium: 10.1016/S0031-9422(00)83889-3
1387318 Eriocaulon buergerianum: 10.1016/J.PHYTOCHEM.2007.11.014
304759 Cortinarius sanguineus:
39317 Hamigera avellanea: 10.1016/J.TET.2008.09.077
38448 Monilinia fructicola: 10.1271/BBB1961.55.95
71662 Monodictys: 10.1248/CPB.55.1097
198761 Cratoxylum formosum: 10.1016/J.TET.2006.06.003
5073 Penicillium: 10.1002/DDR.430360106
117978 Dendrobium thyrsiflorum: 10.1016/J.PHYTOCHEM.2005.04.001
1351827 Rumex alpinus: 10.1007/BF00596663
1630247 Rhamnus triquetra: 10.1016/0031-9422(73)80418-2
242528 Rumex scutatus: 10.1515/ZNC-1997-9-1014
459154 Simaba orinocensis: 10.1055/S-2007-969512
61450 Rumex acetosella: 10.15281/JPLANTRES1887.39.468_353
41241 Rumex acetosa:
137229 Rumex patientia: 10.1016/S0031-9422(01)00337-5
1225674 Derris cuneifolia:
3620 Rheum:
158314 Polyporus umbellatus: 10.3184/030823409X12562954717147
139234 Pyrenophora catenaria: 10.1016/S0031-9422(00)91370-0
1131644 Talaromyces brunneus: 10.1248/CPB.11.402
3618 Rumex: 10.1016/J.BMCL.2013.04.059
346948 Senna artemisioides: 10.1080/10286020.2010.534081
291102 Rumex cyprius:
317192 Rumex vesicarius: 10.1016/0305-1978(93)90049-W
1786036 Rumex pictus: 10.1016/0305-1978(93)90049-W
291098 Rumex pulcher:
1006352 Rumex dentatus: 10.1016/0305-1978(93)90049-W
126820 Senna occidentalis:
508996 Cassia javanica:
346985 Senna obtusifolia:
53923 Senna alata:
1288009 Senna macranthera var. micans:
362788 Senna tora:
948718 Senna sophera:
174651 Rumex japonicus:
110160 Guanomyces polythrix:
1813084 Rhamnus libanotica: 10.1016/0031-9422(90)85060-S
1813207 Rhamnus nakaharae: 10.1021/NP50085A021
137225 Rheum sublanceolatum: 10.1055/S-2008-1074562
137223 Rheum pumilum:
2743666 Rheum racemiferum:
694413 Rheum delavayi:
137219 Rheum nanum: 10.1055/S-2008-1074562
137221 Rheum palmatum:
1389495 Aloe castellorum: 10.1080/14786410802242851
1786032 Rumex chalepensis:
282553 Hypericum sampsonii:
2704497 Vismia laurentii:
62330 Fagopyrum tataricum: 10.1111/J.1365-2621.1953.TB17705.X
72401 Senna didymobotrya:
53852 Cassia fistula:
346999 Senna siamea:
54800 Larix kaempferi: 10.5246/JCPS.2012.05.057
3355 Pseudolarix amabilis: 10.5246/JCPS.2012.05.057
3610 Rhamnus cathartica:
161756 Isatis tinctoria: 10.1016/S0040-4020(97)00846-6
453927 Juniperus formosana:
992784 Senna petersiana: 10.1016/S0367-326X(00)00155-6
346959 Senna corymbosa: 10.1016/0031-9422(92)80483-U
162908 Senna lindheimeriana: 10.1016/0031-9422(92)80483-U
262734 Ligularia pleurocaulis: 10.1007/S10600-011-9810-Y
46087 Rheum rhaponticum:
3621 Rheum rhabarbarum:
205071 Rheum tataricum: 10.1016/0378-8741(84)90016-3
137217 Rheum hotaoense: 10.1016/0378-8741(84)90016-3
240183 Rheum kialense: 10.1016/0378-8741(84)90016-3
137216 Rheum compactum: 10.1016/0378-8741(84)90016-3
137227 Rheum undulatum:
137220 Rheum officinale:
240184 Rheum spiciforme: 10.1016/0378-8741(84)90016-3
137224 Rheum reticulatum: 10.1016/0378-8741(84)90016-3
137697 Rheum nobile: 10.1016/0378-8741(84)90016-3
137218 Rheum likiangense: 10.1016/0378-8741(84)90016-3
240182 Rheum franzenbachii:
574896 Rheum altaicum: 10.1016/0378-8741(84)90016-3
694412 Rheum acuminatum: 10.1016/0378-8741(84)90016-3
137226 Rheum tanguticum:
284363 Rheum australe:
137228 Rheum wittrockii: 10.1016/0378-8741(84)90016-3
284362 Rheum alexandrae: 10.1016/0378-8741(84)90016-3
346998 Senna septemtrionalis:
948713 Senna auriculata:
72402 Senna alexandrina:
180472 Asahinea chrysantha: 10.1007/BF00638766
5544 Trichoderma harzianum: 10.1021/JF901405C
5340 Agaricus:
241057 Neurospora micropertusa:
35608 Artemisia annua: 10.1016/S0278-6915(99)00027-7
39414 Plantago lanceolata: 10.1016/S0278-6915(99)00027-7
3888 Pisum sativum: 10.1016/S0278-6915(99)00027-7
4236 Lactuca sativa: 10.1016/S0278-6915(99)00027-7
3617 Fagopyrum esculentum: 10.1016/S0278-6915(99)00027-7
101996 Plantago coronopus: 10.1016/S0278-6915(99)00027-7
29760 Vitis vinifera: 10.1016/S0278-6915(99)00027-7
52152 Elymus repens: 10.1016/S0278-6915(99)00027-7
13427 Cichorium intybus: 10.1016/S0278-6915(99)00027-7
262086 Heterodermia obscurata: 10.1016/0031-9422(95)00407-X
203386 Nephroma laevigatum:
5547 Trichoderma viride: 10.1139/V67-020
1813066 Rhamnus procumbens: 10.1002/PTR.2650020109
210369 Tribulus terrestris: 10.1055/S-0036-1578747
1129486 Picramnia antidesma:
2686320 Picramnia teapensis:
28564 Talaromyces stipitatus: 10.1007/BF01926640
2587388 Canariomyces subthermophilus: 10.1021/NP9002977
46901 Persicaria hydropiper: 10.1016/S0024-3205(97)00937-5
76025 Fallopia multiflora:
76036 Fallopia sachalinensis: 10.1007/BF02751107
280022 Rhamnus prinoides:
33178 Aspergillus terreus:
41288 Aspergillus aureoterreus: 10.1248/CPB.31.4543
948716 Chamaecrista nigricans: 10.1080/13880200490902545
108868 Ventilago leiocarpa:
1390085 Ventilago denticulata:
273505 Rumex abyssinicus:
174652 Rumex nepalensis:
174649 Rumex crispus:
280025 Rhamnus saxatilis: 10.1016/S0305-1978(00)00025-9
1465361 Rhamnus sphaerosperma: 10.1016/S0305-1978(00)00025-9
25641 Aloe: 10.1002/JPS.2600580211
2686326 Picramnia hirsuta:
5066 Aspergillus wentii: 10.1128/AEM.02187-09
384659 Achyranthes bidentata: 10.17660/ACTAHORTIC.1996.426.7
59982 Myrsine africana: 10.1021/NP50063A035
271752 Ploiarium alternifolium: 10.1016/S0040-4039(00)94620-3
371130 Microdiplodia: 10.1021/NP100730B
105902 Rhamnus davurica: 10.1021/NP010030V
278676 Rumex cristatus: 10.1042/BJ0980112
749552 Boeremia foveata: 10.1042/BJ0980112
798162 Setophoma terrestris: 10.7164/ANTIBIOTICS.32.1256
1813065 Rhamnus pallasii: 10.1007/BF00574350
308637 Eriococcus coriaceus: 10.1039/C29700001577
40695 Trichoderma polysporum: 10.1016/S0031-9422(00)81684-2
47341 Dermocybe: 10.1071/C97155
1819798 Rhamnus wightii: 10.1016/0031-9422(91)83502-C
1813053 Rhamnus formosana:
424903 Osmanthus armatus: 10.1080/14786410802689713
41413 Aspergillus glaucus: 10.1021/NP800303T
265493 Catalpa longissima: 10.1055/S-0028-1097458
54806 Saururus chinensis: 10.3987/COM-95-7370
345802 Ventilago madraspatana: 10.1111/J.2042-7158.2010.01151.X
78068 Flavocetraria cucullata: 10.1016/0031-9422(82)80041-1
1526916 Chamaecrista pumila:
34199 Aloe vera: 10.1016/S0031-9422(97)00107-6
1813059 Rhamnus kurdica: 10.3109/13880209209053982
1778787 Rhamnus punctata: 10.3109/13880209209053982
396024 Aspergillus ruber: 10.1002/HLCA.201100255
742017 Cortinarius basirubescens: 10.1016/J.PHYTOCHEM.2010.03.016
999598 Vismia guianensis: 10.1021/NP990226J
69784 Penicillium restrictum: 10.1021/NP5000704
2704500 Psorospermum tenuifolium: 10.1016/S0031-9422(00)83889-3
1387318 Eriocaulon buergerianum: 10.1016/J.PHYTOCHEM.2007.11.014
304759 Cortinarius sanguineus:
39317 Hamigera avellanea: 10.1016/J.TET.2008.09.077
38448 Monilinia fructicola: 10.1271/BBB1961.55.95
71662 Monodictys: 10.1248/CPB.55.1097
198761 Cratoxylum formosum: 10.1016/J.TET.2006.06.003
5073 Penicillium: 10.1002/DDR.430360106
117978 Dendrobium thyrsiflorum: 10.1016/J.PHYTOCHEM.2005.04.001
1351827 Rumex alpinus: 10.1007/BF00596663
1630247 Rhamnus triquetra: 10.1016/0031-9422(73)80418-2
242528 Rumex scutatus: 10.1515/ZNC-1997-9-1014
459154 Simaba orinocensis: 10.1055/S-2007-969512
61450 Rumex acetosella: 10.15281/JPLANTRES1887.39.468_353
41241 Rumex acetosa:
137229 Rumex patientia: 10.1016/S0031-9422(01)00337-5
1225674 Derris cuneifolia:
3620 Rheum:
158314 Polyporus umbellatus: 10.3184/030823409X12562954717147
139234 Pyrenophora catenaria: 10.1016/S0031-9422(00)91370-0
1131644 Talaromyces brunneus: 10.1248/CPB.11.402
3618 Rumex: 10.1016/J.BMCL.2013.04.059
346948 Senna artemisioides: 10.1080/10286020.2010.534081
714442 Ampelopsis Japonica: -
455371 Spatholobus Suberectus Dunn: -
3625 Actinidia Chinensis Planch: -
79002 Lilium lancifolium Thunb.: -
82312 Lilium brownii F.E.Brown var.viridulum Baker: -
82327 Lilium Pumilum DC.: -
137221 Rheum palmatum L.: -
137226 Rheum tanguticum Maxim. ex Balf.: -
137220 Rheum officinale Baill.: -
83819 Polygonum cuspidatum Sieb. et Zucc.: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Wei Huang, Peiting Zhou, Xinyun Zou, Yunchuan Liu, Longfu Zhou, Yaolei Zhang. Emodin ameliorates myocardial fibrosis in mice by inactivating the ROS/PI3K/Akt/mTOR axis. Clinical and experimental hypertension (New York, N.Y. : 1993). 2024 Dec; 46(1):2326022. doi: 10.1080/10641963.2024.2326022. [PMID: 38507311]
Lu Liu, Sen Sun, Xiaohua Li. Physcion inhibition of CYP2C9, 2D6 and 3A4 in human liver microsomes. Pharmaceutical biology. 2024 Dec; 62(1):207-213. doi: 10.1080/13880209.2024.2314089. [PMID: 38353248]
Huang-Fei Jin, Qian-Xue Shen, Ying Shi, Fang-Ming Liu, Bin Wang, Jun Cao, Li-Hong Ye. Magnetic-stirring-enhanced mechanical amorphous dispersion extraction for the hydrophobic phytochemical constituents using an aqueous solution from a medicinal plant. Journal of pharmaceutical and biomedical analysis. 2024 Aug; 245(?):116191. doi: 10.1016/j.jpba.2024.116191. [PMID: 38728950]
Antonio R da Cunha, Evandro L Duarte, Gabriel S Vignoli Muniz, Kaline Coutinho, M Teresa Lamy. New insights into the interaction of emodin with lipid membranes. Biophysical chemistry. 2024 Jun; 309(?):107233. doi: 10.1016/j.bpc.2024.107233. [PMID: 38579435]
Yibao Wei, Junfeng Kang, Zhenyuan Ma, Taiyang Liao, Peng Wu, Peimin Wang, Zhengquan Huang. Protective effects of emodin on subchondral bone and articular cartilage in osteoporotic osteoarthritis rats: A preclinical study. Experimental gerontology. 2024 Jun; 190(?):112413. doi: 10.1016/j.exger.2024.112413. [PMID: 38570055]
Ting Han, Wenjuan Xu, Xuan Wang, Jiahui Gao, Shuyan Zhang, Linlin Yang, Min Wang, Chunshuai Li, Xiangri Li. Emodin-8-O-β-D-glucopyranoside-induced hepatotoxicity and gender differences in zebrafish as revealed by integration of metabolomics and transcriptomics. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155411. doi: 10.1016/j.phymed.2024.155411. [PMID: 38518638]
Yanxue Wang, Liang Li, Lingling Chen, Jinlei Xia, Tongli Wang, Lei Han, Liang Cao, Zhenzhong Wang, Wei Xiao, Shan Jiang. The Influence of Emodin Succinyl Ethyl Ester on Non-alcoholic Steatohepatitis Induced by a Diet High in Fructose, Cholesterol, and Fat in Mice. Biological & pharmaceutical bulletin. 2024 May; 47(5):978-987. doi: 10.1248/bpb.b23-00903. [PMID: 38631865]
Shimei Li, Songjiang Tang, Lina Dai, Zhonglu Jian, Xi Li. Emodin relieves morphine-stimulated BV2 microglial activation and inflammation through the TLR4/NF-κB/NLRP3 pathway. Neuroreport. 2024 May; 35(8):518-528. doi: 10.1097/wnr.0000000000002034. [PMID: 38597275]
Liuchang Feng, Zaoqiang Lin, Zeyong Tang, Lin Zhu, Shu Xu, Xi Tan, Xinyuan Wang, Jianling Mai, Qinxiang Tan. Emodin improves renal fibrosis in chronic kidney disease by regulating mitochondrial homeostasis through the mediation of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α). European journal of histochemistry : EJH. 2024 May; 68(2):. doi: 10.4081/ejh.2024.3917. [PMID: 38742403]
Jinsheng Gao, Yousong Li, Jiaohua Chen, Wen Feng, Jianchen Bu, Zixuan Lu, Jiandong Wang. Emodin ameliorates acute radiation proctitis in mice by regulating AKT/MAPK/NF-κB/VEGF pathways. International immunopharmacology. 2024 May; 132(?):111945. doi: 10.1016/j.intimp.2024.111945. [PMID: 38555816]
Tietao Di, Limin He, Qing Shi, Lu Chen, Lei Zhu, Sisi Zhao, Chunling Zhang. Emodin Blocks mPTP Opening and Improves LPS-Induced HMEC-1 Cell Injury by Upregulation of ATP5A1. Chemistry & biodiversity. 2024 May; 21(5):e202301916. doi: 10.1002/cbdv.202301916. [PMID: 38511277]
Shuxian Zhang, Xiaoying Wang, Xiaofei Wang, Xiaoxuan Fan, Keshuai Liu, Yuping Sa, Gidion Wilson, Xueqin Ma, Guoning Chen. Establishment and application of a screening method for α-glucosidase inhibitors based on dual sensing and affinity chromatography. Journal of chromatography. A. 2024 Apr; 1720(?):464822. doi: 10.1016/j.chroma.2024.464822. [PMID: 38502989]
Zheng Xueying, Guo Liang, Lai Siyi, L I Fengyue, Liang Mingli, Liu Wanting, Meng Chun, Liu Guanghui. Emodin suppresses alkali burn-induced corneal inflammation and neovascularization by the vascular endothelial growth factor receptor 2 signaling pathway. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Apr; 44(2):268-276. doi: 10.19852/j.cnki.jtcm.20240203.005. [PMID: 38504533]
Zhenxian Li, Haimei Zhu, Hao Liu, Dayue Liu, Jianhe Liu, Yi Zhang, Zhang Qin, Yijia Xu, Yuan Peng, Lihua Ruan, Jintao Li, Yao He, Bin Liu, Yun Long. Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin. Journal of nanobiotechnology. 2024 Mar; 22(1):129. doi: 10.1186/s12951-024-02389-5. [PMID: 38528554]
Hui Liu, Dan Guo, Jiao Wang, Wenxu Zhang, Zechao Zhu, Kunyuan Zhu, Shijun Bi, Pengyu Pan, Guobiao Liang. Aloe-emodin from Sanhua Decoction inhibits neuroinflammation by regulating microglia polarization after subarachnoid hemorrhage. Journal of ethnopharmacology. 2024 Mar; 322(?):117583. doi: 10.1016/j.jep.2023.117583. [PMID: 38122912]
Xin Dong, Ruijia Wen, Yuanyuan Xiong, Xiaotong Jia, Xiwen Zhang, Xin Li, Liangyou Zhang, Zhibin Li, Shu Zhang, Yanna Yu, Qiang Li, Xingbo Wu, Haitao Tu, Zixin Chen, Shaoxiang Xian, Lingjun Wang, Chao Wang, Lianqun Jia, Junyan Wang, Gangyi Chen. Emodin alleviates CRS4-induced mitochondrial damage via activation of the PGC1α signaling. Phytotherapy research : PTR. 2024 Mar; 38(3):1345-1357. doi: 10.1002/ptr.8091. [PMID: 38198804]
Na Zhang, Fengyi Lv, He Xiao, Bojiao Yi, Mingguo Shao, Hongbao Liang, Yonggang Wang, Na Guo, Jingchun Yao, Yongxia Guan, Guimin Zhang. Synergistic and attenuated effects and molecular biological mechanisms of Shouhui Tongbian capsule in the treatment of slow transit constipation based on UPLC-MS/MS, network pharmacology and animal experimental validation. Journal of pharmaceutical and biomedical analysis. 2024 Feb; 239(?):115846. doi: 10.1016/j.jpba.2023.115846. [PMID: 38039873]
Ruojun Du, Lichun Ye, Xinyan Chen, Yan Meng, Lei Zhou, Qiao Chen, Guohua Zheng, Junjie Hu, Zhaohua Shi. Screening of Key Components for Melanogenesis Inhibition of Polygonum cuspidatum Extract Based on the Spectrum-Effect Relationship and Molecular Docking. Molecules (Basel, Switzerland). 2024 Feb; 29(4):. doi: 10.3390/molecules29040857. [PMID: 38398609]
L I Xiuyan, Luo Yuting, Wang Jinhui, D U Zhimin. Formulation, characterization and and evaluation of aloe-emodin-loaded solid dispersions for dissolution enhancement. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Feb; 44(1):54-62. doi: 10.19852/j.cnki.jtcm.20231110.002. [PMID: 38213239]
Lixin Du, Huiling Lu, Yifei Xiao, Zhihua Guo, Ya Li. Prediction and analysis of quality markers for Chuantieling gel patches based on HPLC fingerprinting and network pharmacology. Biomedical chromatography : BMC. 2024 Feb; 38(2):e5773. doi: 10.1002/bmc.5773. [PMID: 38048642]
Jiali Wu, Yaokun Pang, Dan Liu, Jianxia Sun, Weibin Bai. Photodynamic Inactivation of Staphylococcus aureus Using Aloe-emodin as Photosensitizer. Food research international (Ottawa, Ont.). 2024 Feb; 178(?):113959. doi: 10.1016/j.foodres.2024.113959. [PMID: 38309912]
Lifang Wang, Haijao Wang, Jingjing Niu, Honggang Chen, Meng Wang, Zhigang Yang, Shaohua Wang, Xiuxia Sun, Yanbin Shi. Cholesterol-lowering effects of rhubarb free anthraquinones and their mechanism of action. European journal of pharmacology. 2024 Jan; ?(?):176348. doi: 10.1016/j.ejphar.2024.176348. [PMID: 38286356]
Changyudong Huang, Yiqiong Zhang, Yongjie Xu, Sijia Wei, Tingting Yang, Shuang Wang, Chengcheng Li, Hairong Lin, Xing Li, Shuyun Zhao, Liying Zhu, Wei Pan. Prepared radix polygoni multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition. Aging. 2024 Jan; 16(?):. doi: 10.18632/aging.205485. [PMID: 38284886]
Young-Seon Kim, Ji-Hye Han, Chang-Hoon Lim, Xue-Quan Fang, Hyeock-Soon Jang, Sang-Yun Lee, Woo-Jong Yim, Ji-Hong Lim. Effects of Fermented Polygonum cuspidatum on the Skeletal Muscle Functions. Nutrients. 2024 Jan; 16(2):. doi: 10.3390/nu16020305. [PMID: 38276543]
Yan Ye, Wenzhen Zhong, Ruifeng Luo, Hongzhi Wen, Ziyang Ma, Shanshan Qi, Xiaoqin Han, Wenbiao Nie, Degui Chang, Runchun Xu, Naijing Ye, Fei Gao, Peihai Zhang. Thermosensitive hydrogel with emodin-loaded triple-targeted nanoparticles for a rectal drug delivery system in the treatment of chronic non-bacterial prostatitis. Journal of nanobiotechnology. 2024 Jan; 22(1):33. doi: 10.1186/s12951-023-02282-7. [PMID: 38238760]
Qiang Huang, Meiling Fan, Fenglan Ji, Yuqi Wang, Hongyue Ding, Jie Xu, Xin Wang, Bo Liu, Bei Wang, Xinmiao Yu, Zhidong Qiu, Fan Yao. The safety evaluation of Shenze Shugan capsule and mechanism of apoptosis induced by five potentially nephrotoxic components. Journal of ethnopharmacology. 2024 Jan; 324(?):117777. doi: 10.1016/j.jep.2024.117777. [PMID: 38219879]
Fang Zhang, Rui Wu, Yanfang Liu, Shu Dai, Xinyan Xue, Xiaohong Gong, Yunxia Li. Comparative Pharmacokinetic Study of Rhubarb Anthraquinones in Normal and Nonalcoholic Fatty Liver Disease Rats. European journal of drug metabolism and pharmacokinetics. 2024 Jan; 49(1):111-121. doi: 10.1007/s13318-023-00875-z. [PMID: 38112917]
Mohamed Mendili, Ayda Khadhri, Francesca Sabatini, Ilaria Degano, Samira Aschi-Smiti. Parietin, the Vibrant Natural Dye in Xanthoria parietina. Chemistry & biodiversity. 2024 Jan; 21(1):e202301357. doi: 10.1002/cbdv.202301357. [PMID: 38072912]
Shuxiang Zhang, Zhongdi Huang, Huanhuan Xu, Qihua Liu, Zhou Jiang, Caiping Yin, Guomin Han, Wei Zhang, Yinglao Zhang. Biological control of wheat powdery mildew disease by the termite-associated fungus Aspergillus chevalieri BYST01 and potential role of secondary metabolites. Pest management science. 2023 Dec; ?(?):. doi: 10.1002/ps.7938. [PMID: 38105413]
Yanli Wang, Siwei Zhong, Ke Yang, Ruifeng Luo, Linxin Dai, Wenzhen Zhong, Yan Ye, Chaomei Fu, Dasheng Lin, Nan Li, Jianping Chen, Chuan Zheng, Shu Fu, Fei Gao. β-1,3-d-glucan particles-based "nest" protected co-loaded Rhein and Emodin regulates microbiota and intestinal immunity for ulcerative colitis treatment. International journal of biological macromolecules. 2023 Dec; 260(Pt 2):128818. doi: 10.1016/j.ijbiomac.2023.128818. [PMID: 38103669]
Si Liu, Xiao-Hua Luo, Yu-Feng Liu, Christos C Zouboulis, Ge Shi. Emodin exhibits anti-acne potential by inhibiting cell growth, lipogenesis, and inflammation in human SZ95 sebocytes. Scientific reports. 2023 12; 13(1):21576. doi: 10.1038/s41598-023-48709-x. [PMID: 38062074]
Chen Wang, Lulu Wu, Runjin Zhou, Cuiwen Song, Peng Chen, Shiying Huang, Ahsan Ali Khan, Deng Lu, Yong Hu, Lukui Chen. Integration of microbiota and metabolomics reveals the analgesic mechanisms of emodin against neuropathic pain. International immunopharmacology. 2023 Dec; 125(Pt A):111170. doi: 10.1016/j.intimp.2023.111170. [PMID: 37944218]
Lin Zhou, Xiaohui Wang, Jinlan Xia, Liyuan Zhang, Lianping Xue, Qingquan Jia, Zhihui Fu, Zhi Sun. Pharmacokinetic-pharmacodynamic modeling of the active components of Shenkang injection in rats with chronic renal failure and its protective effect on damaged renal cells. Biopharmaceutics & drug disposition. 2023 Dec; 44(6):406-419. doi: 10.1002/bdd.2377. [PMID: 37679901]
Jie Tang, Lixiang Wang, Mengge Shi, Shuaixia Feng, Tong Zhang, Han Han. Study on the mechanism of Shuganzhi Tablet against nonalcoholic fatty liver disease and lipid regulation effects of its main substances in vitro. Journal of ethnopharmacology. 2023 Nov; 316(?):116780. doi: 10.1016/j.jep.2023.116780. [PMID: 37311504]
Ruland Tchuinkeu Nguengang, Billy Toussie Tchegnitegni, Joel Eddy Terence Ateba, Georges Bellier Tabekoueng, Angelbert Fusi Awantu, Jean Jules Kezetas Bankeu, Jean Rodolphe Chouna, Celine Nguefeu Nkenfou, Norbert Sewald, Bruno Ndjakou Lenta. Antibacterial constituents of Rumex nepalensis spreng and its emodin derivatives. Natural product research. 2023 Nov; 37(23):3935-3946. doi: 10.1080/14786419.2022.2162894. [PMID: 36584290]
Hao Chai, Fangfang Xu, Jixia Wang, Yuxin Zhang, Xiaomin Xie, Han Zhou, Yanfang Liu, Xinmiao Liang, Aoxue Wang. Profiling CCR3 target pathways for discovering novel antagonists from natural products using label-free cell phenotypic assays. Chemico-biological interactions. 2023 Nov; 385(?):110732. doi: 10.1016/j.cbi.2023.110732. [PMID: 37788752]
Estera Okon, Katarzyna Gaweł-Bęben, Agata Jarzab, Wojciech Koch, Wirginia Kukula-Koch, Anna Wawruszak. Therapeutic Potential of 1,8-Dihydroanthraquinone Derivatives for Breast Cancer. International journal of molecular sciences. 2023 Oct; 24(21):. doi: 10.3390/ijms242115789. [PMID: 37958772]
Estera Okon, Maryna Koval, Anna Wawruszak, Adrianna Slawinska-Brych, Katarzyna Smolinska, Myroslav Shevera, Andrzej Stepulak, Wirginia Kukula-Koch. Emodin-8-O-Glucoside-Isolation and the Screening of the Anticancer Potential against the Nervous System Tumors. Molecules (Basel, Switzerland). 2023 Oct; 28(21):. doi: 10.3390/molecules28217366. [PMID: 37959784]
Huijuan Lv, Jingjing Niu, Wenhao Pan, Yudong Wang, Lifang Wang, Meng Wang, Yali Shi, Guifang Zhang, Bandar Al Hamyari, Shaohua Wang, Xuefeng Li, Yanbin Shi. Stool-softening effect and action mechanism of free anthraquinones extracted from Rheum palmatum L. on water deficit-induced constipation in rats. Journal of ethnopharmacology. 2023 Oct; 319(Pt 3):117336. doi: 10.1016/j.jep.2023.117336. [PMID: 37907143]
Xin Zhan, Rui Wang, Manman Zhang, Yuejiao Li, Tao Sun, Jie Chen, Jishun Li, Tong Liu. Trichoderma derived emodin competes with ExpR and ExpI of Pectobacterium carotovorum subsp. Carotovorum to biocontrol bacterial soft rot. Pest management science. 2023 Oct; ?(?):. doi: 10.1002/ps.7835. [PMID: 37831609]
Meng Yu, Xin-Yu Kong, Tong-Tong Chen, Zhong-Mei Zou. In vivo metabolism combined network pharmacology to identify anti-constipation constituents in Aloe barbadensis Mill. Journal of ethnopharmacology. 2023 Sep; 319(Pt 1):117200. doi: 10.1016/j.jep.2023.117200. [PMID: 37726070]
Jing Ji, Pengyu Tao, Qian Wang, Mengmeng Cui, Mingfeng Cao, Yuzhen Xu. Emodin attenuate diabetic kidney disease by inhibiting ferroptosis via up regulating Nrf2 expression. Aging. 2023 Aug; 15(?):. doi: 10.18632/aging.204933. [PMID: 37552124]
Jingxiao Yang, Yuanqing Wang, Xiong Cai, Binqing Qu, Ye Zhang, Zhicheng Sun, Jianye Yan. Comparative pharmacokinetics and tissue distribution of polydatin, resveratrol, and emodin after oral administration of Huzhang and Huzhang-Guizhi herb-pair extracts to rats. Journal of ethnopharmacology. 2023 Aug; ?(?):117010. doi: 10.1016/j.jep.2023.117010. [PMID: 37557937]
Antonia Otoo, Armin Czika, Jones Lamptey, Jun-Pu Yang, Qian Feng, Mei-Jiao Wang, Ying-Xiong Wang, Yu-Bin Ding. Emodin improves glucose metabolism and ovarian function in PCOS mice via the HMGB1/TLR4/NF-ĸB molecular pathway. Reproduction (Cambridge, England). 2023 Aug; ?(?):. doi: 10.1530/rep-22-0449. [PMID: 37651270]
Miao Xing, Xiaoyu Ma, Xi Wang, Haoze Wang, Minjuan Xie, Ziwen Zhang, Jie Zhou. Emodin disrupts the Notch1/Nrf2/GPX4 antioxidant system and promotes renal cell ferroptosis. Journal of applied toxicology : JAT. 2023 Jul; ?(?):. doi: 10.1002/jat.4509. [PMID: 37393915]
Xia Cao, Tianwen Deng, Qin Zhu, Jianping Wang, Wenwan Shi, Qi Liu, Qintong Yu, Wenwen Deng, Jiangnan Yu, Qilong Wang, Gao Xiao, Ximing Xu. Photothermal Therapy Mediated Hybrid Membrane Derived Nano-formulation for Enhanced Cancer Therapy. AAPS PharmSciTech. 2023 Jun; 24(6):146. doi: 10.1208/s12249-023-02594-9. [PMID: 37380936]
Ying He, Junmin Xi, Jianguo Fang, Baoxin Zhang, Wenqing Cai. Aloe-emodin alleviates doxorubicin-induced cardiotoxicity via inhibition of ferroptosis. Free radical biology & medicine. 2023 Jun; 206(?):13-21. doi: 10.1016/j.freeradbiomed.2023.06.025. [PMID: 37364691]
Yudan Mei, Xiaoyu Tong, Yumei Hu, Wenjun Liu, Jiajia Wang, Kaihong Lv, Xu Li, Liang Cao, Zhenzhong Wang, Wei Xiao, Xia Gao. Comparative pharmacokinetics of six bioactive components of Shen-Wu-Yi-Shen tablets in normal and chronic renal failure rats based on UPLC-TSQ-MS/MS. Journal of ethnopharmacology. 2023 Jun; 317(?):116818. doi: 10.1016/j.jep.2023.116818. [PMID: 37348793]
Hong-Hong Ma, Jing Zhang, Ci-Qin Li, Li-Wei Zou. Discovery of anthraquinones as DPP-IV inhibitors: Structure-activity relationships and inhibitory mechanism. Fitoterapia. 2023 May; ?(?):105549. doi: 10.1016/j.fitote.2023.105549. [PMID: 37244503]
H Wang, M Li, S Li, J Shi, L Huang, S Cheng, C Zou, H Yan. [Spectrum-effect relationship of total anthraquinone extract of Cassia seeds against fluorouracil-induced liver injury in mice]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2023 May; 43(5):825-831. doi: 10.12122/j.issn.1673-4254.2023.05.19. [PMID: 37313825]
Xueying Shi, Bingqian Huang, Jingyi Zhu, Takuji Yamaguchi, Ailing Hu, Masahiro Tabuchi, Daisuke Watanabe, Seiichiro Yoshikawa, Shinobu Mizushima, Akio Mizushima, Shilin Xia. A network pharmacology-based investigation of emodin against pancreatic adenocarcinoma. Medicine. 2023 May; 102(20):e33521. doi: 10.1097/md.0000000000033521. [PMID: 37335741]
Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
Hanaa M Sayed, Mahmoud A Ramadan, Heba H Salem, Iqrar Ahmad, Harun Patel, Marwa A A Fayed. Phytochemical Investigation, In silico/In vivo Analgesic, and Anti-inflammatory Assessment of the Egyptian Cassia occidentalis L. Steroids. 2023 May; 196(?):109245. doi: 10.1016/j.steroids.2023.109245. [PMID: 37141980]
Xinyue Wang, Shengjie Yang, Yujuan Li, Xiao Jin, Jing Lu, Min Wu. Role of emodin in atherosclerosis and other cardiovascular diseases: Pharmacological effects, mechanisms, and potential therapeutic target as a phytochemical. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 May; 161(?):114539. doi: 10.1016/j.biopha.2023.114539. [PMID: 36933375]
Liqing Wang, Menghan Chen, Qihui Sun, Yong Yang, Rong Rong. Discovery of the potential neuraminidase inhibitors from Polygonum cuspidatum by ultrafiltration combined with mass spectrometry guided by molecular docking. Journal of separation science. 2023 May; 46(10):e2200937. doi: 10.1002/jssc.202200937. [PMID: 36905353]
Qiuhui Ren, Wouter Bakker, Laura de Haan, Ivonne M C M Rietjens, Hans Bouwmeester. Induction of Nrf2-EpRE-mediated gene expression by hydroxyanthraquinones present in extracts from traditional Chinese medicine and herbs. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Apr; 176(?):113802. doi: 10.1016/j.fct.2023.113802. [PMID: 37116774]
Ding Tang, Chen Wang, Zhiqi Gu, Jiadong Li, Lu Jin, Juan Li, Zhixin Wang, Ren-Wang Jiang. Discovery of anti-allergic components in Guomingkang Formula using sensitive HEMT biochips coupled with in vitro and in vivo validation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Apr; 115(?):154837. doi: 10.1016/j.phymed.2023.154837. [PMID: 37126969]
Yixiu Zhao, Na Sun, Xia Song, Jia Zhu, Tianshuo Wang, Zhiqi Wang, Yuanyuan Yu, Jing Ren, Huan Chen, Tingting Zhan, Jiaying Tian, Chunyue Ma, Jian Huang, Jinhui Wang, Yan Zhang, Baofeng Yang. A novel small molecule AdipoR2 agonist ameliorates experimental hepatic steatosis in hamsters and mice. Free radical biology & medicine. 2023 Apr; 203(?):69-85. doi: 10.1016/j.freeradbiomed.2023.04.001. [PMID: 37044149]
Si Li, Xi Wu, Yue Ma, Hua Zhang, Wen Chen. Prediction and verification of the active ingredients and potential targets of Erhuang Quzhi Granules on non-alcoholic fatty liver disease based on network pharmacology. Journal of ethnopharmacology. 2023 Apr; ?(?):116435. doi: 10.1016/j.jep.2023.116435. [PMID: 37023836]
Ya-Peng Liu, Wang Zhang, Xin-Jie Liu, Huan Wu, An Zhou. [Determination of complexation ability of rhubarb with copper ions by ultra-high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2023 Apr; 41(4):323-329. doi: 10.3724/sp.j.1123.2022.06020. [PMID: 37005919]
Yuman Xie, Li Liu, Junzuo Zheng, Kun Shi, Wenqi Ai, Xuesong Zhang, Ping Wang, Zhou Lan, Lvyi Chen. Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma ameliorate scopolamine-induced cognitive impairment by regulating the cholinergic and synaptic associated proteins. Journal of ethnopharmacology. 2023 Mar; 311(?):116400. doi: 10.1016/j.jep.2023.116400. [PMID: 37003402]
Yue Hu, Lin Yang, Yu Lai. Recent findings regarding the synergistic effects of emodin and its analogs with other bioactive compounds: Insights into new mechanisms. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Mar; 162(?):114585. doi: 10.1016/j.biopha.2023.114585. [PMID: 36989724]
Jinjin Liu, Junyi Yin, Xiaojun Huang, Cencen Liu, Liuyun Hu, Yansheng Huang, Fang Geng, Shaoping Nie. Anthraquinone Removal from Cassia obtusifolia Seed Water Extract Using Baking, Stir-Frying, and Adsorption Treatments: Effects on the Chemical Composition, Physicochemical Properties of Polysaccharides, and Antioxidant Activities of the Water Extract. Journal of agricultural and food chemistry. 2023 Mar; ?(?):. doi: 10.1021/acs.jafc.3c00345. [PMID: 36971230]
Fan Wu, Yan Wang, Quanxi Mei, Qinhua Chen, Chengpeng Sun, Xia Lv, Lei Feng, Chao Wang, Yanyan Zhang, Bangjiang Fang, Xiaokui Huo, Xiangge Tian, Xiaochi Ma. UGTs-mediated metabolic interactions contribute to enhanced anti-inflammation activity of Jinhongtang. Journal of ethnopharmacology. 2023 Mar; 304(?):116016. doi: 10.1016/j.jep.2022.116016. [PMID: 36535328]
Ragavendran Chinnasamy, Balasubramani Govindasamy, Manigandan Venkatesh, Sivanandam Magudeeswaran, Arulbalachandran Dhanarajan, Natarajan Devarajan, Peijnenburg Willie, Vivekanandhan Perumal, Supamit Mekchay, Patcharin Krutmuang. Bio-efficacy of insecticidal molecule emodin against dengue, filariasis, and malaria vectors. Environmental science and pollution research international. 2023 Mar; ?(?):. doi: 10.1007/s11356-023-26290-0. [PMID: 36934179]
Maliha Fatima, Arshia Amin, Metab Alharbi, Sundas Ishtiaq, Wasim Sajjad, Faisal Ahmad, Sajjad Ahmad, Faisal Hanif, Muhammad Faheem, Atif Ali Khan Khalil. Quorum Quenchers from Reynoutria japonica in the Battle against Methicillin-Resistant Staphylococcus aureus (MRSA). Molecules (Basel, Switzerland). 2023 Mar; 28(6):. doi: 10.3390/molecules28062635. [PMID: 36985607]
Xu Wang, Guode Zhao, Chengguo Ju, Lingwen Dong, Yuyang Liu, Zifang Ding, Weiwei Li, Ying Peng, Jiang Zheng. Reduction of emodin-8-O-ß-D-glucoside content participates in processing-based detoxification of polygoni multiflori radix. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154750. doi: 10.1016/j.phymed.2023.154750. [PMID: 36990007]
Wen Jiang, Zhan Liu, Shuang Wu, Ting Meng, Li-Li Xu, Jin-Feng Liu, Xi-Wu Yan, Cheng Chang. Neuroprotection of Emodin by Inhibition of Microglial NLRP3 Inflammasome-Mediated Pyroptosis. Journal of integrative neuroscience. 2023 Mar; 22(2):48. doi: 10.31083/j.jin2202048. [PMID: 36992603]
Maryam Malmir, Katelene Lima, Sérgio Póvoas Camões, Vera Manageiro, Maria Paula Duarte, Joana Paiva Miranda, Rita Serrano, Isabel Moreira da Silva, Beatriz Silva Lima, Manuela Caniça, Olga Silva. Identification of Marker Compounds and In Vitro Toxicity Evaluation of Two Portuguese Asphodelus Leaf Extracts. Molecules (Basel, Switzerland). 2023 Mar; 28(5):. doi: 10.3390/molecules28052372. [PMID: 36903618]
Shanlin Chen, Xiaoxue Guan, Lei Xie, Chuanyu Liu, Chunhong Li, Min He, Jiahua Hu, Hui Fan, Quanwen Li, Liuping Xie, Mingqing Yang, Xiaoling Zhang, Shengjun Xiao, Jianhong Tang. Aloe-emodin targets multiple signaling pathways by blocking ubiquitin-mediated degradation of DUSP1 in nasopharyngeal carcinoma cells. Phytotherapy research : PTR. 2023 Mar; ?(?):. doi: 10.1002/ptr.7793. [PMID: 36866539]
HaoShang, Xinhua Jia, Huaman Liu, Xinyue Zhang, Yumeng Shao. A comprehensive review of emodin in fibrosis treatment. Fitoterapia. 2023 Mar; 165(?):105358. doi: 10.1016/j.fitote.2022.105358. [PMID: 36436587]
Feng-Pu Xie, Nan Wang, Jing Gao, Gang Zhang, Zhong-Xing Song, Yuan-Yuan Li, Ya-Li Zhang, Duo-Yi Wang, Rui Li, Mi-Mi Liu, Zhi-Shu Tang. [Variation and interaction mechanism between active components in Rheum officinale and rhizosphere soil microorganisms under drought stress]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Mar; 48(6):1498-1509. doi: 10.19540/j.cnki.cjcmm.20221208.104. [PMID: 37005837]
Dongpeng Wang, Jufeng Duan, Xiao-Jing Chen, Kaiqi Liu, Yingying Guo, Run Shi, Sha Li, Ming Liu, Lijun Zhao, Bei Li, Hongtao Liu, Minglun Li, Yibin Feng, Hongliang Li, Xuanbin Wang. Pharmacokinetic characteristics of emodin in polygoni Multiflori Radix Praeparata. Journal of ethnopharmacology. 2023 Mar; 303(?):115945. doi: 10.1016/j.jep.2022.115945. [PMID: 36435407]
Jing-Ting Zhang, Min-Feng Wu, Ming-Hua Ma, Liang Zhao, Jian-Yong Zhu, Hua Nian, Fu-Lun Li. Research on the wound healing effect of Shengji Huayu Formula ethanol extract-derived fractions in streptozotocin-induced diabetic ulcer rats. BMC complementary medicine and therapies. 2023 Mar; 23(1):67. doi: 10.1186/s12906-023-03894-0. [PMID: 36859252]
Ganesh Dakne, Mohamad Taleuzzaman, Mohammad Sarafroz, Pankaj Yadav, Yasmin Khatoon, Ziyaul Haque, Sufiyan Ahmad. Aloe-emodin quantification using HPTLC and RP-UHPLC in extracts and commercial herbal formulations: Evaluation of antimicrobial and antioxidant effects. Recent advances in anti-infective drug discovery. 2023 Feb; ?(?):. doi: 10.2174/2772434418666230222085606. [PMID: 36815640]
Lingling Wang, Guoying Zhou, Shuo Zhao, Yang Yang. Soluble protein content, bioactive compounds and the antioxidant activity in seeds of ten Rheum tanguticum lines from Qinghai-Tibet Plateau. Chemistry & biodiversity. 2023 Feb; ?(?):e202200901. doi: 10.1002/cbdv.202200901. [PMID: 36788177]
Ian Geddes Berlin, Charity Conlin Jennings, Spencer Shin, Jason Kenealey. Utilizing mixture design response surface methodology to determine effective combinations of plant derived compounds as prostate cancer treatments. Cancer reports (Hoboken, N.J.). 2023 Feb; ?(?):e1790. doi: 10.1002/cnr2.1790. [PMID: 36772872]
Peng Chen, Ning-Yu Huang, Bo Pang, Zeng-Jie Ye, Rui-Xi Luo, Chang Liu, Qian Gong, Chen Wang, Long Wang. Proteomic and metabolomic approaches elucidate the molecular mechanism of emodin against neuropathic pain through modulating the gamma-aminobutyric acid (GABA)-ergic pathway and PI3K/AKT/NF-κB pathway. Phytotherapy research : PTR. 2023 Feb; ?(?):. doi: 10.1002/ptr.7704. [PMID: 36723382]
Yongpeng Yao, ErLan Yang, Yuanyuan Pan, Xian Shu, Gang Liu. Mining an O-methyltransferase for de novo biosynthesis of physcion in Aspergillus nidulans. Applied microbiology and biotechnology. 2023 Feb; 107(4):1177-1188. doi: 10.1007/s00253-023-12373-y. [PMID: 36648527]
Lin Zhou, Xiaohan Hu, Chunyue Han, Xinru Niu, Lifeng Han, Haiyang Yu, Guixiang Pan, Zhifei Fu. Comprehensive investigation on the metabolism of emodin both in vivo and in vitro. Journal of pharmaceutical and biomedical analysis. 2023 Jan; 223(?):115122. doi: 10.1016/j.jpba.2022.115122. [PMID: 36327583]
Xiuli Zhang, Jing Li, Lili Guan. Emodin Reduces Inflammatory and Nociceptive Responses in Different Pain-and Inflammation-Induced Mouse Models. Combinatorial chemistry & high throughput screening. 2023; 26(5):989-1000. doi: 10.2174/1386207325666220514145252. [PMID: 35570550]
Ismail Badshah, Neelum Gul Qazi, Fawad Ali, Amber Mahmood Minhas, Arooj Mohsin Alvi, Mahmoud Kandeel, Muhammad Imran, Syed Shams Ul Hassan, Simona Bungau. Emodin alleviates chronic constriction injury-induced neuropathic pain and inflammation via modulating PPAR-gamma pathway. PloS one. 2023; 18(7):e0287517. doi: 10.1371/journal.pone.0287517. [PMID: 37440558]
Qi Yang, Yalan Luo, Peng Ge, Bowen Lan, Jin Liu, Haiyun Wen, Yinan Cao, Zhenxuan Sun, Guixin Zhang, Huiming Yuan, Lihua Zhang, Hailong Chen. Emodin Ameliorates Severe Acute Pancreatitis-Associated Acute Lung Injury in Rats by Modulating Exosome-Specific miRNA Expression Profiles. International journal of nanomedicine. 2023; 18(?):6743-6761. doi: 10.2147/ijn.s428924. [PMID: 38026528]
Jeong-Yub Kim, Chan-Woong Jung, Won Seok Lee, Hyeon-Jeong Jeong, Myung-Jin Park, Won Il Jang, Eun Ho Kim. Emodin coupled with high LET neutron beam-a novel approach to treat on glioblastoma. Journal of radiation research. 2022 Dec; 63(6):817-827. doi: 10.1093/jrr/rrac061. [PMID: 36253116]
Ding Tang, Chen Wang, Qianying Gan, Zhixin Wang, Renwang Jiang. Chemical composition-based characterization of the anti-allergic effect of Guominkang Formula on IgE-mediated mast cells activation and passive cutaneous anaphylaxis. Chinese journal of natural medicines. 2022 Dec; 20(12):925-936. doi: 10.1016/s1875-5364(22)60225-5. [PMID: 36549806]
Danni Feng, Zhongxiang Fang, Pangzhen Zhang. The melanin inhibitory effect of plants and phytochemicals: A systematic review. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Dec; 107(?):154449. doi: 10.1016/j.phymed.2022.154449. [PMID: 36126406]
Jia Yang, Gangdan Jiang, Kaiwen Ni, Liming Fan, Wang Tong, Junchao Yang. Emodin inhibiting epithelial-mesenchymal transition in pulmonary fibrosis through the c-MYC/miR-182-5p/ZEB2 axis. Phytotherapy research : PTR. 2022 Nov; ?(?):. doi: 10.1002/ptr.7680. [PMID: 36411986]
Jinlin Huo, Ting Wang, Bokai Wei, Xunlong Shi, Aidong Yang, Daofeng Chen, Jing Hu, Haiyan Zhu. Integrated network pharmacology and intestinal flora analysis to determine the protective effect of Xuanbai-Chengqi decoction on lung and gut injuries in influenza virus-infected mice. Journal of ethnopharmacology. 2022 Nov; 298(?):115649. doi: 10.1016/j.jep.2022.115649. [PMID: 35987410]
Ko-Hsuan Chen, Florencia Marcón, Jennifer Duringer, Ann Blount, Cheryl Mackowiak, Hui-Ling Liao. Leaf Mycobiome and Mycotoxin Profile of Warm-Season Grasses Structured by Plant Species, Geography, and Apparent Black-Stroma Fungal Structure. Applied and environmental microbiology. 2022 11; 88(21):e0094222. doi: 10.1128/aem.00942-22. [PMID: 36226941]
Guorong Cheng, Zhiqiang Liu, Zhong Zheng, Fengrui Song, Xiaoyu Zhuang, Shu Liu. Cell Metabolomics Reveals the Potential Mechanism of Aloe Emodin and Emodin Inhibiting Breast Cancer Metastasis. International journal of molecular sciences. 2022 Nov; 23(22):. doi: 10.3390/ijms232213738. [PMID: 36430215]
Chang Chen, Jiahui Qian, Xinyu Zhao, Xuyang Han, Xu Tang, Junfeng Gao, Yan Liu, Jinzhu Jiang, Binyu Wen. Metabolic profiling of emodin drug-induced liver injury and silybin treatment in rats using ultra-performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry: A metabolomic and mechanistic approach. Biomedical chromatography : BMC. 2022 Nov; 36(11):e5469. doi: 10.1002/bmc.5469. [PMID: 35904380]
Hui Jiang, Gao-Feng Shi, Yu-Xi Fang, You-Qian Liu, Qi Wang, Xian Zheng, Dong-Jian Zhang, Jian Zhang, Zhi-Qi Yin. Aloin A prevents ulcerative colitis in mice by enhancing the intestinal barrier function via suppressing the Notch signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154403. doi: 10.1016/j.phymed.2022.154403. [PMID: 36075180]
Jingsen Meng, Jiazhen Xu, Shanbo Yang, Wenjing Liu, Jun Zeng, Lingyu Shi, Jing Chang, Renshuai Zhang, Dongming Xing. Emodin lows NPC1L1-mediated cholesterol absorption as an uncompetitive inhibitor. Bioorganic & medicinal chemistry letters. 2022 11; 75(?):128974. doi: 10.1016/j.bmcl.2022.128974. [PMID: 36064125]
Feifei Qi, Wei Zhang, Yingying Xue, Ce Geng, Zhigang Jin, Jibin Li, Qiang Guo, Xuenian Huang, Xuefeng Lu. Microbial production of the plant-derived fungicide physcion. Metabolic engineering. 2022 11; 74(?):130-138. doi: 10.1016/j.ymben.2022.10.007. [PMID: 36328293]
Boran Ni, Yi Liu, Xue Gao, Mengru Cai, Jing Fu, Xingbin Yin, Jian Ni, Xiaoxv Dong. Isoliquiritigenin attenuates emodin-induced hepatotoxicity in vivo and in vitro through Nrf2 pathway. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Nov; 261(?):109430. doi: 10.1016/j.cbpc.2022.109430. [PMID: 35944824]
Jiawei Wang, Huixin Li, Zixuan Yang, Chunyue Huang, Yichun Sun, Xiao Hu. Elucidation of the mechanisms and molecular targets of Run-zao-zhi-yang capsule for itch based on network pharmacology, molecular docking and in vitro experiment. Combinatorial chemistry & high throughput screening. 2022 Oct; ?(?):. doi: 10.2174/1386207326666221031115440. [PMID: 36321233]
Bo Yuan, Nancy P Keller, Berl R Oakley, Jason E Stajich, Clay C C Wang. Manipulation of the Global Regulator mcrA Upregulates Secondary Metabolite Production in Aspergillus wentii Using CRISPR-Cas9 with In Vitro Assembled Ribonucleoproteins. ACS chemical biology. 2022 10; 17(10):2828-2835. doi: 10.1021/acschembio.2c00456. [PMID: 36197945]
Javad Sharifi-Rad, Jesús Herrera-Bravo, Senem Kamiloglu, Katia Petroni, Abhay Prakash Mishra, Margalida Monserrat-Mesquida, Antoni Sureda, Miquel Martorell, Dossymbetova Symbat Aidarbekovna, Zura Yessimsiitova, Alibek Ydyrys, Christophe Hano, Daniela Calina, William C Cho. Recent advances in the therapeutic potential of emodin for human health. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Oct; 154(?):113555. doi: 10.1016/j.biopha.2022.113555. [PMID: 36027610]
Yan Zhang, Lijun Wang, Liushen Lu, Meiling Liu, Zhenbo Yuan, Lifeng Yang, Changmei Liu, Shuping Huang, Yijian Rao. Highly efficient decontamination of tetracycline and pathogen by a natural product-derived Emodin/HAp photocatalyst. Chemosphere. 2022 Oct; 305(?):135401. doi: 10.1016/j.chemosphere.2022.135401. [PMID: 35738405]