Kaempferol (BioDeep_00000290764)

Main id: BioDeep_00000000279

Secondary id: BioDeep_00000270591

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


Kaempferol

化学式: C15H10O6 (286.0477)
中文名称: 山奈酚
谱图信息: 最多检出来源 Viridiplantae(plant) 19.56%

分子结构信息

SMILES: C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O
InChI: InChI=1/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H

描述信息

Annotation level-3
Annotation level-1
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.010
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.011
Acquisition and generation of the data is financially supported by the Max-Planck-Society
IPB_RECORD: 2141; CONFIDENCE confident structure
IPB_RECORD: 3341; CONFIDENCE confident structure
IPB_RECORD: 3321; CONFIDENCE confident structure
CONFIDENCE confident structure; IPB_RECORD: 3321
IPB_RECORD: 141; CONFIDENCE confident structure
Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer[1][2][3][4].
Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer[1][2][3][4].

同义名列表

4 个代谢物同义名

Kaempferol; Kempferol; Robigenin; Kaempferol



数据库引用编号

128 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1097 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ANG, CDKN1A, CYP1A1, ESR1, HPGDS, MAPK1, PRKAA2, TP53
Peripheral membrane protein 4 ACHE, CYP1A1, CYP1B1, ESR1
Endoplasmic reticulum membrane 2 CYP1A1, CYP1B1
Nucleus 10 ACHE, ANG, CDKN1A, ESR1, JUND, MAPK1, MPO, PPARA, PRKAA2, TP53
cytosol 8 ANG, CDKN1A, ESR1, HPGDS, IL1B, MAPK1, PRKAA2, TP53
dendrite 1 PRKAA2
nuclear body 1 CDKN1A
centrosome 2 MAPK1, TP53
nucleoplasm 9 CDKN1A, ESR1, HPGDS, JUND, MAPK1, MPO, PPARA, PRKAA2, TP53
RNA polymerase II transcription regulator complex 1 JUND
Cell membrane 3 ACHE, ESR1, MGAM
Cytoplasmic side 1 ESR1
Synapse 2 ACHE, MAPK1
cell surface 2 ACHE, ICAM1
Golgi apparatus 4 ACHE, ESR1, MAPK1, PRKAA2
growth cone 1 ANG
mitochondrial inner membrane 1 CYP1A1
neuromuscular junction 1 ACHE
neuronal cell body 2 ANG, PRKAA2
Cytoplasm, cytosol 1 IL1B
Lysosome 2 IL1B, MPO
plasma membrane 5 ACHE, ESR1, ICAM1, MAPK1, MGAM
Membrane 7 ACHE, CYP1B1, ESR1, ICAM1, MGAM, PRKAA2, TP53
apical plasma membrane 1 MGAM
axon 1 PRKAA2
caveola 1 MAPK1
extracellular exosome 4 ICAM1, MGAM, MMP9, MPO
endoplasmic reticulum 1 TP53
extracellular space 9 ACHE, ANG, CCL2, CXCL8, ICAM1, IL1B, IL4, MMP9, MPO
perinuclear region of cytoplasm 2 ACHE, CDKN1A
mitochondrion 4 CYP1A1, CYP1B1, MAPK1, TP53
protein-containing complex 3 CDKN1A, ESR1, TP53
intracellular membrane-bounded organelle 4 CYP1A1, CYP1B1, HPGDS, MPO
Microsome membrane 2 CYP1A1, CYP1B1
Single-pass type I membrane protein 1 ICAM1
Secreted 7 ACHE, ANG, CCL2, CXCL8, IL1B, IL4, MGAM
extracellular region 10 ACHE, ANG, CCL2, CXCL8, IL1B, IL4, MAPK1, MGAM, MMP9, MPO
Single-pass membrane protein 1 MGAM
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
Extracellular side 1 ACHE
transcription regulator complex 3 ESR1, JUND, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 MAPK1, TP53
external side of plasma membrane 1 ICAM1
Secreted, extracellular space, extracellular matrix 1 MMP9
actin cytoskeleton 1 ANG
nucleolus 3 ANG, CDKN1A, TP53
Early endosome 1 MAPK1
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 1 ICAM1
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton 1 TP53
Cytoplasm, cytoskeleton, spindle 1 MAPK1
focal adhesion 2 ICAM1, MAPK1
spindle 1 MAPK1
basement membrane 2 ACHE, ANG
Nucleus, PML body 1 TP53
PML body 1 TP53
collagen-containing extracellular matrix 2 ICAM1, MMP9
secretory granule 2 IL1B, MPO
nuclear speck 1 PRKAA2
Late endosome 1 MAPK1
chromatin 4 ESR1, JUND, PPARA, TP53
mitotic spindle 1 MAPK1
Chromosome 1 ANG
cytoskeleton 1 MAPK1
Nucleus, nucleolus 1 ANG
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 TP53
Membrane, caveola 1 MAPK1
tertiary granule membrane 1 MGAM
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 2 ANG, PRKAA2
euchromatin 1 ESR1
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 1 TP53
pseudopodium 1 MAPK1
azurophil granule 1 MPO
ficolin-1-rich granule lumen 2 MAPK1, MMP9
endoplasmic reticulum lumen 1 MAPK1
nuclear matrix 1 TP53
transcription repressor complex 2 JUND, TP53
tertiary granule lumen 1 MMP9
endocytic vesicle 1 ANG
Secreted, extracellular exosome 1 IL1B
azurophil granule lumen 2 MAPK1, MPO
immunological synapse 1 ICAM1
phagocytic vesicle lumen 1 MPO
[Isoform 1]: Nucleus 2 ESR1, TP53
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 MGAM
nucleotide-activated protein kinase complex 1 PRKAA2
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
transcription factor AP-1 complex 1 JUND
angiogenin-PRI complex 1 ANG
PCNA-p21 complex 1 CDKN1A
[Isoform H]: Cell membrane 1 ACHE


文献列表

  • Yunzhou Pu, Yicun Han, Yiran Ouyang, Haoze Li, Ling Li, Xinnan Wu, Liu Yang, Jingdong Gao, Lei Zhang, Jing Zhou, Qing Ji, Qing Song. Kaempferol inhibits colorectal cancer metastasis through circ_0000345 mediated JMJD2C/β-catenin signalling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155261. doi: 10.1016/j.phymed.2023.155261. [PMID: 38493716]
  • Yves Iradukunda, Jing-Yan Kang, Xiao-Bo Zhao, Xiao-Kang Fu, Stanislas Nsanzamahoro, Wei Ha, Yan-Ping Shi. Triple Sensing Modes for Triggered β-Galactosidase Activity Assays Based on Kaempferol-Deduced Silicon Nanoparticles and Biological Imaging of MCF-7 Breast Cancer Cells. ACS applied bio materials. 2024 May; 7(5):3154-3163. doi: 10.1021/acsabm.4c00185. [PMID: 38695332]
  • Qiuxiang Chen, Juan Wang, Lihua Sun, Bayinsilema Ba, Difei Shen. Mechanism of Astragalus membranaceus (Huangqi, HQ) for treatment of heart failure based on network pharmacology and molecular docking. Journal of cellular and molecular medicine. 2024 May; 28(10):e18331. doi: 10.1111/jcmm.18331. [PMID: 38780500]
  • Anna Balykina, Lidia Naida, Kürsat Kirkgöz, Viacheslav O Nikolaev, Ekaterina Fock, Michael Belyakov, Anastasiia Whaley, Andrei Whaley, Valentina Shpakova, Natalia Rukoyatkina, Stepan Gambaryan. Antiplatelet Effects of Flavonoid Aglycones Are Mediated by Activation of Cyclic Nucleotide-Dependent Protein Kinases. International journal of molecular sciences. 2024 Apr; 25(9):. doi: 10.3390/ijms25094864. [PMID: 38732081]
  • Kexin Chang, Kuangshi Fan, Hua Zhang, Qiong Wu, Yonghong Zhang, Le Wang, Hongcen Chen, Jinjin Tong, Defeng Cui. Fuzhengjiedu San inhibits porcine reproductive and respiratory syndrome virus by activating the PI3K/AKT pathway. PloS one. 2024; 19(5):e0283728. doi: 10.1371/journal.pone.0283728. [PMID: 38709810]
  • Xu Lian, Kaidi Fan, Xuemei Qin, Yuetao Liu. Amalgamated Pharmacoinformatics Study to Investigate the Mechanism of Xiao Jianzhong Tang against Chronic Atrophic Gastritis. Current computer-aided drug design. 2023 Jul; ?(?):. doi: 10.2174/1573409919666230720141115. [PMID: 37475552]
  • Lu Yan, Min-Yue Jiang, Xin-Sheng Fan. Research into the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula based on network pharmacology, metabolomics, and verification of AMPK/PPAR-γ pathway of active ingredients. Journal of ethnopharmacology. 2023 Jun; ?(?):116773. doi: 10.1016/j.jep.2023.116773. [PMID: 37308028]
  • Xiling Zhu, Yan Li, Xiaodong Wang, Yuanshe Huang, Jingxin Mao. Investigation of the mechanism of Prunella vulgaris in treatment of papillary thyroid carcinoma based on network pharmacology integrated molecular docking and experimental verification. Medicine. 2023 Apr; 102(17):e33360. doi: 10.1097/md.0000000000033360. [PMID: 37115092]
  • Yanhong Sun, Xiaoyan Duan, Fenghe Wang, Huixin Tan, Jiahuan Hu, Wanting Bai, Xinbo Wang, Baolian Wang, Jinping Hu. Inhibitory effects of flavonoids on glucose transporter 1 (GLUT1): From library screening to biological evaluation to structure-activity relationship. Toxicology. 2023 Mar; ?(?):153475. doi: 10.1016/j.tox.2023.153475. [PMID: 36870413]
  • Adeola Oluwatosin Adedara, Guilherme Wildner, Julia Sepel Loreto, Matheus Mulling Dos Santos, Amos Olalekan Abolaji, Nilda Vargas Barbosa. Kaempferol counteracts toxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in D. melanogaster: An implication of its mitoprotective activity. Neurotoxicology. 2022 Dec; 95(?):23-34. doi: 10.1016/j.neuro.2022.12.008. [PMID: 36592898]
  • Argyrios Periferakis, Konstantinos Periferakis, Ioana Anca Badarau, Elena Madalina Petran, Delia Codruta Popa, Ana Caruntu, Raluca Simona Costache, Cristian Scheau, Constantin Caruntu, Daniel Octavian Costache. Kaempferol: Antimicrobial Properties, Sources, Clinical, and Traditional Applications. International journal of molecular sciences. 2022 Nov; 23(23):. doi: 10.3390/ijms232315054. [PMID: 36499380]
  • Kaiyang Liu, Xi Chen, Yue Ren, Chaoqun Liu, Anlei Yuan, Lulu Zheng, Beiyan Li, Yanling Zhang. Identification of a novel farnesoid X receptor agonist, kaempferol-7-O-rhamnoside, a compound ameliorating drug-induced liver injury based on virtual screening and in vitro validation. Toxicology and applied pharmacology. 2022 11; 454(?):116251. doi: 10.1016/j.taap.2022.116251. [PMID: 36150480]
  • Ruyang Yu, Jia Zhong, Qilyu Zhou, Wei Ren, Zhongjie Liu, Yifei Bian. Kaempferol prevents angiogenesis of rat intestinal microvascular endothelial cells induced by LPS and TNF-α via inhibiting VEGF/Akt/p38 signaling pathways and maintaining gut-vascular barrier integrity. Chemico-biological interactions. 2022 Oct; 366(?):110135. doi: 10.1016/j.cbi.2022.110135. [PMID: 36049518]
  • Anand Kumar Sahu, Ashok Kumar Mishra. Photophysical Behavior of Plant Flavonols Galangin, Kaempferol, Quercetin, and Myricetin in Homogeneous Media and the DMPC Model Membrane: Unveiling the Influence of the B-Ring Hydroxylation of Flavonols. The journal of physical chemistry. B. 2022 04; 126(15):2863-2875. doi: 10.1021/acs.jpcb.2c00929. [PMID: 35404618]
  • Shiquan Chang, Xin Li, Yachun Zheng, Huimei Shi, Di Zhang, Bei Jing, Zhenni Chen, Guoqiang Qian, Guoping Zhao. Kaempferol exerts a neuroprotective effect to reduce neuropathic pain through TLR4/NF-ĸB signaling pathway. Phytotherapy research : PTR. 2022 Apr; 36(4):1678-1691. doi: 10.1002/ptr.7396. [PMID: 35234314]
  • Antoine Berger, Scott Latimer, Lauren R Stutts, Eric Soubeyrand, Anna K Block, Gilles J Basset. Kaempferol as a precursor for ubiquinone (coenzyme Q) biosynthesis: An atypical node between specialized metabolism and primary metabolism. Current opinion in plant biology. 2022 04; 66(?):102165. doi: 10.1016/j.pbi.2021.102165. [PMID: 35026487]
  • Xichuan Li, Ce Wang, Jinqian Chen, Xia Hu, Hao Zhang, Zhiying Li, Bei Lan, Wei Zhang, Yanjun Su, Chunze Zhang. Potential interactions among myricetin and dietary flavonols through the inhibition of human UDP-glucuronosyltransferase in vitro. Toxicology letters. 2022 Apr; 358(?):40-47. doi: 10.1016/j.toxlet.2022.01.007. [PMID: 35063619]
  • Tsung-Ming Yeh, Ching-Dong Chang, Shyh-Shyan Liu, Chi-I Chang, Wen-Ling Shih. Tea Seed Kaempferol Triglycoside Attenuates LPS-Induced Systemic Inflammation and Ameliorates Cognitive Impairments in a Mouse Model. Molecules (Basel, Switzerland). 2022 Mar; 27(7):. doi: 10.3390/molecules27072055. [PMID: 35408453]
  • Xiaoyan Li, Imran Khan, Guoxin Huang, Yiyan Lu, Liping Wang, Yuanyuan Liu, Linlin Lu, W L Wendy Hsiao, Zhongqiu Liu. Kaempferol acts on bile acid signaling and gut microbiota to attenuate the tumor burden in ApcMin/+ mice. European journal of pharmacology. 2022 Mar; 918(?):174773. doi: 10.1016/j.ejphar.2022.174773. [PMID: 35065044]
  • Agata Walkowiak, Kacper Wnuk, Michał Cyrankiewicz, Bogumiła Kupcewicz. Discrimination of Adulterated Ginkgo Biloba Products Based on 2T2D Correlation Spectroscopy in UV-Vis Range. Molecules (Basel, Switzerland). 2022 Jan; 27(2):. doi: 10.3390/molecules27020433. [PMID: 35056747]
  • Magdalena Kluska, Michał Juszczak, Jerzy Żuchowski, Anna Stochmal, Katarzyna Woźniak. Effect of Kaempferol and Its Glycoside Derivatives on Antioxidant Status of HL-60 Cells Treated with Etoposide. Molecules (Basel, Switzerland). 2022 Jan; 27(2):. doi: 10.3390/molecules27020333. [PMID: 35056649]
  • Xiaolin Xiao, Qichao Hu, Xinyu Deng, Kaiyun Shi, Wenwen Zhang, Yinxiao Jiang, Xiao Ma, Jinhao Zeng, Xiaoyin Wang. Old wine in new bottles: Kaempferol is a promising agent for treating the trilogy of liver diseases. Pharmacological research. 2022 01; 175(?):106005. doi: 10.1016/j.phrs.2021.106005. [PMID: 34843960]
  • Yifei Bian, Jiaqi Lei, Jia Zhong, Bo Wang, Yan Wan, Jinxin Li, Chaoyong Liao, Yang He, Zhongjie Liu, Koichi Ito, Bingkun Zhang. Kaempferol reduces obesity, prevents intestinal inflammation, and modulates gut microbiota in high-fat diet mice. The Journal of nutritional biochemistry. 2022 01; 99(?):108840. doi: 10.1016/j.jnutbio.2021.108840. [PMID: 34419569]
  • Wenling Tu, Yinjie Hong, Miaoan Huang, Meimei Chen, Huijuan Gan. Effect of kaempferol on hedgehog signaling pathway in rats with --chronic atrophic gastritis - Based on network pharmacological screening and experimental verification. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jan; 145(?):112451. doi: 10.1016/j.biopha.2021.112451. [PMID: 34839256]
  • Olha Mykhailenko, Vilma Petrikaite, Michal Korinek, Fang-Rong Chang, Mohamed El-Shazly, Chia-Hung Yen, Ivan Bezruk, Bing-Hung Chen, Chung-Fan Hsieh, Dmytro Lytkin, Liudas Ivanauskas, Victoriya Georgiyants, Tsong-Long Hwang. Pharmacological Potential and Chemical Composition of Crocus sativus Leaf Extracts. Molecules (Basel, Switzerland). 2021 Dec; 27(1):. doi: 10.3390/molecules27010010. [PMID: 35011243]
  • Huihao Tang, Lili Yang, Longlong Wu, Huimin Wang, Kaixian Chen, Huali Wu, Yiming Li. Kaempferol, the melanogenic component of Sanguisorba officinalis, enhances dendricity and melanosome maturation/transport in melanocytes. Journal of pharmacological sciences. 2021 Dec; 147(4):348-357. doi: 10.1016/j.jphs.2021.08.009. [PMID: 34663517]
  • Zhuo Feng, Changyuan Wang, Yue, Jin, Qiang Meng, Jingjing Wu, Huijun Sun. Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway. Pharmaceutical biology. 2021 Dec; 59(1):1106-1116. doi: 10.1080/13880209.2021.1961823. [PMID: 34403325]
  • Jing Jin, Yi-Qing Lv, Wei-Zhong He, Da Li, Ying Ye, Zai-Fa Shu, Jing-Na Shao, Jia-Hao Zhou, Ding-Mi Chen, Qing-Sheng Li, Jian-Hui Ye. Screening the Key Region of Sunlight Regulating the Flavonoid Profiles of Young Shoots in Tea Plants (Camellia sinensis L.) Based on a Field Experiment. Molecules (Basel, Switzerland). 2021 Nov; 26(23):. doi: 10.3390/molecules26237158. [PMID: 34885740]
  • Ritu Sharma, Rajinder Jindal, Caterina Faggio. Cassia fistula ameliorates chronic toxicity of cypermethrin in Catla catla. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2021 Oct; 248(?):109113. doi: 10.1016/j.cbpc.2021.109113. [PMID: 34153505]
  • Ayasa Ochiai, Mahmoud Ben Othman, Kazuichi Sakamoto. Kaempferol ameliorates symptoms of metabolic syndrome by improving blood lipid profile and glucose tolerance. Bioscience, biotechnology, and biochemistry. 2021 Sep; 85(10):2169-2176. doi: 10.1093/bbb/zbab132. [PMID: 34279554]
  • Ji-Nam Kang, Woo-Haeng Lee, So Youn Won, Saemin Chang, Jong-Pil Hong, Tae-Jin Oh, Si Myung Lee, Sang-Ho Kang. Systemic Expression of Genes Involved in the Plant Defense Response Induced by Wounding in Senna tora. International journal of molecular sciences. 2021 Sep; 22(18):. doi: 10.3390/ijms221810073. [PMID: 34576236]
  • Xueni Wang, Junjie Zhu, Huimin Yan, Mengyao Shi, Qiaoqi Zheng, Yu Wang, Yan Zhu, Lin Miao, Xiumei Gao. Kaempferol inhibits benign prostatic hyperplasia by resisting the action of androgen. European journal of pharmacology. 2021 Sep; 907(?):174251. doi: 10.1016/j.ejphar.2021.174251. [PMID: 34129879]
  • Fangfang Tie, Jin Ding, Na Hu, Qi Dong, Zhi Chen, Honglun Wang. Kaempferol and Kaempferide Attenuate Oleic Acid-Induced Lipid Accumulation and Oxidative Stress in HepG2 Cells. International journal of molecular sciences. 2021 Aug; 22(16):. doi: 10.3390/ijms22168847. [PMID: 34445549]
  • Lixia Li, Rui Wang, Huaiyue Hu, Xu Chen, Zhongqiong Yin, Xiaoxia Liang, Changliang He, Lizi Yin, Gang Ye, Yuanfeng Zou, Guizhou Yue, Huaqiao Tang, Renyong Jia, Xu Song. The antiviral activity of kaempferol against pseudorabies virus in mice. BMC veterinary research. 2021 Jul; 17(1):247. doi: 10.1186/s12917-021-02953-3. [PMID: 34275451]
  • Arathi H S, Elisa Bernklau. Context-Dependent Effect of Dietary Phytochemicals on Honey Bees Exposed to a Pesticide, Thiamethoxam. Journal of insect science (Online). 2021 Jul; 21(4):. doi: 10.1093/jisesa/ieab053. [PMID: 34374762]
  • Monika Beszterda, Rafał Frański. Elucidation of glycosylation sites of kaempferol di-O-glycosides from methanolic extract of the leaves of Prunus domestica subsp. syriaca. Rapid communications in mass spectrometry : RCM. 2021 Jun; 35(12):e9100. doi: 10.1002/rcm.9100. [PMID: 33830532]
  • Yuan Yuan, Yanyu Zhai, Jingjiong Chen, Xiaofeng Xu, Hongmei Wang. Kaempferol Ameliorates Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Ferroptosis by Activating Nrf2/SLC7A11/GPX4 Axis. Biomolecules. 2021 06; 11(7):. doi: 10.3390/biom11070923. [PMID: 34206421]
  • Peng Yuan, Xifeng Sun, Xiao Liu, Georg Hutterer, Karl Pummer, Boris Hager, Zhangqun Ye, Zhiqiang Chen. Kaempferol alleviates calcium oxalate crystal-induced renal injury and crystal deposition via regulation of the AR/NOX2 signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jun; 86(?):153555. doi: 10.1016/j.phymed.2021.153555. [PMID: 33852977]
  • Andrea Magnavacca, Stefano Piazza, Anna Cammisa, Marco Fumagalli, Giulia Martinelli, Flavio Giavarini, Enrico Sangiovanni, Mario Dell'Agli. Ribes nigrum Leaf Extract Preferentially Inhibits IFN-γ-Mediated Inflammation in HaCaT Keratinocytes. Molecules (Basel, Switzerland). 2021 May; 26(10):. doi: 10.3390/molecules26103044. [PMID: 34065200]
  • Tariq Javed, Sarwat Ali Raja, Kashif Ur Rehman, Samrah Khalid, Namrah Khalid, Sana Riaz. In silico bimolecular characterization of anticancer phytochemicals from Fagonia indica. Pakistan journal of pharmaceutical sciences. 2021 May; 34(3):883-889. doi: ". [PMID: 34602410]
  • Paulina Laszuk, Aneta D Petelska. Interactions between Phosphatidylcholine and Kaempferol or Myristicin: Langmuir Monolayers and Microelectrophoretic Studies. International journal of molecular sciences. 2021 Apr; 22(9):. doi: 10.3390/ijms22094729. [PMID: 33946951]
  • Luis Fernando Méndez-López, Pierluigi Caboni, Eder Arredondo-Espinoza, Juan J J Carrizales-Castillo, Isaías Balderas-Rentería, María Del Rayo Camacho-Corona. Bioassay-Guided Identification of the Antiproliferative Compounds of Cissus trifoliata and the Transcriptomic Effect of Resveratrol in Prostate Cancer Pc3 Cells. Molecules (Basel, Switzerland). 2021 Apr; 26(8):. doi: 10.3390/molecules26082200. [PMID: 33920405]
  • Ashraf Al-Brakati, Alaa Jameel A Albarakati, Maha S Lokman, Abdulrahman Theyab, Mohammad Algahtani, Salah Menshawi, Ohoud D AlAmri, Naif E Al Omairi, Ehab A Essawy, Rami B Kassab, Ahmed E Abdel Moneim. Possible Role of Kaempferol in Reversing Oxidative Damage, Inflammation, and Apoptosis-Mediated Cortical Injury Following Cadmium Exposure. Neurotoxicity research. 2021 Apr; 39(2):198-209. doi: 10.1007/s12640-020-00300-2. [PMID: 33141427]
  • Magdalena Kluska, Michał Juszczak, Jerzy Żuchowski, Anna Stochmal, Katarzyna Woźniak. Kaempferol and Its Glycoside Derivatives as Modulators of Etoposide Activity in HL-60 Cells. International journal of molecular sciences. 2021 Mar; 22(7):. doi: 10.3390/ijms22073520. [PMID: 33805363]
  • Wu Luo, Xiaojun Chen, Lin Ye, Xuemei Chen, Wenjing Jia, Yanni Zhao, Aleksandr V Samorodov, Yali Zhang, Xueting Hu, Fei Zhuang, Jianchang Qian, Chao Zheng, Guang Liang, Yi Wang. Kaempferol attenuates streptozotocin-induced diabetic nephropathy by downregulating TRAF6 expression: The role of TRAF6 in diabetic nephropathy. Journal of ethnopharmacology. 2021 Mar; 268(?):113553. doi: 10.1016/j.jep.2020.113553. [PMID: 33152432]
  • Yrvinn Campos-Vidal, Maribel Herrera-Ruiz, Gabriela Trejo-Tapia, Manases Gonzalez-Cortazar, Antonio Jiménez Aparicio, Alejandro Zamilpa. Gastroprotective activity of kaempferol glycosides from Malvaviscus arboreus Cav. Journal of ethnopharmacology. 2021 Mar; 268(?):113633. doi: 10.1016/j.jep.2020.113633. [PMID: 33253829]
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