(+)-Syringaresinol (BioDeep_00000002747)

Main id: BioDeep_00000017525

 

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


4-[(1S,3aR,4S,6aR)-4-(4-hydroxy-3,5-dimethoxyphenyl)-hexahydrofuro[3,4-c]furan-1-yl]-2,6-dimethoxyphenol

化学式: C22H26O8 (418.1628)
中文名称: (+)-丁香树脂酚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC(=CC(=C1O)OC)C2C3COC(C3CO2)C4=CC(=C(C(=C4)OC)O)OC
InChI: InChI=1S/C22H26O8/c1-25-15-5-11(6-16(26-2)19(15)23)21-13-9-30-22(14(13)10-29-21)12-7-17(27-3)20(24)18(8-12)28-4/h5-8,13-14,21-24H,9-10H2,1-4H3/t13-,14-,21+,22+/m0/s1

描述信息

(+)-syringaresinol is a member of the class of compounds known as furanoid lignans. Furanoid lignans are lignans with a structure that contains either a tetrahydrofuran ring, a furan ring, or a furofuan ring system, that arises from the joining of the two phenylpropanoid units (+)-syringaresinol is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). (+)-syringaresinol can be found in a number of food items such as radish (variety), grape wine, oat, and ginkgo nuts, which makes (+)-syringaresinol a potential biomarker for the consumption of these food products.

同义名列表

12 个代谢物同义名

4-[(1S,3aR,4S,6aR)-4-(4-hydroxy-3,5-dimethoxyphenyl)-hexahydrofuro[3,4-c]furan-1-yl]-2,6-dimethoxyphenol; 4,4-(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(2,6-dimethoxyphenol); syringaresinol, (1alpha,3aalpha, 4alpha,6aalpha)-(+-)-isomer; syringaresinol, (1R-(1alpha, 3aalpha,4alpha,6aalpha))-isomer; Syringaresinol, (+)-; (±)-Syringaresinol; (+)-Syringaresinol; (+)-lirioresinol B; DL-Syringaresinol; syringa-resinol; syringaresinol; (+)-Syringaresinol



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

462 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 CA1, CASP1, GSDMD, NFKB1, NLRP3, NTRK2, PIK3CA, PPARG, PTGS2, SIRT1, TLR4
Peripheral membrane protein 2 GBA1, PTGS2
Endosome membrane 2 NTRK2, TLR4
Endoplasmic reticulum membrane 1 PTGS2
Mitochondrion membrane 1 GSDMD
Nucleus 6 FOSB, NFKB1, NLRP3, PCNA, PPARG, SIRT1
cytosol 10 CA1, CASP1, FOSB, GSDMD, NFKB1, NLRP3, NTRK2, PIK3CA, PPARG, SIRT1
dendrite 1 NTRK2
mitochondrial membrane 1 GSDMD
nuclear body 1 PCNA
trans-Golgi network 1 GBA1
centrosome 1 PCNA
nucleoplasm 6 FOSB, GSDMD, NFKB1, PCNA, PPARG, SIRT1
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 6 CASP1, CD86, GSDMD, NTRK2, TLR4, TNF
lamellipodium 1 PIK3CA
Cell projection, axon 1 NTRK2
Early endosome membrane 1 NTRK2
Multi-pass membrane protein 1 GSDMD
Golgi apparatus membrane 1 NLRP3
cell surface 3 CD86, TLR4, TNF
Golgi apparatus 1 GBA1
Golgi membrane 1 NLRP3
lysosomal membrane 2 GAA, GBA1
neuronal cell body 1 TNF
Cytoplasm, cytosol 1 NLRP3
Lysosome 2 GAA, GBA1
plasma membrane 9 CASP1, CD86, GAA, GSDMD, IFNLR1, NTRK2, PIK3CA, TLR4, TNF
terminal bouton 1 NTRK2
Membrane 7 CD86, GAA, GSDMD, IFNLR1, NLRP3, NTRK2, TLR4
axon 2 CCK, NTRK2
caveola 1 PTGS2
extracellular exosome 5 CA1, CD86, GAA, GBA1, PCNA
Lysosome membrane 2 GAA, GBA1
Lumenal side 1 GBA1
endoplasmic reticulum 3 GBA1, NLRP3, PTGS2
extracellular space 4 CCK, GSDMD, IL6, TNF
lysosomal lumen 2 GAA, GBA1
perinuclear region of cytoplasm 4 NTRK2, PIK3CA, PPARG, TLR4
intercalated disc 1 PIK3CA
mitochondrion 3 NFKB1, NLRP3, SIRT1
protein-containing complex 2 CASP1, PTGS2
intracellular membrane-bounded organelle 3 FOSB, GAA, PPARG
Microsome membrane 1 PTGS2
postsynaptic density 1 NTRK2
chromatin silencing complex 1 SIRT1
Single-pass type I membrane protein 4 CD86, IFNLR1, NTRK2, TLR4
Secreted 5 CCK, GAA, GSDMD, IL6, NLRP3
extracellular region 7 CCK, GAA, GSDMD, IL6, NFKB1, NLRP3, TNF
transcription regulator complex 1 NFKB1
centriolar satellite 1 CD86
external side of plasma membrane 3 CD86, TLR4, TNF
dendritic spine 1 NTRK2
nucleolus 2 CASP1, SIRT1
Early endosome 2 NTRK2, TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 NTRK2
heterochromatin 1 SIRT1
Membrane raft 1 TNF
microtubule 1 CASP1
Nucleus, PML body 1 SIRT1
PML body 1 SIRT1
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 2 GSDMD, NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 3 CASP1, GSDMD, NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 2 PTGS2, SIRT1
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 3 NTRK2, PPARG, TLR4
neuron projection 1 PTGS2
chromatin 5 FOSB, NFKB1, PCNA, PPARG, SIRT1
phagocytic cup 2 TLR4, TNF
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
Endomembrane system 2 GSDMD, NLRP3
microtubule organizing center 1 NLRP3
Cell projection, dendrite 1 NTRK2
tertiary granule membrane 1 GAA
euchromatin 1 SIRT1
replication fork 1 PCNA
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 GSDMD
secretory granule lumen 1 NFKB1
endoplasmic reticulum lumen 2 IL6, PTGS2
male germ cell nucleus 1 PCNA
axon terminus 1 NTRK2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 2 GSDMD, NFKB1
tertiary granule lumen 1 GSDMD
azurophil granule membrane 1 GAA
AIM2 inflammasome complex 1 CASP1
nuclear lamina 1 PCNA
ficolin-1-rich granule membrane 1 GAA
canonical inflammasome complex 1 CASP1
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
autolysosome lumen 1 GAA
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
IPAF inflammasome complex 1 CASP1
NLRP1 inflammasome complex 1 CASP1
protease inhibitor complex 1 CASP1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[Gasdermin-D]: Cytoplasm, cytosol 1 GSDMD
[Gasdermin-D, N-terminal]: Cell membrane 1 GSDMD
[Gasdermin-D, N-terminal]: Cytoplasm, cytosol 1 GSDMD
[Gasdermin-D, p13]: Nucleus 1 GSDMD
[Gasdermin-D, C-terminal]: Cytoplasm, cytosol 1 GSDMD
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

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  • Yunhe Liu, Junzhe Wu, Luying Tan, Zhuoqiao Li, Peng Gao, Shanmei He, Qianyun Wang, Daohao Tang, Cuizhu Wang, Fang Wang, Pingya Li, Jinping Liu. (-)-Syringaresinol attenuates ulcerative colitis by improving intestinal epithelial barrier function and inhibiting inflammatory responses. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155292. doi: 10.1016/j.phymed.2023.155292. [PMID: 38190784]
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  • Sijia Zhang, Lei Yang, Dongsheng Hu, Siqi He, Lingzhi Cui, Jiuling Zhao, Yuzhen Zhuo, Lanqiu Zhang, Ximo Wang. Syringaresinol alleviates IgG immune complex induced acute lung injury via activating PPARγ and suppressing pyroptosis. International immunopharmacology. 2023 Nov; 124(Pt B):111071. doi: 10.1016/j.intimp.2023.111071. [PMID: 37857123]
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  • Yuzhen Zhuo, Lei Yang, Dihua Li, Lanqiu Zhang, Qi Zhang, Shukun Zhang, Caixia Li, Lihua Cui, Jian Hao, Jiarui Li, Ximo Wang. Syringaresinol Resisted Sepsis-Induced Acute Lung Injury by Suppressing Pyroptosis Via the Oestrogen Receptor-β Signalling Pathway. Inflammation. 2022 Apr; 45(2):824-837. doi: 10.1007/s10753-021-01587-9. [PMID: 34807349]
  • Lanqiu Zhang, Xiaolin Jiang, Jinlu Zhang, Hejun Gao, Lei Yang, Dihua Li, Qi Zhang, Botao Wang, Lihua Cui, Ximo Wang. (-)-Syringaresinol suppressed LPS-induced microglia activation via downregulation of NF-κB p65 signaling and interaction with ERβ. International immunopharmacology. 2021 Oct; 99(?):107986. doi: 10.1016/j.intimp.2021.107986. [PMID: 34303280]
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