Lupeol acetate (BioDeep_00000264679)

Main id: BioDeep_00000000689

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Acetic acid (1R,3aR,4S,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropenyl-3a,5a,5b,8,8,11a-hexamethyl-eicosahydro-cyclopenta[a]chrysen-9-yl ester

化学式: C32H52O2 (468.3967)
中文名称: 羽扇豆醇乙酸酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1[C@@H](C([C@H]2[C@](C1)([C@@H]1[C@@](CC2)([C@]2([C@H](CC1)[C@@H]1[C@](CC2)(C)CC[C@H]1C(=C)C)C)C)C)(C)C)OC(=O)C
InChI: InChI=1S/C32H52O2/c1-20(2)22-12-15-29(6)18-19-31(8)23(27(22)29)10-11-25-30(7)16-14-26(34-21(3)33)28(4,5)24(30)13-17-32(25,31)9/h22-27H,1,10-19H2,2-9H3/t22-,23+,24-,25+,26-,27+,29+,30-,31+,32+/m0/s1

描述信息

Lupeol acetate, a derivative of Lupeol, suppresses the progression of rheumatoid arthritis (RA) by inhibiting the activation of macrophages and osteoclastogenesis through downregulations of TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B[1].
Lupeol acetate, a derivative of Lupeol, suppresses the progression of rheumatoid arthritis (RA) by inhibiting the activation of macrophages and osteoclastogenesis through downregulations of TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B[1].

同义名列表

13 个代谢物同义名

Acetic acid (1R,3aR,4S,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropenyl-3a,5a,5b,8,8,11a-hexamethyl-eicosahydro-cyclopenta[a]chrysen-9-yl ester; Lup-20(29)-en-3-ol, acetate, (3beta)-; Lup-20(29)-en-3beta-ol, acetate (8CI); EINECS 216-575-8; Lupeol acetate; 3-acetyllupeol; LMPR01060014; AIDS-076591; AIDS076591; NSC 281806; 1617-68-1; C08630; Lupeol acetate



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

608 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 GLA, PLA2G12A, PTGS2, SLC2A2, TFDP3, TYR, VEGFA
Peripheral membrane protein 2 ACHE, PTGS2
Endoplasmic reticulum membrane 3 GLA, PTGS2, RAC2
Nucleus 5 ACHE, CETN2, MPO, TFDP3, VEGFA
cytosol 3 ACP5, CETN2, RAC2
centrosome 1 CETN2
nucleoplasm 3 CETN2, MPO, PRODH
Cell membrane 3 ACHE, SLC2A2, TNF
lamellipodium 1 RAC2
Multi-pass membrane protein 1 SLC2A2
Synapse 1 ACHE
cell surface 3 ACHE, TNF, VEGFA
Golgi apparatus 3 ACHE, GLA, VEGFA
Golgi membrane 1 INS
lysosomal membrane 1 GAA
mitochondrial inner membrane 1 PRODH
neuromuscular junction 1 ACHE
neuronal cell body 1 TNF
Lysosome 5 ACP5, GAA, GLA, MPO, TYR
plasma membrane 7 ACHE, BCHE, GAA, KNG1, RAC2, SLC2A2, TNF
Membrane 6 ACHE, ACP5, GAA, GLA, SLC2A2, VEGFA
apical plasma membrane 1 SLC2A2
brush border 1 SLC2A2
caveola 1 PTGS2
extracellular exosome 5 GAA, GLA, KNG1, MPO, RAC2
Lysosome membrane 1 GAA
endoplasmic reticulum 2 PTGS2, VEGFA
extracellular space 9 ACHE, BCHE, IL10, IL2, INS, KNG1, MPO, TNF, VEGFA
lysosomal lumen 2 GAA, GLA
perinuclear region of cytoplasm 2 ACHE, TYR
adherens junction 1 VEGFA
mitochondrion 1 PRODH
protein-containing complex 1 PTGS2
intracellular membrane-bounded organelle 4 GAA, MPO, PRODH, TYR
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 1 TYR
Secreted 8 ACHE, BCHE, GAA, IL10, IL2, INS, PLA2G12A, VEGFA
extracellular region 12 ACHE, BCHE, GAA, GLA, IL10, IL2, INS, KNG1, MPO, PLA2G12A, TNF, VEGFA
mitochondrial outer membrane 1 RAC2
mitochondrial matrix 1 PRODH
Extracellular side 1 ACHE
transcription regulator complex 1 TFDP3
photoreceptor connecting cilium 1 CETN2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CETN2
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
Melanosome membrane 1 TYR
apical part of cell 1 CETN2
cell-cell junction 1 SLC2A2
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
focal adhesion 1 RAC2
extracellular matrix 1 VEGFA
basement membrane 1 ACHE
collagen-containing extracellular matrix 1 KNG1
secretory granule 2 MPO, VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 CETN2
chromatin 1 TFDP3
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 RAC2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole 1 CETN2
centriole 1 CETN2
Secreted, extracellular space 1 KNG1
blood microparticle 2 BCHE, KNG1
Lipid-anchor, GPI-anchor 1 ACHE
Nucleus, nuclear pore complex 1 CETN2
nuclear envelope 1 RAC2
Nucleus envelope 1 CETN2
endosome lumen 1 INS
tertiary granule membrane 1 GAA
Melanosome 1 TYR
side of membrane 1 ACHE
azurophil granule 1 MPO
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 BCHE, INS, KNG1, PTGS2
platelet alpha granule lumen 2 KNG1, VEGFA
transport vesicle 1 INS
azurophil granule membrane 1 GAA
azurophil granule lumen 2 GLA, MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GLA, INS
9+2 motile cilium 1 CETN2
nuclear envelope lumen 1 BCHE
phagocytic vesicle lumen 1 MPO
endoplasmic reticulum-Golgi intermediate compartment 1 GLA
nuclear pore nuclear basket 1 CETN2
transcription export complex 2 1 CETN2
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
NADPH oxidase complex 1 RAC2
autolysosome lumen 1 GAA
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
XPC complex 1 CETN2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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