Isoliquiritigenin (BioDeep_00000000063)

 

Secondary id: BioDeep_00000400506

human metabolite PANOMIX_OTCML-2023 natural product Volatile Flavor Compounds


代谢物信息卡片


(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

化学式: C15H12O4 (256.0735552)
中文名称: 异甘草素
谱图信息: 最多检出来源 Viridiplantae(plant) 0.51%

Reviewed

Last reviewed on 2024-09-04.

Cite this Page

Isoliquiritigenin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/isoliquiritigenin (retrieved 2024-11-21) (BioDeep RN: BioDeep_00000000063). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1(O)=CC=C(C(=O)/C=C/C2C=CC(O)=CC=2)C(O)=C1
InChI: InChI=1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+

描述信息

Isoliquiritigenin is a member of the class of chalcones that is trans-chalcone hydroxylated at C-2, -4 and -4. It has a role as an EC 1.14.18.1 (tyrosinase) inhibitor, a biological pigment, a NMDA receptor antagonist, a GABA modulator, a metabolite, an antineoplastic agent and a geroprotector. It is functionally related to a trans-chalcone. It is a conjugate acid of an isoliquiritigenin(1-).
Isoliquiritigenin is a precursor to several flavonones in many plants.
Isoliquiritigenin is a natural product found in Pterocarpus indicus, Dracaena draco, and other organisms with data available.
See also: Glycyrrhiza Glabra (part of); Glycyrrhiza uralensis Root (part of); Pterocarpus marsupium wood (part of).
Isolated from Medicago subspecies Isoliquiritigenin is found in many foods, some of which are cocoa bean, purple mangosteen, blackcurrant, and chives.
A member of the class of chalcones that is trans-chalcone hydroxylated at C-2, -4 and -4.
Isoliquiritigenin is found in pulses. Isoliquiritigenin is isolated from Medicago specie
D004791 - Enzyme Inhibitors
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.

同义名列表

53 个代谢物同义名

InChI=1/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3; 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-; (E)-1-[2,4-bis(oxidanyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one; 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-, (E)-; (2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one; (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propene-1-one; (2E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one; (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one; (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one; 2-PROPEN-1-ONE, 1-(2,4-DIHYDROXYPHENYL)-3-(4-HYDROXYPHENYL)-; 1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-prop-2-en-1-one; (E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-propenone; 1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one; 1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one; 1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-propenone; Acrylophenone, 2,4-dihydroxy-3-(p-hydroxyphenyl)-; 2,4-Dihydroxy-3-(p-hydroxyphenyl)-Acrylophenone; 1-08-00-00707 (Beilstein Handbook Reference); Isoliquiritigenin, analytical standard; 2,4-dihydroxy-4-hydroxychalcone; trans-2,4,4-trihydroxychalcone; Chalcone, 2,4,4-trihydroxy-; 2,4,4-Trihydroxy-Chalcone; TRIHYDROXYCHALCONE [INCI]; Isoliquiritigenin, powder; 2,4,4-trihydroxychalcone; 4,2,4-Trihydroxychalcone; 2,4,4-Trihydroxychalcone; 424-trihydroxychalcone; iso-Liquiritigenin; Trihydroxychalcone; Isoliquiritigenin; Spectrum5_000612; 6-deoxychalcone; UNII-B9CTI9GB8F; Isoliquiritigen; Lopac0_000681; MEGxp0_001326; ACon1_000047; CMLD3_000056; Tox21_500681; B9CTI9GB8F; C15H12O4; GU-17; GU 17; ILTG; ISLQ; GU17; ILG; GU17;ISL;Isoliquiritigen; ISL; SJ000286237; Isoliquiritigenin



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

368 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(6)

WikiPathways(0)

Plant Reactome(220)

INOH(0)

PlantCyc(141)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

261 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shiwen Peng, Fangling Shu, Yanhui Lu, Dongsheng Fan, Dehong Zheng, Gaoqing Yuan. Quasi-targeted metabolomics revealed isoliquiritigenin and lauric acid associated with resistance to tobacco black shank. Plant signaling & behavior. 2024 Dec; 19(1):2332019. doi: 10.1080/15592324.2024.2332019. [PMID: 38527068]
  • Peijun Sun, Huixian Chen, Xiaoyu Fan, Jiayi Wang, Lujie Lu, Guangchao Yang, Jining Liu, Weifeng Yao, Feng Ding, Jie Ding, Jianmei Liu, Tulin Lu, Lihong Chen. Exploring the effective components of honey-processed licorice (Glycyrrhiza uralensis Fisch.) in attenuating Doxorubicin-induced myocardial cytotoxicity by combining network pharmacology and in vitro experiments. Journal of ethnopharmacology. 2024 Jul; 329(?):118178. doi: 10.1016/j.jep.2024.118178. [PMID: 38604511]
  • Jingjing Shi, Ke Zhang, Ting Li, Lijuan Wu, Yang Yang, Yuan Zhang, Pengfei Tu, Wenjing Liu, Yuelin Song. Differentiation of isomeric chalcone and dihydroflavone using liquid chromatography coupled with hydrogen-deuterium exchange tandem mass spectrometry (HDX-MS/MS): An application for flavonoids-focused characterization of Snow chrysanthemum. Journal of chromatography. A. 2024 Apr; 1720(?):464773. doi: 10.1016/j.chroma.2024.464773. [PMID: 38432106]
  • Xiang Xiao, Duoyong Lang, Jingjiao Yong, Xinhui Zhang. Bacillus cereus G2 alleviate salt stress in Glycyrrhiza uralensis Fisch. by balancing the downstream branches of phenylpropanoids and activating flavonoid biosynthesis. Ecotoxicology and environmental safety. 2024 Mar; 273(?):116129. doi: 10.1016/j.ecoenv.2024.116129. [PMID: 38430580]
  • Wenjie He, Ying Sun, Sai Zhang, Jiawen Li, Jixing Feng, Yun Yang, Hui Meng, Zheng Zhang. Correlation between Colour Traits and Intrinsic Quality of Dalbergiae Odoriferae Lignum. Molecules (Basel, Switzerland). 2023 Nov; 28(22):. doi: 10.3390/molecules28227635. [PMID: 38005357]
  • Kun Ren, Xuanmeng Zhang, Ruijie Wang, Shumeng Ren, Huiming Hua, Dongmei Wang, Yingni Pan, Xiaoqiu Liu. The inhibitory effect of licorice on the hepatotoxicity induced by the metabolic activation of Euodiae Fructus. Journal of ethnopharmacology. 2023 Oct; 319(Pt 2):117233. doi: 10.1016/j.jep.2023.117233. [PMID: 37793580]
  • Dennis Jine Yuan Hsieh, Md Nazmul Islam, Wei-Wen Kuo, Marthandam Asokan Shibu, Chin-Hu Lai, Pi-Yu Lin, Shinn-Zong Lin, Michael Yu-Chih Chen, Chih-Yang Huang. A combination of isoliquiritigenin with Artemisia argyi and Ohwia caudata water extracts attenuates oxidative stress, inflammation, and apoptosis by modulating Nrf2/Ho-1 signaling pathways in SD rats with doxorubicin-induced acute cardiotoxicity. Environmental toxicology. 2023 Sep; ?(?):. doi: 10.1002/tox.23936. [PMID: 37661764]
  • Mingzhu Yu, Qiaoling Pan, Wenbiao Li, Tingting Du, Fei Huang, Hui Wu, Yixin He, Xiaojun Wu, Hailian Shi. Isoliquiritigenin inhibits gastric cancer growth through suppressing GLUT4 mediated glucose uptake and inducing PDHK1/PGC-1α mediated energy metabolic collapse. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 121(?):155045. doi: 10.1016/j.phymed.2023.155045. [PMID: 37742526]
  • Ziyi Chen, Wenwen Ding, Xiaoxue Yang, Tiangong Lu, Ying Liu. Isoliquiritigenin, a potential therapeutic agent for treatment of inflammation-associated diseases. Journal of ethnopharmacology. 2023 Aug; 318(Pt B):117059. doi: 10.1016/j.jep.2023.117059. [PMID: 37604329]
  • Yi Hu, Peiyi Liang, Zhuxian Wang, CuiPing Jiang, Quanfu Zeng, Chunyan Shen, Yufan Wu, Li Liu, Yankui Yi, Hongxia Zhu, Qiang Liu. Exploring the mechanism of solubilization and release of isoliquiritigenin in deep eutectic solvents. International journal of pharmaceutics. 2023 Aug; ?(?):123298. doi: 10.1016/j.ijpharm.2023.123298. [PMID: 37558146]
  • Zeyu Wang, Weijian Li, Xue Wang, Qin Zhu, Liguo Liu, Shimei Qiu, Lu Zou, Ke Liu, Guoqiang Li, Huijie Miao, Yang Yang, Chengkai Jiang, Yong Liu, Rong Shao, Xu'an Wang, Yingbin Liu. Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells. Chinese medical journal. 2023 Jul; ?(?):. doi: 10.1097/cm9.0000000000002675. [PMID: 37488674]
  • Lei Ye, Ming Su, Xinyi Qiao, Shaowei Wang, Ke Zheng, Yang Zhu, Huitao Li, Yiyan Wang, Ren-Shan Ge. Chalcone derivatives from licorice inhibit human and rat gonadal 3β-hydroxysteroid dehydrogenases as therapeutic uses. Journal of ethnopharmacology. 2023 May; ?(?):116690. doi: 10.1016/j.jep.2023.116690. [PMID: 37245711]
  • Vineet Babu, Deepak Singh Kapkoti, Monika Binwal, Rajendra S Bhakuni, Karuna Shanker, Manju Singh, Sudeep Tandon, Madhav N Mugale, Narendra Kumar, Dnyaneshwar U Bawankule. Liquiritigenin, isoliquiritigenin rich extract of glycyrrhiza glabra roots attenuates inflammation in macrophages and collagen-induced arthritis in rats. Inflammopharmacology. 2023 Mar; ?(?):. doi: 10.1007/s10787-023-01152-w. [PMID: 36947299]
  • Na Liu, Min Liu, Mengwei Jiang, Zhenwei Li, Weijun Chen, Wenxuan Wang, Xianglei Fu, Man Qi, Md Hasan Ali, Nan Zou, Qingguang Liu, Hui Tang, Shenghui Chu. Isoliquiritigenin alleviates the development of alcoholic liver fibrosis by inhibiting ANXA2. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Mar; 159(?):114173. doi: 10.1016/j.biopha.2022.114173. [PMID: 36680814]
  • Jianyu He, Ying Deng, Lingxuan Ren, Zhen Jin, Jianjun Yang, Feng Yao, Yizhen Liu, Zihan Zheng, Danli Chen, Bo Wang, Yirong Zhang, Guanjun Nan, Weirong Wang, Rong Lin. Isoliquiritigenin from licorice flavonoids attenuates NLRP3-mediated pyroptosis by SIRT6 in vascular endothelial cells. Journal of ethnopharmacology. 2023 Mar; 303(?):115952. doi: 10.1016/j.jep.2022.115952. [PMID: 36442759]
  • Queen Saikia, Ajit Hazarika, Jogen Chandra Kalita. Isoliquiritigenin ameliorates paroxetine-induced sexual dysfunction in male albino mice. Reproductive toxicology (Elmsford, N.Y.). 2023 Feb; 117(?):108341. doi: 10.1016/j.reprotox.2023.108341. [PMID: 36740106]
  • Xiancong Zeng, Mengxia Zhao, Hefeng Yao. Anti-lung Cancer, Anti-microbial, Anti-α-glucosidase, Anti-sorbitol Dehydrogenase, and in silico Studies of Wogonoside and Isoliquiritigenin as Natural Compounds. Journal of oleo science. 2023; 72(10):919-927. doi: 10.5650/jos.ess23101. [PMID: 37793822]
  • Yuyan Bai, Jin Zhou, Han Zhu, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu. Isoliquiritigenin inhibits microglia-mediated neuroinflammation in models of Parkinson's disease via JNK/AKT/NFκB signaling pathway. Phytotherapy research : PTR. 2022 Dec; ?(?):. doi: 10.1002/ptr.7665. [PMID: 36484427]
  • Boran Ni, Yi Liu, Xue Gao, Mengru Cai, Jing Fu, Xingbin Yin, Jian Ni, Xiaoxv Dong. Isoliquiritigenin attenuates emodin-induced hepatotoxicity in vivo and in vitro through Nrf2 pathway. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Nov; 261(?):109430. doi: 10.1016/j.cbpc.2022.109430. [PMID: 35944824]
  • Zhu Zhang, Wen-Qing Chen, Shi-Qing Zhang, Jing-Xuan Bai, Bin Liu, Ken Kin-Lam Yung, Joshua Ka-Shun Ko. Isoliquiritigenin inhibits pancreatic cancer progression through blockade of p38 MAPK-regulated autophagy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154406. doi: 10.1016/j.phymed.2022.154406. [PMID: 36029643]
  • Yameng Cui, Yulin Wu, Cong Wang, Zuolin Wang, Yanyang Li, Zhansheng Jiang, Wei Zhao, Zhanyu Pan. Isoliquiritigenin inhibits non-small cell lung cancer progression via m6A/IGF2BP3-dependent TWIST1 mRNA stabilization. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Sep; 104(?):154299. doi: 10.1016/j.phymed.2022.154299. [PMID: 35816995]
  • Manman Li, Guicong Lu, Xiao Ma, Ruihong Wang, Xihong Chen, Yongxiong Yu, Caode Jiang. Anti-inflammation of isoliquiritigenin via the inhibition of NF-κB and MAPK in LPS-stimulated MAC-T cells. BMC veterinary research. 2022 Aug; 18(1):320. doi: 10.1186/s12917-022-03414-1. [PMID: 35986317]
  • Jinxia Sun, Qingwen Zhang, Guizhen Yang, Yinhong Li, Yan Fu, Yuejuan Zheng, Xin Jiang. The licorice flavonoid isoliquiritigenin attenuates Mycobacterium tuberculosis-induced inflammation through Notch1/NF-κB and MAPK signaling pathways. Journal of ethnopharmacology. 2022 Aug; 294(?):115368. doi: 10.1016/j.jep.2022.115368. [PMID: 35589023]
  • Meiling Gao, Qiang Cai, Haichao Si, Si Shi, Huixia Wei, Miaomiao Lv, Xiaofan Wang, Tieli Dong. Isoliquiritigenin attenuates pathological cardiac hypertrophy via regulating AMPKα in vivo and in vitro. Journal of molecular histology. 2022 Aug; 53(4):679-689. doi: 10.1007/s10735-022-10090-w. [PMID: 35834120]
  • Chin-Yi Lin, Yu-Cheng Lin, Catherine Reena Paul, Dennis Jine-Yuan Hsieh, Cecilia Hsuan Day, Ray-Jade Chen, Chia-Hua Kuo, Tsung-Jung Ho, Marthandam Asokan Shibu, Chin-Hu Lai, Tzu-Ching Shih, Wei-Wen Kuo, Chih-Yang Huang. Isoliquiritigenin ameliorates advanced glycation end-products toxicity on renal proximal tubular epithelial cells. Environmental toxicology. 2022 Aug; 37(8):2096-2102. doi: 10.1002/tox.23553. [PMID: 35583127]
  • Sha Huang, Yuhua Wang, Shuwen Xie, Yuqi Lai, Chan Mo, Ting Zeng, Shanshan Kuang, Chuying Zhou, Zhiyun Zeng, Yuyao Chen, Shaohui Huang, Lei Gao, Zhiping Lv. Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 101(?):154117. doi: 10.1016/j.phymed.2022.154117. [PMID: 35489326]
  • Kaitlyn M Joyce, Carmen P Wong, Ian A Scriven, Dawn A Olson, Daniel R Doerge, Adam J Branscum, Lara H Sattgast, William G Helferich, Russell T Turner, Urszula T Iwaniec. Isoliquiritigenin Decreases Bone Resorption and Osteoclast Differentiation. Molecular nutrition & food research. 2022 06; 66(11):e2100974. doi: 10.1002/mnfr.202100974. [PMID: 35319818]
  • Zhengyang Li, Chao Xu, Yan Wang. Poly d,l-(lactic-co-glycolic) Acid PEGylated Isoliquiritigenin Alleviates Traumatic Brain Injury by Reversing Cyclooxygenase 2 Level. Journal of biomedical nanotechnology. 2022 Mar; 18(3):909-916. doi: 10.1166/jbn.2022.3284. [PMID: 35715911]
  • Lu Wang, Xiaohui Wang, Lina Kong, Yingying Li, Kai Huang, Jingjing Wu, Changyuan Wang, Huijun Sun, Pengyuan Sun, Jiangning Gu, Haifeng Luo, Kexin Liu, Qiang Meng. Activation of PGC-1α via isoliquiritigenin-induced downregulation of miR-138-5p alleviates nonalcoholic fatty liver disease. Phytotherapy research : PTR. 2022 Feb; 36(2):899-913. doi: 10.1002/ptr.7334. [PMID: 35041255]
  • Lu Wang, Lina Kong, Shuai Xu, Xiaohui Wang, Kai Huang, Shuyuan Wang, Jingjing Wu, Changyuan Wang, Huijun Sun, Kexin Liu, Qiang Meng. Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Feb; 96(?):153845. doi: 10.1016/j.phymed.2021.153845. [PMID: 34785106]
  • Wahidah H Al-Qahtani, Ghedeir M Alshammari, Jamaan S Ajarem, Amani Y Al-Zahrani, Aishah Alzuwaydi, Refaat Eid, Mohammed Abdo Yahya. Isoliquiritigenin prevents Doxorubicin-induced hepatic damage in rats by upregulating and activating SIRT1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Feb; 146(?):112594. doi: 10.1016/j.biopha.2021.112594. [PMID: 34968927]
  • Chen Xing, Wen-Qiang Cui, Yue Zhang, Xin-Shu Zou, Jing-You Hao, Si-Di Zheng, Ting-Ting Wang, Xiao-Zhen Wang, Tong Wu, Yan-Yan Liu, Xue-Ying Chen, Shu-Guang Yuan, Zhi-Yun Zhang, Yan-Hua Li. Ultrasound-assisted deep eutectic solvents extraction of glabridin and isoliquiritigenin from Glycyrrhiza glabra: Optimization, extraction mechanism and in vitro bioactivities. Ultrasonics sonochemistry. 2022 Feb; 83(?):105946. doi: 10.1016/j.ultsonch.2022.105946. [PMID: 35151194]
  • Tan Rui-Zhi, Xie Ke-Huan, Liao Yuan, Lin Xiao, Zhu Bing-Wen, Liu Tong-Tong, Wang Li. Renoprotective effect of isoliquiritigenin on cisplatin-induced acute kidney injury through inhibition of FPR2 in macrophage. Journal of pharmacological sciences. 2022 Jan; 148(1):56-64. doi: 10.1016/j.jphs.2021.10.001. [PMID: 34924130]
  • Leiming Sun, Zheng Yang, Jiaying Zhang, Jie Wang. Isoliquiritigenin attenuates acute renal injury through suppressing oxidative stress, fibrosis and JAK2/STAT3 pathway in streptozotocin-induced diabetic rats. Bioengineered. 2021 12; 12(2):11188-11200. doi: 10.1080/21655979.2021.2006978. [PMID: 34784849]
  • Yun Tang, Haojun Luo, Qiong Xiao, Li Li, Xiang Zhong, Jiong Zhang, Fang Wang, Guisen Li, Li Wang, Yi Li. Isoliquiritigenin attenuates septic acute kidney injury by regulating ferritinophagy-mediated ferroptosis. Renal failure. 2021 Dec; 43(1):1551-1560. doi: 10.1080/0886022x.2021.2003208. [PMID: 34791966]
  • Tzu-Yu Lin, Cheng-Wei Lu, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang. Natural Product Isoliquiritigenin Activates GABAB Receptors to Decrease Voltage-Gate Ca2+ Channels and Glutamate Release in Rat Cerebrocortical Nerve Terminals. Biomolecules. 2021 10; 11(10):. doi: 10.3390/biom11101537. [PMID: 34680170]
  • Min Hye Kang, Gwi Yeong Jang, Yun-Jeong Ji, Jeong Hoon Lee, Su Ji Choi, Tae Kyung Hyun, Hyung Don Kim. Antioxidant and Anti-Melanogenic Activities of Heat-Treated Licorice (Wongam, Glycyrrhiza glabra × G. uralensis) Extract. Current issues in molecular biology. 2021 Sep; 43(2):1171-1187. doi: 10.3390/cimb43020083. [PMID: 34563052]
  • Junjie Yang, Fanjie Hu, Chengjun Guo, Yuqing Liang, Haiying Song, Kui Cheng. Discovery of isoliquiritigenin analogues that reverse acute hepatitis by inhibiting macrophage polarization. Bioorganic chemistry. 2021 09; 114(?):105043. doi: 10.1016/j.bioorg.2021.105043. [PMID: 34120019]
  • Li Zhang, Sheng-Ye Yang, Feng-Rong Qi-Li, Xiao-Xiao Liu, Wei-Tao Zhang, Chao Peng, Ping Wu, Ping Li, Pingping Li, Xiaojun Xu. Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2-CREB-SIRT1 axis. Phytotherapy research : PTR. 2021 Jul; 35(7):3898-3915. doi: 10.1002/ptr.7101. [PMID: 33860590]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ankur Kumar Tanwar, Neha Dhiman, Amit Kumar, Vikas Jaitak. Engagement of phytoestrogens in breast cancer suppression: Structural classification and mechanistic approach. European journal of medicinal chemistry. 2021 Mar; 213(?):113037. doi: 10.1016/j.ejmech.2020.113037. [PMID: 33257172]
  • Sharifa Alzahrani, Eman Said, Sadeem M Ajwah, Sumayyah Y Alsharif, Khaled S El-Bayoumi, Sawsan A Zaitone, Mona Qushawy, Nehal M Elsherbiny. Isoliquiritigenin attenuates inflammation and modulates Nrf2/caspase-3 signalling in STZ-induced aortic injury. The Journal of pharmacy and pharmacology. 2021 Mar; 73(2):193-205. doi: 10.1093/jpp/rgaa056. [PMID: 33793806]
  • Jing Wu, Qiao-Qiao Zhong, Tian-Yun Wang, Chen-Xiang Wang, Yan Du, Shuai Ji, Liang Wang, Meng-Zhe Guo, Dao-Quan Tang. MS-based metabolite analysis of two licorice chalcones in mice plasma, bile, feces, and urine after oral administration. Biomedical chromatography : BMC. 2021 Mar; 35(3):e4998. doi: 10.1002/bmc.4998. [PMID: 33037660]
  • Fu Peng, Hailin Tang, Junrong Du, Jianping Chen, Cheng Peng. Isoliquiritigenin Suppresses EMT-Induced Metastasis in Triple-Negative Breast Cancer through miR-200c/C-JUN/[Formula: see text]-Catenin. The American journal of Chinese medicine. 2021; 49(2):505-523. doi: 10.1142/s0192415x21500233. [PMID: 33641651]
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