Hesperidin (BioDeep_00000000354)

 

Secondary id: BioDeep_00000270276, BioDeep_00000344407, BioDeep_00000866218

natural product human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)chroman-4-one

化学式: C28H34O15 (610.1897614000001)
中文名称: 二氢黄酮甙, 橙皮苷, 橙皮甙, 橙皮甙
谱图信息: 最多检出来源 Viridiplantae(plant) 0.41%

分子结构信息

SMILES: c1(cc(c2c(c1)O[C@@H](CC2=O)c1cc(c(cc1)OC)O)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@@H](O1)CO[C@@H]1O[C@H]([C@@H]([C@H]([C@@H]1O)O)O)C)O)O)O
InChI: InChI=1/C28H34O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-7,10,17,19,21-30,32-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1

描述信息

Hesperidin is an abundant and inexpensive by-product of Citrus cultivation and is the major flavonoid in sweet orange and lemon. In young immature oranges it can account for up to 14\\\\% of the fresh weight of the fruit. Hesperidin is an abundant and inexpensive by-product of Citrus cultivation and is the major flavonoid in sweet orange and lemon. In young immature oranges it can account for up to 14\\\\% of the fresh weight of the fruit due to vitamin C deficiency such as bruising due to capillary fragility were found in early studies to be relieved by crude vitamin C extract but not by purified vitamin C. The bioflavonoids, formerly called "vitamin P", were found to be the essential components in correcting this bruising tendency and improving the permeability and integrity of the capillary lining. These bioflavonoids include hesperidin, citrin, rutin, flavones, flavonols, catechin and quercetin. Of historical importance is the observation that "citrin", a mixture of two flavonoids, eriodictyol and hesperidin, was considered to possess a vitamin-like activity, as early as in 1949. Hesperidin deficiency has since been linked with abnormal capillary leakiness as well as pain in the extremities causing aches, weakness and night leg cramps. Supplemental hesperidin also helps in reducing oedema or excess swelling in the legs due to fluid accumulation. As with other bioflavonoids, hesperidin works best when administered concomitantly with vitamin C. No signs of toxicity have been observed with normal intake of hesperidin. Hesperidin was first discovered in 1827, by Lebreton, but not in a pure state and has been under continuous investigation since then (PMID:11746857).
Hesperidin is a disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as a mutagen. It is a disaccharide derivative, a member of 3-hydroxyflavanones, a dihydroxyflavanone, a monomethoxyflavanone, a flavanone glycoside, a member of 4-methoxyflavanones and a rutinoside. It is functionally related to a hesperetin.
Hesperidin is a flavan-on glycoside found in citrus fruits.
Hesperidin is a natural product found in Ficus erecta var. beecheyana, Citrus tankan, and other organisms with data available.
A flavanone glycoside found in CITRUS fruit peels.
See also: Tangerine peel (part of).
Found in most citrus fruits and other members of the Rutaceae, also in Mentha longifolia
Acquisition and generation of the data is financially supported in part by CREST/JST.
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.770
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.767
[Raw Data] CB217_Hesperidin_pos_50eV_CB000076.txt
[Raw Data] CB217_Hesperidin_pos_20eV_CB000076.txt
[Raw Data] CB217_Hesperidin_pos_30eV_CB000076.txt
[Raw Data] CB217_Hesperidin_pos_10eV_CB000076.txt
[Raw Data] CB217_Hesperidin_pos_40eV_CB000076.txt
[Raw Data] CB217_Hesperidin_neg_20eV_000038.txt
[Raw Data] CB217_Hesperidin_neg_50eV_000038.txt
[Raw Data] CB217_Hesperidin_neg_10eV_000038.txt
[Raw Data] CB217_Hesperidin_neg_30eV_000038.txt
[Raw Data] CB217_Hesperidin_neg_40eV_000038.txt
Annotation level-1
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Hesperidin (Hesperetin 7-rutinoside), a flavanone glycoside, is isolated from citrus fruits. Hesperidin has numerous biological properties, such as decreasing inflammatory mediators and exerting significant antioxidant effects. Hesperidin also exhibits antitumor and antiallergic activities[1][2].
Hesperidin (Hesperetin 7-rutinoside), a flavanone glycoside, is isolated from citrus fruits. Hesperidin has numerous biological properties, such as decreasing inflammatory mediators and exerting significant antioxidant effects. Hesperidin also exhibits antitumor and antiallergic activities[1][2].

同义名列表

90 个代谢物同义名

(S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)chroman-4-one; (S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)methyl)tetrahydro-2H-pyran-2-yloxy)chroman-4-one; (2S)-5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-chroman-4-one; (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-3,4-dihydro-2H-1-benzopyran-4-one; (2S)-2-(4-methoxy-3-oxidanyl-phenyl)-7-[(2S,3R,4S,5S,6R)-6-[[(2R,3R,4R,5R,6S)-6-methyl-3,4,5-tris(oxidanyl)oxan-2-yl]oxymethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-oxidanyl-2,3-dihydrochromen-4-one; (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-2-oxanyl]oxymethyl]-2-oxanyl]oxy]-3,4-dihydro-2H-1-benzopyran-4-one; (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-{[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-({[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-3,4-dihydro-2H-1-benzopyran-4-one; (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one; (2S)-5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxymethyl]oxan-2-yl]oxy-chroman-4-one; (2S)-7-[[6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one (Hesperidin); 4H-1-BENZOPYRAN-4-ONE, 7-((6-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2,3-DIHYDO-5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-, (S)-; (2S)-7-((6-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-2,3-DIHYDRO-5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-; (S)-7-[[6-O-(6-Deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-; 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydo-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-; 7-((6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one, (S)-; (2S)-7-((6-O-(6-DEOXY-alpha-L-MANNOPYRANOSYL)-beta-D-GLUCOPYRANOSYL)OXY)-2,3-DIHYDRO-5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; (s)-7-[[6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-one; (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside; 7-(6-O-Desoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyloxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-chromanon; 5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-7-((6-O-.ALPHA.-L-RHAMNOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL)OXY)-4-CHROMANON; 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((6-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranosyl)oxy)-4-chromanon; Flavanone, 3,5,7-trihydroxy-4-methoxy-, 7-(6-O-alpha-L-rhamnosyl-delta-glucoside) (7ci); Flavanone, 3,5,7-trihydroxy-4-methoxy-, 7-(6-O-a-L-rhamnosyl-D-glucoside) (7ci); Flavanone, 3,5,7-trihydroxy-4-methoxy-, 7-(6-O-alpha-L-rhamnosyl-D-glucoside); Glucopyranoside, hesperetin-7 6-O-(6-deoxy-alpha-L-mannopyranosyl)-, beta-D-; Hesperidin, Pharmaceutical Secondary Standard; Certified Reference Material; Hesperetin, 7-(6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside); hesperetin 7-(6-O-alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside; Hesperidin, European Pharmacopoeia (EP) Reference Standard; Hesperidin, primary pharmaceutical reference standard; methyltetrahydro-2H-pyran-2-yloxy)methyl)tetrahydro-; 3,5-DIHYDROXY-4-METHOXY-7-RUTINOSYLOXYFLAVAN-4-ONE; 3,5-Dihydroxy-4-methoxy-7-rutinosyloxyflavan-4-on; 5-18-05-00218 (Beilstein Handbook Reference); (S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-; 7-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-; Hesperetin-1-rhamnosido-D-Glucose; Aurantiamarin (Methyl Hesperidin); Hesperidin, analytical standard; 2H-pyran-2-yloxy)chroman-4-one; Hesperetin-7-O-rhamnoglucoside; 7-Rhamnoglucoside, Hesperetin; Hesperetin 7 Rhamnoglucoside; Hesperitin-7-rhamnoglucoside; hesperetin 7-rhamnoglucoside; QUQPHWDTPGMPEX-QJBIFVCTSA-N; Hesperetin 7-O-rutinoside; Hesperetin 7-rutinoside; Hesperetin 7 Rutinoside; Hesperetin-7-rutinoside; Hesperetin-rutinoside; Hesperidin, (S)-(-)-; Hesperetin Glycoside; Hesperetin-rutinosid; HESPERIDIN (USP-RS); HESPERIDIN [USP-RS]; HESPERIDIN [WHO-DD]; Hesperidin, >=80\\%; HESPERIDIN [MART.]; HESPERIDIN [VANDF]; (S)-(-)-Hesperidin; HESPERIDIN (MART.); HESPERIDIN [INCI]; Hesperidin, (2S)-; Prestwick3_000400; Hesperidin (JAN); HESPERIDIN [JAN]; BCBcMAP01_000136; HESPERIDIN [MI]; (2S)-Hesperidin; 2S, Hesperidin; Hesperidin,(S); BPBio1_000681; Hesperidin 2S; Hesper bitabs; Atripliside b; DIOSMIN [NDI]; Hesperidoside; Tox21_110448; Hesperidine; Hesperidina; SMP1_000149; Hesperidin; Hesperiden; USAF CF-3; DIOSVEIN; Cirantin; Ciratin



数据库引用编号

58 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(1)

代谢反应

10 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(9)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

175 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hong Zhuang, Xiaoliang Zhang, Sijia Wu, Chen Mao, Yaxi Dai, Pang Yong, Xiaodi Niu. Study transport of hesperidin based on the DPPC lipid model and the BSA transport model. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2024 Jun; 314(?):124172. doi: 10.1016/j.saa.2024.124172. [PMID: 38513316]
  • Umar Muazu Yunusa, Raziye Ozturk Urek. Phenolic composition, antioxidant, and cytotoxic effects on HeLa and HepG2 cancer cell lines of Mespilus germanica grown in Turkey. Natural product research. 2024 Jun; 38(11):1972-1976. doi: 10.1080/14786419.2023.2230612. [PMID: 37395516]
  • Hanumanthappa Shylaja, Gollapalle Lakshminarayanashastry Viswanatha, Venkategowda Sunil, Shalam M Hussain, Syeda Ayesha Farhana. Effect of hesperidin on blood pressure and lipid profile: A systematic review and meta-analysis of randomized controlled trials. Phytotherapy research : PTR. 2024 May; 38(5):2560-2571. doi: 10.1002/ptr.8174. [PMID: 38462779]
  • Mazhar Hussain, Arslan Hafeez, Muhammad Rizwan, Rizwan Rasheed, Mahmoud F Seleiman, Muhammad Arslan Ashraf, Shafaqat Ali, Umer Farooq, Muhammad Nafees. Pervasive influence of heavy metals on metabolic pathways is potentially relieved by hesperidin to enhance the phytoremediation efficiency of Bassia scoparia. Environmental science and pollution research international. 2024 May; 31(23):34526-34549. doi: 10.1007/s11356-024-33530-4. [PMID: 38709411]
  • Katarzyna Stec, Bożena Kordan, Jan Bocianowski, Beata Gabryś. Hesperidin as a Species-Specific Modifier of Aphid Behavior. International journal of molecular sciences. 2024 Apr; 25(9):. doi: 10.3390/ijms25094822. [PMID: 38732039]
  • Álvaro Pérez-Valero, Juan Serna-Diestro, Albert Tafur Rangel, Simona Barbuto Ferraiuolo, Chiara Schiraldi, Eduard J Kerkhoven, Claudio J Villar, Felipe Lombó. Biosynthesis of Hesperetin, Homoeriodictyol, and Homohesperetin in a Transcriptomics-Driven Engineered Strain of Streptomyces albidoflavus. International journal of molecular sciences. 2024 Apr; 25(7):. doi: 10.3390/ijms25074053. [PMID: 38612864]
  • Fevzi Elbasan, Busra Arikan, Ceyda Ozfidan-Konakci, Aysenur Tofan, Evren Yildiztugay. Hesperidin and chlorogenic acid mitigate arsenic-induced oxidative stress via redox regulation, photosystems-related gene expression, and antioxidant efficiency in the chloroplasts of Zea mays. Plant physiology and biochemistry : PPB. 2024 Mar; 208(?):108445. doi: 10.1016/j.plaphy.2024.108445. [PMID: 38402801]
  • Adeola Oluwatosin Adedara, Getúlio Nicola Bressan, Matheus Mulling Dos Santos, Roselei Fachinetto, Amos Olalekan Abolaji, Nilda Vargas Barbosa. Antioxidant responses driven by Hesperetin and Hesperidin counteract Parkinson's disease-like phenotypes in Drosophila melanogaster. Neurotoxicology. 2024 Mar; 101(?):117-127. doi: 10.1016/j.neuro.2024.02.006. [PMID: 38423185]
  • Bin Duan, Yonghua Zhang, Zhao Feng, Zhaoguo Liu, Nengguo Tao. Octanal enhances disease resistance in postharvest citrus fruit by the biosynthesis and metabolism of aromatic amino acids. Pesticide biochemistry and physiology. 2024 Mar; 200(?):105835. doi: 10.1016/j.pestbp.2024.105835. [PMID: 38582597]
  • Mazhar Hussain, Arslan Hafeez, Arwa Abdulkreem Al-Huqail, Ibtisam Mohammed Alsudays, Suliman Mohammed Suliman Alghanem, Muhammad Arslan Ashraf, Rizwan Rasheed, Muhammad Rizwan, Amany H A Abeed. Effect of hesperidin on growth, photosynthesis, antioxidant systems and uptake of cadmium, copper, chromium and zinc by Celosia argentea plants. Plant physiology and biochemistry : PPB. 2024 Feb; 207(?):108433. doi: 10.1016/j.plaphy.2024.108433. [PMID: 38364631]
  • Ruixi Luo, Yudie Hu, La Wang, Wenjia Wang, Ping Wang, Zunli Ke, Didong Lou, Weiyi Tian. Hesperidin Protects Against High-Fat Diet-Induced Lipotoxicity in Rats by Inhibiting Pyroptosis. Journal of medicinal food. 2024 Jan; ?(?):. doi: 10.1089/jmf.2023.k.0259. [PMID: 38294790]
  • Naveed Ullah Khan, Anam Razzaq, Zhang Rui, Xie Chengfeng, Zaheer Ullah Khan, Asmat Ullah, Serag Eldin I Elbehairi, Ali A Shati, Mohammad Y Alfaifi, Haroon Iqbal, Zhi Min Jin. Bio-evaluations of sericin coated hesperidin nanoparticles for gastric ulcer management. Colloids and surfaces. B, Biointerfaces. 2024 Jan; 234(?):113762. doi: 10.1016/j.colsurfb.2024.113762. [PMID: 38244483]
  • Xianbin Yu, Zhixuan Liu, Yitian Yu, Chengjie Qian, Yuzhe Lin, Shuqing Jin, Long Wu, Shi Li. Hesperetin promotes diabetic wound healing by inhibiting ferroptosis through the activation of SIRT3. Phytotherapy research : PTR. 2024 Jan; ?(?):. doi: 10.1002/ptr.8121. [PMID: 38234096]
  • Iman Nabil, Amira Abulfotooh Eid, Hend A Yassin, Rana Ahmed Abouelrous, Amany A Solaiman. Protective role of hesperidin in finasteride-induced testicular toxicity in adult male Wistar rats: Insights into oxidative stress, apoptosis, and ultrastructure of seminiferous tubules. Reproductive toxicology (Elmsford, N.Y.). 2024 Jan; 124(?):108535. doi: 10.1016/j.reprotox.2024.108535. [PMID: 38216069]
  • Tong Nie, Xin Wang, Aqun Li, Anshan Shan, Jun Ma. The promotion of fatty acid β-oxidation by hesperidin via activating SIRT1/PGC1α to improve NAFLD induced by a high-fat diet. Food & function. 2024 Jan; 15(1):372-386. doi: 10.1039/d3fo04348g. [PMID: 38099440]
  • Guangying Wu, Xingqin Wei, Dongmei Li, Guanlin Xiao, Canchao Jia, Zhihao Zeng, Zhao Chen. Selection and evaluation of quality markers for the regulation of PXR-CYP3A4/FXR-LXRα by Exocarpium Citri Grandis for the treatment of hyperlipidaemia with dispelling blood stasis and removing phlegm. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 170(?):116089. doi: 10.1016/j.biopha.2023.116089. [PMID: 38157640]
  • Filiz Ozyigit, Ayse Nur Deger, Fatma Emel Kocak, Mehmet Fatih Ekici, Hasan Simsek, Ozlem Arık. Protective effects of hesperidin in gastric damage caused by experimental ischemia-reperfusion injury model in rats. Acta cirurgica brasileira. 2024; 39(?):e391124. doi: 10.1590/acb391124. [PMID: 38477785]
  • Vedpal Singh, Rohit Singh, Manish Pal Singh, Archita Katrolia. Therapeutic Role of Desmodium Species on its Isolated Flavonoids. Current molecular medicine. 2024; 24(1):74-84. doi: 10.2174/1566524023666221213111851. [PMID: 36515031]
  • Zhaleh Jamali, Ahmad Salimi, Behzad Garmabi, Saleh Khezri, Mehdi Khaksari. Hesperidin Protects Alcohol-induced Mitochondrial Abnormalities via the Inhibition of Oxidative Stress and MPT Pore opening in Newborn Male Rats as Fetal Alcohol Syndrome Model. Journal of studies on alcohol and drugs. 2023 Dec; ?(?):. doi: 10.15288/jsad.23-00243. [PMID: 38147083]
  • Sanja Ćavar Zeljkovıć, Saliha Seyma Sahinler, Cengiz Sarikurkcu, Bulent Kirkan, Riza Binzet, Petr Tarkowski. Exploring the Pharmacological Potential of Onosma riedliana: Phenolic Compounds and Their Biological Activities. Plant foods for human nutrition (Dordrecht, Netherlands). 2023 Dec; ?(?):. doi: 10.1007/s11130-023-01131-0. [PMID: 38103155]
  • Blanca Sáenz de Miera, Raquel Cañadas, María González-Miquel, Emilio J González. Recovery of Phenolic Compounds from Orange Peel Waste by Conventional and Assisted Extraction Techniques Using Sustainable Solvents. Frontiers in bioscience (Elite edition). 2023 12; 15(4):30. doi: 10.31083/j.fbe1504030. [PMID: 38163939]
  • Merve Akkulak, Emre Evin, Ozlem Durukan, Hasan Ufuk Celebioglu, Orhan Adali. Modulation of Caco-2 Colon Cancer Cell Viability and CYP2W1 Gene Expression by Hesperidin-treated Lacticaseibacillus rhamnosus GG (LGG) Cell-free Supernatants. Anti-cancer agents in medicinal chemistry. 2023 Dec; ?(?):. doi: 10.2174/0118715206271514231124111026. [PMID: 38058098]
  • Jie Tang, Lixiang Wang, Mengge Shi, Shuaixia Feng, Tong Zhang, Han Han. Study on the mechanism of Shuganzhi Tablet against nonalcoholic fatty liver disease and lipid regulation effects of its main substances in vitro. Journal of ethnopharmacology. 2023 Nov; 316(?):116780. doi: 10.1016/j.jep.2023.116780. [PMID: 37311504]
  • Wenqian Wang, Lili Qu, Zhan Cui, Fuping Lu, Li Li, Fufeng Liu. Citrus Flavonoid Hesperetin Inhibits α-Synuclein Fibrillogenesis, Disrupts Mature Fibrils, and Reduces Their Cytotoxicity: In Vitro and In Vivo Studies. Journal of agricultural and food chemistry. 2023 Nov; 71(43):16174-16183. doi: 10.1021/acs.jafc.3c06816. [PMID: 37870747]
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