Verbascoside (BioDeep_00000184930)

   

human metabolite blood metabolite natural product


代谢物信息卡片


6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(3,4-dihydroxyphenyl)prop-2-enoic acid

化学式: C29H36O15 (624.2054106)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1OC(OC2C(O)C(OCCC3=CC=C(O)C(O)=C3)OC(CO)C2OC(=O)C=CC2=CC=C(O)C(O)=C2)C(O)C(O)C1O
InChI: InChI=1S/C29H36O15/c1-13-22(36)23(37)24(38)29(41-13)44-27-25(39)28(40-9-8-15-3-6-17(32)19(34)11-15)42-20(12-30)26(27)43-21(35)7-4-14-2-5-16(31)18(33)10-14/h2-7,10-11,13,20,22-34,36-39H,8-9,12H2,1H3

描述信息

同义名列表

5 个代谢物同义名

6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(3,4-dihydroxyphenyl)prop-2-enoic acid; 6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-3-yl 3-(3,4-dihydroxyphenyl)prop-2-enoate; Verbascoside; kusaginin; acteoside



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

901 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Anoop Kallingal, Varun Thachan Kundil, Aravind Ayyolath, Abraham Peele Karlapudi, Tomy Muringayil Joseph, Jayadevi Variyar E. Molecular modeling study of tectoquinone and acteoside from Tectona grandis linn: a new SARS-CoV-2 main protease inhibitor against COVID-19. Journal of biomolecular structure & dynamics. 2022 Mar; 40(4):1764-1775. doi: 10.1080/07391102.2020.1832580. [PMID: 33036548]
  • Mario Bernardi, Mohammad Reza Ghaani, Omer Bayazeid. Phenylethanoid glycosides as a possible COVID-19 protease inhibitor: a virtual screening approach. Journal of molecular modeling. 2021 Nov; 27(11):341. doi: 10.1007/s00894-021-04963-2. [PMID: 34731296]
  • Qinwen Wang, Xinxin Dai, Xiang Xiang, Zhuo Xu, Shulan Su, Dandan Wei, Tianyao Zheng, Er-Xin Shang, Dawei Qian, Jin-Ao Duan. A natural product of acteoside ameliorate kidney injury in diabetes db/db mice and HK-2 cells via regulating NADPH/oxidase-TGF-β/Smad signaling pathway. Phytotherapy research : PTR. 2021 Sep; 35(9):5227-5240. doi: 10.1002/ptr.7196. [PMID: 34236110]
  • Y Fan, K Zhang. Verbascoside inhibits the progression of atherosclerosis in high fat diet induced atherosclerosis rat model. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2021 Jun; 72(3):. doi: 10.26402/jpp.2021.3.03. [PMID: 34810286]
  • Yi Chen, Ying-Qi Li, Jia-Yi Fang, Ping Li, Fei Li. Establishment of the concurrent experimental model of osteoporosis combined with Alzheimer's disease in rat and the dual-effects of echinacoside and acteoside from Cistanche tubulosa. Journal of ethnopharmacology. 2020 Jul; 257(?):112834. doi: 10.1016/j.jep.2020.112834. [PMID: 32278031]
  • Meng-Qi Zhang, Xia Ren, Qing Zhao, Shi-Jun Yue, Xiu-Mei Fu, Xin Li, Kai-Xian Chen, Yue-Wei Guo, Chang-Lun Shao, Chang-Yun Wang. Hepatoprotective effects of total phenylethanoid glycosides from Acanthus ilicifolius L. against carbon tetrachloride-induced hepatotoxicity. Journal of ethnopharmacology. 2020 Jun; 256(?):112795. doi: 10.1016/j.jep.2020.112795. [PMID: 32224197]
  • Hongbing Ma, Shourong Qin, Shaoheng Zhao. Osteoarthritis is Prevented in Rats by Verbascoside via Nuclear Factor kappa B (NF-κB) Pathway Downregulation. Medical science monitor : international medical journal of experimental and clinical research. 2020 Apr; 26(?):e921276. doi: 10.12659/msm.921276. [PMID: 32249762]
  • Maoxing Li, Yuting Zhu, Jing Li, Liping Chen, Wendi Tao, Xiaoling Li, Yan Qiu. Effect and mechanism of verbascoside on hypoxic memory injury in plateau. Phytotherapy research : PTR. 2019 Oct; 33(10):2692-2701. doi: 10.1002/ptr.6443. [PMID: 31364205]
  • Yi Zhang, Mengyang Liu, Qian Chen, Tingting Wang, Haiyang Yu, Jingqi Xu, Tao Wang. Leaves of Lippia triphylla improve hepatic lipid metabolism via activating AMPK to regulate lipid synthesis and degradation. Journal of natural medicines. 2019 Sep; 73(4):707-716. doi: 10.1007/s11418-019-01316-5. [PMID: 31104252]
  • Mengqi Zhang, Xia Ren, Shijun Yue, Qing Zhao, Changlun Shao, Changyun Wang. Simultaneous Quantification of Four Phenylethanoid Glycosides in Rat Plasma by UPLC-MS/MS and Its Application to a Pharmacokinetic Study of Acanthus Ilicifolius Herb. Molecules (Basel, Switzerland). 2019 Aug; 24(17):. doi: 10.3390/molecules24173117. [PMID: 31466218]
  • S Lupinacci, Anna Perri, G Toteda, D Vizza, F Puoci, O I Parisi, F Giordano, D Lofaro, A La Russa, M Bonofiglio, R Bonofiglio. Olive leaf extract counteracts epithelial to mesenchymal transition process induced by peritoneal dialysis, through the inhibition of TGFβ1 signaling. Cell biology and toxicology. 2019 04; 35(2):95-109. doi: 10.1007/s10565-018-9438-9. [PMID: 29978330]
  • Bingwei Feng, Yonggui Song, Qiongming Xu, Pengfei Xu, Qiang Zeng, Baixi Shan, Kuangyi Liu, Dan Su. Simultaneous determination of savaside A, acteoside, and isoacteoside in rat plasma by UHPLC-MS/MS: Comparative pharmacokinetic and bioavailability characteristics of Monochasma savatieri via different routes of administration. Journal of separation science. 2018 Dec; 41(24):4408-4418. doi: 10.1002/jssc.201800545. [PMID: 30307101]
  • Jin-Hua Tao, Min Zhao, Shu Jiang, Wei Zhang, Bo-Hui Xu, Jin-Ao Duan. UPLC-Q-TOF/MS-based metabolic profiling comparison of four major bioactive components in normal and CKD rat plasma, urine and feces following oral administration of Cornus officinalis Sieb and Rehmannia glutinosa Libosch herb couple extract. Journal of pharmaceutical and biomedical analysis. 2018 Nov; 161(?):254-261. doi: 10.1016/j.jpba.2018.08.051. [PMID: 30172880]
  • Lu Gan, Xiaozhao Li, Mengyuan Zhu, Chen Chen, Huimin Luo, Qiaoling Zhou. Acteoside relieves mesangial cell injury by regulating Th22 cell chemotaxis and proliferation in IgA nephropathy. Renal failure. 2018 Nov; 40(1):364-370. doi: 10.1080/0886022x.2018.1450762. [PMID: 29708439]
  • Christina Cheimonidi, Pinelopi Samara, Panagiotis Polychronopoulos, Eleni N Tsakiri, Theodora Nikou, Vassilios Myrianthopoulos, Theodore Sakellaropoulos, Vassilis Zoumpourlis, Emmanuel Mikros, Issidora Papassideri, Aikaterini Argyropoulou, Maria Halabalaki, Leonidas G Alexopoulos, Alexios-Leandros Skaltsounis, Ourania E Tsitsilonis, Nektarios N Aligiannis, Ioannis P Trougakos. Selective cytotoxicity of the herbal substance acteoside against tumor cells and its mechanistic insights. Redox biology. 2018 06; 16(?):169-178. doi: 10.1016/j.redox.2018.02.015. [PMID: 29505920]
  • Qingling Cui, Yingni Pan, Wei Zhang, Yanan Zhang, Shumeng Ren, Dongmei Wang, Zhenzhong Wang, Xiaoqiu Liu, Wei Xiao. Metabolites of Dietary Acteoside: Profiles, Isolation, Identification, and Hepatoprotective Capacities. Journal of agricultural and food chemistry. 2018 Mar; 66(11):2660-2668. doi: 10.1021/acs.jafc.7b04650. [PMID: 29478321]
  • Xin-Xin Dai, Shu-Lan Su, Hong-Die Cai, Dan-Dan Wei, Tian-Yao Zheng, Zhen-Hua Zhu, Hui Yan, Er-Xin Shang, Sheng Guo, Da-Wei Qian, Jin-Ao Duan. Comparative pharmacokinetics of acteoside from total glycoside extracted from leaves of Rehmannia and Dihuangye total glycoside capsule in normal and diabetic nephropathy rats. Biomedical chromatography : BMC. 2017 Dec; 31(12):. doi: 10.1002/bmc.4013. [PMID: 28543613]
  • Syed Haris Omar, Philip G Kerr, Christopher J Scott, Adam S Hamlin, Hassan K Obied. Olive (Olea europaea L.) Biophenols: A Nutriceutical against Oxidative Stress in SH-SY5Y Cells. Molecules (Basel, Switzerland). 2017 Oct; 22(11):. doi: 10.3390/molecules22111858. [PMID: 29109370]
  • A G D'Alessandro, F Vizzarri, M Palazzo, G Martemucci. Dietary verbascoside supplementation in donkeys: effects on milk fatty acid profile during lactation, and serum biochemical parameters and oxidative markers. Animal : an international journal of animal bioscience. 2017 Sep; 11(9):1505-1512. doi: 10.1017/s1751731117000441. [PMID: 28264745]
  • Ling Zhang, Qiao-Yan Cai, Zhi-Xiong Cai, Yi Fang, Chun-Song Zheng, Li-Li Wang, Shan Lin, Da-Xin Chen, Jun Peng. Interactions of Bovine Serum Albumin with Anti-Cancer Compounds Using a ProteOn XPR36 Array Biosensor and Molecular Docking. Molecules (Basel, Switzerland). 2016 Dec; 21(12):. doi: 10.3390/molecules21121706. [PMID: 27973422]
  • Qingling Cui, Yingni Pan, Xuewei Bai, Wei Zhang, Lixia Chen, Xiaoqiu Liu. Systematic characterization of the metabolites of echinacoside and acteoside from Cistanche tubulosa in rat plasma, bile, urine and feces based on UPLC-ESI-Q-TOF-MS. Biomedical chromatography : BMC. 2016 Sep; 30(9):1406-15. doi: 10.1002/bmc.3698. [PMID: 26856531]
  • Dan Su, Wei Li, Qiongming Xu, Yali Liu, Yonggui Song, Yulin Feng. New metabolites of acteoside identified by ultra-performance liquid chromatography/quadrupole-time-of-flight MS(E) in rat plasma, urine, and feces. Fitoterapia. 2016 Jul; 112(?):45-55. doi: 10.1016/j.fitote.2016.05.004. [PMID: 27223850]
  • Y Wen, S Huo, W Zhang, H Xing, L Qi, D Zhao, N Li, J Xu, M Yan, X Chen. Pharmacokinetics, Biodistribution, Excretion and Plasma Protein Binding Studies of Acteoside in Rats. Drug research. 2016 Mar; 66(3):148-53. doi: 10.1055/s-0035-1555896. [PMID: 26241371]
  • Min Zhao, Jinhua Tao, Dawei Qian, Pei Liu, Er-xin Shang, Shu Jiang, Jianming Guo, Shu-lan Su, Jin-ao Duan, Leyue Du. Simultaneous determination of loganin, morroniside, catalpol and acteoside in normal and chronic kidney disease rat plasma by UPLC-MS for investigating the pharmacokinetics of Rehmannia glutinosa and Cornus officinalis Sieb drug pair extract. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jan; 1009-1010(?):122-9. doi: 10.1016/j.jchromb.2015.12.020. [PMID: 26720701]
  • Ji Hye Lee, Ju Lan Chun, Keun Jung Kim, Eun Young Kim, Dong-Hee Kim, Bo Myeong Lee, Kil Woo Han, Kang-Sun Park, Kyung-Bon Lee, Min Kyu Kim. Effect of Acteoside as a Cell Protector to Produce a Cloned Dog. PloS one. 2016; 11(7):e0159330. doi: 10.1371/journal.pone.0159330. [PMID: 27428333]
  • Min Zhao, Dawei Qian, Pei Liu, Er-xin Shang, Shu Jiang, Jianming Guo, Shu-lan Su, Jin-ao Duan, Leyue Du, Jinhua Tao. Comparative pharmacokinetics of catalpol and acteoside in normal and chronic kidney disease rats after oral administration of Rehmannia glutinosa extract. Biomedical chromatography : BMC. 2015 Dec; 29(12):1842-8. doi: 10.1002/bmc.3505. [PMID: 26031219]
  • A Di Giancamillo, R Rossi, G Pastorelli, D Deponti, V Carollo, D Casamassima, C Domeneghini, C Corino. The effects of dietary verbascoside on blood and liver oxidative stress status induced by a high n-6 polyunsaturated fatty acids diet in piglets. Journal of animal science. 2015 Jun; 93(6):2849-59. doi: 10.2527/jas.2014-8607. [PMID: 26115272]
  • Izabela Grzegorczyk-Karolak, Halina Wysokińska, Beata Olas. Studies on the antioxidant properties of extracts from the roots and shoots of two Scutellaria species in human blood plasma. Acta biochimica Polonica. 2015; 62(2):253-8. doi: 10.18388/abp.2014_944. [PMID: 26015995]
  • Jun Zhou, Qiong Zhang, Jiang Bing Sun, Xiao Li Sun, Ping Zeng. Two-phase hollow fiber liquid phase microextraction based on magnetofluid for simultaneous determination of Echinacoside, Tubuloside B, Acteoside and Isoacteoside in rat plasma after oral administration of Cistanche salsa extract by high performance liquid chromatography. Journal of pharmaceutical and biomedical analysis. 2014 Jun; 94(?):30-5. doi: 10.1016/j.jpba.2014.01.013. [PMID: 24531006]
  • Yujuan Li, Lin Gan, George Q Li, Li Deng, Xinshi Zhang, Yulin Deng. Pharmacokinetics of plantamajoside and acteoside from Plantago asiatica in rats by liquid chromatography-mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2014 Feb; 89(?):251-6. doi: 10.1016/j.jpba.2013.11.014. [PMID: 24316425]
  • Angela G D'Alessandro, Donato Casamassima, Felicita Jirillo, Giovanni Martemucci. Effects of verbascoside administration on the blood parameters and oxidative status in jennies and their suckling foals: potential improvement of milk for human use. Endocrine, metabolic & immune disorders drug targets. 2014; 14(2):102-12. doi: 10.2174/1871530314666140407152347. [PMID: 24712667]
  • Meng Qi, Aizhen Xiong, Pengfei Li, Qiming Yang, Li Yang, Zhengtao Wang. Identification of acteoside and its major metabolites in rat urine by ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Dec; 940(?):77-85. doi: 10.1016/j.jchromb.2013.09.023. [PMID: 24141042]
  • R Quirantes-Piné, M Herranz-López, L Funes, I Borrás-Linares, V Micol, A Segura-Carretero, A Fernández-Gutiérrez. Phenylpropanoids and their metabolites are the major compounds responsible for blood-cell protection against oxidative stress after administration of Lippia citriodora in rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Sep; 20(12):1112-8. doi: 10.1016/j.phymed.2013.05.007. [PMID: 23827667]
  • Xiuman Sun, Qiongfeng Liao, Guanghui Liu, Hao Cai, Lei Zhang, Chenchen Zhu, Zhiyong Xie. Simultaneous determination of three phenylethanoid glycosides from Callicarpae Caulis et Folium in rat plasma by LC-MS/MS and its application to PK study. Bioanalysis. 2013 Aug; 5(15):1883-95. doi: 10.4155/bio.13.124. [PMID: 23905862]
  • Eun Sun Seo, Bo Kang Oh, Jhang Ho Pak, Soon-Ho Yim, Sangilyandi Gurunathan, Young-Pil Kim, Kyung Jin Lee. Acteoside improves survival in cecal ligation and puncture-induced septic mice via blocking of high mobility group box 1 release. Molecules and cells. 2013 Apr; 35(4):348-54. doi: 10.1007/s10059-013-0021-1. [PMID: 23563799]
  • HongYu Qiu, WenXing Fan, Ping Fu, Chuan Zuo, Ping Feng, Fang Liu, Li Zhou, Feng Chen, Hui Zhong, YaPing Liang, Mei Shi. General acteoside of Rehmanniae leaves in the treatment of primary chronic glomerulonephritis: a randomized controlled trial. African journal of traditional, complementary, and alternative medicines : AJTCAM. 2013; 10(4):109-15. doi: 10.4314/ajtcam.v10i4.18. [PMID: 24146510]
  • Jun Xie, Feng Tan, Jing Zhu, Caibo Yue, Qi Li. Separation, purification and quantification of verbascoside from Penstemon barbatus (Cav.) Roth. Food chemistry. 2012 Dec; 135(4):2536-41. doi: 10.1016/j.foodchem.2012.07.021. [PMID: 22980839]
  • Cristiano Soleo Funari, Fernanda Patrícia Gullo, Assunta Napolitano, Renato Lajarim Carneiro, Maria José Soares Mendes-Giannini, Ana Marisa Fusco-Almeida, Sonia Piacente, Cosimo Pizza, Dulce Helena Siqueira Silva. Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil. Food chemistry. 2012 Dec; 135(3):2086-94. doi: 10.1016/j.foodchem.2012.06.077. [PMID: 22953960]
  • A Venditti, A M Serrilli, M Di Cecco, G Ciaschetti, T Andrisano, A Bianco. Phytochemical analysis of Plantago sempervirens from Majella National Park. Natural product research. 2012 Nov; 26(21):2035-9. doi: 10.1080/14786419.2011.633520. [PMID: 22081901]
  • Pei-Pei Wu, Shi-Xia Huo, Li Gao, Jian-Mei Li, Juan Lin, Liang-Mo Cai, Ming Yan, Yi Huang, Abudukeremu Kaisaier. [Pharmacokinetic study on acetoside in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Nov; 37(21):3312-5. doi: 10.4268/cjcmm20122132. [PMID: 23397736]
  • Augusto G Filho, Ademir F Morel, Luciana Adolpho, Vinícius Ilha, Ernest Giralt, Teresa Tarragó, Ionara I Dalcol. Inhibitory effect of verbascoside isolated from Buddleja brasiliensis Jacq. ex Spreng on prolyl oligopeptidase activity. Phytotherapy research : PTR. 2012 Oct; 26(10):1472-5. doi: 10.1002/ptr.4597. [PMID: 22275311]
  • Gianluca Campo, Jlenia Marchesini, Laura Bristot, Monia Monti, Stefania Gambetti, Rita Pavasini, Alberto Pollina, Roberto Ferrari. The in vitro effects of verbascoside on human platelet aggregation. Journal of thrombosis and thrombolysis. 2012 Oct; 34(3):318-25. doi: 10.1007/s11239-012-0757-z. [PMID: 22723176]
  • Fiammetta Alagna, Roberto Mariotti, Francesco Panara, Silvia Caporali, Stefania Urbani, Gianluca Veneziani, Sonia Esposto, Agnese Taticchi, Adolfo Rosati, Rosa Rao, Gaetano Perrotta, Maurizio Servili, Luciana Baldoni. Olive phenolic compounds: metabolic and transcriptional profiling during fruit development. BMC plant biology. 2012 Sep; 12(?):162. doi: 10.1186/1471-2229-12-162. [PMID: 22963618]
  • Anna Sgarbossa, Martina Dal Bosco, Giovanna Pressi, Salvatore Cuzzocrea, Roberto Dal Toso, Marta Menegazzi. Phenylpropanoid glycosides from plant cell cultures induce heme oxygenase 1 gene expression in a human keratinocyte cell line by affecting the balance of NRF2 and BACH1 transcription factors. Chemico-biological interactions. 2012 Aug; 199(2):87-95. doi: 10.1016/j.cbi.2012.06.006. [PMID: 22735309]
  • L Carrera-Quintanar, L Funes, E Viudes, J Tur, V Micol, E Roche, A Pons. Antioxidant effect of lemon verbena extracts in lymphocytes of university students performing aerobic training program. Scandinavian journal of medicine & science in sports. 2012 Aug; 22(4):454-61. doi: 10.1111/j.1600-0838.2010.01244.x. [PMID: 21083769]
  • Chiara Righeschi, Tolga Eichhorn, Anastasia Karioti, Anna Rita Bilia, Thomas Efferth. Microarray-based mRNA expression profiling of leukemia cells treated with the flavonoid, casticin. Cancer genomics & proteomics. 2012 May; 9(3):143-51. doi: . [PMID: 22593249]
  • U Sebnem Harput, Yasin Genc, Iclal Saracoglu. Cytotoxic and antioxidative activities of Plantago lagopus L. and characterization of its bioactive compounds. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 May; 50(5):1554-9. doi: 10.1016/j.fct.2012.01.019. [PMID: 22289578]
  • Zhen Liu, Zhiwei Xu, Hanyu Zhou, Gang Cao, Xiao-Dong Cong, Yun Zhang, Bao-Chang Cai. Simultaneous determination of four bioactive compounds in Verbena officinalis L. by using high-performance liquid chromatography. Pharmacognosy magazine. 2012 Apr; 8(30):162-5. doi: 10.4103/0973-1296.96575. [PMID: 22701291]
  • Niaz Ali, Syed Wadood Ali Shah, Ismail Shah, Ghayour Ahmed, Mehreen Ghias, Imran Khan, Waqar Ali. Anthelmintic and relaxant activities of Verbascum Thapsus Mullein. BMC complementary and alternative medicine. 2012 Mar; 12(?):29. doi: 10.1186/1472-6882-12-29. [PMID: 22463730]
  • Andrea Bellincontro, Agnese Taticchi, Maurizio Servili, Sonia Esposto, Daniela Farinelli, Fabio Mencarelli. Feasible application of a portable NIR-AOTF tool for on-field prediction of phenolic compounds during the ripening of olives for oil production. Journal of agricultural and food chemistry. 2012 Mar; 60(10):2665-73. doi: 10.1021/jf203925a. [PMID: 22339361]
  • Amel Boudjelal, Cherifa Henchiri, Laura Siracusa, Madani Sari, Giuseppe Ruberto. Compositional analysis and in vivo anti-diabetic activity of wild Algerian Marrubium vulgare L. infusion. Fitoterapia. 2012 Mar; 83(2):286-92. doi: 10.1016/j.fitote.2011.11.005. [PMID: 22100836]
  • Angela Cardinali, Sandra Pati, Fiorenza Minervini, Isabella D'Antuono, Vito Linsalata, Vincenzo Lattanzio. Verbascoside, isoverbascoside, and their derivatives recovered from olive mill wastewater as possible food antioxidants. Journal of agricultural and food chemistry. 2012 Feb; 60(7):1822-9. doi: 10.1021/jf204001p. [PMID: 22268549]
  • Chiara Francesca Guarnerio, Marica Fraccaroli, Irene Gonzo, Giovanna Pressi, Roberto Dal Toso, Flavia Guzzo, Marisa Levi. Metabolomic analysis reveals that the accumulation of specific secondary metabolites in Echinacea angustifolia cells cultured in vitro can be controlled by light. Plant cell reports. 2012 Feb; 31(2):361-7. doi: 10.1007/s00299-011-1171-2. [PMID: 22009052]
  • Sebastian E W Opitz, Jean-Luc Boevé, Zoltán Tamás Nagy, Gontran Sonet, Frank Koch, Caroline Müller. Host shifts from Lamiales to Brassicaceae in the sawfly genus Athalia. PloS one. 2012; 7(4):e33649. doi: 10.1371/journal.pone.0033649. [PMID: 22485146]
  • Rahele Ghanbari, Farooq Anwar, Khalid M Alkharfy, Anwarul-Hassan Gilani, Nazamid Saari. Valuable nutrients and functional bioactives in different parts of olive (Olea europaea L.)-a review. International journal of molecular sciences. 2012; 13(3):3291-3340. doi: 10.3390/ijms13033291. [PMID: 22489153]
  • Ana Lúcia A Arruda, Carla J B Vieira, Daniella G Sousa, Regilene F Oliveira, Rachel O Castilho. Jacaranda cuspidifolia Mart. (Bignoniaceae) as an antibacterial agent. Journal of medicinal food. 2011 Dec; 14(12):1604-8. doi: 10.1089/jmf.2010.0251. [PMID: 21663482]
  • Cristiano Soleo Funari, Thais Gaban Passalacqua, Daniel Rinaldo, Assunta Napolitano, Michela Festa, Anna Capasso, Sonia Piacente, Cosimo Pizza, Maria Claudia Marx Young, Giselda Durigan, Dulce Helena Siqueira Silva. Interconverting flavanone glucosides and other phenolic compounds in Lippia salviaefolia Cham. ethanol extracts. Phytochemistry. 2011 Nov; 72(16):2052-61. doi: 10.1016/j.phytochem.2011.07.004. [PMID: 21871644]
  • Nuria Caturla, Lorena Funes, Laura Pérez-Fons, Vicente Micol. A randomized, double-blinded, placebo-controlled study of the effect of a combination of lemon verbena extract and fish oil omega-3 fatty acid on joint management. Journal of alternative and complementary medicine (New York, N.Y.). 2011 Nov; 17(11):1051-63. doi: 10.1089/acm.2010.0410. [PMID: 22087615]
  • Thomas A K Prescott, Nigel C Veitch, Monique S J Simmonds. Direct inhibition of calcineurin by caffeoyl phenylethanoid glycosides from Teucrium chamaedrys and Nepeta cataria. Journal of ethnopharmacology. 2011 Oct; 137(3):1306-10. doi: 10.1016/j.jep.2011.07.063. [PMID: 21843624]
  • Alla I Potapovich, Daniela Lulli, Paolo Fidanza, Vladimir A Kostyuk, Chiara De Luca, Saveria Pastore, Liudmila G Korkina. Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFκB and AhR and EGFR-ERK pathway. Toxicology and applied pharmacology. 2011 Sep; 255(2):138-49. doi: 10.1016/j.taap.2011.06.007. [PMID: 21756928]
  • Zong-Hua Song, Yan-Hong Wang, Zhong-Zhi Qian, Troy J Smillie, Ikhlas A Khan. Quantitative determination of 10 phenylpropanoid and lignan compounds in Lancea tibetica by high-performance liquid chromatography with UV detection. Planta medica. 2011 Sep; 77(13):1562-6. doi: 10.1055/s-0030-1270833. [PMID: 21347996]
  • Antonia Mestre-Alfaro, Miguel D Ferrer, Antoni Sureda, Pedro Tauler, Elisa Martínez, Maria M Bibiloni, Vicente Micol, Josep A Tur, Antoni Pons. Phytoestrogens enhance antioxidant enzymes after swimming exercise and modulate sex hormone plasma levels in female swimmers. European journal of applied physiology. 2011 Sep; 111(9):2281-94. doi: 10.1007/s00421-011-1862-y. [PMID: 21331628]
  • Rabea Sutter, Caroline Müller. Mining for treatment-specific and general changes in target compounds and metabolic fingerprints in response to herbivory and phytohormones in Plantago lanceolata. The New phytologist. 2011 Sep; 191(4):1069-1082. doi: 10.1111/j.1469-8137.2011.03768.x. [PMID: 21592133]
  • Silvia Vertuani, Erika Beghelli, Emanuela Scalambra, Gemma Malisardi, Stefano Copetti, Roberto Dal Toso, Anna Baldisserotto, Stefano Manfredini. Activity and stability studies of verbascoside, a novel antioxidant, in dermo-cosmetic and pharmaceutical topical formulations. Molecules (Basel, Switzerland). 2011 Aug; 16(8):7068-80. doi: 10.3390/molecules16087068. [PMID: 21852765]
  • Zeliha Akdemir, Ciğdem Kahraman, I Irem Tatlı, Esra Küpeli Akkol, Ipek Süntar, Hikmet Keles. Bioassay-guided isolation of anti-inflammatory, antinociceptive and wound healer glycosides from the flowers of Verbascum mucronatum Lam. Journal of ethnopharmacology. 2011 Jul; 136(3):436-43. doi: 10.1016/j.jep.2010.05.059. [PMID: 20621642]
  • Carolina Arevalo, Ines Ruiz, Anna Lisa Piccinelli, Luca Campone, Luca Rastrelli. Phenolic derivatives from the leaves of Martinella obovata (Bignoniaceae). Natural product communications. 2011 Jul; 6(7):957-60. doi: ". [PMID: 21834232]
  • J Flemmig, K Kuchta, J Arnhold, H W Rauwald. Olea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2011 May; 18(7):561-6. doi: 10.1016/j.phymed.2010.10.021. [PMID: 21144719]
  • Vladimir A Kostyuk, Alla I Potapovich, Tatyana O Suhan, Chiara de Luca, Liudmila G Korkina. Antioxidant and signal modulation properties of plant polyphenols in controlling vascular inflammation. European journal of pharmacology. 2011 May; 658(2-3):248-56. doi: 10.1016/j.ejphar.2011.02.022. [PMID: 21371465]
  • Rosanna D I Paola, Giacomo Oteri, Emanuela Mazzon, Concetta Crisafulli, Maria Galuppo, Roberto D A L Toso, Giovanna Pressi, Giancarlo Cordasco, Salvatore Cuzzocrea. Effects of verbascoside, biotechnologically purified by Syringa vulgaris plant cell cultures, in a rodent model of periodontitis. The Journal of pharmacy and pharmacology. 2011 May; 63(5):707-17. doi: 10.1111/j.2042-7158.2011.01262.x. [PMID: 21492173]
  • Milen I Georgiev, Jutta Ludwig-Müller, Kalina Alipieva, Annemarie Lippert. Sonication-assisted Agrobacterium rhizogenes-mediated transformation of Verbascum xanthophoeniceum Griseb. for bioactive metabolite accumulation. Plant cell reports. 2011 May; 30(5):859-66. doi: 10.1007/s00299-010-0981-y. [PMID: 21184229]
  • Xiaofei Wang, Chen Li, Yewei Liu, Hongbing Li, Duolong Di. Efficient method for screening and identification of radical scavengers in the leaves of Olea europaea L. Biomedical chromatography : BMC. 2011 Mar; 25(3):373-80. doi: 10.1002/bmc.1458. [PMID: 21321972]
  • Milen Georgiev, Jutta Ludwig-Müller, Jost Weber, Nina Stancheva, Thomas Bley. Bioactive metabolite production and stress-related hormones in Devil's claw cell suspension cultures grown in bioreactors. Applied microbiology and biotechnology. 2011 Mar; 89(6):1683-91. doi: 10.1007/s00253-010-3008-2. [PMID: 21104241]
  • Mariana Domínguez, Jose G Avila, Antonio Nieto, Carlos L Céspedes. Anti-inflammatory activity of Penstemon gentianoides and Penstemon campanulatus. Pharmaceutical biology. 2011 Feb; 49(2):118-24. doi: 10.3109/13880209.2010.503708. [PMID: 20979542]
  • N M Abdel-Hamid, M A El-Moselhy, A El-Baz. Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats. International journal of hepatology. 2011; 2011(?):736581. doi: 10.4061/2011/736581. [PMID: 21994869]
  • Abbas Delazar, Mohammad R Delnavazi, Lutfun Nahar, Sadeigh B Moghadam, Mahdi Mojarab, Abhishek Gupta, Angela S Williams, M Mukhlesur Rahman, Satyajit D Sarker. Lavandulifolioside B: a new phenylethanoid glycoside from the aerial parts of Stachys lavandulifolia Vahl. Natural product research. 2011 Jan; 25(1):8-16. doi: 10.1080/14786411003754330. [PMID: 21240755]
  • Jasmina Petreska, Gjose Stefkov, Svetlana Kulevanova, Kalina Alipieva, Vassya Bankova, Marina Stefova. Phenolic compounds of mountain tea from the Balkans: LC/DAD/ESI/MSn profile and content. Natural product communications. 2011 Jan; 6(1):21-30. doi: . [PMID: 21366039]
  • Haytham M Wahba, Sameh F AbouZid, Amany A Sleem, Sandra Apers, Luc Pieters, Abdelaaty A Shahat. Chemical and biological investigation of some Clerodendrum species cultivated in Egypt. Pharmaceutical biology. 2011 Jan; 49(1):66-72. doi: 10.3109/13880209.2010.494674. [PMID: 20738216]
  • Eibhlín McCarthy, Jim M O'Mahony. What's in a Name? Can Mullein Weed Beat TB Where Modern Drugs Are Failing?. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):. doi: 10.1155/2011/239237. [PMID: 20953419]
  • Pawadee Noiarsa, Somsak Ruchirawat, Tripetch Kanchanapoom. Acanmontanoside, a new phenylethanoid diglycoside from Acanthus montanus. Molecules (Basel, Switzerland). 2010 Dec; 15(12):8967-72. doi: 10.3390/molecules15128967. [PMID: 21139534]
  • Manyuan Wang, Yuanjie Fan, Jing Zhang, Muxin Gong. [Simultaneous determination of plantainoside D and verbascoside from stem of Chirita longgangensis var. hongyao by RP-HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Dec; 35(23):3188-91. doi: 10.4268/cjcmm20102322. [PMID: 21355246]
  • Diana Cruz, Pedro L Falé, Ana Mourato, Pedro D Vaz, M Luisa Serralheiro, Ana Rosa L Lino. Preparation and physicochemical characterization of Ag nanoparticles biosynthesized by Lippia citriodora (Lemon Verbena). Colloids and surfaces. B, Biointerfaces. 2010 Nov; 81(1):67-73. doi: 10.1016/j.colsurfb.2010.06.025. [PMID: 20655710]
  • Neetu Singh, Nivedita Shukla, Pratibha Singh, Rolee Sharma, S M Rajendran, Rakesh Maurya, Gautam Palit. Verbascoside isolated from Tectona grandis mediates gastric protection in rats via inhibiting proton pump activity. Fitoterapia. 2010 Oct; 81(7):755-61. doi: 10.1016/j.fitote.2010.03.019. [PMID: 20388534]
  • Tiziana Genovese, Irene Paterniti, Emanuela Mazzon, Emanuela Esposito, Rosanna Di Paola, Maria Galuppo, Placido Bramanti, Salvatore Cuzzocrea. Efficacy of treatment with verbascoside, biotechnologically produced by Syringa vulgaris plant cell cultures in an experimental mice model of spinal cord trauma. Naunyn-Schmiedeberg's archives of pharmacology. 2010 Oct; 382(4):331-45. doi: 10.1007/s00210-010-0537-2. [PMID: 20799028]
  • Muhammad Shaiq Ali, Zeeshan Ahmed, Muhammad Imran Ali, Joseph Ngoupayo. Two new aromatic acids from Clerodendrum formicarum Gurke (Lamiaceae) of Cameroon. Journal of Asian natural products research. 2010 Oct; 12(10):894-8. doi: 10.1080/10286020.2010.509718. [PMID: 20924903]
  • Miroslav M Savić, Jelena M Kukić, Renée J Grayer, Marija M Milinković, Petar D Marin, Jovana Divljaković, Michael Van Linn, James M Cook, Silvana D Petrović. Behavioural characterization of four endemic Stachys taxa. Phytotherapy research : PTR. 2010 Sep; 24(9):1309-16. doi: 10.1002/ptr.3106. [PMID: 20127664]
  • Lorenza Speranza, Sara Franceschelli, Mirko Pesce, Marcella Reale, Luigi Menghini, Isabella Vinciguerra, Maria Anna De Lutiis, Mario Felaco, Alfredo Grilli. Antiinflammatory effects in THP-1 cells treated with verbascoside. Phytotherapy research : PTR. 2010 Sep; 24(9):1398-404. doi: 10.1002/ptr.3173. [PMID: 20812283]
  • M Zhu, N Tan, H Zhu, G Zeng, W He, B Yu, X Chen. Anti-sports anaemia effects of verbascoside and martynoside in mice. International journal of sports medicine. 2010 Aug; 31(8):537-41. doi: 10.1055/s-0030-1254115. [PMID: 20556696]
  • Vediha Homova, Jost Weber, Josef Schulze, Kalina Alipieva, Thomas Bley, Milen Georgiev. Devil's claw hairy root culture in flasks and in a 3-L bioreactor: bioactive metabolite accumulation and flow cytometry. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2010 Jul; 65(7-8):472-8. doi: 10.1515/znc-2010-7-809. [PMID: 20737916]
  • Víctor López, Anna K Jäger, Silvia Akerreta, Rita Yolanda Cavero, Maria Isabel Calvo. Antioxidant activity and phenylpropanoids of Phlomis lychnitis L.: a traditional herbal tea. Plant foods for human nutrition (Dordrecht, Netherlands). 2010 Jun; 65(2):179-85. doi: 10.1007/s11130-010-0169-1. [PMID: 20422294]
  • Miao Ye, Yun Zhao, Vanessa L Norman, Courtney M Starks, Stephanie M Rice, Matt G Goering, Mark O'Neil-Johnson, Gary R Eldridge, Jin-Feng Hu. Antibiofilm phenylethanoid glycosides from Penstemon centranthifolius. Phytotherapy research : PTR. 2010 May; 24(5):778-81. doi: 10.1002/ptr.2992. [PMID: 19827017]
  • Xiaojun Huang, Zhiqi Yin, Wencai Ye, Wenbin Shen. [Chemical constituents from fruits of Ligustrum lucidum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Apr; 35(7):861-4. doi: 10.4268/cjcmm20100712. [PMID: 20575386]
  • Nassima Abdelouahab Ouitas, Charles Heard. Estimation of the relative antiinflammatory efficacies of six commercial preparations of Harpagophytum procumbens (Devil's Claw). Phytotherapy research : PTR. 2010 Mar; 24(3):333-8. doi: 10.1002/ptr.2930. [PMID: 19610038]
  • Lorena Funes, Olga Laporta, Manuela Cerdán-Calero, Vicente Micol. Effects of verbascoside, a phenylpropanoid glycoside from lemon verbena, on phospholipid model membranes. Chemistry and physics of lipids. 2010 Feb; 163(2):190-9. doi: 10.1016/j.chemphyslip.2009.11.004. [PMID: 19925782]
  • Lisieux de Santana Julião, Suzana Guimarães Leitão, Cinzia Lotti, Anna Lisa Picinelli, Luca Rastrelli, Patricia D Fernandes, François Noël, Jean-Pierre Barros Thibaut, Gilda Guimarães Leitão. Flavones and phenylpropanoids from a sedative extract of Lantana trifolia L. Phytochemistry. 2010 Feb; 71(2-3):294-300. doi: 10.1016/j.phytochem.2009.10.007. [PMID: 19922967]
  • Emanuela Esposito, Roberto Dal Toso, Giovanna Pressi, Placido Bramanti, Rosaria Meli, Salvatore Cuzzocrea. Protective effect of verbascoside in activated C6 glioma cells: possible molecular mechanisms. Naunyn-Schmiedeberg's archives of pharmacology. 2010 Jan; 381(1):93-105. doi: 10.1007/s00210-009-0466-0. [PMID: 19904526]
  • Fernanda O Martins, Patricia F Esteves, Gabriella S Mendes, Nanci S Barbi, Fabio S Menezes, Maria T V Romanos. Verbascoside isolated from Lepechinia speciosa has inhibitory activity against HSV-1 and HSV-2 in vitro. Natural product communications. 2009 Dec; 4(12):1693-6. doi: ". [PMID: 20120109]
  • Chiharu Sadakane, Tomohisa Hattori, Junichi Koseki, Yayoi Inagaki, Yoshihiro Hasegawa, Shoichiro Shindo, Shuichi Takeda, Hiroshi Takeda. TJN-259 improves mesangial lesions in experimental immunoglobulin A nephropathy in ddY mice. Biological & pharmaceutical bulletin. 2009 Oct; 32(10):1728-33. doi: 10.1248/bpb.32.1728. [PMID: 19801835]
  • Carmen Romero-Segura, Carlos Sanz, Ana G Perez. Purification and characterization of an olive fruit beta-glucosidase involved in the biosynthesis of virgin olive oil phenolics. Journal of agricultural and food chemistry. 2009 Sep; 57(17):7983-8. doi: 10.1021/jf901293c. [PMID: 19689134]
  • Maryan Bruzual De Abreu, Nicola Malafronte, Phan Van Kiem, Alessandra Braca. A new iridoid from Adenosma caeruleum R. Br. Fitoterapia. 2009 Sep; 80(6):358-60. doi: 10.1016/j.fitote.2009.05.003. [PMID: 19442709]