Ellagic acid (BioDeep_00000001674)

 

Secondary id: BioDeep_00000398871

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs Antitumor activity natural product Volatile Flavor Compounds


代谢物信息卡片


6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(14),4(16),5,7,11(15),12-hexaene-3,10-dione

化学式: C14H6O8 (302.0062676)
中文名称: 鞣花酸
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.52%

Reviewed

Last reviewed on 2024-07-24.

Cite this Page

Ellagic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/ellagic_acid (retrieved 2024-11-23) (BioDeep RN: BioDeep_00000001674). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1=C2C3=C(C(=C1O)O)OC(=O)C4=CC(=C(C(=C43)OC2=O)O)O
InChI: InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H

描述信息

Ellagic acid appears as cream-colored needles (from pyridine) or yellow powder. Odorless. (NTP, 1992)
Ellagic acid is an organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates. It has a role as an antioxidant, a food additive, a plant metabolite, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an EC 1.14.18.1 (tyrosinase) inhibitor, an EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor, an EC 2.4.1.1 (glycogen phosphorylase) inhibitor, an EC 2.5.1.18 (glutathione transferase) inhibitor, an EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor, an EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor, an EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor, a skin lightening agent, a fungal metabolite, an EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor and a geroprotector. It is an organic heterotetracyclic compound, a cyclic ketone, a lactone, a member of catechols and a polyphenol. It is functionally related to a gallic acid.
Ellagic acid is present in several fruits such as cranberries, strawberries, raspberries, and pomegranates. In pomegranates, there are several therapeutic compounds but ellagic acid is the most active and abundant. Ellagic acid is also present in vegetables. Ellagic acid is an investigational drug studied for treatment of Follicular Lymphoma (phase 2 trial), protection from brain injury of intrauterine growth restricted babies (phase 1 and 2 trial), improvement of cardiovascular function in adolescents who are obese (phase 2 trial), and topical treatment of solar lentigines. Ellagic acids therapeutic action mostly involves antioxidant and anti-proliferative effects.
Ellagic acid is a natural product found in Fragaria chiloensis, Metrosideros perforata, and other organisms with data available.
Ellagic acid is a metabolite found in or produced by Saccharomyces cerevisiae.
A fused four ring compound occurring free or combined in galls. Isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used in research and as a dye.
Ellagic acid is an organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates. It has a role as an antioxidant, a food additive, a plant metabolite, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an EC 1.14.18.1 (tyrosinase) inhibitor, an EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor, an EC 2.4.1.1 (glycogen phosphorylase) inhibitor, an EC 2.5.1.18 (glutathione transferase) inhibitor, an EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor, an EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor, an EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor, a skin lightening agent, a fungal metabolite and an EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor. It is an organic heterotetracyclic compound, a cyclic ketone, a lactone, a member of catechols and a polyphenol. It derives from a gallic acid. Ellagic acid, also known as ellagate, belongs to the class of organic compounds known as hydrolyzable tannins. These are tannins with a structure characterized by either of the following models. In model 1, the structure contains galloyl units (in some cases, shikimic acid units) that are linked to diverse polyol carbohydrate-, catechin-, or triterpenoid units. In model 2, contains at least two galloyl units C-C coupled to each other, and do not contain a glycosidically linked catechin unit. The antiproliferative and antioxidant properties of ellagic acid have spurred preliminary research into the potential health benefits of ellagic acid consumption. Ellagic acids therapeutic action mostly involves antioxidant and anti-proliferative/anti-cancer effects. Ellagic acid is found, on average, in the highest concentration within a few different foods, such as chestnuts, common walnuts, and japanese walnuts and in a lower concentration in whiskies, arctic blackberries, and cloudberries. Ellagic acid has also been detected, but not quantified in several different foods, such as lowbush blueberries, bilberries, guava, strawberry guava, and bog bilberries.
An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates.
Widely distributed in higher plants especies dicotyledons. Intestinal astringent, dietary role disputed. Nutriceutical with anticancer and antioxidation props.
Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM.
Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM.

同义名列表

93 个代谢物同义名

6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(14),4(16),5,7,11(15),12-hexaene-3,10-dione; 6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(15),4(16),5,7,11,13-hexaene-3,10-dione; 6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(15),4,6,8(16),11,13-hexaene-3,10-dione; 6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(15),4,6,8(16),11,13-hexaene-3,10-dione; (1,1-Biphenyl)-2,2-dicarboxylic acid, 4,4,5,5,6,6-hexahydroxy-, di-.delta.-lactone; (1,1-Biphenyl)-2,2-dicarboxylic acid, 4,4,5,5,6,6-hexahydroxy-, di-delta-lactone; (1)Benzopyrano(5,4,3-cde)(1)benzopyran-5,10-dione, 2,3,7,8-tetrahydroxy-; [1]Benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione, 2,3,7,8-tetrahydroxy-; 2,3,7,8-Tetrahydroxy[1]benzopyrano-[5,4,3-cde][1]benzopyran-5,10-dione; [1]Benzopyrano[5,3-cde][1]benzopyran-5,10-dione, 2,3,7,8-tetrahydroxy-; 2,3,7,8-Tetrahydroxy(1)benzopyrano(5,4,3-cde)-(1)benzopyran-5,10-dione; 2,3,7,8-Tetrahydroxy(1)-benzopyrano(5,4,3-cde)(1)benzopyran-5,10-dione; 2,3,7,8-Tetrahydroxy(1)benzopyrano(5,4,3-cde)(1)-benzopyran-5,10-dione; 2,3,7,8-Tetrahydroxy-[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione; 2,3,7,8-Tetrahydroxy(1)benzopyrano(5,4,3-cde)(1)benzopyran-5,10-dione; 2,3,7,8-tetrahydroxy[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione; [1,2-dicarboxylic acid, 4,4,5,5,6,6-hexahydroxy-, di-.delta.-lactone; 2,3,7,8-Tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione #; 2,3,7,8-TETRAHYDROXY-CHROMENO[5,4,3-CDE]CHROMENE-5,10-DIONE; Diphenic acid, 4,4,5,5,6,6-hexahydroxy-, di-.delta.-lactone; 2,3,7,8-tetrahydroxychromeno(5,4,3-cde)chromene-5,10-dione; 2,3,7,8-Tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione; Diphenic acid, 4,4,5,5,6,6-hexahydroxy-, di-delta-lactone; Diphenic acid,4,5,5,6,6-hexahydroxy-, di-.delta.-lactone; Ellagic acid, primary pharmaceutical reference standard; 4,4,5,5,6,6-hexahydroxydiphenic acid 2,6,2,6-dilactone; 4,4,5,5,6,6-Hexahydrodiphenic acid 2,6,2,6-dilactone; 4,4,5,5,6,6-Hexahydroxydiphenate 2,6,2,6-dilactone; 5-19-07-00108 (Beilstein Handbook Reference); Ellagic acid, analytical standard; Ellagic acid, >=96.0\\% (HPCE); Acide ellagique [INN-French]; Acidum ellagicum [INN-Latin]; Acide ellagique (INN-French); Acido elagico [INN-Spanish]; Ellagic acid [INN:DCF]; Ellagic Acid Dihydrate; Gallogen (astringent); ELLAGIC ACID [WHO-DD]; Gallogen, astringent; Ellagic acid hydrate; tetrahydroxy[?]dione; ELLAGIC ACID [HSDB]; ELLAGIC ACID [INCI]; ELLAGIC ACID [INN]; Ellagic acid, 96\\%; ELLAGIC ACID [MI]; Pomegranate juice; Spectrum2_000905; BCBcMAP01_000154; Alizarine Yellow; Spectrum3_001535; Acidum ellagicum; Spectrum5_000959; Spectrum4_000750; Acid, Benzoaric; Alizarin yellow; UNII-19YRN3ZS9P; Acide ellagique; Tox21_110805_1; Benzoaric acid; Gallogen (VAN); Acido elagico; Oprea1_032884; Elleagic acid; Acid, Ellagic; KBio2_006810; Tox21_110805; Elagostasine; KBio2_001674; Ellagic Acid; ellagic-acid; NCI60_003869; KBio3_002450; KBio2_004242; Eleagic acid; SMP1_000111; Llagic acid; Ellagsaeure; Ellagicacid; Elagic Acid; Benzoarate; 19YRN3ZS9P; Lagistase; Eleagate; Gallogen; Ellagate; Llagate; Ellagic; LTK-20; 2zjw; REF; Ellagic acid



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(0)

PharmGKB(0)

1069 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hangjie Fu, Wenxia Li, Jinyuan Liu, Qiehao Tang, Zhiwei Weng, Lijian Zhu, Bin Ding. Ellagic acid inhibits dihydrotestosterone-induced ferroptosis and promotes hair regeneration by activating the wnt/β-catenin signaling pathway. Journal of ethnopharmacology. 2024 Aug; 330(?):118227. doi: 10.1016/j.jep.2024.118227. [PMID: 38685364]
  • Wei Gu, Ruolin Kong, Shuyang Qi, Xuxi Cheng, Xuyi Cai, Ziyun Zhou, Shunan Zhang, Hongyu Zhao, Jinyun Song, Qinglian Hu, Huiwen Yu, Huangjin Tong, Yiwei Wang, Tulin Lu. Sono-assembly of ellagic acid into nanostructures significantly enhances aqueous solubility and bioavailability. Food chemistry. 2024 Jun; 442(?):138485. doi: 10.1016/j.foodchem.2024.138485. [PMID: 38278106]
  • Nariman Ali Abdelrahim, Marina Noshy Saad, Martina Ashraf Zaghloul, Ossama Samueal Neaz. Assessing the anti-collagenase activity and phytochemical evaluation of eight plants cultivated in Egypt; developing a validation method for the ellagic acid content in Chrysophyllum oliviforme using HPLC-DAD. Natural product research. 2024 Jun; 38(11):1929-1937. doi: 10.1080/14786419.2023.2223737. [PMID: 37322870]
  • Yassmin Raafat Hassan, Riham A El-Shiekh, Hala Mohamed El Hefnawy, Camilia George Michael. Irvingia gabonensis baill. (African Mango): A comprehensive review of its ethnopharmacological significance, unveiling its long-standing history and therapeutic potential. Journal of ethnopharmacology. 2024 May; 326(?):117942. doi: 10.1016/j.jep.2024.117942. [PMID: 38395180]
  • Jinchao Wei, Renjian Xu, Yuanyuan Zhang, Lingyu Zhao, Shumu Li, Zhenwen Zhao. Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-High-Resolution Mass Spectrometry for Distinguishing the Origin of Ellagic Acid Extracts: Pomegranate Peels or Gallnuts. Molecules (Basel, Switzerland). 2024 Jan; 29(3):. doi: 10.3390/molecules29030666. [PMID: 38338410]
  • Lei Mao, Lingying Jiang, Hangyu Zhao, Jie Lin, Lihong Huang, Zebei Liu, Qunan Cheng, Xiaoyan Dai, Xiaofen Wang. A validated high-performance liquid chromatography method for detecting geniposide, ellagic acid, piperine, costunolide and dehydrocostus lactone in Liuwei Muxiang capsules. Pakistan journal of pharmaceutical sciences. 2024 Jan; 37(1(Special)):205-213. doi: ". [PMID: 38747271]
  • Shuaijun Lu, Hailong Tian, Bowen Li, Lei Li, Hao Jiang, Yajie Gao, Lin Zheng, Canhua Huang, Yuping Zhou, Zhongyan Du, Jia Xu. An Ellagic Acid Coordinated Copper-Based Nanoplatform for Efficiently Overcoming Cancer Chemoresistance by Cuproptosis and Synergistic Inhibition of Cancer Cell Stemness. Small (Weinheim an der Bergstrasse, Germany). 2023 Dec; ?(?):e2309215. doi: 10.1002/smll.202309215. [PMID: 38044295]
  • Luis Ângelo Macêdo Santiago, Ana Caroline Santos Ataíde, Danilo de Araújo Morais, Aldilene da Silva Lima, Nathálya Dos Santos Martins, Adriana Vivian Costa Araújo Dourado, Rachel Melo Ribeiro, Lídio Gonçalves Lima-Neto, Joicy Cortez de Sá Sousa, Cláudia Quintino da Rocha, Maria do Socorro de Sousa Cartágenes, Rafael Cardoso Carvalho, Eduardo Martins de Sousa. Bixa orellana ethyl acetate fraction and its isolated compound ellagic acid attenuate the progression of MIA-induced osteoarthritis in rat knees. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 168(?):115644. doi: 10.1016/j.biopha.2023.115644. [PMID: 37839112]
  • Carlos Eduardo Iglesias-Aguirre, María Romo-Vaquero, María Victoria Selma, Juan Carlos Espín. Unveiling metabotype clustering in resveratrol, daidzein, and ellagic acid metabolism: Prevalence, associated gut microbiomes, and their distinctive microbial networks. Food research international (Ottawa, Ont.). 2023 Nov; 173(Pt 2):113470. doi: 10.1016/j.foodres.2023.113470. [PMID: 37803793]
  • Jialuan Wang, Fengyi Zhao, Wenlong Wu, Lianfei Lyu, Weilin Li, Chunhong Zhang. Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity. International journal of molecular sciences. 2023 Oct; 24(20):. doi: 10.3390/ijms242015228. [PMID: 37894909]
  • Zhiyao Liu, Hailiang Huang, Ying Yu, Lingling Li, Xin Shi, Fangqi Wang. Exploring the mechanism of ellagic acid against gastric cancer based on bioinformatics analysis and network pharmacology. Journal of cellular and molecular medicine. 2023 Oct; ?(?):. doi: 10.1111/jcmm.17967. [PMID: 37794689]
  • Gugulethu P Khumalo, Thanh Nguyen, Ben-Erik Van Wyk, Yunjiang Feng, Ian E Cock. Inhibition of pro-inflammatory cytokines by selected southern African medicinal plants in LPS-stimulated RAW 264.7 macrophages. Journal of ethnopharmacology. 2023 Oct; 319(Pt 2):117268. doi: 10.1016/j.jep.2023.117268. [PMID: 37797874]
  • Yuyang Ye, Yuya Kawaguchi, Asahi Takeuchi, Ni Zhang, Ryosuke Mori, Maihemuti Mijiti, Arata Banno, Toshitaka Okada, Naoto Hiramatsu, Satoshi Nagaoka. Rose polyphenols exert antiobesity effect in high-fat-induced obese mice by regulating lipogenic gene expression. Nutrition research (New York, N.Y.). 2023 Sep; 119(?):76-89. doi: 10.1016/j.nutres.2023.09.002. [PMID: 37757642]
  • Puneet Arora, Evin T Magner, Paul L Bigliardi. Honey flower dermatitis: Contact allergy to ellagic acid in Melianthuscomosus. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Sep; 179(?):113956. doi: 10.1016/j.fct.2023.113956. [PMID: 37482193]
  • Dipak Biswas, Bharat Gopalrao Somkuwar, Jagat Chandra Borah, Pritish Kumar Varadwaj, Saurabh Gupta, Zeeshan Ahmad Khan, Gopinath Mondal, Asamanja Chattoraj, Lokesh Deb. Phytochemical mediated modulation of COX-3 and NFκB for the management and treatment of arthritis. Scientific reports. 2023 08; 13(1):13612. doi: 10.1038/s41598-023-37729-2. [PMID: 37604838]
  • Rakshandha Saini, Vikas Kumar, Chirag N Patel, Anuradha Sourirajan, Kamal Dev. Synergistic antibacterial activity of Phyllanthus emblica fruits and its phytocompounds with ampicillin: a computational and experimental study. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Jul; ?(?):. doi: 10.1007/s00210-023-02624-0. [PMID: 37522914]
  • Muxin Zheng, Shenghao Chen, Yi Liu, Yang He. α-Glucosidase inhibitory activities of constituents from Psidium guajava leaves. Natural product research. 2023 Jul; ?(?):1-4. doi: 10.1080/14786419.2023.2238113. [PMID: 37506309]
  • Jiahao Li, Xinxin Huang, Linjiao He, Chao Li, Hongxin Jing, Jianwei Lin, Chaoyu Ma, Xiaobin Li. Effect of ellagic acid on body weight, nutrient digestibility, fecal microbiota, and urolithin A metabolism in Thoroughbred horses. Journal of animal science. 2023 Jul; ?(?):. doi: 10.1093/jas/skad232. [PMID: 37422771]
  • Guangying Lu, Xuezhen Wang, Ming Cheng, Shijun Wang, Ke Ma. The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 165(?):115132. doi: 10.1016/j.biopha.2023.115132. [PMID: 37423169]
  • HaoSen Zhang, Jing Wang, Chaozhan Wang. Multi-target bioactive compound screening from the infructescence of Platycarya strobilacea Sieb. et Zucc. by affinity chromatography using immobilized β2 -adrenoceptor and muscarinic-3 acetylcholine receptor as the stationary phase. Journal of separation science. 2023 Jun; ?(?):e2300129. doi: 10.1002/jssc.202300129. [PMID: 37339788]
  • Anil Kumar Saini, Sultan Zahiruddin, Kakumani Godwin Newton, Laxman Sawant, Ranjan Mitra, Rajiva Kumar Rai, Sayeed Ahmad. Validation and standardization of Gallic acid and Ellagic acid in Quercus infectoria, Terminalia chebula and Pistacia integerrima. Journal of AOAC International. 2023 Jun; ?(?):. doi: 10.1093/jaoacint/qsad070. [PMID: 37294736]
  • Zixiang Wu, Lifang Hu, Kang Ru, Wenjuan Zhang, Xia Xu, Shuyu Liu, Hua Liu, Yunxia Jia, Shujing Liang, Zhihao Chen, Airong Qian. Ellagic acid inhibits CDK12 to increase osteoblast differentiation and alleviate osteoporosis in hindlimb-unloaded and ovariectomized mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jun; 114(?):154745. doi: 10.1016/j.phymed.2023.154745. [PMID: 36931096]
  • Adeola Oluwatosin Adedara, Titilayomi A Otenaike, Oluwabukola M Farodoye, Amos Olalekan Abolaji. Ellagic acid mitigates rotenone-induced damage via modulating mitochondria function in Drosophila melanogaster. Journal of biochemical and molecular toxicology. 2023 Jun; 37(6):e23332. doi: 10.1002/jbt.23332. [PMID: 37294177]
  • Yan-Hong Wang, Goutam Mondal, Washim Khan, Bill J Gurley, Charles R Yates. Development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for characterizing pomegranate extract pharmacokinetics in humans. Journal of pharmaceutical and biomedical analysis. 2023 May; 233(?):115477. doi: 10.1016/j.jpba.2023.115477. [PMID: 37267874]
  • Jingyan Li, Ruixue Liao, Shijia Zhang, Huimin Weng, Yuanzhi Liu, Tianyi Tao, Fengxu Yu, Guang Li, Jianming Wu. Promising remedies for cardiovascular disease: Natural polyphenol ellagic acid and its metabolite urolithins. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 May; 116(?):154867. doi: 10.1016/j.phymed.2023.154867. [PMID: 37257327]
  • Gabrielle Caroline Peiter, Thayene Kamyli Moesch Queiroz, Edson Luiz Michalkiewicz, Raphael Henrique Chappuis, Jennefer Sousa Luz, Luiz Henrique Casagrande Piovezani, Cleison Ferreira Silva, Matheus Nozomi Tsutumi, Augusto Fernandes Chaves, Rafael Messias Luiz, Cinthia Façanha Wendel, Ana Carla Zarpelon-Schutz, Kádima Nayara Teixeira. Lafoensia pacari alleviates intestinal damage by modulating cyclooxygenase-2: In silico and in vivo evaluation in a colitis model. World journal of gastroenterology. 2023 May; 29(17):2628-2641. doi: 10.3748/wjg.v29.i17.2628. [PMID: 37213402]
  • Tiziana Esposito, Simona Pisanti, Rosanna Martinelli, Rita Celano, Teresa Mencherini, Tania Re, Rita P Aquino. Couroupita guianensis bark decoction: From Amazonian medicine to the UHPLC-HRMS chemical profile and its role in inflammation processes and re-epithelialization. Journal of ethnopharmacology. 2023 May; ?(?):116579. doi: 10.1016/j.jep.2023.116579. [PMID: 37142146]
  • Jasmin Flemming, Clara Theres Meyer-Probst, Kristin Hille, Sabine Basche, Karl Speer, Isabelle Kölling-Speer, Christian Hannig, Matthias Hannig. Olive Oil as a Transport Medium for Bioactive Molecules of Plants?-An In Situ Study. Molecules (Basel, Switzerland). 2023 Apr; 28(9):. doi: 10.3390/molecules28093803. [PMID: 37175213]
  • Beatriz Soto-Huelin, Bohdan Babiy, Oscar Pastor, Mario Díaz-García, Ana Toledano-Zaragoza, María Dolores Frutos, Juan Carlos Espín, Francisco A Tomás-Barberán, Rebeca Busto, María Dolores Ledesma. Ellagic acid and its metabolites urolithins A/B ameliorate most common disease phenotypes in cellular and mouse models for lysosomal storage disorders by enhancing extracellular vesicle secretion. Neurobiology of disease. 2023 Apr; 182(?):106141. doi: 10.1016/j.nbd.2023.106141. [PMID: 37121555]
  • Ralitza Alexova, Simona Alexandrova, Stela Dragomanova, Reni Kalfin, Ayten Solak, Sidharth Mehan, Maria Cristina Petralia, Paolo Fagone, Katia Mangano, Ferdinando Nicoletti, Lyubka Tancheva. Anti-COVID-19 Potential of Ellagic Acid and Polyphenols of Punica granatum L. Molecules (Basel, Switzerland). 2023 Apr; 28(9):. doi: 10.3390/molecules28093772. [PMID: 37175181]
  • Yi Yang, Meihui Liu, Chang Liu, Shanshan Tang, Dongyu Gu, Jing Tian, Dezhi Huang, Fei He. Ellagic acid from pomegranate peel: consecutive counter-current chromatographic separation and antioxidant effect. Biomedical chromatography : BMC. 2023 Apr; ?(?):e5662. doi: 10.1002/bmc.5662. [PMID: 37185963]
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