(+)-taxifolin (BioDeep_00000000348)

 

Secondary id: BioDeep_00000017305, BioDeep_00000398609

natural product human metabolite PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-4-one

化学式: C15H12O7 (304.0583)
中文名称: 花旗松素, 二氢槲皮素, (+)-花旗松素
谱图信息: 最多检出来源 Viridiplantae(plant) 13.76%

分子结构信息

SMILES: c1(cc(c2c(c1)O[C@@H]([C@H](C2=O)O)c1cc(c(cc1)O)O)O)O
InChI: InChI=1/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1

描述信息

Taxifolin, also known as dihydroquercetin or (+)-taxifolin, is a member of the class of compounds known as flavanonols. Flavanonols are compounds containing a flavan-3-one moiety, with a structure characterized by a 2-phenyl-3,4-dihydro-2H-1-benzopyran bearing a hydroxyl group and a ketone at the carbon C2 and C3, respectively. Taxifolin is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Taxifolin can be found in a number of food items such as sweet rowanberry, arrowroot, evening primrose, and walnut, which makes taxifolin a potential biomarker for the consumption of these food products. Taxifolin is a flavanonol, a type of flavonoid .
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].
Taxifolin ((+)-Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].

同义名列表

32 个代谢物同义名

(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-1-benzopyran-4-one; (2R,3R)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one; (2R-trans)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4-benzopyrone; (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one; (2R,3R)-3,3’,4’,5,7-Pentahydroxyflavanone; (2R,3R)-3,3,4,5,7-Pentahydroxyflavanone; 3,5,7,3’,4’-Pentahydroxyflavanone; 3,5,7,3,4-Pentahydroxyflavanone; (+)-(2R,3R)-dihydroquercetin; 2,3-trans-Dihydroquercetin; (2R,3R)-Dihydroquercetin; trans-Dihydroquercetin; (2R,3R)-(+)-Taxifolin; 2,3-Dihydroquercetin; (±)-Taxifolin; (+)-Dihydroquercetin; (+)-trans-Taxifolin; (2R,3R)-Taxifolin; dihydroquercetin; (+-)-Taxifolin; (±)-Taxifolin; (+)-Taxifolin; Jikuberuchin; Taxifoliol; Flamena D; Taxifolin; Diquertin; Lariksin; Distylin; Lavitol; FLAMENA; Taxifolin



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

289 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(288)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

563 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ACE, AKT1, CAT, CTNNB1, MAPK14, MTOR, NFE2L2, NLRP3, NOS2, NQO1, PIK3CA, PTGS2, TP53, XDH
Peripheral membrane protein 2 MTOR, PTGS2
Endoplasmic reticulum membrane 3 HMOX1, MTOR, PTGS2
Nucleus 11 AKT1, CTNNB1, HMOX1, MAPK14, MPO, MTOR, NFE2L2, NLRP3, NOS2, NQO1, TP53
cytosol 14 AKT1, CAT, CTNNB1, GPT, HMOX1, MAPK14, MTOR, NFE2L2, NLRP3, NOS2, NQO1, PIK3CA, TP53, XDH
dendrite 2 MTOR, NQO1
phagocytic vesicle 1 MTOR
centrosome 3 CTNNB1, NFE2L2, TP53
nucleoplasm 9 AKT1, CTNNB1, HMOX1, MAPK14, MPO, MTOR, NFE2L2, NOS2, TP53
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 3 ACE, AKT1, CTNNB1
Cytoplasmic side 2 HMOX1, MTOR
lamellipodium 3 AKT1, CTNNB1, PIK3CA
Golgi apparatus membrane 2 MTOR, NLRP3
Synapse 2 CTNNB1, NQO1
cell cortex 2 AKT1, CTNNB1
cell junction 1 CTNNB1
glutamatergic synapse 3 AKT1, CTNNB1, MAPK14
Golgi apparatus 1 NFE2L2
Golgi membrane 2 MTOR, NLRP3
lysosomal membrane 1 MTOR
neuronal cell body 1 NQO1
postsynapse 1 AKT1
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 4 NFE2L2, NLRP3, NOS2, NQO1
Lysosome 3 ACE, MPO, MTOR
endosome 1 ACE
plasma membrane 6 ACE, AKT1, CTNNB1, NFE2L2, NOS2, PIK3CA
Membrane 9 ACE, AKT1, CAT, CTNNB1, HMOX1, MTOR, NLRP3, NQO1, TP53
axon 1 CCK
basolateral plasma membrane 1 CTNNB1
caveola 1 PTGS2
extracellular exosome 5 ACE, CAT, CTNNB1, GPT, MPO
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 HMOX1, NLRP3, PTGS2, TP53
extracellular space 7 ACE, CCK, HMOX1, IL10, IL6, MPO, XDH
perinuclear region of cytoplasm 4 CTNNB1, HMOX1, NOS2, PIK3CA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 4 CAT, MAPK14, NLRP3, TP53
protein-containing complex 5 AKT1, CAT, CTNNB1, PTGS2, TP53
intracellular membrane-bounded organelle 2 CAT, MPO
Microsome membrane 2 MTOR, PTGS2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 ACE
Secreted 5 ACE, CCK, IL10, IL6, NLRP3
extracellular region 8 ACE, CAT, CCK, IL10, IL6, MAPK14, MPO, NLRP3
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 2 HMOX1, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
transcription regulator complex 2 CTNNB1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
external side of plasma membrane 1 ACE
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 1 AKT1
nucleolus 1 TP53
Wnt signalosome 1 CTNNB1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
apical part of cell 1 CTNNB1
cell-cell junction 2 AKT1, CTNNB1
vesicle 1 AKT1
postsynaptic membrane 1 CTNNB1
Cytoplasm, perinuclear region 1 NOS2
Cytoplasm, cytoskeleton 2 CTNNB1, TP53
focal adhesion 2 CAT, CTNNB1
spindle 1 AKT1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Peroxisome 3 CAT, NOS2, XDH
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 MPO
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
nuclear speck 1 MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 2 NFE2L2, TP53
mediator complex 1 NFE2L2
cell periphery 1 CTNNB1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
brush border membrane 1 ACE
spindle pole 2 CTNNB1, MAPK14
sperm midpiece 1 ACE
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
site of double-strand break 1 TP53
nuclear envelope 1 MTOR
Endomembrane system 3 CTNNB1, MTOR, NLRP3
microtubule organizing center 1 NLRP3
euchromatin 1 CTNNB1
germ cell nucleus 1 TP53
replication fork 1 TP53
basal plasma membrane 1 ACE
azurophil granule 1 MPO
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 2 CAT, MAPK14
endoplasmic reticulum lumen 2 IL6, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
beta-catenin-TCF complex 1 CTNNB1
azurophil granule lumen 1 MPO
Single-pass type IV membrane protein 1 HMOX1
presynaptic active zone cytoplasmic component 1 CTNNB1
phagocytic vesicle lumen 1 MPO
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 2 CTNNB1, NFE2L2
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Qiteng Ding, Wencong Liu, Shuai Zhang, Shuwen Sun, Jiali Yang, Lifeng Zhang, Ning Wang, Shuang Ma, Guodong Chai, Liqian Shen, Yang Gao, Chuanbo Ding, Xinglong Liu. Hydrogel loaded with thiolated chitosan modified taxifolin liposome promotes osteoblast proliferation and regulates Wnt signaling pathway to repair rat skull defects. Carbohydrate polymers. 2024 Jul; 336(?):122115. doi: 10.1016/j.carbpol.2024.122115. [PMID: 38670750]
  • Marija Bruić, Andrea Pirković, Sunčica Borozan, Mirjana Nacka Aleksić, Milica Jovanović Krivokuća, Biljana Spremo-Potparević. Antioxidative and anti-inflammatory effects of taxifolin in H2O2-induced oxidative stress in HTR-8/SVneo trophoblast cell line. Reproductive toxicology (Elmsford, N.Y.). 2024 Jun; 126(?):108585. doi: 10.1016/j.reprotox.2024.108585. [PMID: 38574953]
  • Yuqiao Zeng, Yiyu He, Li Wang, Hao Xu, Qianwen Zhang, Yanjun Wang, Jianhua Zhang, Likun Wang. Dihydroquercetin improves experimental acute liver failure by targeting ferroptosis and mitochondria-mediated apoptosis through the SIRT1/p53 axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155533. doi: 10.1016/j.phymed.2024.155533. [PMID: 38552433]
  • Qiteng Ding, Xinglong Liu, Xuexia Liu, Guodong Chai, Ning Wang, Shuang Ma, Lifeng Zhang, Shuai Zhang, Jiali Yang, Yanjun Wang, Liqian Shen, Chuanbo Ding, Wencong Liu. Polyvinyl alcohol/carboxymethyl chitosan-based hydrogels loaded with taxifolin liposomes promote diabetic wound healing by inhibiting inflammation and regulating autophagy. International journal of biological macromolecules. 2024 Apr; 263(Pt 1):130226. doi: 10.1016/j.ijbiomac.2024.130226. [PMID: 38368971]
  • Yang Lu, Xinglong Liu, Ting Zhao, Chuanbo Ding, Qiteng Ding, Ning Wang, Shuang Ma, Lina Ma, Wencong Liu. Synthesis of Taxifolin-Loaded Polydopamine for Chemo-Photothermal-Synergistic Therapy of Ovarian Cancer. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29051042. [PMID: 38474556]
  • Ziyang Liu, Dengjun Qiu, Tong Yang, Jingxu Su, Chengyuan Liu, Xinyue Su, Anning Li, Pingping Sun, Jianguo Li, Li Yan, Chuanbo Ding, Shuai Zhang. Research Progress of Dihydroquercetin in the Treatment of Skin Diseases. Molecules (Basel, Switzerland). 2023 Oct; 28(19):. doi: 10.3390/molecules28196989. [PMID: 37836832]
  • Yue Wang, Chuanbo Ding, Yingchun Zhao, Jinping Zang, Qiteng Ding, Shuai Zhang, Ning Wang, Jiali Yang, Siyu Xi, Ting Zhao, Chunli Zhao, Wencong Liu. Sodium alginate/poly(vinyl alcohol)/taxifolin nanofiber mat promoting diabetic wound healing by modulating the inflammatory response, angiogenesis, and skin flora. International journal of biological macromolecules. 2023 Aug; ?(?):126530. doi: 10.1016/j.ijbiomac.2023.126530. [PMID: 37634780]
  • Amir Taldaev, Anastasiya D Savina, Vera V Olicheva, Sergey V Ivanov, Roman P Terekhov, Igor R Ilyasov, Anastasiya K Zhevlakova, Irina A Selivanova. Protective Properties of Spheroidal Taxifolin Form in Streptozotocin-Induced Diabetic Rats. International journal of molecular sciences. 2023 Jul; 24(15):. doi: 10.3390/ijms241511962. [PMID: 37569337]
  • Ipek Bayram, Artiona Laze, Eric A Decker. Synergistic Mechanisms of Interactions between Myricetin or Taxifolin with α-Tocopherol in Oil-in-Water Emulsions. Journal of agricultural and food chemistry. 2023 Jun; ?(?):. doi: 10.1021/acs.jafc.3c01226. [PMID: 37279160]
  • J N Caamaño, J Santiago-Moreno, F Martínez-Pastor, C Tamargo, A Salman, Á Fernández, M J Merino, E Lacalle, A Toledano-Díaz, C O Hidalgo. Use of the flavonoid taxifolin for sperm cryopreservation from the threatened Bermeya goat breed. Theriogenology. 2023 May; 206(?):18-27. doi: 10.1016/j.theriogenology.2023.05.004. [PMID: 37172535]
  • Qiteng Ding, Chuanbo Ding, Xinglong Liu, Yinan Zheng, Yingchun Zhao, Shuai Zhang, Shuwen Sun, Zanwen Peng, Wencong Liu. Preparation of nanocomposite membranes loaded with taxifolin liposome and its mechanism of wound healing in diabetic mice. International journal of biological macromolecules. 2023 Apr; 241(?):124537. doi: 10.1016/j.ijbiomac.2023.124537. [PMID: 37086765]
  • Shalini Gurumayum, Simanta Bharadwaj, Yunus Sheikh, Sagar R Barge, Kangkon Saikia, Deepsikha Swargiary, Semim Akhtar Ahmed, Debajit Thakur, Jagat C Borah. Taxifolin-3-O-glucoside from Osbeckia nepalensis Hook. mediates antihyperglycemic activity in CC1 hepatocytes and in diabetic Wistar rats via regulating AMPK/G6Pase/PEPCK signaling axis. Journal of ethnopharmacology. 2023 Mar; 303(?):115936. doi: 10.1016/j.jep.2022.115936. [PMID: 36403743]
  • Takayuki Inoue, Bin Fu, Miwako Nishio, Miyako Tanaka, Hisashi Kato, Masashi Tanaka, Michiko Itoh, Hajime Yamakage, Kozue Ochi, Ayaka Ito, Yukihiro Shiraki, Satoshi Saito, Masafumi Ihara, Hideo Nishimura, Atsuhiko Kawamoto, Shian Inoue, Kumiko Saeki, Atsushi Enomoto, Takayoshi Suganami, Noriko Satoh-Asahara. Novel Therapeutic Potentials of Taxifolin for Obesity-Induced Hepatic Steatosis, Fibrogenesis, and Tumorigenesis. Nutrients. 2023 Jan; 15(2):. doi: 10.3390/nu15020350. [PMID: 36678220]
  • A B Katasonov. [Dihydroquercetin as a systemic neuroprotector for the prevention and treatment of β-amyloid-associated brain diseases]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2023; 123(7):136-142. doi: 10.17116/jnevro2023123071136. [PMID: 37490679]
  • Mengyu Wang, Hui Han, Fan Wan, Ruqing Zhong, Yoon Jung Do, Sang-Ik Oh, Xuemeng Lu, Lei Liu, Bao Yi, Hongfu Zhang. Dihydroquercetin Supplementation Improved Hepatic Lipid Dysmetabolism Mediated by Gut Microbiota in High-Fat Diet (HFD)-Fed Mice. Nutrients. 2022 Dec; 14(24):. doi: 10.3390/nu14245214. [PMID: 36558373]
  • Jinping Zhang, Yongchun Zheng, Bo Hong, Lina Ma, Yingchun Zhao, Shuai Zhang, Shuwen Sun, Qiteng Ding, Yue Wang, Wencong Liu, Chuanbo Ding. Dihydroquercetin composite nanofibrous membrane prevents UVA radiation-mediated inflammation, apoptosis and oxidative stress by modulating MAPKs/Nrf2 signaling in human epidermal keratinocytes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Nov; 155(?):113727. doi: 10.1016/j.biopha.2022.113727. [PMID: 36156260]
  • Shiqin Yu, Mingjia Li, Song Gao, Jingwen Zhou. Engineering Saccharomyces cerevisiae for the production of dihydroquercetin from naringenin. Microbial cell factories. 2022 Oct; 21(1):213. doi: 10.1186/s12934-022-01937-8. [PMID: 36243863]
  • R Ozyurt, N Celik, Z Suleyman, F Cagiran, Z Kali, N Gurkan, F Altindag, S Bulut, C Sarigul, K Dinc, H Suleyman. Fertility protective effect of taxifolin in cisplatin-induced ovarian damage. European review for medical and pharmacological sciences. 2022 10; 26(19):7195-7203. doi: 10.26355/eurrev_202210_29909. [PMID: 36263529]
  • Mei-Hua Piao, Hui Wang, Yin-Jing Jiang, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian. Taxifolin blocks monosodium urate crystal-induced gouty inflammation by regulating phagocytosis and autophagy. Inflammopharmacology. 2022 Aug; 30(4):1335-1349. doi: 10.1007/s10787-022-01014-x. [PMID: 35708797]
  • Ying Li, Hang Su, Zhong-Ping Yin, Jing-En Li, En Yuan, Qing-Feng Zhang. Metabolism, tissue distribution and excretion of taxifolin in rat. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):112959. doi: 10.1016/j.biopha.2022.112959. [PMID: 35430392]
  • Jinping Zhang, Kecheng Chen, Chuanbo Ding, Shuwen Sun, Yinan Zheng, Qiteng Ding, Bo Hong, Wencong Liu. Fabrication of chitosan/PVP/dihydroquercetin nanocomposite film for in vitro and in vivo evaluation of wound healing. International journal of biological macromolecules. 2022 May; 206(?):591-604. doi: 10.1016/j.ijbiomac.2022.02.110. [PMID: 35217084]
  • Yiming Zhang, Lanlan Zhan, Quan Wen, Yulin Feng, Yun Luo, Ting Tan. Trapping Methylglyoxal by Taxifolin and Its Metabolites in Mice. Journal of agricultural and food chemistry. 2022 Apr; 70(16):5026-5038. doi: 10.1021/acs.jafc.2c02189. [PMID: 35420027]
  • Nguyen Huy Thuan, Anil Shrestha, Nguyen Thanh Trung, Vinay Bharadwaj Tatipamula, Duong Van Cuong, Nguyen Xuan Canh, Nguyen Van Giang, Tae-Su Kim, Jae Kyung Sohng, Dipesh Dhakal. Advances in biochemistry and the biotechnological production of taxifolin and its derivatives. Biotechnology and applied biochemistry. 2022 Apr; 69(2):848-861. doi: 10.1002/bab.2156. [PMID: 33797804]
  • Murat Alay, Miyase Gulcin Sonmez, Aysegul Sakin, Murat Atmaca, Halis Suleyman, Gulce Naz Yazici, Abdulkadir Coban, Bahadir Suleyman, Seval Bulut, Durdu Altuner. The effects of taxifolin on neuropathy related with hyperglycemia and neuropathic pain in rats: A biochemical and histopathological evaluation. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2022 Apr; 31(4):427-435. doi: 10.17219/acem/144002. [PMID: 35178903]
  • Hang Su, Wen-Jun Wang, Guo-Dong Zheng, Zhong-Ping Yin, Jing-En Li, Ling-Li Chen, Qing-Feng Zhang. The anti-obesity and gut microbiota modulating effects of taxifolin in C57BL/6J mice fed with a high-fat diet. Journal of the science of food and agriculture. 2022 Mar; 102(4):1598-1608. doi: 10.1002/jsfa.11496. [PMID: 34409603]
  • Wei Li, Le Zhang, Qingbiao Xu, Wenbo Yang, Jianan Zhao, Ying Ren, Zhendong Yu, Libao Ma. Taxifolin Alleviates DSS-Induced Ulcerative Colitis by Acting on Gut Microbiome to Produce Butyric Acid. Nutrients. 2022 Mar; 14(5):. doi: 10.3390/nu14051069. [PMID: 35268045]
  • Xiangming Liu, Yiming Ma, Lijuan Luo, Dandan Zong, Herui Li, Zihang Zeng, Yanan Cui, Weiwei Meng, Yan Chen. Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease by activating Nrf2-mediated pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Feb; 96(?):153894. doi: 10.1016/j.phymed.2021.153894. [PMID: 34942457]
  • Youhua Chen, Yan Mei, Lu Yang, Weibin Li, Yu Zhou, Surong He, Jie Liang. Taxifolin improves inflammatory injury of human bronchial epithelial cells by inhibiting matrix metalloproteinase (MMP) 10 via Wnt/β-catenin pathway. Bioengineered. 2022 01; 13(1):1198-1208. doi: 10.1080/21655979.2021.2018384. [PMID: 35000533]
  • Mengwen Shen, Baibai Lin, Fenghua Qian, Lei Zhao, Yao Xi, Yiming Qian. Taxifolin ameliorates sepsis-induced lung capillary leak through inhibiting the JAK/STAT3 pathway. Allergologia et immunopathologia. 2022; 50(2):7-15. doi: 10.15586/aei.v50i2.550. [PMID: 35257540]
  • Ceyda Tanoğlu, Alevtina Ersoy, Taha Abdulkadir Çoban, Gülce Naz Yazıcı, Renad Mammadov, Bahadır Süleyman. The effect of taxifolin on oxidative sciatic nerve damage induced by cobalt chloride in rats: a biochemical and histopathological evaluation. Acta neurobiologiae experimentalis. 2022; 82(3):254-262. doi: 10.55782/ane-2022-024. [PMID: 36214708]
  • Alena Rajnochová Svobodová, Alena Ryšavá, Kateřina Čížková, Lenka Roubalová, Jitka Ulrichová, Jiří Vrba, Bohumil Zálešák, Jitka Vostálová. Effect of the flavonoids quercetin and taxifolin on UVA-induced damage to human primary skin keratinocytes and fibroblasts. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2022 Jan; 21(1):59-75. doi: 10.1007/s43630-021-00140-9. [PMID: 34837635]
  • Xiaoying Yu, Saddam Hussein, Lijia Li, Qingyu Liu, Zhibin Ban, Hailong Jiang. Effect of Dihydroquercetin on Energy Metabolism in LPS-Induced Inflammatory Mice. BioMed research international. 2022; 2022(?):6491771. doi: 10.1155/2022/6491771. [PMID: 35832840]
  • Sahin Yuceli, Bahadir Suleyman, Gulce Naz Yazici, Renad Mammadov, Murat Cankaya, Celaleddin Semih Kunak, Seval Bulut, Halis Suleyman, Durdu Altuner. Effect of Taxifolin on Ischemia/Reperfusion-Induced Oxidative Injury of Sciatic Nerve in Rats. Transplantation proceedings. 2021 Dec; 53(10):3087-3092. doi: 10.1016/j.transproceed.2021.09.041. [PMID: 34772492]
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