Squalene (BioDeep_00000000829)

 

Secondary id: BioDeep_00000306012

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019 Volatile Flavor Compounds natural product


代谢物信息卡片


InChI=1/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24

化学式: C30H50 (410.39123)
中文名称: 角鲨烯, 鲨烯, （10E，14E，18E）-2,6,10,15,19,23-六甲基四环素-2,6,10,14,18,22-己烯, 全反-2,6,10,15,19,23-六甲基-2,6,10,14,18,22-廿四碳六烯
谱图信息: 最多检出来源 Homo sapiens(feces) 0.04%

分子结构信息

SMILES: C(C)(CCC=C(C)C)=CCC/C(/C)=C/CCC=C(C)CCC=C(C)CCC=C(C)C
InChI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+

描述信息

Squalene is an unsaturated aliphatic hydrocarbon (carotenoid) with six unconjugated double bonds found in human sebum (5\\\\%), fish liver oils, yeast lipids, and many vegetable oils (e.g. palm oil, cottonseed oil, rapeseed oil). Squalene is a volatile component of the scent material from Saguinus oedipus (cotton-top tamarin monkey) and Saguinus fuscicollis (saddle-back tamarin monkey) (Hawleys Condensed Chemical Reference). Squalene is a component of adult human sebum that is principally responsible for fixing fingerprints (ChemNetBase). It is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, though there are botanical sources as well, including rice bran, wheat germ, and olives. All higher organisms produce squalene, including humans. It is a hydrocarbon and a triterpene. Squalene is a biochemical precursor to the whole family of steroids. Oxidation of one of the terminal double bonds of squalene yields 2,3-squalene oxide which undergoes enzyme-catalyzed cyclization to afford lanosterol, which is then elaborated into cholesterol and other steroids. Squalene is a low-density compound often stored in the bodies of cartilaginous fishes such as sharks, which lack a swim bladder and must therefore reduce their body density with fats and oils. Squalene, which is stored mainly in the sharks liver, is lighter than water with a specific gravity of 0.855 (Wikipedia) Squalene is used as a bactericide. It is also an intermediate in the manufacture of pharmaceuticals, rubber chemicals, and colouring materials (Physical Constants of Chemical Substances).
Trans-squalene is a clear, slightly yellow liquid with a faint odor. Density 0.858 g / cm3.
Squalene is a triterpene consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration. It has a role as a human metabolite, a plant metabolite, a Saccharomyces cerevisiae metabolite and a mouse metabolite.
Squalene is originally obtained from shark liver oil. It is a natural 30-carbon isoprenoid compound and intermediate metabolite in the synthesis of cholesterol. It is not susceptible to lipid peroxidation and provides skin protection. It is ubiquitously distributed in human tissues where it is transported in serum generally in association with very low density lipoproteins. Squalene is investigated as an adjunctive cancer therapy.
Squalene is a natural product found in Ficus septica, Garcinia multiflora, and other organisms with data available.
squalene is a metabolite found in or produced by Saccharomyces cerevisiae.
A natural 30-carbon triterpene.
See also: Olive Oil (part of); Shark Liver Oil (part of).
A triterpene consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration.
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Squalene is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, cardioprotective, antioxidant, and antitoxicant activity. Squalene also has anti-fungal activity and can be used for the research of Trichophyton mentagrophytes research[2].
Squalene is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, cardioprotective, antioxidant, and antitoxicant activity. Squalene also has anti-fungal activity and can be used for the research of Trichophyton mentagrophytes research[2].

同义名列表

47 个代谢物同义名

InChI=1/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24; 2,6,10,15,19,23-Hexamethyltetracosa-(2E,6E,10E,14E,18E,22E)-2,6,10,14,18,22-hexaene; 2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (2E,6E,10E,14E,18E)-; 2,6,10,14,18,22-tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (6E,10E,14E,18E)-; (2E,6E,10E,14E,18E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene; (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene; 2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (all-E)-; 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene, (all-E)-; 2,6,10,14,18,22-Tetracosahexene, 2,6,10,15,19,23-hexamethyl-,(all-E)-; (All-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene; 2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-; 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetra cosahexaene; 2,6,10,15,19,23-Hexamethyltetracosa-2,6,10,14,18,22-hexaene; 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene; Super Squalene; trans-Squalene;AddaVax; Squalene, Spinacene, Supraene; SQUALENE (EP MONOGRAPH); SQUALENE [EP MONOGRAPH]; MF59 COMPONENT SQUALENE; SQUALENE [GREEN BOOK]; Squalene, all-trans-; All-trans-Squalene; (E,E,E,E)-Squalene; SQUALENE [WHO-DD]; Nikko Squalane EX; SQUALENE [INCI]; UNII-7QWM220FJH; trans-Spinacene; (E/Z)-Squalene; Super Squalene; trans-Squalene; SQUALENE [MI]; Tox21_112789; Tox21_113239; (E)-Squalene; 7QWM220FJH; Spinacene; squalcnc; Squalene; Spinacen; Supraene; AddaVax; Squalen; MF59; (6Z,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene; (10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene; Squalene



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(10)

PlantCyc(3)

代谢反应

936 个相关的代谢反应过程信息。

Reactome(60)

BioCyc(23)

WikiPathways(5)

Plant Reactome(532)

INOH(2)

PlantCyc(255)

COVID-19 Disease Map(1)

PathBank(58)

PharmGKB(0)

817 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jiin Felgner, Elizabeth Clarke, Jenny E Hernandez-Davies, Sharon Jan, Ariel S Wirchnianski, Aarti Jain, Rie Nakajima, Algimantas Jasinskas, Erwin Strahsburger, Kartik Chandran, Steven Bradfute, D Huw Davies. Broad antibody and T cell responses to Ebola, Sudan, and Bundibugyo ebolaviruses using mono- and multi-valent adjuvanted glycoprotein vaccines. Antiviral research. 2024 May; 225(?):105851. doi: 10.1016/j.antiviral.2024.105851. [PMID: 38458540]
  • Man Xu, Nan Yang, Jiang Pan, Qiang Hua, Chun-Xiu Li, Jian-He Xu. Remodeling the Homologous Recombination Mechanism of Yarrowia lipolytica for High-Level Biosynthesis of Squalene. Journal of agricultural and food chemistry. 2024 May; 72(17):9984-9993. doi: 10.1021/acs.jafc.4c01779. [PMID: 38635942]
  • Xiao-Bo Li, Chun-Li Huang, Ying Zhang, Jing-Yang Ding, Gui-Sheng Xiang, Guang-Hui Zhang, Sheng-Chao Yang, Bing Hao. Promiscuous Oxidosqualene Cyclases from Neoalsomitra integrifoliola Catalyzing the Formation of Tetracyclic, Pentacyclic, and Heterocyclic Triterpenes. Organic letters. 2024 Apr; 26(15):3119-3123. doi: 10.1021/acs.orglett.4c00730. [PMID: 38588021]
  • Lilit Grigoryan, Yupeng Feng, Lorenza Bellusci, Lilin Lai, Bushra Wali, Madison Ellis, Meng Yuan, Prabhu S Arunachalam, Mengyun Hu, Sangeeta Kowli, Sheena Gupta, Sofia Maysel-Auslender, Holden T Maecker, Hady Samaha, Nadine Rouphael, Ian A Wilson, Alberto C Moreno, Mehul S Suthar, Surender Khurana, Stéphane Pillet, Nathalie Charland, Brian J Ward, Bali Pulendran. AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans. Science immunology. 2024 Apr; 9(94):eadi8039. doi: 10.1126/sciimmunol.adi8039. [PMID: 38579013]
  • Jamila Gagour, Otmane Hallouch, Abderrahim Asbbane, Laila Bijla, Abdellatif Laknifli, Learn-Han Lee, Gokhan Zengin, Abdelhakim Bouyahya, El Hassan Sakar, Said Gharby. A Review of Recent Progresses on Olive Oil Chemical Profiling, Extraction Technology, Shelf-life, and Quality Control. Chemistry & biodiversity. 2024 Apr; 21(4):e202301697. doi: 10.1002/cbdv.202301697. [PMID: 38345352]
  • Yue Zhang, Zuchen Song, Zhimin Zhang, Tao Zhang, Pengfei Gu, Zian Feng, Shuwen Xu, Yang Yang, Deyun Wang, Zhenguang Liu. Preparation and characterization of pickering emulsion stabilized by lovastatin nanoparticles for vaccine adjuvants. International journal of pharmaceutics. 2024 Mar; 653(?):123901. doi: 10.1016/j.ijpharm.2024.123901. [PMID: 38368969]
  • Yang Ning, Mengsu Liu, Ziyun Ru, Weizhu Zeng, Song Liu, Jingwen Zhou. Efficient synthesis of squalene by cytoplasmic-peroxisomal engineering and regulating lipid metabolism in Yarrowia lipolytica. Bioresource technology. 2024 Mar; 395(?):130379. doi: 10.1016/j.biortech.2024.130379. [PMID: 38281547]
  • Bhawana Mishra, Shilpi Bansal, Sandhya Tripathi, Smrati Mishra, Ritesh K Yadav, Neelam S Sangwan. Differential regulation of key triterpene synthase gene under abiotic stress in Withania somnifera L. Dunal and its co-relation to sterols and withanolides. Plant physiology and biochemistry : PPB. 2024 Mar; 208(?):108419. doi: 10.1016/j.plaphy.2024.108419. [PMID: 38377888]
  • Chikara Kato, Ibuki Kusumoto, Shunji Kato, Yurika Otoki, Junya Ito, Hirono Totsuka, Arun Rajgopal, Jina Hong, Kiyotaka Nakagawa. Induction of ferroptosis in human keratinocyte HaCaT cells by squalene hydroperoxide: Possible prevention of skin ferroptosis by botanical extracts. Biochemical and biophysical research communications. 2024 Feb; 698(?):149553. doi: 10.1016/j.bbrc.2024.149553. [PMID: 38271833]
  • Sung Chul Park, Breanne N Steffan, Fang Yun Lim, Raveena Gupta, Fatma Ayaloglu Butun, Hongyu Chen, Rosa Ye, Timothy Decker, Chengcang C Wu, Neil L Kelleher, Jin Woo Bok, Nancy P Keller. Terpenoid balance in Aspergillus nidulans unveiled by heterologous squalene synthase expression. Science advances. 2024 Feb; 10(8):eadk7416. doi: 10.1126/sciadv.adk7416. [PMID: 38381828]
  • Yongshuo Ma, Yi Shang, Gregory Stephanopoulos. Engineering peroxisomal biosynthetic pathways for maximization of triterpene production in Yarrowia lipolytica. Proceedings of the National Academy of Sciences of the United States of America. 2024 Jan; 121(5):e2314798121. doi: 10.1073/pnas.2314798121. [PMID: 38261612]
  • Shuang-Yan Zhang, Yu-Qing Peng, Gui-Sheng Xiang, Wan-Ling Song, Lei Feng, Xin-Yue Jiang, Xue-Jiao Li, Si-Mei He, Sheng-Chao Yang, Yan Zhao, Guang-Hui Zhang. Functional characterization of genes related to triterpene and flavonoid biosynthesis in Cyclocarya paliurus. Planta. 2024 Jan; 259(2):50. doi: 10.1007/s00425-023-04282-1. [PMID: 38285114]
  • Xiao-Liu Liu, Jing Xie, Zhen-Ni Xie, Can Zhong, Hao Liu, Shui-Han Zhang, Jian Jin. Identification of squalene epoxidase in triterpenes biosynthesis in Poria cocos by molecular docking and CRISPR-Cas9 gene editing. Microbial cell factories. 2024 Jan; 23(1):34. doi: 10.1186/s12934-024-02306-3. [PMID: 38273342]
  • Paweł Paśko, Agnieszka Galanty, Emilia Ramos-Zambrano, Alma Leticia Martinez Ayala, Efren Delgado, Joanna Gdula- Argasińska, Paweł Zagrodzki, Robert Podsiadły, Joseph Deutsch, Shela Gorinstein. Pseudocereal Oils, Authenticated by Fourier Transform Infrared Spectroscopy, and their Chemopreventive Properties. Plant foods for human nutrition (Dordrecht, Netherlands). 2024 Jan; ?(?):. doi: 10.1007/s11130-024-01139-0. [PMID: 38231454]
  • Jing-Jing Zhang, Yan Gao, Xiao Xu, Mei-Ling Zhao, Bo-Nan Xi, Yu Shu, Cong Li, Yehua Shen. In Situ Rapid Analysis of Squalene, Tocopherols, and Sterols in Walnut Oils Based on Supercritical Fluid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry. Journal of agricultural and food chemistry. 2023 Nov; 71(43):16371-16380. doi: 10.1021/acs.jafc.3c05857. [PMID: 37867462]
  • Javier Sánchez-Marco, Seyed Hesamoddin Bidooki, Roubi Abuobeid, Cristina Barranquero, Tania Herrero-Continente, Carmen Arnal, Roberto Martínez-Beamonte, Roberto Lasheras, Joaquín C Surra, María A Navarro, María J Rodríguez-Yoldi, Manuel Arruebo, Victor Sebastian, Jesús Osada. Thioredoxin domain containing 5 is involved in the hepatic storage of squalene into lipid droplets in a sex-specific way. The Journal of nutritional biochemistry. 2023 Oct; ?(?):109503. doi: 10.1016/j.jnutbio.2023.109503. [PMID: 37898391]
  • M Luisa Hernández, Cristina Muñoz-Ocaña, Pilar Posada, M Dolores Sicardo, Dámaso Hornero-Méndez, Raquel B Gómez-Coca, Angjelina Belaj, Wenceslao Moreda, José M Martínez-Rivas. Functional Characterization of Four Olive Squalene Synthases with Respect to the Squalene Content of the Virgin Olive Oil. Journal of agricultural and food chemistry. 2023 Oct; 71(42):15701-15712. doi: 10.1021/acs.jafc.3c05322. [PMID: 37815987]
  • Maria Breygina, Dmitry Kochkin, Alexander Voronkov, Tatiana Ivanova, Ksenia Babushkina, Ekaterina Klimenko. Plant Hormone and Fatty Acid Screening of Nicotiana tabacum and Lilium longiflorum Stigma Exudates. Biomolecules. 2023 08; 13(9):. doi: 10.3390/biom13091313. [PMID: 37759713]
  • Josephine G LoRicco, Ingo Hoffmann, Antonino Caliò, Judith Peters. The membrane regulator squalane increases membrane rigidity under high hydrostatic pressure in archaeal membrane mimics. Soft matter. 2023 Aug; 19(33):6280-6286. doi: 10.1039/d3sm00352c. [PMID: 37553974]
  • Jinling Li, Shuai Wang, Yinan Miao, Ya Wan, Chun Li, Ying Wang. Mining and modification of Oryza sativa-derived squalene epoxidase for improved β-amyrin production in Saccharomyces cerevisiae. Journal of biotechnology. 2023 Aug; 375(?):1-11. doi: 10.1016/j.jbiotec.2023.08.004. [PMID: 37597655]
  • Roubi Abuobeid, Luis V Herrera-Marcos, Carmen Arnal, Seyed Hesamoddin Bidooki, Javier Sánchez-Marco, Roberto Lasheras, Joaquín C Surra, María Jesús Rodríguez-Yoldi, Roberto Martínez-Beamonte, Jesús Osada. Differentially Expressed Genes in Response to a Squalene-Supplemented Diet Are Accurate Discriminants of Porcine Non-Alcoholic Steatohepatitis. International journal of molecular sciences. 2023 Aug; 24(16):. doi: 10.3390/ijms241612552. [PMID: 37628732]
  • Carl Recsei, Robert A Russell, Marina Cagnes, Tamim Darwish. Deuterated squalene and sterols from modified Saccharomyces cerevisiae. Organic & biomolecular chemistry. 2023 Jul; ?(?):. doi: 10.1039/d3ob00754e. [PMID: 37523212]
  • Ana Guadalupe Fracchia-Durán, Emilia Ramos-Zambrano, Facundo Joaquín Márquez-Rocha, Alma Leticia Martínez-Ayala. Bioprocess conditions and regulation factors to optimize squalene production in thraustochytrids. World journal of microbiology & biotechnology. 2023 Jul; 39(9):251. doi: 10.1007/s11274-023-03689-y. [PMID: 37442840]
  • Fan Zhang, Yunpeng Wang, Jingyang Yue, Rongrong Zhang, Yong-Er Hu, Ruoshi Huang, Ai-Jia Ji, B Andes Hess, Zhongqiu Liu, Lixin Duan, Ruibo Wu. Discovering a uniform functional trade-off of the CBC-type 2,3-oxidosqualene cyclases and deciphering its chemical logic. Science advances. 2023 06; 9(23):eadh1418. doi: 10.1126/sciadv.adh1418. [PMID: 37285431]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Anna Grygier, Suryakant Chakradhari, Katarzyna Ratusz, Magdalena Rudzińska, Khageshwar Singh Patel, Danija Lazdiņa, Dalija Segliņa, Paweł Górnaś. Evaluation of Selected Medicinal, Timber and Ornamental Legume Species' Seed Oils as Sources of Bioactive Lipophilic Compounds. Molecules (Basel, Switzerland). 2023 May; 28(10):. doi: 10.3390/molecules28103994. [PMID: 37241735]
  • Tri Widyawati, Rony Abdi Syahputra, Siti Syarifah, Imam Bagus Sumantri. Analysis of Antidiabetic Activity of Squalene via In Silico and In Vivo Assay. Molecules (Basel, Switzerland). 2023 Apr; 28(9):. doi: 10.3390/molecules28093783. [PMID: 37175192]
  • Yunliang Zhang, Weigao Wang, Wenqian Wei, Lu Xia, Song Gao, Weizhu Zeng, Song Liu, Jingwen Zhou. Regulation of Ethanol Assimilation for Efficient Accumulation of Squalene in Saccharomyces cerevisiae. Journal of agricultural and food chemistry. 2023 Apr; 71(16):6389-6397. doi: 10.1021/acs.jafc.3c00515. [PMID: 37052370]
  • Ana Belen Moraleda Merlo, Claude Roux, Andy Bécue, Céline Weyermann. A comparison of the natural and groomed fingermark lipid composition of different donors using GC/MS. Forensic science international. 2023 Apr; ?(?):111709. doi: 10.1016/j.forsciint.2023.111709. [PMID: 37149490]
  • Yangmiao Jiao, Xu Li, Xueshuang Huang, Fan Liu, Zaiqi Zhang, Liang Cao. The Identification of SQS/SQE/OSC Gene Families in Regulating the Biosynthesis of Triterpenes in Potentilla anserina. Molecules (Basel, Switzerland). 2023 Mar; 28(6):. doi: 10.3390/molecules28062782. [PMID: 36985754]
  • Shuai Wang, Yumei Feng, Yin Lou, Jingping Niu, Congcong Yin, Jinzhong Zhao, Weijun Du, Aiqin Yue. 3-Hydroxy-3-methylglutaryl coenzyme A reductase genes from Glycine max regulate plant growth and isoprenoid biosynthesis. Scientific reports. 2023 03; 13(1):3902. doi: 10.1038/s41598-023-30797-4. [PMID: 36890158]
  • Hidayat Hussain, Jianbo Xiao, Akbar Ali, Ivan R Green, Bernhard Westermann. Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis. Natural product reports. 2023 Feb; 40(2):412-451. doi: 10.1039/d2np00033d. [PMID: 36458822]
  • Thomas R Henson, Katherine A Richards, Siva K Gandhapudi, Jerold G Woodward, Andrea J Sant. R-DOTAP Cationic Lipid Nanoparticles Outperform Squalene-Based Adjuvant Systems in Elicitation of CD4 T Cells after Recombinant Influenza Hemagglutinin Vaccination. Viruses. 2023 Feb; 15(2):. doi: 10.3390/v15020538. [PMID: 36851752]
  • Frédéric Lirussi, Kyrylo Pyrshev, Semen Yesylevskyy, Timothée Rivel, Tatiana Lopez, Eleonore Coppens, Simona Mura, Patrick Couvreur, Christophe Ramseyer. Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells. Biochimica et biophysica acta. Molecular basis of disease. 2023 02; 1869(2):166614. doi: 10.1016/j.bbadis.2022.166614. [PMID: 36494037]
  • Luis V Herrera-Marcos, Roberto Martínez-Beamonte, Carmen Arnal, Cristina Barranquero, Juan J Puente-Lanzarote, Tania Herrero-Continente, José M Lou-Bonafonte, Gonzalo Gonzalo-Romeo, Gabriele Mocciaro, Benjamin Jenkins, Joaquín C Surra, María J Rodríguez-Yoldi, Juan Carlos Burillo, Roberto Lasheras, Agustín García-Gil, Antonio Güemes, Albert Koulman, Jesús Osada. Dietary squalene supplementation decreases triglyceride species and modifies phospholipid lipidomic profile in the liver of a porcine model of non-alcoholic steatohepatitis. The Journal of nutritional biochemistry. 2023 02; 112(?):109207. doi: 10.1016/j.jnutbio.2022.109207. [PMID: 36402249]
  • Zexiao Fan, Yue Zhang, Lina Jiao, Tianyu Zhu, Zian Feng, Zhenguang Liu, Yang Yang, Deyun Wang. Lycium barbarum polysaccharides-loaded Particulate Alum via Pickering emulsion as an adjuvant to enhance immune responses. International journal of pharmaceutics. 2023 Jan; 630(?):122418. doi: 10.1016/j.ijpharm.2022.122418. [PMID: 36423709]
  • Yuya Yoshioka, Kouji Kobiyama, Tomoya Hayashi, Motoyasu Onishi, Yosuke Yanagida, Takayuki Nakagawa, Masayuki Hashimoto, Anri Nishinaka, Jun Hirose, Yoshiji Asaoka, Minako Tajiri, Atsushi Hayata, Satoru Ishida, Shinya Omoto, Morio Nagira, Ken J Ishii. A-910823, a squalene-based emulsion adjuvant, induces T follicular helper cells and humoral immune responses via α-tocopherol component. Frontiers in immunology. 2023; 14(?):1116238. doi: 10.3389/fimmu.2023.1116238. [PMID: 36891311]
  • Ying-Shuang Xu, Wang Ma, Jin Li, Peng-Wei Huang, Xiao-Man Sun, He Huang. Metal cofactor regulation combined with rational genetic engineering of Schizochytrium sp. for high-yield production of squalene. Biotechnology and bioengineering. 2022 Dec; ?(?):. doi: 10.1002/bit.28311. [PMID: 36522292]
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