Squalene (BioDeep_00000306012)

Main id: BioDeep_00000000829

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019 natural product


代谢物信息卡片


InChI=1\C30H50\c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4\h15-18,23-24H,9-14,19-22H2,1-8H3\b27-17+,28-18+,29-23+,30-24

化学式: C30H50 (410.3912)
中文名称: 角鲨烯, （10E，14E，18E）-2,6,10,15,19,23-六甲基四环素-2,6,10,14,18,22-己烯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C
InChI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+

描述信息

Squalene, also known as (e,e,e,e)-squalene or all-trans-squalene, is a member of the class of compounds known as triterpenoids. Triterpenoids are terpene molecules containing six isoprene units. Squalene can be found in a number of food items such as apricot, savoy cabbage, peach (variety), and bitter gourd, which makes squalene a potential biomarker for the consumption of these food products. Squalene can be found primarily in blood, feces, and sweat, as well as throughout most human tissues. In humans, squalene is involved in several metabolic pathways, some of which include risedronate action pathway, steroid biosynthesis, alendronate action pathway, and fluvastatin action pathway. Squalene is also involved in several metabolic disorders, some of which include cholesteryl ester storage disease, CHILD syndrome, hyper-igd syndrome, and wolman disease. Squalene is a natural 30-carbon organic compound originally obtained for commercial purposes primarily from shark liver oil (hence its name, as Squalus is a genus of sharks), although plant sources (primarily vegetable oils) are now used as well, including amaranth seed, rice bran, wheat germ, and olives. Yeast cells have been genetically engineered to produce commercially useful quantities of "synthetic" squalene .
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Window width to select the precursor ion was 3 Da.; CONE_VOLTAGE was 20 V.; This record was created by the financial support of MEXT/JSPS KAKENHI Grant Number 19HP8024 to the Mass Spectrometry Society of Japan.
Squalene is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, cardioprotective, antioxidant, and antitoxicant activity. Squalene also has anti-fungal activity and can be used for the research of Trichophyton mentagrophytes research[2].
Squalene is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, cardioprotective, antioxidant, and antitoxicant activity. Squalene also has anti-fungal activity and can be used for the research of Trichophyton mentagrophytes research[2].

同义名列表

36 个代谢物同义名

Squalene; (6Z,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene; InChI=1\C30H50\c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4\h15-18,23-24H,9-14,19-22H2,1-8H3\b27-17+,28-18+,29-23+,30-24; 2,6,10,15,19,23-Hexamethyltetracosa-(2E,6E,10E,14E,18E,22E)-2,6,10,14,18,22-hexaene; 2,6,10,14,18,22-tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (6E,10E,14E,18E)-; (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene; 2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (all-E)-; (All-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene; (14E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene; 2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-,; 2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-; 2,6,10,15,19,23-Hexamethyltetracosa-2,6,10,14,18,22-hexaene; 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene; Squalene, Spinacene, Supraene; All-trans-Squalene; (E,E,E,E)-Squalene; EINECS 203-826-1; 442785_SUPELCO; trans-Squalene; LMPR01060008; S3626_SIGMA; CHEBI:15440; AIDS-017396; AIDS017396; 94016-35-0; Spinacene; CCRIS 711; 7683-64-9; 111-02-4; NSC93748; Supraene; C00751; Super Squalene; AddaVax; Squalene; (10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene



数据库引用编号

29 个数据库交叉引用编号

分类词条

833 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 APOE, CAT, FDPS, HPGDS, SHC1, TLR4
Peripheral membrane protein 3 CYP1B1, ERVW-1, SQLE
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 5 CD4, CYP1B1, FDFT1, HMGCR, SQLE
Nucleus 1 APOE
cytosol 4 CAT, FDPS, HPGDS, SHC1
dendrite 1 APOE
nucleoplasm 2 FDPS, HPGDS
Cell membrane 5 CD4, CD79A, CD8A, TLR4, TNF
Multi-pass membrane protein 2 FDFT1, HMGCR
cell surface 2 TLR4, TNF
glutamatergic synapse 1 APOE
Golgi apparatus 1 APOE
Golgi membrane 1 INS
neuronal cell body 2 APOE, TNF
plasma membrane 9 APOE, CD4, CD79A, CD8A, ERVW-1, IFNLR1, SHC1, TLR4, TNF
Membrane 9 APOE, CAT, CYP1B1, FDFT1, FDPS, HMGCR, IFNLR1, SQLE, TLR4
extracellular exosome 2 APOE, CAT
endoplasmic reticulum 4 APOE, FDFT1, HMGCR, SQLE
extracellular space 6 APOE, IL2, IL4, IL6, INS, TNF
perinuclear region of cytoplasm 1 TLR4
mitochondrion 2 CAT, CYP1B1
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 4 CAT, CYP1B1, HPGDS, SQLE
Microsome membrane 2 CYP1B1, SQLE
Single-pass type I membrane protein 6 CD4, CD79A, CD8A, ERVW-1, IFNLR1, TLR4
Secreted 5 APOE, IL2, IL4, IL6, INS
extracellular region 8 APOE, CAT, CD8A, IL2, IL4, IL6, INS, TNF
[Isoform 2]: Secreted 1 CD8A
mitochondrial matrix 3 CAT, FDPS, SHC1
external side of plasma membrane 5 CD4, CD79A, CD8A, TLR4, TNF
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 2 APOE, CD79A
very-low-density lipoprotein particle 1 APOE
Early endosome 3 APOE, CD4, TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 3 CD4, CD79A, TNF
Cell junction, focal adhesion 1 SHC1
focal adhesion 2 CAT, SHC1
extracellular matrix 1 APOE
Peroxisome 2 CAT, FDPS
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 2 CAT, HMGCR
collagen-containing extracellular matrix 1 APOE
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 CD8A, TLR4
phagocytic cup 2 TLR4, TNF
Secreted, extracellular space 1 APOE
blood microparticle 1 APOE
endosome lumen 1 INS
Melanosome 1 APOE
Peroxisome membrane 1 HMGCR
lipopolysaccharide receptor complex 1 TLR4
plasma membrane raft 1 CD8A
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 APOE, CD4, IL6, INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 2 APOE, CD4
synaptic cleft 1 APOE
[Transmembrane protein]: Cell membrane 1 ERVW-1
[Surface protein]: Cell membrane 1 ERVW-1
[Isoform 1]: Cell membrane 1 CD8A
discoidal high-density lipoprotein particle 1 APOE
Shc-EGFR complex 1 SHC1
endocytic vesicle lumen 1 APOE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 2 CD4, CD8A
IgM B cell receptor complex 1 CD79A
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
B cell receptor complex 1 CD79A
[Isoform p46Shc]: Mitochondrion matrix 1 SHC1
[Isoform p66Shc]: Mitochondrion 1 SHC1
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Syncytin-1]: Virion 1 ERVW-1


文献列表

  • Jiin Felgner, Elizabeth Clarke, Jenny E Hernandez-Davies, Sharon Jan, Ariel S Wirchnianski, Aarti Jain, Rie Nakajima, Algimantas Jasinskas, Erwin Strahsburger, Kartik Chandran, Steven Bradfute, D Huw Davies. Broad antibody and T cell responses to Ebola, Sudan, and Bundibugyo ebolaviruses using mono- and multi-valent adjuvanted glycoprotein vaccines. Antiviral research. 2024 May; 225(?):105851. doi: 10.1016/j.antiviral.2024.105851. [PMID: 38458540]
  • Man Xu, Nan Yang, Jiang Pan, Qiang Hua, Chun-Xiu Li, Jian-He Xu. Remodeling the Homologous Recombination Mechanism of Yarrowia lipolytica for High-Level Biosynthesis of Squalene. Journal of agricultural and food chemistry. 2024 May; 72(17):9984-9993. doi: 10.1021/acs.jafc.4c01779. [PMID: 38635942]
  • Xiao-Bo Li, Chun-Li Huang, Ying Zhang, Jing-Yang Ding, Gui-Sheng Xiang, Guang-Hui Zhang, Sheng-Chao Yang, Bing Hao. Promiscuous Oxidosqualene Cyclases from Neoalsomitra integrifoliola Catalyzing the Formation of Tetracyclic, Pentacyclic, and Heterocyclic Triterpenes. Organic letters. 2024 Apr; 26(15):3119-3123. doi: 10.1021/acs.orglett.4c00730. [PMID: 38588021]
  • Lilit Grigoryan, Yupeng Feng, Lorenza Bellusci, Lilin Lai, Bushra Wali, Madison Ellis, Meng Yuan, Prabhu S Arunachalam, Mengyun Hu, Sangeeta Kowli, Sheena Gupta, Sofia Maysel-Auslender, Holden T Maecker, Hady Samaha, Nadine Rouphael, Ian A Wilson, Alberto C Moreno, Mehul S Suthar, Surender Khurana, Stéphane Pillet, Nathalie Charland, Brian J Ward, Bali Pulendran. AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans. Science immunology. 2024 Apr; 9(94):eadi8039. doi: 10.1126/sciimmunol.adi8039. [PMID: 38579013]
  • Jamila Gagour, Otmane Hallouch, Abderrahim Asbbane, Laila Bijla, Abdellatif Laknifli, Learn-Han Lee, Gokhan Zengin, Abdelhakim Bouyahya, El Hassan Sakar, Said Gharby. A Review of Recent Progresses on Olive Oil Chemical Profiling, Extraction Technology, Shelf-life, and Quality Control. Chemistry & biodiversity. 2024 Apr; 21(4):e202301697. doi: 10.1002/cbdv.202301697. [PMID: 38345352]
  • Yue Zhang, Zuchen Song, Zhimin Zhang, Tao Zhang, Pengfei Gu, Zian Feng, Shuwen Xu, Yang Yang, Deyun Wang, Zhenguang Liu. Preparation and characterization of pickering emulsion stabilized by lovastatin nanoparticles for vaccine adjuvants. International journal of pharmaceutics. 2024 Mar; 653(?):123901. doi: 10.1016/j.ijpharm.2024.123901. [PMID: 38368969]
  • Bhawana Mishra, Shilpi Bansal, Sandhya Tripathi, Smrati Mishra, Ritesh K Yadav, Neelam S Sangwan. Differential regulation of key triterpene synthase gene under abiotic stress in Withania somnifera L. Dunal and its co-relation to sterols and withanolides. Plant physiology and biochemistry : PPB. 2024 Mar; 208(?):108419. doi: 10.1016/j.plaphy.2024.108419. [PMID: 38377888]
  • Yang Ning, Mengsu Liu, Ziyun Ru, Weizhu Zeng, Song Liu, Jingwen Zhou. Efficient synthesis of squalene by cytoplasmic-peroxisomal engineering and regulating lipid metabolism in Yarrowia lipolytica. Bioresource technology. 2024 Mar; 395(?):130379. doi: 10.1016/j.biortech.2024.130379. [PMID: 38281547]
  • Chikara Kato, Ibuki Kusumoto, Shunji Kato, Yurika Otoki, Junya Ito, Hirono Totsuka, Arun Rajgopal, Jina Hong, Kiyotaka Nakagawa. Induction of ferroptosis in human keratinocyte HaCaT cells by squalene hydroperoxide: Possible prevention of skin ferroptosis by botanical extracts. Biochemical and biophysical research communications. 2024 Feb; 698(?):149553. doi: 10.1016/j.bbrc.2024.149553. [PMID: 38271833]
  • Sung Chul Park, Breanne N Steffan, Fang Yun Lim, Raveena Gupta, Fatma Ayaloglu Butun, Hongyu Chen, Rosa Ye, Timothy Decker, Chengcang C Wu, Neil L Kelleher, Jin Woo Bok, Nancy P Keller. Terpenoid balance in Aspergillus nidulans unveiled by heterologous squalene synthase expression. Science advances. 2024 Feb; 10(8):eadk7416. doi: 10.1126/sciadv.adk7416. [PMID: 38381828]
  • Yongshuo Ma, Yi Shang, Gregory Stephanopoulos. Engineering peroxisomal biosynthetic pathways for maximization of triterpene production in Yarrowia lipolytica. Proceedings of the National Academy of Sciences of the United States of America. 2024 Jan; 121(5):e2314798121. doi: 10.1073/pnas.2314798121. [PMID: 38261612]
  • Shuang-Yan Zhang, Yu-Qing Peng, Gui-Sheng Xiang, Wan-Ling Song, Lei Feng, Xin-Yue Jiang, Xue-Jiao Li, Si-Mei He, Sheng-Chao Yang, Yan Zhao, Guang-Hui Zhang. Functional characterization of genes related to triterpene and flavonoid biosynthesis in Cyclocarya paliurus. Planta. 2024 Jan; 259(2):50. doi: 10.1007/s00425-023-04282-1. [PMID: 38285114]
  • Xiao-Liu Liu, Jing Xie, Zhen-Ni Xie, Can Zhong, Hao Liu, Shui-Han Zhang, Jian Jin. Identification of squalene epoxidase in triterpenes biosynthesis in Poria cocos by molecular docking and CRISPR-Cas9 gene editing. Microbial cell factories. 2024 Jan; 23(1):34. doi: 10.1186/s12934-024-02306-3. [PMID: 38273342]
  • Paweł Paśko, Agnieszka Galanty, Emilia Ramos-Zambrano, Alma Leticia Martinez Ayala, Efren Delgado, Joanna Gdula- Argasińska, Paweł Zagrodzki, Robert Podsiadły, Joseph Deutsch, Shela Gorinstein. Pseudocereal Oils, Authenticated by Fourier Transform Infrared Spectroscopy, and their Chemopreventive Properties. Plant foods for human nutrition (Dordrecht, Netherlands). 2024 Jan; ?(?):. doi: 10.1007/s11130-024-01139-0. [PMID: 38231454]
  • Jing-Jing Zhang, Yan Gao, Xiao Xu, Mei-Ling Zhao, Bo-Nan Xi, Yu Shu, Cong Li, Yehua Shen. In Situ Rapid Analysis of Squalene, Tocopherols, and Sterols in Walnut Oils Based on Supercritical Fluid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry. Journal of agricultural and food chemistry. 2023 Nov; 71(43):16371-16380. doi: 10.1021/acs.jafc.3c05857. [PMID: 37867462]
  • Javier Sánchez-Marco, Seyed Hesamoddin Bidooki, Roubi Abuobeid, Cristina Barranquero, Tania Herrero-Continente, Carmen Arnal, Roberto Martínez-Beamonte, Roberto Lasheras, Joaquín C Surra, María A Navarro, María J Rodríguez-Yoldi, Manuel Arruebo, Victor Sebastian, Jesús Osada. Thioredoxin domain containing 5 is involved in the hepatic storage of squalene into lipid droplets in a sex-specific way. The Journal of nutritional biochemistry. 2023 Oct; ?(?):109503. doi: 10.1016/j.jnutbio.2023.109503. [PMID: 37898391]
  • M Luisa Hernández, Cristina Muñoz-Ocaña, Pilar Posada, M Dolores Sicardo, Dámaso Hornero-Méndez, Raquel B Gómez-Coca, Angjelina Belaj, Wenceslao Moreda, José M Martínez-Rivas. Functional Characterization of Four Olive Squalene Synthases with Respect to the Squalene Content of the Virgin Olive Oil. Journal of agricultural and food chemistry. 2023 Oct; 71(42):15701-15712. doi: 10.1021/acs.jafc.3c05322. [PMID: 37815987]
  • Maria Breygina, Dmitry Kochkin, Alexander Voronkov, Tatiana Ivanova, Ksenia Babushkina, Ekaterina Klimenko. Plant Hormone and Fatty Acid Screening of Nicotiana tabacum and Lilium longiflorum Stigma Exudates. Biomolecules. 2023 08; 13(9):. doi: 10.3390/biom13091313. [PMID: 37759713]
  • Josephine G LoRicco, Ingo Hoffmann, Antonino Caliò, Judith Peters. The membrane regulator squalane increases membrane rigidity under high hydrostatic pressure in archaeal membrane mimics. Soft matter. 2023 Aug; 19(33):6280-6286. doi: 10.1039/d3sm00352c. [PMID: 37553974]
  • Jinling Li, Shuai Wang, Yinan Miao, Ya Wan, Chun Li, Ying Wang. Mining and modification of Oryza sativa-derived squalene epoxidase for improved β-amyrin production in Saccharomyces cerevisiae. Journal of biotechnology. 2023 Aug; 375(?):1-11. doi: 10.1016/j.jbiotec.2023.08.004. [PMID: 37597655]
  • Roubi Abuobeid, Luis V Herrera-Marcos, Carmen Arnal, Seyed Hesamoddin Bidooki, Javier Sánchez-Marco, Roberto Lasheras, Joaquín C Surra, María Jesús Rodríguez-Yoldi, Roberto Martínez-Beamonte, Jesús Osada. Differentially Expressed Genes in Response to a Squalene-Supplemented Diet Are Accurate Discriminants of Porcine Non-Alcoholic Steatohepatitis. International journal of molecular sciences. 2023 Aug; 24(16):. doi: 10.3390/ijms241612552. [PMID: 37628732]
  • Carl Recsei, Robert A Russell, Marina Cagnes, Tamim Darwish. Deuterated squalene and sterols from modified Saccharomyces cerevisiae. Organic & biomolecular chemistry. 2023 Jul; ?(?):. doi: 10.1039/d3ob00754e. [PMID: 37523212]
  • Ana Guadalupe Fracchia-Durán, Emilia Ramos-Zambrano, Facundo Joaquín Márquez-Rocha, Alma Leticia Martínez-Ayala. Bioprocess conditions and regulation factors to optimize squalene production in thraustochytrids. World journal of microbiology & biotechnology. 2023 Jul; 39(9):251. doi: 10.1007/s11274-023-03689-y. [PMID: 37442840]
  • Fan Zhang, Yunpeng Wang, Jingyang Yue, Rongrong Zhang, Yong-Er Hu, Ruoshi Huang, Ai-Jia Ji, B Andes Hess, Zhongqiu Liu, Lixin Duan, Ruibo Wu. Discovering a uniform functional trade-off of the CBC-type 2,3-oxidosqualene cyclases and deciphering its chemical logic. Science advances. 2023 06; 9(23):eadh1418. doi: 10.1126/sciadv.adh1418. [PMID: 37285431]
  • Anna Grygier, Suryakant Chakradhari, Katarzyna Ratusz, Magdalena Rudzińska, Khageshwar Singh Patel, Danija Lazdiņa, Dalija Segliņa, Paweł Górnaś. Evaluation of Selected Medicinal, Timber and Ornamental Legume Species' Seed Oils as Sources of Bioactive Lipophilic Compounds. Molecules (Basel, Switzerland). 2023 May; 28(10):. doi: 10.3390/molecules28103994. [PMID: 37241735]
  • Tri Widyawati, Rony Abdi Syahputra, Siti Syarifah, Imam Bagus Sumantri. Analysis of Antidiabetic Activity of Squalene via In Silico and In Vivo Assay. Molecules (Basel, Switzerland). 2023 Apr; 28(9):. doi: 10.3390/molecules28093783. [PMID: 37175192]
  • Ana Belen Moraleda Merlo, Claude Roux, Andy Bécue, Céline Weyermann. A comparison of the natural and groomed fingermark lipid composition of different donors using GC/MS. Forensic science international. 2023 Apr; ?(?):111709. doi: 10.1016/j.forsciint.2023.111709. [PMID: 37149490]
  • Yunliang Zhang, Weigao Wang, Wenqian Wei, Lu Xia, Song Gao, Weizhu Zeng, Song Liu, Jingwen Zhou. Regulation of Ethanol Assimilation for Efficient Accumulation of Squalene in Saccharomyces cerevisiae. Journal of agricultural and food chemistry. 2023 Apr; 71(16):6389-6397. doi: 10.1021/acs.jafc.3c00515. [PMID: 37052370]
  • Yangmiao Jiao, Xu Li, Xueshuang Huang, Fan Liu, Zaiqi Zhang, Liang Cao. The Identification of SQS/SQE/OSC Gene Families in Regulating the Biosynthesis of Triterpenes in Potentilla anserina. Molecules (Basel, Switzerland). 2023 Mar; 28(6):. doi: 10.3390/molecules28062782. [PMID: 36985754]
  • Shuai Wang, Yumei Feng, Yin Lou, Jingping Niu, Congcong Yin, Jinzhong Zhao, Weijun Du, Aiqin Yue. 3-Hydroxy-3-methylglutaryl coenzyme A reductase genes from Glycine max regulate plant growth and isoprenoid biosynthesis. Scientific reports. 2023 03; 13(1):3902. doi: 10.1038/s41598-023-30797-4. [PMID: 36890158]
  • Hidayat Hussain, Jianbo Xiao, Akbar Ali, Ivan R Green, Bernhard Westermann. Unusually cyclized triterpenoids: occurrence, biosynthesis and chemical synthesis. Natural product reports. 2023 Feb; 40(2):412-451. doi: 10.1039/d2np00033d. [PMID: 36458822]
  • Thomas R Henson, Katherine A Richards, Siva K Gandhapudi, Jerold G Woodward, Andrea J Sant. R-DOTAP Cationic Lipid Nanoparticles Outperform Squalene-Based Adjuvant Systems in Elicitation of CD4 T Cells after Recombinant Influenza Hemagglutinin Vaccination. Viruses. 2023 Feb; 15(2):. doi: 10.3390/v15020538. [PMID: 36851752]
  • Frédéric Lirussi, Kyrylo Pyrshev, Semen Yesylevskyy, Timothée Rivel, Tatiana Lopez, Eleonore Coppens, Simona Mura, Patrick Couvreur, Christophe Ramseyer. Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells. Biochimica et biophysica acta. Molecular basis of disease. 2023 02; 1869(2):166614. doi: 10.1016/j.bbadis.2022.166614. [PMID: 36494037]
  • Luis V Herrera-Marcos, Roberto Martínez-Beamonte, Carmen Arnal, Cristina Barranquero, Juan J Puente-Lanzarote, Tania Herrero-Continente, José M Lou-Bonafonte, Gonzalo Gonzalo-Romeo, Gabriele Mocciaro, Benjamin Jenkins, Joaquín C Surra, María J Rodríguez-Yoldi, Juan Carlos Burillo, Roberto Lasheras, Agustín García-Gil, Antonio Güemes, Albert Koulman, Jesús Osada. Dietary squalene supplementation decreases triglyceride species and modifies phospholipid lipidomic profile in the liver of a porcine model of non-alcoholic steatohepatitis. The Journal of nutritional biochemistry. 2023 02; 112(?):109207. doi: 10.1016/j.jnutbio.2022.109207. [PMID: 36402249]
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