alpha-Curcumene (BioDeep_00000019563)

 

Secondary id: BioDeep_00000007518, BioDeep_00001869601

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


1-methyl-4-(6-methylhept-5-en-2-yl)benzene

化学式: C15H22 (202.1721)
中文名称: Alpha-姜黄烯, α-姜黄素
谱图信息: 最多检出来源 Homo sapiens(plant) 15.05%

分子结构信息

SMILES: CC(C)=CCCC(C)c1ccc(C)cc1
InChI: InChI=1S/C15H22/c1-12(2)6-5-7-14(4)15-10-8-13(3)9-11-15/h6,8-11,14H,5,7H2,1-4H3

描述信息

alpha-Curcumene belongs to the family of Sesquiterpenes. These are terpenes with three consecutive isoprene units

同义名列表

15 个代谢物同义名

1-methyl-4-(6-methylhept-5-en-2-yl)benzene; 1-(1,5-Dimethyl-4-hexenyl)-4-methylbenzene; (R)-Isomer OF alpha-curcumene; (S)-Isomer OF alpha-curcumene; 2-Methyl-6-p-tolyl-2-heptene; (-)-alpha-Curcumene; Aromatic curcumene; alpha-Curcumene; Aryl-curcumene; AR-Curcumene; Α-curcumene; a-Curcumene; Curcumene; alpha-Curcumene; alpha-Curcumene



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

15 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(14)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

533 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ARG1, CASP3, CCND1, EGFR, ELANE, ERBB2, ESR1, HPGDS, MAPK3, PIK3CA, PTGS2, TFPT, TNK1, VEGFA
Peripheral membrane protein 4 ACHE, ESR1, PTGS2, TNK1
Endosome membrane 2 EGFR, ERBB2
Endoplasmic reticulum membrane 2 EGFR, PTGS2
Nucleus 10 ACHE, ARG1, CASP3, CCND1, EGFR, ERBB2, ESR1, MAPK3, TFPT, VEGFA
cytosol 10 ARG1, CASP3, CCND1, ELANE, ERBB2, ESR1, GSR, HPGDS, MAPK3, PIK3CA
phagocytic vesicle 1 ELANE
centrosome 1 CCND1
nucleoplasm 7 CASP3, CCND1, ERBB2, ESR1, HPGDS, MAPK3, TFPT
Cell membrane 5 ACHE, EGFR, ERBB2, ESR1, TNF
Cytoplasmic side 1 ESR1
lamellipodium 1 PIK3CA
ruffle membrane 2 EGFR, ERBB2
Cytoplasmic granule 1 ARG1
Early endosome membrane 1 EGFR
Synapse 1 ACHE
cell junction 1 EGFR
cell surface 5 ACHE, EGFR, ELANE, TNF, VEGFA
glutamatergic synapse 3 CASP3, EGFR, MAPK3
Golgi apparatus 4 ACHE, ESR1, MAPK3, VEGFA
Golgi membrane 1 EGFR
neuromuscular junction 2 ACHE, ERBB2
neuronal cell body 2 CASP3, TNF
presynaptic membrane 1 ERBB2
endosome 1 EGFR
plasma membrane 8 ACHE, EGFR, ERBB2, ESR1, MAPK3, PIK3CA, TNF, TNK1
Membrane 6 ACHE, EGFR, ERBB2, ESR1, TNK1, VEGFA
apical plasma membrane 2 EGFR, ERBB2
basolateral plasma membrane 2 EGFR, ERBB2
caveola 2 MAPK3, PTGS2
extracellular exosome 2 ELANE, GSR
endoplasmic reticulum 2 PTGS2, VEGFA
extracellular space 7 ACHE, ARG1, CXCL8, EGFR, ELANE, TNF, VEGFA
perinuclear region of cytoplasm 4 ACHE, EGFR, ERBB2, PIK3CA
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 2 GSR, MAPK3
protein-containing complex 3 EGFR, ESR1, PTGS2
intracellular membrane-bounded organelle 1 HPGDS
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 EGFR, ERBB2
Secreted 3 ACHE, CXCL8, VEGFA
extracellular region 7 ACHE, ARG1, CXCL8, ELANE, ERBB2, TNF, VEGFA
mitochondrial matrix 1 GSR
Extracellular side 1 ACHE
transcription regulator complex 1 ESR1
Nucleus membrane 1 CCND1
nuclear membrane 2 CCND1, EGFR
external side of plasma membrane 2 GSR, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
cytoplasmic vesicle 1 ERBB2
Early endosome 2 ERBB2, MAPK3
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
Membrane raft 2 EGFR, TNF
Cell junction, focal adhesion 1 MAPK3
focal adhesion 2 EGFR, MAPK3
extracellular matrix 1 VEGFA
basement membrane 1 ACHE
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 1 ELANE
secretory granule 2 ELANE, VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 MAPK3
receptor complex 2 EGFR, ERBB2
neuron projection 1 PTGS2
chromatin 1 ESR1
phagocytic cup 1 TNF
cytoskeleton 1 MAPK3
actin filament 1 TFPT
Lipid-anchor, GPI-anchor 1 ACHE
nuclear envelope 1 MAPK3
Membrane, caveola 1 MAPK3
euchromatin 1 ESR1
side of membrane 1 ACHE
myelin sheath 1 ERBB2
pseudopodium 1 MAPK3
basal plasma membrane 2 EGFR, ERBB2
synaptic membrane 1 EGFR
endoplasmic reticulum lumen 2 MAPK3, PTGS2
transcription repressor complex 2 CCND1, ELANE
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 2 ARG1, ELANE
azurophil granule lumen 2 ARG1, ELANE
semaphorin receptor complex 1 ERBB2
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 ESR1
synaptic cleft 1 ACHE
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 ERBB2
Cytoplasmic vesicle, phagosome 1 ELANE
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
Ino80 complex 1 TFPT
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
ERBB3:ERBB2 complex 1 ERBB2
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Xin Wang, Yi Shen, Kiran Thakur, Jinzhi Han, Jian-Guo Zhang, Fei Hu, Zhao-Jun Wei. Antibacterial Activity and Mechanism of Ginger Essential Oil against Escherichia coli and Staphylococcus aureus. Molecules (Basel, Switzerland). 2020 Aug; 25(17):. doi: 10.3390/molecules25173955. [PMID: 32872604]
  • Lidia Czernicka, Agnieszka Ludwiczuk, Edward Rój, Zbigniew Marzec, Agata Jarzab, Wirginia Kukula-Koch. Acetylcholinesterase Inhibitors among Zingiber officinale Terpenes-Extraction Conditions and Thin Layer Chromatography-Based Bioautography Studies. Molecules (Basel, Switzerland). 2020 Apr; 25(7):. doi: 10.3390/molecules25071643. [PMID: 32260053]
  • Lorena C Pena, Gustavo H Jungklaus, Daiani C Savi, Lisandra Ferreira-Maba, André Servienski, Beatriz H L N S Maia, Vinicius Annies, Lygia V Galli-Terasawa, Chirlei Glienke, Vanessa Kava. Muscodor brasiliensis sp. nov. produces volatile organic compounds with activity against Penicillium digitatum. Microbiological research. 2019 Apr; 221(?):28-35. doi: 10.1016/j.micres.2019.01.002. [PMID: 30825939]
  • Mashael Marzouq AlShebly, Fatma Saeed AlQahtani, Marimuthu Govindarajan, Kasi Gopinath, Periasamy Vijayan, Giovanni Benelli. Toxicity of ar-curcumene and epi-β-bisabolol from Hedychium larsenii (Zingiberaceae) essential oil on malaria, chikungunya and St. Louis encephalitis mosquito vectors. Ecotoxicology and environmental safety. 2017 Mar; 137(?):149-157. doi: 10.1016/j.ecoenv.2016.11.028. [PMID: 27918946]
  • Djamila Merghache, Zahia Boucherit-Otmani, Salima Merghache, Ilyas Chikhi, Chaouki Selles, Kebir Boucherit. Chemical composition, antibacterial, antifungal and antioxidant activities of Algerian Eryngium tricuspidatum L. essential oil. Natural product research. 2014; 28(11):795-807. doi: 10.1080/14786419.2014.883392. [PMID: 24559136]
  • Challa Ravi Kiran, Ashok Kumar Chakka, K P Padmakumari Amma, A Nirmala Menon, M M Sree Kumar, V V Venugopalan. Influence of cultivar and maturity at harvest on the essential oil composition, oleoresin and [6]-gingerol contents in fresh ginger from northeast India. Journal of agricultural and food chemistry. 2013 May; 61(17):4145-54. doi: 10.1021/jf400095y. [PMID: 23570262]
  • Julia A Podlogar, Eugen J Verspohl. Antiinflammatory effects of ginger and some of its components in human bronchial epithelial (BEAS-2B) cells. Phytotherapy research : PTR. 2012 Mar; 26(3):333-6. doi: 10.1002/ptr.3558. [PMID: 21698672]
  • Cong Zhang, Min-Jian Qin, Pan Shu, Jun-Li Hong, Lin Lü, Dan-Xia He. Chemical variations of the essential oils in flower heads of Chrysanthemum indicum L. from China. Chemistry & biodiversity. 2010 Dec; 7(12):2951-62. doi: 10.1002/cbdv.201000034. [PMID: 21162008]
  • Chao Zhao, Hua-guo Chen, Li Cheng, Xin Zhou, Zai-bo Yang, Yi-sha Zhang. [Analysis of volatile oil in herb of pimpinella candolleana by SPME-GC-MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Sep; 32(17):1759-62. doi: . [PMID: 17992994]
  • Naoki Sugimoto, Atsuko Tada, Takashi Yamazaki, Kenichi Tanamoto. [Antimicrobial activity and constituents in rumput roman extract as a natural food preservative]. Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan. 2007 Aug; 48(4):106-11. doi: 10.3358/shokueishi.48.106. [PMID: 17892004]
  • N Y Qin, F Q Yang, Y T Wang, S P Li. Quantitative determination of eight components in rhizome (Jianghuang) and tuberous root (Yujin) of Curcuma longa using pressurized liquid extraction and gas chromatography-mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2007 Jan; 43(2):486-92. doi: 10.1016/j.jpba.2006.07.034. [PMID: 16930909]
  • George F Antonious, Tejinder S Kochhar. Zingiberene and curcumene in wild tomato. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2003 Jul; 38(4):489-500. doi: 10.1081/pfc-120021668. [PMID: 12856930]
  • A C Reddy, B R Lokesh. Effect of dietary turmeric (Curcuma longa) on iron-induced lipid peroxidation in the rat liver. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1994 Mar; 32(3):279-83. doi: 10.1016/0278-6915(94)90201-1. [PMID: 8157223]