Skimmianine (BioDeep_00000017345)
Secondary id: BioDeep_00000003592
human metabolite PANOMIX_OTCML-2023 blood metabolite
代谢物信息卡片
InChI=1/C14H13NO4/c1-16-10-5-4-8-11(13(10)18-3)15-14-9(6-7-19-14)12(8)17-2/h4-7H,1-3H
化学式: C14H13NO4 (259.0844538)
中文名称: 茵芋碱
谱图信息:
最多检出来源 Macaca mulatta(otcml) 3.21%
分子结构信息
SMILES: COC1=C(C2=C(C=C1)C(=C3C=COC3=N2)OC)OC
InChI: InChI=1S/C14H13NO4/c1-16-10-5-4-8-11(13(10)18-3)15-14-9(6-7-19-14)12(8)17-2/h4-7H,1-3H3
描述信息
Skimmianine is an organonitrogen heterocyclic compound, an organic heterotricyclic compound, an oxacycle and an alkaloid antibiotic.
Skimmianine is a natural product found in Haplophyllum bucharicum, Haplophyllum cappadocicum, and other organisms with data available.
Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity[1].
Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity[1].
同义名列表
30 个代谢物同义名
InChI=1/C14H13NO4/c1-16-10-5-4-8-11(13(10)18-3)15-14-9(6-7-19-14)12(8)17-2/h4-7H,1-3H; FURO(2,3-b)QUINOLINE, 4,7,8-TRIMETHOXY-; Furo[2,3-b]quinoline, 4,7,8-trimethoxy-; 4,7,8-trimethoxyfurano[2,3-b]quinoline; Furo[2,3-b]quinoline,4,7,8-trimethoxy-; 4,7,8-Trimethoxyfuro[2,3-b]quinoline #; 4,7,8-trimethoxy-furo(2,3-b)quinoline; 4,7,8-Trimethoxyfuro[2,3-b]quinoline; SLSIBLKBHNKZTB-UHFFFAOYSA-N; Skimmianine (beta-Fagarine); Furo[2, 4,7,8-trimethoxy-; Prestwick2_000668; Prestwick0_000668; Prestwick1_000668; Prestwick3_000668; SKIMMIANINE [MI]; .beta.-Fagarine; UNII-4E1KLC380B; Chloroxylonine; beta-Fagarine; Oprea1_449938; MEGxp0_000036; BPBio1_000809; Oprea1_598261; Skimmiamine; CAS-83-95-4; Skimmianine; b-fagarine; 4E1KLC380B; Skimmianin
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:9172
- KEGG: C10740
- PubChem: 6760
- HMDB: HMDB0258333
- ChEMBL: CHEMBL21396
- Wikipedia: Skimmianine
- MeSH: skimmianine
- ChemIDplus: 0000083954
- KNApSAcK: C00002198
- CAS: 5255-76-5
- CAS: 83-95-4
- medchemexpress: HY-N2081
- MetaboLights: MTBLC9172
- PubChem: 12923
- 3DMET: B04106
- NIKKAJI: J4.887I
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
226 个相关的物种来源信息
- 1006069 Haplophyllum bucharicum:
- 2839963 Zanthoxylum asiaticum:
- 354522 Tetradium glabrifolium: 10.1016/0031-9422(95)00248-6
- 2099548 Zanthoxylum zanthoxyloides:
- 354527 Zanthoxylum avicennae:
- 1056465 Zanthoxylum beecheyanum: 10.1002/JCCS.200400159
- 354507 Orixa japonica:
- 159045 Glycosmis mauritiana:
- 2714546 Zanthoxylum tragodes: 10.2307/4117899
- 1006079 Haplophyllum ramosissimum:
- 1312821 Melicope xanthoxyloides: 10.2307/4117899
- 67931 Flindersia laevicarpa:
- 2099547 Zanthoxylum viride: 10.2307/4117899
- 1006075 Haplophyllum griffithianum:
- 298346 Dictamnus albus:
- 1081050 Geijera salicifolia:
- 1291627 Zanthoxylum gilletii:
- 76967 Glycosmis pentaphylla:
- 1006078 Haplophyllum popovii: 10.2307/4117899
- 1671342 Zanthoxylum chalybeum:
- 354530 Zanthoxylum schinifolium:
- 992815 Zanthoxylum leprieurii:
- 1793828 Leionema nudum:
- 77003 Phebalium: 10.2307/4117899
- 549412 Balfourodendron riedelianum: 10.2307/4117899
- 452782 Haplophyllum robustum: 10.2307/4117899
- 37565 Ruta graveolens:
- 282608 Drummondita hassellii: 10.1016/0031-9422(92)80274-I
- 549434 Zanthoxylum rhoifolium:
- 67932 Flindersia maculosa: 10.1071/CH9570480
- 328402 Zanthoxylum simulans:
- 159071 Zanthoxylum ailanthoides:
- 1006070 Haplophyllum cappadocicum: 10.1016/0031-9422(92)83302-F
- 452777 Haplophyllum latifolium:
- 452768 Haplophyllum acutifolium:
- 452784 Haplophyllum tuberculatum:
- 2896588 Spiranthera odoratissima:
- 452779 Haplophyllum obtusifolium:
- 2820928 Ertela trifolia:
- 354517 Skimmia reevesiana: 10.1016/S0031-9422(00)84814-1
- 1224754 Clausena dunniana: 10.1002/HLCA.200390259
- 159034 Clausena anisata: 10.1002/HLCA.200390259
- 76957 Chorilaena quercifolia: 10.1016/0031-9422(96)00355-X
- 681508 Zanthoxylum ekmanii: 10.1016/S0031-9422(00)91132-4
- 549427 Metrodorea nigra: 10.1016/0031-9422(95)00504-Z
- 68527 Aegle marmelos:
- 714465 Dictamnus dasycarpus: 10.1016/S0031-9422(98)00519-6
- 549402 Esenbeckia grandiflora: 10.1016/J.FITOTE.2003.08.004
- 697038 Melicope semecarpifolia:
- 1654694 Esenbeckia febrifuga: 10.1016/J.PHYMED.2008.02.001
- 1317904 Vepris soyauxii:
- 2709026 Vepris suaveolens: 10.1021/NP800276F
- 354528 Zanthoxylum nitidum:
- 2894648 Raputiarana heptaphylla: 10.1248/CPB.59.855
- 67923 Flindersia bennettiana: 10.1071/CH9600427
- 1344466 Esenbeckia leiocarpa: 10.3390/MOLECULES15129205
- 1220089 Vepris nobilis:
- 68552 Nematolepis phebalioides: 10.1021/NP50100A030
- 697043 Zanthoxylum wutaiense: 10.1021/NP700719E
- 452790 Ruta chalepensis:
- 675743 Ruta macrophylla: 10.1007/BF00055511
- 1489662 Glycosmis macrophylla: 10.1016/J.PHYTOL.2011.03.002
- 2839964 Zanthoxylum dimorphophyllum: 10.1002/JCCS.200400099
- 1056472 Zanthoxylum mayu:
- 159048 Glycosmis parviflora: 10.1016/0031-9422(95)00171-3
- 650008 Glycosmis citrifolia: 10.1016/0031-9422(95)00171-3
- 1226053 Boronia ternata: 10.1071/CH9630292
- 549433 Vepris simplicifolia: 10.1016/0031-9422(88)84136-0
- 76972 Sarcomelicope simplicifolia: 10.1016/0031-9422(88)84136-0
- 482953 Teclea simplicifolia: 10.1016/0031-9422(88)84136-0
- 2695420 Vepris trichocarpa: 10.1021/NP0106182
- 1006083 Haplophyllum thesioides:
- 2057143 Myrtopsis macrocarpa: 10.1016/S0031-9422(00)86717-5
- 2321333 Raputia praetermissa: 10.1590/S0103-50532011000700021
- 1279153 Pitavia punctata: 10.1016/S0031-9422(00)97383-7
- 1654682 Almeidea rubra: 10.1590/S0103-50531998000100007
- 452770 Haplophyllum bungei:
- 452773 Haplophyllum dauricum: 10.1007/BF00574794
- 452780 Haplophyllum patavinum: 10.1080/10575630290019985
- 354485 Acronychia pedunculata:
- 549407 Adiscanthus fusciflorus: 10.3390/MOLECULES190812031
- 354503 Melicope triphylla:
- 159052 Glycosmis trichanthera: 10.1016/S0031-9422(97)00986-2
- 416188 Choisya ternata: 10.1039/B707576F
- 2099532 Zanthoxylum coco:
- 68554 Phellodendron amurense: 10.1016/S0031-9422(97)01130-8
- 2896591 Stauranthus perforatus: 10.1055/S-2000-8595
- 452791 Ruta corsica: 10.1016/J.FITOTE.2003.12.014
- 1006077 Haplophyllum myrtifolium: 10.1016/S0367-326X(03)00147-3
- 1226106 Picrella glandulosa:
- 549422 Hortia longifolia: 10.1021/JO00829A053
- 68535 Casimiroa edulis:
- 1475459 Zanthoxylum culantrillo:
- 1136780 Peltostigma guatemalense: 10.1080/14786410802228439
- 2899779 Decatropis bicolor:
- 452797 Thamnosma montana: 10.1016/S0040-4020(01)99086-6
- 430988 Zanthoxylum capense: 10.1016/S0031-9422(00)85715-5
- 1899209 Zanthoxylum delagoense: 10.1016/S0031-9422(00)85715-5
- 1641041 Agathosma bisulca: 10.1016/S0031-9422(00)81426-0
- 430971 Agathosma capensis: 10.1016/S0031-9422(00)81426-0
- 452771 Haplophyllum buxbaumii: 10.1016/S0031-9422(00)83563-3
- 408134 Melicope quadrilocularis: 10.1248/CPB.56.727
- 2042453 Ptelea crenulata: 10.1016/S0031-9422(00)86348-7
- 2492889 Philotheca thryptomenoides: 10.1016/0305-1978(94)90095-7
- 1336656 Zanthoxylum scandens: 10.1055/S-2006-961713
- 354523 Tetradium ruticarpum: 10.1002/CBDV.200900289
- 1226072 Drummondita calida: 10.1055/S-0030-1270963
- 210365 Skimmia japonica:
- 378919 Agathosma: 10.1016/0031-9422(90)85447-N
- 1006069 Haplophyllum bucharicum:
- 2839963 Zanthoxylum asiaticum:
- 354522 Tetradium glabrifolium: 10.1016/0031-9422(95)00248-6
- 2099548 Zanthoxylum zanthoxyloides:
- 354527 Zanthoxylum avicennae:
- 1056465 Zanthoxylum beecheyanum: 10.1002/JCCS.200400159
- 354507 Orixa japonica:
- 159045 Glycosmis mauritiana:
- 2714546 Zanthoxylum tragodes: 10.2307/4117899
- 1006079 Haplophyllum ramosissimum:
- 1312821 Melicope xanthoxyloides: 10.2307/4117899
- 67931 Flindersia laevicarpa:
- 2099547 Zanthoxylum viride: 10.2307/4117899
- 1006075 Haplophyllum griffithianum:
- 298346 Dictamnus albus:
- 1081050 Geijera salicifolia:
- 1291627 Zanthoxylum gilletii:
- 76967 Glycosmis pentaphylla:
- 1006078 Haplophyllum popovii: 10.2307/4117899
- 1671342 Zanthoxylum chalybeum:
- 354530 Zanthoxylum schinifolium:
- 992815 Zanthoxylum leprieurii:
- 1793828 Leionema nudum:
- 77003 Phebalium: 10.2307/4117899
- 549412 Balfourodendron riedelianum: 10.2307/4117899
- 452782 Haplophyllum robustum: 10.2307/4117899
- 37565 Ruta graveolens:
- 282608 Drummondita hassellii: 10.1016/0031-9422(92)80274-I
- 549434 Zanthoxylum rhoifolium:
- 67932 Flindersia maculosa: 10.1071/CH9570480
- 328402 Zanthoxylum simulans:
- 159071 Zanthoxylum ailanthoides:
- 1006070 Haplophyllum cappadocicum: 10.1016/0031-9422(92)83302-F
- 452777 Haplophyllum latifolium:
- 452768 Haplophyllum acutifolium:
- 452784 Haplophyllum tuberculatum:
- 2896588 Spiranthera odoratissima:
- 452779 Haplophyllum obtusifolium:
- 2820928 Ertela trifolia:
- 354517 Skimmia reevesiana: 10.1016/S0031-9422(00)84814-1
- 1224754 Clausena dunniana: 10.1002/HLCA.200390259
- 159034 Clausena anisata: 10.1002/HLCA.200390259
- 76957 Chorilaena quercifolia: 10.1016/0031-9422(96)00355-X
- 681508 Zanthoxylum ekmanii: 10.1016/S0031-9422(00)91132-4
- 549427 Metrodorea nigra: 10.1016/0031-9422(95)00504-Z
- 68527 Aegle marmelos:
- 714465 Dictamnus dasycarpus: 10.1016/S0031-9422(98)00519-6
- 549402 Esenbeckia grandiflora: 10.1016/J.FITOTE.2003.08.004
- 697038 Melicope semecarpifolia:
- 1654694 Esenbeckia febrifuga: 10.1016/J.PHYMED.2008.02.001
- 1317904 Vepris soyauxii:
- 2709026 Vepris suaveolens: 10.1021/NP800276F
- 354528 Zanthoxylum nitidum:
- 2894648 Raputiarana heptaphylla: 10.1248/CPB.59.855
- 67923 Flindersia bennettiana: 10.1071/CH9600427
- 1344466 Esenbeckia leiocarpa: 10.3390/MOLECULES15129205
- 1220089 Vepris nobilis:
- 68552 Nematolepis phebalioides: 10.1021/NP50100A030
- 697043 Zanthoxylum wutaiense: 10.1021/NP700719E
- 452790 Ruta chalepensis:
- 675743 Ruta macrophylla: 10.1007/BF00055511
- 1489662 Glycosmis macrophylla: 10.1016/J.PHYTOL.2011.03.002
- 2839964 Zanthoxylum dimorphophyllum: 10.1002/JCCS.200400099
- 1056472 Zanthoxylum mayu:
- 159048 Glycosmis parviflora: 10.1016/0031-9422(95)00171-3
- 650008 Glycosmis citrifolia: 10.1016/0031-9422(95)00171-3
- 1226053 Boronia ternata: 10.1071/CH9630292
- 549433 Vepris simplicifolia: 10.1016/0031-9422(88)84136-0
- 76972 Sarcomelicope simplicifolia: 10.1016/0031-9422(88)84136-0
- 482953 Teclea simplicifolia: 10.1016/0031-9422(88)84136-0
- 2695420 Vepris trichocarpa: 10.1021/NP0106182
- 1006083 Haplophyllum thesioides:
- 2057143 Myrtopsis macrocarpa: 10.1016/S0031-9422(00)86717-5
- 2321333 Raputia praetermissa: 10.1590/S0103-50532011000700021
- 1279153 Pitavia punctata: 10.1016/S0031-9422(00)97383-7
- 1654682 Almeidea rubra: 10.1590/S0103-50531998000100007
- 452770 Haplophyllum bungei:
- 452773 Haplophyllum dauricum: 10.1007/BF00574794
- 452780 Haplophyllum patavinum: 10.1080/10575630290019985
- 354485 Acronychia pedunculata:
- 549407 Adiscanthus fusciflorus: 10.3390/MOLECULES190812031
- 354503 Melicope triphylla:
- 159052 Glycosmis trichanthera: 10.1016/S0031-9422(97)00986-2
- 416188 Choisya ternata: 10.1039/B707576F
- 2099532 Zanthoxylum coco:
- 68554 Phellodendron amurense: 10.1016/S0031-9422(97)01130-8
- 2896591 Stauranthus perforatus: 10.1055/S-2000-8595
- 452791 Ruta corsica: 10.1016/J.FITOTE.2003.12.014
- 1006077 Haplophyllum myrtifolium: 10.1016/S0367-326X(03)00147-3
- 1226106 Picrella glandulosa:
- 549422 Hortia longifolia: 10.1021/JO00829A053
- 68535 Casimiroa edulis:
- 1475459 Zanthoxylum culantrillo:
- 1136780 Peltostigma guatemalense: 10.1080/14786410802228439
- 2899779 Decatropis bicolor:
- 452797 Thamnosma montana: 10.1016/S0040-4020(01)99086-6
- 430988 Zanthoxylum capense: 10.1016/S0031-9422(00)85715-5
- 1899209 Zanthoxylum delagoense: 10.1016/S0031-9422(00)85715-5
- 1641041 Agathosma bisulca: 10.1016/S0031-9422(00)81426-0
- 430971 Agathosma capensis: 10.1016/S0031-9422(00)81426-0
- 452771 Haplophyllum buxbaumii: 10.1016/S0031-9422(00)83563-3
- 408134 Melicope quadrilocularis: 10.1248/CPB.56.727
- 2042453 Ptelea crenulata: 10.1016/S0031-9422(00)86348-7
- 2492889 Philotheca thryptomenoides: 10.1016/0305-1978(94)90095-7
- 1336656 Zanthoxylum scandens: 10.1055/S-2006-961713
- 354523 Tetradium ruticarpum: 10.1002/CBDV.200900289
- 1226072 Drummondita calida: 10.1055/S-0030-1270963
- 210365 Skimmia japonica:
- 378919 Agathosma: 10.1016/0031-9422(90)85447-N
- 9606 Homo sapiens: -
- 354528 Zanthoxylum Nitidum: -
- 714465 Dictamnus dasycarpus Turcz.: -
- 354530 Zanthoxylum schinifolium Sieb. et Zucc.: -
- 328401 Zanthoxylum bungeanum Maxim.: -
- 2901850 Murraya exotica L.: -
- 43711 Murraya paniculata (L.)Jack: -
- 33090 Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Folashade A Ogunrinade, Stephanie T Guetchueng, Folashade O Katola, Mutalib A Aderogba, Idowu S Akande, Satyajit D Sarker, Olumayokun A Olajide. Zanthoxylum zanthoxyloides inhibits lipopolysaccharide- and synthetic hemozoin-induced neuroinflammation in BV-2 microglia: roles of NF-κB transcription factor and NLRP3 inflammasome activation.
The Journal of pharmacy and pharmacology.
2021 Mar; 73(1):118-134. doi:
10.1093/jpp/rgaa019. [PMID: 33791805] - Yixuan Li, Weihua Zhang, Tingting Yin, Ce Wang, Feige Wang, Jing Sun, Lina Liu, Qinghuai Zhang, Chunze Zhang. Inhibition of UDP-glucuronosyltransferases by different furoquinoline alkaloids.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Oct; 50(10):1170-1179. doi:
10.1080/00498254.2020.1760400. [PMID: 32367776] - Natarajan Murugan, Ramalingam Srinivasan, Athiappan Murugan, Myunghee Kim, Devarajan Natarajan. Glycosmis pentaphylla (Rutaceae): A Natural Candidate for the Isolation of Potential Bioactive Arborine and Skimmianine Compounds for Controlling Multidrug-Resistant Staphylococcus aureus.
Frontiers in public health.
2020; 8(?):176. doi:
10.3389/fpubh.2020.00176. [PMID: 32587843] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Blaise Kemajou Nganou, Armelle T Mbaveng, Serge A T Fobofou, Aimé G Fankam, Gabin Thierry M Bitchagno, James D Simo Mpetga, Ludger A Wessjohann, Victor Kuete, Thomas Efferth, Pierre Tane. Furoquinolines and dihydrooxazole alkaloids with cytotoxic activity from the stem bark of Araliopsis soyauxii.
Fitoterapia.
2019 Mar; 133(?):193-199. doi:
10.1016/j.fitote.2019.01.003. [PMID: 30654126] - Aihua Huang, Hui Xu, Ruoting Zhan, Weiwen Chen, Jiawei Liu, Yuguang Chi, Daidi Chen, Xiaoyu Ji, Chaoquan Luo. Metabolic Profile of Skimmianine in Rats Determined by Ultra-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Tandem Mass Spectrometry.
Molecules (Basel, Switzerland).
2017 Mar; 22(4):. doi:
10.3390/molecules22040489. [PMID: 28333075] - Jian-Bo Sun, Wei Qu, Fu-Qin Guan, Lin-Zhen Li, Jing-Yu Liang. A new quinoline alkaloid from the roots of Dictamnus angustifolius.
Chinese journal of natural medicines.
2014 Mar; 12(3):222-4. doi:
10.1016/s1875-5364(14)60037-6. [PMID: 24702810] - Tayyab A Mansoor, Pedro M Borralho, Xuan Luo, Silva Mulhovo, Cecília M P Rodrigues, Maria-José U Ferreira. Apoptosis inducing activity of benzophenanthridine-type alkaloids and 2-arylbenzofuran neolignans in HCT116 colon carcinoma cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2013 Jul; 20(10):923-9. doi:
10.1016/j.phymed.2013.03.026. [PMID: 23643093] - M Ratheesh, G Sindhu, Antony Helen. Anti-inflammatory effect of quinoline alkaloid skimmianine isolated from Ruta graveolens L.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2013 Apr; 62(4):367-76. doi:
10.1007/s00011-013-0588-1. [PMID: 23344232] - Xuan Luo, David Pires, José A Aínsa, Begoña Gracia, Noélia Duarte, Silva Mulhovo, Elsa Anes, Maria-José U Ferreira. Zanthoxylum capense constituents with antimycobacterial activity against Mycobacterium tuberculosis in vitro and ex vivo within human macrophages.
Journal of ethnopharmacology.
2013 Mar; 146(1):417-22. doi:
10.1016/j.jep.2013.01.013. [PMID: 23337743] - Ikarastika Rahayu Abdul Wahab, Nikki Siu Hai Wong, Fabio Boylan. Choisyaternatine, a new alkaloid isolated from Choisya ternata.
Planta medica.
2012 Sep; 78(14):1597-600. doi:
10.1055/s-0032-1315044. [PMID: 22815205] - Yigen Li, Wenjin Huang, Shenyuan Huang, Jiulin Du, Cheng Huang. Screening of anti-cancer agent using zebrafish: comparison with the MTT assay.
Biochemical and biophysical research communications.
2012 May; 422(1):85-90. doi:
10.1016/j.bbrc.2012.04.110. [PMID: 22560901] - Rogerio Alexandre Nunes Dos Santos, João Batista, Suellen Iara Guirra Rosa, Heron Fernandes Torquato, Carmen Lúcia Bassi, Tereza Auxiliadora Nascimento Ribeiro, Paulo Teixeira De Sousa, Angela Márcia Selhorst E Silva Bessera, Cor Jesus Fernandes Fontes, Luiz Everson Da Silva, Márcia Regina Piuvezam. Leishmanicidal effect of Spiranthera odoratíssima (Rutaceae) and its isolated alkaloid skimmianine occurs by a nitric oxide dependent mechanism.
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