Skimmianine (BioDeep_00000003592)

Main id: BioDeep_00000017345

 

human metabolite PANOMIX_OTCML-2023 blood metabolite Cytotoxicity natural product


代谢物信息卡片


4,7,8-trimethoxy-furo(2,3-b)quinoline

化学式: C14H13NO4 (259.0845)
中文名称: 茵芋碱
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: COC1=C(C2=C(C=C1)C(=C3C=COC3=N2)OC)OC
InChI: InChI=1S/C14H13NO4/c1-16-10-5-4-8-11(13(10)18-3)15-14-9(6-7-19-14)12(8)17-2/h4-7H,1-3H3

描述信息

Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity[1].
Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity[1].

同义名列表

4 个代谢物同义名

4,7,8-trimethoxy-furo(2,3-b)quinoline; 4,7,8-Trimethoxyfuro[2,3-b]quinoline; Skimmianine; Skimmianine



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

458 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 AKT1, ALOX5, CAT, CD36, IL18, MAPK3, MYD88, NLRP3, NOS2, PIK3CA, PTGS2, TLR2, TRAF6
Peripheral membrane protein 4 ACHE, ALOX5, GORASP1, PTGS2
Endosome membrane 2 MYD88, TRAF6
Endoplasmic reticulum membrane 1 PTGS2
Nucleus 7 ACHE, AKT1, MAPK3, MYD88, NLRP3, NOS2, TRAF6
cytosol 10 AKT1, ALOX5, CAT, IL18, MAPK3, MYD88, NLRP3, NOS2, PIK3CA, TRAF6
phagocytic vesicle 1 CD36
nucleoplasm 4 AKT1, ALOX5, MAPK3, NOS2
Cell membrane 4 ACHE, AKT1, CD36, TNF
Cytoplasmic side 1 GORASP1
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 1 CD36
Golgi apparatus membrane 2 GORASP1, NLRP3
Synapse 1 ACHE
cell cortex 2 AKT1, TRAF6
cell surface 5 ACHE, CD36, MYD88, TLR2, TNF
glutamatergic synapse 3 AKT1, MAPK3, TRAF6
Golgi apparatus 5 ACHE, CD36, GORASP1, MAPK3, TLR2
Golgi membrane 2 GORASP1, NLRP3
lysosomal membrane 1 GAA
neuromuscular junction 1 ACHE
neuronal cell body 1 TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 4 ALOX5, IL18, NLRP3, NOS2
Lysosome 1 GAA
plasma membrane 12 ACHE, AKT1, BCHE, CD36, GAA, MAPK3, MYD88, NOS2, PIK3CA, TLR2, TNF, TRAF6
Membrane 7 ACHE, AKT1, CAT, CD36, GAA, NLRP3, TLR2
apical plasma membrane 1 CD36
axon 1 CCK
caveola 3 CD36, MAPK3, PTGS2
extracellular exosome 2 CAT, GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 2 NLRP3, PTGS2
extracellular space 8 ACHE, ALOX5, BCHE, CCK, CD36, IL10, IL18, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 5 ACHE, ALOX5, NOS2, PIK3CA, TRAF6
intercalated disc 1 PIK3CA
mitochondrion 3 CAT, MAPK3, NLRP3
protein-containing complex 5 AKT1, CAT, MYD88, PTGS2, TRAF6
intracellular membrane-bounded organelle 2 CAT, GAA
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 1 TLR2
Secreted 7 ACHE, BCHE, CCK, GAA, IL10, IL18, NLRP3
extracellular region 10 ACHE, ALOX5, BCHE, CAT, CCK, GAA, IL10, IL18, NLRP3, TNF
cytoplasmic side of plasma membrane 1 TRAF6
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
CD40 receptor complex 1 TRAF6
external side of plasma membrane 2 CD36, TNF
microtubule cytoskeleton 1 AKT1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 1 MAPK3
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Apical cell membrane 1 CD36
Cytoplasm, perinuclear region 2 ALOX5, NOS2
Membrane raft 3 CD36, TLR2, TNF
Cell junction, focal adhesion 1 MAPK3
focal adhesion 2 CAT, MAPK3
spindle 1 AKT1
cis-Golgi network 1 GORASP1
Peroxisome 2 CAT, NOS2
basement membrane 1 ACHE
collagen trimer 1 CD36
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 MAPK3
receptor complex 2 CD36, TLR2
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
Cytoplasmic vesicle, phagosome membrane 1 TLR2
cell projection 1 TLR2
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 TLR2
cell periphery 1 CD36
cytoskeleton 1 MAPK3
brush border membrane 1 CD36
Cytoplasm, cell cortex 1 TRAF6
blood microparticle 1 BCHE
Lipid-anchor, GPI-anchor 1 ACHE
nuclear envelope 2 ALOX5, MAPK3
Nucleus envelope 1 ALOX5
Endomembrane system 1 NLRP3
Lipid droplet 1 TRAF6
Membrane, caveola 1 MAPK3
microtubule organizing center 1 NLRP3
specific granule membrane 1 CD36
tertiary granule membrane 1 GAA
cell body 1 TLR2
side of membrane 1 ACHE
pseudopodium 1 MAPK3
ficolin-1-rich granule lumen 2 ALOX5, CAT
secretory granule lumen 2 ALOX5, CAT
secretory granule membrane 1 TLR2
endoplasmic reticulum lumen 3 BCHE, MAPK3, PTGS2
nuclear matrix 1 ALOX5
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle membrane 1 CD36
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Nucleus matrix 1 ALOX5
nuclear envelope lumen 2 ALOX5, BCHE
extrinsic component of cytoplasmic side of plasma membrane 2 MYD88, TRAF6
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
Toll-like receptor 1-Toll-like receptor 2 protein complex 1 TLR2
Toll-like receptor 2-Toll-like receptor 6 protein complex 1 TLR2
extrinsic component of plasma membrane 1 MYD88
platelet alpha granule membrane 1 CD36
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
Nucleus intermembrane space 1 ALOX5
autolysosome lumen 1 GAA
[Isoform H]: Cell membrane 1 ACHE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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