L-Threonine (BioDeep_00000000183)

 

Secondary id: BioDeep_00000015002, BioDeep_00000017490, BioDeep_00000229629, BioDeep_00001868009

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


(2S,3R)-2-amino-3-hydroxybutanoic acid

化学式: C4H9NO3 (119.0582404)
中文名称: DL-苏氨酸 (含DL-别苏氨酸), L-苏氨酸, DL-别苏氨酸, DL-苏氨酸, 苏氨酸, l-苏氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.07%

Reviewed

Last reviewed on 2024-07-01.

Cite this Page

L-Threonine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/l-threonine (retrieved 2024-11-22) (BioDeep RN: BioDeep_00000000183). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(C(C(=O)O)N)O
InChI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)

描述信息

L-threonine is an optically active form of threonine having L-configuration. It has a role as a nutraceutical, a micronutrient, a Saccharomyces cerevisiae metabolite, a plant metabolite, an Escherichia coli metabolite, a human metabolite, an algal metabolite and a mouse metabolite. It is an aspartate family amino acid, a proteinogenic amino acid, a threonine and a L-alpha-amino acid. It is a conjugate base of a L-threoninium. It is a conjugate acid of a L-threoninate. It is an enantiomer of a D-threonine. It is a tautomer of a L-threonine zwitterion.
An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.
L-Threonine is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
Threonine is an essential amino acid in humans (provided by food), Threonine is an important residue of many proteins, such as tooth enamel, collagen, and elastin. An important amino acid for the nervous system, threonine also plays an important role in porphyrin and fat metabolism and prevents fat buildup in the liver. Useful with intestinal disorders and indigestion, threonine has also been used to alleviate anxiety and mild depression. (NCI04)
Threonine is an essential amino acid in humans. It is abundant in human plasma, particularly in newborns. Severe deficiency of threonine causes neurological dysfunction and lameness in experimental animals. Threonine is an immunostimulant which promotes the growth of thymus gland. It also can probably promote cell immune defense function. This amino acid has been useful in the treatment of genetic spasticity disorders and multiple sclerosis at a dose of 1 gram daily. It is highly concentrated in meat products, cottage cheese and wheat germ. The threonine content of most of the infant formulas currently on the market is approximately 20\\\\\\% higher than the threonine concentration in human milk. Due to this high threonine content the plasma threonine concentrations are up to twice as high in premature infants fed these formulas than in infants fed human milk. The whey proteins which are used for infant formulas are sweet whey proteins. Sweet whey results from cheese production. Threonine catabolism in mammals appears to be due primarily (70-80\\\\\\%) to the activity of threonine dehydrogenase (EC 1.1.1.103) that oxidizes threonine to 2-amino-3-oxobutyrate, which forms glycine and acetyl CoA, whereas threonine dehydratase (EC 4.2.1.16) that catabolizes threonine into 2-oxobutyrate and ammonia, is significantly less active. Increasing the threonine plasma concentrations leads to accumulation of threonine and glycine in the brain. Such accumulation affects the neurotransmitter balance which may have consequences for the brain development during early postnatal life. Thus, excessive threonine intake during infant feeding should be avoided. (A3450).
An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.
See also: Amlisimod (monomer of) ... View More ...
Threonine (Thr) or L-threonine is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (–NH2) and carboxyl (–COOH) functional groups, along with a side chain (R group) specific to each amino acid. L-threonine is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Threonine is found in all organisms ranging from bacteria to plants to animals. It is classified as a polar, uncharged (at physiological pH), aliphatic amino acid. Threonine is sometimes considered as a branched chain amino acid. Threonine was actually the last of the 20 amino acids to be discovered (in 1938). It was named threonine because it was similar in structure to threonic acid, a four-carbon monosaccharide. Threonine is an essential amino acid in humans, meaning the body cannot synthesize it and that it must be obtained from the diet. Foods high in threonine include cottage cheese, poultry, fish, meat, lentils, black turtle bean and sesame seeds. Adult humans require about 20 mg/kg body weight/day. In plants and microorganisms, threonine is synthesized from aspartic acid via alpha-aspartyl-semialdehyde and homoserine. In proteins, the threonine residue is susceptible to numerous posttranslational modifications. The hydroxyl side-chain can undergo O-linked glycosylation and phosphorylation through the action of a threonine kinase. Threonine is abundant in human plasma, particularly in newborns. Severe deficiency of threonine causes neurological dysfunction and lameness in experimental animals. Threonine is an immunostimulant which promotes the growth of thymus gland. It also can probably promote cell immune defense function. The threonine content of most of the infant formulas currently on the market is approximately 20\\\\\\% higher than the threonine concentration in human milk. Due to this high threonine content the plasma threonine concentrations are up to twice as high in premature infants fed these formulas than in infants fed human milk. The whey proteins which are used for infant formulas are sweet whey proteins. Sweet whey results from cheese production. Increasing the threonine plasma concentrations leads to accumulation of threonine and glycine in the brain. Such accumulation affects the neurotransmitter balance which may have consequences for the brain development during early postnatal life. Thus, excessive threonine intake during infant feeding should be avoided. (PMID 9853925). Threonine is metabolized in at least two ways. In many animals it is converted to pyruvate via threonine dehydrogenase. An intermediate in this pathway can undergo thiolysis with CoA to produce acetyl-CoA and glycine. In humans the gene for threonine dehydrogenase is an inactive pseudogene, so threonine is converted to alpha-ketobutyrate.
From wide variety of protein hydrolysates. Dietary supplement, nutrient

L-Threonine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=72-19-5 (retrieved 2024-07-01) (CAS RN: 72-19-5). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
DL-Threonine, an essential amino acid, has the potential to treat hypostatic leg ulceration[1].
L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed[1].
L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed[1].

同义名列表

111 个代谢物同义名

L-Threonine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 99.0-101.0\\%; L-Threonine, Pharmaceutical Secondary Standard; Certified Reference Material; L-Threonine, United States Pharmacopeia (USP) Reference Standard; L-Threonine, European Pharmacopoeia (EP) Reference Standard; L-Threonine, certified reference material, TraceCERT(R); Butanoic acid, 2-amino-3-hydroxy-, (R-(R*,S*))-; 48: PN: WO2004076659 FIGURE: 7 claimed sequence; LYSINE HYDROCHLORIDE IMPURITY C [EP IMPURITY]; 2-Amino-3-hydroxybutanoic acid, (R-(R*,S*))-; L-Threonine, Vetec(TM) reagent grade, >=98\\%; [R-(R*,S*)]-2-amino-3-hydroxy-Butanoic acid; (2S,3R)-rel-2-Amino-3-hydroxybutanoic acid; (R-(R*,S*))-2-Amino-3-hydroxybutanoic acid; [R-(R*,S*)]-2-Amino-3-hydroxybutanoic acid; L-Threonine, reagent grade, >=98\\% (HPLC); (2S,3R)-rel-2-Amino-3-hydroxybutanoicacid; [R-(R*,S*)]-2-amino-3-hydroxy-Butanoate; (R-(R*,S*))-2-Amino-3-hydroxybutanoate; L-alpha-Amino-beta-hydroxybutyric acid; [R-(R*,S*)]-2-Amino-3-hydroxybutanoate; (2S,3R)-2-amino-3-hydroxybutanoic acid; (2S,3R)-2-Amino-3-hydroxybutyric acid; Threonine, labeled with carbon-14, L-; 3DD2E9AD-DB9A-460E-8A6B-C01B0F67AC4E; L-Threonine, BioXtra, >=99.5\\% (NT); L-alpha-Amino-beta-hydroxybutyrate; (2S,3R)-2-Amino-3-hydroxybutanoate; (2S,3R)-2-Amino-3-hydroxybutyrate; L-Α-amino-β-hydroxybutyric acid; L-a-Amino-b-hydroxybutyric acid; L-Threonine, p.a., 99.0-101.0\\%; L-2-Amino-3-hydroxybutyric acid; 2-amino-3-hydroxybutanoic acid; L-Threonine non-animal source; 2-amino-3-hydroxybutyric acid; L-a-Amino-b-hydroxybutyrate; L-2-Amino-3-hydroxybutyrate; L-Α-amino-β-hydroxybutyrate; 2-Amino-3-hydroxybutanoate; THREONINE (USP MONOGRAPH); 2-Amino-3-hydroxybutyrate; THREONINE [USP MONOGRAPH]; THREONINE (EP MONOGRAPH); THREONINE [EP MONOGRAPH]; Threonine (L-Threonine); L-Threonine (H-Thr-OH); (2S,3R)-(-)-Threonine; L-THREONINE, [U-14C]; L-THREONINE [USP-RS]; Threonine [USAN:INN]; Threonine, L- (8CI); THREONINE [WHO-DD]; L-Threonine (JP17); Treonina [Spanish]; L-(U-14C)Threonine; Threoninum [Latin]; Threoninum (Latin); L-THREONINE [JAN]; THREONINE [VANDF]; L-Threonine (9CI); Allothreonine, D-; THREONINE (MART.); THREONINE [MART.]; L-THREONINE [FCC]; beta-methylserine; THREONINE [HSDB]; THREONINE [INCI]; THREONINE [USAN]; Threonine (VAN); L-(-)-Threonine; L-Threonine,(S); THREONINE [INN]; UNII-TFM6DU5S6A; Threonine (USP); (+/-)-threonine; UNII-2ZD004190S; THREONINE (II); Threonine, DL-; THREONINE [MI]; THREONINE [II]; Tox21_112154_1; (2S)-threonine; THREONINE (L); Threonine, L-; (S)-Threonine; Tox21_112154; L-Threonine;; DL-Threonine; L-Threonine; Threonine #; L Threonine; CAS-72-19-5; 2ZD004190S; TFM6DU5S6A; Threoninum; L-Threonin; AI3-18477; Threonine; Threonin; H-Thr-OH; Treonina; L-Thr-OH; L-thr; H-Thr; thre; thr; T; D-(+)-Threonine; Threonine; L-Threonine; l-Threonine



数据库引用编号

58 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(11)

PlantCyc(0)

代谢反应

48 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(18)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(29)

PharmGKB(0)

414 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nathan M Lewis, Effie C Kisgeropoulos, Carolyn E Lubner, Kathryn R Fixen. Characterization of ferredoxins involved in electron transfer pathways for nitrogen fixation implicates differences in electronic structure in tuning 2[4Fe4S] Fd activity. Journal of inorganic biochemistry. 2024 May; 254(?):112521. doi: 10.1016/j.jinorgbio.2024.112521. [PMID: 38471286]
  • Shota Isogai, Akira Nishimura, Akiko Inoue, Shino Sonohara, Takashi Tsugukuni, Tomoyuki Okada, Hiroshi Takagi. Functional analysis of feedback inhibition-insensitive aspartate kinase identified in a threonine-accumulating mutant of Saccharomyces cerevisiae. Applied and environmental microbiology. 2024 Apr; 90(4):e0015524. doi: 10.1128/aem.00155-24. [PMID: 38456673]
  • Chun Chu, Shengquan Liu, Liangui Nie, Hongming Hu, Yi Liu, Jun Yang. The interactions and biological pathways among metabolomics products of patients with coronary heart disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116305. doi: 10.1016/j.biopha.2024.116305. [PMID: 38422653]
  • Jason L J Lin, Hanna S Yuan. Lipid-Binding Regions within PKC-Related Serine/Threonine Protein Kinase N1 (PKN1) Required for Its Regulation. Biochemistry. 2024 Mar; 63(6):743-753. doi: 10.1021/acs.biochem.4c00009. [PMID: 38441874]
  • Linsong Wang, Chenglei Qin, Qunqun Guo, Yi Han, Guicai Du, Ronggui Li. Transcriptome Study of Bursaphelenchus xylophilus Treated with Fomepizole Reveals a Serine/Threonine-Protein Phosphatase Gene that Is Substantially Linked with Vitality and Pathogenicity. Phytopathology. 2024 Mar; 114(3):630-640. doi: 10.1094/phyto-04-23-0113-r. [PMID: 38457135]
  • Hai Trieu Ly, Khuong Duy Pham, Phung Hien Le, Thi Hong Tuoi Do, Thi Thu Huong Nguyen, Van Minh Le. Pharmacological properties of Ensete glaucum seed extract: Novel insights for antidiabetic effects via modulation of oxidative stress, inflammation, apoptosis and MAPK signaling pathways. Journal of ethnopharmacology. 2024 Feb; 320(?):117427. doi: 10.1016/j.jep.2023.117427. [PMID: 37992883]
  • Yaoliang Sun, Zhiwen Chen, Guobin Liu, Xiaoai Chen, Zihan Shi, Huixu Feng, Lei Yu, Guodong Li, Ke Ding, He Huang, Zhang Zhang, Shilin Xu. Discovery of a potent and selective covalent threonine tyrosine kinase (TTK) inhibitor. Bioorganic chemistry. 2024 Feb; 143(?):107053. doi: 10.1016/j.bioorg.2023.107053. [PMID: 38159497]
  • Mohd Nazam Ansari, Najeeb Ur Rehman, Abdul Samad, Wasim Ahmad. Pharmacological Basis for the Antidiarrheal and Antispasmodic Effects of Cuminaldehyde in Experimental Animals: In Silico, Ex Vivo and In Vivo Studies. Frontiers in bioscience (Landmark edition). 2024 Jan; 29(1):43. doi: 10.31083/j.fbl2901043. [PMID: 38287835]
  • Yuhao Ma, Ganxian Cai, Jianfei Chen, Xue Yang, Guoying Hua, Deping Han, Xinhai Li, Dengzhen Feng, Xuemei Deng. Combined transcriptome and metabolome analysis reveals breed-specific regulatory mechanisms in Dorper and Tan sheep. BMC genomics. 2024 Jan; 25(1):70. doi: 10.1186/s12864-023-09870-9. [PMID: 38233814]
  • Ali A Hajeyah, Majd B Protty, Divyani Paul, Daniela Costa, Nader Omidvar, Bethan Morgan, Yugo Iwasaki, Beth McGill, P Vincent Jenkins, Zaheer Yousef, Keith Allen-Redpath, Shin Soyama, Anirban Choudhury, Rito Mitra, Parveen Yaqoob, James H Morrissey, Peter W Collins, Valerie B O'Donnell. Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease. Journal of lipid research. 2024 Jan; 65(1):100484. doi: 10.1016/j.jlr.2023.100484. [PMID: 38103786]
  • Waqar Ahmed Siddiqui, Muniza Qayyum, Aamina Quddus Qureshi, Momina Khalid, Sehrish Zaffar, Rabiea Bilal. The Bronchodilator Potential of Astragalus sarcocolla: An in vitro Experiment. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2024 Jan; 34(1):58-62. doi: 10.29271/jcpsp.2024.01.58. [PMID: 38185962]
  • Ahad Yamchi, Maryam Rahimi, Bita Javan, Dorsa Abdollahi, Mojgan Salmanian, Majid Shahbazi. Evaluation of the impact of polypeptide-p on diabetic rats upon its cloning, expression, and secretion in Saccharomyces boulardii. Archives of microbiology. 2023 Dec; 206(1):37. doi: 10.1007/s00203-023-03773-9. [PMID: 38142245]
  • Shahrokh Bagheri, Reza Mohammadrezaei Khorramabadi, Vahideh Assadollahi, Peyman Khosravi, Ahmad Cheraghi Venol, Saeed Veiskerami, Hassan Ahmadvand. The effects of pomegranate peel extract on the gene expressions of antioxidant enzymes in a rat model of alloxan-induced diabetes. Archives of physiology and biochemistry. 2023 Dec; 129(4):870-878. doi: 10.1080/13813455.2021.1877308. [PMID: 33524274]
  • Peng Liu, Chaonan Shi, Shuang Liu, Jiajia Lei, Qisen Lu, Haichao Hu, Yan Ren, Ning Zhang, Congwei Sun, Lu Chen, Yaoyao Jiang, Lixiao Feng, Tianye Zhang, Kaili Zhong, Jiaqian Liu, Juan Zhang, Zhuo Zhang, Bingjian Sun, Jianping Chen, Yimiao Tang, Feng Chen, Jian Yang. A papain-like cysteine protease-released small signal peptide confers wheat resistance to wheat yellow mosaic virus. Nature communications. 2023 Nov; 14(1):7773. doi: 10.1038/s41467-023-43643-y. [PMID: 38012219]
  • Mehmet Salih Bakaç, Abdulahad Dogan, Mustafa Abdullah Yılmaz, Fikret Altındag, Fatih Donmez, Abdulhamit Battal. Ameliorative effects of Scutellaria Pinnatifida subsp. pichleri (Stapf) Rech.f. Extract in streptozotocin-induced diabetic rats: chemical composition, biochemical and histopathological evaluation. BMC complementary medicine and therapies. 2023 Nov; 23(1):410. doi: 10.1186/s12906-023-04252-w. [PMID: 37964249]
  • Thomas Barske, Philipp Spät, Hendrik Schubert, Peter Walke, Boris Maček, Martin Hagemann. The Role of Serine/Threonine-Specific Protein Kinases in Cyanobacteria - SpkB Is Involved in Acclimation to Fluctuating Conditions in Synechocystis sp. PCC 6803. Molecular & cellular proteomics : MCP. 2023 Nov; 22(11):100656. doi: 10.1016/j.mcpro.2023.100656. [PMID: 37797745]
  • Shanmugam Devi Bala, Ramalingam Saravanan, Gurumoorthy Mahalakshmi, Raju Murali, Natarajan Ashokkumar. Bacoside-A Improves Antioxidant Enzymes and Alleviates Oxidative Stress Coexist with Markers of Renal Function in a Rat Model of Type 2 Diabetes Mellitus. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. 2023 Nov; 34(6):537-547. doi: 10.4103/sjkdt.sjkdt_163_21. [PMID: 38725204]
  • João Medeiros-Silva, Aurelio J Dregni, Noah H Somberg, Pu Duan, Mei Hong. Atomic structure of the open SARS-CoV-2 E viroporin. Science advances. 2023 10; 9(41):eadi9007. doi: 10.1126/sciadv.adi9007. [PMID: 37831764]
  • Jianxiu Lu, Jixin Song, Peiying Zhang, Ying Huang, Xiaomin Lu, Hua Dai, Juqun Xi. Biomineralized Polydopamine Nanoparticle-Based Sodium Alginate Hydrogels for Delivery of Anti-serine/Threonine Protein Kinase B-Rapidly Accelerated Fibrosarcoma siRNA for Metastatic Melanoma Therapy. ACS nano. 2023 Sep; ?(?):. doi: 10.1021/acsnano.3c05563. [PMID: 37690074]
  • Xi Meng, Guoqi Yu, Tingyu Luo, Ruiyuan Zhang, Jun Zhang, Yongjie Liu. Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat offspring. Chemosphere. 2023 Sep; 341(?):140120. doi: 10.1016/j.chemosphere.2023.140120. [PMID: 37696479]
  • Nesrein S Salim, Mohamed Abdel-Alim, Huda E M Said, Mohamed F Foda. Phenolic Profiles, Antihyperglycemic, Anti-Diabetic, and Antioxidant Properties of Egyptian Sonchus oleraceus Leaves Extract: An In Vivo Study. Molecules (Basel, Switzerland). 2023 Sep; 28(17):. doi: 10.3390/molecules28176389. [PMID: 37687218]
  • Muhammad Idrees, Inayat U Rahman, Hamza A Khan, Yasar M Yousufzai, Ejaz H Khan, Mohammad I Khan, Saima Gul. Investigation of the effect of addition of Momordica charantia to glibenclamide on amelioration of endothelial dysfunction in diabetic rats by activating Takeda G protein-coupled receptor 5. Pakistan journal of pharmaceutical sciences. 2023 Sep; 36(5):1451-1456. doi: . [PMID: 37869921]
  • Jia-Xin Chen, Qi-Jun Fang, Yi-Gang Wan, Ying-Lu Liu, Yu Wang, Wei Wu, Yue Tu, Mei-Zi Wang, Dian-Guang Wang, Hai-Tao Ge. [Effects and mechanisms of total flavones of Abelmoschus manihot in inhibiting podocyte necroptosis and renal fibrosis in diabetic kidney disease]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Aug; 48(15):4137-4146. doi: 10.19540/j.cnki.cjcmm.20230417.701. [PMID: 37802782]
  • Hua Tang, Qiang Tang, Qian Zhang, Pengmian Feng. O-GlyThr: Prediction of human O-linked threonine glycosites using multi-feature fusion. International journal of biological macromolecules. 2023 Jul; 242(Pt 2):124761. doi: 10.1016/j.ijbiomac.2023.124761. [PMID: 37156312]
  • Asser F Bedair, Ahmed Wahid, Nesrine S El-Mezayen, Amira F El-Yazbi, Hadeel A Khalil, Nayera W Hassan, Elham A Afify. Nicorandil/ morphine crosstalk accounts for antinociception and hepatoprotection in hepatic fibrosis in rats: Distinct roles of opioid/cGMP and NO/KATP pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jun; 165(?):115068. doi: 10.1016/j.biopha.2023.115068. [PMID: 37392650]
  • Zhicheng Huang, Huijuan Cao, Huan Wang, Pengyun Huang, Jing Wang, Ying-Ying Cai, Qing Wang, Yan Li, Jiaoyu Wang, Xiao-Hong Liu, Fu-Cheng Lin, Jianping Lu. The triglyceride catabolism regulated by a serine/threonine protein phosphatase, Smek1, is required for development and plant infection in Magnaporthe oryzae. Molecular plant pathology. 2023 Jun; ?(?):. doi: 10.1111/mpp.13368. [PMID: 37357820]
  • Fan Zhang, Yunpeng Wang, Jingyang Yue, Rongrong Zhang, Yong-Er Hu, Ruoshi Huang, Ai-Jia Ji, B Andes Hess, Zhongqiu Liu, Lixin Duan, Ruibo Wu. Discovering a uniform functional trade-off of the CBC-type 2,3-oxidosqualene cyclases and deciphering its chemical logic. Science advances. 2023 06; 9(23):eadh1418. doi: 10.1126/sciadv.adh1418. [PMID: 37285431]
  • Mohammad Amin Behmanesh, Amin Rasekhian, Forutan Kiani, Mostafa Dehghandoost, Davood Alinezhad Dezfuli, Behnam Ghorbanzadeh. The nitric oxide-cyclic GMP-KATP channels pathway contributes to the effects of montelukast against gastric damage induced by ethanol. Alcohol (Fayetteville, N.Y.). 2023 Jun; ?(?):. doi: 10.1016/j.alcohol.2023.05.008. [PMID: 37295565]
  • Xiao-Di Zhai, Su-Yun Zhang, Dong Chen, Wei-Jun Li, Jin-Jun Wang, Dong Wei. Comparative multi-tissue analyses identify testis-specific serine/threonine protein kinase (TSSK) genes involved in male fertility in the melon fly Zeugodacus cucurbitae. Pest management science. 2023 Jun; 79(6):2040-2049. doi: 10.1002/ps.7378. [PMID: 36693781]
  • Mingmin Tian, Anming Yang, Qinwei Lu, Xin Zhang, Guangjie Liu, Gaofeng Liu. Study on the mechanism of Baihe Dihuang decoction in treating menopausal syndrome based on network pharmacology. Medicine. 2023 May; 102(20):e33189. doi: 10.1097/md.0000000000033189. [PMID: 37335709]
  • Kyeong-Eon Park, Soo Hee Lee, Sung Il Bae, Yeran Hwang, Seong-Ho Ok, Dawon Kang, Seung Hyun Ahn, Gyujin Sim, Jin Kyeong Park, Ju-Tae Sohn. Chloroquine inhibits vasodilation induced by ATP-sensitive potassium channels in isolated rat aorta. General physiology and biophysics. 2023 May; 42(3):297-306. doi: 10.4149/gpb_2023008. [PMID: 37098743]
  • Yong Zhuo, Xiangyang Zou, Ya Wang, Xuemei Jiang, Mengmeng Sun, Shengyu Xu, Yan Lin, Lun Hua, Jian Li, Bin Feng, Zhengfeng Fang, Lianqiang Che, De Wu. Standardized ileal digestibility of amino acids in cottonseed meal fed to pregnant and non-pregnant sows. Journal of animal science. 2023 Apr; ?(?):. doi: 10.1093/jas/skad132. [PMID: 37119089]
  • Ajay Guru, Gokul Sudhakaran, S Karthick Raja Namasivayam, Boopathi Seenivasan, Mukesh Pasupulieti, Jesu Arockiaraj, Meivelu Moovendhan. Serine Threonine-Protein Kinase-Derived IW13 Improves Lipid Metabolism via C/EBP-α/SREBP1/FAS Signaling Pathways in HFD-Induced Zebrafish In Vivo Larval Model. Applied biochemistry and biotechnology. 2023 Apr; ?(?):. doi: 10.1007/s12010-023-04480-3. [PMID: 37079270]
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