Xanthoxylin (BioDeep_00000230839)

 

Secondary id: BioDeep_00000003896, BioDeep_00000863679

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


2 inverted exclamation mark -Hydroxy-4 inverted exclamation mark ,6 inverted exclamation mark -dimethoxyacetophenone

化学式: C10H12O4 (196.0736)
中文名称: 花椒素, 4',6-二甲基-2-羟基苯乙酮, 2-羟基-4,6-二甲氧基苯乙酮, 黄嘌呤, 花椒油素
谱图信息: 最多检出来源 Homo sapiens(otcml) 3.14%

分子结构信息

SMILES: c1(cc(cc(c1C(=O)C)O)OC)OC
InChI: InChI=1S/C10H12O4/c1-6(11)10-8(12)4-7(13-2)5-9(10)14-3/h4-5,12H,1-3H3

描述信息

obtained from Zanthoxylum piperitum (Japanese pepper tree) and Sapium sebiferum (Chinese tallowtree). Xanthoxylin is found in many foods, some of which are herbs and spices, german camomile, fats and oils, and pomegranate.
Xanthoxylin is a carboxylic ester. It is functionally related to a phloroglucinol.
Xanthoxylin is a natural product found in Euphorbia portulacoides, Pulicaria incisa, and other organisms with data available.
Xanthoxylin is found in fats and oils. Xanthoxylin is obtained from Zanthoxylum piperitum (Japanese pepper tree) and Sapium sebiferum (Chinese tallowtree
Xanthoxylin (Xanthoxyline) is isolated from Zanthoxylum simulans. Xanthoxylin (Xanthoxyline) has antifungal and antispasmodic activities[1][2].
Xanthoxylin (Xanthoxyline) is isolated from Zanthoxylum simulans. Xanthoxylin (Xanthoxyline) has antifungal and antispasmodic activities[1][2].

同义名列表

54 个代谢物同义名

2 inverted exclamation mark -Hydroxy-4 inverted exclamation mark ,6 inverted exclamation mark -dimethoxyacetophenone; Ethanone, 1-(2-hydroxy-4,6-dimethoxyphenyl)-; Acetophenone, 2-hydroxy-4,6-dimethoxy- (8CI); 1-(2-Hydroxy-4,6-dimethoxyphenyl)ethan-1-one; 1-(2-Hydroxy-4,6-dimethoxyphenyl)ethanone #; Ethanone,1-(2-hydroxy-4,6-dimethoxyphenyl)-; 1-(2-hydroxy-4,6-dimethoxyphenyl)-ethanone; 1-(2-hydroxy-4,6-dimethoxy-phenyl)ethanone; (2-hydroxy-4,6-dimethoxy-phenyl)-ethanone; 2-Hydroxy-4,6-dimethoxyacetophenone, 97\\%; 1-(2-Hydroxy-4,6-dimethoxyphenyl)ethanone; 1-(2-Hydroxy-4,6-dimethylphenyl)-ethanone; 1-Acetyl-2-hydroxy-4,6-dimethoxybenzene; Acetophenone, 2-hydroxy-4,6-dimethoxy-; 2-Hydroxyl-4,6-dimethoxy-acetophenone; Phloroacetophenone 2,4-dimethyl ether; 2-Hydroxy-4,6-dimethoxy-Acetophenone; 2-Hydroxy-4, 6-dimethoxyacetophenone; 4, 6-Dimethoxy-2-hydroxyacetophenone; 4,6-dimethoxy-2-hydroxyacetophenone; 4,6-Dimethoxy-2-hydroxyacetophenone; 2-hydroxy-4,6-dimethoxyacetophenone; 2,4-DIMETHOXY-6-HYDROXYACETOPHENONE; 2-Hydroxy-4,6-dimethoxyacetophenone; 2-hyroxy-4,6-dimethoxyacetophenone; 2,4-Di-O-methylphloroacetophenone; PHLOROACETOPHENONE DIMETHYL ETHER; Phloracetophenone dimethyl ether; 2-Acetyl-3,5-dimethoxyphenol; Acetophenone,6-dimethoxy-; Brevifolin (Zanthoxylum); XANTHOXYLINE [WHO-DD]; Acetophenone der.; XANTHOXYLIN [MI]; Spectrum2_000463; Spectrum5_000237; Spectrum4_001499; Brevifolin (VAN); 6-Methoxypaeonol; Spectrum3_000181; UNII-Z8RSY5TZPA; DivK1c_006809; KBio3_001201; Xanthoxyline; KBio1_001753; KBio2_003625; KBio2_001057; KBio2_006193; Xanthoxylin; brevifolin; Z8RSY5TZPA; AI3-26010; Xanthoxylin; Xanthoxylin



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

117 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AKT1, CAT, CDH1, FPR1, FPR2, MTOR, RPL32, SLC9A1, VIM, XDH
Peripheral membrane protein 3 ACHE, GORASP1, MTOR
Endoplasmic reticulum membrane 2 HSP90B1, MTOR
Nucleus 8 ACD, ACHE, AKT1, CDH1, HSP90B1, KDR, MTOR, PARP1
cytosol 9 AKT1, CAT, CDH1, HSP90B1, MTOR, PARP1, RPL32, VIM, XDH
dendrite 1 MTOR
nuclear body 2 ACD, PARP1
phagocytic vesicle 2 MTOR, VIM
trans-Golgi network 1 CDH1
nucleoplasm 6 ACD, AKT1, CDH1, MTOR, PARP1, SLC9A1
Cell membrane 8 ACHE, AKT1, CDH1, FPR1, FPR2, KDR, SLC9A1, VIM
Cytoplasmic side 2 GORASP1, MTOR
lamellipodium 3 AKT1, CDH1, SLC9A1
Multi-pass membrane protein 3 FPR1, FPR2, SLC9A1
Golgi apparatus membrane 2 GORASP1, MTOR
Synapse 1 ACHE
cell cortex 1 AKT1
cell junction 2 CDH1, KDR
cell surface 2 ACHE, SLC9A1
glutamatergic synapse 2 AKT1, CDH1
Golgi apparatus 4 ACHE, CDH1, GORASP1, KDR
Golgi membrane 2 GORASP1, MTOR
lysosomal membrane 1 MTOR
neuromuscular junction 1 ACHE
postsynapse 2 AKT1, CDH1
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 PARP1
Lysosome 1 MTOR
endosome 2 CDH1, KDR
plasma membrane 9 ACHE, AKT1, BCHE, CDH1, FPR1, FPR2, KDR, SLC9A1, VIM
Membrane 11 ACHE, AKT1, CAT, CDH1, FPR1, FPR2, HSP90B1, MTOR, PARP1, RPL32, SLC9A1
apical plasma membrane 1 SLC9A1
axon 1 VIM
basolateral plasma membrane 1 SLC9A1
extracellular exosome 5 CAT, CDH1, HSP90B1, SLC9A1, VIM
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 HSP90B1, KDR
extracellular space 6 ACHE, BCHE, CXCL8, IL10, IL6, XDH
perinuclear region of cytoplasm 4 ACHE, CDH1, HSP90B1, SLC9A1
adherens junction 1 CDH1
intercalated disc 1 SLC9A1
mitochondrion 3 CAT, PARP1, SLC9A1
protein-containing complex 4 AKT1, CAT, HSP90B1, PARP1
intracellular membrane-bounded organelle 1 CAT
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 CDH1
Secreted 5 ACHE, BCHE, CXCL8, IL10, IL6
extracellular region 9 ACHE, BCHE, CAT, CDH1, CXCL8, HSP90B1, IL10, IL6, KDR
cytoplasmic side of plasma membrane 1 CDH1
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
[Isoform 2]: Secreted 1 KDR
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
anchoring junction 1 KDR
transcription regulator complex 1 PARP1
nuclear membrane 1 CDH1
external side of plasma membrane 1 KDR
actin cytoskeleton 1 CDH1
T-tubule 1 SLC9A1
microtubule cytoskeleton 1 AKT1
nucleolus 1 PARP1
midbody 1 HSP90B1
Early endosome 1 KDR
cell-cell junction 1 AKT1
vesicle 1 AKT1
Membrane raft 2 KDR, SLC9A1
Cytoplasm, cytoskeleton 1 VIM
focal adhesion 4 CAT, HSP90B1, SLC9A1, VIM
spindle 1 AKT1
cis-Golgi network 1 GORASP1
Cell junction, adherens junction 1 CDH1
flotillin complex 1 CDH1
Peroxisome 3 CAT, VIM, XDH
basement membrane 1 ACHE
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 HSP90B1
intermediate filament 1 VIM
lateral plasma membrane 1 CDH1
receptor complex 1 KDR
neuron projection 1 VIM
ciliary basal body 1 AKT1
chromatin 1 PARP1
cell leading edge 1 VIM
Chromosome 1 PARP1
cytoskeleton 1 VIM
Golgi apparatus, trans-Golgi network 1 CDH1
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
Chromosome, telomere 1 ACD
chromosome, telomeric region 2 ACD, PARP1
blood microparticle 1 BCHE
Basolateral cell membrane 1 SLC9A1
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 PARP1
nuclear envelope 2 MTOR, PARP1
Endomembrane system 1 MTOR
sorting endosome 1 KDR
microtubule organizing center 1 VIM
specific granule membrane 1 FPR2
tertiary granule membrane 1 FPR2
Melanosome 1 HSP90B1
side of membrane 1 ACHE
sperm plasma membrane 1 HSP90B1
intermediate filament cytoskeleton 1 VIM
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
secretory granule membrane 1 FPR1
endoplasmic reticulum lumen 3 BCHE, HSP90B1, IL6
nuclear matrix 1 VIM
azurophil granule membrane 1 FPR1
anaphase-promoting complex 1 CDH1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Nucleus matrix 1 VIM
nuclear envelope lumen 1 BCHE
nuclear telomere cap complex 1 ACD
telomerase holoenzyme complex 1 ACD
Sarcoplasmic reticulum lumen 1 HSP90B1
ribonucleoprotein complex 1 RPL32
[Isoform 2]: Nucleus 1 CDH1
synaptic cleft 1 ACHE
protein-DNA complex 1 PARP1
ficolin-1-rich granule membrane 2 FPR1, FPR2
apical junction complex 1 CDH1
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
Cytoplasmic vesicle, phagosome 1 MTOR
cytosolic ribosome 1 RPL32
catenin complex 1 CDH1
site of DNA damage 1 PARP1
endocytic vesicle lumen 1 HSP90B1
ribosome 1 RPL32
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
cytosolic large ribosomal subunit 1 RPL32
endoplasmic reticulum chaperone complex 1 HSP90B1
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
cation-transporting ATPase complex 1 SLC9A1
[Isoform H]: Cell membrane 1 ACHE
shelterin complex 1 ACD


文献列表

  • Carmen Rossini, Lucía Almeida, Daniela Arredondo, Karina Antúnez, Estela Santos, Alejandra Rodríguez Haralambides, Ciro Invernizzi. When a Tritrophic Interaction Goes Wrong to the Third Level: Xanthoxylin From Trees Causes the Honeybee Larval Mortality in Colonies Affected by the River Disease. Journal of chemical ecology. 2021 Sep; 47(8-9):777-787. doi: 10.1007/s10886-021-01296-5. [PMID: 34287796]
  • Chun-Ling Zhu. [Chemical constituents of n-BuOH extract from Phyllanthus matsumurae]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 Apr; 37(4):608-10. doi: . [PMID: 25345134]
  • Congzhou Wang, Jianhua Wang, Linhong Deng. Evaluating interaction forces between BSA and rabbit anti-BSA in sulphathiazole sodium, tylosin and levofloxacin solution by AFM. Nanoscale research letters. 2011 Nov; 6(1):579. doi: 10.1186/1556-276x-6-579. [PMID: 22053876]
  • Wenjuan Feng, Yang Fa Ou, Yalun Su, Jin Li, Tengfei Ji. [Chemical constituents of Ammopiptanthus mongolicus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Apr; 36(8):1040-2. doi: . [PMID: 21809581]
  • Ying Tian, Limin Sun, Xiqiao Liu, Junxing Dong. [Phenols from Euphorbia humifusa]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Mar; 35(5):613-5. doi: 10.4268/cjcmm20100516. [PMID: 20506823]
  • Joo Hyuk Yim, Ok-Hwan Lee, Ung-Kyu Choi, Young-Chan Kim. Antinociceptive and anti-inflammatory effects of ethanolic extracts of Glycine max (L.) Merr and Rhynchosia nulubilis seeds. International journal of molecular sciences. 2009 Nov; 10(11):4742-4753. doi: 10.3390/ijms10114742. [PMID: 20087462]
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  • Xiao-Feng Niu, Lang-Chong He, Te Fan, Yan Li. [Protecting effect of brevifolin and 8,9-single-epoxy brevifolin of Phyllanthus simplex on rat liver injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 Sep; 31(18):1529-32. doi: . [PMID: 17144473]
  • Xin-Hong Shi, Xiao-Li Du, Ling-Yi Kong. [Studies on chemical constituents in roots of Euphorbia soongarica]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 Sep; 31(18):1503-6. doi: . [PMID: 17144466]
  • Henrik Toft Simonsen, Anne Adsersen, Paul Bremner, Michael Heinrich, Ulla Wagner Smitt, Jerzy W Jaroszewski. Antifungal constituents of Melicope borbonica. Phytotherapy research : PTR. 2004 Jul; 18(7):542-5. doi: 10.1002/ptr.1482. [PMID: 15305313]
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