Liquiritin (BioDeep_00000000026)

 

Secondary id: BioDeep_00000270465, BioDeep_00000863546

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


(2S)-7-hydroxy-2-(4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-3,4-dihydro-2H-1-benzopyran-4-one

化学式: C21H22O9 (418.1264)
中文名称: 甘草苷
谱图信息: 最多检出来源 Viridiplantae(plant) 35.94%

Reviewed

Last reviewed on 2024-07-03.

Cite this Page

Liquiritin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/liquiritin (retrieved 2024-12-23) (BioDeep RN: BioDeep_00000000026). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O
InChI: InChI=1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2

描述信息

Liquiritin is a flavanone glycoside that is liquiritigenin attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage. It has a role as a plant metabolite, an anticoronaviral agent and an anti-inflammatory agent. It is a flavanone glycoside, a beta-D-glucoside, a monosaccharide derivative and a monohydroxyflavanone. It is functionally related to a liquiritigenin.
Liquiritin is a natural product found in Polygonum aviculare, Artemisia capillaris, and other organisms with data available.
See also: Glycyrrhiza Glabra (part of); Glycyrrhiza uralensis Root (part of).
Liquiritin is found in herbs and spices. Liquiritin is isolated from Glycyrrhiza glabra (licorice) and Glycyrrhiza uralensis (Chinese licorice
Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo[1]. Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity[2].
Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo[1]. Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity[2].

同义名列表

34 个代谢物同义名

(2S)-7-hydroxy-2-(4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-3,4-dihydro-2H-1-benzopyran-4-one; (S)-7-hydroxy-2-(4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)phenyl)chroman-4-one; (S)-7-Hydroxy-2-[4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-chroman-4-one; (2S)-7-hydroxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxyphenyl]chroman-4-one; (S)-7-Hydroxy-2-[4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyltetrahydropyran-2-yloxy)phenyl]chroman-4-one; 7-hydroxy-2-(4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-3,4-dihydro-2H-1-benzopyran-4-one; 7-hydroxy-2-(4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-2,3-dihydro-1-benzopyran-4-one; 4H-1-BENZOPYRAN-4-ONE, 2-(4-(.BETA.-D-GLUCOPYRANOSYLOXY)PHENYL)-2,3-DIHYDRO-7-HYDROXY-, (2S)-; 4H-1-benzopyran-4-one, 2-(4-(beta-D-glucopyranosyloxy)phenyl)-2,3-dihydro-7-hydroxy-, (2S)-; 4H-1-Benzopyran-4-one, 2-(4-(beta-D-glucopyranosyloxy)phenyl)-2,3-dihydro-7-hydroxy-, (S)-; 4H-1-Benzopyran-4-one, 2-[4-(?-D-glucopyranosyloxy)phenyl]-2,3-dihydro-7-hydroxy-, (2S)-; 4H-1-Benzopyran-4-one,2-[4-(b-D-glucopyranosyloxy)phenyl]-2,3-dihydro-7-hydroxy-, (2S)-; 4-[(2S)-7-hydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-2-yl]phenyl beta-D-glucopyranoside; 4-((2S)-7-hydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-2-yl)phenyl beta-D-glucopyranoside; (S)-2-(4-(beta-D-Glucopyranosyloxy)phenyl)-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one; 4,7-Dihydroxyflavanone 4-(beta-D-glucopyranoside); 4-O-beta-D-glucopyranosyl-7-hydroxyflavan-4-one; 4,7-Dihydroxyflavanone 4-(beta-D-glucoside); liquiritigenin 4-O-beta-D-glucopyranoside; LIQUIRITIGENIN 4-.BETA.-D-GLUCOPYRANOSIDE; LIQUIRITIGENIN 4-beta-D-GLUCOPYRANOSIDE; 7-hydroxyflavanone 4-O-beta-D-glucoside; liquiritigenin-4-beta-D-glucoside; 7-hydroxyflavanone 4-O-glucoside; Liquiritigenin-4-beta-glucoside; Liquiritigenin-4-O-glucoside; DEMKZLAVQYISIA-ZRWXNEIDSA-N; UNII-T0O79T74CD; liquiritoside; likviritin; Liquiritin; Likviriton; T0O79T74CD; Liquiritin



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

104 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ABCB1, AIMP2, BCL2, BDNF, CASP3, CDKN1A, KEAP1, MAPK8, PIK3CA, PTGS2, TLR4, TP53, VEGFA
Peripheral membrane protein 2 GORASP1, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 11 AIMP2, BCL2, CASP3, CDKN1A, GABPA, JUN, KEAP1, MAPK8, PARP1, TP53, VEGFA
cytosol 9 AIMP2, BCL2, CASP3, CDKN1A, KEAP1, MAPK8, PARP1, PIK3CA, TP53
dendrite 1 BDNF
nuclear body 2 CDKN1A, PARP1
centrosome 1 TP53
nucleoplasm 8 CASP3, CDKN1A, GABPA, JUN, KEAP1, MAPK8, PARP1, TP53
RNA polymerase II transcription regulator complex 1 JUN
Cell membrane 3 ABCB1, TLR4, TNF
Cytoplasmic side 1 GORASP1
lamellipodium 1 PIK3CA
Multi-pass membrane protein 1 ABCB1
Golgi apparatus membrane 1 GORASP1
Synapse 1 MAPK8
cell surface 4 ABCB1, TLR4, TNF, VEGFA
glutamatergic synapse 1 CASP3
Golgi apparatus 2 GORASP1, VEGFA
Golgi membrane 2 GORASP1, INS
neuronal cell body 2 CASP3, TNF
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 2 AIMP2, PARP1
plasma membrane 4 ABCB1, PIK3CA, TLR4, TNF
Membrane 8 ABCB1, AIMP2, BCL2, BDNF, PARP1, TLR4, TP53, VEGFA
apical plasma membrane 1 ABCB1
axon 2 BDNF, MAPK8
caveola 1 PTGS2
extracellular exosome 1 ABCB1
endoplasmic reticulum 5 BCL2, KEAP1, PTGS2, TP53, VEGFA
extracellular space 5 BDNF, IL6, INS, TNF, VEGFA
perinuclear region of cytoplasm 4 BDNF, CDKN1A, PIK3CA, TLR4
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, PARP1, TP53
protein-containing complex 5 BCL2, CDKN1A, PARP1, PTGS2, TP53
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 TLR4
Secreted 4 BDNF, IL6, INS, VEGFA
extracellular region 5 BDNF, IL6, INS, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 3 JUN, PARP1, TP53
centriolar satellite 1 KEAP1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 TLR4, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
nucleolus 3 CDKN1A, PARP1, TP53
midbody 1 KEAP1
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ABCB1
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
cis-Golgi network 1 GORASP1
extracellular matrix 1 VEGFA
Nucleus, PML body 1 TP53
PML body 1 TP53
secretory granule 1 VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 1 PTGS2
chromatin 4 GABPA, JUN, PARP1, TP53
phagocytic cup 2 TLR4, TNF
Chromosome 1 PARP1
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
nuclear chromosome 1 JUN
actin filament 1 KEAP1
site of double-strand break 2 PARP1, TP53
Cul3-RING ubiquitin ligase complex 1 KEAP1
nuclear envelope 1 PARP1
endosome lumen 1 INS
euchromatin 1 JUN
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
lipopolysaccharide receptor complex 1 TLR4
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 BDNF, IL6, INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 PARP1
external side of apical plasma membrane 1 ABCB1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
site of DNA damage 1 PARP1
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
transcription factor AP-1 complex 1 JUN
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
inclusion body 1 KEAP1
interleukin-6 receptor complex 1 IL6
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
PCNA-p21 complex 1 CDKN1A
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Peijun Sun, Huixian Chen, Xiaoyu Fan, Jiayi Wang, Lujie Lu, Guangchao Yang, Jining Liu, Weifeng Yao, Feng Ding, Jie Ding, Jianmei Liu, Tulin Lu, Lihong Chen. Exploring the effective components of honey-processed licorice (Glycyrrhiza uralensis Fisch.) in attenuating Doxorubicin-induced myocardial cytotoxicity by combining network pharmacology and in vitro experiments. Journal of ethnopharmacology. 2024 Jul; 329(?):118178. doi: 10.1016/j.jep.2024.118178. [PMID: 38604511]
  • Min Qiu, Liangyan Cheng, Jianbo Xu, Minwei Jin, Wenhua Yuan, Qinwen Ge, Kaiao Zou, Jiali Chen, Yuliang Huang, Ju Li, Liming Zhu, Bing Xu, Chunchun Zhang, Hongting Jin, Pinger Wang. Liquiritin reduces chondrocyte apoptosis through P53/PUMA signaling pathway to alleviate osteoarthritis. Life sciences. 2024 Apr; 343(?):122536. doi: 10.1016/j.lfs.2024.122536. [PMID: 38423170]
  • Xichun Xia, Yingying Zhang, Leqing Zhu, Yin Ying, Wenzhi Hao, Lu Wang, Liangliang He, Danyue Zhao, Jia-Xu Chen, Yunfei Gao, Jun-Qing Huang. Liquiritin apioside alleviates colonic inflammation and accompanying depression-like symptoms in colitis by gut metabolites and the balance of Th17/Treg. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Nov; 120(?):155039. doi: 10.1016/j.phymed.2023.155039. [PMID: 37672855]
  • Tong-Juan Tang, Xiang Wang, Liang Wang, Ming Chen, Jing Cheng, Meng-Yu Zuo, Jin-Fan Gu, Rui Ding, Peng Zhou, Jin-Ling Huang. Liquiritin inhibits H2 O2 -induced oxidative stress injury in H9c2 cells via the AMPK/SIRT1/NF-κB signaling pathway. Journal of food biochemistry. 2022 10; 46(10):e14351. doi: 10.1111/jfbc.14351. [PMID: 35929638]
  • Junyuan Qin, Junren Chen, Fu Peng, Chen Sun, Yu Lei, Guangru Chen, Gangming Li, Yanpeng Yin, Ziwei Lin, Liujun Wu, Jing Li, Wenxiu Liu, Cheng Peng, Xiaofang Xie. Pharmacological activities and pharmacokinetics of liquiritin: A review. Journal of ethnopharmacology. 2022 Jul; 293(?):115257. doi: 10.1016/j.jep.2022.115257. [PMID: 35395381]
  • Quan Bi, Hua Yao, Fei Wang, Dajun He, Wenbin Xu, Shuangquan Xie, Xifeng Chen, Yuxia Li, Hailiang Liu, Haitao Shen, Hongbin Li. Integrative analysis of the pharmaceutical active ingredient and transcriptome of the aerial parts of Glycyrrhiza uralensis under salt stress reveals liquiritin accumulation via ABA-mediated signaling. Molecular genetics and genomics : MGG. 2022 Mar; 297(2):333-343. doi: 10.1007/s00438-021-01847-1. [PMID: 35187583]
  • Meina Gao, Hui Li, Chenghao Ye, Kaixian Chen, Hualiang Jiang, Kunqian Yu. Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico Study. Biomolecules. 2021 10; 11(11):. doi: 10.3390/biom11111586. [PMID: 34827585]
  • Yuanjie Li, Changbo Xia, Guangda Yao, Xia Zhang, Jianjun Zhao, Xiaojuan Gao, Jingjiao Yong, Hanqing Wang. Protective effects of liquiritin on UVB-induced skin damage in SD rats. International immunopharmacology. 2021 Aug; 97(?):107614. doi: 10.1016/j.intimp.2021.107614. [PMID: 33892299]
  • Shan Jiang, Shaoping Wang, Pingping Dong, Lei Shi, Qiyan Li, Xia Wei, Peng Gao, Jiayu Zhang. A comprehensive profiling and identification of liquiritin metabolites in rats using ultra-high-performance liquid chromatography coupled with linear ion trap-orbitrap mass spectrometer. Xenobiotica; the fate of foreign compounds in biological systems. 2021 May; 51(5):564-581. doi: 10.1080/00498254.2020.1854366. [PMID: 33222601]
  • Zibin Lu, Huihui Cao, Dongyi Liu, Yuanru Zheng, Chunyang Tian, Shanhong Liu, Jingyu Quan, Lingzhu Shi, Junshan Liu, Linzhong Yu. Optimal combination of anti-inflammatory components from Chinese medicinal formula Liang-Ge-San. Journal of ethnopharmacology. 2021 Apr; 269(?):113747. doi: 10.1016/j.jep.2020.113747. [PMID: 33359185]
  • Yahang Wang, Yuanyuan Li, Hua Zhang, Leilei Zhu, Jie Zhong, Jiakai Zeng, Cong Meng, Jiasheng Wu, Tianming Wang, Rong Shi, Weian Yuan, Jian Jiang, Ping Liu, Yueming Ma. Pharmacokinetics-based comprehensive strategy to identify multiple effective components in Huangqi decoction against liver fibrosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Apr; 84(?):153513. doi: 10.1016/j.phymed.2021.153513. [PMID: 33647776]
  • Jianwei Dou, Zhongbo Zhu, Yan Li, Shuo Yang, Zhanzi Guo, Kangle Li, Cuicui Ren, Linhong Huang, Jianyu He. Development and evaluation of poly adenosine 5'-diphosphate-ribose polymerase 1 immobilization-based receptor chromatography. Journal of separation science. 2021 Feb; 44(4):793-804. doi: 10.1002/jssc.202000856. [PMID: 33275824]
  • Wen Weng, Qilong Wang, Chunmei Wei, Michael Adu-Frimpong, Elmurat Toreniyazov, Hao Ji, Jiangnan Yu, Ximing Xu. Mixed micelles for enhanced oral bioavailability and hypolipidemic effect of liquiritin: preparation, in vitro and in vivo evaluation. Drug development and industrial pharmacy. 2021 Feb; 47(2):308-318. doi: 10.1080/03639045.2021.1879839. [PMID: 33494627]
  • Peiqing Liu, Yushan Cai, Jinzhu Zhang, Rongbo Wang, Benjin Li, Qiyong Weng, Qinghe Chen. Antifungal activity of liquiritin in Phytophthora capsici comprises not only membrane-damage-mediated autophagy, apoptosis, and Ca2+ reduction but also an induced defense responses in pepper. Ecotoxicology and environmental safety. 2021 Feb; 209(?):111813. doi: 10.1016/j.ecoenv.2020.111813. [PMID: 33360212]
  • Xiao Li, Xuemei Qin, Junsheng Tian, Xiaoxia Gao, Xingkang Wu, Guanhua Du, Yuzhi Zhou. Liquiritin protects PC12 cells from corticosterone-induced neurotoxicity via regulation of metabolic disorders, attenuation ERK1/2-NF-κB pathway, activation Nrf2-Keap1 pathway, and inhibition mitochondrial apoptosis pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Dec; 146(?):111801. doi: 10.1016/j.fct.2020.111801. [PMID: 33035630]
  • Tianyang Wang, Song Lin, Hua Li, Ran Liu, Zihan Liu, Huarong Xu, Qing Li, Kaishun Bi. A stepwise integrated multi-system to screen quality markers of Chinese classic prescription Qingzao Jiufei decoction on the treatment of acute lung injury by combining 'network pharmacology-metabolomics-PK/PD modeling'. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Nov; 78(?):153313. doi: 10.1016/j.phymed.2020.153313. [PMID: 32866904]
  • Zhi-Qiang Yan, Jing Tan, Kai Guo, Lun-Guang Yao. Phytotoxic mechanism of allelochemical liquiritin on root growth of lettuce seedlings. Plant signaling & behavior. 2020 Oct; 15(10):1795581. doi: 10.1080/15592324.2020.1795581. [PMID: 32693669]
  • Xin-Yi Lan, Hui Yu, Qiu-Jing Chen, Shuo Zhai, Chun-Feng Zhang, Fei Li, Chong-Zhi Wang, Chun-Su Yuan. Effect of liquiritin on neuroendocrine-immune network in menopausal rat model. Phytotherapy research : PTR. 2020 Oct; 34(10):2665-2674. doi: 10.1002/ptr.6696. [PMID: 32281178]
  • Hao Wang, Hu Shan, Haitao Lü. Preparative Separation and Purification of Liquiritin and Glycyrrhizic Acid from Glycyrrhiza uralensis Fisch by High-Speed Countercurrent Chromatography. Journal of chromatographic science. 2020 Sep; 58(9):823-830. doi: 10.1093/chromsci/bmaa050. [PMID: 32869089]
  • Hanli Dang, Tao Zhang, Guifang Li, Yudi Mu, Xinhua Lv, Zhongke Wang, Li Zhuang. Root-associated endophytic bacterial community composition and structure of three medicinal licorices and their changes with the growing year. BMC microbiology. 2020 09; 20(1):291. doi: 10.1186/s12866-020-01977-3. [PMID: 32957914]
  • Min Chen, Qiu-Ping Zhang, Ji-Xiao Zhu, Jie Cheng, Qing Liu, Guang-Hui Xu, Cheng-Fu Li, Li-Tao Yi. Involvement of FGF-2 modulation in the antidepressant-like effects of liquiritin in mice. European journal of pharmacology. 2020 Aug; 881(?):173297. doi: 10.1016/j.ejphar.2020.173297. [PMID: 32580037]
  • Lin Zhang, Chen-Xiang Wang, Jing Wu, Tian-Yun Wang, Qiao-Qiao Zhong, Yan Du, Shuai Ji, Liang Wang, Meng-Zhe Guo, Sheng-Qiu Xu, Dao-Quan Tang. Metabolic profiling of mice plasma, bile, urine and feces after oral administration of two licorice flavonones. Journal of ethnopharmacology. 2020 Jul; 257(?):112892. doi: 10.1016/j.jep.2020.112892. [PMID: 32320727]
  • Jina Yang, Wenbin Jin, Danyang Liu, Qisheng Zhong, Ting Zhou. Enhanced pseudotargeted analysis using a segment data dependent acquisition strategy by liquid chromatography-tandem mass spectrometry for a metabolomics study of liquiritin in the treatment of depression. Journal of separation science. 2020 Jun; 43(11):2088-2096. doi: 10.1002/jssc.202000107. [PMID: 32144949]
  • Pengcheng Huang, Yinghong Tang, Chang Li, Huifen Zhou, Li Yu, Haitong Wan, Yu He. Correlation study between the pharmacokinetics of seven main active ingredients of Mahuang decoction and its pharmacodynamics in asthmatic rats. Journal of pharmaceutical and biomedical analysis. 2020 May; 183(?):113144. doi: 10.1016/j.jpba.2020.113144. [PMID: 32070931]
  • Waheed Akram, Taiba Saeed, Aqeel Ahmad, Nasim A Yasin, Muhammad Akbar, Waheed U Khan, Shakeel Ahmed, Juxian Guo, Wenlong Luo, Tingquan Wu, Guihua Li. Liquiritin elicitation can increase the content of medicinally important glucosinolates and phenolic compounds in Chinese kale plants. Journal of the science of food and agriculture. 2020 Mar; 100(4):1616-1624. doi: 10.1002/jsfa.10170. [PMID: 31773731]
  • Qiuyan Guo, Koji Mizuno, Katsuki Okuyama, Na Lin, Yanqiong Zhang, Hideki Hayashi, Norio Takagi, Takashi Sato. Antineuropathic pain actions of Wu-tou decoction resulted from the increase of neurotrophic factor and decrease of CCR5 expression in primary rat glial cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Mar; 123(?):109812. doi: 10.1016/j.biopha.2020.109812. [PMID: 31945696]
  • Kang Uk Kim, Sung-Jin Lee, Inhyung Lee. Development of an Improved Menopausal Symptom-Alleviating Licorice (Glycyrrhiza uralensis) by Biotransformation Using Monascus albidulus. Journal of microbiology and biotechnology. 2020 Feb; 30(2):178-186. doi: 10.4014/jmb.1909.09037. [PMID: 31752065]
  • Jun Jiang, Shichang Xiao, Shu Yan, Jianpeng Xiao, Ximing Xu. Glycyrrhizae Radix et Rhizoma Processed by Sulfur Fumigation Damaged the Chemical Profile Accompanied by Immunosuppression and Liver Injury. BioMed research international. 2020; 2020(?):5439853. doi: 10.1155/2020/5439853. [PMID: 32090097]
  • Zhenlin Huang, Qing Zhao, Minwei Chen, Jingnan Zhang, Lili Ji. Liquiritigenin and liquiritin alleviated monocrotaline-induced hepatic sinusoidal obstruction syndrome via inhibiting HSP60-induced inflammatory injury. Toxicology. 2019 12; 428(?):152307. doi: 10.1016/j.tox.2019.152307. [PMID: 31589899]
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