likviritin (BioDeep_00000863546)

Main id: BioDeep_00000270465

 

PANOMIX_OTCML-2023


代谢物信息卡片


(2S)-7-hydroxy-2-[4-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]phenyl]-4-chromanone

化学式: C21H22O9 (418.1263762)
中文名称: 甘草苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O
InChI: InChI=1S/C21H22O9/c22-9-17-18(25)19(26)20(27)21(30-17)28-12-4-1-10(2-5-12)15-8-14(24)13-6-3-11(23)7-16(13)29-15/h1-7,15,17-23,25-27H,8-9H2/t15-,17+,18+,19-,20+,21+/m0/s1

描述信息

Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo[1]. Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity[2].
Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo[1]. Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity[2].

同义名列表

22 个代谢物同义名

(2S)-7-hydroxy-2-[4-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]phenyl]-4-chromanone; (S)-7-Hydroxy-2-[4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-chroman-4-one; (2S)-7-hydroxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxyphenyl]chroman-4-one; (2S)-7-hydroxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxyphenyl]chroman-4-one; (2S)-7-hydroxy-2-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]chroman-4-one; 4H-1-Benzopyran-4-one, 2-(4-(beta-D-glucopyranosyloxy)phenyl)-2,3-dihydro-7-hydroxy-, (S)-; (S)-2-(4-(beta-D-Glucopyranosyloxy)phenyl)-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one; 4,7-Dihydroxyflavanone 4-(beta-D-glucopyranoside); 4,7-Dihydroxyflavanone 4-(beta-D-glucoside); 7-hydroxyflavanone 4-O-glucoside; liquiritoside; SMR000232362; MLS000575018; 100483-53-2; AIDS-166098; likviritin; AIDS166098; Liquiritin; 31564-20-2; 17654-21-6; 30372-08-8; 551-15-5



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Peijun Sun, Huixian Chen, Xiaoyu Fan, Jiayi Wang, Lujie Lu, Guangchao Yang, Jining Liu, Weifeng Yao, Feng Ding, Jie Ding, Jianmei Liu, Tulin Lu, Lihong Chen. Exploring the effective components of honey-processed licorice (Glycyrrhiza uralensis Fisch.) in attenuating Doxorubicin-induced myocardial cytotoxicity by combining network pharmacology and in vitro experiments. Journal of ethnopharmacology. 2024 Jul; 329(?):118178. doi: 10.1016/j.jep.2024.118178. [PMID: 38604511]
  • Min Qiu, Liangyan Cheng, Jianbo Xu, Minwei Jin, Wenhua Yuan, Qinwen Ge, Kaiao Zou, Jiali Chen, Yuliang Huang, Ju Li, Liming Zhu, Bing Xu, Chunchun Zhang, Hongting Jin, Pinger Wang. Liquiritin reduces chondrocyte apoptosis through P53/PUMA signaling pathway to alleviate osteoarthritis. Life sciences. 2024 Apr; 343(?):122536. doi: 10.1016/j.lfs.2024.122536. [PMID: 38423170]
  • Xichun Xia, Yingying Zhang, Leqing Zhu, Yin Ying, Wenzhi Hao, Lu Wang, Liangliang He, Danyue Zhao, Jia-Xu Chen, Yunfei Gao, Jun-Qing Huang. Liquiritin apioside alleviates colonic inflammation and accompanying depression-like symptoms in colitis by gut metabolites and the balance of Th17/Treg. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Nov; 120(?):155039. doi: 10.1016/j.phymed.2023.155039. [PMID: 37672855]
  • Tong-Juan Tang, Xiang Wang, Liang Wang, Ming Chen, Jing Cheng, Meng-Yu Zuo, Jin-Fan Gu, Rui Ding, Peng Zhou, Jin-Ling Huang. Liquiritin inhibits H2 O2 -induced oxidative stress injury in H9c2 cells via the AMPK/SIRT1/NF-κB signaling pathway. Journal of food biochemistry. 2022 10; 46(10):e14351. doi: 10.1111/jfbc.14351. [PMID: 35929638]
  • Junyuan Qin, Junren Chen, Fu Peng, Chen Sun, Yu Lei, Guangru Chen, Gangming Li, Yanpeng Yin, Ziwei Lin, Liujun Wu, Jing Li, Wenxiu Liu, Cheng Peng, Xiaofang Xie. Pharmacological activities and pharmacokinetics of liquiritin: A review. Journal of ethnopharmacology. 2022 Jul; 293(?):115257. doi: 10.1016/j.jep.2022.115257. [PMID: 35395381]
  • Quan Bi, Hua Yao, Fei Wang, Dajun He, Wenbin Xu, Shuangquan Xie, Xifeng Chen, Yuxia Li, Hailiang Liu, Haitao Shen, Hongbin Li. Integrative analysis of the pharmaceutical active ingredient and transcriptome of the aerial parts of Glycyrrhiza uralensis under salt stress reveals liquiritin accumulation via ABA-mediated signaling. Molecular genetics and genomics : MGG. 2022 Mar; 297(2):333-343. doi: 10.1007/s00438-021-01847-1. [PMID: 35187583]
  • Meina Gao, Hui Li, Chenghao Ye, Kaixian Chen, Hualiang Jiang, Kunqian Yu. Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico Study. Biomolecules. 2021 10; 11(11):. doi: 10.3390/biom11111586. [PMID: 34827585]
  • Yuanjie Li, Changbo Xia, Guangda Yao, Xia Zhang, Jianjun Zhao, Xiaojuan Gao, Jingjiao Yong, Hanqing Wang. Protective effects of liquiritin on UVB-induced skin damage in SD rats. International immunopharmacology. 2021 Aug; 97(?):107614. doi: 10.1016/j.intimp.2021.107614. [PMID: 33892299]
  • Shan Jiang, Shaoping Wang, Pingping Dong, Lei Shi, Qiyan Li, Xia Wei, Peng Gao, Jiayu Zhang. A comprehensive profiling and identification of liquiritin metabolites in rats using ultra-high-performance liquid chromatography coupled with linear ion trap-orbitrap mass spectrometer. Xenobiotica; the fate of foreign compounds in biological systems. 2021 May; 51(5):564-581. doi: 10.1080/00498254.2020.1854366. [PMID: 33222601]
  • Zibin Lu, Huihui Cao, Dongyi Liu, Yuanru Zheng, Chunyang Tian, Shanhong Liu, Jingyu Quan, Lingzhu Shi, Junshan Liu, Linzhong Yu. Optimal combination of anti-inflammatory components from Chinese medicinal formula Liang-Ge-San. Journal of ethnopharmacology. 2021 Apr; 269(?):113747. doi: 10.1016/j.jep.2020.113747. [PMID: 33359185]
  • Yahang Wang, Yuanyuan Li, Hua Zhang, Leilei Zhu, Jie Zhong, Jiakai Zeng, Cong Meng, Jiasheng Wu, Tianming Wang, Rong Shi, Weian Yuan, Jian Jiang, Ping Liu, Yueming Ma. Pharmacokinetics-based comprehensive strategy to identify multiple effective components in Huangqi decoction against liver fibrosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Apr; 84(?):153513. doi: 10.1016/j.phymed.2021.153513. [PMID: 33647776]
  • Jianwei Dou, Zhongbo Zhu, Yan Li, Shuo Yang, Zhanzi Guo, Kangle Li, Cuicui Ren, Linhong Huang, Jianyu He. Development and evaluation of poly adenosine 5'-diphosphate-ribose polymerase 1 immobilization-based receptor chromatography. Journal of separation science. 2021 Feb; 44(4):793-804. doi: 10.1002/jssc.202000856. [PMID: 33275824]
  • Wen Weng, Qilong Wang, Chunmei Wei, Michael Adu-Frimpong, Elmurat Toreniyazov, Hao Ji, Jiangnan Yu, Ximing Xu. Mixed micelles for enhanced oral bioavailability and hypolipidemic effect of liquiritin: preparation, in vitro and in vivo evaluation. Drug development and industrial pharmacy. 2021 Feb; 47(2):308-318. doi: 10.1080/03639045.2021.1879839. [PMID: 33494627]
  • Peiqing Liu, Yushan Cai, Jinzhu Zhang, Rongbo Wang, Benjin Li, Qiyong Weng, Qinghe Chen. Antifungal activity of liquiritin in Phytophthora capsici comprises not only membrane-damage-mediated autophagy, apoptosis, and Ca2+ reduction but also an induced defense responses in pepper. Ecotoxicology and environmental safety. 2021 Feb; 209(?):111813. doi: 10.1016/j.ecoenv.2020.111813. [PMID: 33360212]
  • Xiao Li, Xuemei Qin, Junsheng Tian, Xiaoxia Gao, Xingkang Wu, Guanhua Du, Yuzhi Zhou. Liquiritin protects PC12 cells from corticosterone-induced neurotoxicity via regulation of metabolic disorders, attenuation ERK1/2-NF-κB pathway, activation Nrf2-Keap1 pathway, and inhibition mitochondrial apoptosis pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Dec; 146(?):111801. doi: 10.1016/j.fct.2020.111801. [PMID: 33035630]
  • Tianyang Wang, Song Lin, Hua Li, Ran Liu, Zihan Liu, Huarong Xu, Qing Li, Kaishun Bi. A stepwise integrated multi-system to screen quality markers of Chinese classic prescription Qingzao Jiufei decoction on the treatment of acute lung injury by combining 'network pharmacology-metabolomics-PK/PD modeling'. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Nov; 78(?):153313. doi: 10.1016/j.phymed.2020.153313. [PMID: 32866904]
  • Zhi-Qiang Yan, Jing Tan, Kai Guo, Lun-Guang Yao. Phytotoxic mechanism of allelochemical liquiritin on root growth of lettuce seedlings. Plant signaling & behavior. 2020 Oct; 15(10):1795581. doi: 10.1080/15592324.2020.1795581. [PMID: 32693669]
  • Xin-Yi Lan, Hui Yu, Qiu-Jing Chen, Shuo Zhai, Chun-Feng Zhang, Fei Li, Chong-Zhi Wang, Chun-Su Yuan. Effect of liquiritin on neuroendocrine-immune network in menopausal rat model. Phytotherapy research : PTR. 2020 Oct; 34(10):2665-2674. doi: 10.1002/ptr.6696. [PMID: 32281178]
  • Hao Wang, Hu Shan, Haitao Lü. Preparative Separation and Purification of Liquiritin and Glycyrrhizic Acid from Glycyrrhiza uralensis Fisch by High-Speed Countercurrent Chromatography. Journal of chromatographic science. 2020 Sep; 58(9):823-830. doi: 10.1093/chromsci/bmaa050. [PMID: 32869089]
  • Hanli Dang, Tao Zhang, Guifang Li, Yudi Mu, Xinhua Lv, Zhongke Wang, Li Zhuang. Root-associated endophytic bacterial community composition and structure of three medicinal licorices and their changes with the growing year. BMC microbiology. 2020 09; 20(1):291. doi: 10.1186/s12866-020-01977-3. [PMID: 32957914]
  • Min Chen, Qiu-Ping Zhang, Ji-Xiao Zhu, Jie Cheng, Qing Liu, Guang-Hui Xu, Cheng-Fu Li, Li-Tao Yi. Involvement of FGF-2 modulation in the antidepressant-like effects of liquiritin in mice. European journal of pharmacology. 2020 Aug; 881(?):173297. doi: 10.1016/j.ejphar.2020.173297. [PMID: 32580037]
  • Lin Zhang, Chen-Xiang Wang, Jing Wu, Tian-Yun Wang, Qiao-Qiao Zhong, Yan Du, Shuai Ji, Liang Wang, Meng-Zhe Guo, Sheng-Qiu Xu, Dao-Quan Tang. Metabolic profiling of mice plasma, bile, urine and feces after oral administration of two licorice flavonones. Journal of ethnopharmacology. 2020 Jul; 257(?):112892. doi: 10.1016/j.jep.2020.112892. [PMID: 32320727]
  • Jina Yang, Wenbin Jin, Danyang Liu, Qisheng Zhong, Ting Zhou. Enhanced pseudotargeted analysis using a segment data dependent acquisition strategy by liquid chromatography-tandem mass spectrometry for a metabolomics study of liquiritin in the treatment of depression. Journal of separation science. 2020 Jun; 43(11):2088-2096. doi: 10.1002/jssc.202000107. [PMID: 32144949]
  • Pengcheng Huang, Yinghong Tang, Chang Li, Huifen Zhou, Li Yu, Haitong Wan, Yu He. Correlation study between the pharmacokinetics of seven main active ingredients of Mahuang decoction and its pharmacodynamics in asthmatic rats. Journal of pharmaceutical and biomedical analysis. 2020 May; 183(?):113144. doi: 10.1016/j.jpba.2020.113144. [PMID: 32070931]
  • Waheed Akram, Taiba Saeed, Aqeel Ahmad, Nasim A Yasin, Muhammad Akbar, Waheed U Khan, Shakeel Ahmed, Juxian Guo, Wenlong Luo, Tingquan Wu, Guihua Li. Liquiritin elicitation can increase the content of medicinally important glucosinolates and phenolic compounds in Chinese kale plants. Journal of the science of food and agriculture. 2020 Mar; 100(4):1616-1624. doi: 10.1002/jsfa.10170. [PMID: 31773731]
  • Qiuyan Guo, Koji Mizuno, Katsuki Okuyama, Na Lin, Yanqiong Zhang, Hideki Hayashi, Norio Takagi, Takashi Sato. Antineuropathic pain actions of Wu-tou decoction resulted from the increase of neurotrophic factor and decrease of CCR5 expression in primary rat glial cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Mar; 123(?):109812. doi: 10.1016/j.biopha.2020.109812. [PMID: 31945696]
  • Kang Uk Kim, Sung-Jin Lee, Inhyung Lee. Development of an Improved Menopausal Symptom-Alleviating Licorice (Glycyrrhiza uralensis) by Biotransformation Using Monascus albidulus. Journal of microbiology and biotechnology. 2020 Feb; 30(2):178-186. doi: 10.4014/jmb.1909.09037. [PMID: 31752065]
  • Jun Jiang, Shichang Xiao, Shu Yan, Jianpeng Xiao, Ximing Xu. Glycyrrhizae Radix et Rhizoma Processed by Sulfur Fumigation Damaged the Chemical Profile Accompanied by Immunosuppression and Liver Injury. BioMed research international. 2020; 2020(?):5439853. doi: 10.1155/2020/5439853. [PMID: 32090097]
  • Zhenlin Huang, Qing Zhao, Minwei Chen, Jingnan Zhang, Lili Ji. Liquiritigenin and liquiritin alleviated monocrotaline-induced hepatic sinusoidal obstruction syndrome via inhibiting HSP60-induced inflammatory injury. Toxicology. 2019 12; 428(?):152307. doi: 10.1016/j.tox.2019.152307. [PMID: 31589899]
  • Chengcheng Wang, Lihong Chen, Zhichen Cai, Cuihua Chen, Zixiu Liu, Xunhong Liu, Lisi Zou, Jiali Chen, Mengxia Tan, Lifang Wei, Yuqi Mei. Dynamic Variations in Multiple Bioactive Constituents under Salt Stress Provide Insight into Quality Formation of Licorice. Molecules (Basel, Switzerland). 2019 Oct; 24(20):. doi: 10.3390/molecules24203670. [PMID: 31614687]
  • Simiao Fan, Kun Gu, Yuanyuan Wu, Houmin Luo, Yuming Wang, Tianpu Zhang, Xing Wang, Yanjun Zhang, Yubo Li. Liquiritinapioside - A mineralocorticoid-like substance from liquorice. Food chemistry. 2019 Aug; 289(?):419-425. doi: 10.1016/j.foodchem.2019.03.056. [PMID: 30955632]
  • Minwei Chen, Chaochao Zhang, Jingnan Zhang, Guoyin Kai, Bin Lu, Zhenlin Huang, Lili Ji. The involvement of DAMPs-mediated inflammation in cyclophosphamide-induced liver injury and the protection of liquiritigenin and liquiritin. European journal of pharmacology. 2019 Aug; 856(?):172421. doi: 10.1016/j.ejphar.2019.172421. [PMID: 31136760]
  • Jun-Jin Liu, Yao Cheng, Yun-Yun Shao, Zhuang-Peng Chang, Yi-Ting Guo, Xiao-Juan Feng, Ding Xu, Jing-Ping Zhang, Yan Song, Rui-Gang Hou. Comparative pharmacokinetics and metabolites study of seven major bioactive components of Shaoyao-Gancao decoction in normal and polycystic ovary syndrome rats by ultra high pressure liquid chromatography with tandem mass spectrometry. Journal of separation science. 2019 Aug; 42(15):2534-2549. doi: 10.1002/jssc.201900002. [PMID: 31144455]
  • Zilingyun Wang, Rui An, Guangli Du, Kun Liang, Guowen Li. Validation of an LC-MS/MS method for simultaneous detection of diverse components of Qinxing Qingre Zhike Granule in rat plasma and its application to pharmacokinetic study after oral administration to rats. Biomedical chromatography : BMC. 2019 Jul; 33(7):e4524. doi: 10.1002/bmc.4524. [PMID: 30821835]
  • Huan Gao, Lishi Zhang, Jiannan Song, Dong Bai. Absorption and biotransformation of four compounds in the Guizhi decoction in the gastrointestinal tracts of rats. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2019 06; 39(3):332-338. doi: . [PMID: 32186005]
  • Zhao-Guang Zheng, You-Hua Xu, Fang Liu, Ting-Ting Zhao, Rui-Xue Wang, Pei-Ying Huang, Ru-Shang Wang, An-Ping Yang, Quan Zhu. Screening bioactive components of Glycyrrhiza uralensis Fisch. with isolated perfused lung extraction and HPLC-ESI-MSn analysis. Journal of pharmaceutical and biomedical analysis. 2019 May; 169(?):127-132. doi: 10.1016/j.jpba.2019.03.007. [PMID: 30861404]
  • You Jin Han, Bitna Kang, Eun-Ju Yang, Min-Koo Choi, Im-Sook Song. Simultaneous Determination and Pharmacokinetic Characterization of Glycyrrhizin, Isoliquiritigenin, Liquiritigenin, and Liquiritin in Rat Plasma Following Oral Administration of Glycyrrhizae Radix Extract. Molecules (Basel, Switzerland). 2019 May; 24(9):. doi: 10.3390/molecules24091816. [PMID: 31083444]
  • Zhenlin Huang, Yuchen Sheng, Minwei Chen, Zhanxia Hao, Feifei Hu, Lili Ji. Liquiritigenin and liquiritin alleviated MCT-induced HSOS by activating Nrf2 antioxidative defense system. Toxicology and applied pharmacology. 2018 09; 355(?):18-27. doi: 10.1016/j.taap.2018.06.014. [PMID: 29908794]
  • Xinwen Lv, Yongbing Zhang, Hujin Zhang. Neuroprotective effect of Trichosanthes kirilowii cassia twig on cerebral ischemia-reperfusion injury in rats. Pakistan journal of pharmaceutical sciences. 2018 Jul; 31(4(Special)):1643-1647. doi: . [PMID: 30203753]
  • Yuwei Zhu, Xiaoyi Chen, Shumei Wang, Shengwang Liang, Chao Chen. Simultaneous measurement of contents of liquirtin and glycyrrhizic acid in liquorice based on near infrared spectroscopy. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2018 May; 196(?):209-214. doi: 10.1016/j.saa.2018.02.021. [PMID: 29453095]
  • Wei Xie, Zhipeng Hao, Xiaofu Zhou, Xuelian Jiang, Lijiao Xu, Songlin Wu, Aihua Zhao, Xin Zhang, Baodong Chen. Arbuscular mycorrhiza facilitates the accumulation of glycyrrhizin and liquiritin in Glycyrrhiza uralensis under drought stress. Mycorrhiza. 2018 Apr; 28(3):285-300. doi: 10.1007/s00572-018-0827-y. [PMID: 29455337]
  • Rui Yang, Wendong Li, Bochuan Yuan, Guangxi Ren, Liqiang Wang, Ting Cheng, Ying Liu. The genetic and chemical diversity in three original plants of licorice, Glycyrriza uralensis Fisch., Glycyrrhiza inflata Bat. and Glycyrrhiza glabra L. Pakistan journal of pharmaceutical sciences. 2018 Mar; 31(2):525-535. doi: . [PMID: 29618444]
  • Lin Zhang, Huiying Xu, Libin Zhan. Pharmacokinetic Assessments of Liquiritin, Protocatechuic Aldehyde and Rosmarinic Acid in Rat Plasma by UPLC-MS-MS After Administration of ZibuPiyin Recipe. Journal of chromatographic science. 2018 Feb; 56(2):139-146. doi: 10.1093/chromsci/bmx093. [PMID: 29186346]
  • Min Zhang, Yang Deng, Chao Wang, Hua-Lin Cai, Jing Wen, Ping-Fei Fang, Bi-Kui Zhang, Huan-De Li, Miao Yan. An LC-MS/MS method for determination of bioactive components of liquorice and Semen Strychni in rat plasma: Application to a pharmacokinetics study. Drug testing and analysis. 2018 Feb; 10(2):262-271. doi: 10.1002/dta.2210. [PMID: 28447397]
  • Sen Sun, Qingshan Chen, Jiyun Ge, Xiang Liu, Xinxia Wang, Qi Zhan, Hai Zhang, Guoqing Zhang. Pharmacokinetic interaction of aconitine, liquiritin and 6-gingerol in a traditional Chinese herbal formula, Sini Decoction. Xenobiotica; the fate of foreign compounds in biological systems. 2018 Jan; 48(1):45-52. doi: 10.1080/00498254.2017.1278807. [PMID: 28051355]
  • Yi Kuang, Bin Li, Jingran Fan, Xue Qiao, Min Ye. Antitussive and expectorant activities of licorice and its major compounds. Bioorganic & medicinal chemistry. 2018 01; 26(1):278-284. doi: 10.1016/j.bmc.2017.11.046. [PMID: 29224994]
  • Jing Qiao, Zuliang Luo, Yanpeng Li, Guangxi Ren, Chunsheng Liu, Xiaojun Ma. Effect of Abscisic Acid on Accumulation of Five Active Components in Root of Glycyrrhiza uralensis. Molecules (Basel, Switzerland). 2017 Nov; 22(11):. doi: 10.3390/molecules22111982. [PMID: 29140310]
  • Feng Wei, Xin Jiang, Hao-Yue Gao, Shuo-Hui Gao. Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo. International journal of oncology. 2017 Nov; 51(5):1383-1394. doi: 10.3892/ijo.2017.4134. [PMID: 29048624]
  • Xian-Fei Zhang, Jun-Li Yang, Juan Chen, Yan-Ping Shi. Optimization of a Decoction Process for an Herbal Formula Using a Response Surface Methodology. Journal of AOAC International. 2017 Nov; 100(6):1776-1784. doi: 10.5740/jaoacint.17-0022. [PMID: 28534469]
  • Jinglong Wang, Dandan Zheng, Yingzi Wang, Chao Zhang, Xiumei Sun. Pharmacokinetics study of Erhuang decoction extracts in rats by HPLC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Aug; 1059(?):35-42. doi: 10.1016/j.jchromb.2017.05.019. [PMID: 28570935]
  • Zhe Deng, Meng-Jiao Jiao, Jun Zhang, Jing Xian, Qing Zhang, Chang Chen, Yue-Sheng Wang, An Liu. [Application of relative quality constant in grades evaluation of Glycyrrizae Radix et Rhizome pieces]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 Jul; 42(13):2492-2496. doi: 10.19540/j.cnki.cjcmm.20170503.002. [PMID: 28840689]
  • Yinghong Tang, Mengkai Zheng, Yu-Lin Chen, Jianzhen Chen, Yu He. Pharmacokinetic Effects of Cinnamic Acid, Amygdalin, Glycyrrhizic Acid and Liquiritin on Ephedra Alkaloids in Rats. European journal of drug metabolism and pharmacokinetics. 2017 Jun; 42(3):527-535. doi: 10.1007/s13318-016-0368-8. [PMID: 27514823]
  • Zehua Li, Haiyang Gao, Jiangying Li, Yajun Zhang. Identification of bioactive compounds in Shaoyao-Gancao decoction using β2-adrenoceptor affinity chromatography. Journal of separation science. 2017 Jun; 40(12):2558-2564. doi: 10.1002/jssc.201700113. [PMID: 28432819]
  • Yuanyi Wei, Lei La, Lili Wang, Robert Batey, Chunxia Wang, Yuhao Li. Paeoniflorin and liquiritin, two major constituents in Chinese herbal formulas used to treat hyperprolactinemia-associated disorders, inhibits prolactin secretion in prolactinoma cells by different mechanisms. Journal of ethnopharmacology. 2017 May; 204(?):36-44. doi: 10.1016/j.jep.2017.03.054. [PMID: 28396166]
  • Wen-Jun Qu, Hui-Fang Li, Yuan-Yuan Su, Zheng-Qi Dong, Yan-Ru Ge. [Absorption enhancing effects and safety of PAMAM dendrimers on liquiritin]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 May; 42(9):1766-1771. doi: 10.19540/j.cnki.cjcmm.2017.0070. [PMID: 29082704]
  • Wei-Xiong Lin, Zhi-Yong Le, Hai-Yan Che, Yin-Zhen Liu, Chong Liu, Hui Wang. [Research on Glycyrrhizeae Radix standard decoction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 Mar; 42(5):830-835. doi: 10.19540/j.cnki.cjcmm.20161222.070. [PMID: 28994521]
  • Rui Yang, Wen-dong Li, Yong-sheng Ma, Shan Zhou, Yu-tao Xue, Rui-chao Lin, Ying Liu. [The molecular identification of licorice species and the quality evaluation of licorice slices]. Yao xue xue bao = Acta pharmaceutica Sinica. 2017 Feb; 52(2):318-26. doi: . [PMID: 29979533]
  • Yuyan Zhang, Li Yu, Weifeng Jin, Hongjing Fan, Min Li, Tianmei Zhou, Haitong Wan, Jiehong Yang. REDUCING TOXICITY AND INCREASING EFFICIENCY: ACONITINE WITH LIQUIRITIN AND GLYCYRRHETINIC ACID REGULATE CALCIUM REGULATORY PROTEINS IN RAT MYOCARDIAL CELL. African journal of traditional, complementary, and alternative medicines : AJTCAM. 2017; 14(4):69-79. doi: 10.21010/ajtcam.v14i4.9. [PMID: 28638869]
  • Shunsuke Fujii, Osamu Morinaga, Takuhiro Uto, Shuichi Nomura, Yukihiro Shoyama. Simultaneous determination of glycyrrhizin and liquiritin in licorice roots and Kampo medicines by combination enzyme-linked immunosorbent assay using anti-glycyrrhizin and anti-liquiritin monoclonal antibodies. Journal of immunoassay & immunochemistry. 2017; 38(3):285-298. doi: 10.1080/15321819.2016.1260586. [PMID: 27892811]
  • Yuan Zhang, Lei Zhang, Yi Zhang, Jin-Jin Xu, Li-Li Sun, Shuang-Zhan Li. The protective role of liquiritin in high fructose-induced myocardial fibrosis via inhibiting NF-κB and MAPK signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 Dec; 84(?):1337-1349. doi: 10.1016/j.biopha.2016.10.036. [PMID: 27810791]
  • Shunsuke Fujii, Osamu Morinaga, Takuhiro Uto, Shuichi Nomura, Yukihiro Shoyama. Development of Double Eastern Blotting for Major Licorice Components, Glycyrrhizin and Liquiritin for Chemical Quality Control of Licorice Using anti-Glycyrrhizin and anti-Liquiritin Monoclonal Antibodies. Journal of agricultural and food chemistry. 2016 Feb; 64(5):1087-93. doi: 10.1021/acs.jafc.5b04732. [PMID: 26765784]
  • Yun Luo, Guo-Wei Zhao, Xin-Li Liang, Jing Zhang, Xiao-Fei Zhang, Qin Zheng, Ming Yang, Zheng-Gen Liao. [Changes of specific chromatograms and contents of five components in Yinqiao powder decoctions during decocting process]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Jan; 41(1):60-64. doi: 10.4268/cjcmm20160112. [PMID: 28845641]
  • Jing Qiao, Jun Hu, Yan-Peng Li, Guang-Xi Ren, Yu Xiang, Yi-Mei Zang, Yong Liu, Chun-Sheng Liu. [Effect of exogenous brassinolide on morphological characters and contents of seven chemical constituents of Glycyrrhiza uralensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Jan; 41(2):197-204. doi: 10.4268/cjcmm20160208. [PMID: 28861963]
  • Yao Gao, Li Gao, Xiao-xia Gao, Yu-zhi Zhou, Xue-mei Qin, Jun-sheng Tian. [An exploration in the action targets for antidepressant bioactive components of Xiaoyaosan based on network pharmacology]. Yao xue xue bao = Acta pharmaceutica Sinica. 2015 Dec; 50(12):1589-95. doi: . [PMID: 27169281]
  • Xue-yan Zhan, Zhao-zhou Lin, Yang Sun, Rui-juan Yuan, Zhan-lan Yang, Tian-xuan Duan. [Feature Selection and Interpretation in Infrared Quantitative Models of Liquiritin and Glycyrrhizin in Radix Glycyrrhizae]. Guang pu xue yu guang pu fen xi = Guang pu. 2015 Sep; 35(9):2530-5. doi: . [PMID: 26669161]
  • Ji-Yeon Yu, Jae Yeo Ha, Kyung-Mi Kim, Young-Suk Jung, Jae-Chul Jung, Seikwan Oh. Anti-Inflammatory activities of licorice extract and its active compounds, glycyrrhizic acid, liquiritin and liquiritigenin, in BV2 cells and mice liver. Molecules (Basel, Switzerland). 2015 Jul; 20(7):13041-54. doi: 10.3390/molecules200713041. [PMID: 26205049]
  • Weijun Kong, Yanling Zhao, Xiaoyan Xing, Xinping Ma, Xiaojiao Sun, Meihua Yang, Xiaohe Xiao. Antibacterial evaluation of flavonoid compounds against E. coli by microcalorimetry and chemometrics. Applied microbiology and biotechnology. 2015 Jul; 99(14):6049-58. doi: 10.1007/s00253-015-6711-1. [PMID: 26051672]
  • Yang Zhang, Dawei Qian, Ying Pan, Zhenghua Zhu, Jing Huang, Junzuan Xi, Jianming Guo, Xueping Zhou, Gansheng Zhong, Jinao Duan. Comparisons of the pharmacokinetic profile of four bioactive components after oral administration of gan-sui-ban-xia decoction plus-minus gansui and gancao drug combination in normal rats. Molecules (Basel, Switzerland). 2015 May; 20(5):9295-308. doi: 10.3390/molecules20059295. [PMID: 26007184]
  • Yu Xiang, Chun-sheng Liu, Yong Liu, Xiao-na Song, Xuan Gu. [Effects of abscisic acid on chemical components content and color of Glycyrrhiza uralensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 May; 40(9):1688-92. doi: ". [PMID: 26323130]
  • Hui Gong, Bi-kui Zhang, Miao Yan, Ping-fei Fang, Huan-de Li, Chun-ping Hu, Yang Yang, Peng Cao, Pei Jiang, Xin-rong Fan. A protective mechanism of licorice (Glycyrrhiza uralensis): isoliquiritigenin stimulates detoxification system via Nrf2 activation. Journal of ethnopharmacology. 2015 Mar; 162(?):134-9. doi: 10.1016/j.jep.2014.12.043. [PMID: 25557030]
  • Jia Hou, Li-ben Yan, Gui-liang Zhao, Tao Du, Shi-jun Shao. [Relationship Between Seedling Grade of Glycyrrhiza uralensis and Plant Biomass Accumulation, Yield and Quality of Product]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Feb; 38(2):221-6. doi: ". [PMID: 26415393]
  • S J Kim, S S Kwon, S H Jeon, E R Yu, S N Park. Enhanced skin delivery of liquiritigenin and liquiritin-loaded liposome-in-hydrogel complex system. International journal of cosmetic science. 2014 Dec; 36(6):553-60. doi: 10.1111/ics.12156. [PMID: 25074560]
  • Thi Thanh Hanh Nguyen, Seung-Jin Jung, Hee-Kyoung Kang, Young-Min Kim, Young-Hwan Moon, Misook Kim, Doman Kim. Production of rubusoside from stevioside by using a thermostable lactase from Thermus thermophilus and solubility enhancement of liquiritin and teniposide. Enzyme and microbial technology. 2014 Oct; 64-65(?):38-43. doi: 10.1016/j.enzmictec.2014.07.001. [PMID: 25152415]
  • Chang-Li Liu, Yan Yin, Shu-Hua Zhang, Qian Li, Min Chen, Xu Guo. [Study on correlation between trace elements and active ingredient in glycyrrhizae radix et rhizome]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 Sep; 39(17):3335-8. doi: NULL. [PMID: 25522623]
  • Wei Zhang, Shu Jiang, Dawei Qian, Er-xin Shang, Jin-ao Duan. Effect of liquiritin on human intestinal bacteria growth: metabolism and modulation. Biomedical chromatography : BMC. 2014 Sep; 28(9):1271-7. doi: 10.1002/bmc.3160. [PMID: 24616071]
  • Charlotte Simmler, Dejan Nikolić, David C Lankin, Yang Yu, J Brent Friesen, Richard B van Breemen, Alicia Lecomte, Céline Le Quémener, Grégoire Audo, Guido F Pauli. Orthogonal Analysis Underscores the Relevance of Primary and Secondary Metabolites in Licorice. Journal of natural products. 2014 Aug; 77(8):1806-16. doi: 10.1021/np5001945. [PMID: 25080313]
  • Wen Zhang, Liu-qing Di, Jun-Song Li, Jin-jun Shan, An Kang, Shuai Qian, Le-tian Chen. The effects of Glycyrrhizae uralenis and its major bioactive components on pharmacokinetics of daphnetin in Cortex daphnes in rats. Journal of ethnopharmacology. 2014 Jul; 154(3):584-92. doi: 10.1016/j.jep.2014.03.047. [PMID: 24704595]
  • Yan Yan, Cheng-Zhi Chai, Da-Wei Wang, Jie Wu, Hong-He Xiao, Li-Xia Huo, Dan-Ni Zhu, Bo-Yang Yu. Simultaneous determination of puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma and its application to a pharmacokinetic study of Ge-Gen Decoction by a liquid chromatography-electrospray ionization-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2014 Jul; 95(?):76-84. doi: 10.1016/j.jpba.2014.02.013. [PMID: 24637051]
  • Chang-Seob Seo, Jung Hoon Kim, Hyeun-Kyoo Shin. Simultaneous determination of liquiritin, nodakenin and glycyrrhizinin Guibi-tang, a traditional herbal prescription by HPLC-PDA. Pakistan journal of pharmaceutical sciences. 2014 Jul; 27(4):819-24. doi: . [PMID: 25015446]
  • Ling Ding, Hong-Yi Li, Xue-Wen Zhang. [Quantitative estimation of glycyrrhizic acid and liquiritin contents using in-situ canopy spectroscopy]. Guang pu xue yu guang pu fen xi = Guang pu. 2014 Jul; 34(7):1933-7. doi: ". [PMID: 25269311]
  • Yi Dong, Mouming Zhao, Tiantian Zhao, Mengying Feng, Huiping Chen, Mingzhu Zhuang, Lianzhu Lin. Bioactive profiles, antioxidant activities, nitrite scavenging capacities and protective effects on H2O2-injured PC12 cells of Glycyrrhiza glabra L. leaf and root extracts. Molecules (Basel, Switzerland). 2014 Jun; 19(7):9101-13. doi: 10.3390/molecules19079101. [PMID: 24983860]
  • Ulrike Grienke, Heike Braun, Nora Seidel, Johannes Kirchmair, Martina Richter, Andi Krumbholz, Susanne von Grafenstein, Klaus R Liedl, Michaela Schmidtke, Judith M Rollinger. Computer-guided approach to access the anti-influenza activity of licorice constituents. Journal of natural products. 2014 Mar; 77(3):563-70. doi: 10.1021/np400817j. [PMID: 24313801]
  • Chang-Seob Seo, Ohn Soon Kim, Yeji Kim, Hyeun-Kyoo Shin. Simultaneous quantification and inhibitory effect on LDL oxidation of the traditional Korean medicine, Leejung-tang. BMC complementary and alternative medicine. 2014 Jan; 14(?):3. doi: 10.1186/1472-6882-14-3. [PMID: 24383717]
  • Yanling Zhou, Wing Shing Ho. Combination of liquiritin, isoliquiritin and isoliquirigenin induce apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells. Oncology reports. 2014 Jan; 31(1):298-304. doi: 10.3892/or.2013.2849. [PMID: 24247527]
  • Zheng-zheng Guo, Yan-long Wu, Ru-feng Wang, Wen-quan Wang, Ying Liu, Xiao-qin Zhang, Shu-rui Gao, Yuan Zhang, Sheng-li Wei. Distribution patterns of the contents of five active components in taproot and stolon of Glycyrrhiza uralensis. Biological & pharmaceutical bulletin. 2014; 37(7):1253-8. doi: 10.1248/bpb.b14-00173. [PMID: 24805208]
  • Yi-Zhu Zhang, Rui An, Jin Yuan, Yue Wang, Qing-Qing Gu, Xin-Hong Wang. [Analysis and comparison of intestinal absorption of components of Gegenqinlian decoction in different combinations based on pharmacokinetic parameters]. Yao xue xue bao = Acta pharmaceutica Sinica. 2013 Oct; 48(10):1611-7. doi: . [PMID: 24417090]
  • Karoline Peter, Johann Schinnerl, Susanne Felsinger, Lothar Brecker, Rudolf Bauer, Heimo Breiteneder, Riurong Xu, Yan Ma. A novel concept for detoxification: complexation between aconitine and liquiritin in a Chinese herbal formula ('Sini Tang'). Journal of ethnopharmacology. 2013 Sep; 149(2):562-9. doi: 10.1016/j.jep.2013.07.022. [PMID: 23892202]
  • Xiao-Xia Gao, Jie Cui, Xing-Yu Zheng, Zhen-Yu Li, Young-Hae Choi, Yu-Zhi Zhou, Jun-Sheng Tian, Jie Xing, Xiao-Jie Tan, Guan-Hua Du, Xue-Mei Qin. An investigation of the antidepressant action of xiaoyaosan in rats using ultra performance liquid chromatography-mass spectrometry combined with metabonomics. Phytotherapy research : PTR. 2013 Jul; 27(7):1074-85. doi: 10.1002/ptr.4805. [PMID: 22975930]
  • Lei Yang, Li-li Li, Ting-ting Liu, Yuan-gang Zu, Feng-jian Yang, Chun-jian Zhao, Lin Zhang, Xiao-qiang Chen, Zhong-hua Zhang. Development of sample preparation method for isoliquiritigenin, liquiritin, and glycyrrhizic acid analysis in licorice by ionic liquids-ultrasound based extraction and high-performance liquid chromatography detection. Food chemistry. 2013 May; 138(1):173-9. doi: 10.1016/j.foodchem.2012.10.059. [PMID: 23265473]
  • Keiko K Lee, Yuji Omiya, Mitsutoshi Yuzurihara, Yoshio Kase, Hiroyuki Kobayashi. Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix. Journal of ethnopharmacology. 2013 Jan; 145(1):286-93. doi: 10.1016/j.jep.2012.11.005. [PMID: 23164761]
  • Yin-Ping Wu, Xian-Sheng Meng, Yong-Rui Bao, Shuai Wang, Ting-Guo Kang. Simultaneous quantitative determination of nine active chemical compositions in traditional Chinese medicine Glycyrrhiza by RP-HPLC with full-time five-wavelength fusion method. The American journal of Chinese medicine. 2013; 41(1):211-9. doi: 10.1142/s0192415x13500158. [PMID: 23336517]
  • Yan Chen, Jinyan Wang, Lu Wang, Lianghui Chen, Qingqing Wu. Absorption and interaction of the main constituents from the traditional Chinese drug pair Shaoyao-Gancao via a Caco-2 cell monolayer model. Molecules (Basel, Switzerland). 2012 Dec; 17(12):14908-17. doi: 10.3390/molecules171214908. [PMID: 23519262]
  • Rui An, Hua Zhang, Yi-Zhu Zhang, Ran-Chi Xu, Xin-Hong Wang. [Intestinal absorption of different combinations of active compounds from Gegenqinlian decoction by rat single pass intestinal perfusion in situ]. Yao xue xue bao = Acta pharmaceutica Sinica. 2012 Dec; 47(12):1696-702. doi: ". [PMID: 23460978]
  • Xiaoyun Shu, Yuping Tang, Chenxue Jiang, Erxing Shang, Xinshen Fan, Anwei Ding. Comparative analysis of the main bioactive components of San-ao decoction and its series of formulations. Molecules (Basel, Switzerland). 2012 Nov; 17(11):12925-37. doi: 10.3390/molecules171112925. [PMID: 23117432]
  • Mingjing Yi, Wei Peng, Xiaomin Chen, Junjun Wang, Yong Chen. Effect of hypaconitine combined with liquiritin on the expression of calmodulin and connexin43 in rat cardiac muscle in vivo. The Journal of pharmacy and pharmacology. 2012 Nov; 64(11):1654-8. doi: 10.1111/j.2042-7158.2012.01532.x. [PMID: 23058053]
  • Bo-sha Zhang, Rui An, Yue Wang, Xin-hong Wang. [Cellular absorption of the active ingredients in different compatibilities of gegenqinlian decoction in human intestinal Caco-2 cells]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 Sep; 35(9):1460-3. doi: ". [PMID: 23451503]
  • Qing-Qing Wu, Yan Chen, Ran Xin, Jin-Yan Wang, Lei Zhou, Ling Yuan, Xiao-Bin Jia. [Multiple analysis of the difference in intestinal absorption between the main components and the extract of Glycyrrhiza uralensis]. Yao xue xue bao = Acta pharmaceutica Sinica. 2012 May; 47(5):657-63. doi: NULL. [PMID: 22812013]
  • Huai-Bin Zhao, Yan-Long Hong, You-Jie Wang, Lan Shen, Fei Wu, Yi Feng, Ke-Feng Ruan. [Influence of combination on the specific chromatogram of Glycyrrhiza in sini decoctions by HPLC]. Yao xue xue bao = Acta pharmaceutica Sinica. 2012 Apr; 47(4):508-11. doi: ". [PMID: 22799035]
  • Xiao Liu, Linqian Fan, Hao Cai, Baochang Cai. [Simultaneous determination of four components in sini tang by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Mar; 37(6):803-5. doi: . [PMID: 22715726]