Isokaempferide (BioDeep_00000407050)

natural product PANOMIX_OTCML-2023

代谢物信息卡片

5,7,4-trihydroxy-3-methoxyflavone

化学式: C16H12O6 (300.06338519999997)
中文名称: 异山柰素
谱图信息: 最多检出来源 Viridiplantae(plant) 4.94%

分子结构信息

SMILES: C1(O)=CC2OC(C3C=CC(O)=CC=3)=C(OC)C(=O)C=2C(O)=C1
InChI: InChI=1S/C16H12O6/c1-21-16-14(20)13-11(19)6-10(18)7-12(13)22-15(16)8-2-4-9(17)5-3-8/h2-7,17-19H,1H3

描述信息

同义名列表

3 个代谢物同义名

Isokaempferide; 5,7,4-trihydroxy-3-methoxyflavone; Kaempferol 3-methyl ether

数据库引用编号

25 个数据库交叉引用编号

ChEBI: CHEBI:1579
KEGG: C05902
PubChem: 5280862
ChEMBL: CHEMBL165064
LipidMAPS: LMPK12112688
CAS: 1592-70-7
MoNA: VF-NPL-QTOF008094
MoNA: VF-NPL-QTOF008093
MoNA: VF-NPL-QTOF008092
MoNA: VF-NPL-QTOF008091
MoNA: VF-NPL-QTOF008090
MoNA: VF-NPL-QTOF008089
MoNA: VF-NPL-LTQ003816
MoNA: VF-NPL-LTQ003814
MoNA: VF-NPL-LTQ003813
MoNA: VF-NPL-QEHF014172
MoNA: VF-NPL-QEHF014171
MoNA: VF-NPL-QEHF014170
MoNA: VF-NPL-QEHF014169
MoNA: VF-NPL-QEHF014168
MoNA: VF-NPL-QEHF014167
PubChem: 8190
KNApSAcK: C00001062
3DMET: B00873
NIKKAJI: J94.493I

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

136 个相关的物种来源信息

63345 - Achlys triphylla: 10.1016/0031-9422(91)83058-S
746491 - Achyrocline alata: 10.1016/0305-1978(93)90051-R
1744987 - Acritopappus heterolepis: 10.1016/S0031-9422(00)83946-1
4243 - Adenothamnus validus: 10.1016/0031-9422(88)87035-3
111156 - Aeonium canariense var. palmense: 10.1016/0031-9422(93)00074-P
111153 - Aeonium lindleyi: 10.1016/0031-9422(93)00074-P
35958 - Aeonium lindleyi var. viscatum: 10.1016/0031-9422(93)00074-P
111158 - Aeonium saundersii: 10.1016/0031-9422(93)00074-P
230216 - Agnorhiza bolanderi:
2770829 - Aldama gardneri: 10.1016/S0031-9422(02)00197-8
543563 - Alkanna orientalis: 10.1055/S-2006-957713
557622 - Allagopappus canariensis: 10.1021/NP50117A014
56513 - Allagopappus dichotomus: 10.1021/NP50117A014
557623 - Allagopappus viscosissimus: 10.1016/0031-9422(91)83067-U
3517 - Alnus glutinosa:
125268 - Alpinia tonkinensis: 10.1080/10286020310001653291
97723 - Alpinia zerumbet: 10.1016/J.BMC.2009.07.041
149628 - Amburana cearensis:
99027 - Anthemis: 10.1515/ZNC-2003-9-1014
7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
387567 - Aristolochia acutifolia: 10.1016/S0305-1978(01)00139-9
35608 - Artemisia annua:
262982 - Artemisia apiacea:
205362 - Artemisia austriaca: 10.1515/ZNC-1995-5-604
496566 - Artemisia carvifolia:
1227629 - Artemisia lindleyana: 10.1021/NP50043A027
86312 - Artemisia ludoviciana: 10.1016/0031-9422(82)80045-9
2707510 - Baccharis pseudovaccinioides: 10.1515/ZNC-1986-1-214
2603409 - Baccharis sarothroides: 10.1515/ZNC-1986-1-214
3508 - Betula nigra:
281167 - Brachyglottis cassinioides: 10.1016/0305-1978(93)90084-5
258520 - Calceolaria arachnoidea: 10.1515/ZNC-2000-1-203
240931 - Calceolaria chelidonioides:
240996 - Calceolaria tripartita:
390497 - Caragana leucophloea: 10.1080/14786419.2015.1007974
53852 - Cassia fistula: 10.21608/BFSA.1985.75705
508996 - Cassia javanica:
363412 - Centaurea alexandrina: 10.1055/S-2007-969314
1486496 - Centaurea arenaria: 10.1002/PTR.3187
1033235 - Centaurea bracteata:
41516 - Centaurea clementei:
1048535 - Centaurea cuneifolia: 10.1055/S-2007-971441
41526 - Centaurea dealbata: 10.1016/0031-9422(91)83195-Q
1486531 - Centaurea inermis: 10.1021/NP50035A034
910632 - Centaurea phrygia: 10.1016/0031-9422(91)85119-K
124936 - Centaurea virgata: 10.1021/NP50035A034
304121 - Chamaesaracha sordida: 10.1016/0305-1978(95)00017-O
65003 - Cheirolophus uliginosus: 10.1016/S0031-9422(00)89537-0
557631 - Chiliadenus candicans: 10.1016/S0031-9422(00)90542-9
1548556 - Chiliadenus iphionoides:
217578 - Chrysothamnus humilis: 10.1016/S0031-9422(99)00110-7
297476 - Cirsium oleraceum: 10.1007/BF00569015
566271 - Cistus albanicus: 10.1055/S-2007-969315
335163 - Cistus albidus: 10.1515/ZNC-1984-3-418
191224 - Cistus creticus:
2604101 - Cistus inflatus: 10.1515/ZNC-1984-3-418
335173 - Cistus ladanifer:
335179 - Cistus laurifolius:
335184 - Cistus monspeliensis: 10.1515/ZNC-1984-3-418
335164 - Cistus parviflorus: 10.1055/S-2007-969315
335172 - Cistus psilosepalus: 10.1515/ZNC-1984-3-418
335183 - Cistus sintenisii: 10.1055/S-2007-969315
1077932 - Cleome amblyocarpa:
890033 - Crotalaria madurensis: 10.1021/NP50034A003
912355 - Croton glabellus: 10.1139/V06-164
212293 - Croton insularis: 10.1002/HLCA.200590206
1532790 - Dittrichia graveolens: 10.1016/0031-9422(91)83034-I
151065 - Dodonaea viscosa:
191183 - Encelia ravenii: 10.1055/S-2006-962543
372415 - Encelia virginensis: 10.1055/S-2006-962543
1548342 - Eremanthus glomerulatus: 10.1016/S0031-9422(00)98542-X
1569402 - Eremanthus mollis: 10.1016/S0031-9422(00)98542-X
217966 - Ericameria laricifolia: 10.1515/ZNC-1984-11-1233
188299 - Erythranthe cardinalis: 10.1515/ZNC-2000-1-203
69919 - Erythranthe lewisii: 10.1016/0305-1978(92)90015-6
13533 - Fouquieria splendens: 10.1515/ZNC-1994-9-1022
224686 - Gahnia sieberiana: 10.1016/S0031-9422(00)84889-X
1623629 - Gardenia urvillei: 10.1016/J.EJMECH.2015.01.012
123905 - Genista ephedroides: 10.1021/NP980112S
28963 - Geranium macrorrhizum: 10.1016/S0040-4039(00)93123-X
46347 - Glycyrrhiza: 10.1248/CPB.37.3005
74613 - Glycyrrhiza uralensis:
662482 - Grindelia camporum: 10.1515/ZNC-1994-5-618
1114741 - Grindelia hirsutula: 10.1515/ZNC-1994-5-618
1114766 - Grindelia tarapacana: 10.1515/ZNC-1993-5-623
983334 - Gymnocarpium robertianum: 10.1016/S0031-9422(97)01003-0
147773 - Haplopappus foliosus: 10.1002/JLAC.198519851215
425879 - Holocarpha heermannii: 10.1016/0305-1978(94)90092-2
149430 - Holocarpha virgata: 10.1016/0305-1978(94)90092-2
147779 - Isocoma acradenia: 10.1016/0305-1978(90)90049-L
108398 - Larrea cuneifolia: 10.1016/S0031-9422(00)86519-X
66636 - Larrea tridentata: 10.1016/J.PHYTOCHEM.2004.07.009
1441044 - Lomatia dentata: 10.1016/0031-9422(73)80563-1
3879 - Medicago sativa: 10.1515/ZNC-1980-5-605
1424733 - Mirabilis viscosa: 10.1016/S0305-1978(96)00081-6
45164 - Muntingia calabura: 10.1016/S0031-9422(03)00112-2
414630 - Notholaena standleyi:
1616377 - Nymphaea nouchali var. caerulea: 10.5586/ASBP.1991.011
1005697 - Odontites viscosus: 10.1515/ZNC-2000-1-203
253082 - Pelargonium quercifolium: 10.1016/S0031-9422(97)00514-1
451078 - Pentagramma triangularis: 10.1016/S0031-9422(00)90665-4
176562 - Perityle emoryi: 10.1016/0305-1978(88)90007-5
2784706 - Perityle fosteri: 10.1016/0305-1978(88)90007-5
2784684 - Perityle lemmonii: 10.1016/0305-1978(88)90007-5
2784726 - Perityle vaseyi:
2896287 - Piptocoma antillana: 10.1016/J.TET.2012.01.061
883860 - Plagius maghrebinus: 10.1007/S10600-011-9844-1
1548633 - Pluchea odorata: 10.1515/ZNC-1985-5-607
2650213 - Polanisia trachysperma: 10.1016/0031-9422(89)85071-X
487757 - Polygonum cognatum: 10.1016/0031-9422(90)85309-4
688333 - Populus cathayana: 10.1515/ZNC-1992-3-423
3696 - Populus deltoides: 10.1515/ZNC-1990-0604
179740 - Populus szechuanica: 10.1515/ZNC-1992-3-423
3693 - Populus tremuloides: 10.1139/B91-288
13230 - Prosopis juliflora: 10.1016/0305-1978(78)90036-4
1138119 - Pseudodictamnus hirsutus: 10.1021/NP50045A043
1225829 - Psiadia dentata: 10.1177/095632020101200503
1077900 - Psiadia viscosa:
119188 - Pulicaria incisa:
75085 - Rubus phoenicolasius: 10.1515/ZNC-1993-11-1221
49211 - Salvia glutinosa: 10.1016/S0031-9422(01)00415-0
1933769 - Salvia yosgadensis:
41644 - Santolina chamaecyparissus: 10.1016/S0031-9422(97)00891-1
1142031 - Santolina villosa: 10.1016/S0031-9422(97)00891-1
85882 - Senecio viscosus: 10.1515/ZNC-1997-3-401
72401 - Senna didymobotrya: 10.21608/BFSA.1985.75705
346999 - Senna siamea: 10.21608/BFSA.1985.75705
310241 - Stylidocleome brachycarpa:
1522775 - Thulinella chrysantha:
207928 - Triantha glutinosa: 10.1016/0305-1978(94)90035-3
519526 - Vachellia vernicosa: 10.1016/S0031-9422(00)82416-4
54477 - Vitex agnus-castus: 10.1016/J.FITOTE.2010.12.003
4263 - Wilkesia gymnoxiphium: 10.1016/0031-9422(90)85423-D
71103 - Xanthocephalum gymnospermoides: 10.1016/S0031-9422(00)81782-3
94328 - Zingiber officinale:
311405 - Zingiber zerumbet:

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

J A Cortes-Morales, A Olmedo-Juárez, G Trejo-Tapia, M González-Cortazar, B E Domínguez-Mendoza, P Mendoza-de Gives, A Zamilpa. In vitro ovicidal activity of Baccharis conferta Kunth against Haemonchus contortus. Experimental parasitology. 2019 Feb; 197(?):20-28. doi: 10.1016/j.exppara.2019.01.003. [PMID: 30633914]
Thanh Tra Nguyen, Bich Ngan Truong, Huong Doan Thi Mai, Marc Litaudon, Van Hung Nguyen, Thao Do Thi, Van Minh Chau, Van Cuong Pham. Cytotoxic dammarane-type triterpenoids from the leaves of Viburnum sambucinum. Bioorganic & medicinal chemistry letters. 2017 04; 27(8):1665-1669. doi: 10.1016/j.bmcl.2017.03.014. [PMID: 28318944]
Linh H Mai, Guy G Chabot, Philippe Grellier, Lionel Quentin, Vincent Dumontet, Cyril Poulain, Laila S Espindola, Sylvie Michel, Hue T B Vo, Brigitte Deguin, Raphaël Grougnet. Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae). European journal of medicinal chemistry. 2015 Mar; 93(?):93-100. doi: 10.1016/j.ejmech.2015.01.012. [PMID: 25659770]
Peter Forgo, István Zupkó, Judit Molnár, Andrea Vasas, György Dombi, Judit Hohmann. Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L. Fitoterapia. 2012 Jul; 83(5):921-5. doi: 10.1016/j.fitote.2012.04.006. [PMID: 22537643]
Ghazaal Moghaddam, Soltan Ahmad Ebrahimi, Nahid Rahbar-Roshandel, Alireza Foroumadi. Antiproliferative activity of flavonoids: influence of the sequential methoxylation state of the flavonoid structure. Phytotherapy research : PTR. 2012 Jul; 26(7):1023-8. doi: 10.1002/ptr.3678. [PMID: 22184071]
Lai-Bin Zhang, Jun Ji, Chun Lei, He-Yao Wang, Qin-Shi Zhao, Ai-Jun Hou. Isoprenylated flavonoid and adipogenesis-promoting constituents of Dodonaea viscosa. Journal of natural products. 2012 Apr; 75(4):699-706. doi: 10.1021/np2009797. [PMID: 22512738]
Akhtar Muhammad, Itrat Anis, Zulfiqar Ali, Sufyan Awadelkarim, Ajmal Khan, Asaad Khalid, Muhammad Raza Shah, M Galal, Ikhlas A Khan, M Iqbal Choudhary. Methylenebissantin: a rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase. Bioorganic & medicinal chemistry letters. 2012 Jan; 22(1):610-2. doi: 10.1016/j.bmcl.2011.10.072. [PMID: 22082562]
Songpei Li, Wei Li, Yinghua Wang, Yoshihisa Asada, Kazuo Koike. Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities. Bioorganic & medicinal chemistry letters. 2010 Sep; 20(18):5398-401. doi: 10.1016/j.bmcl.2010.07.110. [PMID: 20724155]
M K Mohan Maruga Raja, Neeraj Kumar Sethiya, S H Mishra. A comprehensive review on Nymphaea stellata: A traditionally used bitter. Journal of advanced pharmaceutical technology & research. 2010 Jul; 1(3):311-9. doi: 10.4103/0110-5558.72424. [PMID: 22247863]
Luzia Kalyne Almeida Moreira Leal, Kirley Marques Canuto, Kassiane Cristine da Silva Costa, Hélio Vitoriano Nobre-Júnior, Silvânia Mendes Vasconcelos, Edilberto Rocha Silveira, Márcia Valéria Pitombeira Ferreira, Juvênia Bezerra Fontenele, Geane Matos Andrade, Glauce Socorro de Barros Viana. Effects of amburoside A and isokaempferide, polyphenols from Amburana cearensis, on rodent inflammatory processes and myeloperoxidase activity in human neutrophils. Basic & clinical pharmacology & toxicology. 2009 Mar; 104(3):198-205. doi: 10.1111/j.1742-7843.2008.00329.x. [PMID: 19053991]
Wei-Xia Song, Teng-Fei Ji, Yi-Kang Si, Ya-Lun Su. [Studies on chemical constituents in herb from Artemisia rupestris]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 Nov; 31(21):1790-2. doi: . [PMID: 17260794]
Maher M Al-Dabbas, Kanefumi Kitahara, Toshihiko Suganuma, Fumio Hashimoto, Kenjiro Tadera. Antioxidant and alpha-amylase inhibitory compounds from aerial parts of Varthemia iphionoides Boiss. Bioscience, biotechnology, and biochemistry. 2006 Sep; 70(9):2178-84. doi: 10.1271/bbb.60132. [PMID: 16960381]
Luzia K A M Leal, Melina F Costa, Márcia Pitombeira, Viviane M Barroso, Edilberto R Silveira, Kirley M Canuto, Glauce S B Viana. Mechanisms underlying the relaxation induced by isokaempferide from Amburana cearensis in the guinea-pig isolated trachea. Life sciences. 2006 May; 79(1):98-104. doi: 10.1016/j.lfs.2005.12.024. [PMID: 16455108]
Luisa Pistelli, Cecilia Noccioli, Isa Giachi, Burya Dimitrova, Reneta Gevrenova, Ivano Morelli, Donatella Potenza. Lupane-triterpenes from Bupleurum flavum. Natural product research. 2005 Dec; 19(8):783-8. doi: 10.1080/14786410500045119. [PMID: 16317832]
Jolanta Nazaruk, Piotr Jakoniuk. Flavonoid composition and antimicrobial activity of Cirsium rivulare (Jacq.) All. flowers. Journal of ethnopharmacology. 2005 Nov; 102(2):208-12. doi: 10.1016/j.jep.2005.06.012. [PMID: 16061337]
Soodabeh Saeidnia, Ahmad Reza Gohari, Michiho Ito, Fumiyuki Kiuchi, Gisho Honda. Bioactive constituents from Dracocephalum subcapitatum (O. Kuntze) Lipsky. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2005 Jan; 60(1-2):22-4. doi: 10.1515/znc-2005-1-204. [PMID: 15787238]
Dae Sik Jang, Ah-Reum Han, Gowooni Park, Gil-Ja Jhon, Eun-Kyoung Seo. Flavonoids and aromatic compounds from the rhizomes of Zingiber zerumbet. Archives of pharmacal research. 2004 Apr; 27(4):386-9. doi: 10.1007/bf02980078. [PMID: 15180302]
Letícia V Costa-Lotufo, Paula C Jimenez, Diego V Wilke, Luzia Kalyne A M Leal, Geanne M A Cunha, Edilberto R Silveira, Kirley M Canuto, Glauce S B Viana, Maria Elisabete A Moraes, Manoel Odorico de Moraes, Cláudia Pessoa. Antiproliferative effects of several compounds isolated from Amburana cearensis A. C. Smith. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2003 Sep; 58(9-10):675-80. doi: 10.1515/znc-2003-9-1014. [PMID: 14577630]
V Robin, A Irurzun, M Amoros, J Boustie, L Carrasco. Antipoliovirus flavonoids from Psiadia dentata. Antiviral chemistry & chemotherapy. 2001 Sep; 12(5):283-91. doi: 10.1177/095632020101200503. [PMID: 11900347]
. . . . doi: . [PMID: 21343428]
. . . . doi: . [PMID: 20033832]