Psoralen (BioDeep_00000398563)

Main id: BioDeep_00000000456

 

natural product PANOMIX_OTCML-2023 Antitumor activity


代谢物信息卡片


Psoralen

化学式: C11H6O3 (186.0317)
中文名称: 补骨脂素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=O)OC2=CC3=C(C=CO3)C=C21
InChI: InChI=1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H

描述信息

D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D003432 - Cross-Linking Reagents
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents > D011564 - Furocoumarins
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.856
D003879 - Dermatologic Agents
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.851
Psoralen (Ficusin) is a coumarin isolated from the seeds of Fructus Psoraleae. Psoralen exhibits a wide range of biological properties, including anti-cancer, antioxidant, antidepressant, anticancer, antibacterial, and antiviral, et al[1].
Psoralen (Ficusin) is a coumarin isolated from the seeds of Fructus Psoraleae. Psoralen exhibits a wide range of biological properties, including anti-cancer, antioxidant, antidepressant, anticancer, antibacterial, and antiviral, et al[1].

同义名列表

4 个代谢物同义名

Psoralen; Ficusin; Psoralen; Psoralen



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(2)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

429 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ABCB1, AKT1, ANXA5, BCL2, CASP3, ERCC1, PRPF19, RAD51, TP53, TYR
Peripheral membrane protein 2 ACHE, ANXA5
Endoplasmic reticulum membrane 2 BCL2, CD4
Nucleus 10 ACHE, AKT1, BCL2, CASP3, ERCC1, PCNA, PRPF19, RAD51, TP53, XPA
cytosol 6 AKT1, ANXA5, BCL2, CASP3, RAD51, TP53
nuclear body 1 PCNA
centrosome 3 PCNA, RAD51, TP53
nucleoplasm 8 AKT1, CASP3, ERCC1, PCNA, PRPF19, RAD51, TP53, XPA
Cell membrane 6 ABCB1, ACHE, AKT1, CD4, CD8A, TNF
lamellipodium 1 AKT1
Multi-pass membrane protein 1 ABCB1
Synapse 1 ACHE
cell cortex 1 AKT1
cell surface 3 ABCB1, ACHE, TNF
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 1 ACHE
Golgi membrane 1 INS
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
sarcolemma 1 ANXA5
Lysosome 1 TYR
plasma membrane 7 ABCB1, ACHE, AKT1, CD4, CD8A, IFNLR1, TNF
Membrane 8 ABCB1, ACHE, AKT1, ANXA5, BCL2, IFNLR1, PRPF19, TP53
apical plasma membrane 1 ABCB1
extracellular exosome 4 ABCB1, ANXA5, BMP3, PCNA
endoplasmic reticulum 2 BCL2, TP53
extracellular space 5 ACHE, BMP3, IL6, INS, TNF
perinuclear region of cytoplasm 3 ACHE, RAD51, TYR
mitochondrion 3 BCL2, RAD51, TP53
protein-containing complex 4 AKT1, BCL2, RAD51, TP53
intracellular membrane-bounded organelle 1 TYR
postsynaptic density 1 CASP3
Single-pass type I membrane protein 4 CD4, CD8A, IFNLR1, TYR
Secreted 4 ACHE, BMP3, IL6, INS
extracellular region 7 ACHE, ANXA5, BMP3, CD8A, IL6, INS, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
[Isoform 2]: Secreted 1 CD8A
Mitochondrion matrix 2 RAD51, TP53
mitochondrial matrix 2 RAD51, TP53
Extracellular side 1 ACHE
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 RAD51, TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 4 ANXA5, CD4, CD8A, TNF
microtubule cytoskeleton 1 AKT1
nucleolus 2 RAD51, TP53
Melanosome membrane 1 TYR
Early endosome 1 CD4
cell-cell junction 1 AKT1
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Apical cell membrane 1 ABCB1
Membrane raft 2 CD4, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
Cytoplasm, cytoskeleton, spindle 1 PRPF19
focal adhesion 1 ANXA5
spindle 2 AKT1, PRPF19
basement membrane 1 ACHE
Nucleus, PML body 1 TP53
PML body 2 RAD51, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
nuclear speck 1 PRPF19
receptor complex 1 CD8A
Zymogen granule membrane 1 ANXA5
ciliary basal body 1 AKT1
chromatin 3 PCNA, RAD51, TP53
phagocytic cup 1 TNF
Chromosome 1 RAD51
[Isoform 3]: Nucleus 1 ERCC1
nuclear replication fork 1 PCNA
chromosome, telomeric region 3 ERCC1, PCNA, RAD51
nuclear chromosome 1 RAD51
Lipid-anchor, GPI-anchor 1 ACHE
spliceosomal complex 1 PRPF19
site of double-strand break 3 PRPF19, RAD51, TP53
intercellular bridge 1 XPA
endosome lumen 1 INS
Lipid droplet 1 PRPF19
lateral element 1 RAD51
Nucleus, nucleoplasm 1 PRPF19
Melanosome 1 TYR
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 2 PCNA, TP53
myelin sheath 1 BCL2
plasma membrane raft 1 CD8A
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 CD4, IL6, INS
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
male germ cell nucleus 2 PCNA, RAD51
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
condensed nuclear chromosome 1 RAD51
[Isoform 2]: Cytoplasm 1 ERCC1
vesicle membrane 1 ANXA5
nuclear lamina 1 PCNA
clathrin-coated endocytic vesicle membrane 1 CD4
[Isoform 1]: Nucleus 2 ERCC1, TP53
synaptic cleft 1 ACHE
U2-type catalytic step 1 spliceosome 1 PRPF19
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 CD8A
catalytic step 2 spliceosome 1 PRPF19
Prp19 complex 1 PRPF19
U2-type catalytic step 2 spliceosome 1 PRPF19
condensed chromosome 1 RAD51
[Isoform 4]: Nucleus 1 ERCC1
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 2 CD4, CD8A
interleukin-6 receptor complex 1 IL6
presynaptic intermediate filament cytoskeleton 1 RAD51
ERCC4-ERCC1 complex 1 ERCC1
nucleotide-excision repair complex 1 ERCC1
nucleotide-excision repair factor 1 complex 2 ERCC1, XPA
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
[Isoform H]: Cell membrane 1 ACHE
nuclear ubiquitin ligase complex 1 RAD51
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Na Zhu, Li-Yuan Cheng, Xiao-Ying Zhang, Yue Zhang, Kun Zhou. [Pharmacokinetics of 11 active components of Psoraleae Fructus in normal and diabetic rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Mar; 49(5):1369-1377. doi: 10.19540/j.cnki.cjcmm.20231207.201. [PMID: 38621985]
  • Lei Yang, Zhaoyong Li, Chao Zhang, Shuofu Li, Long Chen, Shaofeng Yang, Yantao Guo. Psoralen synergizes with exosome-loaded SPC25 to alleviate senescence of nucleus pulposus cells in intervertebral disc degeneration. Journal of orthopaedic surgery and research. 2023 Oct; 18(1):622. doi: 10.1186/s13018-023-04085-w. [PMID: 37872583]
  • Nancy Tripathi, Nivedita Bhardwaj, Sanjay Kumar, Shreyans Kumar Jain. Phytochemical and pharmacological aspects of psoralen- A bioactive furanocoumarin from Psoralea corylifolia Linn. Chemistry & biodiversity. 2023 Sep; ?(?):e202300867. doi: 10.1002/cbdv.202300867. [PMID: 37752710]
  • Kexin Wang, Chuanhui Yin, Xiangmin Ye, Quanlin Chen, Jie Wu, Yupeng Chen, Yi Li, Jun Wang, Chuanzhi Duan, Aiping Lu, Daogang Guan. A Metabolic Driven Bio-Responsive Hydrogel Loading Psoralen for Therapy of Rheumatoid Arthritis. Small (Weinheim an der Bergstrasse, Germany). 2023 05; 19(21):e2207319. doi: 10.1002/smll.202207319. [PMID: 36869654]
  • Yujie Lu, Man Zhang, Jin Zhang, Min Jiang, Gang Bai. Psoralen prevents the inactivation of estradiol and treats osteoporosis via covalently targeting HSD17B2. Journal of ethnopharmacology. 2023 Mar; 311(?):116426. doi: 10.1016/j.jep.2023.116426. [PMID: 36997132]
  • Chunjian Zhao, Xin Li, Chunying Li, Shen Li, Yao Tian, TTingting Wang, Yujie Fu. Ingenious application of ethylenediaminetetraacetic acid disodium to improve the extraction yield of psoralen in fig (Ficus carica L.) leaves. Natural product research. 2023 Feb; 37(3):508-513. doi: 10.1080/14786419.2021.1980792. [PMID: 34546825]
  • Meng-Ying Chen, Qin Wang, Zhao-Jun Meng, Wei-Jie Men, Ju-Yang Huang, Bin Yu, Kun Zhou. Psoralen induces liver injury and affects hepatic bile acids metabolism in female and male C57BL/6J mice. Phytotherapy research : PTR. 2023 Feb; ?(?):. doi: 10.1002/ptr.7739. [PMID: 36724888]
  • Piseth Nhoek, Sungjin Ahn, Pisey Pel, Young-Mi Kim, Jungmoo Huh, Hyun Woo Kim, Minsoo Noh, Young-Won Chin. Alkaloids and Coumarins with Adiponectin-Secretion-Promoting Activities from the Leaves of Orixa japonica. Journal of natural products. 2023 01; 86(1):138-148. doi: 10.1021/acs.jnatprod.2c00844. [PMID: 36529937]
  • Avantika Pandey, Madhoolika Agrawal, Shashi Bhushan Agrawal. Individual and combined effects of chromium and ultraviolet-B radiation on defense system, ultrastructural changes, and production of secondary metabolite psoralen in a medicinal plant Psoralea corylifolia L. Environmental science and pollution research international. 2023 Jan; 30(2):4372-4385. doi: 10.1007/s11356-022-22480-4. [PMID: 35971049]
  • Jin-Fa Tang, Lu Niu, Xiao-Yan Wang, Hui Zhang, Ming-Liang Zhang, Ya-Li Wu, Xiao-Fei Chen, Ke-Ran Feng, Jin-Hao Jia, Wei-Xia Li. [Comparison on distribution of 8 components from ethanol extract of Psoraleae Fructus between normal and lipopolysaccharide-induced model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Dec; 47(24):6763-6779. doi: 10.19540/j.cnki.cjcmm.20220823.501. [PMID: 36604926]
  • Cai Zhang, Jin-Quan Zhao, Jia-Xing Sun, Hui-Jun Li. Psoralen and isopsoralen from Psoraleae Fructus aroused hepatotoxicity via induction of aryl hydrocarbon receptor-mediated CYP1A2 expression. Journal of ethnopharmacology. 2022 Oct; 297(?):115577. doi: 10.1016/j.jep.2022.115577. [PMID: 35872289]
  • Youji Jia, Guodong Wang, Wei Yan, Bo Kong, Yong Xu, Chenglong Wang, Dezhi Tang, Xiaobing Xi. Psoralen suppresses the phosphorylation of amyloid precursor protein (APP) to inhibit myelosuppression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Sep; 153(?):113381. doi: 10.1016/j.biopha.2022.113381. [PMID: 36076476]
  • Min Jiang, Xiaoying Wang, Bin Lv, Yujie Lu, Xianghui Ma, Wenjuan Liu, Gang Bai, Xiumei Gao. Psoralen induces hepatotoxicity by covalently binding to glutathione-S-transferases and the hepatic cytochrome P450. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Sep; 104(?):154165. doi: 10.1016/j.phymed.2022.154165. [PMID: 35792449]
  • Kui Huang, Bo Wu, Zhuhu Hou, Akhlaq Ahmad, Mushtaq Ahmed, Ayesha Ali Khan, Feng Tian, Fan Cheng, Wei Chu, Ke Deng. Psoralen downregulates osteoarthritis chondrocyte inflammation via an estrogen-like effect and attenuates osteoarthritis. Aging. 2022 08; 14(16):6716-6726. doi: 10.18632/aging.204245. [PMID: 36036756]
  • Atikanmu Wahefu, Rahima Abdulla, Xueying Lu, Yongqiang Liu, Haji Akber Aisa. Chemical profiling of composite prescription caraway and quantification of three pairs isomeric components in caraway administered rat plasma by tandem mass spectrometry. Journal of separation science. 2022 Aug; 45(16):3082-3094. doi: 10.1002/jssc.202200155. [PMID: 35771622]
  • Dan-Ni Wang, Jia-Ming Guo, Xin Chai, Jing Yang, Yue-Fei Wang. [Quality evaluation of Psoraleae Fructus based on QAMS method and TLC identification]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Aug; 47(15):4089-4097. doi: 10.19540/j.cnki.cjcmm.20220421.202. [PMID: 36046899]
  • Ruili Yu, Yingli Yu, Shijia Su, Lin Zhao, Qin Wang, Yue Zhang, Lei Song, Kun Zhou. Psoralen induces liver injuries through endoplasmic reticulum stress signaling in female mice. Drug and chemical toxicology. 2022 Jul; 45(4):1818-1824. doi: 10.1080/01480545.2021.1881537. [PMID: 33557643]
  • Sitong Sun, Manshu Wang, Yu Yuan, Shuo Wang, Haoran Ding, Chenrui Liang, Xiaomeng Li, Simiao Fan, Yubo Li. A new strategy for the rapid identification and validation of direct toxicity targets of psoralen-induced hepatotoxicity. Toxicology letters. 2022 Jun; 363(?):11-26. doi: 10.1016/j.toxlet.2022.05.002. [PMID: 35597499]
  • Xinna Ma, Heng Li, Ying Gong, Feifei Liu, Xiankun Tong, Fenghua Zhu, Xiaoqian Yang, Li Yang, Jianping Zuo. Psoralen inhibits hepatitis B viral replication by down-regulating the host transcriptional machinery of viral promoters. Virologica Sinica. 2022 Apr; 37(2):256-265. doi: 10.1016/j.virs.2022.01.027. [PMID: 35305922]
  • Yuhao Wang, Yonglun Wang, Fang Li, Jie Zou, Xiaoqian Li, Mengxia Xu, Daojiang Yu, Yijia Ma, Wei Huang, Xiaodong Sun, Yuanyuan Zhang. Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells. Cells. 2022 03; 11(7):. doi: 10.3390/cells11071067. [PMID: 35406631]
  • Neha Mahajan, Bhupendra Koul, Jasleen Kaur, Mahendra Bishnoi, Pankaj Gupta, Amit Kumar, Bhahwal Ali Shah, Iqra Mubeen, Ashutosh Kumar Rai, Ram Prasad, Joginder Singh. Antiobesity Potential of Bioactive Constituents from Dichloromethane Extract of Psoralea corylifolia L. Seeds. BioMed research international. 2022; 2022(?):9504787. doi: 10.1155/2022/9504787. [PMID: 36060144]
  • Shubo Li, Hongqin Tu. Psoralen inhibits the proliferation and promotes apoptosis through endoplasmic reticulum stress in human osteosarcoma cells. Folia histochemica et cytobiologica. 2022; 60(1):101-109. doi: 10.5603/fhc.a2022.0010. [PMID: 35257357]
  • Fengjie Liu, Lihong Li, Meng Lan, Tengteng Zou, Zhaodi Kong, Tiange Cai, Xiaoyu Wu, Yu Cai. Psoralen-loaded polymeric lipid nanoparticles combined with paclitaxel for the treatment of triple-negative breast cancer. Nanomedicine (London, England). 2021 11; 16(27):2411-2430. doi: 10.2217/nnm-2021-0241. [PMID: 34749510]
  • Hua Liu, Yingjie Xu, Qi Cui, Ning Liu, Fuhang Chu, Beibei Cong, Yingtao Wu. Effect of Psoralen on the Intestinal Barrier and Alveolar Bone Loss in Rats With Chronic Periodontitis. Inflammation. 2021 Oct; 44(5):1843-1855. doi: 10.1007/s10753-021-01462-7. [PMID: 33839980]
  • Ge-Zi Shi, Di Song, Peng-Yan Li, Shuai-Shuai Chen, Le Zhang, Shan-Shan Li, Xiao-He Xiao, Xu-Hua Qin, Jia-Bo Wang. Screening of hepatotoxic compounds in Psoralea corylifolia L., a traditional Chinese herbal and dietary supplement, using high-resolution mass spectrometry and high-content imaging. Biomedical chromatography : BMC. 2021 Sep; 35(9):e5140. doi: 10.1002/bmc.5140. [PMID: 33830528]
  • Wenying Gao, Zhenglong Jin, Yanxia Zheng, Youjia Xu. Psoralen inhibits the inflammatory response and mucus production in allergic rhinitis by inhibiting the activator protein 1 pathway and the downstream expression of cystatin‑SN. Molecular medicine reports. 2021 Sep; 24(3):. doi: 10.3892/mmr.2021.12291. [PMID: 34278468]
  • Lihong Li, Tengteng Zou, Min Liang, Yaroslav Mezhuev, Aristidis Michael Tsatsakis, Aleksandra Buha Đorđević, Meng Lan, Fengjie Liu, Tiange Cai, Peng Gong, Yu Cai. Screening of metabolites in the treatment of liver cancer xenografts HepG2/ADR by psoralen-loaded lipid nanoparticles. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2021 Aug; 165(?):337-344. doi: 10.1016/j.ejpb.2021.05.025. [PMID: 34062256]
  • Yang Gao, Meng-Meng Wei, Si-Yang Wu, Zheng Yuan, Shu-Yao Wang, Chen Kang, Wei Yang, Ying-Fei Li, Chuan Li. [Pharmacokinetic characteristics of psoralen,isopsoralen,psoralenoside and isopsoralenoside in rats after oral administration of Psoraleae Fructus extract]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Aug; 46(16):4244-4251. doi: 10.19540/j.cnki.cjcmm.20210318.202. [PMID: 34467739]
  • Juyang Huang, Qin Wang, Mengying Chen, Yanan Bi, Hong Shi, Kun Zhou. Effects of psoralen on hepatic bile acid transporters in rats. Human & experimental toxicology. 2021 Jun; 40(6):1012-1021. doi: 10.1177/0960327120979346. [PMID: 33317360]
  • Carter R Ellis, Dirk M Elston. Psoralen-Induced Phytophotodermatitis. Dermatitis : contact, atopic, occupational, drug. 2021 May; 32(3):140-143. doi: 10.1097/der.0000000000000691. [PMID: 33273237]
  • Xiaoyu Sui, Tingting Liu, Jicheng Liu, Jie Zhang, Honglian Zhang, Huiyu Wang, Ying Yang. Ultrasonic-enhanced surface-active ionic liquid-based extraction and defoaming for the extraction of psoralen and isopsoralen from Psoralea corylifolia seeds. Ultrasonics sonochemistry. 2020 Dec; 69(?):105263. doi: 10.1016/j.ultsonch.2020.105263. [PMID: 32711373]
  • Yongtao Lin, Lili Zhong, Hailun Li, Yong Xu, Xiang Li, Donghui Zheng. Psoralen alleviates high glucose-induced HK-2 cell injury by inhibition of Smad 2 signaling via upregulation of microRNA 874. BMC pharmacology & toxicology. 2020 07; 21(1):52. doi: 10.1186/s40360-020-00434-1. [PMID: 32698907]
  • Zhi-Xing Zhou, Li Yang, Li-Yuan Cheng, Ying-Li Yu, Lei Song, Kun Zhou, Ying-Liang Wu, Yue Zhang. Simultaneous characterization of multiple Psoraleae Fructus bioactive compounds in rat plasma by ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry for application in sex-related differences in pharmacokinetics. Journal of separation science. 2020 Jul; 43(14):2804-2816. doi: 10.1002/jssc.202000286. [PMID: 32384213]
  • Pei-Shi Liang, Wang Zhou, Zhen-Zhou Jiang, Lu-Yong Zhang. [Mechanism of psoralen in aggravating hepatotoxicity induced by CCl_4 by delaying liver regeneration]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Jun; 45(12):2916-2923. doi: 10.19540/j.cnki.cjcmm.20200115.401. [PMID: 32627467]
  • Christina L Dean, Jay W Hooper, John M Dye, Samantha E Zak, Scott A Koepsell, Laurence Corash, Richard J Benjamin, Steve Kwilas, Shannon Bonds, Anne M Winkler, Colleen S Kraft. Characterization of Ebola convalescent plasma donor immune response and psoralen treated plasma in the United States. Transfusion. 2020 05; 60(5):1024-1031. doi: 10.1111/trf.15739. [PMID: 32129478]
  • Xi-Yang Tang, Zi-Qin Dai, Qing-Chang Wu, Jia-Xing Zeng, Meng-Xue Gao, Hui-Hui Xiao, Zhi-Hong Yao, Yi Dai, Xin-Sheng Yao. Simultaneous determination of multiple components in rat plasma and pharmacokinetic studies at a pharmacodynamic dose of Xian-Ling-Gu-Bao capsule by UPLC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2020 Jan; 177(?):112836. doi: 10.1016/j.jpba.2019.112836. [PMID: 31473481]
  • Abhinay Thakur, Rohit Sharma, Vivek Sheel Jaswal, Eugenie Nepovimova, Ashun Chaudhary, Kamil Kuca. Psoralen: A Biologically Important Coumarin with Emerging Applications. Mini reviews in medicinal chemistry. 2020; 20(18):1838-1845. doi: 10.2174/1389557520666200429101053. [PMID: 32348216]
  • Yingli Yu, Ruili Yu, Weijie Men, Panyang Zhang, Yue Zhang, Lei Song, Kun Zhou. Psoralen induces hepatic toxicity through PERK and ATF6 related ER stress pathways in HepG2 cells. Toxicology mechanisms and methods. 2020 Jan; 30(1):39-47. doi: 10.1080/15376516.2019.1650150. [PMID: 31364909]
  • Lei Song, Bin Yu, Li Yang, Zhao-Xin Wang, Yue Zhang, Ying-Li Yu, Kun Zhou. The mechanism of Psoralen and Isopsoralen hepatotoxicity as revealed by hepatic gene expression profiling in SD rats. Basic & clinical pharmacology & toxicology. 2019 Dec; 125(6):527-535. doi: 10.1111/bcpt.13287. [PMID: 31271704]
  • Lu Liu, Lei Zhang, Ze-Xu Cui, Xiao-Yan Liu, Wei Xu, Xiu-Wei Yang. Transformation of Psoralen and Isopsoralen by Human Intestinal Microbial In Vitro, and the Biological Activities of Its Metabolites. Molecules (Basel, Switzerland). 2019 Nov; 24(22):. doi: 10.3390/molecules24224080. [PMID: 31718071]
  • Unwoo Kang, Ah-Reum Han, Yangkang So, Chang Hyun Jin, Seung Mok Ryu, Dongho Lee, Eun Kyoung Seo. Furanocoumarins from the Roots of Angelica dahurica with Inhibitory Activity against Intracellular Reactive Oxygen Species Accumulation. Journal of natural products. 2019 09; 82(9):2601-2607. doi: 10.1021/acs.jnatprod.9b00547. [PMID: 31464439]
  • Diána Kerekes, Attila Csorba, Beáta Gosztola, Éva Németh-Zámbori, Tivadar Kiss, Dezső Csupor. Furocoumarin Content of Fennel-Below the Safety Threshold. Molecules (Basel, Switzerland). 2019 Aug; 24(15):. doi: 10.3390/molecules24152844. [PMID: 31387269]
  • Xiaomin Wang, Peike Peng, Zhiqiang Pan, Zhaoqin Fang, Wenli Lu, Xiaomei Liu. Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells. Biological research. 2019 Jul; 52(1):34. doi: 10.1186/s40659-019-0241-8. [PMID: 31277690]
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