Genistein (BioDeep_00000397994)

Main id: BioDeep_00000000259

Secondary id: BioDeep_00000859693

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


Sophoricol

化学式: C15H10O5 (270.0528)
中文名称: 金雀异黄酮, 染料木素
谱图信息: 最多检出来源 Homo sapiens(blood) 12.91%

分子结构信息

SMILES: C1(=CC2=C(C(=C1)O)C(C(=CO2)C3=CC=C(C=C3)O)=O)O
InChI: InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H

描述信息

C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1821 - Selective Estrogen Receptor Modulator
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
D020011 - Protective Agents > D016588 - Anticarcinogenic Agents
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
D000970 - Antineoplastic Agents
C1892 - Chemopreventive Agent
Disclaimer: While authors make an effort to ensure that the content of this record is accurate, the authors make no representations or warranties in relation to the accuracy or completeness of the record. This record do not reflect any viewpoints of the affiliation and organization to which the authors belong.
Acquisition and generation of the data is financially supported by the Max-Planck-Society
IPB_RECORD: 2181; CONFIDENCE confident structure
Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.
Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.

同义名列表

4 个代谢物同义名

Genistein; Sophoricol; NPI 031L; Genistein



数据库引用编号

117 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

822 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 CFTR, CTNNB1, MYLK, NFKB1, NOS3, PGR, PIK3C3, PIK3CA, PRL, PTK2, STAT3, TNK1
Peripheral membrane protein 2 PTK2, TNK1
Endosome membrane 1 CFTR
Endoplasmic reticulum membrane 1 CFTR
Mitochondrion membrane 1 ABCG2
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 11 CFTR, CTNNB1, ESR2, JUN, NFKB1, NOS3, PGR, PLCZ1, PRL, PTK2, STAT3
autophagosome 1 PIK3C3
cytosol 12 CFTR, CTNNB1, MYLK, NFKB1, NOS3, PGR, PIK3C3, PIK3CA, PLCZ1, PRKCQ, PTK2, STAT3
mitochondrial membrane 1 ABCG2
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
centrosome 2 CTNNB1, PTK2
nucleoplasm 10 ABCG2, CTNNB1, ESR2, JUN, NFKB1, NOS3, PGR, PLCZ1, PRL, STAT3
RNA polymerase II transcription regulator complex 3 JUN, PRL, STAT3
Cell membrane 4 ABCG2, CFTR, CTNNB1, PTK2
Cytoplasmic side 1 PTK2
Cleavage furrow 1 MYLK
lamellipodium 3 CTNNB1, MYLK, PIK3CA
Early endosome membrane 1 CFTR
Multi-pass membrane protein 2 ABCG2, CFTR
Synapse 2 CTNNB1, MYLK
cell cortex 2 CTNNB1, PTK2
cell junction 1 CTNNB1
cell surface 1 CFTR
glutamatergic synapse 2 CTNNB1, PIK3C3
Golgi apparatus 1 NOS3
Golgi membrane 2 INS, NOS3
lysosomal membrane 2 CFTR, EGF
presynaptic membrane 1 CTNNB1
endosome 1 PIK3C3
plasma membrane 13 ABCG2, CFTR, CTNNB1, EGF, MYLK, NOS3, PGR, PIK3CA, PRKCQ, PTK2, STAT3, TNFRSF11B, TNK1
Membrane 6 ABCG2, CFTR, CTNNB1, EGF, PIK3C3, TNK1
apical plasma membrane 2 ABCG2, CFTR
basolateral plasma membrane 1 CTNNB1
caveola 1 NOS3
extracellular exosome 2 CTNNB1, EGF
extracellular space 4 EGF, INS, PRL, TNFRSF11B
perinuclear region of cytoplasm 5 CTNNB1, NOS3, PIK3CA, PLCZ1, PTK2
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 2 ESR2, NFKB1
protein-containing complex 2 CFTR, CTNNB1
intracellular membrane-bounded organelle 2 ESR2, PTK2
pronucleus 1 PLCZ1
Secreted 3 INS, PRL, TNFRSF11B
extracellular region 5 EGF, INS, NFKB1, PRL, TNFRSF11B
mitochondrial outer membrane 1 PGR
anchoring junction 1 PTK2
transcription regulator complex 4 CTNNB1, JUN, NFKB1, STAT3
centriolar satellite 1 PRKCQ
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 PTK2
actin cytoskeleton 1 MYLK
dendritic spine 1 PTK2
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 1 PLCZ1
Wnt signalosome 1 CTNNB1
midbody 1 PIK3C3
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Early endosome 1 CFTR
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
recycling endosome 1 CFTR
postsynaptic membrane 1 CTNNB1
Apical cell membrane 2 ABCG2, CFTR
Cell projection, lamellipodium 1 MYLK
Cytoplasm, perinuclear region 2 PLCZ1, PTK2
Membrane raft 1 ABCG2
Cell junction, focal adhesion 1 PTK2
Cytoplasm, cytoskeleton 2 CTNNB1, PTK2
focal adhesion 2 CTNNB1, PTK2
GABA-ergic synapse 1 PIK3C3
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
extracellular matrix 1 TNFRSF11B
Peroxisome 1 PIK3C3
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
axoneme 1 PIK3C3
Late endosome 1 PIK3C3
receptor complex 1 TNFRSF11B
ciliary basal body 1 PTK2
chromatin 6 ESR2, JUN, NFKB1, PGR, PRL, STAT3
cell projection 1 PTK2
phagocytic vesicle membrane 1 PIK3C3
cell periphery 1 CTNNB1
cytoskeleton 2 NOS3, PTK2
Cytoplasm, cytoskeleton, cilium basal body 2 CTNNB1, PTK2
brush border membrane 1 ABCG2
spindle pole 1 CTNNB1
nuclear chromosome 1 JUN
Cytoplasm, cell cortex 1 PTK2
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
Recycling endosome membrane 1 CFTR
Endomembrane system 1 CTNNB1
endosome lumen 2 INS, PRL
chloride channel complex 1 CFTR
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Golgi-associated vesicle membrane 1 CFTR
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
euchromatin 2 CTNNB1, JUN
stress fiber 2 MYLK, PTK2
secretory granule lumen 2 INS, NFKB1
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
platelet alpha granule lumen 1 EGF
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 NFKB1
endocytic vesicle membrane 1 NOS3
transport vesicle 1 INS
beta-catenin-TCF complex 1 CTNNB1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
presynaptic endosome 1 PIK3C3
aggresome 1 PRKCQ
presynaptic active zone cytoplasmic component 1 CTNNB1
clathrin-coated endocytic vesicle membrane 2 CFTR, EGF
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
protein-DNA complex 1 CTNNB1
external side of apical plasma membrane 1 ABCG2
catenin complex 1 CTNNB1
postsynaptic endosome 1 PIK3C3
transcription factor AP-1 complex 1 JUN
Autolysosome 1 PIK3C3
sperm head 1 PLCZ1
[Isoform 4]: Mitochondrion outer membrane 1 PGR
beta-catenin-TCF7L2 complex 1 CTNNB1
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Gaoxuan Shao, Ying Liu, Lu Lu, Lei Wang, Guang Ji, Hanchen Xu. Therapeutic potential of traditional Chinese medicine in the prevention and treatment of digestive inflammatory cancer transformation: Portulaca oleracea L. as a promising drug. Journal of ethnopharmacology. 2024 Jun; 327(?):117999. doi: 10.1016/j.jep.2024.117999. [PMID: 38447616]
  • Palash Mandal, David A Mortensen, André F Brito, Anna K Wallingford, Marta R M Lima, Nicholas D Warren, Richard G Smith. Water Stress Influences Phytoestrogen Levels in Red Clover (Trifolium pratense) but Not Kura Clover (T. ambiguum). Journal of agricultural and food chemistry. 2024 May; 72(18):10247-10256. doi: 10.1021/acs.jafc.4c00300. [PMID: 38683760]
  • Xue Li, Le Liu, Mei-Xuan Wan, Li-Min Gong, Juan Su, Li Xu. Active Components of Pueraria lobata through the MAPK/ERK Signaling Pathway Alleviate Iron Overload in Alcoholic Liver Disease. Chemistry & biodiversity. 2024 May; 21(5):e202400005. doi: 10.1002/cbdv.202400005. [PMID: 38504590]
  • Yaning Wu, Hongwei Zhang, Jianguang Zhu, Zhenling Zhang, Songbo Ma, Yongqi Zhao, Yiming Wang, Jun Yuan, Xing Guo, Yajing Li, Shuai Zhang. The Effect of Fermentation on the Chemical Constituents of Gastrodia Tuber Hallimasch Powder (GTHP) Estimated by UHPLC-Q-Orbitrap HRMS and HPLC. Molecules (Basel, Switzerland). 2024 Apr; 29(7):. doi: 10.3390/molecules29071663. [PMID: 38611942]
  • Yun Bo Zhang, Jiang Li Li, Jie Tian, Xiao Lin Na. Effect of Maternal DEHP Exposure on Lipid Metabolism in Adult Male Rats and the Antagonistic Effect of Genistein. Biomedical and environmental sciences : BES. 2024 Mar; 37(3):315-319. doi: 10.3967/bes2024.034. [PMID: 38582995]
  • Jamie Gudyka, Jasmin Ceja-Vega, Katherine Ivanchenko, Wilber Perla, Christopher Poust, Alondra Gamez Hernandez, Colleen Clarke, Shakinah Silverberg, Escarlin Perez, Sunghee Lee. Differential Effects of Soy Isoflavones on the Biophysical Properties of Model Membranes. The journal of physical chemistry. B. 2024 Mar; 128(10):2412-2424. doi: 10.1021/acs.jpcb.3c08390. [PMID: 38417149]
  • Magdalena Wójciak, Piotr Drozdowski, Aleksandra Ziemlewska, Martyna Zagórska-Dziok, Zofia Nizioł-Łukaszewska, Tomasz Kubrak, Ireneusz Sowa. ROS Scavenging Effect of Selected Isoflavones in Provoked Oxidative Stress Conditions in Human Skin Fibroblasts and Keratinocytes. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29050955. [PMID: 38474467]
  • Nopawit Khamto, Kraikrit Utama, Panida Boontawee, Atchara Janthong, Suriya Tatieng, Supakorn Arthan, Vachira Choommongkol, Padchanee Sangthong, Chavi Yenjai, Nuttee Suree, Puttinan Meepowpan. Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CLpro: Insights from the Computational and Experimental Investigations. Journal of chemical information and modeling. 2024 Jan; ?(?):. doi: 10.1021/acs.jcim.3c01477. [PMID: 38277124]
  • Eman Shawky, Rasha A Nassra, Aliaa M T El-Alkamy, Shaimaa M Sallam, Samah M El Sohafy. Unraveling the mechanisms of Fenugreek seed for managing different gynecological disorders: steroidal saponins and isoflavones revealed as key bioactive metabolites. Journal of pharmaceutical and biomedical analysis. 2024 Jan; 238(?):115865. doi: 10.1016/j.jpba.2023.115865. [PMID: 38000191]
  • Ida K L Andersen, Inge S Fomsgaard, Jim Rasmussen. Intercropping of Narrow-Leafed Lupin (Lupinus angustifolius L.) and Barley (Hordeum vulgare L.) Affects the Flavonoid Composition of Both Crops. Journal of agricultural and food chemistry. 2024 Jan; 72(1):108-115. doi: 10.1021/acs.jafc.3c03684. [PMID: 38146912]
  • Canhong Wang, Bao Gong, Yulan Wu, Congwen Bai, Meihua Yang, Xiangsheng Zhao, Jianhe Wei. Pharmacokinetics and molecular docking of the cardioprotective flavonoids in Dalbergia odorifera. Journal of separation science. 2024 Jan; 47(1):e2300614. doi: 10.1002/jssc.202300614. [PMID: 38066409]
  • Longlong Li, Ze Lu, Yulei Wang, Ying Yang, Huihui Wang, Haitian Ma. Genistein alleviates chronic heat stress-induced lipid metabolism disorder and mitochondrial energetic dysfunction by activating the GPR30-AMPK-PGC-1α signaling pathways in the livers of broiler chickens. Poultry science. 2024 Jan; 103(1):103251. doi: 10.1016/j.psj.2023.103251. [PMID: 37984004]
  • Yilin Chen, Fengwei Zhang, Jijia Sun, Lei Zhang. Identifying the natural products in the treatment of atherosclerosis by increasing HDL-C level based on bioinformatics analysis, molecular docking, and in vitro experiment. Journal of translational medicine. 2023 Dec; 21(1):920. doi: 10.1186/s12967-023-04755-7. [PMID: 38115108]
  • Worapol Sae-Foo, Sukritta Singkham, Pimsiri Srisongkhram, Gorawit Yusakul, Pisitchai Masugarut, Waraporn Putalun. Development and characterisation of highly specific monoclonal antibody-based immunoassays for the detection and quantification of genistein-7-O-[α-rhamnopyranosyl-(1→6)]-β-glucopyranoside in Derris scandens (Roxb.) Benth. Phytochemical analysis : PCA. 2023 Nov; ?(?):. doi: 10.1002/pca.3305. [PMID: 37965872]
  • Haruna Nagayoshi, Norie Murayama, Vitchan Kim, Donghak Kim, Shigeo Takenaka, Hiroshi Yamazaki, F Peter Guengerich, Tsutomu Shimada. Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1. Chemical research in toxicology. 2023 Oct; ?(?):. doi: 10.1021/acs.chemrestox.3c00229. [PMID: 37783573]
  • Tong Xuan, Yuhan Liu, Rui Liu, Sheng Liu, Jiaqi Han, Xinyu Bai, Jie Wu, Ronghua Fan. Advances in Extraction, Purification, and Analysis Techniques of the Main Components of Kudzu Root: A Comprehensive Review. Molecules (Basel, Switzerland). 2023 Sep; 28(18):. doi: 10.3390/molecules28186577. [PMID: 37764353]
  • Shun Watanabe, Riki Haruyama, Koji Umezawa, Ikuo Tomioka, Soichiro Nakamura, Shigeru Katayama, Takakazu Mitani. Genistein enhances NAD+ biosynthesis by upregulating nicotinamide phosphoribosyltransferase in adipocytes. The Journal of nutritional biochemistry. 2023 Aug; 121(?):109433. doi: 10.1016/j.jnutbio.2023.109433. [PMID: 37648097]
  • Yaoyao Ren, Shengtao Qu. Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: Evidence from preclinical studies. Ageing research reviews. 2023 Aug; 90(?):102040. doi: 10.1016/j.arr.2023.102040. [PMID: 37619620]
  • Yi Wei, Yongfa Liu, Guang Li, Yuming Guo, Bingkun Zhang. Effects of quercetin and genistein on egg quality, lipid profiles and immunity in laying hens. Journal of the science of food and agriculture. 2023 Aug; ?(?):. doi: 10.1002/jsfa.12910. [PMID: 37552763]
  • Gabriella Magarelli, Cínthia Caetano Bonatto, Gabriela Mendes da Rocha Vaz, Victoria Baggi Mendonça Lauria, Luciano Paulino Silva. Unveiling the Remarkable Antioxidant Activity of Plant-Based Fish and Seafood Analogs through Electrochemical Sensor Analysis. Biosensors. 2023 Jul; 13(7):. doi: 10.3390/bios13070751. [PMID: 37504149]
  • Fei Teng, Zhongwen Lu, Fei Gao, Jing Liang, Jiawen Li, Xuanhe Tian, Xianshuai Wang, Haowei Guan, Jin Wang. Systems biology approaches to identify potential targets and inhibitors of the intestinal microbiota to treat depression. Scientific reports. 2023 07; 13(1):11225. doi: 10.1038/s41598-023-38444-8. [PMID: 37433869]
  • Ana Ruiz de la Bastida, Susana Langa, Ángela Peirotén, Raúl Fernández-Gonzalez, Abel Sánchez-Jiménez, María Maroto, José Antonio Curiel, Eva Guillamon, Juan Luis Arqués, Alfonso Gutiérrez-Adán, José María Landete. Effect of fermented soy beverage in aged female mice model. Food research international (Ottawa, Ont.). 2023 07; 169(?):112745. doi: 10.1016/j.foodres.2023.112745. [PMID: 37254374]
  • Iskandar Azmy Harahap, Maciej Kuligowski, Marcin Schmidt, Joanna Suliburska. The impact of soy products, isoflavones, and Lactobacillus acidophilus on iron status and morphological parameters in healthy female rats. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2023 Jul; 78(?):127183. doi: 10.1016/j.jtemb.2023.127183. [PMID: 37120971]
  • Longlong Li, Yulei Wang, Huihui Wang, Ying Yang, Haitian Ma. Protective effects of genistein on the production performance and lipid metabolism disorders in laying hens with fatty liver hemorrhagic syndrome by activation of the GPER-AMPK signaling pathways. Journal of animal science. 2023 Jun; ?(?):. doi: 10.1093/jas/skad197. [PMID: 37314978]
  • Chiagoziem A Otuechere, Netra P Neupane, Adewale Adewuyi, Prateek Pathak, Jurica Novak, Maria Grishina, Habibullah Khalilullah, Mariusz Jaremko, Amita Verma. Green Synthesis of Genistein-Fortified Zinc Ferrite Nanoparticles as a Potent Hepatic Cancer Inhibitor: Validation through Experimental and Computational Studies. Chemistry & biodiversity. 2023 Jun; ?(?):e202300719. doi: 10.1002/cbdv.202300719. [PMID: 37312449]
  • Arthur Neuberger, Yury A Trofimov, Maria V Yelshanskaya, Kirill D Nadezhdin, Nikolay A Krylov, Roman G Efremov, Alexander I Sobolevsky. Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein. Nature communications. 2023 May; 14(1):2659. doi: 10.1038/s41467-023-38352-5. [PMID: 37160865]
  • Lijuan Shi, Zhen Lin, Jiantong Hou, Wenhui Liu, Jing Xu, Yuanqiang Guo. Purification and characterization of chicory polysaccharide and its application in stabling genistein for cancer therapy. International journal of biological macromolecules. 2023 Apr; ?(?):124635. doi: 10.1016/j.ijbiomac.2023.124635. [PMID: 37121414]
  • Hong Qin, Ziyu Song, Chunyu Zhao, Sha Li, Anwar Ali, Wenya Zheng. miR-363-3p/PTEN is involved in the regulation of lipid metabolism by genistein in HepG2 cells via ERβ. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Apr; 115(?):154839. doi: 10.1016/j.phymed.2023.154839. [PMID: 37121060]
  • Dionysios T Pavlopoulos, Eleni D Myrtsi, Paschalitsa Tryfinopoulou, Vasilios Iliopoulos, Sofia D Koulocheri, Serkos A Haroutounian. Phytoestrogens as Biomarkers of Plant Raw Materials Used for Fish Feed Production. Molecules (Basel, Switzerland). 2023 Apr; 28(8):. doi: 10.3390/molecules28083623. [PMID: 37110857]
  • Mohd Farhan, Mohamed El Oirdi, Mohammad Aatif, Insha Nahvi, Ghazala Muteeb, Mir Waqas Alam. Soy Isoflavones Induce Cell Death by Copper-Mediated Mechanism: Understanding Its Anticancer Properties. Molecules (Basel, Switzerland). 2023 Mar; 28(7):. doi: 10.3390/molecules28072925. [PMID: 37049690]
  • Masahiko Taniguchi, Connor A LaRocca, Jake D Bernat, Jonathan S Lindsey. Digital Database of Absorption Spectra of Diverse Flavonoids Enables Structural Comparisons and Quantitative Evaluations. Journal of natural products. 2023 Feb; ?(?):. doi: 10.1021/acs.jnatprod.2c00720. [PMID: 36848595]
  • Tingting Chen, Juan Wang, Min Li, Qingqing Wu, Shuna Cui. Genistein Inhibits Proliferation and Metastasis in Human Cervical Cancer Cells through the Focal Adhesion Kinase Signaling Pathway: A Network Pharmacology-Based In Vitro Study in HeLa Cells. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041919. [PMID: 36838908]
  • Nithiwat Suntichaikamolkul, Tomoyoshi Akashi, Panupong Mahalapbutr, Kamonpan Sanachai, Thanyada Rungrotmongkol, Jean-Etienne Bassard, Hubert Schaller, Wanchai De-Eknamkul, Sornkanok Vimolmangkang, Mami Yamazaki, Supaart Sirikantaramas. Daidzein Hydroxylation by CYP81E63 Is Involved in the Biosynthesis of Miroestrol in Pueraria mirifica. Plant & cell physiology. 2023 Feb; 64(1):64-79. doi: 10.1093/pcp/pcac140. [PMID: 36218384]
  • Tharindu L Suraweera, J P Jose Merlin, Graham Dellaire, Zhaolin Xu, H P Vasantha Rupasinghe. Genistein and Procyanidin B2 Reduce Carcinogen-Induced Reactive Oxygen Species and DNA Damage through the Activation of Nrf2/ARE Cell Signaling in Bronchial Epithelial Cells In Vitro. International journal of molecular sciences. 2023 Feb; 24(4):. doi: 10.3390/ijms24043676. [PMID: 36835090]
  • Mengying Wang, Biying Dong, Zhihua Song, Meng Qi, Ting Chen, Tingting Du, Hongyan Cao, Ni Liu, Dong Meng, Qing Yang, Yujie Fu. Molecular mechanism of naringenin regulation on flavonoid biosynthesis to improve the salt tolerance in pigeon pea (Cajanus cajan (Linn.) Millsp.). Plant physiology and biochemistry : PPB. 2023 Feb; 196(?):381-392. doi: 10.1016/j.plaphy.2023.02.002. [PMID: 36746009]
  • Xinyi Guo. Antibacterial and anti-inflammatory effects of genistein in Staphylococcus aureus induced osteomyelitis in rats. Journal of biochemical and molecular toxicology. 2023 Feb; ?(?):e23298. doi: 10.1002/jbt.23298. [PMID: 36727417]
  • Parth Malik, Raj Singh, Mukesh Kumar, Anuj Malik, Tapan Kumar Mukherjee. Understanding the phytoestrogen genistein actions on breast cancer: Insights on estrogen receptor equivalence, pleiotropic essence and emerging paradigms in bioavailability modulation. Current topics in medicinal chemistry. 2023 Jan; ?(?):. doi: 10.2174/1568026623666230103163023. [PMID: 36597609]
  • Yuan Cheng, Yi Tang, Yiming Tan, Juan Li, Xuping Zhang. KCNK9 mediates the inhibitory effects of genistein on hepatic metastasis from colon cancer. Clinics (Sao Paulo, Brazil). 2023; 78(?):100141. doi: 10.1016/j.clinsp.2022.100141. [PMID: 36905879]
  • Jia Xiang, Ronald Mlambo, Progress Dube, Oleen Machona, Ibrahim Shaw, Yimer Seid, Yongju He, Min Luo, Tingting Hong, Binsheng He, Wenhu Zhou, Songwen Tan. The obesogenic side of Genistein. Frontiers in endocrinology. 2023; 14(?):1308341. doi: 10.3389/fendo.2023.1308341. [PMID: 38098865]
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