Amentoflavone (BioDeep_00000003345)

 

Secondary id: BioDeep_00000330658

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


4H-1-Benzopyran-4-one, 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-

化学式: C30H18O10 (538.09)
中文名称: 阿曼托黄酮, 穗花杉双黄酮
谱图信息: 最多检出来源 Viridiplantae(plant) 37.04%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(cc2=O)c1cc(c(cc1)O)c1c(cc(c2c1oc(cc2=O)c1ccc(cc1)O)O)O)O)O
InChI: InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H

描述信息

Amentoflavone is a biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-8 of the chromene ring. A natural product found particularly in Ginkgo biloba and Hypericum perforatum. It has a role as a cathepsin B inhibitor, an antiviral agent, an angiogenesis inhibitor, a P450 inhibitor and a plant metabolite. It is a biflavonoid, a hydroxyflavone and a ring assembly.
Amentoflavone is a natural product found in Podocarpus elongatus, Austrocedrus chilensis, and other organisms with data available.
A biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-8 of the chromene ring. A natural product found particularly in Ginkgo biloba and Hypericum perforatum.
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065688 - Cytochrome P-450 CYP2C9 Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065692 - Cytochrome P-450 CYP3A Inhibitors
Amentoflavone is found in fruits. Amentoflavone is obtained from Viburnum prunifolium (black haw
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase[1][2][3][4].
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase[1][2][3][4].
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase[1][2][3][4].

同义名列表

32 个代谢物同义名

4H-1-Benzopyran-4-one, 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-; 4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-; 4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl); 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 8-[5-(5,7-dihydroxy-4-oxo-chromen-2-yl)-2-hydroxy-phenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one;Amentoflavone; 8-[5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 8-[5-(5,7-dihydroxy-4-oxo-chromen-2-yl)-2-hydroxy-phenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one; 8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one; 4,5,7-Trihydroxyflavone(3->8)-4,5,7-trihydroxyflavone; 8-(5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2; 4,4,5,5,7,7-Hexahydroxy-3,8-biflavone, 8CI; 3,8-BIFLAVONE, 4,4,5,5,7,7-HEXAHYDROXY; (4-hydroxyphenyl)-4H-chromen-4-one; Amentoflavone, analytical standard; -hydroxyphenyl)-5,7-dihydroxy-2-; 3,8-Bi[4,5,7-trihydroxyflavone]; Amentoflavone, >=99.0\\% (HPLC); YUSWMAULDXZHPY-UHFFFAOYSA-N; Tridemethylsciadopitysin; GINKGETIN, DIDEMETHYL-; AMENTOFLAVONE [INCI]; Didemethyl-ginkgetin; I3,II8-BIAPIGENIN; UNII-9I1VC79L77; 3,8-Biapigenin; Amenthoflavone; MEGxp0_000924; Amentoflavone; Ametoflavone; 9I1VC79L77; Amentoflavone



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

632 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 BCL2, CASP3, CCND1, MAPK14, MTOR, NFE2L2, PIK3CA, PRKAA2, PTGS2, STAT3, TP53, VEGFA
Peripheral membrane protein 4 ACHE, GORASP1, MTOR, PTGS2
Endoplasmic reticulum membrane 4 BCL2, HMOX1, MTOR, PTGS2
Nucleus 13 ACHE, BCL2, CASP3, CCND1, FOS, HMOX1, MAPK14, MTOR, NFE2L2, PRKAA2, STAT3, TP53, VEGFA
cytosol 12 BCL2, CASP3, CCND1, FOS, HMOX1, MAPK14, MTOR, NFE2L2, PIK3CA, PRKAA2, STAT3, TP53
dendrite 2 MTOR, PRKAA2
phagocytic vesicle 1 MTOR
centrosome 3 CCND1, NFE2L2, TP53
nucleoplasm 10 CASP3, CCND1, FOS, HMOX1, MAPK14, MTOR, NFE2L2, PRKAA2, STAT3, TP53
RNA polymerase II transcription regulator complex 3 FOS, NFE2L2, STAT3
Cell membrane 2 ACHE, TNF
Cytoplasmic side 3 GORASP1, HMOX1, MTOR
lamellipodium 1 PIK3CA
Golgi apparatus membrane 2 GORASP1, MTOR
Synapse 1 ACHE
cell surface 3 ACHE, TNF, VEGFA
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 5 ACHE, GORASP1, NFE2L2, PRKAA2, VEGFA
Golgi membrane 3 GORASP1, INS, MTOR
lysosomal membrane 1 MTOR
neuromuscular junction 1 ACHE
neuronal cell body 3 CASP3, PRKAA2, TNF
Cytoplasm, cytosol 1 NFE2L2
Lysosome 1 MTOR
plasma membrane 5 ACHE, NFE2L2, PIK3CA, STAT3, TNF
Membrane 7 ACHE, BCL2, HMOX1, MTOR, PRKAA2, TP53, VEGFA
axon 1 PRKAA2
caveola 1 PTGS2
Lysosome membrane 1 MTOR
endoplasmic reticulum 6 BCL2, FOS, HMOX1, PTGS2, TP53, VEGFA
extracellular space 6 ACHE, HMOX1, IL6, INS, TNF, VEGFA
perinuclear region of cytoplasm 3 ACHE, HMOX1, PIK3CA
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, MAPK14, TP53
protein-containing complex 3 BCL2, PTGS2, TP53
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 4 ACHE, IL6, INS, VEGFA
extracellular region 6 ACHE, IL6, INS, MAPK14, TNF, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
Extracellular side 1 ACHE
transcription regulator complex 2 STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
nucleolus 1 TP53
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
cis-Golgi network 1 GORASP1
extracellular matrix 1 VEGFA
basement membrane 1 ACHE
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
secretory granule 1 VEGFA
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
chromatin 4 FOS, NFE2L2, STAT3, TP53
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
spindle pole 1 MAPK14
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 TP53
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
cytoplasmic stress granule 1 PRKAA2
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
nuclear matrix 2 FOS, TP53
transcription repressor complex 2 CCND1, TP53
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
[Isoform 1]: Nucleus 1 TP53
synaptic cleft 1 ACHE
protein-DNA complex 2 FOS, NFE2L2
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, phagosome 1 MTOR
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
transcription factor AP-1 complex 1 FOS
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Chie Aoki-Utsubo, Puguh Indrasetiawan, Kento Fukano, Masamichi Muramatsu, Nina Artanti, Muhammad Hanafi, Hak Hotta, Masanori Kameoka. Amentoflavone inhibits hepatitis B virus infection via the suppression of preS1 binding to host cells. Microbiology and immunology. 2023 Mar; ?(?):. doi: 10.1111/1348-0421.13064. [PMID: 36929353]
  • Hardeep Singh Tuli, Hemant Joshi, Kanupriya Vashishth, Seema Ramniwas, Mehmet Varol, Manoj Kumar, Isha Rani, Vibha Rani, Katrin Sak. Chemopreventive mechanisms of amentoflavone: recent trends and advancements. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Feb; ?(?):. doi: 10.1007/s00210-023-02416-6. [PMID: 36773053]
  • Wang Tingting, Fang Tianqi, Wang Xinyu, Zhang Can, Shen Xue, Deng Xuming, Wang Jianfeng. Amentoflavone attenuates Listeria monocytogenes pathogenicity through an LLO-dependent mechanism. British journal of pharmacology. 2022 07; 179(14):3839-3858. doi: 10.1111/bph.15827. [PMID: 35229287]
  • Dipta Dey, Rajib Hossain, Partha Biswas, Priyanka Paul, Md Aminul Islam, Tanzila Ismail Ema, Bibhuti Kumar Gain, Mohammad Mehedi Hasan, Shabana Bibi, Muhammad Torequl Islam, Md Ataur Rahman, Bonglee Kim. Amentoflavone derivatives significantly act towards the main protease (3CLPRO/MPRO) of SARS-CoV-2: in silico admet profiling, molecular docking, molecular dynamics simulation, network pharmacology. Molecular diversity. 2022 May; ?(?):. doi: 10.1007/s11030-022-10459-9. [PMID: 35639226]
  • Qi Sun, Peng Zhen, Dandan Li, Xiaochen Liu, Xinling Ding, Huihui Liu. Amentoflavone promotes ferroptosis by regulating reactive oxygen species (ROS) /5'AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) to inhibit the malignant progression of endometrial carcinoma cells. Bioengineered. 2022 05; 13(5):13269-13279. doi: 10.1080/21655979.2022.2079256. [PMID: 35635082]
  • Chun-Yu Li, Hao-Nan Wang, Rong-Jing He, Jian Huang, Li-Lin Song, Yun-Qing Song, Peng-Chao Huo, Jie Hou, Guang Ji, Guang-Bo Ge. Discovery and characterization of amentoflavone as a naturally occurring inhibitor against the bile salt hydrolase produced by Lactobacillus salivarius. Food & function. 2022 Mar; 13(6):3318-3328. doi: 10.1039/d1fo03277a. [PMID: 35257124]
  • Yasmin Silva Rizk, Daiana de Jesus Hardoim, Kaique Bertrand Almeida Santos, Tânia Zaverucha-do-Valle, Noemi Nosomi Taniwaki, Fernando Almeida-Souza, Carlos Alexandre Carollo, Marcos André Vannier-Santos, Carla Cardozo Pinto de Arruda, Kátia da Silva Calabrese. Amentoflavone isolated from Selaginella sellowii Hieron induces mitochondrial dysfunction in Leishmania amazonensis promastigotes. Parasitology international. 2022 Feb; 86(?):102458. doi: 10.1016/j.parint.2021.102458. [PMID: 34509671]
  • Yang Xie, Xi Zhou, Jing Li, Xiao-Chang Yao, Wan-Li Liu, Ping-Sheng Xu, Gui-Shan Tan. Cytotoxic effects of the biflavonoids isolated from Selaginella trichoclada on MCF-7 cells and its potential mechanism. Bioorganic & medicinal chemistry letters. 2022 01; 56(?):128486. doi: 10.1016/j.bmcl.2021.128486. [PMID: 34875389]
  • Shikuo Rong, Chunrong Yang, Feng Wang, Yiyang Wu, Kuishen Sun, Tao Sun, Zeyu Wu. Amentoflavone Exerts Anti-Neuroinflammatory Effects by Inhibiting TLR4/MyD88/NF-κB and Activating Nrf2/HO-1 Pathway in Lipopolysaccharide-Induced BV2 Microglia. Mediators of inflammation. 2022; 2022(?):5184721. doi: 10.1155/2022/5184721. [PMID: 36523959]
  • Shulei Duan, Jing Fu Jia, Biao Hong, Jie Zhou, Yi Zhang, Fahuan Ge, Ming Li. Assessment of Amentoflavone Loaded Sub-Micron Particle Preparation using Supercritical Antisolvent for its Antitumor Activity. Current drug delivery. 2022; 19(1):41-48. doi: 10.2174/1567201818666210810142750. [PMID: 35135460]
  • Jia-Ling Zhuang, Ying-Yi Liu, Zhen-Zhen Li, Qi-Zhen Zhuang, Wen-Zhi Tang, Yujuan Xiong, Xian-Zhang Huang. Amentoflavone prevents ox-LDL-induced lipid accumulation by suppressing the PPARγ/CD36 signal pathway. Toxicology and applied pharmacology. 2021 11; 431(?):115733. doi: 10.1016/j.taap.2021.115733. [PMID: 34599948]
  • Hui Qiu, Zhengbing Guo, Qian Xu, Shengfang Mao, Wenming Wu. Evaluation on absorption risks of amentoflavone after oral administration in rats. Biopharmaceutics & drug disposition. 2021 Nov; 42(9):435-443. doi: 10.1002/bdd.2304. [PMID: 34655436]
  • Huan Long, Xiaolong Hu, Baolin Wang, Quan Wang, Rong Wang, Shumeng Liu, Fei Xiong, Zhenzhou Jiang, Xiao-Qi Zhang, Wen-Cai Ye, Hao Wang. Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer. Journal of medicinal chemistry. 2021 08; 64(16):12089-12108. doi: 10.1021/acs.jmedchem.1c00735. [PMID: 34404206]
  • Xiang-Ge Tian, Jian-Kun Yan, Cheng-Peng Sun, Jing-Xin Li, Jing Ning, Chao Wang, Xiao-Kui Huo, Wen-Yu Zhao, Zhen-Long Yu, Lei Feng, Xia Lv, Xiao-Chi Ma. Amentoflavone from Selaginella tamariscina as a potent inhibitor of gut bacterial β-glucuronidase: Inhibition kinetics and molecular dynamics stimulation. Chemico-biological interactions. 2021 May; 340(?):109453. doi: 10.1016/j.cbi.2021.109453. [PMID: 33785314]
  • F Qiu, L Zhang, J Zheng, L Cao, Z Zhang, Y Deng. [Amentoflavone inhibits M1 polarization of THP-1-derived foam cells by activating PPAR-α/γ]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2021 Mar; 41(3):344-351. doi: 10.12122/j.issn.1673-4254.2021.03.05. [PMID: 33849824]
  • Seona Cho, Hwa Lee, Jisu Han, Haneul Lee, Rosales Ovares Kattia, Zamora Villalobos Nelson, Sangho Choi, Soo-Yong Kim, Ho-Yong Park, Hye Gwang Jeong, Tae-Sook Jeong. Viburnum stellato-tomentosum Extract Suppresses Obesity and Hyperglycemia through Regulation of Lipid Metabolism in High-Fat Diet-Fed Mice. Molecules (Basel, Switzerland). 2021 Feb; 26(4):. doi: 10.3390/molecules26041052. [PMID: 33671428]
  • Rishab Marahatha, Saroj Basnet, Bibek Raj Bhattarai, Prakriti Budhathoki, Babita Aryal, Bikash Adhikari, Ganesh Lamichhane, Darbin Kumar Poudel, Niranjan Parajuli. Potential natural inhibitors of xanthine oxidase and HMG-CoA reductase in cholesterol regulation: in silico analysis. BMC complementary medicine and therapies. 2021 Jan; 21(1):1. doi: 10.1186/s12906-020-03162-5. [PMID: 33386071]
  • Baolin Wang, Yimeng Lu, Xiaolong Hu, Jiahao Feng, Wei Shen, Rong Wang, Hao Wang. Systematic Strategy for Metabolites of Amentoflavone In Vivo and In Vitro Based on UHPLC-Q-TOF-MS/MS Analysis. Journal of agricultural and food chemistry. 2020 Dec; 68(50):14808-14823. doi: 10.1021/acs.jafc.0c04532. [PMID: 33322906]
  • Xue Feng, Yuting Chen, Luya Li, Yuqian Zhang, Lantong Zhang, Zhiqing Zhang. Preparation, evaluation and metabolites study in rats of novel amentoflavone-loaded TPGS/soluplus mixed nanomicelles. Drug delivery. 2020 Dec; 27(1):137-150. doi: 10.1080/10717544.2019.1709920. [PMID: 31913733]
  • Lili Gan, Jiating Ma, Guoquan You, Jinxia Mai, Zhaoyu Wang, Ruopeng Yang, Cong Xie, Jingrao Fei, Lan Tang, Jie Zhao, Zheng Cai, Ling Ye. Glucuronidation and its effect on the bioactivity of amentoflavone, a biflavonoid from Ginkgo biloba leaves. The Journal of pharmacy and pharmacology. 2020 Dec; 72(12):1840-1853. doi: 10.1111/jphp.13247. [PMID: 32144952]
  • Leandro Rocha Silva, Paulo Fernando da Silva Santos-Júnior, Júlia de Andrade Brandão, Letícia Anderson, Ênio José Bassi, João Xavier de Araújo-Júnior, Sílvia Helena Cardoso, Edeildo Ferreira da Silva-Júnior. Druggable targets from coronaviruses for designing new antiviral drugs. Bioorganic & medicinal chemistry. 2020 11; 28(22):115745. doi: 10.1016/j.bmc.2020.115745. [PMID: 33007557]
  • Yan Rong, Tony K L Kiang. Characterizations of Human UDP-Glucuronosyltransferase Enzymes in the Conjugation of p-Cresol. Toxicological sciences : an official journal of the Society of Toxicology. 2020 08; 176(2):285-296. doi: 10.1093/toxsci/kfaa072. [PMID: 32421801]
  • Gye Lim Kim, Eun Hyang Jang, Da-Eun Lee, Chaeeun Bang, Haewon Kang, SooHyeon Kim, So Young Yoon, Do Hyun Lee, Jin Hee Na, Sangmin Lee, Jong-Ho Kim. Amentoflavone, active compound of Selaginella tamariscina, inhibits in vitro and in vivo TGF-β-induced metastasis of human cancer cells. Archives of biochemistry and biophysics. 2020 07; 687(?):108384. doi: 10.1016/j.abb.2020.108384. [PMID: 32343974]
  • Yan Chen, Ning Li, Haijing Wang, Ningning Wang, Hui Peng, Jing Wang, Yihong Li, Mingdi Liu, Hui Li, Yu Zhang, Zhaohui Wang. Amentoflavone suppresses cell proliferation and induces cell death through triggering autophagy-dependent ferroptosis in human glioma. Life sciences. 2020 Apr; 247(?):117425. doi: 10.1016/j.lfs.2020.117425. [PMID: 32057904]
  • Jaebok Lee, Minkyung Kim, Sang Eun Jeong, Hye Yoon Park, Che Ok Jeon, Woojun Park. Amentoflavone, a novel cyanobacterial killing agent from Selaginella tamariscina. Journal of hazardous materials. 2020 02; 384(?):121312. doi: 10.1016/j.jhazmat.2019.121312. [PMID: 31699478]
  • C Emade Kwene, Anastasie E Tih, Bintou Abderamane, Rapheal T Ghogomu. Two new phenolic glycosides from the leaves of Garcinia epunctata Stapf. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2020 Jan; 75(1-2):51-56. doi: 10.1515/znc-2018-0217. [PMID: 32053496]
  • Xinyan Qu, Qingjun Li, Xiaojuan Zhang, Zhaofen Wang, Shengqi Wang, Zhe Zhou. Amentoflavone protects the hematopoietic system of mice against γ-irradiation. Archives of pharmacal research. 2019 Nov; 42(11):1021-1029. doi: 10.1007/s12272-019-01187-0. [PMID: 31549342]
  • Luis Carrillo-Hormaza, Ana M Ramírez, Edison Osorio. Chemometric classification of Garcinia madruno raw material: Impact of the regional origin and ripeness stage of a neotropical exotic species. Food chemistry. 2019 Sep; 293(?):291-298. doi: 10.1016/j.foodchem.2019.04.118. [PMID: 31151614]
  • Chengfu Su, Chuanbin Yang, Man Gong, Yingying Ke, Peipei Yuan, Xiaolan Wang, Min Li, Xiaoke Zheng, Weisheng Feng. Antidiabetic Activity and Potential Mechanism of Amentoflavone in Diabetic Mice. Molecules (Basel, Switzerland). 2019 Jun; 24(11):. doi: 10.3390/molecules24112184. [PMID: 31212585]
  • Yulin Ren, Esperanza J Carcache de Blanco, James R Fuchs, Djaja D Soejarto, Joanna E Burdette, Steven M Swanson, A Douglas Kinghorn. Potential Anticancer Agents Characterized from Selected Tropical Plants. Journal of natural products. 2019 03; 82(3):657-679. doi: 10.1021/acs.jnatprod.9b00018. [PMID: 30830783]
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