Amentoflavone (BioDeep_00000003345)

human metabolite PANOMIX_OTCML-2023 Endogenous

代谢物信息卡片

4H-1-Benzopyran-4-one, 8-(5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-

化学式: C30H18O10 (538.0899928)
中文名称: 穗花杉双黄酮, 阿曼托黄酮
谱图信息: 最多检出来源 Viridiplantae(plant) 8.39%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(cc2=O)c1cc(c(cc1)O)c1c(cc(c2c1oc(cc2=O)c1ccc(cc1)O)O)O)O)O
InChI: InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H

描述信息

Amentoflavone is a biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-8 of the chromene ring. A natural product found particularly in Ginkgo biloba and Hypericum perforatum. It has a role as a cathepsin B inhibitor, an antiviral agent, an angiogenesis inhibitor, a P450 inhibitor and a plant metabolite. It is a biflavonoid, a hydroxyflavone and a ring assembly.
Amentoflavone is a natural product found in Podocarpus elongatus, Austrocedrus chilensis, and other organisms with data available.
A biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-8 of the chromene ring. A natural product found particularly in Ginkgo biloba and Hypericum perforatum.
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065688 - Cytochrome P-450 CYP2C9 Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065692 - Cytochrome P-450 CYP3A Inhibitors
Amentoflavone is found in fruits. Amentoflavone is obtained from Viburnum prunifolium (black haw
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase[1][2][3][4].
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase[1][2][3][4].
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase[1][2][3][4].

同义名列表

31 个代谢物同义名

数据库引用编号

21 个数据库交叉引用编号

ChEBI: CHEBI:2631
KEGG: C10018
PubChem: 5281600
HMDB: HMDB0030832
Metlin: METLIN47521
Wikipedia: Amentoflavone
LipidMAPS: LMPK12040009
MeSH: amentoflavone
ChemIDplus: 0001617534
KNApSAcK: C00042224
KNApSAcK: C00001015
foodb: FDB002788
chemspider: 4444919
CAS: 1617-53-4
CAS: 1017-53-4
medchemexpress: HY-N0662
PMhub: MS000009521
MetaboLights: MTBLC2631
PubChem: 12204
3DMET: B03462
NIKKAJI: J34.739F

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

201 个相关的物种来源信息

165205 - Afrocarpus gracilior: 10.1016/S0031-9422(00)81743-4
3813 - Albizia julibrissin: 10.1248/CPB.60.129
992639 - Allophylus decipiens: 10.1016/0305-1978(85)90066-3
89479 - Amentotaxus yunnanensis: 10.1021/NP030117B
56994 - Araucaria cunninghamii: 10.1016/S0031-9422(00)91236-6
103964 - Austrocedrus chilensis:
1898900 - Biophytum sensitivum: 10.1055/S-2006-957455
172644 - Broussonetia papyrifera: 10.1021/NP800564Z
103962 - Callitris acuminata: 10.1016/0031-9422(83)85032-8
214234 - Callitris endlicheri: 10.1016/0031-9422(83)85032-8
214231 - Callitris macleayana: 10.1016/0031-9422(83)85032-8
2250721 - Callitris neocaledonica: 10.1016/0031-9422(83)85032-8
214236 - Callitris oblonga: 10.1016/0031-9422(83)85032-8
89193 - Callitris pancheri:
214228 - Callitris pyramidalis: 10.1016/0031-9422(83)85032-8
214232 - Callitris sulcata: 10.1016/0031-9422(83)85032-8
85954 - Callitropsis nootkatensis: 10.1016/S0031-9422(00)83535-9
13387 - Calocedrus decurrens:
54798 - Calocedrus formosana:
280748 - Calophyllum brasiliense:
883767 - Calophyllum calaba: 10.1016/S0031-9422(00)80326-X
158927 - Calophyllum inophyllum:
667336 - Calophyllum venulosum:
1321791 - Campylospermum flavum: 10.1016/J.PHYTOCHEM.2010.08.006
1501027 - Campylospermum glaucum: 10.1016/J.PHYTOCHEM.2008.04.013
1321793 - Campylospermum sulcatum:
533031 - Canarium schweinfurthii: 10.4314/BCSE.V14I2.71972
66169 - Cephalotaxus fortunei: 10.1021/NP030117B
58029 - Cephalotaxus harringtonia: 10.1039/P19810001389
187461 - Chamaecyparis formosensis:
58030 - Chamaecyparis lawsoniana: 10.1016/S0031-9422(00)83535-9
187463 - Chamaecyparis thyoides: 10.1016/S0031-9422(00)83535-9
316753 - Chrozophora tinctoria:
3369 - Cryptomeria japonica: 10.1248/CPB.31.919
28977 - Cunninghamia lanceolata: 10.1248/YAKUSHI1947.88.11_1489
187464 - Cupressus cashmeriana: 10.1021/NP50051A032
13469 - Cupressus sempervirens:
329091 - Cupressus torulosa: 10.1515/ZNC-1998-11-1202
329091 - Cupressus torulosa var. torulosa: 10.1515/ZNC-1998-11-1202
1115358 - Cycas beddomei: 10.1016/S0031-9422(97)00417-2
3397 - Cycas circinalis: 10.1055/S-0029-1240743
3396 - Cycas revoluta:
13497 - Diselma archeri: 10.1016/0031-9422(83)85032-8
212299 - Elateriospermum tapos: 10.1021/NP070629G
103972 - Fitzroya cupressoides: 10.1016/0031-9422(83)85032-8
231905 - Garcinia dulcis: 10.1177/1934578X1701200337
156481 - Garcinia intermedia: 10.1248/BPB.27.141
469930 - Garcinia kola:
469932 - Garcinia livingstonei:
180114 - Garcinia prainiana: 10.1139/V10-168
198766 - Garcinia xanthochymus:
3311 - Ginkgo biloba:
3311 - Ginkgo biloba L.: -
38724 - Haplopteris anguste-elongata: 10.1021/NP050060O
290962 - Hippobromus pauciflorus: 10.1021/NP50050A061
9606 - Homo sapiens: -
268978 - Hypericum balearicum: 10.1055/S-2006-957796
1136959 - Hypericum bithynicum: 10.1055/S-2006-957796
1321328 - Hypericum elegans: 10.1080/14786410802278327
336625 - Hypericum glandulosum: 10.1055/S-2006-957796
673928 - Hypericum hirsutum: 10.1055/S-2006-960798
269006 - Hypericum maculatum:
673929 - Hypericum montanum: 10.1055/S-2006-960798
282549 - Hypericum olympicum: 10.1055/S-2006-957796
65561 - Hypericum perforatum:
626749 - Hypericum tetrapterum: 10.1055/S-2006-960798
1321357 - Hypericum thasium: 10.1016/J.PHYTOCHEM.2008.10.006
1137039 - Hypericum tomentosum: 10.1055/S-2006-957796
49752 - Isophysis tasmanica: 10.1016/S0031-9422(00)83875-3
884032 - Juniperus bermudiana: 10.1016/S0031-9422(00)83535-9
714497 - Juniperus chinensis var. chinensis: 10.1248/CPB.50.1358
58039 - Juniperus communis:
103973 - Juniperus drupacea:
758917 - Juniperus excelsa: 10.1016/S0031-9422(00)83535-9
114265 - Juniperus occidentalis: 10.1248/CPB.50.1358
69008 - Juniperus oxycedrus: 10.1016/S0031-9422(00)83535-9
61308 - Juniperus phoenicea: 10.1016/S0031-9422(00)85693-9
62753 - Juniperus procera: 10.1016/S0031-9422(00)83535-9
99809 - Juniperus rigida: 10.1248/CPB.50.1358
39584 - Juniperus virginiana:
59087 - Lanaria lanata: 10.1021/NP50075A007
52835 - Leycesteria formosa: 10.1007/978-94-015-9572-8_3
103974 - Libocedrus bidwillii: 10.1016/0031-9422(90)85105-O
2250722 - Libocedrus chevalieri: 10.1016/0031-9422(90)85105-O
13595 - Libocedrus plumosa: 10.1016/0031-9422(83)85032-8
103975 - Libocedrus yateensis:
231913 - Mammea siamensis: 10.1016/J.BMCL.2012.10.127
29780 - Mangifera indica: 10.1016/S0031-9422(00)83042-3
3983 - Manihot esculenta: 10.1016/S0031-9422(00)86949-6
3371 - Metasequoia glyptostroboides: 10.1016/S0031-9422(00)89893-3
13614 - Microbiota decussata: 10.1515/ZNC-2002-11-1208
36012 - Nageia nagi: 10.1016/S0031-9422(00)81743-4
41776 - Nandina domestica: 10.1016/S0014-2999(99)00144-2
289733 - Orthopterygium huaucui: 10.1016/0031-9422(88)80019-0
1647914 - Ouratea castaneifolia: 10.1590/S0102-695X2009000600004
2364057 - Ouratea multiflora:
2699671 - Ouratea semiserrata:
103977 - Papuacedrus papuana: 10.1016/0031-9422(83)85032-8
122947 - Patersonia glabrata: 10.1515/ZNC-1985-5-608
141000 - Physocarpus capitatus: 10.1021/NP8005259
123602 - Picea smithiana: 10.1515/ZNC-1988-1-202
103979 - Pilgerodendron uviferum: 10.1016/0031-9422(83)85032-8
46836 - Pinus palustris: 10.1007/978-94-007-4053-2_38
1639866 - Piranhea mexicana:
33090 - Plants: -
58046 - Platycladus orientalis:
58046 - Platycladus orientalis (L.) Franco: -
1030195 - Podocarpus elongatus: 10.1016/S0031-9422(00)81743-4
120615 - Podocarpus fasciculus: 10.1248/CPB.56.585
120620 - Podocarpus latifolius: 10.1016/S0031-9422(00)81743-4
58043 - Podocarpus macrophyllus: 10.1248/CPB.28.1894
61307 - Podocarpus neriifolius:
120625 - Podocarpus nivalis: 10.1248/CPB.56.585
485824 - Prumnopitys montana: 10.1016/S0031-9422(00)81743-4
2029322 - Psilotum complanatum: 10.1016/0305-1978(90)90024-A
3240 - Psilotum nudum: 10.1016/0305-1978(90)90024-A
568684 - Quercus canariensis: 10.1007/978-94-007-4053-2_3
39470 - Quercus infectoria: 10.1007/978-94-007-4053-2_3
39471 - Quercus pubescens: 10.1007/978-94-007-4053-2_3
190404 - Retrophyllum rospigliosii: 10.1055/S-2007-990218
298661 - Rhus coriaria: 10.1007/BF02311521
298665 - Rhus punjabensis: 10.1007/S10600-015-1336-2
270266 - Schinus areira: 10.1016/0305-1978(85)90066-3
169191 - Schinus terebinthifolia: 10.1515/ZNB-1986-1125
28979 - Sciadopitys verticillata: 10.1515/ZNC-1998-11-1202
298681 - Searsia quartiniana: 10.1016/0305-1978(85)90066-3
289761 - Searsia undulata: 10.1016/0305-1978(85)90066-3
1353958 - Selaginella braunii:
417315 - Selaginella davidii:
1353961 - Selaginella delicatula:
50508 - Selaginella denticulata: 10.1515/ZNC-1994-3-417
186426 - Selaginella doederleinii:
186426 - Selaginella Doederleinii Hieron: -
81964 - Selaginella kraussiana: 10.1007/978-1-4615-3476-1_53
1353966 - Selaginella labordei: 10.1080/14786410802228736
88036 - Selaginella moellendorffii:
1715386 - Selaginella nothohybrida: 10.1016/J.JEP.2015.01.031
672198 - Selaginella pulvinata:
493175 - Selaginella sanguinolenta:
69996 - Selaginella selaginoides: 10.1515/ZNC-1994-3-416
137174 - Selaginella sinensis:
137175 - Selaginella stauntoniana:
137178 - Selaginella tamariscina:
307165 - Selaginella uncinata:
137179 - Selaginella willdenowii: 10.1016/0031-9422(95)00212-P
99814 - Sequoiadendron giganteum: 10.1515/ZNC-1998-11-1202
50187 - Taiwania cryptomerioides: 10.1039/P19810000553
28982 - Taxodium distichum: 10.1016/0031-9422(73)80042-1
25629 - Taxus baccata:
99806 - Taxus cuspidata: 10.1515/ZNC-1998-11-1202
147273 - Taxus wallichiana:
13717 - Tetraclinis articulata: 10.1016/0031-9422(83)85032-8
241616 - Thuja koraiensis: 10.1016/S0031-9422(00)83535-9
3317 - Thuja occidentalis: 10.1016/S0031-9422(00)83535-9
3316 - Thuja plicata:
89194 - Thuja standishii: 10.1016/S0031-9422(00)83535-9
13727 - Thujopsis dolabrata: 10.1016/S0031-9422(00)83535-9
121718 - Tilia tomentosa: 10.1016/0378-8741(94)90098-1
147460 - Torreya fargesii var. yunnanensis: 10.1021/NP030117B
58047 - Torreya grandis: 10.1021/NP030117B
50189 - Torreya nucifera:
269721 - Toxicodendron succedaneum:
269721 - Toxicodendron succedaneum [Syn. Rhus succedanea ]: -
226819 - Trogopterus xanthipes: 10.1080/14786419.2010.482057
224736 - Viburnum betulifolium: 10.1016/S0031-9422(98)00681-5
1190426 - Viburnum buddleifolium: 10.1016/S0031-9422(98)00681-5
1190427 - Viburnum burejaeticum: 10.1016/S0031-9422(98)00681-5
237927 - Viburnum carlesii: 10.1016/S0031-9422(98)00681-5
237928 - Viburnum cinnamomifolium: 10.1016/S0031-9422(98)00681-5
1127644 - Viburnum coriaceum: 10.1016/S0031-9422(00)82372-9
446156 - Viburnum cotinifolium:
237931 - Viburnum cylindricum:
237932 - Viburnum davidii: 10.1016/S0031-9422(98)00681-5
61589 - Viburnum dentatum: 10.1016/S0031-9422(98)00681-5
237939 - Viburnum farreri: 10.1016/S0031-9422(98)00681-5
1444319 - Viburnum foetens: 10.1016/S0031-9422(98)00681-5
1190434 - Viburnum glomeratum: 10.1016/S0031-9422(98)00681-5
1444320 - Viburnum grandiflorum: 10.1016/S0031-9422(98)00681-5
1444321 - Viburnum henryi: 10.1016/S0031-9422(98)00681-5
237943 - Viburnum jucundum: 10.1055/S-2001-17357
237945 - Viburnum lantana: 10.1016/S0031-9422(98)00681-5
61590 - Viburnum lentago: 10.1016/S0031-9422(98)00681-5
237950 - Viburnum nudum: 10.1016/S0031-9422(98)00681-5
237951 - Viburnum odoratissimum: 10.1016/S0031-9422(98)00681-5
85293 - Viburnum opulus:
432678 - Viburnum orientale: 10.1016/S0031-9422(98)00681-5
1190442 - Viburnum pichinchense: 10.1016/S0305-1978(02)00078-9
179996 - Viburnum plicatum: 10.1016/S0031-9422(98)00681-5
432679 - Viburnum propinquum: 10.1016/S0031-9422(98)00681-5
237954 - Viburnum prunifolium: 10.1016/S0031-9422(98)00681-5
47689 - Viburnum rhytidophyllum: 10.1016/S0031-9422(98)00681-5
436501 - Viburnum setigerum: 10.1016/S0031-9422(98)00681-5
61591 - Viburnum sieboldii: 10.1016/S0031-9422(98)00681-5
237958 - Viburnum suspensum: 10.1016/S0031-9422(98)00681-5
237959 - Viburnum tinus: 10.1016/S0031-9422(98)00681-5
237963 - Viburnum utile: 10.1016/S0031-9422(98)00681-5
13760 - Widdringtonia cedarbergensis: 10.1016/0031-9422(83)85032-8
214229 - Widdringtonia nodiflora: 10.1016/0031-9422(83)85032-8
1075059 - Widdringtonia whytei: 10.1016/0031-9422(83)85032-8
58046 - 侧柏叶: -
33090 - 卷柏: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Chie Aoki-Utsubo, Puguh Indrasetiawan, Kento Fukano, Masamichi Muramatsu, Nina Artanti, Muhammad Hanafi, Hak Hotta, Masanori Kameoka. Amentoflavone inhibits hepatitis B virus infection via the suppression of preS1 binding to host cells. Microbiology and immunology. 2023 Mar; ?(?):. doi: 10.1111/1348-0421.13064. [PMID: 36929353]
Hardeep Singh Tuli, Hemant Joshi, Kanupriya Vashishth, Seema Ramniwas, Mehmet Varol, Manoj Kumar, Isha Rani, Vibha Rani, Katrin Sak. Chemopreventive mechanisms of amentoflavone: recent trends and advancements. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Feb; ?(?):. doi: 10.1007/s00210-023-02416-6. [PMID: 36773053]
Wang Tingting, Fang Tianqi, Wang Xinyu, Zhang Can, Shen Xue, Deng Xuming, Wang Jianfeng. Amentoflavone attenuates Listeria monocytogenes pathogenicity through an LLO-dependent mechanism. British journal of pharmacology. 2022 07; 179(14):3839-3858. doi: 10.1111/bph.15827. [PMID: 35229287]
Dipta Dey, Rajib Hossain, Partha Biswas, Priyanka Paul, Md Aminul Islam, Tanzila Ismail Ema, Bibhuti Kumar Gain, Mohammad Mehedi Hasan, Shabana Bibi, Muhammad Torequl Islam, Md Ataur Rahman, Bonglee Kim. Amentoflavone derivatives significantly act towards the main protease (3CLPRO/MPRO) of SARS-CoV-2: in silico admet profiling, molecular docking, molecular dynamics simulation, network pharmacology. Molecular diversity. 2022 May; ?(?):. doi: 10.1007/s11030-022-10459-9. [PMID: 35639226]
Qi Sun, Peng Zhen, Dandan Li, Xiaochen Liu, Xinling Ding, Huihui Liu. Amentoflavone promotes ferroptosis by regulating reactive oxygen species (ROS) /5'AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) to inhibit the malignant progression of endometrial carcinoma cells. Bioengineered. 2022 05; 13(5):13269-13279. doi: 10.1080/21655979.2022.2079256. [PMID: 35635082]
Chun-Yu Li, Hao-Nan Wang, Rong-Jing He, Jian Huang, Li-Lin Song, Yun-Qing Song, Peng-Chao Huo, Jie Hou, Guang Ji, Guang-Bo Ge. Discovery and characterization of amentoflavone as a naturally occurring inhibitor against the bile salt hydrolase produced by Lactobacillus salivarius. Food & function. 2022 Mar; 13(6):3318-3328. doi: 10.1039/d1fo03277a. [PMID: 35257124]
Yasmin Silva Rizk, Daiana de Jesus Hardoim, Kaique Bertrand Almeida Santos, Tânia Zaverucha-do-Valle, Noemi Nosomi Taniwaki, Fernando Almeida-Souza, Carlos Alexandre Carollo, Marcos André Vannier-Santos, Carla Cardozo Pinto de Arruda, Kátia da Silva Calabrese. Amentoflavone isolated from Selaginella sellowii Hieron induces mitochondrial dysfunction in Leishmania amazonensis promastigotes. Parasitology international. 2022 Feb; 86(?):102458. doi: 10.1016/j.parint.2021.102458. [PMID: 34509671]
Yang Xie, Xi Zhou, Jing Li, Xiao-Chang Yao, Wan-Li Liu, Ping-Sheng Xu, Gui-Shan Tan. Cytotoxic effects of the biflavonoids isolated from Selaginella trichoclada on MCF-7 cells and its potential mechanism. Bioorganic & medicinal chemistry letters. 2022 01; 56(?):128486. doi: 10.1016/j.bmcl.2021.128486. [PMID: 34875389]
Shikuo Rong, Chunrong Yang, Feng Wang, Yiyang Wu, Kuishen Sun, Tao Sun, Zeyu Wu. Amentoflavone Exerts Anti-Neuroinflammatory Effects by Inhibiting TLR4/MyD88/NF-κB and Activating Nrf2/HO-1 Pathway in Lipopolysaccharide-Induced BV2 Microglia. Mediators of inflammation. 2022; 2022(?):5184721. doi: 10.1155/2022/5184721. [PMID: 36523959]
Shulei Duan, Jing Fu Jia, Biao Hong, Jie Zhou, Yi Zhang, Fahuan Ge, Ming Li. Assessment of Amentoflavone Loaded Sub-Micron Particle Preparation using Supercritical Antisolvent for its Antitumor Activity. Current drug delivery. 2022; 19(1):41-48. doi: 10.2174/1567201818666210810142750. [PMID: 35135460]
Jia-Ling Zhuang, Ying-Yi Liu, Zhen-Zhen Li, Qi-Zhen Zhuang, Wen-Zhi Tang, Yujuan Xiong, Xian-Zhang Huang. Amentoflavone prevents ox-LDL-induced lipid accumulation by suppressing the PPARγ/CD36 signal pathway. Toxicology and applied pharmacology. 2021 11; 431(?):115733. doi: 10.1016/j.taap.2021.115733. [PMID: 34599948]
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Huan Long, Xiaolong Hu, Baolin Wang, Quan Wang, Rong Wang, Shumeng Liu, Fei Xiong, Zhenzhou Jiang, Xiao-Qi Zhang, Wen-Cai Ye, Hao Wang. Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer. Journal of medicinal chemistry. 2021 08; 64(16):12089-12108. doi: 10.1021/acs.jmedchem.1c00735. [PMID: 34404206]
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