Genistein (BioDeep_00000000259)

 

Secondary id: BioDeep_00000397994, BioDeep_00000859693

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


Genistein, Pharmaceutical Secondary Standard; Certified Reference Material

化学式: C15H10O5 (270.052821)
中文名称: 金雀异黄酮, 染料木素, 染料木黄酮
谱图信息: 最多检出来源 Viridiplantae(plant) 1.39%

分子结构信息

SMILES: c1(cc(c2c(c1)occ(c2=O)c1ccc(cc1)O)O)O
InChI: InChI=1/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H

描述信息

Genistein is a 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4. It is a phytoestrogenic isoflavone with antioxidant properties. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, a phytoestrogen, a plant metabolite, a geroprotector and a human urinary metabolite. It is a conjugate acid of a genistein(1-).
An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines. Additionally, genistein has antihelmintic activity. It has been determined to be the active ingredient in Felmingia vestita, which is a plant traditionally used against worms. It has shown to be effective in the treatment of common liver fluke, pork trematode and poultry cestode. Further, genistein is a phytoestrogen which has selective estrogen receptor modulator properties. It has been investigated in clinical trials as an alternative to classical hormone therapy to help prevent cardiovascular disease in postmenopausal women. Natural sources of genistein include tofu, fava beans, soybeans, kudzu, and lupin.
Genistein is a natural product found in Pterocarpus indicus, Ficus septica, and other organisms with data available.
Genistein is a soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. (NCI04)
Genistein is one of several known isoflavones. Isoflavones compounds, such as genistein and daidzein, are found in a number of plants, but soybeans and soy products like tofu and textured vegetable protein are the primary food source. Genistein is a natural bioactive compound derived from legumes and has drawn because of its potentially beneficial effects on some human degenerative diseases. It has a weak estrogenic effect and is a well-known non-specific tyrosine kinase inhibitor at pharmacological doses. Epidemiological studies show that genistein intake is inversely associated with the risk of cardiovascular diseases. Data suggests a protective role of genistein in cardiovascular events. However, the mechanisms of the genistein action on vascular protective effects are unclear. Past extensive studies exploring its hypolipidemic effect resulted in contradictory data. Genistein also is a relatively poor antioxidant. However, genistein protects against pro-inflammatory factor-induced vascular endothelial barrier dysfunction and inhibits leukocyte-endothelium interaction, thereby modulating vascular inflammation, a major event in the pathogenesis of atherosclerosis. Genistein exerts a non-genomic action by targeting on important signaling molecules in vascular endothelial cells (ECs). Genistein rapidly activates endothelial nitric oxide synthase and production of nitric oxide in ECs. This genistein effect is novel since it is independent of its known effects, but mediated by the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) cascade. Genistein directly stimulates the plasma membrane-associated adenylate cyclases, leading to activation of the cAMP signaling pathway. In addition, genistein activates peroxisome proliferator-activated receptors, ligand-activated nuclear receptors important to normal vascular function. Furthermore, genistein reduces reactive oxygen species (ROS) by attenuating the expression of ROS-producing enzymes. These findings reveal the roles for genistein in the regulation of vascular function and provide a basis for further investigating its therapeutic potential f...
Genistein is one of several known isoflavones. Isoflavones compounds, such as genistein and daidzein, are found in a number of plants, but soybeans and soy products like tofu and textured vegetable protein are the primary food source. Genistein is a natural bioactive compound derived from legumes and has drawn because of its potentially beneficial effects on some human degenerative diseases. It has a weak estrogenic effect and is a well-known non-specific tyrosine kinase inhibitor at pharmacological doses. Epidemiological studies show that genistein intake is inversely associated with the risk of cardiovascular diseases. Data suggests a protective role of genistein in cardiovascular events. However, the mechanisms of the genistein action on vascular protective effects are unclear. Past extensive studies exploring its hypolipidemic effect resulted in contradictory data. Genistein also is a relatively poor antioxidant. However, genistein protects against pro-inflammatory factor-induced vascular endothelial barrier dysfunction and inhibits leukocyte-endothelium interaction, thereby modulating vascular inflammation, a major event in the pathogenesis of atherosclerosis. Genistein exerts a non-genomic action by targeting on important signaling molecules in vascular endothelial cells (ECs). Genistein rapidly activates endothelial nitric oxide synthase and production of nitric oxide in ECs. This genistein effect is novel since it is independent of its known effects, but mediated by the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) cascade. Genistein directly stimulates the plasma membrane-associated adenylate cyclases, leading to activation of the cAMP signaling pathway. In addition, genistein activates peroxisome proliferator-activated receptors, ligand-activated nuclear receptors important to normal vascular function. Furthermore, genistein reduces reactive oxygen species (ROS) by attenuating the expression of ROS-producing enzymes. These findings reveal the roles for genistein in the regulation of vascular function and provide a basis for further investigating its therapeutic potential for inflammatory-related vascular disease. (PMID:17979711). Genistein is a biomarker for the consumption of soy beans and other soy products.
Genistein is a phenolic compound belonging to the isoflavonoid group. Isoflavonoids are found mainly in soybean. Genistein and daidzein (an other isoflavonoid) represent the major phytochemicals found in this plant. Health benefits (e.g. reduced risk for certain cancers and diseases of old age) associated to soya products consumption have been observed in East Asian populations and several epidemiological studies. This association has been linked to the action of isoflavonoids. With a chemical structure similar to the hormone 17-b-estradiol, soy isoflavones are able to interact with the estrogen receptor. They also possess numerous biological activities. (PMID: 15540649). Genistein is a biomarker for the consumption of soy beans and other soy products.
A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4. It is a phytoestrogenic isoflavone with antioxidant properties.
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1821 - Selective Estrogen Receptor Modulator
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
D020011 - Protective Agents > D016588 - Anticarcinogenic Agents
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
D000970 - Antineoplastic Agents
C1892 - Chemopreventive Agent
CONFIDENCE standard compound; INTERNAL_ID 765; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5085; ORIGINAL_PRECURSOR_SCAN_NO 5082
CONFIDENCE standard compound; INTERNAL_ID 765; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8554; ORIGINAL_PRECURSOR_SCAN_NO 8550
CONFIDENCE standard compound; INTERNAL_ID 765; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5097; ORIGINAL_PRECURSOR_SCAN_NO 5094
ORIGINAL_ACQUISITION_NO 5097; CONFIDENCE standard compound; INTERNAL_ID 765; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_PRECURSOR_SCAN_NO 5094
CONFIDENCE standard compound; INTERNAL_ID 765; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5104; ORIGINAL_PRECURSOR_SCAN_NO 5099
CONFIDENCE standard compound; INTERNAL_ID 765; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8558; ORIGINAL_PRECURSOR_SCAN_NO 8556
CONFIDENCE standard compound; INTERNAL_ID 765; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5082; ORIGINAL_PRECURSOR_SCAN_NO 5079
CONFIDENCE standard compound; INTERNAL_ID 765; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8540; ORIGINAL_PRECURSOR_SCAN_NO 8539
CONFIDENCE standard compound; INTERNAL_ID 765; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8556; ORIGINAL_PRECURSOR_SCAN_NO 8554
CONFIDENCE standard compound; INTERNAL_ID 765; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8561; ORIGINAL_PRECURSOR_SCAN_NO 8559
CONFIDENCE standard compound; INTERNAL_ID 765; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5096; ORIGINAL_PRECURSOR_SCAN_NO 5093
CONFIDENCE standard compound; INTERNAL_ID 765; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8572; ORIGINAL_PRECURSOR_SCAN_NO 8570
CONFIDENCE standard compound; INTERNAL_ID 765; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5090; ORIGINAL_PRECURSOR_SCAN_NO 5089
CONFIDENCE Reference Standard (Level 1); NaToxAq - Natural Toxins and Drinking Water Quality - From Source to Tap (https://natoxaq.ku.dk)
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3265
IPB_RECORD: 441; CONFIDENCE confident structure
CONFIDENCE standard compound; INTERNAL_ID 4238
CONFIDENCE standard compound; INTERNAL_ID 8827
CONFIDENCE standard compound; INTERNAL_ID 2419
CONFIDENCE standard compound; INTERNAL_ID 4162
CONFIDENCE standard compound; INTERNAL_ID 176
Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.
Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.

同义名列表

96 个代谢物同义名

Genistein, Pharmaceutical Secondary Standard; Certified Reference Material; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-(ChemID); Genistein, United States Pharmacopeia (USP) Reference Standard; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4 H-1-benzopyran-4-one; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one,7-dihydroxy-3-(4-hydroxyphenyl)-; 5,7-dihydroxy-3-(4-hydroxyphenyl)-1-benzopyran-4-one; Genistein, primary pharmaceutical reference standard; Genistein, from Glycine max (soybean), ~98\\% (HPLC); 3-(4-hydroxyphenyl)-5,7-bis(oxidanyl)chromen-4-one; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; GENISTEIN (CONSTITUENT OF SOY ISOFLAVONES) [DSC]; 5,7-dihydroxy-3-(4-hydroxyphenyl)-chromen-4-one; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone; 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one; 5-18-04-00594 (Beilstein Handbook Reference); Genistein, synthetic, >=98\\% (HPLC), powder; GENISTEIN (CONSTITUENT OF RED CLOVER) [DSC]; GENISTEIN (CONSTITUENT OF SOY ISOFLAVONES); GENISTEIN (CONSTITUENT OF RED CLOVER); Genistein; 4,5,7-Trihydroxyisoflavone; Genistein, analytical standard; ISOFLAVONE, 4,5,7-TRIHYDROXY-; 4,5,7-Trihydroxy Iso-Flavone; 4,5, 7-Trihydroxyisoflavone; 4,5,7-trihydroxy-Isoflavone; 5,7,4-Trihydroxyisoflavone; Isoflavone,5,7-trihydroxy-; 4,5,7-Trihydroxyisoflavone; 4,7-Trihydroxyisoflavone; TEMPO HOT FLASH RELIEF; Lactoferrin-genistein; Genistein (Standard); Genistein 85\\% HPLC; GENISTEIN [WHO-DD]; GENISTEIN [USP-RS]; GENISTEIN (USP-RS); GENISTEIN [MART.]; GENISTEIN (MART.); Genistein [USAN]; Spectrum5_000106; GENISTEIN [INCI]; GENISTEIN [HSDB]; Genistein (USAN); Spectrum4_001543; Spectrum2_000638; Spectrum3_000678; Genistein (GEN); UNII-DH2M523P0H; GENISTEIN [INN]; GENISTEIN [MI]; Tox21_110161_1; DivK1c_006401; MEGxp0_000568; Oprea1_224620; Genistein,(S); Lopac0_000520; Oprea1_437815; Differenol A; KBio2_003368; KBio2_002564; KBio3_003042; KBio1_001345; Tox21_110161; ACon1_001065; KBio2_007700; KBio3_001595; NCI60_003369; KBio2_005936; Tox21_201428; Tox21_500520; Tox21_300585; KBio2_000800; KBio2_005132; Genistein, 8; Bio1_000445; Bio1_000934; Bio1_001423; SMP1_000133; Sophoricol; Genisterin; DH2M523P0H; Genisteol; Genestein; Bonistein; Genistein; CHEMBL44; Prunetol; 3kgt; 1x7r; 2qa8; 3kgu; GEN; 4 5 7-trihydroxyisoflavone; NPI 031L



数据库引用编号

108 个数据库交叉引用编号

分类词条

相关代谢途径

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BioCyc(0)

PlantCyc(0)

代谢反应

235 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(235)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

484 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Gaoxuan Shao, Ying Liu, Lu Lu, Lei Wang, Guang Ji, Hanchen Xu. Therapeutic potential of traditional Chinese medicine in the prevention and treatment of digestive inflammatory cancer transformation: Portulaca oleracea L. as a promising drug. Journal of ethnopharmacology. 2024 Jun; 327(?):117999. doi: 10.1016/j.jep.2024.117999. [PMID: 38447616]
  • Palash Mandal, David A Mortensen, André F Brito, Anna K Wallingford, Marta R M Lima, Nicholas D Warren, Richard G Smith. Water Stress Influences Phytoestrogen Levels in Red Clover (Trifolium pratense) but Not Kura Clover (T. ambiguum). Journal of agricultural and food chemistry. 2024 May; 72(18):10247-10256. doi: 10.1021/acs.jafc.4c00300. [PMID: 38683760]
  • Xue Li, Le Liu, Mei-Xuan Wan, Li-Min Gong, Juan Su, Li Xu. Active Components of Pueraria lobata through the MAPK/ERK Signaling Pathway Alleviate Iron Overload in Alcoholic Liver Disease. Chemistry & biodiversity. 2024 May; 21(5):e202400005. doi: 10.1002/cbdv.202400005. [PMID: 38504590]
  • Yaning Wu, Hongwei Zhang, Jianguang Zhu, Zhenling Zhang, Songbo Ma, Yongqi Zhao, Yiming Wang, Jun Yuan, Xing Guo, Yajing Li, Shuai Zhang. The Effect of Fermentation on the Chemical Constituents of Gastrodia Tuber Hallimasch Powder (GTHP) Estimated by UHPLC-Q-Orbitrap HRMS and HPLC. Molecules (Basel, Switzerland). 2024 Apr; 29(7):. doi: 10.3390/molecules29071663. [PMID: 38611942]
  • Yun Bo Zhang, Jiang Li Li, Jie Tian, Xiao Lin Na. Effect of Maternal DEHP Exposure on Lipid Metabolism in Adult Male Rats and the Antagonistic Effect of Genistein. Biomedical and environmental sciences : BES. 2024 Mar; 37(3):315-319. doi: 10.3967/bes2024.034. [PMID: 38582995]
  • Jamie Gudyka, Jasmin Ceja-Vega, Katherine Ivanchenko, Wilber Perla, Christopher Poust, Alondra Gamez Hernandez, Colleen Clarke, Shakinah Silverberg, Escarlin Perez, Sunghee Lee. Differential Effects of Soy Isoflavones on the Biophysical Properties of Model Membranes. The journal of physical chemistry. B. 2024 Mar; 128(10):2412-2424. doi: 10.1021/acs.jpcb.3c08390. [PMID: 38417149]
  • Magdalena Wójciak, Piotr Drozdowski, Aleksandra Ziemlewska, Martyna Zagórska-Dziok, Zofia Nizioł-Łukaszewska, Tomasz Kubrak, Ireneusz Sowa. ROS Scavenging Effect of Selected Isoflavones in Provoked Oxidative Stress Conditions in Human Skin Fibroblasts and Keratinocytes. Molecules (Basel, Switzerland). 2024 Feb; 29(5):. doi: 10.3390/molecules29050955. [PMID: 38474467]
  • Nopawit Khamto, Kraikrit Utama, Panida Boontawee, Atchara Janthong, Suriya Tatieng, Supakorn Arthan, Vachira Choommongkol, Padchanee Sangthong, Chavi Yenjai, Nuttee Suree, Puttinan Meepowpan. Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CLpro: Insights from the Computational and Experimental Investigations. Journal of chemical information and modeling. 2024 Jan; ?(?):. doi: 10.1021/acs.jcim.3c01477. [PMID: 38277124]
  • Eman Shawky, Rasha A Nassra, Aliaa M T El-Alkamy, Shaimaa M Sallam, Samah M El Sohafy. Unraveling the mechanisms of Fenugreek seed for managing different gynecological disorders: steroidal saponins and isoflavones revealed as key bioactive metabolites. Journal of pharmaceutical and biomedical analysis. 2024 Jan; 238(?):115865. doi: 10.1016/j.jpba.2023.115865. [PMID: 38000191]
  • Ida K L Andersen, Inge S Fomsgaard, Jim Rasmussen. Intercropping of Narrow-Leafed Lupin (Lupinus angustifolius L.) and Barley (Hordeum vulgare L.) Affects the Flavonoid Composition of Both Crops. Journal of agricultural and food chemistry. 2024 Jan; 72(1):108-115. doi: 10.1021/acs.jafc.3c03684. [PMID: 38146912]
  • Canhong Wang, Bao Gong, Yulan Wu, Congwen Bai, Meihua Yang, Xiangsheng Zhao, Jianhe Wei. Pharmacokinetics and molecular docking of the cardioprotective flavonoids in Dalbergia odorifera. Journal of separation science. 2024 Jan; 47(1):e2300614. doi: 10.1002/jssc.202300614. [PMID: 38066409]
  • Longlong Li, Ze Lu, Yulei Wang, Ying Yang, Huihui Wang, Haitian Ma. Genistein alleviates chronic heat stress-induced lipid metabolism disorder and mitochondrial energetic dysfunction by activating the GPR30-AMPK-PGC-1α signaling pathways in the livers of broiler chickens. Poultry science. 2024 Jan; 103(1):103251. doi: 10.1016/j.psj.2023.103251. [PMID: 37984004]
  • Yilin Chen, Fengwei Zhang, Jijia Sun, Lei Zhang. Identifying the natural products in the treatment of atherosclerosis by increasing HDL-C level based on bioinformatics analysis, molecular docking, and in vitro experiment. Journal of translational medicine. 2023 Dec; 21(1):920. doi: 10.1186/s12967-023-04755-7. [PMID: 38115108]
  • Worapol Sae-Foo, Sukritta Singkham, Pimsiri Srisongkhram, Gorawit Yusakul, Pisitchai Masugarut, Waraporn Putalun. Development and characterisation of highly specific monoclonal antibody-based immunoassays for the detection and quantification of genistein-7-O-[α-rhamnopyranosyl-(1→6)]-β-glucopyranoside in Derris scandens (Roxb.) Benth. Phytochemical analysis : PCA. 2023 Nov; ?(?):. doi: 10.1002/pca.3305. [PMID: 37965872]
  • Haruna Nagayoshi, Norie Murayama, Vitchan Kim, Donghak Kim, Shigeo Takenaka, Hiroshi Yamazaki, F Peter Guengerich, Tsutomu Shimada. Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1. Chemical research in toxicology. 2023 Oct; ?(?):. doi: 10.1021/acs.chemrestox.3c00229. [PMID: 37783573]
  • Tong Xuan, Yuhan Liu, Rui Liu, Sheng Liu, Jiaqi Han, Xinyu Bai, Jie Wu, Ronghua Fan. Advances in Extraction, Purification, and Analysis Techniques of the Main Components of Kudzu Root: A Comprehensive Review. Molecules (Basel, Switzerland). 2023 Sep; 28(18):. doi: 10.3390/molecules28186577. [PMID: 37764353]
  • Shun Watanabe, Riki Haruyama, Koji Umezawa, Ikuo Tomioka, Soichiro Nakamura, Shigeru Katayama, Takakazu Mitani. Genistein enhances NAD+ biosynthesis by upregulating nicotinamide phosphoribosyltransferase in adipocytes. The Journal of nutritional biochemistry. 2023 Aug; 121(?):109433. doi: 10.1016/j.jnutbio.2023.109433. [PMID: 37648097]
  • Yaoyao Ren, Shengtao Qu. Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: Evidence from preclinical studies. Ageing research reviews. 2023 Aug; 90(?):102040. doi: 10.1016/j.arr.2023.102040. [PMID: 37619620]
  • Yi Wei, Yongfa Liu, Guang Li, Yuming Guo, Bingkun Zhang. Effects of quercetin and genistein on egg quality, lipid profiles and immunity in laying hens. Journal of the science of food and agriculture. 2023 Aug; ?(?):. doi: 10.1002/jsfa.12910. [PMID: 37552763]
  • Gabriella Magarelli, Cínthia Caetano Bonatto, Gabriela Mendes da Rocha Vaz, Victoria Baggi Mendonça Lauria, Luciano Paulino Silva. Unveiling the Remarkable Antioxidant Activity of Plant-Based Fish and Seafood Analogs through Electrochemical Sensor Analysis. Biosensors. 2023 Jul; 13(7):. doi: 10.3390/bios13070751. [PMID: 37504149]
  • Fei Teng, Zhongwen Lu, Fei Gao, Jing Liang, Jiawen Li, Xuanhe Tian, Xianshuai Wang, Haowei Guan, Jin Wang. Systems biology approaches to identify potential targets and inhibitors of the intestinal microbiota to treat depression. Scientific reports. 2023 07; 13(1):11225. doi: 10.1038/s41598-023-38444-8. [PMID: 37433869]
  • Ana Ruiz de la Bastida, Susana Langa, Ángela Peirotén, Raúl Fernández-Gonzalez, Abel Sánchez-Jiménez, María Maroto, José Antonio Curiel, Eva Guillamon, Juan Luis Arqués, Alfonso Gutiérrez-Adán, José María Landete. Effect of fermented soy beverage in aged female mice model. Food research international (Ottawa, Ont.). 2023 07; 169(?):112745. doi: 10.1016/j.foodres.2023.112745. [PMID: 37254374]
  • Iskandar Azmy Harahap, Maciej Kuligowski, Marcin Schmidt, Joanna Suliburska. The impact of soy products, isoflavones, and Lactobacillus acidophilus on iron status and morphological parameters in healthy female rats. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2023 Jul; 78(?):127183. doi: 10.1016/j.jtemb.2023.127183. [PMID: 37120971]
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