Fumaric acid (BioDeep_00000000321)

 

Secondary id: BioDeep_00000400095, BioDeep_00000405208

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


(2E)-but-2-enedioic acid

化学式: C4H4O4 (116.0109584)
中文名称: 反丁烯二酸, 富马酸, 延胡索酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.05%

Reviewed

Last reviewed on 2024-07-01.

Cite this Page

Fumaric acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/fumaric_acid (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000000321). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(=CC(=O)O)C(=O)O
InChI: InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+

描述信息

Fumaric acid appears as a colorless crystalline solid. The primary hazard is the threat to the environment. Immediate steps should be taken to limit spread to the environment. Combustible, though may be difficult to ignite. Used to make paints and plastics, in food processing and preservation, and for other uses.
Fumaric acid is a butenedioic acid in which the C=C double bond has E geometry. It is an intermediate metabolite in the citric acid cycle. It has a role as a food acidity regulator, a fundamental metabolite and a geroprotector. It is a conjugate acid of a fumarate(1-).
Fumaric acid is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
Fumaric acid is a precursor to L-malate in the Krebs tricarboxylic acid cycle. It is formed by the oxidation of succinate by succinate dehydrogenase. Fumarate is converted by fumarase to malate. A fumarate is a salt or ester of the organic compound fumaric acid, a dicarboxylic acid. Fumarate has recently been recognized as an oncometabolite. (A15199). As a food additive, fumaric acid is used to impart a tart taste to processed foods. It is also used as an antifungal agent in boxed foods such as cake mixes and flours, as well as tortillas. Fumaric acid is also added to bread to increase the porosity of the final baked product. It is used to impart a sour taste to sourdough and rye bread. In cake mixes, it is used to maintain a low pH and prevent clumping of the flours used in the mix. In fruit drinks, fumaric acid is used to maintain a low pH which, in turn, helps to stabilize flavor and color. Fumaric acid also prevents the growth of E. coli in beverages when used in combination with sodium benzoate. When added to wines, fumaric acid helps to prevent further fermentation and yet maintain low pH and eliminate traces of metallic elements. In this fashion, it helps to stabilize the taste of wine. Fumaric acid can also be added to dairy products, sports drinks, jams, jellies and candies. Fumaric acid helps to break down bonds between gluten proteins in wheat and helps to create a more pliable dough. Fumaric acid is used in paper sizing, printer toner, and polyester resin for making molded walls.
Fumaric acid is a dicarboxylic acid. It is a precursor to L-malate in the Krebs tricarboxylic acid (TCA) cycle. It is formed by the oxidation of succinic acid by succinate dehydrogenase. Fumarate is converted by the enzyme fumarase to malate. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears to due to its ability to inhibit prolyl hydroxylase-containing enzymes. In many tumours, oxygen availability becomes limited (hypoxia) very quickly due to rapid cell proliferation and limited blood vessel growth. The major regulator of the response to hypoxia is the HIF transcription factor (HIF-alpha). Under normal oxygen levels, protein levels of HIF-alpha are very low due to constant degradation, mediated by a series of post-translational modification events catalyzed by the prolyl hydroxylase domain-containing enzymes PHD1, 2 and 3, (also known as EglN2, 1 and 3) that hydroxylate HIF-alpha and lead to its degradation. All three of the PHD enzymes are inhibited by fumarate. Fumaric acid is found to be associated with fumarase deficiency, which is an inborn error of metabolism. It is also a metabolite of Aspergillus.
Produced industrially by fermentation of Rhizopus nigricans, or manufactured by catalytic or thermal isomerisation of maleic anhydride or maleic acid. Used as an antioxidant, acidulant, leavening agent and flavouring agent in foods. Present in raw lean fish. Dietary supplement. Used in powdered products since fumaric acid is less hygroscopic than other acids. A precursor to L-malate in the Krebs tricarboxylic acid cycle. It is formed by the oxidation of succinate by succinate dehydrogenase (wikipedia). Fumaric acid is also found in garden tomato, papaya, wild celery, and star fruit.

Fumaric acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=110-17-8 (retrieved 2024-07-01) (CAS RN: 110-17-8). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite.
Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite.

同义名列表

134 个代谢物同义名

Fumaric Acid, Pharmaceutical Secondary Standard; Certified Reference Material; Fumaric acid, United States Pharmacopeia (USP) Reference Standard; Fumaric acid, European Pharmacopoeia (EP) Reference Standard; Fumaric acid, anhydrous, free-flowing, Redi-Dri(TM), >=99\\%; Fumaric acid, certified reference material, TraceCERT(R); Fumarate; 2-Butenedioic acid; Trans-Butenedioic acid; Fumaric acid, BioReagent, suitable for cell culture; SODIUM AUROTHIOMALATE IMPURITY B [EP IMPURITY]; SODIUM AUROTHIOMALATE IMPURITY B (EP IMPURITY); 4-02-00-02202 (Beilstein Handbook Reference); Fumaric acid, Vetec(TM) reagent grade, 99\\%; Fumaric acid, tested according to USP/NF; Fumaric acid, qNMR Standard for DMSO; trans-1,2-Ethylenediccarboxylic acid; 26B3632D-E93F-4655-90B0-3C17855294BA; Acido trans 1,2-etilendicarbossilico; 1,2-Ethenedicarboxylic acid, trans-; Fumaric acid, puriss., >=99.5\\% (T); MALIC ACID IMPURITY A (EP IMPURITY); trans-1,2-Ethylenedicarboxylic acid; Acido trans 1,2-etenedicarbossilico; MALIC ACID IMPURITY A [EP IMPURITY]; 1,2-Ethylenedicarboxylic acid, (E); trans-1,2-Ethenedicarboxylic acid; (E)-1,2-Ethylenedicarboxylic acid; trans-1,2-Ethylenedicarboxylate; 2-Butenedioic acid (2E)- (9CI); Fumaric acid, >=99\\%, FCC, FG; 1,2-ethylenedicarboxylic acid; FUMARIC ACID [USP IMPURITY]; FUMARIC ACID (USP IMPURITY); Futrans-2-Butenedioic Acid; Fumaric acid, >=99.0\\% (T); trans-Ethylendicarbonsaure; trans-but-2-enedioic acid; Kyselina fumarova [Czech]; (2E)-2-Butenedioic acid #; ethylenedicarboxylic acid; 2-butenedioic acid, (2E)-; 2(TRANS)-BUTENEDIOIC ACID; trans-2-Butenedioic acid; (2E)-but-2-enedioic acid; 2-Butenedioic acid (2E)-; 2-Butenedioic acid, (E)-; (Trans)-butenedioic acid; (2E)-2-butenedioic acid; (2Z)-2-Butenedioic acid; Acido trans butendioico; FUMARICUM ACIDUM [HPUS]; (E)-but-2-enedioic acid; 2-Butenedioic acid (E)-; Butenedioic acid, (E)-; 2-(E)-Butenedioic acid; (E)-2-butenedioic acid; trans-Butenedioic acid; FUMARIC ACID [USP-RS]; FUMARIC ACID (USP-RS); FUMARIC ACID [WHO-DD]; trans-But-2-enedioate; (E)-Butenedioic acid; (2E)-but-2-enedioate; FUMARIC ACID (MART.); FUMARIC ACID [MART.]; E-2-Butenedioic acid; trans-2-Butenedioate; Maleic acid-2,3-13C2; trans-2-Butendisaure; Fumaric acid, >=99\\%; FUMARIC ACID [VANDF]; (2E)-2-Butenedioate; FUMARIC ACID [HSDB]; FUMARIC ACID [INCI]; FUMARIC ACID [FHFI]; Lichenic acid (VAN); But-2-enedioic acid; magnesium fumarate; 2-(E)-Butenedioate; 2-Butenedioic acid; Fumaric acid, 99\\%; trans-Butenedioate; Maleic-2,3-d2 acid; (E)-2-Butenedioate; Fumaric acid (8CI); but-2-enedioicacid; FUMARIC ACID [FCC]; FUMARIC ACID [II]; Kyselina fumarova; Acido allomaleico; FUMARIC ACID (II); FUMARIC ACID [MI]; Fumaric acid (NF); Fumaric acid [NF]; ammonium fumarate; Allomalenic acid; fumarate dianion; Butenedioic acid; Fumaric Acid,(S); Fumaricum acidum; Allomaleic-acid; Allomaleic acid; Acido lichenico; sodium fumarate; UNII-88XHZ13131; WLN: QV1U1VQ-T; Acido fumarico; Acido boletico; Lichenic acid; fumeric acid; fumarate, 10; fumarate(2-); Boletic-acid; Donitic acid; Tumaric acid; Boletic acid; Fumaric Acid; FC 33 (acid); Tox21_302826; Tox21_201769; Fumarsaeure; Allomaleate; fumarsaure; 88XHZ13131; AI3-24236; Lichenate; fumarate; Boletate; mafusol; Fumaric; Furamag; 1, (E); FC 33; e297; fum; Fumaric acid



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(3)

PlantCyc(0)

代谢反应

731 个相关的代谢反应过程信息。

Reactome(70)

BioCyc(8)

WikiPathways(4)

Plant Reactome(639)

INOH(10)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

52 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Antika Boondaeng, Jureeporn Keabpimai, Chanaporn Trakunjae, Nanthavut Niyomvong. Fumaric acid production from fermented oil palm empty fruit bunches using fungal isolate K20: a comparison between free and immobilized cells. PeerJ. 2024; 12(?):e17282. doi: 10.7717/peerj.17282. [PMID: 38666083]
  • Tantan Gao, Xudong Wang, Yanqiu Qin, Zhengguang Ren, Xiaoyan Zhao. Watermelon Root Exudates Enhance Root Colonization of Bacillus amyloliquefaciens TR2. Current microbiology. 2023 Feb; 80(4):110. doi: 10.1007/s00284-023-03206-2. [PMID: 36802037]
  • Fei Sun, Xiang-Qin Wu, Yue Qi, Xing-Yu Chen, Yu-Hua Cao, Jian-Gang Wang, Shu-Mei Wang, Sheng-Wang Liang. [Application of partial least squares algorithm to explore bioactive components of crude and stir-baked hawthorn for invigorating spleen and promoting digestion]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Feb; 48(4):958-965. doi: 10.19540/j.cnki.cjcmm.20220712.302. [PMID: 36872266]
  • Anjali Zaveri, Jacqueline Edwards, Simone Rochfort. Production of Primary Metabolites by Rhizopus stolonifer, Causal Agent of Almond Hull Rot Disease. Molecules (Basel, Switzerland). 2022 Oct; 27(21):. doi: 10.3390/molecules27217199. [PMID: 36364023]
  • S V Popov, R G Guseynov, O N Skryabin, K V Sivak, V V Perepelitsa, A V Davydov, R S Barhitdinov, A S Katunin, M M Mirzabekov. [Evaluation of the results of sodium fumarate, furosemide, and mannitol on the initiation and outcome of renal warm ischemia in an experimental study]. Urologiia (Moscow, Russia : 1999). 2022 May; ?(2):18-26. doi: . [PMID: 35485810]
  • Aysegul Eroglu, Abdulahad Dogan. Investigation of the phytochemical composition and remedial effects of southern grape hyacinth (Muscari neglectum Guss. ex Ten.) plant extract against carbon tetrachloride-induced oxidative stress in rats. Drug and chemical toxicology. 2022 Apr; ?(?):1-12. doi: 10.1080/01480545.2022.2058011. [PMID: 35373681]
  • Fayiz M Reda, Ismail E Ismail, Adel I Attia, Ahmed M Fikry, Eman Khalifa, Mahmoud Alagawany. Use of fumaric acid as a feed additive in quail's nutrition: its effect on growth rate, carcass, nutrient digestibility, digestive enzymes, blood metabolites, and intestinal microbiota. Poultry science. 2021 Dec; 100(12):101493. doi: 10.1016/j.psj.2021.101493. [PMID: 34715545]
  • Zilong Li, Qinhua Chen, Jin Wang, Xiaoyan Pan, Wen Lu. Research Progress and Application of Bioorthogonal Reactions in Biomolecular Analysis and Disease Diagnosis. Topics in current chemistry (Cham). 2021 Sep; 379(6):39. doi: 10.1007/s41061-021-00352-8. [PMID: 34590223]
  • Niloufar Salehi, Gislaine Kuminek, Jozef Al-Gousous, David C Sperry, Dale E Greenwood, Nicholas M Waltz, Gordon L Amidon, Robert M Ziff, Gregory E Amidon. Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transport Analysis. Molecular pharmaceutics. 2021 09; 18(9):3326-3341. doi: 10.1021/acs.molpharmaceut.1c00262. [PMID: 34428047]
  • Sengnolotha Marak, Elena Shumilina, Nutan Kaushik, Eva Falch, Alexander Dikiy. Effect of Different Drying Methods on the Nutritional Value of Hibiscus sabdariffa Calyces as Revealed by NMR Metabolomics. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061675. [PMID: 33802805]
  • G A Nagana Gowda, Natalie N Hong, Daniel Raftery. Evaluation of Fumaric Acid and Maleic Acid as Internal Standards for NMR Analysis of Protein Precipitated Plasma, Serum, and Whole Blood. Analytical chemistry. 2021 02; 93(6):3233-3240. doi: 10.1021/acs.analchem.0c04766. [PMID: 33538164]
  • Kerri M Smith, Ian D Wilson, Paul D Rainville. Sensitive and Reproducible Mass Spectrometry-Compatible RP-UHPLC Analysis of Tricarboxylic Acid Cycle and Related Metabolites in Biological Fluids: Application to Human Urine. Analytical chemistry. 2021 01; 93(2):1009-1015. doi: 10.1021/acs.analchem.0c03863. [PMID: 33290053]
  • Wioletta Siemiradzka, Barbara Dolińska, Florian Ryszka. Preparation of Sterile Raw Material - Chicken Eggshells in the Process of their Transformation into Selected Calcium Salts. Current pharmaceutical biotechnology. 2021; 22(2):299-304. doi: 10.2174/1389201021666200903120835. [PMID: 32881665]
  • Gurpreet Kaur, Thippeswamy Boreddy Shivanandappa, Manish Kumar, Ajay Singh Kushwah. Fumaric acid protect the cadmium-induced hepatotoxicity in rats: owing to its antioxidant, anti-inflammatory action and aid in recast the liver function. Naunyn-Schmiedeberg's archives of pharmacology. 2020 10; 393(10):1911-1920. doi: 10.1007/s00210-020-01900-7. [PMID: 32440768]
  • Syed Ilias Basha, Somnath Ghosh, K Vinothkumar, B Ramesh, P Hema Praksh Kumari, K V Murali Mohan, E Sukumar. Fumaric acid incorporated Ag/agar-agar hybrid hydrogel: A multifunctional avenue to tackle wound healing. Materials science & engineering. C, Materials for biological applications. 2020 Jun; 111(?):110743. doi: 10.1016/j.msec.2020.110743. [PMID: 32279739]
  • Gulsah Gundogdu, Onur Senol, Fatma Demirkaya Miloglu, Yavuzer Koza, Fuat Gundogdu, Ahmet Hacımüftüoğlu, A M Abd El-Aty. Serum metabolite profiling of ST-segment elevation myocardial infarction using liquid chromatography quadrupole time-of-flight mass spectrometry. Biomedical chromatography : BMC. 2020 Feb; 34(2):e4738. doi: 10.1002/bmc.4738. [PMID: 31677392]
  • Chien-Chang Shen, Wen-Chi Wei, Lie-Chwen Lin. Diterpenoids and Bisnorditerpenoids from Blumea aromatica. Journal of natural products. 2019 11; 82(11):3181-3185. doi: 10.1021/acs.jnatprod.9b00674. [PMID: 31646857]
  • Masumeh Doosti, Mir Saeed Seyed Dorraji, Seyedeh Neda Mousavi, Mohammad Hossein Rasoulifard, Seyed Hojjat Hosseini. Enhancing quercetin bioavailability by super paramagnetic starch-based hydrogel grafted with fumaric acid: An in vitro and in vivo study. Colloids and surfaces. B, Biointerfaces. 2019 Nov; 183(?):110487. doi: 10.1016/j.colsurfb.2019.110487. [PMID: 31518957]
  • Forouzan Heidari, Abbas Bahari, Ali Amarlou, Barat Ali Fakheri. Fumaric acids as a novel antagonist of TLR-4 pathway mitigates arsenic-exposed inflammation in human monocyte-derived dendritic cells. Immunopharmacology and immunotoxicology. 2019 Aug; 41(4):513-520. doi: 10.1080/08923973.2019.1645166. [PMID: 31397191]
  • Zong Xian Zhu, Dan Li Jiang, Bi Jun Li, Hui Qin, Zi Ning Meng, Hao Ran Lin, Jun Hong Xia. Differential Transcriptomic and Metabolomic Responses in the Liver of Nile Tilapia (Oreochromis niloticus) Exposed to Acute Ammonia. Marine biotechnology (New York, N.Y.). 2019 Aug; 21(4):488-502. doi: 10.1007/s10126-019-09897-8. [PMID: 31076921]
  • Jin-Seok Choi, Jong Chan Byeon, Jeong-Sook Park. Naftopidil-fumaric acid interaction in a solid dispersion system: Improving the dissolution rate and oral absorption of naftopidil in rats. Materials science & engineering. C, Materials for biological applications. 2019 Feb; 95(?):264-274. doi: 10.1016/j.msec.2018.10.089. [PMID: 30573249]
  • Ruixia Lan, Inho Kim. Effects of organic acid and medium chain fatty acid blends on the performance of sows and their piglets. Animal science journal = Nihon chikusan Gakkaiho. 2018 Dec; 89(12):1673-1679. doi: 10.1111/asj.13111. [PMID: 30270486]
  • Guangyuan Wang, Tingting Bai, Zhengang Miao, Weiguang Ning, Wenxing Liang. Simultaneous production of single cell oil and fumaric acid by a newly isolated yeast Aureobasidium pullulans var. aubasidani DH177. Bioprocess and biosystems engineering. 2018 Nov; 41(11):1707-1716. doi: 10.1007/s00449-018-1994-0. [PMID: 30069713]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Juan P Zubimendi, Andrea Martinatto, Maria P Valacco, Silvia Moreno, Carlos S Andreo, María F Drincovich, Marcos A Tronconi. The complex allosteric and redox regulation of the fumarate hydratase and malate dehydratase reactions of Arabidopsis thaliana Fumarase 1 and 2 gives clues for understanding the massive accumulation of fumarate. The FEBS journal. 2018 06; 285(12):2205-2224. doi: 10.1111/febs.14483. [PMID: 29688630]
  • Shatrupa Ray, Sandhya Mishra, Kartikay Bisen, Surendra Singh, Birinchi Kumar Sarma, Harikesh Bahadur Singh. Modulation in phenolic root exudate profile of Abelmoschus esculentus expressing activation of defense pathway. Microbiological research. 2018 Mar; 207(?):100-107. doi: 10.1016/j.micres.2017.11.011. [PMID: 29458844]
  • Guanshi Zhang, Manjula Darshi, Kumar Sharma. The Warburg Effect in Diabetic Kidney Disease. Seminars in nephrology. 2018 03; 38(2):111-120. doi: 10.1016/j.semnephrol.2018.01.002. [PMID: 29602394]
  • N Remling, S Riede, U Meyer, A Beineke, G Breves, G Flachowsky, S Dänicke. Influence of fumaric acid on ruminal parameters and organ weights of growing bulls fed with grass or maize silage. Animal : an international journal of animal bioscience. 2017 Oct; 11(10):1754-1761. doi: 10.1017/s1751731117000696. [PMID: 28397627]
  • Xin Li, Jin Zhou, Shuiping Ouyang, Jia Ouyang, Qiang Yong. Fumaric Acid Production from Alkali-Pretreated Corncob by Fed-Batch Simultaneous Saccharification and Fermentation Combined with Separated Hydrolysis and Fermentation at High Solids Loading. Applied biochemistry and biotechnology. 2017 Feb; 181(2):573-583. doi: 10.1007/s12010-016-2232-3. [PMID: 27604834]
  • Jay Nath, Tom B Smith, Kamlesh Patel, Sam R Ebbs, Alex Hollis, Daniel A Tennant, Christian Ludwig, Andrew R Ready. Metabolic differences between cold stored and machine perfused porcine kidneys: A 1H NMR based study. Cryobiology. 2017 02; 74(?):115-120. doi: 10.1016/j.cryobiol.2016.11.006. [PMID: 27919740]
  • Yu Kyong Kim, Mun Ju Choi, Tae Young Oh, Kyung-Sang Yu, SeungHwan Lee. A comparative pharmacokinetic and tolerability analysis of the novel orotic acid salt form of tenofovir disoproxil and the fumaric acid salt form in healthy subjects. Drug design, development and therapy. 2017; 11(?):3171-3177. doi: 10.2147/dddt.s149125. [PMID: 29158663]
  • Marcos Hernández Suárez, Daniel Molina Pérez, Elena M Rodríguez-Rodríguez, Carlos Díaz Romero, Francisco Espinosa Borreguero, Purificación Galindo-Villardón. The Compositional HJ-Biplot-A New Approach to Identifying the Links among Bioactive Compounds of Tomatoes. International journal of molecular sciences. 2016 Nov; 17(11):. doi: 10.3390/ijms17111828. [PMID: 27827839]
  • M M Montiel-Rozas, E Madejón, P Madejón. Effect of heavy metals and organic matter on root exudates (low molecular weight organic acids) of herbaceous species: An assessment in sand and soil conditions under different levels of contamination. Environmental pollution (Barking, Essex : 1987). 2016 Sep; 216(?):273-281. doi: 10.1016/j.envpol.2016.05.080. [PMID: 27267743]
  • Marco Sciacovelli, Emanuel Gonçalves, Timothy Isaac Johnson, Vincent Roberto Zecchini, Ana Sofia Henriques da Costa, Edoardo Gaude, Alizee Vercauteren Drubbel, Sebastian Julian Theobald, Sandra Riekje Abbo, Maxine Gia Binh Tran, Vinothini Rajeeve, Simone Cardaci, Sarah Foster, Haiyang Yun, Pedro Cutillas, Anne Warren, Vincent Gnanapragasam, Eyal Gottlieb, Kristian Franze, Brian Huntly, Eamonn Richard Maher, Patrick Henry Maxwell, Julio Saez-Rodriguez, Christian Frezza. Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition. Nature. 2016 08; 537(7621):544-547. doi: 10.1038/nature19353. [PMID: 27580029]
  • Dong Wuk Kim, Young Hun Kim, Abid Mehmood Yousaf, Dong Shik Kim, Taek Kwan Kwon, Jung Hee Park, Yong Il Kim, Jae-Hyun Park, Sung Giu Jin, Kyung Soo Kim, Kwan Hyung Cho, Dong Xun Li, Jong Oh Kim, Chul Soon Yong, Jong Soo Woo, Han-Gon Choi. Novel montelukast sodium-loaded stable oral suspension bioequivalent to the commercial granules in rats. Archives of pharmacal research. 2016 Apr; 39(4):539-546. doi: 10.1007/s12272-015-0664-x. [PMID: 26983932]
  • Yao Shi, Susanna Tse, Brian Rago, Udeni Yapa, Fumin Li, Douglas M Fast. Quantification of fumarate and investigation of endogenous and exogenous fumarate stability in rat plasma by LC-MS/MS. Bioanalysis. 2016 Apr; 8(7):661-75. doi: 10.4155/bio-2015-0026. [PMID: 26978279]
  • Vanessa Vieira, Lillian Barros, Anabela Martins, Isabel C F R Ferreira. Nutritional and Biochemical Profiling of Leucopaxillus candidus (Bres.) Singer Wild Mushroom. Molecules (Basel, Switzerland). 2016 Jan; 21(1):99. doi: 10.3390/molecules21010099. [PMID: 26784162]
  • Alan W Bowsher, Rifhat Ali, Scott A Harding, Chung-Jui Tsai, Lisa A Donovan. Evolutionary Divergences in Root Exudate Composition among Ecologically-Contrasting Helianthus Species. PloS one. 2016; 11(1):e0148280. doi: 10.1371/journal.pone.0148280. [PMID: 26824236]
  • Da-Hao Huang, Kun Wang, Chihwei P Chiu, Tzu-Ming Pan, Tsung-Yu Tsai. Effects of chemical and low-temperature treatments and adaption on the responses of virulence factor genes and outer membrane proteins in Escherichia coli O157:H7. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. 2015 Dec; 48(6):604-12. doi: 10.1016/j.jmii.2014.03.007. [PMID: 24856424]
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