dinatin (BioDeep_00000002745)

human metabolite PANOMIX_OTCML-2023

代谢物信息卡片

Scutellarein 6-methyl ether

化学式: C16H12O6 (300.06338519999997)
中文名称: 高车前素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(c(c(c2c(c1)oc(cc2=O)c1ccc(cc1)O)O)OC)O
InChI: InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3

描述信息

Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.
Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.

同义名列表

5 个代谢物同义名

Scutellarein 6-methyl ether; 6-O-Methylapigenin; 6-methoxyapigenin; Hispidulin; dinatin

数据库引用编号

16 个数据库交叉引用编号

ChEBI: CHEBI:75902
KEGG: C10058
PubChem: 5281628
HMDB: HMDB0128581
Metlin: METLIN49584
DrugBank: DB14008
ChEMBL: CHEMBL293776
LipidMAPS: LMPK12111159
KNApSAcK: C00001050
CAS: 1447-88-7
PMhub: MS000004696
PubChem: 12244
PDB-CCD: HUL
3DMET: B03501
NIKKAJI: J12.270J
medchemexpress: HY-N1950

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

192 个相关的物种来源信息

2067805 - Abronia latifolia: 10.1080/10575639308043848
3816 - Abrus precatorius: 10.1248/CPB.46.982
282717 - Achillea ageratum:
282720 - Achillea aspleniifolia:
282730 - Achillea collina: 10.1016/0305-1978(88)90071-3
282733 - Achillea distans: 10.1016/0305-1978(88)90071-3
282739 - Achillea grandifolia: 10.1016/0305-1978(88)90033-6
13329 - Achillea millefolium:
482483 - Achillea millefolium var. millefolium: 10.1016/0031-9422(90)85371-L
282756 - Achillea pannonica: 10.1016/0305-1978(88)90071-3
282767 - Achillea setacea: 10.1016/0305-1978(88)90071-3
282770 - Achillea virescens:
4243 - Adenothamnus validus: 10.1016/0031-9422(88)87035-3
2773065 - Ageratina calophylla: 10.1016/S0031-9422(00)84545-8
2773125 - Ageratina tomentella: 10.1021/NP50046A052
230217 - Agnorhiza elata: 10.1016/S0031-9422(00)84740-8
925377 - Aloysia citrodora:
2067517 - Ambrosia hispida: 10.1021/JO01034A526
563858 - Arctotis argentea: 10.1016/S0305-1978(97)00007-0
41478 - Arctotis stoechadifolia: 10.1016/S0305-1978(97)00007-0
2906878 - Aria edulis: 10.1248/CPB.39.199
436459 - Arnica acaulis: 10.1016/0031-9422(88)83030-9
344073 - Arnica cordifolia:
436196 - Arnica discoidea: 10.1016/0305-1978(84)90032-2
436198 - Arnica gracilis: 10.1002/J.1537-2197.1987.TB12148.X
436203 - Arnica latifolia: 10.1016/0305-1978(84)90032-2
149410 - Arnica longifolia: 10.1016/S0031-9422(00)89581-3
436207 - Arnica montana: 10.1016/J.PHYTOCHEM.2005.11.018
436208 - Arnica nevadensis:
436214 - Arnica spathulata:
436457 - Arnica venosa:
436215 - Arnica viscosa:
259893 - Artemisia argyi: 10.1055/S-2003-38486
259893 - Artemisia argyi Lévl.et Vant.: -
205362 - Artemisia austriaca: 10.1515/ZNC-1995-5-604
72337 - Artemisia campestris: 10.1021/NP50043A035
1473222 - Artemisia cina: 10.1007/BF00574220
72342 - Artemisia fragrans: 10.1016/0305-1978(91)90084-D
395280 - Artemisia frigida: 10.1016/0031-9422(81)80046-5
669123 - Artemisia giraldii: 10.1055/S-1999-13965
72329 - Artemisia herba-alba:
205369 - Artemisia judaica: 10.1016/S0031-9422(00)84593-8
1227629 - Artemisia lindleyana: 10.1021/NP50043A027
86312 - Artemisia ludoviciana: 10.1016/0031-9422(82)80045-9
669133 - Artemisia mongolica: 10.1055/S-1999-13965
72348 - Artemisia monosperma:
1338417 - Artemisia oliveriana: 10.1016/0305-1978(91)90084-D
669136 - Artemisia pontica: 10.1016/0031-9422(92)80175-E
86318 - Artemisia sublessingiana: 10.1007/BF00597728
1193810 - Asanthus solidaginifolius: 10.1021/NP50045A042
2707421 - Baccharis flabellata: 10.1016/0031-9422(88)80471-0
114187 - Baccharis halimifolia: 10.1016/0031-9422(90)83041-X
2707510 - Baccharis pseudovaccinioides: 10.1515/ZNC-1986-1-214
1486033 - Baccharis trimera:
191144 - Bahiopsis deltoidea: 10.1016/0305-1978(89)90096-3
191146 - Bahiopsis lanata: 10.1016/0305-1978(89)90096-3
191147 - Bahiopsis microphylla: 10.1016/0305-1978(89)90096-3
191148 - Bahiopsis parishii: 10.1016/0305-1978(89)90096-3
191150 - Bahiopsis subincisa: 10.1016/0305-1978(89)90096-3
191152 - Bahiopsis triangularis: 10.1016/0305-1978(89)90096-3
230198 - Balsamorhiza deltoidea: 10.1016/0305-1978(88)90034-8
1745017 - Bejaranoa balansae: 10.1016/0031-9422(95)00806-3
2029222 - Berlandiera texana: 10.1021/NP50040A031
3508 - Betula nigra: 10.1515/ZNC-1991-5-621
1550803 - Brickellia baccharidea: 10.1016/S0031-9422(00)98581-9
191155 - Calanticaria greggii: 10.1016/0305-1978(88)90036-1
2773127 - Carphochaete bigelovii: 10.1021/NP50052A046
41507 - Centaurea aspera: 10.1016/0031-9422(91)83643-Y
1033235 - Centaurea bracteata:
41516 - Centaurea clementei:
145490 - Centaurea collina:
41522 - Centaurea cyanus: 10.1007/BF00598180
1436092 - Centaurea hierapolitana:
1486531 - Centaurea inermis: 10.1021/NP50035A034
363436 - Centaurea napifolia: 10.1023/B:CONC.0000011131.34049.E6
910632 - Centaurea phrygia: 10.1016/0031-9422(91)85119-K
1928667 - Centaurea procurrens: 10.21608/RPBS.2018.5923
634949 - Centaurea pseudoscabiosa: 10.1016/S0031-9422(02)00229-7
145513 - Centaurea raphanina: 10.1021/NP50021A025
145515 - Centaurea salonitana: 10.1016/S0031-9422(00)97993-7
2072395 - Centaurea scoparia: 10.1055/S-2006-959378
124936 - Centaurea virgata: 10.1021/NP50035A034
64995 - Cheirolophus intybaceus: 10.1016/S0031-9422(00)89537-0
41546 - Cheirolophus teydis: 10.1016/S0031-9422(00)97946-9
1308047 - Cirsium carolinianum: 10.1016/0031-9422(81)85199-0
516546 - Cirsium japonicum:
171251 - Citrus medica: 10.1016/0031-9422(81)85121-7
558546 - Citrus sudachi: 10.1016/0031-9422(81)85121-7
680190 - Clerodendrum indicum:
1048879 - Dendroviguiera adenophylla: 10.1016/0305-1978(88)90035-X
1048876 - Dendroviguiera eriophora: 10.1016/0305-1978(88)90035-X
1048883 - Dendroviguiera quinqueradiata: 10.1016/0305-1978(88)90035-X
1048873 - Dendroviguiera sphaerocephala: 10.1016/0305-1978(88)90035-X
285817 - Digitalis ferruginea: 10.1016/0031-9422(73)85152-0
38791 - Digitalis grandiflora: 10.1055/S-2007-969735
305854 - Digitalis lamarckii: 10.1055/S-2007-969735
49450 - Digitalis lanata: 10.1055/S-2007-969735
306087 - Digitalis trojana: 10.1055/S-2007-969735
1532790 - Dittrichia graveolens: 10.1016/0031-9422(91)83034-I
4249 - Dubautia arborea: 10.1016/S0305-1978(99)00015-0
240045 - Dysphania botrys: 10.1080/01811797.1985.10824657
1387318 - Eriocaulon buergerianum:
1387318 - Eriocaulon buergerianum Koern.: -
4132 - Eriodictyon californicum: 10.1021/NP50081A012
79350 - Eriodictyon sessilifolium: 10.1515/ZNC-1988-5-603
102770 - Eupatorium cannabinum:
102771 - Eupatorium capillifolium: 10.1016/0031-9422(92)80175-E
102777 - Eupatorium perfoliatum: 10.1016/J.PHYTOCHEM.2011.01.025
1031526 - Euphorbia larica:
2604028 - Flourensia cernua: 10.1016/S0031-9422(00)86634-0
353935 - Fridericia platyphylla: 10.1016/S0305-1978(01)00149-1
373155 - Gaillardia aestivalis: 10.1016/S0031-9422(00)95216-6
373167 - Gaillardia powellii: 10.1016/S0031-9422(00)81512-5
1233751 - Gardenia sootepensis: 10.1016/S0031-9422(97)01108-4
1240870 - Gardenia tubifera: 10.1016/J.TET.2003.12.010
1548572 - Geigeria burkei: 10.1016/S0031-9422(00)82648-5
289417 - Helenium amarum: 10.1021/NP50005A002
138408 - Helenium autumnale: 10.1016/S0031-9422(00)88460-5
138409 - Helenium virginicum: 10.1021/JO01288A073
73273 - Helianthus angustifolius: 10.1016/0305-1978(83)90034-0
4232 - Helianthus annuus: 10.1002/J.1537-2197.1987.TB08600.X
73279 - Helianthus carnosus: 10.1016/0305-1978(83)90034-0
73287 - Helianthus floridanus: 10.1016/0305-1978(83)90034-0
73291 - Helianthus grosseserratus: 10.1016/0031-9422(81)85225-9
73292 - Helianthus heterophyllus: 10.1016/0305-1978(83)90034-0
73296 - Helianthus longifolius: 10.1016/0305-1978(83)90034-0
73308 - Helianthus radula: 10.1016/0305-1978(83)90034-0
53583 - Helianthus simulans: 10.1016/0305-1978(83)90034-0
2907093 - Heterotheca canescens: 10.1021/NP50021A021
427640 - Heterotheca subaxillaris: 10.1016/J.PHYTOCHEM.2008.09.026
9606 - Homo sapiens: -
2741198 - Hymenoxys jamesii: 10.1016/S0305-1978(01)00100-4
557654 - Inula obtusifolia: 10.1016/S0367-326X(03)00115-1
557655 - Inula oculus-christi: 10.1016/S0367-326X(03)00115-1
58944 - Iris domestica:
82213 - Iris pseudacorus: 10.1016/0031-9422(91)83613-P
114189 - Iva frutescens:
126435 - Lantana camara:
1241423 - Lantana montevidensis: 10.1248/BPB.25.875
549292 - Layia hieracioides: 10.1016/0305-1978(88)90045-2
349397 - Layia septentrionalis: 10.1016/0305-1978(88)90045-2
694369 - Leucosceptrum canum: 10.1016/J.PHYTOL.2009.10.007
1986359 - Lippia graveolens: 10.1016/J.JFCA.2006.09.005
542673 - Lippia origanoides: 10.1016/J.JFCA.2006.09.005
1720382 - Lycopus asper: 10.1248/CPB.58.394
516551 - Lycopus lucidus: 10.1248/CPB.58.394
294739 - Mentha pulegium: 10.1016/S0031-9422(97)01042-X
38860 - Mentha suaveolens: 10.1016/S0031-9422(97)01042-X
680227 - Millingtonia hortensis:
58890 - Ononis spinosa: 10.1007/BF00577209
196747 - Onopordum acaulon: 10.1016/0031-9422(92)83742-H
642575 - Pedalium murex: 10.1016/S0031-9422(00)90057-8
119176 - Pentanema britannicum: 10.1515/ZNC-1997-3-401
2806850 - Pentanema montanum: 10.1076/PHBI.37.2.163.6079
222877 - Phyla nodiflora: 10.1016/S0031-9422(00)84701-9
214525 - Phyllospadix iwatensis: 10.1080/00021369.1979.10863833
197796 - Plantago asiatica: 10.1086/325089
29818 - Plantago major: 10.1086/325089
33090 - Plants: -
53728 - Ratibida columnifera:
53729 - Ratibida latipalearis: 10.1021/NP50077A006
2950952 - Rhaponticoides africana: 10.1007/S10600-006-0228-X
2775385 - Rhodanthe corymbiflora: 10.1016/0031-9422(89)80045-7
268905 - Salvia farinacea: 10.21779/2542-0321-2016-31-2-51-53
268906 - Salvia fruticosa:
49214 - Salvia lavandulifolia:
38868 - Salvia officinalis:
424424 - Salvia plebeia:
39367 - Salvia rosmarinus:
1933756 - Salvia sahendica: 10.1021/NP1002516
243812 - Saussurea elegans: 10.1007/BF00575206
1936783 - Schkuhria schkuhrioides: 10.1080/10575639808048865
105494 - Schoenia cassiniana: 10.1016/S0031-9422(97)00738-3
107240 - Scoparia dulcis: 10.1021/NP500150F
53167 - Scutellaria alpina: 10.1248/CPB.39.199
2858894 - Scutellaria comosa: 10.1007/BF02234938
53170 - Scutellaria orientalis: 10.1007/BF00567051
2499938 - Scutellaria ovata: 10.1021/JF00108A021
1620191 - Scutellaria racemosa: 10.1016/J.FITOTE.2010.01.018
2721171 - Scutellaria repens: 10.1248/YAKUSHI1947.114.10_775
63803 - Siparuna: 10.1016/0031-9422(93)85293-Z
558486 - Stevia monardifolia: 10.1021/NP50039A036
558494 - Stevia origanoides: 10.1021/NP50039A036
145831 - Stizolophus coronopifolius: 10.1016/S0031-9422(00)85520-X
301877 - Tanacetum balsamita: 10.1515/ZNC-1997-3-401
647961 - Tanacetum densum:
127999 - Tanacetum parthenium: 10.1016/S0031-9422(99)00474-4
128002 - Tanacetum vulgare: 10.1016/S0031-9422(99)00021-7
41650 - Tarchonanthus camphoratus: 10.21608/BFSA.2002.65503
684020 - Tithonia diversifolia:
40727 - Warionia saharae: 10.1055/S-2003-39703
125667 - Xerochrysum viscosum: 10.1016/0031-9422(93)85293-Z

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Xiaoqian Li, Yongqing Gu, Lihong Ren, Qingqing Cai, Yan Qiu, Jie He, Wei Qu, Wei Ji. Study of hispidulin in the treatment of uric acid nephropathy based on NF-κB signaling pathway. Chemical biology & drug design. 2023 Oct; ?(?):. doi: 10.1111/cbdd.14367. [PMID: 37880153]
Yanhong Sun, Xiaoyan Duan, Fenghe Wang, Huixin Tan, Jiahuan Hu, Wanting Bai, Xinbo Wang, Baolian Wang, Jinping Hu. Inhibitory effects of flavonoids on glucose transporter 1 (GLUT1): From library screening to biological evaluation to structure-activity relationship. Toxicology. 2023 Mar; ?(?):153475. doi: 10.1016/j.tox.2023.153475. [PMID: 36870413]
Adriana Cotta Cardoso Reis, Gabriel Mendonça Valente, Breno de Mello Silva, Cíntia Lopes de Brito Magalhães, Markus Kohlhoff, Geraldo Célio Brandão. Anti-arboviral activity and chemical characterization of hispidulin and ethanolic extracts from Millingtonia hortensis L.f. and Oroxylum indicum (L.) Kurz (Bignoniaceae). Natural product research. 2023 Feb; 37(4):613-617. doi: 10.1080/14786419.2022.2065485. [PMID: 35428404]
Kubra Koc, Nihal Simsek Ozek, Ferhunde Aysin, Ozlem Demir, Asli Yilmaz, Mehmet Yilmaz, Fatime Geyikoglu, Huseyin Serkan Erol. Hispidulin exerts a protective effect against oleic acid induced-ARDS in the rat via inhibition of ACE activity and MAPK pathway. International journal of environmental health research. 2023 Jan; ?(?):1-12. doi: 10.1080/09603123.2023.2166023. [PMID: 36624973]
Kacper Kut, Grzegorz Bartosz, Mirosław Soszyński, Izabela Sadowska-Bartosz. Antioxidant properties of hispidulin. Natural product research. 2022 Dec; 36(24):6401-6404. doi: 10.1080/14786419.2022.2032050. [PMID: 35073790]
Dahae Lee, Ji Hwan Lee, Byoung Ha Kim, Sanghyun Lee, Dong-Wook Kim, Ki Sung Kang. Phytochemical Combination (p-Synephrine, p-Octopamine Hydrochloride, and Hispidulin) for Improving Obesity in Obese Mice Induced by High-Fat Diet. Nutrients. 2022 May; 14(10):. doi: 10.3390/nu14102164. [PMID: 35631305]
Yao Chen, Jiaojiao Sun, Zhiyun Zhang, Xiaotong Liu, Qiaozhi Wang, Yang Yu. The potential effects and mechanisms of hispidulin in the treatment of diabetic retinopathy based on network pharmacology. BMC complementary medicine and therapies. 2022 May; 22(1):141. doi: 10.1186/s12906-022-03593-2. [PMID: 35590353]
Kiryeong Kim, Jaechan Leem. Hispidulin Ameliorates Endotoxin-Induced Acute Kidney Injury in Mice. Molecules (Basel, Switzerland). 2022 Mar; 27(6):. doi: 10.3390/molecules27062019. [PMID: 35335387]
Dahae Lee, Hee Jae Kwak, Byoung Ha Kim, Seung Hyun Kim, Dong-Wook Kim, Ki Sung Kang. Combined Anti-Adipogenic Effects of Hispidulin and p-Synephrine on 3T3-L1 Adipocytes. Biomolecules. 2021 11; 11(12):. doi: 10.3390/biom11121764. [PMID: 34944408]
Ahmed A Al-Karmalawy, Mai M Farid, Ahmed Mostafa, Alia Y Ragheb, Sara H Mahmoud, Mahmoud Shehata, Noura M Abo Shama, Mohamed GabAllah, Gomaa Mostafa-Hedeab, Mona M Marzouk. Naturally Available Flavonoid Aglycones as Potential Antiviral Drug Candidates against SARS-CoV-2. Molecules (Basel, Switzerland). 2021 Oct; 26(21):. doi: 10.3390/molecules26216559. [PMID: 34770969]
Ece Sevgi, Aydan Dag, Çağla Kızılarslan-Hançer, Sezen Atasoy, Belma Zengin Kurt, Öznur Aksakal. Evaluation of cytotoxic and antioxidant potential of Dittrichia viscosa (L.) Greuter used in traditional medicine. Journal of ethnopharmacology. 2021 Aug; 276(?):114211. doi: 10.1016/j.jep.2021.114211. [PMID: 34015367]
Yuanyuan Wang, Shanqi Guo, Yingjie Jia, Xiaoyu Yu, Ruiyu Mou, Xiaojiang Li. Hispidulin inhibits proliferation, migration, and invasion by promoting autophagy via regulation of PPARγ activation in prostate cancer cells and xenograft models. Bioscience, biotechnology, and biochemistry. 2021 Mar; 85(4):786-797. doi: 10.1093/bbb/zbaa108. [PMID: 33590833]
Piseth Nhoek, Hee-Sung Chae, Young-Mi Kim, Pisey Pel, Jungmoo Huh, Hyun Woo Kim, Young Hee Choi, Kyeong Lee, Young-Won Chin. Sesquiterpenoids from the Aerial Parts of Salvia plebeia with Inhibitory Activities on Proprotein Convertase Subtilisin/Kexin Type 9 Expression. Journal of natural products. 2021 02; 84(2):220-229. doi: 10.1021/acs.jnatprod.0c00829. [PMID: 33567826]
Shih-Chung Yen, Liang-Chieh Chen, Han-Li Huang, Sin-Ting Ngo, Yi-Wen Wu, Tony Eight Lin, Tzu-Ying Sung, Ssu-Ting Lien, Hui-Ju Tseng, Shiow-Lin Pan, Wei-Jan Huang, Kai-Cheng Hsu. Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia. Journal of natural products. 2021 01; 84(1):1-10. doi: 10.1021/acs.jnatprod.0c00589. [PMID: 33393294]
Kaili Liu, Fei Zhao, Jingjing Yan, Zhengchao Xia, Dandan Jiang, Peizhi Ma. Hispidulin: A promising flavonoid with diverse anti-cancer properties. Life sciences. 2020 Oct; 259(?):118395. doi: 10.1016/j.lfs.2020.118395. [PMID: 32905830]
Xiaoqing Fan, Jie Bai, Minwan Hu, Yanxia Xu, Shengyu Zhao, Yanhong Sun, Baolian Wang, Jinping Hu, Yan Li. Drug interaction study of flavonoids toward OATP1B1 and their 3D structure activity relationship analysis for predicting hepatoprotective effects. Toxicology. 2020 05; 437(?):152445. doi: 10.1016/j.tox.2020.152445. [PMID: 32259555]
James M Brimson, Nattawat Onlamoon, Tewin Tencomnao, Premrutai Thitilertdecha. Clerodendrum petasites S. Moore: The therapeutic potential of phytochemicals, hispidulin, vanillic acid, verbascoside, and apigenin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Oct; 118(?):109319. doi: 10.1016/j.biopha.2019.109319. [PMID: 31404773]
Pengpeng An, Jing Xie, Sha Qiu, Yongji Liu, Jianing Wang, Xiaohui Xiu, Ling Li, Ming Tang. Hispidulin exhibits neuroprotective activities against cerebral ischemia reperfusion injury through suppressing NLRP3-mediated pyroptosis. Life sciences. 2019 Sep; 232(?):116599. doi: 10.1016/j.lfs.2019.116599. [PMID: 31247210]
Dong Eun Kim, Kyoung-Jin Min, Min-Jong Kim, Sang-Hyun Kim, Taeg Kyu Kwon. Hispidulin Inhibits Mast Cell-Mediated Allergic Inflammation through Down-Regulation of Histamine Release and Inflammatory Cytokines. Molecules (Basel, Switzerland). 2019 Jun; 24(11):. doi: 10.3390/molecules24112131. [PMID: 31195760]
Mei Han, Hui Gao, Jing Xie, Yin-Ping Yuan, Quan Yuan, Ming-Quan Gao, Kai-Li Liu, Xue-Hong Chen, Yan-Tao Han, Zhi-Wu Han. Hispidulin induces ER stress-mediated apoptosis in human hepatocellular carcinoma cells in vitro and in vivo by activating AMPK signaling pathway. Acta pharmacologica Sinica. 2019 May; 40(5):666-676. doi: 10.1038/s41401-018-0159-7. [PMID: 30218072]
Xiaopu Ren, Yingjie Bao, Yuxia Zhu, Shixin Liu, Zengqi Peng, Yawei Zhang, Guanghong Zhou. Isorhamnetin, Hispidulin, and Cirsimaritin Identified in Tamarix ramosissima Barks from Southern Xinjiang and Their Antioxidant and Antimicrobial Activities. Molecules (Basel, Switzerland). 2019 Jan; 24(3):. doi: 10.3390/molecules24030390. [PMID: 30678248]
Seul Gi Lee, Jin Soo Kim, Kyoungjin Min, Taeg Kyu Kwon, Ju-Ock Nam. Hispidulin inhibits adipogenesis in 3T3-L1 adipocytes through PPARγ pathway. Chemico-biological interactions. 2018 Sep; 293(?):89-93. doi: 10.1016/j.cbi.2018.07.027. [PMID: 30055130]
Fengbo Wu, Sijia Li, Nan Zhang, Wei Huang, Xiang Li, Manyi Wang, Ding Bai, Bo Han. Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Aug; 104(?):307-314. doi: 10.1016/j.biopha.2018.05.017. [PMID: 29775899]
Abolfazl Shakeri, Elaheh Amini, Javad Asili, Milena Masullo, Sonia Piacente, Mehrdad Iranshahi. Screening of several biological activities induced by different sesquiterpene lactones isolated from Centaurea behen L. and Rhaponticum repens (L.) Hidalgo. Natural product research. 2018 Jun; 32(12):1436-1440. doi: 10.1080/14786419.2017.1344661. [PMID: 28641489]
Pengpeng An, Tianhui Wu, Huanqing Yu, Kun Fang, Zhizhen Ren, Ming Tang. Hispidulin Protects Against Focal Cerebral Ischemia Reperfusion Injury in Rats. Journal of molecular neuroscience : MN. 2018 Jun; 65(2):203-212. doi: 10.1007/s12031-018-1086-2. [PMID: 29799104]
Prashant Joshi, Vinay R Sonawane, Ibidapo S Williams, Glen J P McCann, Linda Gatchie, Rajni Sharma, Naresh Satti, Bhabatosh Chaudhuri, Sandip B Bharate. Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository. MedChemComm. 2018 Feb; 9(2):371-382. doi: 10.1039/c7md00388a. [PMID: 30108931]
Hui Gao, Ming-Quan Gao, Jian-Jun Peng, Mei Han, Kai-Li Liu, Yan-Tao Han. Hispidulin mediates apoptosis in human renal cell carcinoma by inducing ceramide accumulation. Acta pharmacologica Sinica. 2017 Dec; 38(12):1618-1631. doi: 10.1038/aps.2017.154. [PMID: 29119970]
Yoon Kyoung Lee, Eun Young Hong, Wan Kyunn Whang. Inhibitory Effect of Chemical Constituents Isolated from Artemisia iwayomogi on Polyol Pathway and Simultaneous Quantification of Major Bioactive Compounds. BioMed research international. 2017; 2017(?):7375615. doi: 10.1155/2017/7375615. [PMID: 28512639]
Xinchi Wu, Juan Xu. New Role of Hispidulin in Lipid Metabolism: PPARα Activator. Lipids. 2016 11; 51(11):1249-1257. doi: 10.1007/s11745-016-4200-7. [PMID: 27744606]
Fuqiang Li, Xiang Li, Yunjie Miao, Chenxiao Shan, Fei Yuan, Chengyao Ma, Qiwen Wang, Jianwei Chen, Yong Chen. UHPLC-MS-based metabolomics analysis on mice bearing neoplasm (H22) for hispidulin. Journal of pharmaceutical and biomedical analysis. 2016 Jun; 125(?):310-8. doi: 10.1016/j.jpba.2016.03.050. [PMID: 27077962]
Yanhua Fan, Hongyuan Lu, Hongda Ma, Fan Feng, Xiaolong Hu, Qiao Zhang, Jian Wang, Yongnan Xu, Qingchun Zhao. Bioactive compounds of Eriocaulon sieboldianum blocking proliferation and inducing apoptosis of HepG2 cells might be involved in Aurora kinase inhibition. Food & function. 2015 Dec; 6(12):3746-59. doi: 10.1039/c5fo00371g. [PMID: 26369427]
Wei-Jan Huang, Hsin-Jung Lee, Hon-Lie Chen, Pi-Chuan Fan, Yuan-Ling Ku, Lih-Chu Chiou. Hispidulin, a constituent of Clerodendrum inerme that remitted motor tics, alleviated methamphetamine-induced hyperlocomotion without motor impairment in mice. Journal of ethnopharmacology. 2015 May; 166(?):18-22. doi: 10.1016/j.jep.2015.03.001. [PMID: 25764963]
Tzu Yu Lin, Cheng Wei Lu, Su Jane Wang, Shu Kuei Huang. Protective effect of hispidulin on kainic acid-induced seizures and neurotoxicity in rats. European journal of pharmacology. 2015 May; 755(?):6-15. doi: 10.1016/j.ejphar.2015.02.041. [PMID: 25746462]
Klaokwan Srisook, Ekaruth Srisook, Wenuka Nachaiyo, Mingkwan Chan-In, Jitra Thongbai, Karnjanapa Wongyoo, Sasithorn Chawsuanthong, Kanita Wannasri, Sudarat Intasuwan, Kingkan Watcharanawee. Bioassay-guided isolation and mechanistic action of anti-inflammatory agents from Clerodendrum inerme leaves. Journal of ethnopharmacology. 2015 May; 165(?):94-102. doi: 10.1016/j.jep.2015.02.043. [PMID: 25725433]
Hui Gao, Qixiao Jiang, Yantao Han, Jianjun Peng, Chunbo Wang. Hispidulin potentiates the antitumor effect of sunitinib against human renal cell carcinoma in laboratory models. Cell biochemistry and biophysics. 2015 Mar; 71(2):757-64. doi: 10.1007/s12013-014-0260-6. [PMID: 25260394]
Vassiliki Exarchou, Loukas Kanetis, Zenovia Charalambous, Sandra Apers, Luc Pieters, Vassilis Gekas, Vlasios Goulas. HPLC-SPE-NMR characterization of major metabolites in Salvia fruticosa Mill. extract with antifungal potential: relevance of carnosic acid, carnosol, and hispidulin. Journal of agricultural and food chemistry. 2015 Jan; 63(2):457-63. doi: 10.1021/jf5050734. [PMID: 25537192]
Qing Liu, Qi-Ming Yang, Hai-Jun Hu, Li Yang, Ying-Bo Yang, Gui-Xin Chou, Zheng-Tao Wang. Bioactive diterpenoids and flavonoids from the aerial parts of Scoparia dulcis. Journal of natural products. 2014 Jul; 77(7):1594-600. doi: 10.1021/np500150f. [PMID: 24955889]
Rongkui Zhou, Zhaohong Wang, Chao Ma. Hispidulin exerts anti-osteoporotic activity in ovariectomized mice via activating AMPK signaling pathway. Cell biochemistry and biophysics. 2014 Jun; 69(2):311-7. doi: 10.1007/s12013-013-9800-8. [PMID: 24338527]
Lei Chen, Young-Hwa Kang. Antioxidant and enzyme inhibitory activities of Plebeian herba (Salvia plebeia R. Br.) under different cultivation conditions. Journal of agricultural and food chemistry. 2014 Mar; 62(10):2190-7. doi: 10.1021/jf404570s. [PMID: 24422962]
Sin-Hye Park, Jung-Lye Kim, Min-Kyung Kang, Ju-Hyun Gong, Seon-Young Han, Jae-Hoon Shim, Soon Sung Lim, Young-Hee Kang. Sage weed (Salvia plebeia) extract antagonizes foam cell formation and promotes cholesterol efflux in murine macrophages. International journal of molecular medicine. 2012 Nov; 30(5):1105-12. doi: 10.3892/ijmm.2012.1103. [PMID: 22922992]
Ayumi Uehara, Tsukasa Iwashina. Flavonoids from the Japanese monotypic genus, Nipponanthemum. Natural product communications. 2012 Aug; 7(8):1005-6. doi: . [PMID: 22978216]
Peter Forgo, István Zupkó, Judit Molnár, Andrea Vasas, György Dombi, Judit Hohmann. Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L. Fitoterapia. 2012 Jul; 83(5):921-5. doi: 10.1016/j.fitote.2012.04.006. [PMID: 22537643]
Wamidh H Talib, Musa H Abu Zarga, Adel M Mahasneh. Antiproliferative, antimicrobial and apoptosis inducing effects of compounds isolated from Inula viscosa. Molecules (Basel, Switzerland). 2012 Mar; 17(3):3291-303. doi: 10.3390/molecules17033291. [PMID: 22418930]
Souheila Louaar, Amel Achouri, Mostefa Lefahal, Hocine Laouer, Kamel Medjroubi, Helmut Duddeck, Salah Akkal. Flavonoids from Algerian endemic Centaurea microcarpa and their chemotaxonomical significance. Natural product communications. 2011 Nov; 6(11):1603-4. doi: . [PMID: 22224272]
Maria Graça Miguel, Maria Dulce Antunes. Is propolis safe as an alternative medicine?. Journal of pharmacy & bioallied sciences. 2011 Oct; 3(4):479-95. doi: 10.4103/0975-7406.90101. [PMID: 22219581]
Kumaresan P Thirupathy, Asish Tulshkar, C Vijaya. Neuropharmacological activity of Lippia nodiflora Linn. Pharmacognosy research. 2011 Jul; 3(3):194-200. doi: 10.4103/0974-8490.85007. [PMID: 22022169]
Lijun He, Yuanyuan Wu, Lei Lin, Jieqiong Wang, Yougen Wu, Yihua Chen, Zhengfang Yi, Mingyao Liu, Xiufeng Pang. Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K/Akt/mTOR signaling pathway. Cancer science. 2011 Jan; 102(1):219-25. doi: 10.1111/j.1349-7006.2010.01778.x. [PMID: 21087351]
Haytham M Wahba, Sameh F AbouZid, Amany A Sleem, Sandra Apers, Luc Pieters, Abdelaaty A Shahat. Chemical and biological investigation of some Clerodendrum species cultivated in Egypt. Pharmaceutical biology. 2011 Jan; 49(1):66-72. doi: 10.3109/13880209.2010.494674. [PMID: 20738216]
Long Huang, Junshan Yang, Yong Peng, Peigen Xiao. [Chemical constituents of Iris dichotoma]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Dec; 35(23):3168-71. doi: . [PMID: 21355241]
Jung-Mu Yang, Chao-Ming Hung, Chen-Nan Fu, Jang-Chang Lee, Chi-Hung Huang, Muh-Hwa Yang, Chih-Li Lin, Jung-Yie Kao, Tzong-Der Way. Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation. Journal of agricultural and food chemistry. 2010 Sep; 58(18):10020-6. doi: 10.1021/jf102304g. [PMID: 20734985]
Anna Walesiuk, Jolanta Nazaruk, Jan J Braszko. Pro-cognitive effects of Cirsium rivulare extracts in rats. Journal of ethnopharmacology. 2010 May; 129(2):261-6. doi: 10.1016/j.jep.2010.03.028. [PMID: 20363311]
Marcelo Aparecido da Silva, Claudia Andréa Lima Cardoso, Wagner Vilegas, Lourdes Campaner dos Santos. High-performance liquid chromatographic quantification of flavonoids in Eriocaulaceae species and their antimicrobial activity. Molecules (Basel, Switzerland). 2009 Nov; 14(11):4644-54. doi: 10.3390/molecules14114644. [PMID: 19924092]
Qi Wu, Xiuwei Yang, Lei Zou, Dexian Fu. [Bioactivity guided isolation of alpha-glucosidase inhibitor from whole herbs of Crossostephium chinense]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Sep; 34(17):2206-11. doi: . [PMID: 19943487]
Y J Xu, D X Zhao, C X Fu, L Q Cheng, N F Wang, L J Han, F S Ma. Determination of flavonoid compounds from Saussurea involucrata by liquid chromatography electrospray ionisation mass spectrometry. Natural product research. 2009; 23(18):1689-98. doi: 10.1080/14786410802187742. [PMID: 19921587]
Ye Yin, Fang-Yuan Gong, Xing-Xin Wu, Yang Sun, Yi-Hua Li, Ting Chen, Qiang Xu. Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita. Journal of ethnopharmacology. 2008 Oct; 120(1):1-6. doi: 10.1016/j.jep.2008.07.029. [PMID: 18721870]
Xiao-feng Jin, Yan-hua Lu, Dong-zhi Wei, Zheng-tao Wang. Chemical fingerprint and quantitative analysis of Salvia plebeia R.Br. by high-performance liquid chromatography. Journal of pharmaceutical and biomedical analysis. 2008 Sep; 48(1):100-4. doi: 10.1016/j.jpba.2008.05.027. [PMID: 18678457]
Ai-Lin Liu, Hai-Di Wang, Simon MingYuen Lee, Yi-Tao Wang, Guan-Hua Du. Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities. Bioorganic & medicinal chemistry. 2008 Aug; 16(15):7141-7. doi: 10.1016/j.bmc.2008.06.049. [PMID: 18640042]
Vit Koleckar, Lubomir Opletal, Eliska Brojerova, Zuzana Rehakova, Frantisek Cervenka, Katerina Kubikova, Kamil Kuca, Daniel Jun, Miroslav Polasek, Jiri Kunes, Ludek Jahodar. Evaluation of natural antioxidants of Leuzea carthamoides as a result of a screening study of 88 plant extracts from the European Asteraceae and Cichoriaceae. Journal of enzyme inhibition and medicinal chemistry. 2008 Apr; 23(2):218-24. doi: 10.1080/14756360701450806. [PMID: 18343907]
Juan C Luis, Raquel Martín, Ignacio Frías, Francisco Valdés. Enhanced carnosic acid levels in two rosemary accessions exposed to cold stress conditions. Journal of agricultural and food chemistry. 2007 Oct; 55(20):8062-6. doi: 10.1021/jf0712393. [PMID: 17760410]
Jianqing Yu, Huibin Liu, Jiachuan Lei, Wenjie Tan, Xianming Hu, Guolin Zou. Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents. Phytotherapy research : PTR. 2007 Sep; 21(9):817-22. doi: 10.1002/ptr.2062. [PMID: 17674423]
M Clavin, S Gorzalczany, A Macho, E Muñoz, G Ferraro, C Acevedo, V Martino. Anti-inflammatory activity of flavonoids from Eupatorium arnottianum. Journal of ethnopharmacology. 2007 Jul; 112(3):585-9. doi: 10.1016/j.jep.2007.04.007. [PMID: 17570627]
Canan Karamenderes, Erdal Bedir, Rahul Pawar, Sura Baykan, Ikhlas A Khan. Elemanolide sesquiterpenes and eudesmane sesquiterpene glycosides from Centaurea hierapolitana. Phytochemistry. 2007 Mar; 68(5):609-15. doi: 10.1016/j.phytochem.2006.10.013. [PMID: 17126864]
Chun-Xiang Fu, Yan-jun Xu, De-Xiu Zhao, Feng Shan Ma. A comparison between hairy root cultures and wild plants of Saussurea involucrata in phenylpropanoids production. Plant cell reports. 2006 Jan; 24(12):750-4. doi: 10.1007/s00299-005-0049-6. [PMID: 16136313]
Jolanta Nazaruk, Piotr Jakoniuk. Flavonoid composition and antimicrobial activity of Cirsium rivulare (Jacq.) All. flowers. Journal of ethnopharmacology. 2005 Nov; 102(2):208-12. doi: 10.1016/j.jep.2005.06.012. [PMID: 16061337]
Sam Medhat Salah, Anna Katharina Jäger. Two flavonoids from Artemisia herba-alba Asso with in vitro GABAA-benzodiazepine receptor activity. Journal of ethnopharmacology. 2005 May; 99(1):145-6. doi: 10.1016/j.jep.2005.01.031. [PMID: 15848034]
Filippo Cottiglia, Laura Casu, Leonardo Bonsignore, Mariano Casu, Costantino Floris, Silvio Sosa, Gianmario Altinier, Roberto Della Loggia. Topical anti-inflammatory activity of flavonoids and a new xanthone from Santolina insularis. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2005 Jan; 60(1-2):63-6. doi: 10.1515/znc-2005-1-212. [PMID: 15787246]
Alejandro Tapia, Jaime Rodriguez, Cristina Theoduloz, Susana Lopez, Gabriela Egly Feresin, Guillermo Schmeda-Hirschmann. Free radical scavengers and antioxidants from Baccharis grisebachii. Journal of ethnopharmacology. 2004 Dec; 95(2-3):155-61. doi: 10.1016/j.jep.2004.06.035. [PMID: 15507329]
María José del Baño, Juan Lorente, Julián Castillo, Obdulio Benavente-García, María Piedad Marín, José Antonio Del Río, Ana Ortuño, Isidro Ibarra. Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway. Journal of agricultural and food chemistry. 2004 Aug; 52(16):4987-92. doi: 10.1021/jf040078p. [PMID: 15291464]
Jong Cheol Park, Jong Moon Hur, Ju Gwon Park, Sang Cheol Kim, Jeong Ro Park, Seong Hee Choi, Jong Won Choi. Effects of methanol extract of Cirsium japonicum var. ussuriense and its principle, hispidulin-7-O-neohesperidoside on hepatic alcohol-metabolizing enzymes and lipid peroxidation in ethanol-treated rats. Phytotherapy research : PTR. 2004 Jan; 18(1):19-24. doi: 10.1002/ptr.1299. [PMID: 14750195]
Paula C Santos-Gomes, Rosa M Seabra, Paula B Andrade, Manuel Fernandes-Ferreira. Determination of phenolic antioxidant compounds produced by calli and cell suspensions of sage (Salvia officinalis L.). Journal of plant physiology. 2003 Sep; 160(9):1025-32. doi: 10.1078/0176-1617-00831. [PMID: 14593803]
Jeong-Min Seo, Hyun-Mi Kang, Kwang-Hee Son, Jong Han Kim, Chang Woo Lee, Hwan Mook Kim, Soo-Ik Chang, Byoung-Mog Kwon. Antitumor activity of flavones isolated from Artemisia argyi. Planta medica. 2003 Mar; 69(3):218-22. doi: 10.1055/s-2003-38486. [PMID: 12677524]
Dominique Kavvadias, Vanessa Monschein, Philipp Sand, Peter Riederer, Peter Schreier. Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. Planta medica. 2003 Feb; 69(2):113-7. doi: 10.1055/s-2003-37712. [PMID: 12624814]
Jolanta Nazaruk, Jan Gudej. Flavonoid compounds from the flowers of Cirsium rivulare (Jacq.) All. Acta poloniae pharmaceutica. 2003 Jan; 60(1):87-9. doi: ". [PMID: 12848373]
Jiau-Ching Ho, Chiu-Ming Chen. Flavonoids from the aquatic plant Eriocaulon buergerianum. Phytochemistry. 2002 Oct; 61(4):405-8. doi: 10.1016/s0031-9422(02)00218-2. [PMID: 12377234]
Tsuneatsu Nagao, Fumiko Abe, Junei Kinjo, Hikaru Okabe. Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. Biological & pharmaceutical bulletin. 2002 Jul; 25(7):875-9. doi: 10.1248/bpb.25.875. [PMID: 12132661]
A Hazekamp, R Verpoorte, A Panthong. Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites. Journal of ethnopharmacology. 2001 Nov; 78(1):45-9. doi: 10.1016/s0378-8741(01)00320-8. [PMID: 11585687]
L D Zhou, J G Yu, J Guo, S L Yang. [Compounds from roots of Chirita fimbrisepala Hand.-Mazz]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2001 Feb; 26(2):114-7. doi: ". [PMID: 12525106]
P Valentão, P B Andrade, F Areias, F Ferreres, R M Seabra. Analysis of vervain flavonoids by HPLC/Diode array detector method. Its application to quality control. Journal of agricultural and food chemistry. 1999 Nov; 47(11):4579-82. doi: 10.1021/jf990444i. [PMID: 10552853]
M Chulasiri. Mutagenicity and antimutagenicity of flavonoids extracted from Millingtonia hortensis L. The Journal of toxicological sciences. 1998 Jul; 23 Suppl 2(?):224-8. doi: 10.2131/jts.23.supplementii_224. [PMID: 9760470]
S Moro, A M van Rhee, L H Sanders, K A Jacobson. Flavonoid derivatives as adenosine receptor antagonists: a comparison of the hypothetical receptor binding site based on a comparative molecular field analysis model. Journal of medicinal chemistry. 1998 Jan; 41(1):46-52. doi: 10.1021/jm970446z. [PMID: 9438021]
X D Ji, N Melman, K A Jacobson. Interactions of flavonoids and other phytochemicals with adenosine receptors. Journal of medicinal chemistry. 1996 Feb; 39(3):781-8. doi: 10.1021/jm950661k. [PMID: 8576921]
M L Ferrándiz, G Bustos, M Payá, R Gunasegaran, M J Alcaraz. Hispidulin protection against hepatotoxicity induced by bromobenzene in mice. Life sciences. 1994; 55(8):PL145-50. doi: 10.1016/0024-3205(94)00490-0. [PMID: 8046988]
S Abdalla, M Abu-Zarga, F Afifi, S Al-Khalil, S Sabri. Effects of hispidulin, a flavone isolated from Inula viscosa, on isolated guinea-pig smooth muscle. General pharmacology. 1988; 19(4):559-63. doi: 10.1016/0306-3623(88)90164-4. [PMID: 3410278]