Linarin (BioDeep_00000230465)

 

Secondary id: BioDeep_00000180484

natural product PANOMIX_OTCML-2023


代谢物信息卡片


5-Hydroxy-2-(4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

化学式: C28H32O14 (592.1791972)
中文名称: 蒙花苷, 地奥司明EP杂质E (Linarin), 蒙花苷
谱图信息: 最多检出来源 Viridiplantae(plant) 4.88%

分子结构信息

SMILES: c(O)(c3)c(C(=O)2)c(cc3OC(O4)C(O)C(O)C(O)C(COC(O5)C(O)C(C(C5C)O)O)4)OC(=C2)c(c1)ccc(OC)c1
InChI: InChI=1/C28H32O14/c1-11-21(31)23(33)25(35)27(39-11)38-10-19-22(32)24(34)26(36)28(42-19)40-14-7-15(29)20-16(30)9-17(41-18(20)8-14)12-3-5-13(37-2)6-4-12/h3-9,11,19,21-29,31-36H,10H2,1-2H3/t11-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1

描述信息

Acquisition and generation of the data is financially supported in part by CREST/JST.
Linarin is a natural product found in Silene firma, Scoparia dulcis, and other organisms with data available.
Linarin (Buddleoside), isolated from the flower extract of Mentha arvensis, shows selective dose dependent inhibitory effect on acetylcholinesterase (AChE)[1].
Linarin (Buddleoside), isolated from the flower extract of Mentha arvensis, shows selective dose dependent inhibitory effect on acetylcholinesterase (AChE)[1].

同义名列表

39 个代谢物同义名

5-hydroxy-2-(4-methoxyphenyl)-7-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-2-tetrahydropyranyl]oxymethyl]-2-tetrahydropyranyl]oxy]-4-chromenone; 5-hydroxy-2-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-chromen-4-one; 5-hydroxy-2-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-chromone; 5-hydroxy-2-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxymethyl]oxan-2-yl]oxy-chromen-4-one; 5-hydroxy-2-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one; 7-((6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one; EINECS 207-547-6; STOCK1N-06157; 480-36-4; Linarin; Buddleoflavonoloside; Acacetin-7-O-rutinoside; acaciin; 5-Hydroxy-2-(4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one; 5-hydroxy-2-(4-methoxyphenyl)-7-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)methyl)tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one; 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-; 4H-1-BENZOPYRAN-4-ONE, 7-((6-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-5-HYDROXY-2-(4-METHOXYPHENYL)-; 7-((6-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-5-HYDROXY-2-(4-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; 7-[[6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one; 7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-4-methoxyflavone; Acacetin 7-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside; 5,7-DIHYDROXY-4-METHOXYFLAVONE-D-GLUCOSIDO-L-RHAMNOSIDE; Acacetin-7-O-(6-O-rhamnose)-beta-D-glucoside; 5-Hydroxy-4-methoxyflavone-7-O-rutinoside; Acacetin-7-O-.eta-D-rutinoside; YFVGIJBUXMQFOF-PJOVQGMDSA-N; ACACETIN-.BETA.-RUTINOSIDE; Acacetin 7-O-rutinoside; Linarigenin glycoside; Acacetin 7-rutinoside; LINARIGENIN-GLUCOSIDE; Buddleoside;Linarine; Linarin;Buddleoside; Buddleoside,(S); UNII-HBH2I685IU; LINARIN [MI]; Buddleoside; HBH2I685IU; Linarine



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Farida S Nirmala, Hyunjung Lee, Young-In Kim, Jeong-Hoon Hahm, Hyo-Deok Seo, Minjung Kim, Chang Hwa Jung, Jiyun Ahn. Exercise-induced signaling activation by Chrysanthemum zawadskii and its active compound, linarin, ameliorates age-related sarcopenia through Sestrin 1 regulation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155695. doi: 10.1016/j.phymed.2024.155695. [PMID: 38728922]
  • Yana Ye, Zhenlin Chen, Yonglin Wu, Mengmeng Gao, Anqi Zhu, Xinyuan Kuai, Duosheng Luo, Yanfen Chen, Kunping Li. Purification Process and In Vitro and In Vivo Bioactivity Evaluation of Pectolinarin and Linarin from Cirsium japonicum. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27248695. [PMID: 36557828]
  • Yating Yang, Ruining Cheng, Jingyun Liu, Jing Fang, Xiaojing Wang, Yingxue Cui, Pan Zhang, Bin Du. Linarin Protects against Cadmium-Induced Osteoporosis Via Reducing Oxidative Stress and Inflammation and Altering RANK/RANKL/OPG Pathway. Biological trace element research. 2022 Aug; 200(8):3688-3700. doi: 10.1007/s12011-021-02967-w. [PMID: 34674107]
  • Cong Xie, Shiqin Yue, Xiangzhu Li, Zongyang Li, Weiping Li, Guodong Huang, Guoxu Ma, Wenlan Liu, Yachao Wang, Yuan Zhang. A Linarin Derivative Protects against Ischemia-Induced Neuronal Injury in Mice by Promoting Cerebral Blood Flow Recovery via KDELR-Dependent CSPG4 Activation. Oxidative medicine and cellular longevity. 2022; 2022(?):6434086. doi: 10.1155/2022/6434086. [PMID: 35927993]
  • Jun Gu Kim, Jin Woo Lee, Thi Phuong Linh Le, Jae Sang Han, Yong Beom Cho, Haeun Kwon, Dongho Lee, Mi Kyeong Lee, Bang Yeon Hwang. Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production. Journal of natural products. 2021 03; 84(3):562-569. doi: 10.1021/acs.jnatprod.0c01121. [PMID: 33667099]
  • Soad A Mohamad, Eman Maher Zahran, Maha Raafat Abdel Fadeel, Amgad Albohy, Mohamed A Safwat. New Acaciin-Loaded Self-Assembled Nanofibers as MPro Inhibitors Against BCV as a Surrogate Model for SARS-CoV-2. International journal of nanomedicine. 2021; 16(?):1789-1804. doi: 10.2147/ijn.s298900. [PMID: 33688191]
  • Yang Chengyu, Zhao Long, Zhou Bin, Luan Hong, Shen Xuefei, Luo Congjuan, Cao Caixia, Xu Yan. Linarin Protects the Kidney against Ischemia/Reperfusion Injury via the Inhibition of Bioactive ETS2/IL-12. Biological & pharmaceutical bulletin. 2021; 44(1):25-31. doi: 10.1248/bpb.b20-00508. [PMID: 33390546]
  • Soo-Il Kim, Yun-Ho Kim, Beom Goo Kang, Min-Kyung Kang, Eun-Jung Lee, Dong Yeon Kim, Hyeongjoo Oh, Su Yeon Oh, Woojin Na, Soon Sung Lim, Young-Hee Kang. Linarin and its aglycone acacetin abrogate actin ring formation and focal contact to bone matrix of bone-resorbing osteoclasts through inhibition of αvβ3 integrin and core-linked CD44. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Dec; 79(?):153351. doi: 10.1016/j.phymed.2020.153351. [PMID: 32987362]
  • Young Hye Seo, Tuy An Trinh, Seung Mok Ryu, Hyo Seon Kim, Goya Choi, Byeong Cheol Moon, Sang Hee Shim, Dae Sik Jang, Dongho Lee, Ki Sung Kang, Jun Lee. Chemical Constituents from the Aerial Parts of Elsholtzia ciliata and Their Protective Activities on Glutamate-Induced HT22 Cell Death. Journal of natural products. 2020 10; 83(10):3149-3155. doi: 10.1021/acs.jnatprod.0c00756. [PMID: 32991171]
  • Dong Tian, Yong Yang, Meng Yu, Zheng-Zhou Han, Min Wei, Hong-Wu Zhang, Hong-Mei Jia, Zhong-Mei Zou. Anti-inflammatory chemical constituents of Flos Chrysanthemi Indici determined by UPLC-MS/MS integrated with network pharmacology. Food & function. 2020 Jul; 11(7):6340-6351. doi: 10.1039/d0fo01000f. [PMID: 32608438]
  • Guoyong Xie, Jie Yang, Xiaonan Wei, Qiuhong Xu, Minjian Qin. Separation of acteoside and linarin from Buddlejae Flos by high-speed countercurrent chromatography and their anti-inflammatory activities. Journal of separation science. 2020 Apr; 43(8):1450-1457. doi: 10.1002/jssc.201901062. [PMID: 32031325]
  • Yang Li, Chenxi Guang, Na Zhao, Xinchi Feng, Feng Qiu. LC-MS/MS Method for Simultaneous Determination of Linarin and Its Metabolites in Rat Plasma and Liver Tissue Samples: Application to Pharmacokinetic and Liver Tissue Distribution Study After Oral Administration of Linarin. Molecules (Basel, Switzerland). 2019 Sep; 24(18):. doi: 10.3390/molecules24183342. [PMID: 31540332]
  • Sachiko Sugimoto, Yoshi Yamano, Samar Y Desoukey, Kazuaki Katakawa, Amira S Wanas, Hideaki Otsuka, Katsuyoshi Matsunami. Isolation of Sesquiterpene-Amino Acid Conjugates, Onopornoids A-D, and a Flavonoid Glucoside from Onopordum alexandrinum. Journal of natural products. 2019 06; 82(6):1471-1477. doi: 10.1021/acs.jnatprod.8b00948. [PMID: 31199638]
  • Gabriel R Martins, Thamirys Silva da Fonseca, Lucero Martínez-Fructuoso, Rosineide Costa Simas, Fabio T Silva, Fatima Regina G Salimena, Daniela S Alviano, Celuta Sales Alviano, Gilda Guimarães Leitão, Rogelio Pereda-Miranda, Suzana G Leitão. Antifungal Phenylpropanoid Glycosides from Lippia rubella. Journal of natural products. 2019 03; 82(3):566-572. doi: 10.1021/acs.jnatprod.8b00975. [PMID: 30817148]
  • Hongxu Du, Shuaibing Zhang, Miao He, Ke Ming, Jinli Wang, Wenjuan Yuan, Mingyu Qiao, Yi Wu, Deyun Wang, Yuanliang Hu, Jiaguo Liu. Evaluation of the Therapeutic Effect of a Flavonoid Prescription against Rabbit Hemorrhagic Disease In Vivo. BioMed research international. 2019; 2019(?):5201790. doi: 10.1155/2019/5201790. [PMID: 31080820]
  • Hee-Soo Han, Ji-Sun Shin, Seung-Bin Lee, Jong Cheol Park, Kyung-Tae Lee. Cirsimarin, a flavone glucoside from the aerial part of Cirsium japonicum var. ussuriense (Regel) Kitam. ex Ohwi, suppresses the JAK/STAT and IRF-3 signaling pathway in LPS-stimulated RAW 264.7 macrophages. Chemico-biological interactions. 2018 Sep; 293(?):38-47. doi: 10.1016/j.cbi.2018.07.024. [PMID: 30053449]
  • Xinchi Feng, Yang Li, Chenxi Guang, Miao Qiao, Tong Wang, Liwei Chai, Feng Qiu. Characterization of the In Vivo and In Vitro Metabolites of Linarin in Rat Biosamples and Intestinal Flora Using Ultra-High Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Tandem Mass Spectrometry. Molecules (Basel, Switzerland). 2018 Aug; 23(9):. doi: 10.3390/molecules23092140. [PMID: 30149616]
  • Yun Chen, Ling Zeng, Jingjing Yang, Yixuan Wang, Fangke Yao, Yi Wu, Deyun Wang, Yuanliang Hu, Jiaguo Liu. Anti-DHAV-1 reproduction and immuno-regulatory effects of a flavonoid prescription on duck virus hepatitis. Pharmaceutical biology. 2017 Dec; 55(1):1545-1552. doi: 10.1080/13880209.2017.1309554. [PMID: 28385083]
  • Yun Chen, Ling Zeng, Yu Lu, Yulan Yang, Meiyun Xu, Yixuan Wang, Jiaguo Liu. Treatment effect of a flavonoid prescription on duck virus hepatitis by its hepatoprotective and antioxidative ability. Pharmaceutical biology. 2017 Dec; 55(1):198-205. doi: 10.1080/13880209.2016.1255977. [PMID: 27927057]
  • Zi-Gang Zhen, Shao-Hua Ren, Hong-Ming Ji, Jiu-Hong Ma, Xin-Min Ding, Fu-Qiang Feng, Shing-Li Chen, Peng Zou, Jin-Rui Ren, Lu Jia. Linarin suppresses glioma through inhibition of NF-κB/p65 and up-regulating p53 expression in vitro and in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Nov; 95(?):363-374. doi: 10.1016/j.biopha.2017.08.023. [PMID: 28858735]
  • Yanni Lv, Jia Fu, Xianpeng Shi, Zhiwei Yang, Shengli Han. Screening allergic components of Yejuhua injection using LAD2 cell membrane chromatography model online with high performance liquid chromatography-ion trap-time of flight-mass spectrum system. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Jun; 1055-1056(?):119-124. doi: 10.1016/j.jchromb.2017.04.045. [PMID: 28463725]
  • Xiangyang Chen, Shujing Zhang, Zinan Xuan, Dongyu Ge, Xiaoming Chen, Junjie Zhang, Qian Wang, Ying Wu, Bin Liu. The Phenolic Fraction of Mentha haplocalyx and Its Constituent Linarin Ameliorate Inflammatory Response through Inactivation of NF-κB and MAPKs in Lipopolysaccharide-Induced RAW264.7 Cells. Molecules (Basel, Switzerland). 2017 May; 22(5):. doi: 10.3390/molecules22050811. [PMID: 28509854]
  • Seung Hwan Hwang, Ji Hun Paek, Soon Sung Lim. Simultaneous Ultra Performance Liquid Chromatography Determination and Antioxidant Activity of Linarin, Luteolin, Chlorogenic Acid and Apigenin in Different Parts of Compositae Species. Molecules (Basel, Switzerland). 2016 Nov; 21(11):. doi: 10.3390/molecules21111609. [PMID: 27886116]
  • Jin-Hua Tao, Jin-Ao Duan, Shu Jiang, Yi-Yun Qian, Da-Wei Qian. Biotransformation and metabolic profile of buddleoside with human intestinal microflora by ultrahigh-performance liquid chromatography coupled to hybrid linear ion trap/orbitrap mass spectrometer. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jul; 1025(?):7-15. doi: 10.1016/j.jchromb.2016.04.055. [PMID: 27183213]
  • Hong-Ye Pan, Hai-Xin Deng, Zhou-Quan Chen, Yue-Fei Zhang, Long-Hu Wang. [Study on balance of process of alcohol precipitation of ganmaoling granules]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Apr; 41(8):1376-1379. doi: 10.4268/cjcmm20160802. [PMID: 28884526]
  • Jia Li, Lingyu Hao, Junhua Wu, Jiquan Zhang, Jiansheng Su. Linarin promotes osteogenic differentiation by activating the BMP-2/RUNX2 pathway via protein kinase A signaling. International journal of molecular medicine. 2016 Apr; 37(4):901-10. doi: 10.3892/ijmm.2016.2490. [PMID: 26935542]
  • Xinchi Feng, Youping Liu, Xin Wang, Xin Di. A rapid and sensitive LC-MS/MS method for the determination of linarin in small-volume rat plasma and tissue samples and its application to pharmacokinetic and tissue distribution study. Biomedical chromatography : BMC. 2016 Apr; 30(4):618-24. doi: 10.1002/bmc.3605. [PMID: 26385597]
  • Guo-Quan Chen, Hong-Ye Pan, Xue-Song Liu, Yue-Fei Zhang, Ping Shao, Long-Hu Wang. [On-line monitoring of extraction of coldrine by near-infrared spectrum]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Apr; 41(8):1383-1387. doi: 10.4268/cjcmm20160804. [PMID: 28884528]
  • Panpan Guo, Lihua Dong, Wenying Yan, Jianceng Wei, Chunying Wang, Zijian Zhang. Simultaneous determination of linarin, naringenin and formononetin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study after oral administration of Bushen Guchi Pill. Biomedical chromatography : BMC. 2015 Feb; 29(2):246-53. doi: 10.1002/bmc.3267. [PMID: 24920553]
  • Xu Zhao, Xin Mao, Xuan Xu, Xiaolong Li, Kaishun Bi, Ying Jia. Determination and pharmacokinetics of linarin in rat plasma after intramuscular administration of linarin solution and Yejuhua injection by HPLC. Biomedical chromatography : BMC. 2015 Feb; 29(2):164-6. doi: 10.1002/bmc.3269. [PMID: 24917464]
  • Seok-Joo Kim, Hong-Ik Cho, So-Jin Kim, Jin-Hyun Park, Joon-Sung Kim, Young Ho Kim, Sang Kook Lee, Jong-Hwan Kwak, Sun-Mee Lee. Protective effect of linarin against D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure. European journal of pharmacology. 2014 Sep; 738(?):66-73. doi: 10.1016/j.ejphar.2014.05.024. [PMID: 24877692]
  • Xinchi Feng, Youping Liu, Xin Wang, Xin Di. Effects of piperine on the intestinal permeability and pharmacokinetics of linarin in rats. Molecules (Basel, Switzerland). 2014 Apr; 19(5):5624-33. doi: 10.3390/molecules19055624. [PMID: 24786847]
  • Gui-Yuan Lv, Yan-Ping Zhang, Jian-Li Gao, Jing-Jing Yu, Jing Lei, Zhi-Ru Zhang, Bo Li, Ruan-Juan Zhan, Su-Hong Chen. Combined antihypertensive effect of luteolin and buddleoside enriched extracts in spontaneously hypertensive rats. Journal of ethnopharmacology. 2013 Nov; 150(2):507-13. doi: 10.1016/j.jep.2013.08.058. [PMID: 24080032]
  • Chong Yan, Hongju Liu, Li Lin. Rapid LC-MS/MS determination and pharmacokinetic application of linarin in rat plasma. Biomedical chromatography : BMC. 2013 Feb; 27(2):186-90. doi: 10.1002/bmc.2767. [PMID: 22674783]
  • Agung Nugroho, Sang-Cheol Lim, Jongwon Choi, Hee-Juhn Park. Identification and quantification of the sedative and anticonvulsant flavone glycoside from Chrysanthemum boreale. Archives of pharmacal research. 2013 Jan; 36(1):51-60. doi: 10.1007/s12272-013-0015-8. [PMID: 23325489]
  • Olli Salin, Liisa Törmäkangas, Maija Leinonen, Elise Saario, Marja Hagström, Raimo A Ketola, Pekka Saikku, Heikki Vuorela, Pia M Vuorela. Corn mint (Mentha arvensis) extract diminishes acute Chlamydia pneumoniae infection in vitro and in vivo. Journal of agricultural and food chemistry. 2011 Dec; 59(24):12836-42. doi: 10.1021/jf2032473. [PMID: 22073967]
  • Bui Huu Tai, Nguyen Xuan Nhiem, Tran Hong Quang, Nguyen Thi Thanh Ngan, Nguyen Huu Tung, Yohan Kim, Jung-Jin Lee, Chang-Seon Myung, Nguyen Manh Cuong, Young Ho Kim. A new iridoid and effect on the rat aortic vascular smooth muscle cell proliferation of isolated compounds from Buddleja officinalis. Bioorganic & medicinal chemistry letters. 2011 Jun; 21(11):3462-6. doi: 10.1016/j.bmcl.2011.03.078. [PMID: 21524582]
  • Nicholas K Chow, Michael Fretz, Matthias Hamburger, Veronika Butterweck. Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice. Planta medica. 2011 May; 77(8):795-803. doi: 10.1055/s-0030-1250589. [PMID: 21154200]
  • Qiaosheng Guo, Hailing Fang, Haijin Shen. [Determination of chlorogenic acid, caffeic acid and linarin in Flos Chrysanthemi Indici from different places by RP-hPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 May; 35(9):1160-3. doi: 10.4268/cjcmm20100917. [PMID: 20707074]
  • Yanyan Jiang, Renbing Shi, Bin Liu, Qiuying Wang, Ying Dai. [Studies on chemical components of Lobelia chinensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Feb; 34(3):294-7. doi: . [PMID: 19445152]
  • Ying Zhou, Yan Wang, Renfeng Wang, Fei Guo, Chao Yan. Two-dimensional liquid chromatography coupled with mass spectrometry for the analysis of Lobelia chinensis Lour. using an ESI/APCI multimode ion source. Journal of separation science. 2008 Jul; 31(13):2388-94. doi: 10.1002/jssc.200700685. [PMID: 18604839]
  • Ya-Jun Wang, Xiu-Wwei Yang, Qiao-Sheng Guo. [Studies on chemical constituents in Huangjuhua (flowers of Chrysanthemum morifolium)]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Mar; 33(5):526-30. doi: ". [PMID: 18536375]
  • Guo-liang Chen, Xin-li Li, Ling-gang Shi, Shu-jun Zhang. [Chemical constituents from Cirsium pendulum Fisch. ex DC]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2007 Mar; 30(3):291-4. doi: ". [PMID: 17634035]
  • Qunlin Zhang, Jun Li, Chao Wang, Wei Sun, Zhongtang Zhang, Wenming Cheng. A gradient HPLC method for the quality control of chlorogenic acid, linarin and luteolin in Flos Chrysanthemi Indici suppository. Journal of pharmaceutical and biomedical analysis. 2007 Jan; 43(2):753-7. doi: 10.1016/j.jpba.2006.07.037. [PMID: 16930915]
  • Xu Zhang, Zhou Lan, Xiao-ping Dong, Yun Deng, Xiao-mei Hu, Teng Peng, Ping Guo. [Study on the active components of Nardostachys chinensis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2007 Jan; 30(1):38-41. doi: . [PMID: 17539300]
  • Lu-xin Chen, Hong-yan Ma, Mian Zhang, Chao-feng Zhang, Zheng-tao Wang. [Studies on constituents in herb of Senecio scandens]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 Nov; 31(22):1872-5. doi: ". [PMID: 17285987]
  • Päivi P Oinonen, Jouni K Jokela, Annele I Hatakka, Pia M Vuorela. Linarin, a selective acetylcholinesterase inhibitor from Mentha arvensis. Fitoterapia. 2006 Sep; 77(6):429-34. doi: 10.1016/j.fitote.2006.05.002. [PMID: 16815640]
  • Jian-wei Zeng, Shi-hui Qian, Jin-zhong Wu, Nian-yun Yang. [Studies on involatile constituents of Mentha haplocalyx]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 Mar; 31(5):400-2. doi: ". [PMID: 16711426]
  • Andres Navarrete, Bharathi Avula, Young-Whan Choi, Ikhlas A Khan. Chemical fingerprinting of valeriana species: simultaneous determination of valerenic acids, flavonoids, and phenylpropanoids using liquid chromatography with ultraviolet detection. Journal of AOAC International. 2006 Jan; 89(1):8-15. doi: . [PMID: 16512222]
  • J G Avila Acevedo, C M C Castañeda, F J C Benitez, D A Durán, V R Barroso, C G Martínez, L J L Muñoz, C A Martínez, A Romo de Vivar. Photoprotective activity of Buddleja scordioides. Fitoterapia. 2005 Jun; 76(3-4):301-9. doi: 10.1016/j.fitote.2005.03.009. [PMID: 15890460]
  • Sebastián Fernández, Cristina Wasowski, Alejandro C Paladini, Mariel Marder. Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. Pharmacology, biochemistry, and behavior. 2004 Feb; 77(2):399-404. doi: 10.1016/j.pbb.2003.12.003. [PMID: 14751470]
  • S Rodríguez-Zaragoza, C Ordaz, G Avila, J L Muñoz, A Arciniegas, A Romo de Vivar. In vitro evaluation of the amebicidal activity of Buddleia cordata (Loganiaceae, H.B.K.) on several strains of Acanthamoeba. Journal of ethnopharmacology. 1999 Sep; 66(3):327-34. doi: 10.1016/s0378-8741(98)00186-x. [PMID: 10473180]
  • Y X Shen, L H Quan, L Guan, J M Chen. [Studies on the flavonoids from Dendranthema lavandulifolium]. Yao xue xue bao = Acta pharmaceutica Sinica. 1997 Jun; 32(6):451-4. doi: ". [PMID: 11596327]
  • M Martínez-Vázquez, T O Ramírez Apan, H Aguilar, R Bye. Analgesic and antipyretic activities of an aqueous extract and of the flavone linarin of Buddleia cordata. Planta medica. 1996 Apr; 62(2):137-40. doi: 10.1055/s-2006-957836. [PMID: 8657746]
  • H WAGNER, L HOERHAMMER, W KIRCHNER. [On the additional occurrence of pectolinarin and linarin in the plant kingdom. I. On the Compositae and Papilionaceae flavones]. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft. 1960 Dec; 293/65(?):1053-62. doi: 10.1002/ardp.19602931205. [PMID: 13782492]