Diosmetin (BioDeep_00000000095)

human metabolite PANOMIX_OTCML-2023 Endogenous

代谢物信息卡片

5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one (Diosmetin)

化学式: C16H12O6 (300.06338519999997)
中文名称: 香叶木素
谱图信息: 最多检出来源 Viridiplantae(plant) 4.05%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(cc2=O)c1cc(c(cc1)OC)O)O)O
InChI: InChI=1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3

描述信息

Diosmetin is a monomethoxyflavone that is the 4-methyl ether derivative of luteolin. It is a natural product isolated from citrus fruits which exhibits a range of pharmacological activities. It has a role as an antioxidant, an antineoplastic agent, a plant metabolite, a tropomyosin-related kinase B receptor agonist, an apoptosis inducer, an angiogenesis inhibitor, a cardioprotective agent, a bone density conservation agent, an anti-inflammatory agent and a vasodilator agent. It is a monomethoxyflavone, a trihydroxyflavone and a 3-hydroxyflavonoid. It is functionally related to a luteolin. It is a conjugate acid of a diosmetin-7-olate.
Diosmetin is an O-methylated flavone and the aglycone part of the flavonoid glycosides diosmin that occurs naturally in citrus fruits. Pharmacologically, diosmetin is reported to exhibit anticancer, antimicrobial, antioxidant, oestrogenic and anti-inflamatory activities. It also acts as a weak TrkB receptor agonist.
Diosmetin is a natural product found in Vicia tenuifolia, Salvia tomentosa, and other organisms with data available.
See also: Agathosma betulina leaf (part of).
A monomethoxyflavone that is the 4-methyl ether derivative of luteolin. It is a natural product isolated from citrus fruits which exhibits a range of pharmacological activities.
Isolated from peel of lemon (Citrus limon) and others. Diosmetin is found in many foods, some of which are spearmint, citrus, rosemary, and common thyme.
Diosmetin is found in citrus. Diosmetin is isolated from peel of lemon (Citrus limon) and other
Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.
Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.

同义名列表

42 个代谢物同义名

5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one (Diosmetin); 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-; 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 2-(4-methoxy-3-oxidanyl-phenyl)-5,7-bis(oxidanyl)chromen-4-one; 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-1-benzopyran-4-one; 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one; 5,7-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chromen-4-one; 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone; 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one; ISA KNOX WXII PLUS WHITENING REVOLUTION SERUM; Whoo Gongjinhyang Seol Whitening Jin Essence; Flavone, 3,5,7-trihydroxy-4-methoxy-; Diosmetin (Luteolin 4-methyl ether); 3,5,7-trihydroxy-4-methoxy flavone; 3,5,7-trihydroxy-4-methoxyflavone; 5,7,3-Trihydroxy-4-methoxyflavone; CYANIDENON-4-METHYL ETHER 1479; Diosmetin, analytical standard; MBNGWHIJMBWFHU-UHFFFAOYSA-N; LUTEOLIN-4-METHYL ETHER; Luteolin 4-methyl ether; Salinigricoflavonol; DIOSMETIN [WHO-DD]; Spectrum2_001638; Spectrum4_001113; Spectrum3_000987; Spectrum5_001707; 4-Methylluteolin; DIOSMETIN [INCI]; DIOSMETIN [MI]; DivK1c_006531; KBio2_001985; KBio2_007121; KBio2_004553; KBio1_001475; KBio3_001873; Diosmetine; Diosmetin; DIOSMETOL; Vitamin P; Pillon; J8D

数据库引用编号

24 个数据库交叉引用编号

ChEBI: CHEBI:4630
KEGG: C10038
PubChem: 5281612
HMDB: HMDB0029676
Metlin: METLIN44398
DrugBank: DB11259
ChEMBL: CHEMBL90568
Wikipedia: Diosmetin
LipidMAPS: LMPK12110824
MeSH: diosmetin
ChemIDplus: 0000520343
MetaCyc: CPD-20639
KNApSAcK: C00001036
foodb: FDB000861
chemspider: 4444931
CAS: 520-34-3
medchemexpress: HY-N0125
PMhub: MS000000019
MetaboLights: MTBLC4630
PubChem: 12224
PDB-CCD: J8D
3DMET: B03481
NIKKAJI: J831A
RefMet: Diosmetin

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

168 个相关的物种来源信息

33090 柠檬: -
1276826 Vicia incana: 10.1007/BF00598367
3905 Vicia cracca: 10.1007/BF00598367
3911 Vicia villosa: 10.1007/BF00598367
3908 Vicia sativa: 10.1007/BF00598367
153960 Vicia pisiformis: 10.1007/BF00598367
287754 Vicia dumetorum: 10.1007/BF00598367
200967 Vicia articulata: 10.1007/BF00598367
650620 Vicia monantha: 10.1007/BF00598367
1042229 Vicia tenuifolia: 10.1007/BF00598367
233247 Vicia peregrina: 10.1007/BF00598367
323660 Valeriana amurensis: 10.1007/BF00566097
285591 Tinospora crispa: 10.1016/S0031-9422(03)00076-1
268896 Salvia candidissima:
1933741 Salvia nutans:
49216 Salvia pratensis: 10.1016/S0031-9422(01)00415-0
1249742 Scleria rugosa: 10.1016/S0031-9422(00)84889-X
1914812 Schoenus falcatus: 10.1016/S0031-9422(00)84889-X
37334 Citrus maxima: 10.1016/0021-9673(94)89051-X
85571 Citrus reticulata: 10.1016/0021-9673(94)89051-X
558547 Citrus deliciosa: 10.1016/0021-9673(94)89051-X
55188 Citrus unshiu: 10.1016/0021-9673(94)89051-X
2918710 Daphne aurantiaca: 10.1248/CPB.59.653
4220 Artemisia vulgaris: 10.1021/JF9801264
436195 Arnica chamissonis:
2907093 Heterotheca canescens: 10.1021/NP50021A021
35948 Aeonium glutinosum: 10.1016/0031-9422(93)00074-P
149410 Arnica longifolia: 10.1016/S0031-9422(00)89581-3
143180 Carduus pycnocephalus: 10.1007/BF00598598
267229 Rosa agrestis: 10.1080/14786410903075507
199516 Gutierrezia sarothrae: 10.1515/ZNC-1987-1-212
2500775 Linaria macroura: 10.1007/BF00579788
3808 Acacia: 10.1016/S0031-9422(97)00799-1
65409 Scutellaria baicalensis: 10.1111/J.1600-0609.2009.01365.X
401898 Artemisia gmelinii:
265784 Artemisia iwayomogi:
72347 Artemisia molinieri:
72336 Artemisia caerulescens:
39271 Agastache rugosa: 10.1021/ACS.JNATPROD.9B00697.S001
38868 Salvia officinalis: 10.1021/NP50017A014
1132405 Salvia tomentosa: 10.1021/NP50017A014
282730 Achillea collina:
925377 Aloysia citrodora: 10.1055/S-2006-962505
128002 Tanacetum vulgare: 10.1111/J.2042-7158.1998.TB06924.X
29719 Mentha spicata:
94007 Cnidium monnieri: 10.1021/NP990522W
4132 Eriodictyon californicum: 10.1016/0305-1978(83)90056-X
524209 Taraxacum sinicum: 10.1002/CHIN.200342212
28959 Lupinus texensis: 10.1080/14786419.2010.523423
546409 Satureja cuneifolia: 10.3109/13880208709055202
436208 Arnica nevadensis: 10.1016/0305-1978(84)90032-2
4249 Dubautia arborea: 10.1016/S0305-1978(99)00015-0
1234173 Cyperus alopecuroides: 10.1016/S0031-9422(02)00060-2
2896287 Piptocoma antillana: 10.1016/J.TET.2012.01.061
751879 Ziziphora clinopodioides: 10.1248/CPB.60.397
306395 Micromeria juliana: 10.1016/0305-1978(91)90088-H
306386 Micromeria cristata: 10.1016/0305-1978(91)90088-H
751838 Micromeria croatica: 10.1016/0305-1978(91)90088-H
306391 Micromeria graeca: 10.1016/0305-1978(91)90088-H
996406 Soroseris hookeriana: 10.1055/S-2000-8607
2072400 Tanacetum sinaicum: 10.21608/BFSA.2001.65917
53737 Sphagneticola trilobata: 10.1002/HLCA.201000301
3517 Alnus glutinosa:
46114 Froelichia floridana: 10.1016/J.PHYTOCHEM.2009.01.017
388147 Penstemon gentianoides: 10.1016/J.PHYTOCHEM.2007.03.035
39352 Origanum vulgare:
516546 Cirsium japonicum: 10.1007/S10600-011-9904-6
699700 Lepisorus ussuriensis: 10.1080/14786419.2015.1110702
947117 Valeriana laxiflora: 10.1055/S-2004-827149
2026526 Salvia reptans: 10.1016/0031-9422(91)83644-Z
205374 Artemisia rutifolia: 10.1007/BF00579497
2839963 Zanthoxylum asiaticum: 10.1016/S0031-9422(00)97163-2
146995 Chrysanthemum indicum: 10.1007/BF02857780
2849020 Nepeta tenuifolia: 10.1055/S-2006-961918
948718 Senna sophera: 10.1248/CPB.37.2441
642575 Pedalium murex: 10.1016/S0031-9422(00)90057-8
543980 Thymbra capitata: 10.1016/S0031-9422(00)85533-8
49793 Anagyris foetida: 10.1016/J.FITOTE.2006.06.012
347189 Vicia abbreviata: 10.1007/BF00579492
754109 Vicia cassubica: 10.1007/BF00579492
183227 Anoda cristata: 10.1016/J.JEP.2014.11.052
29655 Zostera marina: 10.1515/BOTM.1995.38.1-6.99
1276826 Vicia incana: 10.1007/BF00598367
3905 Vicia cracca: 10.1007/BF00598367
3911 Vicia villosa: 10.1007/BF00598367
3908 Vicia sativa: 10.1007/BF00598367
153960 Vicia pisiformis: 10.1007/BF00598367
287754 Vicia dumetorum: 10.1007/BF00598367
200967 Vicia articulata: 10.1007/BF00598367
650620 Vicia monantha: 10.1007/BF00598367
1042229 Vicia tenuifolia: 10.1007/BF00598367
233247 Vicia peregrina: 10.1007/BF00598367
323660 Valeriana amurensis: 10.1007/BF00566097
285591 Tinospora crispa: 10.1016/S0031-9422(03)00076-1
268896 Salvia candidissima:
1933741 Salvia nutans:
49216 Salvia pratensis: 10.1016/S0031-9422(01)00415-0
1249742 Scleria rugosa: 10.1016/S0031-9422(00)84889-X
1914812 Schoenus falcatus: 10.1016/S0031-9422(00)84889-X
37334 Citrus maxima: 10.1016/0021-9673(94)89051-X
85571 Citrus reticulata: 10.1016/0021-9673(94)89051-X
558547 Citrus deliciosa: 10.1016/0021-9673(94)89051-X
55188 Citrus unshiu: 10.1016/0021-9673(94)89051-X
2918710 Daphne aurantiaca: 10.1248/CPB.59.653
4220 Artemisia vulgaris: 10.1021/JF9801264
436195 Arnica chamissonis:
2907093 Heterotheca canescens: 10.1021/NP50021A021
35948 Aeonium glutinosum: 10.1016/0031-9422(93)00074-P
149410 Arnica longifolia: 10.1016/S0031-9422(00)89581-3
143180 Carduus pycnocephalus: 10.1007/BF00598598
267229 Rosa agrestis: 10.1080/14786410903075507
199516 Gutierrezia sarothrae: 10.1515/ZNC-1987-1-212
2500775 Linaria macroura: 10.1007/BF00579788
3808 Acacia: 10.1016/S0031-9422(97)00799-1
65409 Scutellaria baicalensis: 10.1111/J.1600-0609.2009.01365.X
401898 Artemisia gmelinii:
265784 Artemisia iwayomogi:
72347 Artemisia molinieri:
72336 Artemisia caerulescens:
39271 Agastache rugosa: 10.1021/ACS.JNATPROD.9B00697.S001
38868 Salvia officinalis: 10.1021/NP50017A014
1132405 Salvia tomentosa: 10.1021/NP50017A014
282730 Achillea collina:
925377 Aloysia citrodora: 10.1055/S-2006-962505
128002 Tanacetum vulgare: 10.1111/J.2042-7158.1998.TB06924.X
29719 Mentha spicata:
94007 Cnidium monnieri: 10.1021/NP990522W
4132 Eriodictyon californicum: 10.1016/0305-1978(83)90056-X
524209 Taraxacum sinicum: 10.1002/CHIN.200342212
28959 Lupinus texensis: 10.1080/14786419.2010.523423
546409 Satureja cuneifolia: 10.3109/13880208709055202
436208 Arnica nevadensis: 10.1016/0305-1978(84)90032-2
4249 Dubautia arborea: 10.1016/S0305-1978(99)00015-0
1234173 Cyperus alopecuroides: 10.1016/S0031-9422(02)00060-2
2896287 Piptocoma antillana: 10.1016/J.TET.2012.01.061
751879 Ziziphora clinopodioides: 10.1248/CPB.60.397
306395 Micromeria juliana: 10.1016/0305-1978(91)90088-H
306386 Micromeria cristata: 10.1016/0305-1978(91)90088-H
751838 Micromeria croatica: 10.1016/0305-1978(91)90088-H
306391 Micromeria graeca: 10.1016/0305-1978(91)90088-H
996406 Soroseris hookeriana: 10.1055/S-2000-8607
2072400 Tanacetum sinaicum: 10.21608/BFSA.2001.65917
53737 Sphagneticola trilobata: 10.1002/HLCA.201000301
3517 Alnus glutinosa:
46114 Froelichia floridana: 10.1016/J.PHYTOCHEM.2009.01.017
388147 Penstemon gentianoides: 10.1016/J.PHYTOCHEM.2007.03.035
39352 Origanum vulgare:
516546 Cirsium japonicum: 10.1007/S10600-011-9904-6
699700 Lepisorus ussuriensis: 10.1080/14786419.2015.1110702
947117 Valeriana laxiflora: 10.1055/S-2004-827149
2026526 Salvia reptans: 10.1016/0031-9422(91)83644-Z
205374 Artemisia rutifolia: 10.1007/BF00579497
2839963 Zanthoxylum asiaticum: 10.1016/S0031-9422(00)97163-2
146995 Chrysanthemum indicum: 10.1007/BF02857780
2849020 Nepeta tenuifolia: 10.1055/S-2006-961918
948718 Senna sophera: 10.1248/CPB.37.2441
642575 Pedalium murex: 10.1016/S0031-9422(00)90057-8
543980 Thymbra capitata: 10.1016/S0031-9422(00)85533-8
49793 Anagyris foetida: 10.1016/J.FITOTE.2006.06.012
347189 Vicia abbreviata: 10.1007/BF00579492
754109 Vicia cassubica: 10.1007/BF00579492
183227 Anoda cristata: 10.1016/J.JEP.2014.11.052
29655 Zostera marina: 10.1515/BOTM.1995.38.1-6.99
9606 Homo sapiens: -
3677 Trichosanthes Kirilowii Maxim: -
354528 Zanthoxylum Nitidum: -
947117 Valeriana laxiflora: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Aihong Yang, Xiaoyue Yi, Hongwei Zhang, Rui Shen, Xiaodi Kou. Diosmetin derivatives as multifunctional anti-AD ligands: Design, synthesis, and biological evaluation. Chemical biology & drug design. 2024 Apr; 103(4):e14529. doi: 10.1111/cbdd.14529. [PMID: 38670598]
Lin Zhao, Xueshu Tao, Qian Wang, Xue Yu, Daosong Dong. Diosmetin alleviates neuropathic pain by regulating the Keap1/Nrf2/NF-κB signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 170(?):116067. doi: 10.1016/j.biopha.2023.116067. [PMID: 38150877]
Huahua Wang, Xiaoyu Zhang, Yangyang Liu, Yunyun Zhang, Yingyu Wang, Yunru Peng, Yongfang Ding. Diosmetin-7-O-β-D-glucopyranoside suppresses endothelial-mesenchymal transformation through endoplasmic reticulum stress in cardiac fibrosis. Clinical and experimental pharmacology & physiology. 2023 Jul; ?(?):. doi: 10.1111/1440-1681.13802. [PMID: 37430476]
Moneerah J Alqahtani, Walaa A Negm, Hebatallah M Saad, Esraa A Salem, Ismail A Hussein, Hanaa A Ibrahim. Fenofibrate and Diosmetin in a rat model of testicular toxicity: New insight on their protective mechanism through PPAR-α/NRF-2/HO-1 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 165(?):115095. doi: 10.1016/j.biopha.2023.115095. [PMID: 37413905]
Faqiang Zhang, Huan Luo. Diosmetin inhibits the growth and invasion of gastric cancer by interfering with M2 phenotype macrophage polarization. Journal of biochemical and molecular toxicology. 2023 Jun; ?(?):e23431. doi: 10.1002/jbt.23431. [PMID: 37377034]
Marcin Feldo, Magdalena Wójciak, Aleksandra Ziemlewska, Sławomir Dresler, Ireneusz Sowa. Modulatory Effect of Diosmin and Diosmetin on Metalloproteinase Activity and Inflammatory Mediators in Human Skin Fibroblasts Treated with Lipopolysaccharide. Molecules (Basel, Switzerland). 2022 Jul; 27(13):. doi: 10.3390/molecules27134264. [PMID: 35807509]
Hai-Long Li, Yi-Ying Wei, Xiao-He Li, Shan-Shan Zhang, Ruo-Tong Zhang, Jin-He Li, Bo-Wei Ma, Shuai-Bo Shao, Zi-Wei Lv, Hao Ruan, Hong-Gang Zhou, Cheng Yang. Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1/Sirt1 axis. Acta pharmacologica Sinica. 2022 Apr; 43(4):919-932. doi: 10.1038/s41401-021-00726-0. [PMID: 34262136]
Zhigang Mei, Lipeng Du, Xiaolu Liu, Xiangyu Chen, Huan Tian, Yihui Deng, Wenli Zhang. Diosmetin alleviated cerebral ischemia/reperfusion injury in vivo and in vitro by inhibiting oxidative stress via the SIRT1/Nrf2 signaling pathway. Food & function. 2022 Jan; 13(1):198-212. doi: 10.1039/d1fo02579a. [PMID: 34881386]
Lianhong Pan, Fan Feng, Jiaqin Wu, Lanqing Li, Haiying Xu, Li Yang, Kang Xu, Chunli Wang. Diosmetin inhibits cell growth and proliferation by regulating the cell cycle and lipid metabolism pathway in hepatocellular carcinoma. Food & function. 2021 Nov; 12(23):12036-12046. doi: 10.1039/d1fo02111g. [PMID: 34755740]
Zhen Wang, Xu Huang, Juan Liu, Feiyao Xiao, Miaomiao Tian, Shenghua Ding, Yang Shan. Screening and heterologous expression of flavone synthase and flavonol synthase to catalyze hesperetin to diosmetin. Biotechnology letters. 2021 Nov; 43(11):2161-2183. doi: 10.1007/s10529-021-03184-0. [PMID: 34514540]
Xiaobao Gong, Li Xiong, Caihong Bi, Baoshun Zhang. Diosmetin ameliorate type 2 diabetic mellitus by up-regulating Corynebacterium glutamicum to regulate IRS/PI3K/AKT-mediated glucose metabolism disorder in KK-Ay mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jul; 87(?):153582. doi: 10.1016/j.phymed.2021.153582. [PMID: 34091150]
Jun Gu Kim, Jin Woo Lee, Thi Phuong Linh Le, Jae Sang Han, Yong Beom Cho, Haeun Kwon, Dongho Lee, Mi Kyeong Lee, Bang Yeon Hwang. Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production. Journal of natural products. 2021 03; 84(3):562-569. doi: 10.1021/acs.jnatprod.0c01121. [PMID: 33667099]
Sariya Meephat, Patoomporn Prasatthong, Siwayu Rattanakanokchai, Sarawoot Bunbupha, Putcharawipa Maneesai, Poungrat Pakdeechote. Diosmetin attenuates metabolic syndrome and left ventricular alterations via the suppression of angiotensin II/AT1 receptor/gp91phox/p-NF-κB protein expression in high-fat diet fed rats. Food & function. 2021 Mar; 12(4):1469-1481. doi: 10.1039/d0fo02744h. [PMID: 33449987]
Nanxuan Luo, Changqing Yang, Yurong Zhu, Qianfeng Chen, Baoshun Zhang. Diosmetin Ameliorates Nonalcoholic Steatohepatitis through Modulating Lipogenesis and Inflammatory Response in a STAT1/CXCL10-Dependent Manner. Journal of agricultural and food chemistry. 2021 Jan; 69(2):655-667. doi: 10.1021/acs.jafc.0c06652. [PMID: 33404223]
Yin-Sheng Quan, Xiao-Yong Zhang, Xiu-Mei Yin, Si-Hong Wang, Li-Li Jin. Potential α-glucosidase inhibitor from Hylotelephium erythrostictum. Bioorganic & medicinal chemistry letters. 2020 12; 30(24):127665. doi: 10.1016/j.bmcl.2020.127665. [PMID: 33152378]
Weiyang Wang, Shimin Zhang, Fan Yang, Jie Xie, Jiajun Chen, Zhanfei Li. Diosmetin alleviates acute kidney injury by promoting the TUG1/Nrf2/HO-1 pathway in sepsis rats. International immunopharmacology. 2020 Nov; 88(?):106965. doi: 10.1016/j.intimp.2020.106965. [PMID: 33182044]
Young Hye Seo, Tuy An Trinh, Seung Mok Ryu, Hyo Seon Kim, Goya Choi, Byeong Cheol Moon, Sang Hee Shim, Dae Sik Jang, Dongho Lee, Ki Sung Kang, Jun Lee. Chemical Constituents from the Aerial Parts of Elsholtzia ciliata and Their Protective Activities on Glutamate-Induced HT22 Cell Death. Journal of natural products. 2020 10; 83(10):3149-3155. doi: 10.1021/acs.jnatprod.0c00756. [PMID: 32991171]
Dezső Csupor, Tibor Kurtán, Martin Vollár, Norbert Kúsz, Katalin E Kövér, Attila Mándi, Péter Szűcs, Marianna Marschall, Seyyed A Senobar Tahaei, István Zupkó, Judit Hohmann. Pigments of the Moss Paraleucobryum longifolium: Isolation and Structure Elucidation of Prenyl-Substituted 8,8'-Linked 9,10-Phenanthrenequinone Dimers. Journal of natural products. 2020 02; 83(2):268-276. doi: 10.1021/acs.jnatprod.9b00655. [PMID: 32077277]
Yuli Yan, Xingyu Liu, Jie Gao, Yin Wu, Yuxin Li. Inhibition of TGF-β Signaling in Gliomas by the Flavonoid Diosmetin Isolated from Dracocephalum peregrinum L. Molecules (Basel, Switzerland). 2020 Jan; 25(1):. doi: 10.3390/molecules25010192. [PMID: 31906574]
Mingning Qiu, Jie Liu, Yongxia Su, Rong Guo, Baoyu Zhao, Jianjun Liu. Diosmetin Induces Apoptosis by Downregulating AKT Phosphorylation via P53 Activation in Human Renal Carcinoma ACHN Cells. Protein and peptide letters. 2020; 27(10):1022-1028. doi: 10.2174/0929866527666200330172646. [PMID: 32223728]
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