Cannflavin A (BioDeep_00000269605)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


6-Geranyl-5,7,4-Trihydroxy-3-methoxyflavone

化学式: C26H28O6 (436.1885788)
中文名称:
谱图信息: 最多检出来源 Astragalus membranaceus(otcml) 66.67%

分子结构信息

SMILES: C1(O)=CC2OC(C3C=C(OC)C(O)=CC=3)=CC(=O)C=2C(O)=C1C/C=C(\C)/CC/C=C(\C)/C
InChI: InChI=1S/C26H28O6/c1-15(2)6-5-7-16(3)8-10-18-20(28)13-24-25(26(18)30)21(29)14-22(32-24)17-9-11-19(27)23(12-17)31-4/h6,8-9,11-14,27-28,30H,5,7,10H2,1-4H3/b16-8+

描述信息

同义名列表

2 个代谢物同义名

Cannflavin A; 6-Geranyl-5,7,4-Trihydroxy-3-methoxyflavone



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Maged S Abdel-Kader, Mohamed M Radwan, Ahmed M Metwaly, Ibrahim H Eissa, Arno Hazekamp, Mahmoud A Sohly. Chemistry and Biological Activities of Cannflavins of the Cannabis Plant. Cannabis and cannabinoid research. 2023 12; 8(6):974-985. doi: 10.1089/can.2023.0128. [PMID: 37756221]
  • Huifang Li, Ni Deng, Tess Puopolo, Xian Jiang, Navindra P Seeram, Chang Liu, Hang Ma. Cannflavins A and B with Anti-Ferroptosis, Anti-Glycation, and Antioxidant Activities Protect Human Keratinocytes in a Cell Death Model with Erastin and Reactive Carbonyl Species. Nutrients. 2023 Oct; 15(21):. doi: 10.3390/nu15214565. [PMID: 37960218]
  • Conor O'Croinin, Tyson S Le, Michael Doschak, Raimar Löbenberg, Neal M Davies. A validated method for detection of cannflavins in hemp extracts. Journal of pharmaceutical and biomedical analysis. 2023 Oct; 235(?):115631. doi: 10.1016/j.jpba.2023.115631. [PMID: 37586306]
  • Simon Erridge, Nagina Mangal, Oliver Salazar, Barbara Pacchetti, Mikael H Sodergren. Cannflavins - From plant to patient: A scoping review. Fitoterapia. 2020 Oct; 146(?):104712. doi: 10.1016/j.fitote.2020.104712. [PMID: 32858172]
  • Luana Izzo, Luigi Castaldo, Alfonso Narváez, Giulia Graziani, Anna Gaspari, Yelko Rodríguez-Carrasco, Alberto Ritieni. Analysis of Phenolic Compounds in Commercial Cannabis sativa L. Inflorescences Using UHPLC-Q-Orbitrap HRMS. Molecules (Basel, Switzerland). 2020 Jan; 25(3):. doi: 10.3390/molecules25030631. [PMID: 32024009]
  • Carly Eggers, Masaya Fujitani, Ryuji Kato, Scott Smid. Novel cannabis flavonoid, cannflavin A displays both a hormetic and neuroprotective profile against amyloid β-mediated neurotoxicity in PC12 cells: Comparison with geranylated flavonoids, mimulone and diplacone. Biochemical pharmacology. 2019 11; 169(?):113609. doi: 10.1016/j.bcp.2019.08.011. [PMID: 31437460]
  • Kevin A Rea, José A Casaretto, M Sameer Al-Abdul-Wahid, Arjun Sukumaran, Jennifer Geddes-McAlister, Steven J Rothstein, Tariq A Akhtar. Biosynthesis of cannflavins A and B from Cannabis sativa L. Phytochemistry. 2019 Aug; 164(?):162-171. doi: 10.1016/j.phytochem.2019.05.009. [PMID: 31151063]
  • Federica Pellati, Virginia Brighenti, Johanna Sperlea, Lucia Marchetti, Davide Bertelli, Stefania Benvenuti. New Methods for the Comprehensive Analysis of Bioactive Compounds in Cannabis sativa L. (hemp). Molecules (Basel, Switzerland). 2018 Oct; 23(10):. doi: 10.3390/molecules23102639. [PMID: 30322208]
  • Tian-Tian Guo, Jian-Chun Zhang, Hai Zhang, Qing-Chao Liu, Yong Zhao, Yu-Fei Hou, Lu Bai, Li Zhang, Xue-Qiang Liu, Xue-Ying Liu, Sheng-Yong Zhang, Nai-Sheng Bai. Bioactive spirans and other constituents from the leaves of Cannabis sativa f. sativa. Journal of Asian natural products research. 2017 Aug; 19(8):793-802. doi: 10.1080/10286020.2016.1248947. [PMID: 27848262]
  • Gianna Allegrone, Federica Pollastro, Gianmaria Magagnini, Orazio Taglialatela-Scafati, Julia Seegers, Andreas Koeberle, Oliver Werz, Giovanni Appendino. The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains. Journal of natural products. 2017 03; 80(3):731-734. doi: 10.1021/acs.jnatprod.6b01126. [PMID: 28165233]
  • Wieland Peschel, Matteo Politi. ¹H NMR and HPLC/DAD for Cannabis sativa L. chemotype distinction, extract profiling and specification. Talanta. 2015 Aug; 140(?):150-165. doi: 10.1016/j.talanta.2015.02.040. [PMID: 26048837]
  • M L Barrett, A M Scutt, F J Evans. Cannflavin A and B, prenylated flavones from Cannabis sativa L. Experientia. 1986 Apr; 42(4):452-3. doi: 10.1007/bf02118655. [PMID: 3754224]
  • M L Barrett, D Gordon, F J Evans. Isolation from Cannabis sativa L. of cannflavin--a novel inhibitor of prostaglandin production. Biochemical pharmacology. 1985 Jun; 34(11):2019-24. doi: 10.1016/0006-2952(85)90325-9. [PMID: 3859295]