5,6,7-Trimethoxyflavone (BioDeep_00000007759)

 

Secondary id: BioDeep_00000395487, BioDeep_00000398500

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


Baicalein 5,6,7-trimethyl ether

化学式: C18H16O5 (312.0997686)
中文名称: 5,6,7-三甲氧基黄酮, 黄岑素-5,6,7-三甲醚
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 1.05%

分子结构信息

SMILES: c1(c(c(c2c(c1)oc(cc2=O)c1ccccc1)OC)OC)OC
InChI: InChI=1S/C18H16O5/c1-20-15-10-14-16(18(22-3)17(15)21-2)12(19)9-13(23-14)11-7-5-4-6-8-11/h4-10H,1-3H3

描述信息

5,6,7-Trimethoxyflavone is a novel p38-α MAPK inhibitor with an anti-inflammatory effect. 5,6,7-Trimethoxyflavone is isolated from several plants including Zeyhera tuberculosa, Callicarpa japonica, and Kickxia lanigera[1].
5,6,7-Trimethoxyflavone is a novel p38-α MAPK inhibitor with an anti-inflammatory effect. 5,6,7-Trimethoxyflavone is isolated from several plants including Zeyhera tuberculosa, Callicarpa japonica, and Kickxia lanigera[1].

同义名列表

4 个代谢物同义名

Baicalein 5,6,7-trimethyl ether; Baicalein-5,6,7-trimethylether; 5,6,7-Trimethoxyflavone; Baicalein trimethyl ether



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nadja Kampschulte, Tim Berking, Ibrahim E Çelik, Stefan F Kirsch, Nils Helge Schebb. Inhibition of cytochrome P450 monooxygenase-catalyzed oxylipin formation by flavonoids: Evaluation of structure-activity relationship towards CYP4F2-selective inhibitors. European journal of medicinal chemistry. 2022 Aug; 238(?):114332. doi: 10.1016/j.ejmech.2022.114332. [PMID: 35576701]
  • Yu-Hsuan Lan, Yann-Lii Leu, Yi-Ting Peng, Tran-Dinh Thang, Chia-Chen Lin, Bo-Ying Bao. The first bis-retrochalcone from Fissistigma latifolium. Planta medica. 2011 Dec; 77(18):2019-22. doi: 10.1055/s-0031-1280088. [PMID: 21850609]
  • Maria Lysete A Bastos, Maria Raquel F Lima, Lucia M Conserva, Vânia S Andrade, Eliana M M Rocha, Rosangela P L Lemos. Studies on the antimicrobial activity and brine shrimp toxicity of Zeyheria tuberculosa (Vell.) Bur. (Bignoniaceae) extracts and their main constituents. Annals of clinical microbiology and antimicrobials. 2009 May; 8(?):16. doi: 10.1186/1476-0711-8-16. [PMID: 19450272]
  • Manuela Saddi, Adriana Sanna, Filippo Cottiglia, Lorenza Chisu, Laura Casu, Leonardo Bonsignore, Alessandro De Logu. Antiherpevirus activity of Artemisia arborescens essential oil and inhibition of lateral diffusion in Vero cells. Annals of clinical microbiology and antimicrobials. 2007 Sep; 6(?):10. doi: 10.1186/1476-0711-6-10. [PMID: 17894898]
  • K Hayashi, T Hayashi, H Otsuka, Y Takeda. Antiviral activity of 5,6,7-trimethoxyflavone and its potentiation of the antiherpes activity of acyclovir. The Journal of antimicrobial chemotherapy. 1997 Jun; 39(6):821-4. doi: 10.1093/jac/39.6.821. [PMID: 9222055]
  • E Liss, A Robertson. The distribution and elimination of radioactivity in the rat after administration of 14C-4-acetamidophenyl-2-acetoxybenzoate (benorylate). Arzneimittel-Forschung. 1975 Nov; 25(11):1792-3. doi: NULL. [PMID: 1051]