Isoscutellarein (BioDeep_00000007875)

human metabolite PANOMIX_OTCML-2023

代谢物信息卡片

5,7,8-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

化学式: C15H10O6 (286.047736)
中文名称: 8-羟基芹菜素
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 8.33%

分子结构信息

SMILES: c1(cc(c2c(c1O)oc(cc2=O)c1ccc(cc1)O)O)O
InChI: InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)12-6-10(18)13-9(17)5-11(19)14(20)15(13)21-12/h1-6,16-17,19-20H

描述信息

同义名列表

4 个代谢物同义名

5,7,8-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4,5,7,8-Tetrahydroxyflavone; 8-Hydroxyapigenin; Isoscutellarein

数据库引用编号

13 个数据库交叉引用编号

ChEBI: CHEBI:6059
KEGG: C10097
PubChem: 5281665
HMDB: HMDB0130166
Metlin: METLIN49785
ChEMBL: CHEMBL1093284
LipidMAPS: LMPK12111361
KNApSAcK: C00003848
CAS: 41440-05-5
PMhub: MS000021382
PubChem: 12283
3DMET: B03537
NIKKAJI: J18.926J

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

66672 - Bixa orellana: 10.1248/CPB.39.3346
9606 - Homo sapiens: -
103974 - Libocedrus bidwillii: 10.1016/0031-9422(90)85105-O
2250722 - Libocedrus chevalieri: 10.1016/0031-9422(90)85105-O
103975 - Libocedrus yateensis: 10.1016/0031-9422(90)85105-O
204352 - Pinguicula fontiqueriana: 10.1016/0031-9422(73)80718-6
204362 - Pinguicula vulgaris: 10.1016/0031-9422(73)80718-6
38868 - Salvia officinalis: 10.1016/S0031-9422(01)00415-0
65409 - Scutellaria baicalensis: 10.1248/YAKUSHI1947.104.5_529
2721167 - Scutellaria immaculata: 10.1007/S10600-005-0068-0
233892 - Scutellaria indica: 10.1248/CPB.37.794
155251 - Sideritis incana: 10.1055/S-2007-969310
1391947 - Stachys aegyptiaca: 10.1007/S10600-007-0186-Y
3897 - Styphnolobium japonicum: 10.1016/S0031-9422(02)00757-4
55496 - Thalassia hemprichii: 10.1007/S10600-014-1040-7

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Marika Mróz, Edyta Malinowska-Pańczyk, Agnieszka Bartoszek, Barbara Kusznierewicz. Comparative Study on Assisted Solvent Extraction Techniques for the Extraction of Biologically Active Compounds from Sideritis raeseri and Sideritis scardica. Molecules (Basel, Switzerland). 2023 May; 28(10):. doi: 10.3390/molecules28104207. [PMID: 37241947]
Khaled Abdelhady Abdelshafeek, Abeer Fouad Osman, Samar Mohamed Mouneir, Ahmed Abdelmonem Elhenawy, Walid Elsayed Abdallah. Phytochemical profile, comparative evaluation of Satureja montana alcoholic extract for antioxidants, anti-inflammatory and molecular docking studies. BMC complementary medicine and therapies. 2023 Apr; 23(1):108. doi: 10.1186/s12906-023-03913-0. [PMID: 37024878]
Qamar Uddin Ahmed, Murni Nazira Sarian, Siti Zaiton Mat So'ad, Jalifah Latip, Solachuddin Jauhari Arief Ichwan, Nurlaili Najmie Hussein, Muhammad Taher, Alhassan Muhammad Alhassan, Hanisuhana Hamidon, Sharida Fakurazi. Methylation and Acetylation Enhanced the Antidiabetic Activity of Some Selected Flavonoids: In Vitro, Molecular Modelling and Structure Activity Relationship-Based Study. Biomolecules. 2018 11; 8(4):. doi: 10.3390/biom8040149. [PMID: 30445784]
Chunying Gao, Hongjian Zhang, Zitao Guo, Tiangeng You, Xiaoyan Chen, Dafang Zhong. Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics. Drug metabolism and disposition: the biological fate of chemicals. 2012 Oct; 40(10):2009-20. doi: 10.1124/dmd.112.047183. [PMID: 22822035]
Vivian Chen, Richard E Staub, Scott Baggett, Ramesh Chimmani, Mary Tagliaferri, Isaac Cohen, Emma Shtivelman. Identification and analysis of the active phytochemicals from the anti-cancer botanical extract Bezielle. PloS one. 2012; 7(1):e30107. doi: 10.1371/journal.pone.0030107. [PMID: 22272282]
Berivan Tandogan, Ayşegül Güvenç, İhsan Çalış, Nuriye Nuray Ulusu. In vitro effects of compounds isolated from Sideritis brevibracteata on bovine kidney cortex glutathione reductase. Acta biochimica Polonica. 2011; 58(4):471-5. doi: . [PMID: 22146136]
Jasmina Petreska, Gjose Stefkov, Svetlana Kulevanova, Kalina Alipieva, Vassya Bankova, Marina Stefova. Phenolic compounds of mountain tea from the Balkans: LC/DAD/ESI/MSn profile and content. Natural product communications. 2011 Jan; 6(1):21-30. doi: . [PMID: 21366039]
Miroslav M Savić, Jelena M Kukić, Renée J Grayer, Marija M Milinković, Petar D Marin, Jovana Divljaković, Michael Van Linn, James M Cook, Silvana D Petrović. Behavioural characterization of four endemic Stachys taxa. Phytotherapy research : PTR. 2010 Sep; 24(9):1309-16. doi: 10.1002/ptr.3106. [PMID: 20127664]
Fumio Matsuda, Keiko Yonekura-Sakakibara, Rie Niida, Takashi Kuromori, Kazuo Shinozaki, Kazuki Saito. MS/MS spectral tag-based annotation of non-targeted profile of plant secondary metabolites. The Plant journal : for cell and molecular biology. 2009 Feb; 57(3):555-77. doi: 10.1111/j.1365-313x.2008.03705.x. [PMID: 18939963]
Bisera Janeska, Marina Stefova, Kalina Alipieva. Assay of flavonoid aglycones from the species of genus Sideritis (Lamiaceae) from Macedonia with HPLC-UV DAD. Acta pharmaceutica (Zagreb, Croatia). 2007 Sep; 57(3):371-7. doi: 10.2478/v10007-007-0030-8. [PMID: 17878116]
Esra Küpeli, F Pinar Sahin, Erdem Yeşilada, Ihsan Caliş, Nurten Ezer. In vivo anti-inflammatory and antinociceptive activity evaluation of phenolic compounds from Sideritis stricta. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2007 Jul; 62(7-8):519-25. doi: 10.1515/znc-2007-7-810. [PMID: 17913066]
Daniela Rigano, Carmen Formisano, Armando Grassia, Gianluca Grassia, Angela Perrone, Sonia Piacente, Maria Luisa Vuotto, Felice Senatore. Antioxidant flavonoids and isoflavonoids from rhizomes of Iris pseudopumila. Planta medica. 2007 Jan; 73(1):93-6. doi: 10.1055/s-2006-957071. [PMID: 17315314]
M Goniotaki, S Hatziantoniou, K Dimas, M Wagner, C Demetzos. Encapsulation of naturally occurring flavonoids into liposomes: physicochemical properties and biological activity against human cancer cell lines. The Journal of pharmacy and pharmacology. 2004 Oct; 56(10):1217-24. doi: 10.1211/0022357044382. [PMID: 15482635]
María José del Baño, Juan Lorente, Julián Castillo, Obdulio Benavente-García, María Piedad Marín, José Antonio Del Río, Ana Ortuño, Isidro Ibarra. Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway. Journal of agricultural and food chemistry. 2004 Aug; 52(16):4987-92. doi: 10.1021/jf040078p. [PMID: 15291464]
Dirk C Albach, Renée J Grayer, Søren Rosendal Jensen, Fevzi Ozgökce, Nigel C Veitch. Acylated flavone glycosides from Veronica. Phytochemistry. 2003 Dec; 64(7):1295-301. doi: 10.1016/j.phytochem.2003.08.012. [PMID: 14599528]
María José del Baño, Juan Lorente, Julián Castillo, Obdulio Benavente-García, José Antonio del Río, Ana Ortuño, Karl-Werner Quirin, Dieter Gerard. Phenolic diterpenes, flavones, and rosmarinic acid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. Antioxidant activity. Journal of agricultural and food chemistry. 2003 Jul; 51(15):4247-53. doi: 10.1021/jf0300745. [PMID: 12848492]
E A Aboutabl, M I Nassar, F M Elsakhawy, Y A Maklad, A F Osman, E A M El-Khrisy. Phytochemical and pharmacological studies on Sideritis taurica Stephan ex Wild. Journal of ethnopharmacology. 2002 Oct; 82(2-3):177-84. doi: 10.1016/s0378-8741(02)00172-1. [PMID: 12241993]
C Lans, T Harper, K Georges, E Bridgewater. Medicinal and ethnoveterinary remedies of hunters in Trinidad. BMC complementary and alternative medicine. 2001; 1(?):10. doi: 10.1186/1472-6882-1-10. [PMID: 11737880]