Morusinol (BioDeep_00000000547)

 

Secondary id: BioDeep_00000270557

human metabolite PANOMIX_OTCML-2023 Endogenous Volatile Flavor Compounds


代谢物信息卡片


2-(2,4-Dihydroxyphenyl)-5-hydroxy-3-(3-hydroxy-3-methylbutyl)-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b]dipyran-4-one, 9CI

化学式: C25H26O7 (438.1678446)
中文名称: 桑根皮醇, 桑树醇
谱图信息: 最多检出来源 Escherichia coli(natural_products) 41.67%

分子结构信息

SMILES: c12cc(c3c(c1C=CC(O2)(C)C)oc(c(c3=O)CCC(C)(C)O)c1ccc(cc1O)O)O
InChI: InChI=1S/C25H26O7/c1-24(2,30)9-7-16-21(29)20-18(28)12-19-15(8-10-25(3,4)32-19)23(20)31-22(16)14-6-5-13(26)11-17(14)27/h5-6,8,10-12,26-28,30H,7,9H2,1-4H3

描述信息

Morusinol is a member of flavones.
Morusinol is a natural product found in Morus lhou, Morus mongolica, and other organisms with data available.
Morusinol is found in fruits. Morusinol is isolated from root bark of Morus alba (white mulberry
Morusinol is a flavonoid isolated from Morus alba root bark. Morusinol has an antiplatelet activity and ?significantly inhibits arterial thrombosis in vivo[1].
Morusinol is a flavonoid isolated from Morus alba root bark. Morusinol has an antiplatelet activity and ?significantly inhibits arterial thrombosis in vivo[1].

同义名列表

17 个代谢物同义名

2-(2,4-Dihydroxyphenyl)-5-hydroxy-3-(3-hydroxy-3-methylbutyl)-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b]dipyran-4-one, 9CI; 4H,8H-BENZO(1,2-B:3,4-B)DIPYRAN-4-ONE, 2-(2,4-DIHYDROXYPHENYL)-5-HYDROXY-3-(3-HYDROXY-3-METHYLBUTYL)-8,8-DIMETHYL-; 2-(2,4-Dihydroxyphenyl)-5-hydroxy-3-(3-hydroxy-3-methylbutyl)-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b]dipyran-4-one; 2-(2,4-Dihydroxy-phenyl)-5-hydroxy-3-(3-hydroxy-3-methyl-butyl)-8,8-dimethyl-8H-benzo(1,2-b:4,3-b)dipyran-4-one; 2-(2,4-Dihydroxy-phenyl)-5-hydroxy-3-(3-hydroxy-3-methyl-butyl)-8,8-dimethyl-8H-benzo[1,2-b:4,3-b]dipyran-4-one; 2-(2,4-Dihydroxyphenyl)-5-hydroxy-3-(3-hydroxy-3-methylbutyl)-8,8-dimethyl-4H,8H-pyrano[2,3-f]chromen-4-one; 2-(2,4-dihydroxyphenyl)-5-hydroxy-3-(3-hydroxy-3-methylbutyl)-8,8-dimethyl-4H,8H-pyrano[2,3-h]chromen-4-one; 2-(2,4-dihydroxyphenyl)-5-hydroxy-3-(3-hydroxy-3-methyl-butyl)-8,8-dimethyl-pyrano[2,3-h]chromen-4-one; 2-(2,4-dihydroxyphenyl)-5-hydroxy-3-(3-hydroxy-3-methylbutyl)-8,8-dimethylpyrano[2,3-h]chromen-4-one; 2-(2,4-DIHYDROXYPHENYL)-5-HYDROXY-3-(3-HYDROXY-3-METHYLBUTYL)-8,8-DIMETHYLPYRANO(2,3-H)CHROMEN-4-ONE; Oxydihydromorusin; Oxydihydromorusi; Oxyhydromorusin; UNII-IA6I4SG21V; IA6I4SG21V; Morusinol; Morusinol



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Li Gao, Yuan-Dong Li, Bao-Kun Zhu, Zhi-Yu Li, Li-Bin Huang, Xian-Yi Li, Fei Wang, Fu-Cai Ren, Tou-Gen Liao. Two new prenylflavonoids from Morus alba. Journal of Asian natural products research. 2018 Feb; 20(2):117-121. doi: 10.1080/10286020.2017.1343303. [PMID: 28644689]
  • Guo-Ying Zuo, Cui-Xian Yang, Jun Han, Yu-Qing Li, Gen-Chun Wang. Synergism of prenylflavonoids from Morus alba root bark against clinical MRSA isolates. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Jan; 39(?):93-99. doi: 10.1016/j.phymed.2017.12.023. [PMID: 29433688]
  • Yu-Ren Liao, Ping-Chung Kuo, Wei-Jern Tsai, Guan-Jhong Huang, Kuo-Hsiung Lee, Tian-Shung Wu. Bioactive chemical constituents from the root bark of Morus australis. Bioorganic & medicinal chemistry letters. 2017 01; 27(2):309-313. doi: 10.1016/j.bmcl.2016.11.046. [PMID: 27908762]
  • Hana Zelová, Zuzana Hanáková, Zuzana Čermáková, Karel Šmejkal, Stefano Dalĺ Acqua, Petr Babula, Josef Cvačka, Jan Hošek. Evaluation of anti-inflammatory activity of prenylated substances isolated from Morus alba and Morus nigra. Journal of natural products. 2014 Jun; 77(6):1297-303. doi: 10.1021/np401025f. [PMID: 24901948]
  • Jung-Jin Lee, Hyun Yang, Yeong-Min Yoo, Seong Su Hong, Dongho Lee, Hyun-Jung Lee, Hak-Ju Lee, Chang-Seon Myung, Kyung-Chul Choi, Eui-Bae Jeung. Morusinol extracted from Morus alba inhibits arterial thrombosis and modulates platelet activation for the treatment of cardiovascular disease. Journal of atherosclerosis and thrombosis. 2012; 19(6):516-22. doi: 10.5551/jat.10058. [PMID: 22472211]
  • Jung Keun Cho, Young Bae Ryu, Marcus J Curtis-Long, Ji Young Kim, Doman Kim, Sun Lee, Woo Song Lee, Ki Hun Park. Inhibition and structural reliability of prenylated flavones from the stem bark of Morus lhou on β-secretase (BACE-1). Bioorganic & medicinal chemistry letters. 2011 May; 21(10):2945-8. doi: 10.1016/j.bmcl.2011.03.060. [PMID: 21511472]
  • Ji Young Kim, Woo Song Lee, Young Soo Kim, Marcus J Curtis-Long, Byong Won Lee, Young Bae Ryu, Ki Hun Park. Isolation of cholinesterase-inhibiting flavonoids from Morus lhou. Journal of agricultural and food chemistry. 2011 May; 59(9):4589-96. doi: 10.1021/jf200423g. [PMID: 21434689]
  • Jiang Du, Zhen-Dan He, Ren-Wang Jiang, Wen-Cai Ye, Hong-Xi Xu, Paul Pui-Hay But. Antiviral flavonoids from the root bark of Morus alba L. Phytochemistry. 2003 Apr; 62(8):1235-8. doi: 10.1016/s0031-9422(02)00753-7. [PMID: 12648543]
  • Mary Beth Leigh, John S Fletcher, Xiong Fu, Frances J Schmitz. Root turnover: an important source of microbial substrates in rhizosphere remediation of recalcitrant contaminants. Environmental science & technology. 2002 Apr; 36(7):1579-83. doi: 10.1021/es015702i. [PMID: 11999069]