Diosmin (BioDeep_00000270488)

Main id: BioDeep_00000000373

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

化学式: C28H32O15 (608.1741122)
中文名称: 地奥司明, 地奥斯明
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 6.45%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(cc2=O)c1ccc(c(c1)O)OC)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)C)O)O)O)O)O)O
InChI: InChI=1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1

描述信息

Diosmin is a disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant and an anti-inflammatory agent. It is a glycosyloxyflavone, a rutinoside, a disaccharide derivative, a monomethoxyflavone and a dihydroxyflavanone. It is functionally related to a diosmetin.
Chronic venous insufficiency is a common condition the western population. Compression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of venous disease. Diosmin is a bioflavonoid isolated from various plants or synthesized from [hesperidin]. It is used for the improvement of capillary fragility or venous insufficiency, including chronic venous insufficiency (CVI) and hemorrhoids. Diosmin is widely available over-the-counter and demonstrates a favourable a favorable safety profile.
Diosmin is a natural product found in Asyneuma argutum, Citrus hystrix, and other organisms with data available.
A bioflavonoid that strengthens vascular walls.
See also: Agathosma betulina leaf (part of).
C - Cardiovascular system > C05 - Vasoprotectives > C05C - Capillary stabilizing agents > C05CA - Bioflavonoids
C26170 - Protective Agent > C275 - Antioxidant > C306 - Bioflavonoid
Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).
Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).

同义名列表

95 个代谢物同义名

5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)methyl)tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one; 5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-chromen-4-one; 5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-7-{[(2S,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-({[(2R,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-METHYLOXAN-2-YL]OXY}METHYL)OXAN-2-YL]OXY}-4H-CHROMEN-4-ONE; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one; 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-; 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-; 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-; 7-((6-O-(6-DEOXY-GA-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; 7-((6-O-(6-Deoxy-ga-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4H-1-benzopyran-7-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside; 4H-1-Benzopyran-4-one,7-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-; 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((6-O-alpha-L-rhamnopyranosyl-beta-D-glycopyranosyl)oxy)-4-chromenon; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(O6-alpha-L-rhamnopyranosyl-beta-D-glucopyranosyloxy)chromen-4-one; 3,5,7-Trihydroxy-4-methoxyflavone-7-(6-O-(-deoxy-alpha-L-mannopyraonsyl)-beta-D-glucopyranoside; Diosmin for system suitability, European Pharmacopoeia (EP) Reference Standard; 3,5-Dihydroxy-4-methoxy-4-oxo-4H-chromen-7-ylrutosid (IUPAC); Diosmin, United States Pharmacopeia (USP) Reference Standard; 3,5-Dihydroxy-4-methoxy-4-oxo-4H-chromen-7-ylrutosid [IUPAC]; Diosmin, European Pharmacopoeia (EP) Reference Standard; 3,5-Dihydroxy-4-methoxy-4-oxo-4H-chromen-7-ylrutosid; 3,5,7-trihydroxy-4-methoxyflavone 7-rhamnoglucoside; 3,5,7-Trihydroxy-4-methoxyflavone 7-rutinoside;; 3,5,7-trihydroxy-4-methoxy flavone-7-rutinoside; 3,5,7-trihydroxy-4-methoxyflavone-7-rutinoside; 3,5,7-Trihydroxy-4-methoxyflavone 7-rutinoside; Luteolin 4-methyl ether 7-rutinoside; Diosmin, analytical standard; Diosmetin-7-O-rutinoside; Diosmetin 7-O-rutinoside; DIOSMIN [EP MONOGRAPH]; Diosmetin 7-rutinoside; DIOSMIN (EP MONOGRAPH); Diosmine [INN-French]; Diosminum [INN-Latin]; Diosmin [INN-Spanish]; Diosmin [INN:BAN]; DIOSMIN (USP-RS); DIOSMIN [WHO-DD]; DIOSMIN [USP-RS]; DIOSMINE [INCI]; UNII-7QM776WJ5N; DIOSMIN [MART.]; DIOSMIN (MART.); Tox21_111392_1; Diosmin [INN]; Diosmin (INN); DIOSMIN [DSC]; Tox21_111392; DIOSMIN [MI]; Resin, Buchu; Diosmin (8); SMP1_000183; Daflon (TN); Buchu Resin; Ven-Detrex; 7QM776WJ5N; Flebosten; Venosmine; Diosminum; Flebavena; flebosmil; Diosmina; Diosmine; Litosmil; Flebaven; Barosmin; Diosimin; Diovenor; Hemerven; Diosmin; Diosmil; Insuven; Varinon; Diosven; C05CA03; Rioven; Dioven; Daflon; Veno-V; Tovene; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-2-tetrahydropyranyl]oxymethyl]-2-tetrahydropyranyl]oxy]-4-chromenone; 5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-chromone; 5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxymethyl]oxan-2-yl]oxy-chromen-4-one; 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.- D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-; EINECS 208-289-7; STOCK1N-14729; AIDS-059330; CCRIS 7915; AIDS059330; 520-27-4; C10039; 5,7,3-Trihydroxy-4-methoxyflavone 7-rhamnosyl- (1->6) -glucoside; 5,7,3-Trihydroxy-4-methoxyflavone 7-O-rutinoside



数据库引用编号

53 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

43 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yinai Deng, Peng Yang, Qianle Zhang, Qingwen Wu, Lingfang Feng, Wenjing Shi, Qian Peng, Li Ding, Xukai Tan, Ruoting Zhan, Dongming Ma. Genomic insights into the evolution of flavonoid biosynthesis and O-methyltransferase and glucosyltransferase in Chrysanthemum indicum. Cell reports. 2024 Jan; 43(2):113725. doi: 10.1016/j.celrep.2024.113725. [PMID: 38300800]
  • Kaushal Vyas, Supraja Prabaker, Dhamodharan Prabhu, Meenakumari Sakthivelu, Sundararaj Rajamanikandan, Palaniyandi Velusamy, Chia-Hung Su, Subash C B Gopinath, Raman Pachaiappan. Study of an inhibitory effect of plant polyphenolic compounds against digestive enzymes using bench-working experimental evidence predicted by molecular docking and dynamics. International journal of biological macromolecules. 2024 Jan; 259(Pt 1):129222. doi: 10.1016/j.ijbiomac.2024.129222. [PMID: 38185307]
  • Jingwei Zhao, Mingming Zhang, Huamin Zhang, Ying Wang, Bingyu Chen, Jing Shao. Diosmin ameliorates LPS-induced depression-like behaviors in mice: Inhibition of inflammation and oxidative stress in the prefrontal cortex. Brain research bulletin. 2024 Jan; 206(?):110843. doi: 10.1016/j.brainresbull.2023.110843. [PMID: 38092305]
  • Clare Njoki Kimani, Helmuth Reuter, Sanet Henriët Kotzé, Pieter Venter, Pritika Ramharack, Christo John Frederick Muller. Pancreatic beta cell regenerative potential of Zanthoxylum chalybeum Engl. Aqueous stem bark extract. Journal of ethnopharmacology. 2023 Nov; ?(?):117374. doi: 10.1016/j.jep.2023.117374. [PMID: 37944876]
  • Mehdi Rahimmalek, Antoni Szumny, Shima Gharibi, Natalia Pachura, Mehran Miroliaei, Jacek Łyczko. Chemical Investigations in Kelussia odoratissima Mozaff. Leaves Based on Comprehensive Analytical Methods: LC-MS, SPME, and GC-MS Analyses. Molecules (Basel, Switzerland). 2023 Aug; 28(16):. doi: 10.3390/molecules28166140. [PMID: 37630391]
  • Marcin Feldo, Magdalena Wójciak, Sławomir Dresler, Paweł Sowa, Bartosz J Płachno, Dariusz Samborski, Ireneusz Sowa. Effect of Diosmin on Selected Parameters of Oxygen Homeostasis. International journal of molecular sciences. 2023 Aug; 24(16):. doi: 10.3390/ijms241612917. [PMID: 37629098]
  • K S Kiran, Vivek Hamse Kameshwar, Kiran Kumar Munakudu-Nagaraju, P Nagalambika, R Kavitha, Avathade Karthick, D Guru Kumar, S Nanjunda Swamy, K L Krishna, J R Kumar. Diosmin: A Daboia russelii venom PLA2s inhibitor- purified, and characterized from Oxalis corniculata L medicinal plant. Journal of ethnopharmacology. 2023 Aug; ?(?):116977. doi: 10.1016/j.jep.2023.116977. [PMID: 37544341]
  • Lukasz Gwozdzinski, Joanna Bernasinska-Slomczewska, Anna Wiktorowska-Owczarek, Edward Kowalczyk, Anna Pieniazek. Diosmin and Bromelain Stimulate Glutathione and Total Thiols Production in Red Blood Cells. Molecules (Basel, Switzerland). 2023 Mar; 28(5):. doi: 10.3390/molecules28052291. [PMID: 36903535]
  • Tarique Anwer, Saeed Alshahrani, Ahmad M H Somaili, Abdullah H Khubrani, Rayan A Ahmed, Abdulmajeed M Jali, Ayed Alshamrani, Hina Rashid, Yousra Nomeir, Mohammad Khalid, Mohammad Firoz Alam. Nephroprotective Effect of Diosmin against Cisplatin-Induced Kidney Damage by Modulating IL-1β, IL-6, TNFα and Renal Oxidative Damage. Molecules (Basel, Switzerland). 2023 Jan; 28(3):. doi: 10.3390/molecules28031302. [PMID: 36770968]
  • Seyed Sajad Hossieni Geshnigani, Masoud Mahdavinia, Mojtaba Kalantar, Mehdi Goudarzi, Layasadat Khorsandi, Hadi Kalantar. Diosmin prophylaxis reduces gentamicin-induced kidney damage in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023 01; 396(1):63-71. doi: 10.1007/s00210-022-02295-3. [PMID: 36121447]
  • Qing-Wen Wu, Min Wei, Ling-Fang Feng, Li Ding, Wu-Ke Wei, Jin-Fen Yang, Xiao-Jing Lin, Hui-Lin Liang, Ruo-Ting Zhan, Dong-Ming Ma. Rhamnosyltransferases involved in the biosynthesis of flavone rutinosides in Chrysanthemum species. Plant physiology. 2022 11; 190(4):2122-2136. doi: 10.1093/plphys/kiac371. [PMID: 35947689]
  • Magdalena Wójciak, Marcin Feldo, Grzegorz Borowski, Tomasz Kubrak, Bartosz J Płachno, Ireneusz Sowa. Antioxidant Potential of Diosmin and Diosmetin against Oxidative Stress in Endothelial Cells. Molecules (Basel, Switzerland). 2022 Nov; 27(23):. doi: 10.3390/molecules27238232. [PMID: 36500323]
  • Johirul Islam, Alpa Shree, Haider Ali Khan, Sarwat Sultana. Chemopreventive potential of Diosmin against benzo[a]pyrene induced lung carcinogenesis in Swiss Albino mice. Journal of biochemical and molecular toxicology. 2022 Nov; 36(11):e23187. doi: 10.1002/jbt.23187. [PMID: 35920545]
  • Piyush Kashyap, Mamta Thakur, Nidhi Singh, Deep Shikha, Shiv Kumar, Poonam Baniwal, Yogender Singh Yadav, Minaxi Sharma, Kandi Sridhar, Baskaran Stephen Inbaraj. In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196374. [PMID: 36234910]
  • Rosa Martha Pérez Gutiérrez, Julio Téllez Gómez, Raúl Borja Urby, José G Contreras Soto, Héctor Romo Parra. Evaluation of Diabetes Effects of Selenium Nanoparticles Synthesized from a Mixture of Luteolin and Diosmin on Streptozotocin-Induced Type 2 Diabetes in Mice. Molecules (Basel, Switzerland). 2022 Sep; 27(17):. doi: 10.3390/molecules27175642. [PMID: 36080407]
  • Hasnaa Osama, Ehdaa O Hamed, Muhammed A Mahmoud, Mohamed E A Abdelrahim. The Effect of Hesperidin and Diosmin Individually or in Combination on Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic Syndrome: A Randomized Controlled Trial. Journal of dietary supplements. 2022 Aug; ?(?):1-14. doi: 10.1080/19390211.2022.2107138. [PMID: 35946912]
  • Marcin Feldo, Magdalena Wójciak, Aleksandra Ziemlewska, Sławomir Dresler, Ireneusz Sowa. Modulatory Effect of Diosmin and Diosmetin on Metalloproteinase Activity and Inflammatory Mediators in Human Skin Fibroblasts Treated with Lipopolysaccharide. Molecules (Basel, Switzerland). 2022 Jul; 27(13):. doi: 10.3390/molecules27134264. [PMID: 35807509]
  • Jiuhong Deng, Chao Zheng, Zhou Hua, Haideng Ci, Guiying Wang, Lijing Chen. Diosmin mitigates high glucose-induced endoplasmic reticulum stress through PI3K/AKT pathway in HK-2 cells. BMC complementary medicine and therapies. 2022 Apr; 22(1):116. doi: 10.1186/s12906-022-03597-y. [PMID: 35477428]
  • Dinesh Kumar, M S Ladaniya, Manju Gurjar, Sunil Kumar. Impact of drying methods on natural antioxidants, phenols and flavanones of immature dropped Citrus sinensis L. Osbeck fruits. Scientific reports. 2022 04; 12(1):6684. doi: 10.1038/s41598-022-10661-7. [PMID: 35461355]
  • Shivani Sharma, Konica Porwal, Chirag Kulkarni, Subhashis Pal, Praveer Sihota, Saroj Kumar, Mahesh Chandra Tiwari, Roshan Katekar, Ashish Kumar, Priya Singh, Swati Rajput, Rajdeep Guha, Navin Kumar, Jiaur R Gayen, Naibedya Chattopadhyay. Diosmin, a citrus fruit-derived phlebotonic bioflavonoid protects rats from chronic kidney disease-induced loss of bone mass and strength without deteriorating the renal function. Food & function. 2022 Feb; 13(4):2184-2199. doi: 10.1039/d1fo03867b. [PMID: 35119062]
  • Samar H Gerges, Sara A Wahdan, Doaa A Elsherbiny, Ebtehal El-Demerdash. Pharmacology of Diosmin, a Citrus Flavone Glycoside: An Updated Review. European journal of drug metabolism and pharmacokinetics. 2022 Jan; 47(1):1-18. doi: 10.1007/s13318-021-00731-y. [PMID: 34687440]
  • Nicolas Monjotin, Guillaume Tenca. Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells. Microvascular research. 2022 01; 139(?):104274. doi: 10.1016/j.mvr.2021.104274. [PMID: 34717967]
  • Sumit Kumar, Prem Prakash Sharma, Charu Upadhyay, Prakasha Kempaiah, Brijesh Rathi, Poonam. Multi-targeting approach for nsp3, nsp9, nsp12 and nsp15 proteins of SARS-CoV-2 by Diosmin as illustrated by molecular docking and molecular dynamics simulation methodologies. Methods (San Diego, Calif.). 2021 11; 195(?):44-56. doi: 10.1016/j.ymeth.2021.02.017. [PMID: 33639316]
  • Merve Yuce, Erdem Cicek, Tugce Inan, Aslihan Basak Dag, Ozge Kurkcuoglu, Fethiye Aylin Sungur. Repurposing of FDA-approved drugs against active site and potential allosteric drug-binding sites of COVID-19 main protease. Proteins. 2021 11; 89(11):1425-1441. doi: 10.1002/prot.26164. [PMID: 34169568]
  • Supaporn Khamchun, Sunisa Yoodee, Visith Thongboonkerd. Dual modulatory effects of diosmin on calcium oxalate kidney stone formation processes: Crystallization, growth, aggregation, crystal-cell adhesion, internalization into renal tubular cells, and invasion through extracellular matrix. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Sep; 141(?):111903. doi: 10.1016/j.biopha.2021.111903. [PMID: 34328112]
  • Azza Fahmy, Gehan Labib Abuelenain, Nesma Rasheed, Amr Abdou. 'de Novo' repurposing of Daflon as anti-intestinal parasitic drug in experimental giardiasis. Experimental parasitology. 2021 Jul; 226-227(?):108124. doi: 10.1016/j.exppara.2021.108124. [PMID: 34139241]
  • Fares E M Ali, Ahmed M Sayed, Ali H El-Bahrawy, Zainab M M Omar, Emad H M Hassanein. Targeting KEAP1/Nrf2, AKT, and PPAR-γ signals as a potential protective mechanism of diosmin against gentamicin-induced nephrotoxicity. Life sciences. 2021 Jun; 275(?):119349. doi: 10.1016/j.lfs.2021.119349. [PMID: 33744325]
  • Muhammet Yasin Tekeli, Gökhan Eraslan, Latife Çakır Bayram, Zeynep Soyer Sarıca. Effect of diosmin on lipid peoxidation and organ damage against subacute deltamethrin exposure in rats. Environmental science and pollution research international. 2021 Apr; 28(13):15890-15908. doi: 10.1007/s11356-020-11277-y. [PMID: 33242198]
  • Michèle Cazaubon, Jean-Patrick Benigni, Marcio Steinbruch, Violaine Jabbour, Christelle Gouhier-Kodas. Is There a Difference in the Clinical Efficacy of Diosmin and Micronized Purified Flavonoid Fraction for the Treatment of Chronic Venous Disorders? Review of Available Evidence. Vascular health and risk management. 2021; 17(?):591-600. doi: 10.2147/vhrm.s324112. [PMID: 34556990]
  • Kushagra Dubey, Raghvendra Dubey, Revathi Gupta, Arun Gupta. Exploration of Diosmin to Control Diabetes and Its Complications-an In Vitro and In Silico Approach. Current computer-aided drug design. 2021; 17(2):307-313. doi: 10.2174/1573409916666200324135734. [PMID: 32208122]
  • Marco Bagnati, Chiara Puricelli, Giulia Bauce, Matteo Basile, Barbara Grigollo, Flavia Prodam, Umberto Dianzani, Giorgio Bellomo, Roberta Rolla. Short-Term Effects of Supplemental L-Arginine, Diosmin, Troxerutin, and Hesperidin in Diabetic Patients: A Pilot Study. BioMed research international. 2021; 2021(?):3508281. doi: 10.1155/2021/3508281. [PMID: 34901269]
  • Cristina García-Iriepa, Cécilia Hognon, Antonio Francés-Monerris, Isabel Iriepa, Tom Miclot, Giampaolo Barone, Antonio Monari, Marco Marazzi. Thermodynamics of the Interaction between the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus-2 and the Receptor of Human Angiotensin-Converting Enzyme 2. Effects of Possible Ligands. The journal of physical chemistry letters. 2020 Nov; 11(21):9272-9281. doi: 10.1021/acs.jpclett.0c02203. [PMID: 33085491]
  • Maria José Martinez-Zapata, Robin Wm Vernooij, Daniel Simancas-Racines, Sonia Maria Uriona Tuma, Airton T Stein, Rosa Maria M Moreno Carriles, Emilio Vargas, Xavier Bonfill Cosp. Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews. 2020 11; 11(?):CD003229. doi: 10.1002/14651858.cd003229.pub4. [PMID: 33141449]
  • Yusuf A Haggag, Nahla E El-Ashmawy, Kamal M Okasha. Is hesperidin essential for prophylaxis and treatment of COVID-19 Infection?. Medical hypotheses. 2020 Nov; 144(?):109957. doi: 10.1016/j.mehy.2020.109957. [PMID: 32531538]
  • Yizhou Zheng, Rui Zhang, Weimei Shi, Linfu Li, Hai Liu, Zhixi Chen, Longhuo Wu. Metabolism and pharmacological activities of the natural health-benefiting compound diosmin. Food & function. 2020 Oct; 11(10):8472-8492. doi: 10.1039/d0fo01598a. [PMID: 32966476]
  • Hendawy Om, Mehrez E El-Naggar, Mona El-Banna, Moustafa M G Fouda, Sarah I Othman, Ahmed A Allam, Osama M Morsy. Combating atherosclerosis with targeted Diosmin nanoparticles-treated experimental diabetes. Investigational new drugs. 2020 10; 38(5):1303-1315. doi: 10.1007/s10637-020-00905-6. [PMID: 32048108]
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