Integrin (BioDeep_00000022536)
Secondary id: BioDeep_00000270340
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
2-(2,4-Dihydroxyphenyl)-5-hydroxy-7-methoxy-3-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
化学式: C21H20O6 (368.125982)
中文名称:
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 7.89%
分子结构信息
SMILES: CC(=CCC1=C(OC2=CC(=CC(=C2C1=O)O)OC)C3=C(C=C(C=C3)O)O)C
InChI: InChI=1S/C21H20O6/c1-11(2)4-6-15-20(25)19-17(24)9-13(26-3)10-18(19)27-21(15)14-7-5-12(22)8-16(14)23/h4-5,7-10,22-24H,6H2,1-3H3
描述信息
Integrin is found in fruits. Integrin is a constituent of heartwood of Artocarpus integer (champeduk)
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- PubChem: 44258291
- HMDB: HMDB0029486
- Wikipedia: Integrin
- KNApSAcK: C00004031
- foodb: FDB000618
- chemspider: 24843901
- CAS: 60791-49-3
- PMhub: MS000088275
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 3490 Artocarpus integer: 10.1002/CHIN.197628343
- 3490 Artocarpus integer: 10.1002/CHIN.197628343
- 9606 Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ping Hu, Bing-Hao Luo. Integrin bi-directional signaling across the plasma membrane.
Journal of cellular physiology.
2013 Feb; 228(2):306-12. doi:
10.1002/jcp.24154. [PMID: 22767296] - Hye-Ryung Choi, Youn-A Kang, Sun-Jong Ryoo, Jung-Won Shin, Jung-Im Na, Chang-Hun Huh, Kyoung-Chan Park. Stem cell recovering effect of copper-free GHK in skin.
Journal of peptide science : an official publication of the European Peptide Society.
2012 Nov; 18(11):685-90. doi:
10.1002/psc.2455. [PMID: 23019153] - Balajikarthick Subramanian, Wei-Che Ko, Vikas Yadav, Teresa M DesRochers, Ronald D Perrone, Jing Zhou, David L Kaplan. The regulation of cystogenesis in a tissue engineered kidney disease system by abnormal matrix interactions.
Biomaterials.
2012 Nov; 33(33):8383-94. doi:
10.1016/j.biomaterials.2012.08.020. [PMID: 22940218] - Zhen-Gao Sun, Fang Lian, Qing Jia, Jin-Long Sun, Ting-Ting Li, Ying Guo, Jian-Wei Zhang, Ning Zhang, Hui Liu, Li-Hong Wang. Effects of Er'zhi Tiangui Granule () on sequential expressions of integrin β 3 and its ligand osteopontin in mouse endometrium during controlled ovarian hyperstimulation.
Chinese journal of integrative medicine.
2012 Nov; 18(11):846-9. doi:
10.1007/s11655-012-1273-7. [PMID: 23086489] - Ronghua Zhao, Luca Quaroni, Alan G Casson. Identification and characterization of stemlike cells in human esophageal adenocarcinoma and normal epithelial cell lines.
The Journal of thoracic and cardiovascular surgery.
2012 Nov; 144(5):1192-9. doi:
10.1016/j.jtcvs.2012.08.008. [PMID: 22980068] - Domenico Alloatti, Giuseppe Giannini, Loredana Vesci, Massimo Castorina, Claudio Pisano, Elena Badaloni, Walter Cabri. Camptothecins in tumor homing via an RGD sequence mimetic.
Bioorganic & medicinal chemistry letters.
2012 Oct; 22(20):6509-12. doi:
10.1016/j.bmcl.2012.07.061. [PMID: 22959246] - Jung-Jin Park, Seon-Mi Seo, Eun Ju Kim, Yoon-Jin Lee, Young-Gyu Ko, Joohun Ha, Minyoung Lee. Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin β1 signaling.
Biochemical and biophysical research communications.
2012 Oct; 426(4):461-7. doi:
10.1016/j.bbrc.2012.08.091. [PMID: 22943849] - Paola E J van der Meijden, Marion A H Feijge, Frauke Swieringa, Karen Gilio, Reyhan Nergiz-Unal, Karly Hamulyák, Johan W M Heemskerk. Key role of integrin α(IIb)β (3) signaling to Syk kinase in tissue factor-induced thrombin generation.
Cellular and molecular life sciences : CMLS.
2012 Oct; 69(20):3481-92. doi:
10.1007/s00018-012-1033-2. [PMID: 22669259] - Jae Hong Park, Jung Min Ryu, Seung Pil Yun, Mi Ok Kim, Ho Jae Han. Fibronectin stimulates migration through lipid raft dependent NHE-1 activation in mouse embryonic stem cells: involvement of RhoA, Ca(2+)/CaM, and ERK.
Biochimica et biophysica acta.
2012 Oct; 1820(10):1618-27. doi:
10.1016/j.bbagen.2012.05.013. [PMID: 22683701] - Chiara Sandri, Francesca Caccavari, Donatella Valdembri, Chiara Camillo, Stefan Veltel, Martina Santambrogio, Letizia Lanzetti, Federico Bussolino, Johanna Ivaska, Guido Serini. The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling.
Cell research.
2012 Oct; 22(10):1479-501. doi:
10.1038/cr.2012.110. [PMID: 22825554] - Xinming Su, Desiree H Floyd, Alun Hughes, Jingyu Xiang, Jochen G Schneider, Ozge Uluckan, Emanuela Heller, Hongju Deng, Wei Zou, Clarissa S Craft, Kaiming Wu, Angela C Hirbe, Dorota Grabowska, Mark C Eagleton, Sarah Townsley, Lynne Collins, David Piwnica-Worms, Thomas H Steinberg, Deborah V Novack, Pamela B Conley, Michelle A Hurchla, Michael Rogers, Katherine N Weilbaecher. The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.
The Journal of clinical investigation.
2012 Oct; 122(10):3579-92. doi:
10.1172/jci38576. [PMID: 22996695] - Bernhard Wehrle-Haller. Assembly and disassembly of cell matrix adhesions.
Current opinion in cell biology.
2012 Oct; 24(5):569-81. doi:
10.1016/j.ceb.2012.06.010. [PMID: 22819514] - Wen-Chao Ou, Hai-Feng Chen, Yun Zhong, Ben-Rong Liu, Shi-Ming Liu, Ke-Ji Chen. Inhibition of platelet activation and aggregation by furostanol saponins isolated from the bulbs of Allium macrostemon Bunge.
The American journal of the medical sciences.
2012 Oct; 344(4):261-7. doi:
10.1097/maj.0b013e31823ea9f0. [PMID: 22222335] - Wei-Shan Hung, Chien-Ling Huang, Jui-Ting Fan, Ding-Yuan Huang, Chun-Fung Yeh, Ju-Chien Cheng, Ching-Ping Tseng. The endocytic adaptor protein Disabled-2 is required for cellular uptake of fibrinogen.
Biochimica et biophysica acta.
2012 Oct; 1823(10):1778-88. doi:
10.1016/j.bbamcr.2012.06.008. [PMID: 22705885] - Bei Zhou, Xiuli Xiao, Lili Xu, Lian Zhu, Liang Tan, Hao Tang, Youyu Zhang, Qingji Xie, Shouzhuo Yao. Electrochemical immunoassay on expression of integrin β1 on tumor cells and drug-resistant tumor cells.
Biosensors & bioelectronics.
2012 Oct; 38(1):389-95. doi:
10.1016/j.bios.2012.06.040. [PMID: 22776180] - Jung Hwa Park, Christine E Wasilewski, Noelia Almodovar, Rene Olivares-Navarrete, Barbara D Boyan, Rina Tannenbaum, Zvi Schwartz. The responses to surface wettability gradients induced by chitosan nanofilms on microtextured titanium mediated by specific integrin receptors.
Biomaterials.
2012 Oct; 33(30):7386-93. doi:
10.1016/j.biomaterials.2012.06.066. [PMID: 22835642] - Sariah Khormaee, Omar A Ali, James Chodosh, David J Mooney. Optimizing siRNA efficacy through alteration in the target cell-adhesion substrate interaction.
Journal of biomedical materials research. Part A.
2012 Oct; 100(10):2637-43. doi:
10.1002/jbm.a.34202. [PMID: 22615234] - Tamina Seeger-Nukpezah, Erica A Golemis. The extracellular matrix and ciliary signaling.
Current opinion in cell biology.
2012 Oct; 24(5):652-61. doi:
10.1016/j.ceb.2012.06.002. [PMID: 22819513] - Cécile Boscher, Yu Zi Zheng, Ramya Lakshminarayan, Ludger Johannes, James W Dennis, Leonard J Foster, Ivan R Nabi. Galectin-3 protein regulates mobility of N-cadherin and GM1 ganglioside at cell-cell junctions of mammary carcinoma cells.
The Journal of biological chemistry.
2012 Sep; 287(39):32940-52. doi:
10.1074/jbc.m112.353334. [PMID: 22846995] - Alex H Babayan, Enikö A Kramár, Ruth M Barrett, Matiar Jafari, Jakob Häettig, Lulu Y Chen, Christopher S Rex, Julie C Lauterborn, Marcelo A Wood, Christine M Gall, Gary Lynch. Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012 Sep; 32(37):12854-61. doi:
10.1523/jneurosci.2024-12.2012. [PMID: 22973009] - Radim Moravec, Kathryn K Conger, Ryan D'Souza, Anne B Allison, James E Casanova. BRAG2/GEP100/IQSec1 interacts with clathrin and regulates α5β1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5).
The Journal of biological chemistry.
2012 Sep; 287(37):31138-47. doi:
10.1074/jbc.m112.383117. [PMID: 22815487] - Ying Chen, William Rice, Zhizhan Gu, Jian Li, Jianmin Huang, Michael B Brenner, Alfred Van Hoek, Jianping Xiong, Gregg G Gundersen, Jim C Norman, Victor W Hsu, Robert A Fenton, Dennis Brown, Hua A Jenny Lu. Aquaporin 2 promotes cell migration and epithelial morphogenesis.
Journal of the American Society of Nephrology : JASN.
2012 Sep; 23(9):1506-17. doi:
10.1681/asn.2012010079. [PMID: 22859853] - Samir Jawhara, Elzbieta Pluskota, Dmitriy Verbovetskiy, Olena Skomorovska-Prokvolit, Edward F Plow, Dmitry A Soloviev. Integrin αXβ₂ is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.
Journal of immunology (Baltimore, Md. : 1950).
2012 Sep; 189(5):2468-77. doi:
10.4049/jimmunol.1200524. [PMID: 22844116] - Severine Tabone-Eglinger, Monique Wehrle-Haller, Nicole Aebischer, Marie-Claude Jacquier, Bernhard Wehrle-Haller. Membrane-bound Kit ligand regulates melanocyte adhesion and survival, providing physical interaction with an intraepithelial niche.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2012 Sep; 26(9):3738-53. doi:
10.1096/fj.12-206045. [PMID: 22637532] - Hung-Yun Lin, Heng Yuan Tang, Faith B Davis, Shaker A Mousa, Sandra Incerpi, Mary K Luidens, Ran Meng, Paul J Davis. Nongenomic regulation by thyroid hormone of plasma membrane ion and small molecule pumps.
Discovery medicine.
2012 Sep; 14(76):199-206. doi:
NULL. [PMID: 23021374] - Shigeki Suzuki, Naoto Haruyama, Fusanori Nishimura, Ashok B Kulkarni. Dentin sialophosphoprotein and dentin matrix protein-1: Two highly phosphorylated proteins in mineralized tissues.
Archives of oral biology.
2012 Sep; 57(9):1165-75. doi:
10.1016/j.archoralbio.2012.03.005. [PMID: 22534175] - Youn-Kwan Jung, Seung-Woo Han, Gun-Woo Kim, Jae-Hwan Jeong, Hyun-Ju Kim, Je-Yong Choi. DICAM inhibits osteoclast differentiation through attenuation of the integrin αVβ3 pathway.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2012 Sep; 27(9):2024-34. doi:
10.1002/jbmr.1632. [PMID: 22492581] - Emmanouil Kyriakakis, Kseniya Maslova, Maria Philippova, Dennis Pfaff, Manjunath B Joshi, Stanislaw A Buechner, Paul Erne, Thérèse J Resink. T-Cadherin is an auxiliary negative regulator of EGFR pathway activity in cutaneous squamous cell carcinoma: impact on cell motility.
The Journal of investigative dermatology.
2012 Sep; 132(9):2275-85. doi:
10.1038/jid.2012.131. [PMID: 22592160] - Wenfu Zheng, Yunyan Xie, Wei Zhang, Dong Wang, Wanshun Ma, Zhuo Wang, Xingyu Jiang. Fluid flow stress induced contraction and re-spread of mesenchymal stem cells: a microfluidic study.
Integrative biology : quantitative biosciences from nano to macro.
2012 Sep; 4(9):1102-11. doi:
10.1039/c2ib20094e. [PMID: 22814412] - Lisann Pelzl, Alexander Tolios, Eva-Maria Schmidt, Ioana Alesutan, Britta Walker, Patrick Münzer, Oliver Borst, Meinrad Gawaz, Florian Lang. Translational regulation of the serum- and glucocorticoid-inducible kinase-1 (SGK1) in platelets.
Biochemical and biophysical research communications.
2012 Aug; 425(1):1-5. doi:
10.1016/j.bbrc.2012.07.026. [PMID: 22809514] - Krista A Riggs, Nazarul Hasan, David Humphrey, Christy Raleigh, Chris Nevitt, Deborah Corbin, Chuan Hu. Regulation of integrin endocytic recycling and chemotactic cell migration by syntaxin 6 and VAMP3 interaction.
Journal of cell science.
2012 Aug; 125(Pt 16):3827-39. doi:
10.1242/jcs.102566. [PMID: 22573826] - Vanesa Freire, Noelia Andollo, Jaime Etxebarria, Juan A Durán, María-Celia Morales. In vitro effects of three blood derivatives on human corneal epithelial cells.
Investigative ophthalmology & visual science.
2012 Aug; 53(9):5571-8. doi:
10.1167/iovs.11-7340. [PMID: 22786903] - Zoltan Dekan, Ching-I Anderson Wang, Robert K Andrews, Richard J Lewis, Paul F Alewood. Conotoxin engineering: dual pharmacophoric noradrenaline transport inhibitor/integrin binding peptide with improved stability.
Organic & biomolecular chemistry.
2012 Aug; 10(30):5791-4. doi:
10.1039/c2ob25133g. [PMID: 22581211] - Paresma R Patel, Rosemary Conrad Kiser, Ying Y Lu, Eileen Fong, Wilson C Ho, David A Tirrell, Robert H Grubbs. Synthesis and cell adhesive properties of linear and cyclic RGD functionalized polynorbornene thin films.
Biomacromolecules.
2012 Aug; 13(8):2546-53. doi:
10.1021/bm300795y. [PMID: 22783892] - Chun Chen, Makoto Kudo, Florentine Rutaganira, Hiromi Takano, Candace Lee, Amha Atakilit, Kathryn S Robinett, Toshimitsu Uede, Paul J Wolters, Kevan M Shokat, Xiaozhu Huang, Dean Sheppard. Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.
The Journal of clinical investigation.
2012 Aug; 122(8):2916-27. doi:
10.1172/jci60387. [PMID: 22772469] - Paolo De Vito, Valentina Balducci, Stefano Leone, Zulema Percario, Giorgio Mangino, Paul J Davis, Faith B Davis, Elisabetta Affabris, Paolo Luly, Jens Z Pedersen, Sandra Incerpi. Nongenomic effects of thyroid hormones on the immune system cells: New targets, old players.
Steroids.
2012 Aug; 77(10):988-95. doi:
10.1016/j.steroids.2012.02.018. [PMID: 22414628] - Keiko Kawauchi, Wee Wee Tan, Keigo Araki, Farhana Binte Abu Bakar, Minsoo Kim, Hideaki Fujita, Hiroaki Hirata, Yasuhiro Sawada. p130Cas-dependent actin remodelling regulates myogenic differentiation.
The Biochemical journal.
2012 Aug; 445(3):323-32. doi:
10.1042/bj20112169. [PMID: 22587391] - Alexander Zheleznyak, Thaddeus J Wadas, Christopher D Sherman, Jessica M Wilson, Paul J Kostenuik, Katherine N Weilbaecher, Carolyn J Anderson. Integrin α(v)β₃ as a PET imaging biomarker for osteoclast number in mouse models of negative and positive osteoclast regulation.
Molecular imaging and biology.
2012 Aug; 14(4):500-8. doi:
10.1007/s11307-011-0512-4. [PMID: 21853370] - Avraham Halperin, Martin Kröger. Theoretical considerations on mechanisms of harvesting cells cultured on thermoresponsive polymer brushes.
Biomaterials.
2012 Jul; 33(20):4975-87. doi:
10.1016/j.biomaterials.2012.03.060. [PMID: 22502791] - Leila Choucha Snouber, Sébastien Jacques, Matthieu Monge, Cécile Legallais, Eric Leclerc. Transcriptomic analysis of the effect of ifosfamide on MDCK cells cultivated in microfluidic biochips.
Genomics.
2012 Jul; 100(1):27-34. doi:
10.1016/j.ygeno.2012.05.001. [PMID: 22580237] - M Bhattacharya, G Su, X Su, J A Oses-Prieto, J T Li, X Huang, H Hernandez, A Atakilit, A L Burlingame, M A Matthay, D Sheppard. IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia.
American journal of physiology. Lung cellular and molecular physiology.
2012 Jul; 303(1):L12-9. doi:
10.1152/ajplung.00375.2011. [PMID: 22561460] - Monowar Aziz, Akihisa Matsuda, Weng-Lang Yang, Asha Jacob, Ping Wang. Milk fat globule-epidermal growth factor-factor 8 attenuates neutrophil infiltration in acute lung injury via modulation of CXCR2.
Journal of immunology (Baltimore, Md. : 1950).
2012 Jul; 189(1):393-402. doi:
10.4049/jimmunol.1200262. [PMID: 22634615] - Hee Doo Lee, Bon-Hun Koo, Yeon Hyang Kim, Ok-Hee Jeon, Doo-Sik Kim. Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2012 Jul; 26(7):3084-95. doi:
10.1096/fj.11-201681. [PMID: 22505472] - Lisa Kurtz, Liyo Kao, Debra Newman, Ira Kurtz, Quansheng Zhu. Integrin αIIbβ3 inside-out activation: an in situ conformational analysis reveals a new mechanism.
The Journal of biological chemistry.
2012 Jun; 287(27):23255-65. doi:
10.1074/jbc.m112.360966. [PMID: 22613710] - Matthew T Rondina, BreAnna Brewster, Colin K Grissom, Guy A Zimmerman, Diana H Kastendieck, Estelle S Harris, Andrew S Weyrich. In vivo platelet activation in critically ill patients with primary 2009 influenza A(H1N1).
Chest.
2012 Jun; 141(6):1490-1495. doi:
10.1378/chest.11-2860. [PMID: 22383669] - Suzanne Sander, Neha Arora, Emily A Smith. Elucidating the role of select cytoplasmic proteins in altering diffusion of integrin receptors.
Analytical and bioanalytical chemistry.
2012 Jun; 403(8):2327-37. doi:
10.1007/s00216-011-5603-1. [PMID: 22234402] - Moonmoon Deb, Dipta Sengupta, Samir Kumar Patra. Integrin-epigenetics: a system with imperative impact on cancer.
Cancer metastasis reviews.
2012 Jun; 31(1-2):221-34. doi:
10.1007/s10555-011-9341-9. [PMID: 22160755] - Akihiro C E Shibata, Takahiro K Fujiwara, Limin Chen, Kenichi G N Suzuki, Yoshiro Ishikawa, Yuri L Nemoto, Yoshihiro Miwa, Ziya Kalay, Rahul Chadda, Keiji Naruse, Akihiro Kusumi. Archipelago architecture of the focal adhesion: membrane molecules freely enter and exit from the focal adhesion zone.
Cytoskeleton (Hoboken, N.J.).
2012 Jun; 69(6):380-92. doi:
10.1002/cm.21032. [PMID: 22488960] - Triantafyllos Chavakis. Leucocyte recruitment in inflammation and novel endogenous negative regulators thereof.
European journal of clinical investigation.
2012 Jun; 42(6):686-91. doi:
10.1111/j.1365-2362.2012.02677.x. [PMID: 22577952] - Larissa Kerecuk, David A Long, Zahabia Ali, Corina Anders, Maria Kolatsi-Joannou, Peter J Scambler, Adrian S Woolf. Expression of Fraser syndrome genes in normal and polycystic murine kidneys.
Pediatric nephrology (Berlin, Germany).
2012 Jun; 27(6):991-8. doi:
10.1007/s00467-012-2100-5. [PMID: 21993971] - Bruce E Rapuano, Jani J E Lee, Daniel E MacDonald. Titanium alloy surface oxide modulates the conformation of adsorbed fibronectin to enhance its binding to α(5) β(1) integrins in osteoblasts.
European journal of oral sciences.
2012 Jun; 120(3):185-94. doi:
10.1111/j.1600-0722.2012.954.x. [PMID: 22607334] - Ling Yu, Yan Su, Paisit Paueksakon, Huifang Cheng, Xiwu Chen, Hongtao Wang, Raymond C Harris, Roy Zent, Ambra Pozzi. Integrin α1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy.
Kidney international.
2012 Jun; 81(11):1086-97. doi:
10.1038/ki.2011.474. [PMID: 22297672] - Yi-cheng Jian, Wei Li, Yi He, Ming Jiang, Yan-bing Liu, Wu-jun Xiong. Effect of oxymatrine on hepatic gene expression profile in experimental liver fibrosis of rats.
Chinese journal of integrative medicine.
2012 Jun; 18(6):445-50. doi:
10.1007/s11655-012-1115-x. [PMID: 22821657] - Kristen K McCampbell, Rebecca A Wingert. Renal stem cells: fact or science fiction?.
The Biochemical journal.
2012 Jun; 444(2):153-68. doi:
10.1042/bj20120176. [PMID: 22574774] - Arnaud Briat, Christiane H F Wenk, Mitra Ahmadi, Michael Claron, Didier Boturyn, Véronique Josserand, Pascal Dumy, Daniel Fagret, Jean-Luc Coll, Catherine Ghezzi, Lucie Sancey, Jean-Philippe Vuillez. Reduction of renal uptake of 111In-DOTA-labeled and A700-labeled RAFT-RGD during integrin αvβ3 targeting using single photon emission computed tomography and optical imaging.
Cancer science.
2012 Jun; 103(6):1105-10. doi:
10.1111/j.1349-7006.2012.02286.x. [PMID: 22448775] - Corina M Borza, Yan Su, Xiwu Chen, Ling Yu, Stacey Mont, Sergei Chetyrkin, Paul Voziyan, Billy G Hudson, Paul C Billings, Hyunil Jo, Joel S Bennett, William F Degrado, Beate Eckes, Roy Zent, Ambra Pozzi. Inhibition of integrin α2β1 ameliorates glomerular injury.
Journal of the American Society of Nephrology : JASN.
2012 Jun; 23(6):1027-38. doi:
10.1681/asn.2011040367. [PMID: 22440900] - Krisztina Futosi, Tamás Németh, Robert Pick, Tibor Vántus, Barbara Walzog, Attila Mócsai. Dasatinib inhibits proinflammatory functions of mature human neutrophils.
Blood.
2012 May; 119(21):4981-91. doi:
10.1182/blood-2011-07-369041. [PMID: 22411867] - Qiyuan Zhou, Tianji Chen, Joyce Christina F Ibe, J Usha Raj, Guofei Zhou. Knockdown of von Hippel-Lindau protein decreases lung cancer cell proliferation and colonization.
FEBS letters.
2012 May; 586(10):1510-5. doi:
10.1016/j.febslet.2012.04.009. [PMID: 22673518] - Miriam Stoeber, Ina Karen Stoeck, Christine Hänni, Christopher Karl Ernst Bleck, Giuseppe Balistreri, Ari Helenius. Oligomers of the ATPase EHD2 confine caveolae to the plasma membrane through association with actin.
The EMBO journal.
2012 May; 31(10):2350-64. doi:
10.1038/emboj.2012.98. [PMID: 22505029] - Nikolay L Malinin, Elzbieta Pluskota, Tatiana V Byzova. Integrin signaling in vascular function.
Current opinion in hematology.
2012 May; 19(3):206-11. doi:
10.1097/moh.0b013e3283523df0. [PMID: 22488305] - Jung Mi Kang, Min Han, In Su Park, Youngmee Jung, Soo Hyun Kim, Sang-Heon Kim. Adhesion and differentiation of adipose-derived stem cells on a substrate with immobilized fibroblast growth factor.
Acta biomaterialia.
2012 May; 8(5):1759-67. doi:
10.1016/j.actbio.2012.01.005. [PMID: 22285427] - Chien-An Chen, Yu-Chi Cheng, Jyh-Chang Hwang, Jer-Ming Chang, Jinn-Yuh Guh, Hung-Chun Chen. Cyclin D1 expression in podocytes: regulated by mitogens in collaboration with integrin-extracellular matrix interaction through extracellular signal-regulated kinase.
Experimental biology and medicine (Maywood, N.J.).
2012 May; 237(5):516-23. doi:
10.1258/ebm.2012.011156. [PMID: 22678010] - Ying-Xue Li, Qiang Sun, Hui Zhang, Shu-Ting Ren, Yi-Ran Liao, Ya Wang, Xin-Liang Shen, Bing Wang. A novel anti-platelet peptide (Z4A5) potential for glycoprotein IIb/IIIa inhibits platelet aggregation.
Thrombosis research.
2012 May; 129(5):e217-22. doi:
10.1016/j.thromres.2012.02.047. [PMID: 22445430] - Mohan Doss, Hartmuth C Kolb, James J Zhang, Marie-José Bélanger, James B Stubbs, Michael G Stabin, Eric D Hostetler, R Katherine Alpaugh, Margaret von Mehren, Joseph C Walsh, Michael Haka, Vani P Mocharla, Jian Q Yu. Biodistribution and radiation dosimetry of the integrin marker 18F-RGD-K5 determined from whole-body PET/CT in monkeys and humans.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2012 May; 53(5):787-95. doi:
10.2967/jnumed.111.088955. [PMID: 22499613] - Davide Gnocchi, Silvia Leoni, Sandra Incerpi, Giovannella Bruscalupi. 3,5,3'-triiodothyronine (T3) stimulates cell proliferation through the activation of the PI3K/Akt pathway and reactive oxygen species (ROS) production in chick embryo hepatocytes.
Steroids.
2012 May; 77(6):589-95. doi:
10.1016/j.steroids.2012.01.022. [PMID: 22366194] - Kerstin Amann, Christian S Haas, Julian Schüssler, Christoph Daniel, Andrea Hartner, Harald O Schöcklmann. Beneficial effects of integrin αvβ3-blocking RGD peptides in early but not late phase of experimental glomerulonephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2012 May; 27(5):1755-68. doi:
10.1093/ndt/gfr603. [PMID: 22049183] - Young-Ok Son, Young-Mi Jeon, Yu-Shin Kim, Soon-Sun Park, Seung-Moon Park, Ji-Hae Kim, Jeong-Chae Lee. Streptococcus mutans GS-5 antigen I/II stimulates cell survival in serum deprived-cultures through PI3K/Akt pathways.
Journal of cellular biochemistry.
2012 May; 113(5):1724-32. doi:
10.1002/jcb.24042. [PMID: 22213029] - Cheng-han Yu, Weiwei Luo, Michael P Sheetz. Spatial-temporal reorganization of activated integrins.
Cell adhesion & migration.
2012 May; 6(3):280-4. doi:
10.4161/cam.20753. [PMID: 22863737] - Azza Al-Tawashi, Sung Yun Jung, Dou Liu, Bing Su, Jun Qin. Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity.
The Journal of biological chemistry.
2012 Apr; 287(18):14644-58. doi:
10.1074/jbc.m111.261875. [PMID: 22375002] - Cristina Has, Giuseppina Spartà, Dimitra Kiritsi, Lisa Weibel, Alexander Moeller, Virginia Vega-Warner, Aoife Waters, Yinghong He, Yair Anikster, Philipp Esser, Beate K Straub, Ingrid Hausser, Detlef Bockenhauer, Benjamin Dekel, Friedhelm Hildebrandt, Leena Bruckner-Tuderman, Guido F Laube. Integrin α3 mutations with kidney, lung, and skin disease.
The New England journal of medicine.
2012 Apr; 366(16):1508-14. doi:
10.1056/nejmoa1110813. [PMID: 22512483] - V Härmä, M Knuuttila, J Virtanen, T Mirtti, P Kohonen, P Kovanen, A Happonen, S Kaewphan, I Ahonen, O Kallioniemi, R Grafström, J Lötjönen, M Nees. Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models.
Oncogene.
2012 Apr; 31(16):2075-89. doi:
10.1038/onc.2011.396. [PMID: 21996742] - Eva Altrock, Christine A Muth, Gerd Klein, Joachim P Spatz, Cornelia Lee-Thedieck. The significance of integrin ligand nanopatterning on lipid raft clustering in hematopoietic stem cells.
Biomaterials.
2012 Apr; 33(11):3107-18. doi:
10.1016/j.biomaterials.2012.01.002. [PMID: 22269650] - Peter H O'Donnell, Samir D Undevia, Walter M Stadler, Theodore M Karrison, M Kelly Nicholas, Linda Janisch, Mark J Ratain. A phase I study of continuous infusion cilengitide in patients with solid tumors.
Investigational new drugs.
2012 Apr; 30(2):604-10. doi:
10.1007/s10637-010-9537-9. [PMID: 20839028] - Haiyan Qu, Tingting Wen, Monika Pesch, Monique Aumailley. Partial loss of epithelial phenotype in kindlin-1-deficient keratinocytes.
The American journal of pathology.
2012 Apr; 180(4):1581-92. doi:
10.1016/j.ajpath.2012.01.005. [PMID: 22326752] - B A Naaijkens, H W M Niessen, H-J Prins, P A J Krijnen, T J A Kokhuis, N de Jong, V W M van Hinsbergh, O Kamp, M N Helder, R J P Musters, A van Dijk, L J M Juffermans. Human platelet lysate as a fetal bovine serum substitute improves human adipose-derived stromal cell culture for future cardiac repair applications.
Cell and tissue research.
2012 Apr; 348(1):119-30. doi:
10.1007/s00441-012-1360-5. [PMID: 22395775] - Farbod Shojaei, Nathan Scott, Xiaolin Kang, Patrick B Lappin, Amanda A Fitzgerald, Shannon Karlicek, Brett H Simmons, Aidong Wu, Joseph H Lee, Simon Bergqvist, Eugenia Kraynov. Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer.
Journal of experimental & clinical cancer research : CR.
2012 Mar; 31(?):26. doi:
10.1186/1756-9966-31-26. [PMID: 22444159] - Ronit Mor-Cohen, Nurit Rosenberg, Yulia Einav, Ehud Zelzion, Meytal Landau, Wissam Mansour, Yulia Averbukh, Uri Seligsohn. Unique disulfide bonds in epidermal growth factor (EGF) domains of β3 affect structure and function of αIIbβ3 and αvβ3 integrins in different manner.
The Journal of biological chemistry.
2012 Mar; 287(12):8879-91. doi:
10.1074/jbc.m111.311043. [PMID: 22308022] - Joseph R Klim, Anthony J Fowler, Adam H Courtney, Paul J Wrighton, Rachael T C Sheridan, Margaret L Wong, Laura L Kiessling. Small-molecule-modified surfaces engage cells through the αvβ3 integrin.
ACS chemical biology.
2012 Mar; 7(3):518-25. doi:
10.1021/cb2004725. [PMID: 22201290] - Xiuwei H Yang, Rossen Mirchev, Xinyu Deng, Patrick Yacono, Helen L Yang, David E Golan, Martin E Hemler. CD151 restricts the α6 integrin diffusion mode.
Journal of cell science.
2012 Mar; 125(Pt 6):1478-87. doi:
10.1242/jcs.093963. [PMID: 22328509] - Mohamed Bouaouina, Benjamin T Goult, Clotilde Huet-Calderwood, Neil Bate, Nina N Brahme, Igor L Barsukov, David R Critchley, David A Calderwood. A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.
The Journal of biological chemistry.
2012 Mar; 287(10):6979-90. doi:
10.1074/jbc.m111.330845. [PMID: 22235127] - Michael P Weekes, Robin Antrobus, Suzanne Talbot, Simon Hör, Nikol Simecek, Duncan L Smith, Stuart Bloor, Felix Randow, Paul J Lehner. Proteomic plasma membrane profiling reveals an essential role for gp96 in the cell surface expression of LDLR family members, including the LDL receptor and LRP6.
Journal of proteome research.
2012 Mar; 11(3):1475-84. doi:
10.1021/pr201135e. [PMID: 22292497] - Uta Praekelt, Petra M Kopp, Kerstin Rehm, Stefan Linder, Neil Bate, Bipin Patel, Emmanuel Debrand, Ana Maria Manso, Robert S Ross, Franceso Conti, Ming-Zhi Zhang, Raymond C Harris, Roy Zent, David R Critchley, Susan J Monkley. New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.
European journal of cell biology.
2012 Mar; 91(3):180-91. doi:
10.1016/j.ejcb.2011.12.003. [PMID: 22306379] - R Javier-Reyna, V I Hernández-Ramírez, A González-Robles, I Galván-Mendoza, C Osorio-Trujillo, P Talamás-Rohana. Rab7 and actin cytoskeleton participate during mobilization of β1EHFNR in fibronectin-stimulated Entamoeba histolyticatrophozoites.
Microscopy research and technique.
2012 Mar; 75(3):285-93. doi:
10.1002/jemt.21056. [PMID: 21823201] - Janet E Digby, Fernando Martinez, Andrew Jefferson, Neil Ruparelia, Joshua Chai, Malgorzata Wamil, David R Greaves, Robin P Choudhury. Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms.
Arteriosclerosis, thrombosis, and vascular biology.
2012 Mar; 32(3):669-76. doi:
10.1161/atvbaha.111.241836. [PMID: 22267479] - Ismail Seckin, Mumin Uzunalan, Meltem Pekpak, Sibel Kokturk, Huseyin Sonmez, Zeynep Oztürk, Sibel Demirci, Elif Yaprak. Experimentally induced puromycine aminonucleoside nephrosis (PAN) in rats: evaluation of angiogenic protein platelet-derived endothelial cell growth factor (PD-ECGF) expression in glomeruli.
Journal of biomedical science.
2012 Feb; 19(?):24. doi:
10.1186/1423-0127-19-24. [PMID: 22335899] - N Schwab, J C Ulzheimer, R J Fox, T Schneider-Hohendorf, B C Kieseier, C M Monoranu, S M Staugaitis, W Welch, S Jilek, R A Du Pasquier, W Brück, K V Toyka, R M Ransohoff, H Wiendl. Fatal PML associated with efalizumab therapy: insights into integrin αLβ2 in JC virus control.
Neurology.
2012 Feb; 78(7):458-67; discussion 465. doi:
10.1212/wnl.0b013e3182478d4b. [PMID: 22302546] - Lei Wang, Ziyan Liu, Sivasai Balivada, Tej Shrestha, Stefan Bossmann, Marla Pyle, Loretta Pappan, Jishu Shi, Deryl Troyer. Interleukin-1β and transforming growth factor-β cooperate to induce neurosphere formation and increase tumorigenicity of adherent LN-229 glioma cells.
Stem cell research & therapy.
2012 Feb; 3(1):5. doi:
10.1186/scrt96. [PMID: 22330721] - Jae-Gyu Kim, Mi-Young Moon, Hee-Jun Kim, Yi Li, Dong-Keun Song, Jun-Sub Kim, Jae-Yong Lee, Jaebong Kim, Sung-Chan Kim, Jae-Bong Park. Ras-related GTPases Rap1 and RhoA collectively induce the phagocytosis of serum-opsonized zymosan particles in macrophages.
The Journal of biological chemistry.
2012 Feb; 287(7):5145-55. doi:
10.1074/jbc.m111.257634. [PMID: 22194606] - Christian M Probst, Rodrigo A Silva, Juliana P B Menezes, Tais F Almeida, Ivana N Gomes, Andréia C Dallabona, Luiz S Ozaki, Gregory A Buck, Daniela P Pavoni, Marco A Krieger, Patrícia S T Veras. A comparison of two distinct murine macrophage gene expression profiles in response to Leishmania amazonensis infection.
BMC microbiology.
2012 Feb; 12(?):22. doi:
10.1186/1471-2180-12-22. [PMID: 22321871] - Roxane M Fabre, George O Okeyo, Daniel R Talham. Supported lipid bilayers at skeletonized surfaces for the study of transmembrane proteins.
Langmuir : the ACS journal of surfaces and colloids.
2012 Feb; 28(5):2835-41. doi:
10.1021/la204485n. [PMID: 22229749] - Jiro Takito, Masanori Nakamura, Masaki Yoda, Takahide Tohmonda, Shinichi Uchikawa, Keisuke Horiuchi, Yoshiaki Toyama, Kazuhiro Chiba. The transient appearance of zipper-like actin superstructures during the fusion of osteoclasts.
Journal of cell science.
2012 Feb; 125(Pt 3):662-72. doi:
10.1242/jcs.090886. [PMID: 22349694] - Eui Hyung Lee, Yeon Hee Kim, Sinyoung Kim, Song-Ee Kim, Soo-Chan Kim. Usefulness of Enzyme-linked Immunosorbent Assay Using Recombinant BP180 and BP230 for Serodiagnosis and Monitoring Disease Activity of Bullous Pemphigoid.
Annals of dermatology.
2012 Feb; 24(1):45-55. doi:
10.5021/ad.2012.24.1.45. [PMID: 22363155] - Peter Schubert, Brankica Culibrk, Danielle Coupland, Ken Scammell, Maria Gyongyossy-Issa, Dana V Devine. Riboflavin and ultraviolet light treatment potentiates vasodilator-stimulated phosphoprotein Ser-239 phosphorylation in platelet concentrates during storage.
Transfusion.
2012 Feb; 52(2):397-408. doi:
10.1111/j.1537-2995.2011.03287.x. [PMID: 21827504] - Annegret Pelchen-Matthews, Sebastian Giese, Petra Mlčochová, Jane Turner, Mark Marsh. β2 integrin adhesion complexes maintain the integrity of HIV-1 assembly compartments in primary macrophages.
Traffic (Copenhagen, Denmark).
2012 Feb; 13(2):273-91. doi:
10.1111/j.1600-0854.2011.01306.x. [PMID: 22017400] - Dieter Rondas, Alejandra Tomas, Martinho Soto-Ribeiro, Bernhard Wehrle-Haller, Philippe A Halban. Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion.
The Journal of biological chemistry.
2012 Jan; 287(4):2423-36. doi:
10.1074/jbc.m111.279885. [PMID: 22139838] - Marta A Dozynkiewicz, Nigel B Jamieson, Iain Macpherson, Joan Grindlay, Peter V E van den Berghe, Anne von Thun, Jennifer P Morton, Charlie Gourley, Paul Timpson, Colin Nixon, Colin J McKay, Ross Carter, David Strachan, Kurt Anderson, Owen J Sansom, Patrick T Caswell, Jim C Norman. Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.
Developmental cell.
2012 Jan; 22(1):131-45. doi:
10.1016/j.devcel.2011.11.008. [PMID: 22197222] - Jianyong Huang, Xiaoling Peng, Chunyang Xiong, Jing Fang. Influence of substrate rigidity on primary nucleation of cell adhesion: a thermal fluctuation model.
Journal of colloid and interface science.
2012 Jan; 366(1):200-208. doi:
10.1016/j.jcis.2011.09.046. [PMID: 21999957] - Feng Ye, Chungho Kim, Mark H Ginsberg. Reconstruction of integrin activation.
Blood.
2012 Jan; 119(1):26-33. doi:
10.1182/blood-2011-04-292128. [PMID: 21921044] - Oliver Borst, Eva-Maria Schmidt, Patrick Münzer, Tanja Schönberger, Syeda T Towhid, Margitta Elvers, Christina Leibrock, Evi Schmid, Anja Eylenstein, Dietmar Kuhl, Andreas E May, Meinrad Gawaz, Florian Lang. The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes.
Blood.
2012 Jan; 119(1):251-61. doi:
10.1182/blood-2011-06-359976. [PMID: 22031864]