Exact Mass: 436.1522
Exact Mass Matches: 436.1522
Found 500 metabolites which its exact mass value is equals to given mass value 436.1522
,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Phlorizin
Phlorizin, also known as phlorizoside or phlorrhizen, belongs to the class of organic compounds known as flavonoid o-glycosides. Flavonoid O-glycosides are compounds containing a carbohydrate moiety which is O-glycosidically linked to the 2-phenylchromen-4-one flavonoid backbone. Phlorizin (also referred to as phloridzin; chemical name phloretin-2-‚âà√≠‚Äö√¢¬ß-D-glucopyranoside) is a glucoside of phloretin, a dihydrochalcone, a family of bicyclic flavonoids, which in turn is a subgroup in the diverse phenylpropanoid synthesis pathway in plants. In humans, phlorizin is involved in lactose degradation. Phlorizin is a bitter tasting compound. phlorizin is found, on average, in the highest concentration in a few different foods, such as mexican oregano, european plums, and apples and in a lower concentration in pomegranates and apricots. phlorizin has also been detected, but not quantified, in several different foods, such as epazotes, durians, chinese broccoli, sesames, and sweet potato. This could make phlorizin a potential biomarker for the consumption of these foods. It is of sweet taste and contains four molecules of water in the crystal. Phlorizin is found primarily in unripe Malus (apple), root bark of apple, trace amounts have been found in strawberry. It is poorly soluble in ether and cold water, but soluble in ethanol and hot water. Closely related species, such as pear (Pyrus communis), cherry, and other fruit trees in the Rosaceae do not contain phloridzin. Phlorizin was studied as a potential pharmaceutical treatment for type 2 diabetes, but has since been superseded by more selective and more promising synthetic analogs, such as empagliflozin, canagliflozin and dapagliflozin. Phlorizin is a competitive inhibitor of SGLT1 and SGLT2 because it competes with D-glucose for binding to the carrier; this reduces renal glucose transport, lowering the amount of glucose in the blood. Phlorizin is not an effective drug because when orally consumed, it is nearly entirely converted into phloretin by hydrolytic enzymes in the small intestine. Above 200 °C, it decomposes. Phlorizin is an aryl beta-D-glucoside that is phloretin attached to a beta-D-glucopyranosyl residue at position 2 via a glycosidic linkage. It has a role as a plant metabolite and an antioxidant. It is an aryl beta-D-glucoside, a member of dihydrochalcones and a monosaccharide derivative. It is functionally related to a phloretin. Phlorizin is a natural product found in Malus doumeri, Vaccinium macrocarpon, and other organisms with data available. See also: ... View More ... An aryl beta-D-glucoside that is phloretin attached to a beta-D-glucopyranosyl residue at position 2 via a glycosidic linkage. Isolated from apple leaves and bark Phlorizin (Floridzin) is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor. Phlorizin (Floridzin) is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.
Sanggenon A
Sanggenon A is a member of chromenes. sanggenon A is a natural product found in Morus cathayana, Morus mongolica, and Morus alba with data available.
E-3174
EXP3174 is a metabolite of losartan (previous name DuP753), which is a non-peptide angiotensin II receptor antagonist. EXP3174, a metabolite of losartan (MK 954, DuP 753) is more potent than losartan in blocking the angiotensin II-induced responses in vascular smooth muscle cells. (PMID: 8385175) D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4].
Artonin J
Artonin J is found in fruits. Artonin J is a constituent of the root bark of Artocarpus heterophyllus (jackfruit). Constituent of the root bark of Artocarpus heterophyllus (jackfruit). Artonin J is found in jackfruit and fruits.
Artonin E
Artonin E is found in breadfruit. Artonin E is a constituent of Artocarpus communis (breadfruit). Constituent of Artocarpus communis (breadfruit). Artonin E is found in breadfruit and fruits.
Albanin B
Albanin B is found in fruits. Albanin B is isolated from Morus alba (white mulberry) infected with Fusarium solani. Isolated from Morus alba (white mulberry) infected with Fusarium solani. Albanin B is found in fruits.
Delprostenato
METESIND
C471 - Enzyme Inhibitor > C2021 - Thymidylate Synthase Inhibitor
Broussonol B
Kraussianone 7
3,8-Bis(3-methoxy-4-hydroxyphenyl)-3,3a,8,8a-tetrahydro-1H-indeno[1,2-c]furan-5,7-diol
Sanggenon M
Epiafzelechin 3-O-beta-D-allopyranoside
Erysenegalensein L
Afzelechin 4-O-beta-D-glucopyranosdie
Petalopurpurenol
2-(1-Hydroxy-1-methylethyl)-3-hydroxy-2,3-dihydrofuranoalpinumisoflavone
Broussonol A
Dihydrostilbene base + 3O, 1carboxy, O-Hex
Annotation level-3
1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4-hydroxyphenyl-4-O-beta-D-glucopyranoside)-1-propanone
3-O-beta-D-glucopyranosyl-1,3,4-trihydroxy-5-methoxy-alpha-phenylstyrene
1-(2,4-dihydroxyphenyl-4-O-beta-D-glucopyranoside)-3-hydroxy-3-(4-hydroxyphenyl)-1-propanone
4-O-beta-D-glucopyranosylbenzyl vanilloate|amburoside B
7a,10a-dihydro-5-hydroxy-8,8-dimethyl-6-(2-methyl-1-oxobutyl)-4-phenyl-2H,8H-benzo[1,2]dioxolano[4,5:4,5]furo[2,3:5,6]benzo[1,2-b]pyran-2-one|mammea A/AB dioxalanocyclo E|Mammea A/AB dioxalanocyclo F
1-keto-3,10-epoxy-8beta-O-methacryloyl-4,15-dihydroxy-5-acetoxy-2,11-germacradiene, 6alpha,12-olide
3-(3,4-Dihydroxyphenyl)-5-hydroxy-6-(2-hydroxy-3-methyl-3-butenyl)-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b]dipyran-4-one
3,4-dihydro-10-hydroxy-7-methoxy-3-(R)-methyl-1H-3,4-dihydronaphtho-<2,3c>-pyran-1-one-9-O-beta-D-glucopyranoside|3,4-dihydro-10-hydroxy-7-methoxy-3-(R)-methyl-1H-3,4-dihydronaphtho-[2,3c]-pyran-1-one-9-O-beta-D-glucopyranoside
2,4 dihydroxyphenyl-[6-O-(3-hydroxy,3-phenyl propanoyl)]-O-beta-D-allopyranoside
3,4,4,5,5-Pentamethoxy-(2,3-oxydibenzoic acid dimethyl) ester
(2R*,6aS,11bR)-6a,11b-dihydro-5,6a,9-trihydroxy-2-(1-methylethenyl)-11b-(3-methyl-2-buten-1-yl)-1H,2H,6H-benzofuro[3,2-b]pyrano[2,3-g][1]-benzofuro-6-one|(2S*,6aS,11bR)-6a,11b-dihydro-5,6a,9-trihydroxy-2-(1-methylethenyl)-11b-(3-methyl-2-buten-1-yl)-1H,2H,6H-benzofuro[3,2-b]pyrano[2,3-g][1]-benzofuro-6-one|nigrasin E|nigrasin F
7-acetoxy-8-[3-acetoxy-2,2-dimethyltetrahydro-4-furanyl]flavone|terpurinflavone
(2R,3S)-2-(4-hydroxy-3,5-dimethoxyphenyl)-2,3,5,6-tetrahydrophenanthro[2,1-b]pyran-3,8,11-triol|chrysotoxol B
2-[3-(3,4-dihydroxyphenyl)propanoyl]-3,5-dihydroxyphenyl alpha-L-rhamnopyranoside|3-hydroxyphloretin 2-alpha-O-L-rhamnopyranoside|glycyphyllin B
2-(5,8-dihydroxy-2,2-dimethyl-chroman-6-yl)-5-hydroxy-8,8-dimethyl-8H-pyrano[3,2-g]chromen-4-one|Chromanoartobilochromene b
2,6-dimethoxy-4-hydroxyphenyl 3-hydroxyphenyl ketone 3-O-beta-glucopyranoside|triptephenoside
Phlorizin
Origin: Plant; Formula(Parent): C21H24O10; Bottle Name:Phloridzin; PRIME Parent Name:Phloretin-2-O-glucoside; PRIME in-house No.:S0307, Glycosides relative retention time with respect to 9-anthracene Carboxylic Acid is 0.718 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.713 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.714 Acquisition and generation of the data is financially supported by the Max-Planck-Society IPB_RECORD: 2021; CONFIDENCE confident structure Phlorizin (Floridzin) is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor. Phlorizin (Floridzin) is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.
EXP 3174
A biphenylyltetrazole that is losartan with the hydroxymethyl group at position 5 on the imidazole ring replaced with a carboxylic acid. D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4].
3,7,21-trihydroxy-17,17-dimethyl-14-(3-methylbut-2-en-1-yl)-10,12,16-trioxapentacyclo[11.8.0.0³,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(13),4(9),5,7,14,18,20-heptaen-2-one
3,7,21-trihydroxy-17,17-dimethyl-14-(3-methylbut-2-en-1-yl)-10,12,16-trioxapentacyclo[11.8.0.0³,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(13),4(9),5,7,14,18,20-heptaen-2-one_35.3\\%
3,7,21-trihydroxy-17,17-dimethyl-14-(3-methylbut-2-en-1-yl)-10,12,16-trioxapentacyclo[11.8.0.0³,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(13),4(9),5,7,14,18,20-heptaen-2-one_major
3,7,21-trihydroxy-17,17-dimethyl-14-(3-methylbut-2-en-1-yl)-10,12,16-trioxapentacyclo[11.8.0.0³,¹¹.0?,?.0¹?,²?]henicosa-1(13),4(9),5,7,14,18,20-heptaen-2-one
Ala Asp Met Thr
Ala Asp Thr Met
Ala Glu Met Ser
Ala Glu Ser Met
Ala Met Asp Thr
Ala Met Glu Ser
Ala Met Ser Glu
Ala Met Thr Asp
Ala Ser Glu Met
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Ala Thr Asp Met
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Cys Asp Ile Ser
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Cys Asp Thr Val
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Cys Glu Ser Val
Cys Glu Val Ser
Cys Ile Asp Ser
Cys Ile Ser Asp
Cys Leu Asp Ser
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Cys Met Pro Ser
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Cys Asn Asn Ser
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Asp Ile Cys Ser
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Glu Ala Met Ser
Glu Ala Ser Met
Glu Cys Ser Val
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Glu Gly Met Thr
Glu Gly Thr Met
Glu Met Ala Ser
Glu Met Gly Thr
Glu Met Ser Ala
Glu Met Thr Gly
Glu Ser Ala Met
Glu Ser Cys Val
Glu Ser Asp Ser
Glu Ser Met Ala
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Glu Ser Val Cys
Glu Thr Gly Met
Glu Thr Met Gly
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Gly Glu Met Thr
Gly Glu Thr Met
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Gly Thr Glu Met
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Ile Cys Asp Ser
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Leu Cys Asp Ser
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Met Ala Asp Thr
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Met Thr Ala Asp
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Met Thr Glu Gly
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Asn Cys Asn Ser
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Pro Cys Met Ser
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Ser Ala Glu Met
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Ser Cys Asp Ile
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Thr Glu Gly Met
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Thr Met Gly Glu
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(2R,4S)-1-(((9H-FLUOREN-9-YL)METHOXY)CARBONYL)-4-(((ALLYLOXY)CARBONYL)AMINO)PYRROLIDINE-2-CARBOXYLIC ACID
2H-Tetrazolium,2,5-diphenyl-3-[4-(2-phenylethenyl)phenyl]-, chloride (1:1)
4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester
2-(((3AR,4R,6R,6AR)-6-(6-AMINO-9H-PURIN-9-YL)-2,2-DIMETHYLTETRAHYDROFURO[3,4-D][1,3]DIOXOL-4-YL)METHYL)ISOINDOLINE-1,3-DIONE
[4-(2,4-difluorophenyl)-2-(4-methylpiperazine-1-carbonyl)phenyl] benzoate
1-[2-[[4-[(2-cyano-4-nitrophenyl)azo]phenyl]ethylamino]ethyl]pyridinium chloride
Benzyl 3,4,6-tri-O-acetyl-N-acetyl-alpha-D-galactosaminide
4-[(ALLYLOXY)CARBONYL]PIPERAZINE-2-CARBOXYLIC ACID, N1-FMOC PROTECTED 974-ALLYL 1-(9-H-FLUOREN-9-YLMETHYL) HYDROGEN PIPERAZINE-1,2,4-TRICARBOXYLATE
methyl (2E,5E)-7-[2-[(E)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-3,5-dihydroxycyclopentyl]hepta-2,5-dienoate
nigrasin E
An extended flavonoid that is 1,2,6a,11b-tetrahydro-6H-[1]benzofuro[3,2-b]furo[2,3-h]chromene substituted by hydroxy groups at positions 5, 6a and 9, a prenyl group at position 11b, a prop-1-en-2-yl group at position 2 and an oxo group at position 6. It has been isolated from the twigs of Morus nigra.
nigrasin F
An extended flavonoid that is the 2S*-diastereomer of nigrasin E. It has been isolated from the twigs of Morus nigra.
6-(3-cyclopentyloxy-4-methoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
3-Benzoylamino-1-[2-(4-benzoylamino-phenyl)-2-oxo-ethyl]-pyridinium
(5-Furan-2-yl-2,2-dimethyl-1,4-dihydro-2H-3-oxa-7-thia-6,9,11-triaza-benzo[c]fluoren-8-yl)-(tetrahydro-furan-2-ylmethyl)-amine
1-(3,5-Dimethylphenyl)-5-[[4-(4-morpholinyl)anilino]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
N-(4-chlorophenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide
1-[2-(5-fluoro-2-methyl-1H-indol-3-yl)ethyl]-3-(4-fluorophenyl)-1-(pyridin-4-ylmethyl)thiourea
1-[1-(4-Methoxyphenyl)-2,5-dimethyl-3-pyrrolyl]-2-[[4-methyl-5-(2-methyl-3-furanyl)-1,2,4-triazol-3-yl]thio]ethanone
3-[4-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]-3-oxo-[1,2,4]triazino[2,3-a]benzimidazol-2-yl]propanoic acid
N-[(3-methoxyphenyl)methyl]-1-[(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)sulfonyl]-3-piperidinecarboxamide
N-[5-(diethylsulfamoyl)-2-methoxyphenyl]-2-[(2,5-dimethylphenyl)thio]acetamide
6-Amino-5,7,7-tricyano-8-pyridin-4-yl-1,3,8,8a-tetrahydroisoquinoline-2-carboxylic acid (phenylmethyl) ester
4-[[2-(1,10b-Dihydropyrazolo[1,5-c]quinazolin-5-ylthio)-1-oxoethyl]amino]benzoic acid butyl ester
1-[2-(5-fluoro-2-methyl-1H-indol-3-yl)ethyl]-3-(3-fluorophenyl)-1-(3-pyridinylmethyl)thiourea
1-[2-(5-fluoro-2-methyl-1H-indol-3-yl)ethyl]-3-(4-fluorophenyl)-1-(3-pyridinylmethyl)thiourea
EVT-401
EVT-401 (P2X7 receptor antagonist-1) is a purinergic P2X7 receptor antagonist. EVT-401 has efficacy of combating?neuroinflammation[1].
VU0155094
VU0155094 is a positive allosteric modulator with differential activity at the various group III mGluRs[1].