Norwogonin (BioDeep_00000270596)

 

Secondary id: BioDeep_00000002772

PANOMIX_OTCML-2023


代谢物信息卡片


4H-1-Benzopyran-4-one, 2-phenyl-5,7,8-trihydroxy- (9CI)

化学式: C15H10O5 (270.052821)
中文名称: 去甲汉黄芩素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 12.5%

分子结构信息

SMILES: C1(O)=C(O)C2OC(C3C=CC=CC=3)=CC(=O)C=2C(O)=C1
InChI: InChI=1S/C15H10O5/c16-9-6-11(18)14(19)15-13(9)10(17)7-12(20-15)8-4-2-1-3-5-8/h1-7,16,18-19H

描述信息

Norwogonin is a trihydroxyflavone with the hydroxy groups at positions C-5, -7 and -8. It has a role as an antioxidant and a metabolite.
Norwogonin is a natural product found in Scutellaria discolor, Scutellaria strigillosa, and other organisms with data available.
A trihydroxyflavone with the hydroxy groups at positions C-5, -7 and -8.
Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (EV71) with an IC50 of 31.83 μg/ml[1]
Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (EV71) with an IC50 of 31.83 μg/ml[1]

同义名列表

28 个代谢物同义名

4H-1-Benzopyran-4-one, 2-phenyl-5,7,8-trihydroxy-; 2-Phenyl-5,7,8-trihydroxy-4H-1-benzopyran-4-one; 5,7,8-TRIHYDROXY-2-PHENYL-4H-1-BENZOPYRAN-4-ONE; 5,7,8-Trihydroxy-2-phenyl-4H-chromen-4-one; 4-DIMETHYLAMINO-4-ETHYLSTILBAZOLIUMIODIDE; 5,7,8-trihydroxy-2-phenyl-chromen-4-one; 5,7,8-trihydroxy-2-phenylchromen-4-one; FLAVONE, 5,7,8-TRIHYDROXY-; TRIHYDROXYFLAVONE, 5,7,8-; 7,8,4-trihydroxyflavone; 5,7,8-Trihydroxyflavone; 5,7,8-hydroxyflavone; UNII-70U0WT21IB; nor-wogonin; Norwogonin; 70U0WT21IB; isowogonin; 4H-1-Benzopyran-4-one, 2-phenyl-5,7,8-trihydroxy- (9CI); 5,7,8-trihydroxy-2-phenyl-4-chromenone; 5,7,8-trihydroxy-2-phenyl-chromone; AIDS-016591; BRN 0272168; AIDS016591; NSC 128304; NSC128304; 4443-09-8; ST5309217; C10113



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhang Wang, Qinqin Zhang, Ling Zhou, Gao Liu, Quanfeng Wu, Changwang Chen. Norwogonin flavone suppresses the growth of human colon cancer cells via mitochondrial mediated apoptosis, autophagy induction and triggering G2/M phase cell cycle arrest. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2020 May; 25(3):1449-1454. doi: . [PMID: 32862589]
  • Yelin Kang, Bong-Gyu Kim, Sunghoon Kim, Youngshim Lee, Youngdae Yoon. Inhibitory potential of flavonoids on PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 pleckstrin homology domain. Bioorganic & medicinal chemistry letters. 2017 02; 27(3):420-426. doi: 10.1016/j.bmcl.2016.12.051. [PMID: 28049590]
  • Bo-Eun Kwon, Jae-Hyoung Song, Hyuk-Hwan Song, Ju Won Kang, Sam Noh Hwang, Ki-Jong Rhee, Aeri Shim, Eun-Hye Hong, Yeon-Jeong Kim, Sang-Min Jeon, Sun-Young Chang, Dong-Eun Kim, Sungchan Cho, Hyun-Jeong Ko. Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice. PloS one. 2016; 11(5):e0155784. doi: 10.1371/journal.pone.0155784. [PMID: 27195463]
  • Yoko Miyasaki, John D Rabenstein, Joshua Rhea, Marie-Laure Crouch, Ulla M Mocek, Patricia Emmett Kittell, Margie A Morgan, Wesley Stephen Nichols, M M Van Benschoten, William David Hardy, George Y Liu. Isolation and characterization of antimicrobial compounds in plant extracts against multidrug-resistant Acinetobacter baumannii. PloS one. 2013; 8(4):e61594. doi: 10.1371/journal.pone.0061594. [PMID: 23630600]
  • Guan-Cheng Huang, Jyh-Ming Chow, Shing-Chuan Shen, Liang-Yo Yang, Cheng-Wei Lin, Yen-Chou Chen. Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages. International immunopharmacology. 2007 Aug; 7(8):1054-63. doi: 10.1016/j.intimp.2007.04.001. [PMID: 17570322]
  • Zai-Qun Liu, Xu-Yang Luo, Yun-Xiu Sun, Wei Wu, Chun-Ming Liu, Zhi-Qiang Liu, Shu-Ying Liu. The antioxidative effect of icariin in human erythrocytes against free-radical-induced haemolysis. The Journal of pharmacy and pharmacology. 2004 Dec; 56(12):1557-62. doi: 10.1211/0022357044869. [PMID: 15563763]
  • Myung Sun Lee, Won Keun Oh, Bo Yeon Kim, Soon Cheol Ahn, Dae Ook Kang, Cheon Bae Sohn, Hiroyuki Osada, Jong Seog Ahn. Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships. Planta medica. 2002 Dec; 68(12):1063-5. doi: 10.1055/s-2002-36351. [PMID: 12494330]