Isoorientin 7-O-(6'-O-(E)-feruloyl)glucoside (BioDeep_00000000208)

Main id: BioDeep_00000017265

Secondary id: BioDeep_00000018599, BioDeep_00000270293

natural product human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-4H-chromen-4-one

化学式: C21H20O11 (448.1006)
中文名称: 异荭草素
谱图信息: 最多检出来源 Viridiplantae(plant) 17.5%

分子结构信息

SMILES: c1(c(c(c2c(c1)oc(cc2=O)c1cc(c(cc1)O)O)O)[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O
InChI: InChI=1/C21H20O11/c22-6-14-17(27)19(29)20(30)21(32-14)16-11(26)5-13-15(18(16)28)10(25)4-12(31-13)7-1-2-8(23)9(24)3-7/h1-5,14,17,19-24,26-30H,6H2/t14-,17-,19+,20-,21+/m1/s1

描述信息

Isoorientin 7-o-(6-o-(e)-feruloyl)glucoside, also known as homoorientin or luteolin-6-C-beta-D-glucoside, is a member of the class of compounds known as flavonoid c-glycosides. Flavonoid c-glycosides are compounds containing a carbohydrate moiety which is C-glycosidically linked to the 2-phenylchromen-4-one flavonoid backbone. Isoorientin 7-o-(6-o-(e)-feruloyl)glucoside is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Isoorientin 7-o-(6-o-(e)-feruloyl)glucoside can be synthesized from luteolin. Isoorientin 7-o-(6-o-(e)-feruloyl)glucoside is also a parent compound for other transformation products, including but not limited to, isoorientin 7-O-glucoside, 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]isoorientin, and 7-O-(6-sinapoylglucosyl)isoorientin. Isoorientin 7-o-(6-o-(e)-feruloyl)glucoside can be found in barley, which makes isoorientin 7-o-(6-o-(e)-feruloyl)glucoside a potential biomarker for the consumption of this food product.
Acquisition and generation of the data is financially supported in part by CREST/JST.
[Raw Data] CBA21_Isoorientin_neg_20eV_1-3_01_1409.txt
[Raw Data] CBA21_Isoorientin_pos_20eV_1-3_01_1382.txt
[Raw Data] CBA21_Isoorientin_pos_50eV_1-3_01_1385.txt
[Raw Data] CBA21_Isoorientin_neg_40eV_1-3_01_1411.txt
[Raw Data] CBA21_Isoorientin_neg_10eV_1-3_01_1365.txt
[Raw Data] CBA21_Isoorientin_neg_50eV_1-3_01_1412.txt
[Raw Data] CBA21_Isoorientin_pos_10eV_1-3_01_1354.txt
[Raw Data] CBA21_Isoorientin_pos_40eV_1-3_01_1384.txt
[Raw Data] CBA21_Isoorientin_pos_30eV_1-3_01_1383.txt
[Raw Data] CBA21_Isoorientin_neg_30eV_1-3_01_1410.txt
Isoorientin is a potent inhibitor of COX-2 with an IC50 value of 39 μM.
Isoorientin is a potent inhibitor of COX-2 with an IC50 value of 39 μM.

同义名列表

17 个代谢物同义名

2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-4H-chromen-4-one; 2-(3,4-Dihydroxyphenyl)-6-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one; 2-(3,4-Dihydroxyphenyl)-6-β-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one; 2-(3,4-Dihydroxyphenyl)-6-b-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one; Isoorientin 7-O-(6-O-(E)-feruloyl)glucoside; Luteolin 6-C-beta-D-glucopyranoside; Luteolin-6-C-beta-D-glucoside; Luteolin-6-C-β-D-glucoside; Luteolin-6-C-b-D-glucoside; 6-C-Galactosylluteolin; luteolin-6-C-glucoside; Lespecapitioside; 6-Glc-luteolin; iso-orientin; Homoorientin; Isoorientin; Isoorientin



数据库引用编号

46 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

681 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AIMP2, BCL2, CASP3, CAT, MAPK8, NFE2L2, NQO1, PIK3CA, PRKAA2, PTGS2, STAT3, XDH
Peripheral membrane protein 2 ACHE, PTGS2
Endoplasmic reticulum membrane 3 BCL2, HMOX1, PTGS2
Nucleus 11 ACHE, AIMP2, BCL2, CASP3, HMOX1, MAPK8, MPO, NFE2L2, NQO1, PRKAA2, STAT3
cytosol 13 AIMP2, BCL2, CASP3, CAT, GPT, HMOX1, MAPK8, NFE2L2, NQO1, PIK3CA, PRKAA2, STAT3, XDH
dendrite 2 NQO1, PRKAA2
centrosome 1 NFE2L2
nucleoplasm 7 CASP3, HMOX1, MAPK8, MPO, NFE2L2, PRKAA2, STAT3
RNA polymerase II transcription regulator complex 2 NFE2L2, STAT3
Cell membrane 2 ACHE, TNF
Cytoplasmic side 1 HMOX1
lamellipodium 1 PIK3CA
Synapse 3 ACHE, MAPK8, NQO1
cell surface 2 ACHE, TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 3 ACHE, NFE2L2, PRKAA2
Golgi membrane 1 INS
lysosomal membrane 1 GAA
neuromuscular junction 1 ACHE
neuronal cell body 4 CASP3, NQO1, PRKAA2, TNF
Cytoplasm, cytosol 3 AIMP2, NFE2L2, NQO1
Lysosome 2 GAA, MPO
plasma membrane 6 ACHE, GAA, NFE2L2, PIK3CA, STAT3, TNF
Membrane 8 ACHE, AIMP2, BCL2, CAT, GAA, HMOX1, NQO1, PRKAA2
axon 2 MAPK8, PRKAA2
caveola 1 PTGS2
extracellular exosome 4 CAT, GAA, GPT, MPO
Lysosome membrane 1 GAA
endoplasmic reticulum 3 BCL2, HMOX1, PTGS2
extracellular space 7 ACHE, HMOX1, IL6, INS, MPO, TNF, XDH
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 3 ACHE, HMOX1, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, CAT
protein-containing complex 3 BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 3 CAT, GAA, MPO
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Secreted 4 ACHE, GAA, IL6, INS
extracellular region 7 ACHE, CAT, GAA, IL6, INS, MPO, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
transcription regulator complex 1 STAT3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 CAT
Peroxisome 2 CAT, XDH
basement membrane 1 ACHE
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 1 MPO
nuclear speck 1 PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
chromatin 2 NFE2L2, STAT3
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
Lipid-anchor, GPI-anchor 1 ACHE
endosome lumen 1 INS
tertiary granule membrane 1 GAA
cytoplasmic stress granule 1 PRKAA2
side of membrane 1 ACHE
myelin sheath 1 BCL2
azurophil granule 1 MPO
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
azurophil granule membrane 1 GAA
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
phagocytic vesicle lumen 1 MPO
synaptic cleft 1 ACHE
protein-DNA complex 1 NFE2L2
ficolin-1-rich granule membrane 1 GAA
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
nucleotide-activated protein kinase complex 1 PRKAA2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[Isoform H]: Cell membrane 1 ACHE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Senling Feng, Yuting Li, Hanhui Huang, Hongliang Huang, Yingying Duan, Zhongwen Yuan, Wenting Zhu, Zhengrong Mei, Lianxiang Luo, Pengke Yan. Isoorientin reverses lung cancer drug resistance by promoting ferroptosis via the SIRT6/Nrf2/GPX4 signaling pathway. European journal of pharmacology. 2023 Jun; ?(?):175853. doi: 10.1016/j.ejphar.2023.175853. [PMID: 37329975]
  • Tiehan Cui, Yun Lan, Yuying Lu, Fei Yu, Suai Lin, Yizhe Fu, Jiaxuan Qiu, Guangliang Niu. Isoorientin ameliorates H2O2-induced apoptosis and oxidative stress in chondrocytes by regulating MAPK and PI3K/Akt pathways. Aging. 2023 Jun; 15(?):. doi: 10.18632/aging.204768. [PMID: 37277114]
  • Sezen Yılmaz Sarıaltın, Özlem Bahadır Acıkara. Assessment of Correlation Analysis, Phytochemical Profile, and Biological Activities of Endemic Scorzonera Species from Turkey. Chemistry & biodiversity. 2022 Oct; 19(10):e202200007. doi: 10.1002/cbdv.202200007. [PMID: 36031843]
  • Flávia Bittencourt Brasil, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Evandro Luiz Dall'Oglio, Marcos Roberto de Oliveira. A Pretreatment with Isoorientin Attenuates Redox Disruption, Mitochondrial Impairment, and Inflammation Caused by Chlorpyrifos in a Dopaminergic Cell Line: Involvement of the Nrf2/HO-1 Axis. Neurotoxicity research. 2022 Aug; 40(4):1043-1056. doi: 10.1007/s12640-022-00517-3. [PMID: 35583593]
  • Zhongbao Zhang, Xiaoqin Tan, Xiaorong Sun, Jianhua Wei, Qing X Li, Zhongyi Wu. Isoorientin Affects Markers of Alzheimer's Disease via Effects on the Oral and Gut Microbiota in APP/PS1 Mice. The Journal of nutrition. 2022 01; 152(1):140-152. doi: 10.1093/jn/nxab328. [PMID: 34636875]
  • Xiaorong Sun, Xiaofeng Xue, Xiaqing Wang, Chun Zhang, Dengyu Zheng, Wei Song, Jiuran Zhao, Jianhua Wei, Zhongyi Wu, Zhongbao Zhang. Natural variation of ZmCGT1 is responsible for isoorientin accumulation in maize silk. The Plant journal : for cell and molecular biology. 2022 01; 109(1):64-76. doi: 10.1111/tpj.15549. [PMID: 34695260]
  • Buyun Kim, Ki Yong Lee, Byoungduck Park. Isoorientin Inhibits Amyloid β25-35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26227056. [PMID: 34834150]
  • Wenliang Wang, Denghui Gao, Qiancheng Zheng, Xi Zhao, Risong Na, Xinsheng Wan, Qing X Li. Interactions of isoorientin and its Semi-synthetic analogs with human serum albumin. Bioorganic chemistry. 2021 11; 116(?):105319. doi: 10.1016/j.bioorg.2021.105319. [PMID: 34488124]
  • Bruno César Correa Salles, Krissia Caroline Leme, Marcelo Aparecido da Silva, Cláudia Quintino da Rocha, Marcelo M P Tangerina, Wagner Vilegas, Sônia A Figueiredo, Stella Maris da Silveira Duarte, Maria Rita Rodrigues, Fernanda Borges de Araújo Paula. Protective effect of flavonoids from Passiflora edulis Sims on diabetic complications in rats. The Journal of pharmacy and pharmacology. 2021 Sep; 73(10):1361-1368. doi: 10.1093/jpp/rgab046. [PMID: 33772554]
  • Sultana Razia, Hyunsung Park, Eunju Shin, Kyu-Suk Shim, Eunae Cho, Sun-Yeou Kim. Effects of Aloe vera Flower Extract and Its Active Constituent Isoorientin on Skin Moisturization via Regulating Involucrin Expression: In Vitro and Molecular Docking Studies. Molecules (Basel, Switzerland). 2021 04; 26(9):. doi: 10.3390/molecules26092626. [PMID: 33946287]
  • Javad Mottaghipisheh, Norbert Kúsz, Judit Hohmann, Yu-Chi Tsai, Dezső Csupor. Isolation of secondary metabolites from the Iranian medicinal plant Eremurus persicus. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2021 Jan; 76(1-2):43-47. doi: 10.1515/znc-2020-0059. [PMID: 32681789]
  • Monaj Kumar Sarkar, Vellingiri Vadivel, Mamilla R Charan Raja, Santanu Kar Mahapatra. Investigation of phytochemical constituents of anti-leukemic herbal drugs used by the traditional healers of Purulia, Birbhum and Bankura districts of West Bengal. Natural product research. 2020 Dec; 34(23):3388-3393. doi: 10.1080/14786419.2019.1566818. [PMID: 30764661]
  • Erminiana Damiani de Mendonça Pereira, Juliana da Silva, Patrícia da Silva Carvalho, Ivana Grivicich, Jaqueline Nascimento Picada, Ilton Batista Salgado Júnior, Gabriela Jouglard Vasques, Mário Augusto da Silva Pereira, Flavio Henrique Reginatto, Alexandre de Barros Falcão Ferraz. In vivo and in vitro toxicological evaluations of aqueous extract from Cecropia pachystachya leaves. Journal of toxicology and environmental health. Part A. 2020 10; 83(19-20):659-671. doi: 10.1080/15287394.2020.1811817. [PMID: 32865139]
  • Mariane B Chagas, Daniel O B Pontes, Allan V D Albino, Emanuel J Ferreira, Jovelina S F Alves, Anallicy S Paiva, Daniel L Pontes, Silvana M Z Langansser, Leandro S Ferreira. Bioinspired oxidation in cytochrome P450 of isomers orientin and isoorientin using Salen complexes. Rapid communications in mass spectrometry : RCM. 2020 Sep; 34 Suppl 3(?):e8757. doi: 10.1002/rcm.8757. [PMID: 32061191]
  • Khanyisani Ziqubu, Phiwayinkosi V Dludla, Elizabeth Joubert, Christo J F Muller, Johan Louw, Luca Tiano, Bongani B Nkambule, Abidemi P Kappo, Sithandiwe E Mazibuko-Mbeje. Isoorientin: A dietary flavone with the potential to ameliorate diverse metabolic complications. Pharmacological research. 2020 08; 158(?):104867. doi: 10.1016/j.phrs.2020.104867. [PMID: 32407953]
  • Xiao-Lin Qiu, Qing-Feng Zhang. Identification and quantification of main flavonoids in the leaves of Bambusa multiplex cv. Fernleaf. Natural product research. 2020 Jul; 34(14):2076-2079. doi: 10.1080/14786419.2019.1569013. [PMID: 30721085]
  • Khanyisani Ziqubu, Christo J F Muller, Phiwayinkosi V Dludla, Sinenhlanhla X H Mthembu, Nnini Obonye, Johan Louw, Abidemi P Kappo, Sonia Silvestri, Patrick Orlando, Luca Tiano, Sithandiwe E Mazibuko-Mbeje. Impact of Isoorientin on Metabolic Activity and Lipid Accumulation in Differentiated Adipocytes. Molecules (Basel, Switzerland). 2020 Apr; 25(8):. doi: 10.3390/molecules25081773. [PMID: 32294890]
  • Yuwei Sun, Zhuo Chen, Jingya Yang, Ishmael Mutanda, Shiyi Li, Qian Zhang, Ying Zhang, Yulian Zhang, Yong Wang. Pathway-specific enzymes from bamboo and crop leaves biosynthesize anti-nociceptive C-glycosylated flavones. Communications biology. 2020 03; 3(1):110. doi: 10.1038/s42003-020-0834-3. [PMID: 32144397]
  • Ícaro Putinhon Caruso, Wagner Vilegas, Leandro Cristante de Oliveira, Marinônio Lopes Cornélio. Fluorescence spectroscopic and dynamics simulation studies on isoorientin binding with human serum albumin. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Mar; 228(?):117738. doi: 10.1016/j.saa.2019.117738. [PMID: 31718973]
  • Shihao Chen, Tongwang Luo, Qi Yu, Wenxuan Dong, Huiyan Zhang, Hui Zou. Isoorientin plays an important role in alleviating Cadmium-induced DNA damage and G0/G1 cell cycle arrest. Ecotoxicology and environmental safety. 2020 Jan; 187(?):109851. doi: 10.1016/j.ecoenv.2019.109851. [PMID: 31670181]
  • Hsu-Kai Huang, Shin-Yi Lee, Shu-Fen Huang, Yu-San Lin, Shih-Chi Chao, Shu-Fu Huang, Shih-Chun Lee, Tzu-Hurng Cheng, Shih-Hurng Loh, Yi-Ting Tsai. Isoorientin Decreases Cell Migration via Decreasing Functional Activity and Molecular Expression of Proton-Linked Monocarboxylate Transporters in Human Lung Cancer Cells. The American journal of Chinese medicine. 2020; 48(1):201-222. doi: 10.1142/s0192415x20500111. [PMID: 31918564]
  • Quan Gao, Yanhong Shi, Min Liao, Jinjing Xiao, Xiuxia Li, Lijun Zhou, Chengwu Liu, Peng Liu, Haiqun Cao. Laboratory and field evaluation of the aphidicidal activity of moso bamboo (Phyllostachys pubescens) leaf extract and identification of the active components. Pest management science. 2019 Dec; 75(12):3167-3174. doi: 10.1002/ps.5434. [PMID: 30941856]
  • Aleksandra Maria Juszczak, Marijana Zovko-Končić, Michał Tomczyk. Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives. Biomolecules. 2019 11; 9(11):. doi: 10.3390/biom9110731. [PMID: 31726801]
  • Hongnan Zheng, Mingfeng Zhang, Heng Luo, Hui Li. Isoorientin alleviates UVB-induced skin injury by regulating mitochondrial ROS and cellular autophagy. Biochemical and biophysical research communications. 2019 07; 514(4):1133-1139. doi: 10.1016/j.bbrc.2019.04.195. [PMID: 31101341]
  • Michael McCullagh, Cintia Alessandra Matiucci Pereira, Janete Harumi Yariwake. Use of ion mobility mass spectrometry to enhance cumulative analytical specificity and separation to profile 6-C/8-C-glycosylflavone critical isomer pairs and known-unknowns in medicinal plants. Phytochemical analysis : PCA. 2019 Jul; 30(4):424-436. doi: 10.1002/pca.2825. [PMID: 30891865]
  • Qi-Yun Wu, Zack Chun-Fai Wong, Cheng Wang, Aster Hei-Yiu Fung, Emily Oi-Ying Wong, Gallant Kar-Lun Chan, Tina Ting-Xia Dong, Yicun Chen, Karl Wah-Keung Tsim. Isoorientin derived from Gentiana veitchiorum Hemsl. flowers inhibits melanogenesis by down-regulating MITF-induced tyrosinase expression. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Apr; 57(?):129-136. doi: 10.1016/j.phymed.2018.12.006. [PMID: 30668315]
  • Arif Malik, Uzma Jamil, Tariq Tahir Butt, Sulayman Waquar, Siew Hua Gan, Hassan Shafique, Tassadaq Hussain Jafar. In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model. Drug design, development and therapy. 2019; 13(?):1501-1513. doi: 10.2147/dddt.s176698. [PMID: 31123393]
  • Li Yuan, Xueyi Li, Shenyuan He, Chunxia Gao, Chengtao Wang, Yuyu Shao. Effects of Natural Flavonoid Isoorientin on Growth Performance and Gut Microbiota of Mice. Journal of agricultural and food chemistry. 2018 Sep; 66(37):9777-9784. doi: 10.1021/acs.jafc.8b03568. [PMID: 30160114]
  • Esen Sezen Karaoğlan, Abdulmecit Albayrak, Zerrin Kutlu, Yasin Bayır. Gastroprotective and antioxidant effects of Eremurus spectabilis Bieb. methanol extract and its isolated component isoorientin on indomethacin induced gastric ulcers in rats1. Acta cirurgica brasileira. 2018 Jul; 33(7):609-618. doi: 10.1590/s0102-865020180070000006. [PMID: 30110062]
  • Min-Ji Kim, Seung-Hwan Kwon, Choon-Gon Jang, Han-Joo Maeng. Determination of isoorientin levels in rat plasma after oral administration of Vaccinum bracteatum Thunb. methanol extract by high-performance liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC. 2018 Jun; 32(6):e4188. doi: 10.1002/bmc.4188. [PMID: 29334125]
  • Dehong Huang, Lei Jin, Zhengkang Li, Ji Wu, Ni Zhang, Dianrong Zhou, Xiaorong Ni, Tieying Hou. Isoorientin triggers apoptosis of hepatoblastoma by inducing DNA double-strand breaks and suppressing homologous recombination repair. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 May; 101(?):719-728. doi: 10.1016/j.biopha.2018.02.142. [PMID: 29524880]
  • Izabel Lucena Gadioli, Marcela de Sá Barreto da Cunha, Mariana Veras Oliveira de Carvalho, Ana Maria Costa, Lívia de Lacerda de Oliveira Pineli. A systematic review on phenolic compounds in Passiflora plants: Exploring biodiversity for food, nutrition, and popular medicine. Critical reviews in food science and nutrition. 2018 Mar; 58(5):785-807. doi: 10.1080/10408398.2016.1224805. [PMID: 27645583]
  • Marisa C Gaspar, Diogo A Fonseca, Manuel J Antunes, Christian Frigerio, Nelson G M Gomes, M Vieira, Armanda E Santos, Maria T Cruz, Maria D Cotrim, Maria G Campos. Polyphenolic characterisation and bioactivity of an Oxalis pes-caprae L. leaf extract. Natural product research. 2018 Mar; 32(6):732-738. doi: 10.1080/14786419.2017.1335728. [PMID: 28627294]
  • Yinnan Sun, Kui Yang, Qin Cao, Jinde Sun, Yu Xia, Yinhang Wang, Wei Li, Chunhui Ma, Shouxin Liu. Homogenate-assisted Vacuum-powered Bubble Extraction of Moso Bamboo Flavonoids for On-line Scavenging Free Radical Capacity Analysis. Molecules (Basel, Switzerland). 2017 Jul; 22(7):. doi: 10.3390/molecules22071156. [PMID: 28696360]
  • Kotha Anilkumar, Gorla V Reddy, Rajaram Azad, Nagendra Sastry Yarla, Gangappa Dharmapuri, Anand Srivastava, Mohammad A Kamal, Reddanna Pallu. Evaluation of Anti-Inflammatory Properties of Isoorientin Isolated from Tubers of Pueraria tuberosa. Oxidative medicine and cellular longevity. 2017; 2017(?):5498054. doi: 10.1155/2017/5498054. [PMID: 28243356]
  • Xing Lin, Jinbin Wei, Yongxin Chen, Ping He, Jun Lin, Shimei Tan, Jinlan Nie, Shengjuan Lu, Min He, Zhongpeng Lu, Quanfang Huang. Isoorientin from Gypsophila elegans induces apoptosis in liver cancer cells via mitochondrial-mediated pathway. Journal of ethnopharmacology. 2016 Jul; 187(?):187-94. doi: 10.1016/j.jep.2016.04.050. [PMID: 27130644]
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