Wogonin (BioDeep_00000002575)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-; Flavone, 5,7-dihydroxy-8-methoxy- (7CI,8CI); Wogonin (6CI); 5,7-Dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one; 5,7-Dihydroxy-8-methoxyflavone

化学式: C16H12O5 (284.0684702)
中文名称: 汉黄芩黄酮, 汉黄芩素, 汉黄芩素
谱图信息: 最多检出来源 Viridiplantae(plant) 0.75%

分子结构信息

SMILES: c1(cc(c2c(c1OC)oc(cc2=O)c1ccccc1)O)O
InChI: InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3

描述信息

Wogonin is a dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8. It has a role as a cyclooxygenase 2 inhibitor, an antineoplastic agent, an angiogenesis inhibitor and a plant metabolite. It is a dihydroxyflavone and a monomethoxyflavone. It is a conjugate acid of a wogonin(1-).
Wogonin is a natural product found in Scutellaria likiangensis, Scutellaria amoena, and other organisms with data available.
A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8.
Annotation level-1
Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects.
Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects.

同义名列表

31 个代谢物同义名

4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-; Flavone, 5,7-dihydroxy-8-methoxy- (7CI,8CI); Wogonin (6CI); 5,7-Dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one; 5,7-Dihydroxy-8-methoxyflavone; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-; 5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one(Wogonin); 5,7-dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one; 5,7-dihydroxy-8-methoxy-2-phenyl-4H-chromen-4-one; 5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one; 5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one; FLAVONE, 5,7-DIHYDROXY-8-METHOXY-; 5,7-dihydroxy-8-methoxyflavone; Norwogonin 8-methyl ether; Wogonin, S. baicalensis; UNII-POK93PO28W; Wogonin hydrate; WOGONIN [INCI]; NCI60_040649; Wogonin,(S); POK93PO28W; Wogonin; Vogonin; wagonin; 5,7-dihydroxy-8-methoxy-2-phenyl-4-chromenone; 5-18-04-00571 (Beilstein Handbook Reference); 5,7-dihydroxy-8-methoxy-2-phenyl-chromone; BRN 0287152; AIDS-001403; AIDS001403; NSC717845; ST077088; 632-85-9; 10-29-7; C10197



数据库引用编号

61 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

109 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(107)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

57 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shiyong Gao, Huixin Tan, Jian Gang. Inhibition of hepatocellular carcinoma cell proliferation through regulation of the Cell Cycle, AGE-RAGE, and Leptin signaling pathways by a compound formulation comprised of andrographolide, wogonin, and oroxylin A derived from Andrographis Paniculata(Burm.f.) Nees. Journal of ethnopharmacology. 2024 Jul; 329(?):118001. doi: 10.1016/j.jep.2024.118001. [PMID: 38467318]
  • Xixi Wang, Yanfei Wang, Jing Chen, Qinyao Wang, Zhongjian Liu, Yijie Yin, Tonghua Yang, Tao Shen, Yalian Sa. On the mechanism of wogonin against acute monocytic leukemia using network pharmacology and experimental validation. Scientific reports. 2024 05; 14(1):10114. doi: 10.1038/s41598-024-60859-0. [PMID: 38698063]
  • Jie Zhang, Cong Qi, He Li, Chenhuan Ding, Libo Wang, Hongjin Wu, Weiwei Dai, Chenglong Wang. Exploration of the effect and mechanism of Scutellaria barbata D. Don in the treatment of ovarian cancer based on network pharmacology and in vitro experimental verification. Medicine. 2023 Dec; 102(51):e36656. doi: 10.1097/md.0000000000036656. [PMID: 38134066]
  • Xin He, Juan Wang, Lei Sun, Wenqi Ma, Miao Li, Shanshan Yu, Qi Zhou, Jue Jiang. Wogonin attenuates inflammation and oxidative stress in lipopolysaccharide-induced mastitis by inhibiting Akt/NF-κB pathway and activating the Nrf2/HO-1 signaling. Cell stress & chaperones. 2023 Nov; ?(?):. doi: 10.1007/s12192-023-01391-4. [PMID: 37910344]
  • Ming-Yue Ma, Qian Wang, Shou-Mei Wang, Xiao-Jun Feng, Zhi-Hong Xian, Shu-Hui Zhang. Wogonin inhibits hepatoma cell proliferation by targeting miR-27b-5p/YWHAZ axis. Journal of biochemical and molecular toxicology. 2023 Aug; ?(?):e23508. doi: 10.1002/jbt.23508. [PMID: 37623816]
  • Zhenhua Ni, Honghong Ma, Xiaodong Li, Liwei Zou, Zongjun Liu, Xiongbiao Wang, Hong Ma, Ling Yang. Wogonin alleviates BaP-induced DNA damage and oxidative stress in human airway epithelial cells by dual inhibiting CYP1A1 activity and expression. Environmental toxicology. 2023 Jul; ?(?):. doi: 10.1002/tox.23907. [PMID: 37515497]
  • Hardeep Singh Tuli, Prangya Rath, Abhishek Chauhan, Gaurav Parashar, Nidarshana Chaturvedi Parashar, Hemant Joshi, Isha Rani, Seema Ramniwas, Diwakar Aggarwal, Manoj Kumar, Rashmi Rana. Wogonin, as a potent anticancer compound: From chemistry to cellular interactions. Experimental biology and medicine (Maywood, N.J.). 2023 Jun; ?(?):15353702231179961. doi: 10.1177/15353702231179961. [PMID: 37387217]
  • Anna Radajewska, Helena Moreira, Dorota Bęben, Oliwia Siwiela, Anna Szyjka, Katarzyna Gębczak, Paulina Nowak, Jakub Frąszczak, Fathi Emhemmed, Christian D Muller, Ewa Barg. Combination of Irinotecan and Melatonin with the Natural Compounds Wogonin and Celastrol for Colon Cancer Treatment. International journal of molecular sciences. 2023 May; 24(11):. doi: 10.3390/ijms24119544. [PMID: 37298495]
  • Xuemei Liu, Yan Yu, Yanqing Wu, Ai Luo, Mei Yang, Ting Li, Tingqian Li, Bing Mao, Xiaoting Chen, Juanjuan Fu, Hongli Jiang, Wei Liu. A systematic pharmacology-based in vivo study to reveal the effective mechanism of Yupingfeng in asthma treatment. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154783. doi: 10.1016/j.phymed.2023.154783. [PMID: 37004399]
  • Jitian Li, Weifeng Duan, Shuang Chai, Yage Luo, Yan Ma, Ning Yang, Man Liu, Wei He. Wogonin, a Bioactive Ingredient from Huangqi Guizhi Formula, Alleviates Discogenic Low Back Pain via Suppressing the Overexpressed NGF in Intervertebral Discs. Mediators of inflammation. 2023; 2023(?):4436587. doi: 10.1155/2023/4436587. [PMID: 36860203]
  • Yuening Sun, Wenjing Guo, Yongjian Guo, Zhangxing Lin, Dechao Wang, Qinglong Guo, Yuxin Zhou. Apoptosis induction in human prostate cancer cells related to the fatty acid metabolism by wogonin-mediated regulation of the AKT-SREBP1-FASN signaling network. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022 Nov; 169(?):113450. doi: 10.1016/j.fct.2022.113450. [PMID: 36208653]
  • Yasunari Yamada, Hodaka Saito, Masaya Araki, Yuhei Tsuchimoto, Shin-Ichi Muroi, Kyohei Suzuki, Kazufumi Toume, Jun-Dal Kim, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano, Yoshimi Nakagawa. Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4-FGF21 Signaling in Mouse Hepatocyte AML12 Cells. Nutrients. 2022 Sep; 14(19):. doi: 10.3390/nu14193920. [PMID: 36235573]
  • Caiyun Chen, Gaotian Li, Long Dai, Huijuan Zhao, Ning Li, Wei Mi, Shuying Yin, Shaoping Wang, Jiayu Zhang. Simultaneous separation of glycyrrhizic acid, baicalein and wogonin from Radix Glycyrrhizae and Radix Scutellariae using foam fractionation and in vitro activity evaluation. Journal of the science of food and agriculture. 2022 Sep; 102(12):5200-5209. doi: 10.1002/jsfa.11872. [PMID: 35289954]
  • Kishore Banik, Elina Khatoon, Choudhary Harsha, Varsha Rana, Dey Parama, Krishan Kumar Thakur, Anupam Bishayee, Ajaikumar B Kunnumakkara. Wogonin and its analogs for the prevention and treatment of cancer: A systematic review. Phytotherapy research : PTR. 2022 May; 36(5):1854-1883. doi: 10.1002/ptr.7386. [PMID: 35102626]
  • Fan Ping, Yanxia Wang, Xia Shen, Conge Tan, Lin Zhu, Wenwen Xing, Jun Xu. Virtual Screening and Molecular Docking to Study the Mechanism of Chinese Medicines in the Treatment of Coronavirus Infection. Medical science monitor : international medical journal of experimental and clinical research. 2022 Jan; 28(?):e934102. doi: 10.12659/msm.934102. [PMID: 35075100]
  • Yi Wu, Xinqiao Liu, Guiwei Li. Integrated bioinformatics and network pharmacology to identify the therapeutic target and molecular mechanisms of Huangqin decoction on ulcerative Colitis. Scientific reports. 2022 01; 12(1):159. doi: 10.1038/s41598-021-03980-8. [PMID: 34997010]
  • Cholil Yun, Shengfang Wang, Yuan Gao, Zhuowen Zhao, Na Miao, Yutong Shi, Ilbong Ri, Wenjie Wang, Huimei Wang. Optimization of ultrasound-assisted enzymatic pretreatment for enhanced extraction of baicalein and wogonin from Scutellaria baicalensis roots. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Jan; 1188(?):123077. doi: 10.1016/j.jchromb.2021.123077. [PMID: 34894479]
  • Xue-Qi Liu, Ling Jiang, Yuan-Yuan Li, Yue-Bo Huang, Xue-Ru Hu, Wei Zhu, Xian Wang, Yong-Gui Wu, Xiao-Ming Meng, Xiang-Ming Qi. Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease. Acta pharmacologica Sinica. 2022 Jan; 43(1):96-110. doi: 10.1038/s41401-021-00721-5. [PMID: 34253875]
  • Cheng Zhou, Xiaoling Yin. Wogonin Ameliorated Obesity-Induced Lipid Metabolism Disorders and Cardiac Injury via Suppressing Pyroptosis and Deactivating IL-17 Signaling Pathway. The American journal of Chinese medicine. 2022; 50(6):1553-1564. doi: 10.1142/s0192415x22500653. [PMID: 35770725]
  • Keyan Wu, Man Teng, Wei Zhou, Fanglin Lu, Yang Zhou, Jing Zeng, Jie Yang, Xinnong Liu, Yu Zhang, Yanbing Ding, Weigan Shen. Wogonin Induces Cell Cycle Arrest and Apoptosis of Hepatocellular Carcinoma Cells by Activating Hippo Signaling. Anti-cancer agents in medicinal chemistry. 2022; 22(8):1551-1560. doi: 10.2174/1871520621666210824105915. [PMID: 34431466]
  • Jinlin Ge, Huanhuan Yang, Yufeng Zeng, Yunjie Liu. Protective effects of wogonin on lipopolysaccharide-induced inflammation and apoptosis of lung epithelial cells and its possible mechanisms. Biomedical engineering online. 2021 Dec; 20(1):125. doi: 10.1186/s12938-021-00965-6. [PMID: 34906140]
  • Zhao Tianyu, Cui Xiaoli, Wang Yaru, Zhang Min, Yue Fengli, He Kan, Chen Li, Li Jing. New tale on LianHuaQingWen: IL6R/IL6/IL6ST complex is a potential target for COVID-19 treatment. Aging. 2021 11; 13(21):23913-23935. doi: 10.18632/aging.203666. [PMID: 34731090]
  • Mohammad A Alfhili, Ahmed M Basudan, Jawaher Alsughayyir. Antiproliferative Wnt inhibitor wogonin prevents eryptosis following ionophoric challenge, hyperosmotic shock, oxidative stress, and metabolic deprivation. Journal of food biochemistry. 2021 11; 45(11):e13977. doi: 10.1111/jfbc.13977. [PMID: 34664287]
  • Justyna Chanaj-Kaczmarek, Tomasz Osmałek, Emilia Szymańska, Katarzyna Winnicka, Tomasz M Karpiński, Magdalena Dyba, Marta Bekalarska-Dębek, Judyta Cielecka-Piontek. Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of Scutellariae baicalensis radix Extract and Chitosan for Periodontal Diseases Treatment. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111319. [PMID: 34768748]
  • Tomasz Tronina, Monika Mrozowska, Agnieszka Bartmańska, Jarosław Popłoński, Sandra Sordon, Ewa Huszcza. Simple and Rapid Method for Wogonin Preparation and Its Biotransformation. International journal of molecular sciences. 2021 Aug; 22(16):. doi: 10.3390/ijms22168973. [PMID: 34445678]
  • Su Liang, Zeyu Wang, Luyu Qi, Chao Tang, Yiming Zhang, Qun Luo, Yayun Wu, Jinghe Yuan, Yao Zhao, Yanyan Zhang, Xiaohong Fang, Shijun Wang, Fuyi Wang. Fluorescence live cell imaging revealed wogonin targets mitochondria. Talanta. 2021 Aug; 230(?):122328. doi: 10.1016/j.talanta.2021.122328. [PMID: 33934785]
  • Ji-Min Dai, Wei-Nan Guo, Yi-Zhou Tan, Kun-Wei Niu, Jia-Jia Zhang, Cheng-Li Liu, Xiang-Min Yang, Kai-Shan Tao, Zhi-Nan Chen, Jing-Yao Dai. Wogonin alleviates liver injury in sepsis through Nrf2-mediated NF-κB signalling suppression. Journal of cellular and molecular medicine. 2021 06; 25(12):5782-5798. doi: 10.1111/jcmm.16604. [PMID: 33982381]
  • Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee. Simultaneous determination of asarinin, β-eudesmol, and wogonin in rats using ultraperformance liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies following administration of standards and Gumiganghwal-tang. Biomedical chromatography : BMC. 2021 Apr; 35(4):e5021. doi: 10.1002/bmc.5021. [PMID: 33169364]
  • Yingjie Qing, Hui Li, Yunzi Zhao, Po Hu, Xiangyuan Wang, Xiaoxuan Yu, Mengyuan Zhu, Hongzheng Wang, Zhanyu Wang, Qinglong Guo, Hui Hui. One-Two Punch Therapy for the Treatment of T-Cell Malignancies Involving p53-Dependent Cellular Senescence. Oxidative medicine and cellular longevity. 2021; 2021(?):5529518. doi: 10.1155/2021/5529518. [PMID: 34603598]
  • Lei Lei, Jing Zhao, Xue-Qi Liu, Juan Chen, Xiang-Ming Qi, Ling-Ling Xia, Yong-Gui Wu. Wogonin Alleviates Kidney Tubular Epithelial Injury in Diabetic Nephropathy by Inhibiting PI3K/Akt/NF-κB Signaling Pathways. Drug design, development and therapy. 2021; 15(?):3131-3150. doi: 10.2147/dddt.s310882. [PMID: 34295152]
  • Rajesh Kumar, Seetha Harilal, Della G T Parambi, Siju E Narayanan, Md Sahab Uddin, Akash Marathakam, Jobin Jose, Githa E Mathew, Bijo Mathew. Fascinating Chemopreventive Story of Wogonin: A Chance to Hit on the Head in Cancer Treatment. Current pharmaceutical design. 2021; 27(4):467-478. doi: 10.2174/1385272824999200427083040. [PMID: 32338206]
  • Do Luong Huynh, Tran Hoang Ngau, Nguyen Hoai Nguyen, Gia-Buu Tran, Cuong Thach Nguyen. Potential therapeutic and pharmacological effects of Wogonin: an updated review. Molecular biology reports. 2020 Dec; 47(12):9779-9789. doi: 10.1007/s11033-020-05972-9. [PMID: 33165817]
  • Nobumitsu Hanioka, Takashi Isobe, Toshiko Tanaka-Kagawa, Susumu Ohkawara. Wogonin glucuronidation in liver and intestinal microsomes of humans, monkeys, dogs, rats, and mice. Xenobiotica; the fate of foreign compounds in biological systems. 2020 Aug; 50(8):906-912. doi: 10.1080/00498254.2020.1725180. [PMID: 32005083]
  • Caiyu Li, Xue Wang, Yajuan Bi, Heshui Yu, Jing Wei, Yi Zhang, Lifeng Han, Youcai Zhang. Potent Inhibitors of Organic Anion Transporters 1 and 3 From Natural Compounds and Their Protective Effect on Aristolochic Acid Nephropathy. Toxicological sciences : an official journal of the Society of Toxicology. 2020 06; 175(2):279-291. doi: 10.1093/toxsci/kfaa033. [PMID: 32159797]
  • Yuntai Huang, Lubo Guo, Renukaradhya Chitti, Nagaraja Sreeharsha, Anurag Mishra, Shiva K Gubbiyappa, Yogendra Singh. Wogonin ameliorate complete Freund's adjuvant induced rheumatoid arthritis via targeting NF-κB/MAPK signaling pathway. BioFactors (Oxford, England). 2020 Mar; 46(2):283-291. doi: 10.1002/biof.1585. [PMID: 31721330]
  • Liying Wang, Chenyu Li, Nagaraja Sreeharsha, Anurag Mishra, Vipin Shrotriya, Ajay Sharma. Neuroprotective effect of Wogonin on Rat's brain exposed to gamma irradiation. Journal of photochemistry and photobiology. B, Biology. 2020 Mar; 204(?):111775. doi: 10.1016/j.jphotobiol.2020.111775. [PMID: 31935591]
  • Zhengquan Huang, Xiaoqing Shi, Xiaochen Li, Li Zhang, Peng Wu, Jun Mao, Runlin Xing, Nongshan Zhang, Peimin Wang. Network Pharmacology Approach to Uncover the Mechanism Governing the Effect of Simiao Powder on Knee Osteoarthritis. BioMed research international. 2020; 2020(?):6971503. doi: 10.1155/2020/6971503. [PMID: 33376732]
  • Wan Bei, Li Jing, Nie Chen. Cardio protective role of wogonin loaded nanoparticle against isoproterenol induced myocardial infarction by moderating oxidative stress and inflammation. Colloids and surfaces. B, Biointerfaces. 2020 Jan; 185(?):110635. doi: 10.1016/j.colsurfb.2019.110635. [PMID: 31744760]
  • Bei Yin, Yi-Ming Bi, Guan-Jie Fan, Ya-Qing Xia. Molecular Mechanism of the Effect of Huanglian Jiedu Decoction on Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking. Journal of diabetes research. 2020; 2020(?):5273914. doi: 10.1155/2020/5273914. [PMID: 33134394]
  • Zhi-Chao Zheng, Wei Zhu, Lei Lei, Xue-Qi Liu, Yong-Gui Wu. Wogonin Ameliorates Renal Inflammation and Fibrosis by Inhibiting NF-κB and TGF-β1/Smad3 Signaling Pathways in Diabetic Nephropathy. Drug design, development and therapy. 2020; 14(?):4135-4148. doi: 10.2147/dddt.s274256. [PMID: 33116403]
  • Faiza Khushdil, Farzana Gul Jan, Gul Jan, Muhammad Hamayun, Amjad Iqbal, Anwar Hussain, Nusrat Bibi. Salt stress alleviation in Pennisetum glaucum through secondary metabolites modulation by Aspergillus terreus. Plant physiology and biochemistry : PPB. 2019 Nov; 144(?):127-134. doi: 10.1016/j.plaphy.2019.09.038. [PMID: 31563093]
  • Xiao-Sa Du, Hai-Di Li, Xiao-Juan Yang, Juan-Juan Li, Jie-Jie Xu, Yu Chen, Qing-Qing Xu, Lei Yang, Chang-Sheng He, Cheng Huang, Xiao-Ming Meng, Jun Li. Wogonin attenuates liver fibrosis via regulating hepatic stellate cell activation and apoptosis. International immunopharmacology. 2019 Oct; 75(?):105671. doi: 10.1016/j.intimp.2019.05.056. [PMID: 31377590]
  • Yi-Hong Wu, Li-Pang Chuang, Chao-Lan Yu, Shyi-Wu Wang, Hsin-Yung Chen, Ying-Ling Chang. Anticoagulant effect of wogonin against tissue factor expression. European journal of pharmacology. 2019 Sep; 859(?):172517. doi: 10.1016/j.ejphar.2019.172517. [PMID: 31265843]
  • Jubo Wang, Tinghan Li, Tengteng Zhao, Tizhi Wu, Chuang Liu, Hong Ding, Zhiyu Li, Jinlei Bian. Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity. European journal of medicinal chemistry. 2019 Sep; 178(?):782-801. doi: 10.1016/j.ejmech.2019.06.024. [PMID: 31238183]
  • D Jiao, Q Jiang, Y Liu, L Ji. Nephroprotective effect of wogonin against cadmium-induced nephrotoxicity via inhibition of oxidative stress-induced MAPK and NF-kB pathway in Sprague Dawley rats. Human & experimental toxicology. 2019 Sep; 38(9):1082-1091. doi: 10.1177/0960327119842635. [PMID: 31132876]
  • Khurshed Bozorov, Jiangyu Zhao, Haji A Aisa. 1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview. Bioorganic & medicinal chemistry. 2019 08; 27(16):3511-3531. doi: 10.1016/j.bmc.2019.07.005. [PMID: 31300317]
  • Han Xing, Chang Ren, Ying Kong, Qi Ni, Zeyu Wang, Di Zhao, Ning Li, Xijing Chen, Yang Lu. Determination of GL-V9, a derivative of wogonin, in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study after oral and pulmonary administration. Biomedical chromatography : BMC. 2019 Aug; 33(8):e4556. doi: 10.1002/bmc.4556. [PMID: 30990904]
  • Alaa M Badawy, Reem N El-Naga, Amany M Gad, Mariane G Tadros, Hala M Fawzy. Wogonin pre-treatment attenuates cisplatin-induced nephrotoxicity in rats: Impact on PPAR-γ, inflammation, apoptosis and Wnt/β-catenin pathway. Chemico-biological interactions. 2019 Aug; 308(?):137-146. doi: 10.1016/j.cbi.2019.05.029. [PMID: 31103702]
  • Qing Zhao, Jun Yang, Meng-Ying Cui, Jie Liu, Yumin Fang, Mengxiao Yan, Wenqing Qiu, Huiwen Shang, Zhicheng Xu, Reheman Yidiresi, Jing-Ke Weng, Tomáš Pluskal, Marielle Vigouroux, Burkhard Steuernagel, Yukun Wei, Lei Yang, Yonghong Hu, Xiao-Ya Chen, Cathie Martin. The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin Biosynthesis. Molecular plant. 2019 07; 12(7):935-950. doi: 10.1016/j.molp.2019.04.002. [PMID: 30999079]
  • Hao Tan, Xiang Li, Wei Han Yang, Yong Kang. A flavone, Wogonin from Scutellaria baicalensis inhibits the proliferation of human colorectal cancer cells by inducing of autophagy, apoptosis and G2/M cell cycle arrest via modulating the PI3K/AKT and STAT3 signalling pathways. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2019 May; 24(3):1143-1149. doi: . [PMID: 31424673]
  • Xia Da, Yayoi Nishiyama, Duerna Tie, Kyaw Zaw Hein, Osamu Yamamoto, Eishin Morita. Antifungal activity and mechanism of action of Ou-gon (Scutellaria root extract) components against pathogenic fungi. Scientific reports. 2019 02; 9(1):1683. doi: 10.1038/s41598-019-38916-w. [PMID: 30737463]
  • Yanqiu Gu, Xiaofei Chen, Rong Wang, Shaozhan Wang, Xiaoyu Wang, Leyi Zheng, Bin Zhang, Yifeng Chai, Zhenyu Zhu, Yongfang Yuan. Comparative two-dimensional HepG2 and L02/ cell membrane chromatography/ C18/ time-of-flight mass spectrometry for screening selective anti-hepatoma components from Scutellariae Radix. Journal of pharmaceutical and biomedical analysis. 2019 Feb; 164(?):550-556. doi: 10.1016/j.jpba.2018.10.028. [PMID: 30458388]
  • Dong-Zhu Tu, Hong-Ying Ma, Ya-Qiao Wang, Xiao-Hua Zhao, Wen-Zhi Guo, Guang-Bo Ge, Ling Yang. [Inhibitory effect of flavonoids from Scutellariae Radix on human cytochrome P450 1A]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Feb; 44(3):566-573. doi: 10.19540/j.cnki.cjcmm.20181128.005. [PMID: 30989924]
  • Shahzad Khan, Mohammad A Kamal. Can Wogonin be Used in Controlling Diabetic Cardiomyopathy?. Current pharmaceutical design. 2019; 25(19):2171-2177. doi: 10.2174/1381612825666190708173108. [PMID: 31298148]
  • Xue Jintao, Yang Quanwei, Li Chunyan, Jing Yun, Wang Shuangxi, Zhang Mingxiang, Li Peng. Rapid and Simultaneous Determination of Three Active Components in Raw and Processed Root Samples of Scutellaria baicalensis by Near-infrared Spectroscopy. Planta medica. 2019 Jan; 85(1):72-80. doi: 10.1055/a-0655-2211. [PMID: 30005428]
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