Vitexin 2-rhamnoside (BioDeep_00000003344)

Main id: BioDeep_00000230938

Secondary id: BioDeep_00000184982, BioDeep_00000230450, BioDeep_00000270797, BioDeep_00000398017, BioDeep_00000398653

natural product PANOMIX_OTCML-2023


代谢物信息卡片


Vitexin 2-O-beta-L-rhamnoside

化学式: C27H30O14 (578.163548)
中文名称: 牡荆素鼠李糖苷, 牡荆素-2-O-鼠李糖苷
谱图信息: 最多检出来源 Viridiplantae(plant) 7.37%

分子结构信息

SMILES: c1(cc(c2c(c1[C@H]1[C@@H]([C@H]([C@@H]([C@@H](O1)CO)O)O)O[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)C)O)O)O)oc(cc2=O)c1ccc(cc1)O)O)O
InChI: InChI=1/C27H30O14/c1-9-19(33)21(35)23(37)27(38-9)41-26-22(36)20(34)16(8-28)40-25(26)18-13(31)6-12(30)17-14(32)7-15(39-24(17)18)10-2-4-11(29)5-3-10/h2-7,9,16,19-23,25-31,33-37H,8H2,1H3/t9-,16+,19-,20+,21+,22-,23+,25-,26+,27-/m0/s1

描述信息

Acquisition and generation of the data is financially supported in part by CREST/JST.
Vitexin-2"-O-rhamnoside, a main flavonoid glycoside of the leaves of Cratagus pinnatifida Bge, contributes to the protection against H2O2-mediated oxidative stress damage and has potential to treat cardiovascular system diseases[1].
Vitexin-2"-O-rhamnoside, a main flavonoid glycoside of the leaves of Cratagus pinnatifida Bge, contributes to the protection against H2O2-mediated oxidative stress damage and has potential to treat cardiovascular system diseases[1].

同义名列表

7 个代谢物同义名

Vitexin 2-O-beta-L-rhamnoside; Vitexin-2"-O-rhamnoside; Vitexin 2-O-rhamnoside; Vitexin-2-O-rhamnoside; vitexin-2-O-rhamnoside; 2-O-Rhamnosylvitexin; Vitexin 2-rhamnoside



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

21 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xu Pang, Mei Wang, Shuang-Yan Wang, Jie Zhang, Ya-Peng Du, Ye Zhao, Xiao-Hui Zheng, Bai-Ping Ma. Phenolic compounds from the leaves of Crataegus pinnatifida Bge. var. major N.E.Br. And their lipid-lowering effects. Bioorganic & medicinal chemistry letters. 2021 09; 47(?):128211. doi: 10.1016/j.bmcl.2021.128211. [PMID: 34157392]
  • Jensen A Lund, Paula N Brown, Paul R Shipley. Quantification of North American and European Crataegus flavonoids by nuclear magnetic resonance spectrometry. Fitoterapia. 2020 Jun; 143(?):104537. doi: 10.1016/j.fitote.2020.104537. [PMID: 32145312]
  • Isabela M Lorizola, Cibele P B Furlan, Mariana Portovedo, Marciane Milanski, Patrícia B Botelho, Rosângela M N Bezerra, Beatriz R Sumere, Maurício A Rostagno, Caroline D Capitani. Beet Stalks and Leaves (Beta vulgaris L.) Protect Against High-Fat Diet-Induced Oxidative Damage in the Liver in Mice. Nutrients. 2018 Jul; 10(7):. doi: 10.3390/nu10070872. [PMID: 29976910]
  • Soo Yee Lee, Ahmed Mediani, Maulidiani Maulidiani, Alfi Khatib, Intan Safinar Ismail, Norhasnida Zawawi, Faridah Abas. Comparison of partial least squares and random forests for evaluating relationship between phenolics and bioactivities of Neptunia oleracea. Journal of the science of food and agriculture. 2018 Jan; 98(1):240-252. doi: 10.1002/jsfa.8462. [PMID: 28580581]
  • Paolino Ninfali, Elena Antonini, Alessandra Frati, Emanuele-Salvatore Scarpa. C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review. Phytotherapy research : PTR. 2017 Jun; 31(6):871-884. doi: 10.1002/ptr.5819. [PMID: 28464411]
  • Feng Han, Yupin Guo, Huiyan Gu, Fenglan Li, Baozhong Hu, Lei Yang. Application of alkyl polyglycoside surfactant in ultrasonic-assisted extraction followed by macroporous resin enrichment for the separation of vitexin-2″-O-rhamnoside and vitexin from Crataegus pinnatifida leaves. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Feb; 1012-1013(?):69-78. doi: 10.1016/j.jchromb.2016.01.017. [PMID: 26807707]
  • Yucong Gao, Yang Du, Zheming Ying, Aijing Leng, Wenjie Zhang, Yihan Meng, Cuiyu Li, Liang Xu, Xixiang Ying, Tingguo Kang. Hepatic, gastric and intestinal first-pass effects of vitexin-2''-O-rhamnoside in rats by ultra-high-performance liquid chromatography. Biomedical chromatography : BMC. 2016 Feb; 30(2):111-6. doi: 10.1002/bmc.3522. [PMID: 26031900]
  • Kexin Hou, Fengli Chen, Yuangang Zu, Lei Yang. Ionic liquids-lithium salts pretreatment followed by ultrasound-assisted extraction of vitexin-4″-O-glucoside, vitexin-2″-O-rhamnoside and vitexin from Phyllostachys edulis leaves. Journal of chromatography. A. 2016 Jan; 1431(?):17-26. doi: 10.1016/j.chroma.2015.12.067. [PMID: 26763300]
  • Hongjuan Li, Ying Liu, Haizhu Jin, Sujing Liu, Shengtao Fang, Chunhua Wang, Chuanhai Xia. Separation of vitexin-4″-O-glucoside and vitexin-2″-O-rhamnoside from hawthorn leaves extracts using macroporous resins. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Dec; 1007(?):23-9. doi: 10.1016/j.jchromb.2015.10.043. [PMID: 26562804]
  • Nadia Mustapha, Imèn Mokdad Bzéouich, Kamel Ghedira, Thierry Hennebelle, Leila Chekir-Ghedira. Compounds isolated from the aerial part of Crataegus azarolus inhibit growth of B16F10 melanoma cells and exert a potent inhibition of the melanin synthesis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2015 Feb; 69(?):139-44. doi: 10.1016/j.biopha.2014.11.010. [PMID: 25661350]
  • Wenjuan Wei, Xixiang Ying, Wenjie Zhang, Yinghui Chen, Aijing Leng, Chen Jiang, Jing Liu. Effects of vitexin-2"-O-rhamnoside and vitexin-4"-O-glucoside on growth and oxidative stress-induced cell apoptosis of human adipose-derived stem cells. The Journal of pharmacy and pharmacology. 2014 Jul; 66(7):988-97. doi: 10.1111/jphp.12225. [PMID: 24533889]
  • Abeer Moawad, Mona Hetta, Jordan K Zjawiony, Daneel Ferreira, Mohamed Hifnawy. Two new dihydroamentoflavone glycosides from Cycas revoluta. Natural product research. 2014; 28(1):41-7. doi: 10.1080/14786419.2013.832675. [PMID: 24404954]
  • Paolino Ninfali, Sabrina Dominici, Donato Angelino, Lorenzo Gennari, Costantina Buondelmonte, Luca Giorgi. An enzyme-linked immunosorbent assay for the measurement of plasma flavonoids in mice fed apigenin-C-glycoside. Journal of the science of food and agriculture. 2013 Sep; 93(12):3087-93. doi: 10.1002/jsfa.6143. [PMID: 23526334]
  • Yajun He, Juan Su, Qian Yang, Hui Liu, Weidong Zhang. [Simultaneous determination of chlorogenic acid and vitexin 2"-rhamnoside in Crataegi Fructus extracts by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Mar; 37(6):829-31. doi: . [PMID: 22715732]
  • Zhongzhe Cheng, Dong Wang, Wenjie Zhang, Yang Du, Yunjiao Wang, Yanjun Zhai, Xixiang Ying, Tingguo Kang. LC determination and pharmacokinetic study of the main phenolic components of Portulaca oleracea L. extract in rat plasma after oral administration. Natural product research. 2012; 26(23):2247-50. doi: 10.1080/14786419.2011.648193. [PMID: 22250700]
  • S Vargas, K Ndjoko Ioset, A-E Hay, J-R Ioset, S Wittlin, K Hostettmann. Screening medicinal plants for the detection of novel antimalarial products applying the inhibition of β-hematin formation. Journal of pharmaceutical and biomedical analysis. 2011 Dec; 56(5):880-6. doi: 10.1016/j.jpba.2011.06.026. [PMID: 21872416]
  • Wenjun Zhang, Ming Xu, Chaoqun Yu, Guofeng Zhang, Xing Tang. Simultaneous determination of vitexin-4''-O-glucoside, vitexin-2''-O-rhamnoside, rutin and vitexin from hawthorn leaves flavonoids in rat plasma by UPLC-ESI-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Jul; 878(21):1837-44. doi: 10.1016/j.jchromb.2010.05.023. [PMID: 20570577]
  • Emanuela Martino, Simona Collina, Daniela Rossi, Deborah Bazzoni, Raffaella Gaggeri, Francesco Bracco, Ornella Azzolina. Influence of the extraction mode on the yield of hyperoside, vitexin and vitexin-2''-O-rhamnoside from Crataegus monogyna Jacq. (hawthorn). Phytochemical analysis : PCA. 2008 Nov; 19(6):534-40. doi: 10.1002/pca.1081. [PMID: 18618435]
  • Lu Qu, Hang-Sheng Zheng, Nian-Ping Feng, Song-Ming Li. [Determination of vitexin-rhamnoside in Beagle dog plasma and preliminary pharmacokinetics of Yixintong sustained release tablets]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 May; 33(10):1168-70. doi: NULL. [PMID: 18720869]
  • Ying-ai Xu, Guorong Fan, Shen Gao, Zhanying Hong. Assessment of intestinal absorption of vitexin-2''-o-rhamnoside in hawthorn leaves flavonoids in rat using in situ and in vitro absorption models. Drug development and industrial pharmacy. 2008 Feb; 34(2):164-70. doi: 10.1080/03639040701484668. [PMID: 18302035]
  • Xixiang Ying, Shuo Gao, Wenliang Zhu, Yujin Bi, Feng Qin, Xiaoqin Li, Famei Li. High-performance liquid chromatographic determination and pharmacokinetic study of vitexin-2''-O-rhamnoside in rat plasma after intravenous administration. Journal of pharmaceutical and biomedical analysis. 2007 Jul; 44(3):802-6. doi: 10.1016/j.jpba.2007.03.015. [PMID: 17459645]
  • Guo Ma, Xue-Hua Jiang, Zhuo Chen, Jing Ren, Chen-Rui Li, Tai-Ming Liu. Simultaneous determination of vitexin-4''-O-glucoside and vitexin-2''-O-rhamnoside from Hawthorn leaves flavonoids in rat plasma by HPLC method and its application to pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2007 May; 44(1):243-9. doi: 10.1016/j.jpba.2007.01.033. [PMID: 17329058]
  • Shan Cheng, Feng Qiu, Jia Huang, Junqi He. Simultaneous determination of vitexin-2"-O-glucoside, vitexin-2"-O-rhamnoside, rutin, and hyperoside in the extract of hawthorn (Crataegus pinnatifida Bge.) leaves by RP-HPLC with ultraviolet photodiode array detection. Journal of separation science. 2007 Mar; 30(5):717-21. doi: 10.1002/jssc.200600353. [PMID: 17461112]
  • Rong-Hua Liu, Bo-Yang Yu. [Study on the chemical constituents of the leaves from Crataegus pinnatifida Bge. var. major N. E. Br]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2006 Nov; 29(11):1169-73. doi: . [PMID: 17228656]
  • Xiao-Xin Zhu, Lian-Da Li, Jian-Xun Liu, Zhi-Yun Liu, Xue-Ying Ma. [Effect of vitexia-rhamnoside (V-R) on vasomotor factors expression of endothelial cell]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 Apr; 31(7):566-9. doi: ". [PMID: 16780160]
  • Juan Su, Wei-dong Zhang, Yun Zhou, Jing Zhou, Zheng-bing Gu. [Determination of flavoniod-glycosides in Yixintong pills by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2004 Jun; 29(6):525-7. doi: . [PMID: 15706914]
  • J Sun, S Yang, G Li, Z Yang. [Investigation on method speliality in identifying Fructus Crataegi with vitexin rhamnoside]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2001 Dec; 24(12):859-61. doi: ". [PMID: 11917841]
  • M Schüssler, J Hölzl, A F Rump, U Fricke. Functional and antiischaemic effects of Monoacetyl-vitexinrhamnoside in different in vitro models. General pharmacology. 1995 Nov; 26(7):1565-70. doi: 10.1016/0306-3623(95)00051-8. [PMID: 8690247]
  • L D Li, Y G Li, F H Gao, Z Y Liu, J Zhang, L L Yu. Studies on hawthorn and its active principle. II. Effects on cultured rat heart cells deprived of oxygen and glucose. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 1984 Dec; 4(4):289-92. doi: ". [PMID: 6570503]
  • R Della Loggia, A Tubaro, C Redaelli. [Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them]. Rivista di neurologia. 1981 Sep; 51(5):297-310. doi: ". [PMID: 6118937]