Hydnocarpin (BioDeep_00000238983)

   

PANOMIX_OTCML-2023


代谢物信息卡片


4H-1-Benzopyran-4-one, 2-(2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl)-5,7-dihydroxy-, trans-

化学式: C25H20O9 (464.110727)
中文名称: 次大风子素消旋体, 次大风子素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 4.44%

分子结构信息

SMILES: COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=CC(=C3)C4=CC(=O)C5=C(C=C(C=C5O4)O)O)CO)O
InChI: InChI=1S/C25H20O9/c1-31-20-7-13(2-4-15(20)28)25-23(11-26)33-21-6-12(3-5-18(21)34-25)19-10-17(30)24-16(29)8-14(27)9-22(24)32-19/h2-10,23,25-29H,11H2,1H3

描述信息

Hydnocarpin is a natural product found in Lonicera japonica and Verbascum sinaiticum with data available.
(Rac)-Hydnocarpin is a flavonoid isolated from Hydnocarpus anthelminthica, and exhibits moderate cytotoxic on cancer cells[1].
(Rac)-Hydnocarpin is a flavonoid isolated from Hydnocarpus anthelminthica, and exhibits moderate cytotoxic on cancer cells[1].

同义名列表

6 个代谢物同义名

4H-1-Benzopyran-4-one, 2-(2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl)-5,7-dihydroxy-, trans-; 5,7-Dihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-4H-1-benzopyran-4-one; 5,7-dihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chromen-4-one; (Rac)-Hydnocarpin; Rac-Hydnocarpin; Hydnocarpin



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Laetitia M Youmbi, Yves S D Makong, Armelle T Mbaveng, Simplice B Tankeo, Ghislain W Fotso, Bruno L Ndjakou, Jean D Wansi, Veronique P Beng, Norbert Sewald, Bonaventure T Ngadjui, Thomas Efferth, Victor Kuete. Cytotoxicity of the methanol extracts and compounds of Brucea antidysenterica (Simaroubaceae) towards multifactorial drug-resistant human cancer cell lines. BMC complementary medicine and therapies. 2023 Feb; 23(1):48. doi: 10.1186/s12906-023-03877-1. [PMID: 36793009]
  • Siyue Lou, Huanwu Hong, Liwaliding Maihesuti, Hang Gao, Zhihui Zhu, Lili Xu, Shasha Tian, Guoyin Kai, Guozheng Huang, Huajun Zhao. Inhibitory effect of hydnocarpin D on T-cell acute lymphoblastic leukemia via induction of autophagy-dependent ferroptosis. Experimental biology and medicine (Maywood, N.J.). 2021 07; 246(13):1541-1553. doi: 10.1177/15353702211004870. [PMID: 33926261]
  • Jeong-Ah Kim, Edward K Lau, Li Pan, Esperanza J Carcache De Blanco. NF-kappaB inhibitors from Brucea javanica exhibiting intracellular effects on reactive oxygen species. Anticancer research. 2010 Sep; 30(9):3295-300. doi: . [PMID: 20944100]
  • N R Guz, F R Stermitz. Synthesis and structures of regioisomeric hydnocarpin-type flavonolignans. Journal of natural products. 2000 Aug; 63(8):1140-5. doi: 10.1021/np000166d. [PMID: 10978213]
  • D K Sharma, I H Hall. Hypolipidemic, anti-inflammatory, and antineoplastic activity and cytotoxicity of flavonolignans isolated from Hydnocarpus wightiana seeds. Journal of natural products. 1991 Sep; 54(5):1298-302. doi: 10.1021/np50077a010. [PMID: 1800632]