Classification Term: 167888
黄酮类 (ontology term: 9ed2fe8aa732234384f2801a47a920a4)
黄酮类物质是一大类天然有机化合物，广泛存在于植物界，特别是在蔬菜、水果、谷物和茶叶中。它们以其独特的化学结构和多样的生物活性而闻名。 化学结构： 黄酮类物质的基本结构是一个中央的苯环，两个苯环通过三个碳原子相互连接，形成一个C6-C3-C6的骨架。 这个骨架上的不同位置可以连接各种取代基，如羟基、甲基、甲氧基等，这些取代基的不同组合和位置导致了黄酮类物质的多样性。 分类： 黄酮类物质可以根据它们的结构特征进一步分为几个亚类，如黄酮、黄酮醇、异黄酮、查耳酮等。 每个亚类都有其特定的结构和生物活性。 生物活性： 抗氧化作用：黄酮类物质具有强大的抗氧化作用，可以清除体内的自由基，保护细胞免受氧化损伤。 抗炎作用：一些黄酮类物质具有抗炎作用，可以用于治疗炎症性疾病。 抗肿瘤作用：黄酮类物质具有抗肿瘤作用，可以抑制肿瘤细胞的生长和扩散。 心血管保护作用：黄酮类物质可以降低血压、降低胆固醇、抗血小板聚集等，对心血管系统具有保护作用。 其他作用：黄酮类物质还具有抗菌、抗病毒、抗过敏等多种生物活性。 代表性化合物： 儿茶素：是一种存在于茶叶中的黄酮类物质，具有抗氧化、抗炎、抗肿瘤等多种生物活性。 大豆异黄酮：是一种存在于大豆中的黄酮类物质，具有雌激素样作用，可以用于治疗更年期综合症等疾病。 槲皮素：是一种存在于许多水果和蔬菜中的黄酮醇类物质，具有抗氧化、抗炎、抗肿瘤等多种生物活性。 应用： 黄酮类物质在医药领域有着广泛的应用，如用于制备抗炎药物、抗肿瘤药物等。 在食品工业中，黄酮类物质也被用作食品添加剂，如抗氧化剂、色素等。 此外，黄酮类物质还在化妆品、农业等领域有着一定的应用。
found 49 associated metabolites at class metabolite taxonomy ontology rank level.
Child Taxonomies: 黄烷醇, 异黄酮, 黄烷类, 二氢黄酮醇, 聚黄酮类, 黃烷酮, 新黄酮类, 紫檀素, 查尔酮, 二氢黄酮, 黄酮, 异黄烷, 异黄烷酮, 类黄酮醇, 二氢查耳酮, 黄酮醇, 花青素, 原花青素, 二氢黄酮类, 橙酮, 双黄酮, 类黄酮, 黄酮苷
MethylophiopogononeA
Methylophiopogonone A is a homoisoflavonoid that is 4H-1-benzopyran-4-one substituted by hydroxy groups at positions 5 and 7, methyl groups at positions 6 and 8 and a (2H-1,3-benzodioxol-5-yl)methyl group at position 3 respectively. It has a role as a plant metabolite. It is a homoisoflavonoid and a member of resorcinols. Methylophiopogonone A is a natural product found in Ophiopogon japonicus, Arabidopsis thaliana, and Liriope muscari with data available. A homoisoflavonoid that is 4H-1-benzopyran-4-one substituted by hydroxy groups at positions 5 and 7, methyl groups at positions 6 and 8 and a (2H-1,3-benzodioxol-5-yl)methyl group at position 3 respectively. Methylophiopogonone A, a homoisoflavonoid isolated from the tuberous roots of Ophiopogon japonicas, shows anti-inflammatory activity[1]. Methylophiopogonone A, a homoisoflavonoid isolated from the tuberous roots of Ophiopogon japonicas, shows anti-inflammatory activity[1].
Sanggenon A
Sanggenon A is a member of chromenes. sanggenon A is a natural product found in Morus cathayana, Morus mongolica, and Morus alba with data available.
Rottlerin
Rottlerin is a chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis. It has a role as an antineoplastic agent, an apoptosis inducer, a metabolite, a K-ATP channel agonist, an antihypertensive agent and an anti-allergic agent. It is an enone, a chromenol, a benzenetriol, a methyl ketone and an aromatic ketone. Rottlerin is a natural product found in Mallotus philippensis with data available. A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis. D004791 - Enzyme Inhibitors relative retention time with respect to 9-anthracene Carboxylic Acid is 1.546 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.549 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.548 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.550 Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC50 values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation[1][2][3]. Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection[4][5]. Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC50 values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation[1][2][3]. Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection[4][5].
UNII:5K6L8O868Y
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.976 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.978 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.974 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.973 4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. 4'-Hydroxyflavanone is a synthetic analogue of flavanone, has potential for hepatic steatosis and dyslipidemia research[1]. 4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. 4'-Hydroxyflavanone is a synthetic analogue of flavanone, has potential for hepatic steatosis and dyslipidemia research[1]. 4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. 4'-Hydroxyflavanone is a synthetic analogue of flavanone, has potential for hepatic steatosis and dyslipidemia research[1].
Procyanidin B3
Procyanidin B3 is a proanthocyanidin consisting of two molecules of (+)-catechin joined by a bond between positions 4 and 8 in alpha-configuration. It can be found in red wine, in barley, in beer, in peach or in Jatropha macrantha, the Huanarpo Macho. It has a role as a metabolite, an antioxidant, an anti-inflammatory agent and an EC 2.3.1.48 (histone acetyltransferase) inhibitor. It is a hydroxyflavan, a proanthocyanidin, a biflavonoid and a polyphenol. It is functionally related to a (+)-catechin. Procyanidin B3 is a natural product found in Quercus dentata, Quercus miyagii, and other organisms with data available. Present in red wine. Occurs in Fragaria subspecies Procyanidin B3 is found in many foods, some of which are quince, strawberry, bilberry, and japanese persimmon. Procyanidin B3 is found in alcoholic beverages. Procyanidin B3 is present in red wine. Procyanidin B3 occurs in Fragaria species. Procyanidin B3 is a natural product, acts as a specific HAT inhibitor, binds to the other site of p300 instead of the active site, selectively inhibits p300-mediated androgen receptor acetylation. Procyanidin B3 has no effect on HDAC or HMT (histone methyltransferase)[1]. Procyanidin B3 is a natural product, acts as a specific HAT inhibitor, binds to the other site of p300 instead of the active site, selectively inhibits p300-mediated androgen receptor acetylation. Procyanidin B3 has no effect on HDAC or HMT (histone methyltransferase)[1].
Garcinone E
Garcinone E is a member of xanthones. Garcinone E is a natural product found in Garcinia xipshuanbannaensis, Pentadesma butyracea, and other organisms with data available. See also: Garcinia mangostana fruit rind (has part). Constituent of the fruit of Garcinia mangostana (mangosteen). Garcinone E is found in fruits and purple mangosteen. Garcinone E is found in fruits. Garcinone E is a constituent of the fruit of Garcinia mangostana (mangosteen).
Mangostanol
Constituent of Garcinia mangostana (mangosteen). Mangostanol is found in fruits and purple mangosteen. Mangostanol is found in fruits. Mangostanol is a constituent of Garcinia mangostana (mangosteen) Mangostanol is a natural product found in Garcinia and Garcinia mangostana with data available.
Stevenin
Stevenin is a polyphenol metabolite detected in biological fluids (PMID: 20428313). A polyphenol metabolite detected in biological fluids [PhenolExplorer]
Dihydrobaicalein
Dihydrobaicalein is a PLK1 Inhibitor with an IC50 of 6.3 μM. Dihydrobaicalein also inhibits VRK2 and PLK2. Dihydrobaicalein is a natural product that can be isolated from Scutellaria scandens[1]. Dihydrobaicalein is a PLK1 Inhibitor with an IC50 of 6.3 μM. Dihydrobaicalein also inhibits VRK2 and PLK2. Dihydrobaicalein is a natural product that can be isolated from Scutellaria scandens[1].
7-Hydroxy-5-methoxyflavan
7-Hydroxy-5-methoxyflavan is isolated from the pith of sago palm. Isolated from the pith of sago palm
MethylophiopogonanoneB
Methylophiopogonanone B is a natural product found in Ophiopogon japonicus and Polygonatum odoratum with data available. Methylophiopogonanone B, homoisoflavonoid, is extracted from the root of Ophiopogon japonicas, shows high antioxidant ability[1]. Methylophiopogonanone B increases GTP-Rho and acts via the Rho signaling pathway, inducing cell morphological change via actin cytoskeletal reorganization, including dendrite retraction and stress fiber formation[2]. Methylophiopogonanone B, homoisoflavonoid, is extracted from the root of Ophiopogon japonicas, shows high antioxidant ability[1]. Methylophiopogonanone B increases GTP-Rho and acts via the Rho signaling pathway, inducing cell morphological change via actin cytoskeletal reorganization, including dendrite retraction and stress fiber formation[2]. Methylophiopogonanone B, homoisoflavonoid, is extracted from the root of Ophiopogon japonicas, shows high antioxidant ability[1]. Methylophiopogonanone B increases GTP-Rho and acts via the Rho signaling pathway, inducing cell morphological change via actin cytoskeletal reorganization, including dendrite retraction and stress fiber formation[2].
Methylophiopogonanone A
Methylophiopogonanone A is a homoflavonoid. Methylophiopogonanone A is a natural product found in Ophiopogon japonicus with data available. Methylophiopogonanone A, a major homoisoflavonoid in Ophiopogon japonicas, has both anti-oxidative and anti-inflammatory properties[1]. Methylophiopogonanone A, a major homoisoflavonoid in Ophiopogon japonicas, has both anti-oxidative and anti-inflammatory properties[1].
6-Formylisoophiopogonanone A
Silibinin
Silibinin is a flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities. It has a role as an antioxidant, an antineoplastic agent, a hepatoprotective agent and a plant metabolite. It is a flavonolignan, a polyphenol, an aromatic ether, a benzodioxine and a secondary alpha-hydroxy ketone. Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin and others. Silibinin is presented as a mixture of two diastereomers, silybin A and silybin B, which are found in an approximately equimolar ratio. Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells. Silibinin is a natural product found in Aspergillus iizukae, Asteraceae, and other organisms with data available. Silymarin is a mixture of flavonolignans isolated from the milk thistle plant Silybum marianum. Silymarin may act as an antioxidant, protecting hepatic cells from chemotherapy-related free radical damage. This agent may also promote the growth of new hepatic cells. (NCI04) The major active component of silymarin flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum; it is used in the treatment of HEPATITIS; LIVER CIRRHOSIS; and CHEMICAL AND DRUG INDUCED LIVER INJURY, and has antineoplastic activity; silybins A and B are diastereomers. A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities. A - Alimentary tract and metabolism > A05 - Bile and liver therapy > A05B - Liver therapy, lipotropics > A05BA - Liver therapy D000970 - Antineoplastic Agents D020011 - Protective Agents (±)-Silybin is the racemate of Silybin (HY-N0779A). Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2]. Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2]. Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2]. Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration. Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.
Silidianin
Silidianin is a natural product found in Silybum eburneum and Silybum marianum with data available. C26170 - Protective Agent > C2081 - Hepatoprotective Agent Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 17.38?μM. Silydianin has inhibitory effect on the in vitro production and release of oxidative products[1][2][3]. Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 17.38?μM. Silydianin has inhibitory effect on the in vitro production and release of oxidative products[1][2][3].
gambogenic acid
Gambogenic acid is an active ingredient in gamboge, with anticancer activity. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination[1]. Gambogenic acid is an active ingredient in gamboge, with anticancer activity. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination[1].
4-O-Methylsappanol
3-[(3,4-Dihydroxyphenyl)methyl]-4-methoxy-2,4-dihydrochromene-3,7-diol is a natural product found in Biancaea decapetala and Biancaea sappan with data available.
1,11b-Dihydro-11b-hydroxymaackiain
13-Hydroxy-5,7,11,19-tetraoxapentacyclo[10.8.0.02,10.04,8.013,18]icosa-2,4(8),9,17-tetraen-16-one is a natural product found in Ononis viscosa with data available.
Amaronol B
(-)-2-((3,5-Dihydroxy-4-methoxyphenyl)methyl)-2,4,6-trihydroxy-3(2H)-benzofuranone is a member of aurones. Amaronol B is a natural product found in Pseudolarix amabilis and Larix kaempferi with data available.
Rhamnocitrin 3-glucoside-4-(2-dihydrophaseoylglucoside)
3-Hydroxy-5,7,4-trimethoxyflavone
3-Hydroxy-5,7,4′-trimethoxyflavone is a flavonol can be isolated from Cucubalus baccifer (L.)[1].
1,3,7-Trihydroxy-2-prenylxanthone
1,3,7-Trihydroxy-2-prenylxanthone is a natural product found in Hypericum chinense, Garcinia forbesii, and other organisms with data available.
1,6-Dihydroxy-3,5,7-trimethoxyxanthone
1,6-Dihydroxy-3,5,7-trimethoxyxanthen-9-one is a natural product found in Cystopteris fragilis and Polygala tenuifolia with data available.
Xanthone V1a
Xanthone V1a is a natural product found in Garcinia lancilimba, Maclura tricuspidata, and Vismia guineensis with data available.
Bavachromene
Bavachromene is a natural product found in Broussonetia papyrifera and Cullen corylifolium with data available.
3-Methoxyflavonol
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.241 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.240 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.247 3'-Methoxyflavonol is a selective agonist of neuromedin U 2 receptor (NMU2R).
3,4-Dihydroxyflavone
3',4'-Dihydroxyflavone is a flavonoid. 3',4'-Dihydroxyflavone has antiallergic activity with an IC50 value of 30 μM. 3',4'-Dihydroxyflavone can be used for the research of type I allergy[1]. 3',4'-Dihydroxyflavone is a flavonoid. 3',4'-Dihydroxyflavone has antiallergic activity with an IC50 value of 30 μM. 3',4'-Dihydroxyflavone can be used for the research of type I allergy[1].
5-Geranyl-5,7,2,4-tetrahydroxyflavone
5-Geranyl-5,7,2,4-tetrahydroxyflavone is a natural product found in Morus nigra with data available.
Monnieriside A
Monnieriside A is a natural product found in Cnidium monnieri with data available.
Delphinidin-3-sambubioside chloride
Tanshinone IIA anhydride
(R)-2-Isopropyl-8,8,8a-trimethyl-6,7,8,8a-tetrahydrophenanthrene-3,4-diol
Tupichinol C
Tupichinol C is a natural product found in Soymida febrifuga and Broussonetia kazinoki with data available.
Demethylwedelolactone Sulfate
Lagosa
Silibinin B is a natural product found in Nymphaea alba, Aspergillus iizukae, and other organisms with data available. The major active component of silymarin flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum; it is used in the treatment of HEPATITIS; LIVER CIRRHOSIS; and CHEMICAL AND DRUG INDUCED LIVER INJURY, and has antineoplastic activity; silybins A and B are diastereomers. See also: Milk Thistle (part of).
3-Hydroxyflavone
Flavonol is an endogenous metabolite. Flavonol is an endogenous metabolite.
2-Hydroxychalcone
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3]. 2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].