Luteolin 7-galactoside (BioDeep_00000035636)

Main id: BioDeep_00000000277

 

human metabolite PANOMIX_OTCML-2023 BioNovoGene_Lab2019 natural product


代谢物信息卡片


2-(3,4-dihydroxyphenyl)-5-hydroxy-7-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-one

化学式: C21H20O11 (448.1006)
中文名称: 木犀草苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)OC4C(C(C(C(O4)CO)O)O)O)O)O)O
InChI: InChI=1S/C21H20O11/c22-7-16-18(27)19(28)20(29)21(32-16)30-9-4-12(25)17-13(26)6-14(31-15(17)5-9)8-1-2-10(23)11(24)3-8/h1-6,16,18-25,27-29H,7H2

描述信息

Luteolin 7-galactoside is found in fruits. Luteolin 7-galactoside is isolated from Capsella bursa-pastoris (shepherds purse).
Isolated from Capsella bursa-pastoris (shepherds purse). Luteolin 7-galactoside is found in herbs and spices and fruits.

同义名列表

3 个代谢物同义名

2-(3,4-dihydroxyphenyl)-5-hydroxy-7-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-one; Luteolin 7-galactoside; Cynaroside



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

562 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AKR1B1, ANXA5, CASP3, CASP8, EGFR, MAPK10, MYD88, NLRP3, TLR4
Peripheral membrane protein 1 ANXA5
Endosome membrane 3 EGFR, MYD88, TLR4
Endoplasmic reticulum membrane 1 EGFR
Nucleus 6 CASP3, CASP8, EGFR, MAPK10, MYD88, NLRP3
cytosol 8 AKR1B1, ANXA5, CASP3, CASP8, MAPK10, MYD88, NGF, NLRP3
dendrite 1 NGF
nucleoplasm 4 AKR1B1, CASP3, CASP8, MAPK10
Cell membrane 3 EGFR, TLR4, TNF
Lipid-anchor 1 MAPK10
lamellipodium 1 CASP8
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Golgi apparatus membrane 1 NLRP3
cell junction 1 EGFR
cell surface 4 EGFR, MYD88, TLR4, TNF
glutamatergic synapse 2 CASP3, EGFR
Golgi membrane 2 EGFR, NLRP3
lysosomal membrane 1 GAA
neuronal cell body 2 CASP3, TNF
sarcolemma 1 ANXA5
synaptic vesicle 1 NGF
Cytoplasm, cytosol 1 NLRP3
Lysosome 1 GAA
endosome 1 EGFR
plasma membrane 6 EGFR, GAA, MAPK10, MYD88, TLR4, TNF
Membrane 6 ANXA5, EGFR, GAA, MAPK10, NLRP3, TLR4
apical plasma membrane 1 EGFR
axon 1 NGF
basolateral plasma membrane 1 EGFR
extracellular exosome 3 AKR1B1, ANXA5, GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 1 NLRP3
extracellular space 4 AKR1B1, EGFR, NGF, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 EGFR, TLR4
mitochondrion 4 AKR1B1, CASP8, MAPK10, NLRP3
protein-containing complex 3 CASP8, EGFR, MYD88
intracellular membrane-bounded organelle 1 GAA
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 EGFR, TLR4
Secreted 3 GAA, NGF, NLRP3
extracellular region 5 ANXA5, GAA, NGF, NLRP3, TNF
mitochondrial outer membrane 1 CASP8
nuclear membrane 1 EGFR
external side of plasma membrane 3 ANXA5, TLR4, TNF
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cell projection, lamellipodium 1 CASP8
Membrane raft 2 EGFR, TNF
focal adhesion 2 ANXA5, EGFR
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 1 ANXA5
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 EGFR, TLR4
Zymogen granule membrane 1 ANXA5
phagocytic cup 2 TLR4, TNF
cytoskeleton 1 CASP8
Endomembrane system 1 NLRP3
endosome lumen 1 NGF
microtubule organizing center 1 NLRP3
tertiary granule membrane 1 GAA
cell body 1 CASP8
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
lipopolysaccharide receptor complex 1 TLR4
Golgi lumen 1 NGF
azurophil granule membrane 1 GAA
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 EGFR
extrinsic component of cytoplasmic side of plasma membrane 1 MYD88
ficolin-1-rich granule membrane 1 GAA
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
extrinsic component of plasma membrane 1 MYD88
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
endothelial microparticle 1 ANXA5
autolysosome lumen 1 GAA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Agung Nugroho, Myung-Hoe Kim, Jongwon Choi, Nam-In Baek, Hee-Juhn Park. In vivo sedative and gastroprotective activities of Salvia plebeia extract and its composition of polyphenols. Archives of pharmacal research. 2012 Aug; 35(8):1403-11. doi: 10.1007/s12272-012-0810-7. [PMID: 22941483]
  • Yong Huang, Feng He, Lin Zheng, Zhirong Zhang, Yanyu Lan, Yonglin Wang. [Simultaneous determination of isoorientin, scutellarin and cynaroside in rat plasma and pharmacokinetics by UPLC-MS/MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Feb; 37(4):529-32. doi: . [PMID: 22667158]
  • Wei-Jian Bei, Jiao Guo, Hai-Yun Wu, Yang Cao. Lipid-regulating effect of traditional chinese medicine: mechanisms of actions. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):970635. doi: 10.1155/2012/970635. [PMID: 22611438]
  • Nilufar Z Mamadalieva, Florian Herrmann, Mahmoud Z El-Readi, Ahmad Tahrani, Razan Hamoud, Dilfuza R Egamberdieva, Shahnoz S Azimova, Michael Wink. Flavonoids in Scutellaria immaculata and S. ramosissima (Lamiaceae) and their biological activity. The Journal of pharmacy and pharmacology. 2011 Oct; 63(10):1346-57. doi: 10.1111/j.2042-7158.2011.01336.x. [PMID: 21899551]
  • Xiao Sun, Gui-Bo Sun, Min Wang, Jing Xiao, Xiao-Bo Sun. Protective effects of cynaroside against H₂O₂-induced apoptosis in H9c2 cardiomyoblasts. Journal of cellular biochemistry. 2011 Aug; 112(8):2019-29. doi: 10.1002/jcb.23121. [PMID: 21445859]
  • S Saeidnia, Ar Gohari, N Mokhber-Dezfuli, F Kiuchi. A review on phytochemistry and medicinal properties of the genus Achillea. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2011; 19(3):173-86. doi: ". [PMID: 22615655]
  • Ning Xia, Larissa Bollinger, Katja Steinkamp-Fenske, Ulrich Förstermann, Huige Li. Prunella vulgaris L. Upregulates eNOS expression in human endothelial cells. The American journal of Chinese medicine. 2010; 38(3):599-611. doi: 10.1142/s0192415x10008081. [PMID: 20503475]
  • Michał Wolniak, Monika Tomczykowa, Michał Tomczyk, Jan Gudej, Iwona Wawer. Antioxidant activity of extracts and flavonoids from Bidens tripartita. Acta poloniae pharmaceutica. 2007 Sep; 64(5):441-7. doi: ". [PMID: 18540165]
  • Ju Sun Kim, Jin Cheul Kim, Sang Hee Shim, Eun Ju Lee, WenYi Jin, KiHwan Bae, Kun Ho Son, Hyun Pyo Kim, Sam Sik Kang, Hyeun Wook Chang. Chemical constituents of the root of Dystaenia takeshimana and their anti-inflammatory activity. Archives of pharmacal research. 2006 Aug; 29(8):617-23. doi: 10.1007/bf02968244. [PMID: 16964755]
  • G Odontuya, J R S Hoult, P J Houghton. Structure-activity relationship for antiinflammatory effect of luteolin and its derived glycosides. Phytotherapy research : PTR. 2005 Sep; 19(9):782-6. doi: 10.1002/ptr.1723. [PMID: 16220571]
  • Xianfeng Zhu, Hongxun Zhang, Raymond Lo. Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities. Journal of agricultural and food chemistry. 2004 Dec; 52(24):7272-8. doi: 10.1021/jf0490192. [PMID: 15563206]
  • Huige Li, Ning Xia, Isolde Brausch, Ying Yao, Ulrich Förstermann. Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells. The Journal of pharmacology and experimental therapeutics. 2004 Sep; 310(3):926-32. doi: 10.1124/jpet.104.066639. [PMID: 15123766]
  • Rolf Gebhardt. Inhibition of cholesterol biosynthesis in HepG2 cells by artichoke extracts is reinforced by glucosidase pretreatment. Phytotherapy research : PTR. 2002 Jun; 16(4):368-72. doi: 10.1002/ptr.960. [PMID: 12112295]
  • Jong Cheol Park, Ju Gwon Park, Hyun Joo Kim, Jong Moon Hur, Jong Ho Lee, Nak Ju Sung, Shin Kyo Chung, Jong Won Choi. Effects of extract from Angelica keiskei and its component, cynaroside, on the hepatic bromobenzene-metabolizing enzyme system in rats. Phytotherapy research : PTR. 2002 Mar; 16 Suppl 1(?):S24-7. doi: 10.1002/ptr.783. [PMID: 11933135]
  • C Q Hu, K Chen, Q Shi, R E Kilkuskie, Y C Cheng, K H Lee. Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids. Journal of natural products. 1994 Jan; 57(1):42-51. doi: 10.1021/np50103a006. [PMID: 8158164]