Harmine (BioDeep_00000000782)

 

Secondary id: BioDeep_00000324323, BioDeep_00000399223, BioDeep_00000866797

human metabolite PANOMIX_OTCML-2023 Endogenous Antitumor activity natural product


代谢物信息卡片


InChI=1/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H

化学式: C13H12N2O (212.095)
中文名称: 哈尔明碱, 哈尔碱, 去氢骆驼蓬碱, 肉叶芸香碱
谱图信息: 最多检出来源 Viridiplantae(plant) 12%

分子结构信息

SMILES: CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC
InChI: InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3

描述信息

Harmine is a harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7. It has a role as a metabolite, an anti-HIV agent and an EC 1.4.3.4 (monoamine oxidase) inhibitor. It derives from a hydride of a harman.
Harmine is a natural product found in Thalictrum foetidum, Acraea andromacha, and other organisms with data available.
Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic PARKINSON DISEASE in the 1920s.
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D006213 - Hallucinogens
Harmine is found in fruits. Harmine is an alkaloid from Passiflora edulis (passionfruit
A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7.
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
CONFIDENCE Reference Standard (Level 1); NaToxAq - Natural Toxins and Drinking Water Quality - From Source to Tap (https://natoxaq.ku.dk)
[Raw Data] CB043_Harmine_pos_40eV_CB000020.txt
[Raw Data] CB043_Harmine_pos_50eV_CB000020.txt
[Raw Data] CB043_Harmine_pos_10eV_CB000020.txt
[Raw Data] CB043_Harmine_pos_30eV_CB000020.txt
[Raw Data] CB043_Harmine_pos_20eV_CB000020.txt
CONFIDENCE standard compound; INTERNAL_ID 2884
[Raw Data] CB043_Harmine_neg_50eV_000013.txt
[Raw Data] CB043_Harmine_neg_30eV_000013.txt
[Raw Data] CB043_Harmine_neg_10eV_000013.txt
[Raw Data] CB043_Harmine_neg_20eV_000013.txt
[Raw Data] CB043_Harmine_neg_40eV_000013.txt
Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].
Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].
Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1].

同义名列表

62 个代谢物同义名

InChI=1/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H; 7-methoxy-1-methyl-9H-beta-carboline;hydrochloride; 7-METHOXY-1-METHYL-9H-PYRIDO[3,4-B]INDOL; HARMINE; 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole, 9CI; 5-23-12-00237 (Beilstein Handbook Reference); 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-; 9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl-; 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole; 7-Methoxy-1-methyl-9H-pyrido(3,4-b)indole; 7-Methoxy-1-methyl-9H-beta-carboline #; 7-Methoxy-1-methyl-9H-beta-carboline; 1-Methyl-7-methoxy-.beta.-carboline; 1-Methyl-7-methoxy-beta -carboline; 1-Methyl-7-methoxy-beta-carboline; 7-Methoxy-1-methyl-9H-β-carboline; 7-Methoxy-1-methyl-9H-b-carboline; 7-methoxy-1-methylbeta-carboline; Harmine (Telepathine); Harmin hydrochloride; 442-51-3 (FREE base); Prestwick0_000613; Prestwick3_000613; Prestwick1_000613; Prestwick2_000613; Spectrum2_000568; Spectrum4_001004; Spectrum5_001914; Spectrum3_000906; UNII-4FHH5G48T7; 6-Methoxyharman; HARMINE [MART.]; Harmine, 98\\%; DivK1c_006707; MEGxp0_001875; Oprea1_596686; BPBio1_000602; KBio2_001608; KBio2_006744; KBio1_001651; ACon0_001194; Leucoharmine; ACon1_000061; HARMINE [MI]; KBio2_004176; KBio3_001852; Telepathine; Banisterine; Telepathien; 4FHH5G48T7; Banisterin; Telepathin; A1-03319; Yageine; Harmine; Yajeine; Garmin; Yagein; Harmin; 3anr; HRM; Harmine; Harmine



数据库引用编号

73 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(2)

代谢反应

9 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(6)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(3)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

268 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AKT1, BCL2, BDNF, CTNNB1, DYRK1A, MAPK14, MTOR, PRKX, TP53, TYR
Peripheral membrane protein 2 ACHE, MTOR
Endoplasmic reticulum membrane 3 BCL2, HSP90B1, MTOR
Mitochondrion membrane 1 MAOA
Nucleus 12 ACHE, AKT1, BCL2, CTNNB1, DYRK1A, HSP90B1, MAPK14, MTOR, PARP1, PRKX, TP53, TWIST1
cytosol 9 AKT1, BCL2, CTNNB1, HSP90B1, MAOA, MAPK14, MTOR, PARP1, TP53
dendrite 3 BDNF, DYRK1A, MTOR
nuclear body 1 PARP1
phagocytic vesicle 1 MTOR
centrosome 2 CTNNB1, TP53
nucleoplasm 9 AKT1, CTNNB1, DYRK1A, MAPK14, MTOR, PARP1, PRKX, TP53, TWIST1
Cell membrane 5 ACHE, AKT1, CTNNB1, SLC1A2, TNF
Cytoplasmic side 2 MAOA, MTOR
lamellipodium 2 AKT1, CTNNB1
Multi-pass membrane protein 1 SLC1A2
Golgi apparatus membrane 1 MTOR
Synapse 2 ACHE, CTNNB1
cell cortex 2 AKT1, CTNNB1
cell junction 1 CTNNB1
cell surface 3 ACHE, SLC1A2, TNF
glutamatergic synapse 4 AKT1, CTNNB1, MAPK14, SLC1A2
Golgi apparatus 1 ACHE
Golgi membrane 2 INS, MTOR
lysosomal membrane 1 MTOR
neuromuscular junction 1 ACHE
neuronal cell body 1 TNF
postsynapse 1 AKT1
presynaptic membrane 2 CTNNB1, SLC1A2
smooth endoplasmic reticulum 1 HSP90B1
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 PARP1
Lysosome 2 MTOR, TYR
plasma membrane 5 ACHE, AKT1, CTNNB1, SLC1A2, TNF
Membrane 11 ACHE, AKT1, BCL2, BDNF, CTNNB1, HSP90B1, MAOA, MTOR, PARP1, SLC1A2, TP53
axon 2 BDNF, DYRK1A
basolateral plasma membrane 1 CTNNB1
extracellular exosome 3 BMP3, CTNNB1, HSP90B1
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, HSP90B1, TP53
extracellular space 6 ACHE, BDNF, BMP3, IL6, INS, TNF
perinuclear region of cytoplasm 5 ACHE, BDNF, CTNNB1, HSP90B1, TYR
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
mitochondrion 5 BCL2, MAOA, MAPK14, PARP1, TP53
protein-containing complex 6 AKT1, BCL2, CTNNB1, HSP90B1, PARP1, TP53
intracellular membrane-bounded organelle 1 TYR
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TYR
Secreted 5 ACHE, BDNF, BMP3, IL6, INS
extracellular region 8 ACHE, BDNF, BMP3, HSP90B1, IL6, INS, MAPK14, TNF
Mitochondrion outer membrane 3 BCL2, MAOA, MTOR
Single-pass membrane protein 2 BCL2, MAOA
mitochondrial outer membrane 3 BCL2, MAOA, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
Extracellular side 1 ACHE
transcription regulator complex 3 CTNNB1, PARP1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 1 AKT1
nucleolus 2 PARP1, TP53
Wnt signalosome 1 CTNNB1
Melanosome membrane 1 TYR
midbody 1 HSP90B1
apical part of cell 1 CTNNB1
cell-cell junction 2 AKT1, CTNNB1
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 AKT1, SLC1A2
postsynaptic membrane 1 CTNNB1
Membrane raft 2 SLC1A2, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 2 CTNNB1, TP53
focal adhesion 2 CTNNB1, HSP90B1
spindle 1 AKT1
axolemma 1 SLC1A2
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
basement membrane 1 ACHE
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 HSP90B1
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
nuclear speck 2 DYRK1A, MAPK14
ciliary basal body 1 AKT1
chromatin 3 PARP1, TP53, TWIST1
phagocytic cup 1 TNF
cell periphery 1 CTNNB1
Chromosome 1 PARP1
cytoskeleton 1 DYRK1A
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Nucleus, nucleolus 1 PARP1
spindle pole 2 CTNNB1, MAPK14
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
postsynaptic density, intracellular component 1 CTNNB1
Lipid-anchor, GPI-anchor 1 ACHE
microvillus membrane 1 CTNNB1
site of double-strand break 2 PARP1, TP53
nuclear envelope 2 MTOR, PARP1
Endomembrane system 2 CTNNB1, MTOR
endosome lumen 1 INS
Melanosome 2 HSP90B1, TYR
Nucleus speckle 1 DYRK1A
euchromatin 1 CTNNB1
cell body 1 SLC1A2
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
sperm plasma membrane 1 HSP90B1
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 BDNF, HSP90B1, IL6, INS
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
transport vesicle 1 INS
beta-catenin-TCF complex 1 CTNNB1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 MAOA
presynaptic active zone cytoplasmic component 1 CTNNB1
Sarcoplasmic reticulum lumen 1 HSP90B1
ribonucleoprotein complex 1 DYRK1A
[Isoform 1]: Nucleus 1 TP53
synaptic cleft 1 ACHE
protein-DNA complex 2 CTNNB1, PARP1
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
site of DNA damage 1 PARP1
astrocyte projection 1 SLC1A2
endocytic vesicle lumen 1 HSP90B1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 HSP90B1
neuron projection terminus 1 SLC1A2
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
beta-catenin-TCF7L2 complex 1 CTNNB1
[Isoform H]: Cell membrane 1 ACHE
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
membrane protein complex 1 SLC1A2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Eleanor White, Tom Kennedy, Simon Ruffell, Daniel Perkins, Jerome Sarris. Ayahuasca and Dimethyltryptamine Adverse Events and Toxicity Analysis: A Systematic Thematic Review. International journal of toxicology. 2024 May; 43(3):327-339. doi: 10.1177/10915818241230916. [PMID: 38363085]
  • Ya-Li Guo, Jing-Wen Yu, Yan Cao, Ke-Xin Cheng, Suo-Nan-Mu Dong-Zhi, Yan-Fei Zhang, Qing-Jia Ren, Yong Yin, Cao-Long Li. Design, synthesis, and biological evaluation of harmine derivatives as topoisomerase I inhibitors for cancer treatment. European journal of medicinal chemistry. 2024 Feb; 265(?):116061. doi: 10.1016/j.ejmech.2023.116061. [PMID: 38154256]
  • Phumudzo P Tshikhudo, Tafadzwanashe Mabhaudhi, Neil A Koorbanally, Fhatuwani N Mudau, Edgardo Oscar Avendaño Caceres, Dragos Popa, Daniela Calina, Javad Sharifi-Rad. Anticancer Potential of β-Carboline Alkaloids: An Updated Mechanistic Overview. Chemistry & biodiversity. 2023 Dec; ?(?):e202301263. doi: 10.1002/cbdv.202301263. [PMID: 38108650]
  • Lei Zhang, Yuan Li, Wenqing Yang, Lin Lin, Jie Li, Dekun Liu, Chao Li, Jibiao Wu, Yunlun Li. Protocatechuic aldehyde increases pericyte coverage and mitigates pericyte damage to enhance the atherosclerotic plaque stability. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 168(?):115742. doi: 10.1016/j.biopha.2023.115742. [PMID: 37871558]
  • Ahmed H Abdelazim, Majed A Algarni, Atiah H Almalki. Innovative spectrofluorometric method for determination of harmaline and harmine in different matrices. Scientific reports. 2023 11; 13(1):19951. doi: 10.1038/s41598-023-46041-y. [PMID: 37968310]
  • Yangjing Bai, Shiying Lang, Yangrui Du, Qinsheng Hu, Xinyun Li, Gongyan Liu. Metallic-Polyphenolic Nanoparticles Reinforced Cationic Guar Gum Hydrogel for Effectively Treating Burn Wound. Macromolecular bioscience. 2023 Oct; ?(?):e2300396. doi: 10.1002/mabi.202300396. [PMID: 37831011]
  • Shao-Ru Wu, Wei-Hong Feng, Kai-Ming Chen, Liang-Jun Guan, Liang-Mian Chen, Zhi-Min Wang, Hui-Min Gao, Zong-Hua Song. [Chemical composition and antioxidant activity of different parts of Prunella vulgaris by UPLC-Q-TOF-MS/MS and UPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Sep; 48(17):4569-4588. doi: 10.19540/j.cnki.cjcmm.20221227.202. [PMID: 37802797]
  • Bao Tan Nguyen, Nguyen Thi Hai Yen, Ninh Khac Thanh Tung, Gil-Saeng Jeong, Jong Seong Kang, Nguyen Phuoc Long, Hyung Min Kim. Lipid class-dependent alterations of Caenorhabditis elegans under harmane exposure. Journal of pharmaceutical and biomedical analysis. 2023 Jul; 231(?):115401. doi: 10.1016/j.jpba.2023.115401. [PMID: 37105045]
  • Chunliu Wang, Jie Zhou, Shixiang Wang, Yang Liu, Kaihua Long, Tingting Sun, Wenbing Zhi, Yang Yang, Hong Zhang, Ye Zhao, Xiaopu Zheng, Xiaohui Zheng, Ye Li, Pu Jia. Guanxining injection alleviates fibrosis in heart failure mice and regulates SLC7A11/GPX4 axis. Journal of ethnopharmacology. 2023 Jun; 310(?):116367. doi: 10.1016/j.jep.2023.116367. [PMID: 36914037]
  • Junxia Pei, Zhou Su, Xin Zeng, Ya Zhong, Yamei Zhang, Yixi Yang, Qiuxia Lu, Jian Li, Yu Deng. Protocatechuic aldehyde acts synergistically with dacarbazine to augment DNA double-strand breaks and promote apoptosis in cutaneous melanoma cells. BMC complementary medicine and therapies. 2023 Apr; 23(1):111. doi: 10.1186/s12906-023-03933-w. [PMID: 37024907]
  • Yuanyuan Wang, Maofeng Dong, Limin Guo, Yamin Zhu, Qingqing Jiang, Jianbo Xiao, Mingfu Wang, Yueliang Zhao. Effect of acrolein on the formation of harman and norharman in chemical models and roast beef patties. Food research international (Ottawa, Ont.). 2023 02; 164(?):112465. doi: 10.1016/j.foodres.2023.112465. [PMID: 36738015]
  • Summya Rashid, Maryam Sameti, Mohammed H Alqarni, Fatma M Abdel Bar. In vivo investigation of the inhibitory effect of Peganum harmala L. and its major alkaloids on ethylene glycol-induced urolithiasis in rats. Journal of ethnopharmacology. 2023 Jan; 300(?):115752. doi: 10.1016/j.jep.2022.115752. [PMID: 36174807]
  • Pengjun Wang, Qingxiang Zhang. Protocatechuic aldehyde alleviates D-galactose-induced cardiomyocyte senescence by regulating the TCF3 / ATG5 axis. Journal of cardiovascular pharmacology. 2022 Dec; ?(?):. doi: 10.1097/fjc.0000000000001394. [PMID: 36651950]
  • Xin-Yu Lin, Jing Zhou, Cai-Feng Hao, He Zhu, Shan-Shan Zhou, Jin-Di Xu, Qian Mao, Song-Lin Li, Ming Kong. Quality consistency evaluation of commercial Prunellae Spica by integrating determination of secondary metabolites and saccharides. Phytochemical analysis : PCA. 2022 Dec; ?(?):. doi: 10.1002/pca.3197. [PMID: 36494085]
  • Yu-Teng Chang, Mu-Chi Chung, Chi-Hao Chang, Kuan-Hsun Chiu, Jeng-Jer Shieh, Ming-Ju Wu. Anti-EMT and anti-fibrosis effects of protocatechuic aldehyde in renal proximal tubular cells and the unilateral ureteral obstruction animal model. Pharmaceutical biology. 2022 Dec; 60(1):1198-1206. doi: 10.1080/13880209.2022.2088809. [PMID: 35758295]
  • Dongyan Hu, Guangtian Han, Huazhong Ren, Xinwei Li, Xi'an Li, Lirong Yue, Jiao Xu, Jiafu Feng, Li Guo. Synthesis, biological evaluation and preliminary mechanisms of 6-amino substituted harmine derivatives as potential antitumor agents. Fitoterapia. 2022 Nov; 163(?):105329. doi: 10.1016/j.fitote.2022.105329. [PMID: 36209955]
  • Albert Katchborian-Neto, Mário Ferreira Conceição Santos, Diego Fernandes Vilas-Boas, Elda Gonçalves Dos Santos, Márcia Paranho Veloso, Paula Carolina Pires Bueno, Ivo Santana Caldas, Marisi Gomes Soares, Danielle Ferreira Dias, Daniela Aparecida Chagas-Paula. Immunological Modulation and Control of Parasitaemia by Ayahuasca Compounds: Therapeutic Potential for Chagas's Disease. Chemistry & biodiversity. 2022 Oct; 19(10):e202200409. doi: 10.1002/cbdv.202200409. [PMID: 36163588]
  • Lucia Jimenez, Andreia Silva, Giampaolo Calissi, Inês Grenho, Rita Monteiro, Victor Mayoral-Varo, Carmen Blanco-Aparicio, Joaquin Pastor, Victor Bustos, Franz Bracher, Diego Megías, Bibiana I Ferreira, Wolfgang Link. Screening Health-Promoting Compounds for Their Capacity to Induce the Activity of FOXO3. The journals of gerontology. Series A, Biological sciences and medical sciences. 2022 08; 77(8):1485-1493. doi: 10.1093/gerona/glab265. [PMID: 34508571]
  • Zhezhe Li, Yipaerguli Apizi, Chengzhong Zhang, Zhaozhi Wang, Hongji He, Xiaoya Li, Yina Zhu, Jishun Yang, Liang Xiao, Mei Wang. Synthesis of harmine-nitric oxide donor derivatives as potential antitumor agents. Bioorganic & medicinal chemistry letters. 2022 06; 65(?):128698. doi: 10.1016/j.bmcl.2022.128698. [PMID: 35341920]
  • Caizhi Tian, Shuoqi Huang, Zihua Xu, Wenwu Liu, Deping Li, Mingyue Liu, Chengze Zhu, Limeng Wu, Xiaowen Jiang, Huaiwei Ding, Qingchun Zhao. Design, synthesis, and biological evaluation of β-carboline 1,3,4-oxadiazole based hybrids as HDAC inhibitors with potential antitumor effects. Bioorganic & medicinal chemistry letters. 2022 05; 64(?):128663. doi: 10.1016/j.bmcl.2022.128663. [PMID: 35272009]
  • Soching Luikham, Mavani A, Jhimli Bhattacharyya. Deciphering binding affinity, energetics, and base specificity of plant alkaloid Harmane with AT and GC hairpin duplex DNA. Luminescence : the journal of biological and chemical luminescence. 2022 May; 37(5):691-701. doi: 10.1002/bio.4210. [PMID: 35156295]
  • Nikhil Maheshwari, Riaz Mahmood. 3,4-Dihydroxybenzaldehyde attenuates pentachlorophenol-induced cytotoxicity, DNA damage and collapse of mitochondrial membrane potential in isolated human blood cells. Drug and chemical toxicology. 2022 May; 45(3):1225-1242. doi: 10.1080/01480545.2020.1811722. [PMID: 32854525]
  • Shi-Ming Huang, Shu-Bei Li, Hong-Tao Deng, Qing-Qing Jiang, Yi-Bo Gu, Xue Ying. [Preparation and effect against cervical cancer invasion in vitro of harmine-loaded photosensitive liposomes]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 May; 47(10):2643-2651. doi: 10.19540/j.cnki.cjcmm.20210520.301. [PMID: 35718482]
  • Beatriz Werneck Lopes Santos, Daniel Carneiro Moreira, Tatiana Karla Dos Santos Borges, Eloisa Dutra Caldas. Components of Banisteriopsis caapi, a Plant Used in the Preparation of the Psychoactive Ayahuasca, Induce Anti-Inflammatory Effects in Microglial Cells. Molecules (Basel, Switzerland). 2022 Apr; 27(8):. doi: 10.3390/molecules27082500. [PMID: 35458698]
  • You-Xu Wang, Ning Cao, Hui-Da Guan, Xue-Mei Cheng, Chang-Hong Wang. Heme peroxidases are responsible for the dehydrogenation and oxidation metabolism of harmaline into harmine. Chinese journal of natural medicines. 2022 Mar; 20(3):194-201. doi: 10.1016/s1875-5364(22)60151-1. [PMID: 35369963]
  • Eun-A Kim, Eui-Jeong Han, Junseong Kim, Ilekuttige Priyan Shanura Fernando, Jae-Young Oh, Kil-Nam Kim, Ginnae Ahn, Soo-Jin Heo. Anti-Allergic Effect of 3,4-Dihydroxybenzaldehyde Isolated from Polysiphonia morrowii in IgE/BSA-Stimulated Mast Cells and a Passive Cutaneous Anaphylaxis Mouse Model. Marine drugs. 2022 Feb; 20(2):. doi: 10.3390/md20020133. [PMID: 35200662]
  • Weiyi Qu, Ze Chen, Xing Hu, Toujun Zou, Yongping Huang, Yanyan Zhang, Yufeng Hu, Song Tian, Juan Wan, Rufang Liao, Lan Bai, Jinhua Xue, Yi Ding, Manli Hu, Xiao-Jing Zhang, Xin Zhang, Jingjing Zhao, Xu Cheng, Zhi-Gang She, Hongliang Li. Profound Perturbation in the Metabolome of a Canine Obesity and Metabolic Disorder Model. Frontiers in endocrinology. 2022; 13(?):849060. doi: 10.3389/fendo.2022.849060. [PMID: 35620391]
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