Kuromanin (BioDeep_00001868657)

Main id: BioDeep_00000003546

 

PANOMIX_OTCML-2023 PANOMIX-Anthocyanidin BioNovoGene_Lab2019


代谢物信息卡片


Kuromanin

化学式: C21H21O11+ (449.1084)
中文名称: 矢车菊素3-O-葡萄糖苷, 矢车菊素-3-O-葡萄糖苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1C2=[O+]C3=CC(=CC(=C3C=C2OC4C(C(C(C(O4)CO)O)O)O)O)O)O)O
InChI: InChI=1S/C21H20O11/c22-7-16-17(27)18(28)19(29)21(32-16)31-15-6-10-12(25)4-9(23)5-14(10)30-20(15)8-1-2-11(24)13(26)3-8/h1-6,16-19,21-22,27-29H,7H2,(H3-,23,24,25,26)/p+1/t16-,17-,18+,19-,21-/m1/s1

描述信息

同义名列表

2 个代谢物同义名

Kuromanin; Chrysanthemin



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

240 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 BCL2, CASP3, CAT, CDH1, CTNNB1, HPGDS, MAPK14, MAPK8, NFE2L2, NOS3, PIK3CA, PPARG, PTGS2, TYR
Peripheral membrane protein 2 GORASP1, PTGS2
Endoplasmic reticulum membrane 3 BCL2, HMOX1, PTGS2
Nucleus 10 BCL2, CASP3, CDH1, CTNNB1, HMOX1, MAPK14, MAPK8, NFE2L2, NOS3, PPARG
cytosol 13 BCL2, CASP3, CAT, CDH1, CTNNB1, HMOX1, HPGDS, MAPK14, MAPK8, NFE2L2, NOS3, PIK3CA, PPARG
trans-Golgi network 1 CDH1
centrosome 2 CTNNB1, NFE2L2
nucleoplasm 10 CASP3, CDH1, CTNNB1, HMOX1, HPGDS, MAPK14, MAPK8, NFE2L2, NOS3, PPARG
RNA polymerase II transcription regulator complex 2 NFE2L2, PPARG
Cell membrane 3 CDH1, CTNNB1, TNF
Cytoplasmic side 2 GORASP1, HMOX1
lamellipodium 3 CDH1, CTNNB1, PIK3CA
Golgi apparatus membrane 1 GORASP1
Synapse 2 CTNNB1, MAPK8
cell cortex 1 CTNNB1
cell junction 2 CDH1, CTNNB1
cell surface 1 TNF
glutamatergic synapse 4 CASP3, CDH1, CTNNB1, MAPK14
Golgi apparatus 4 CDH1, GORASP1, NFE2L2, NOS3
Golgi membrane 3 GORASP1, INS, NOS3
lysosomal membrane 1 GAA
neuronal cell body 2 CASP3, TNF
postsynapse 1 CDH1
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 1 NFE2L2
Lysosome 2 GAA, TYR
endosome 1 CDH1
plasma membrane 7 CDH1, CTNNB1, GAA, NFE2L2, NOS3, PIK3CA, TNF
Membrane 6 BCL2, CAT, CDH1, CTNNB1, GAA, HMOX1
axon 1 MAPK8
basolateral plasma membrane 1 CTNNB1
caveola 2 NOS3, PTGS2
extracellular exosome 4 CAT, CDH1, CTNNB1, GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 3 BCL2, HMOX1, PTGS2
extracellular space 4 HMOX1, IL6, INS, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 7 CDH1, CTNNB1, HMOX1, NOS3, PIK3CA, PPARG, TYR
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 2 CDH1, CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, CAT, MAPK14
protein-containing complex 4 BCL2, CAT, CTNNB1, PTGS2
intracellular membrane-bounded organelle 5 CAT, GAA, HPGDS, PPARG, TYR
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 CDH1, TYR
Secreted 3 GAA, IL6, INS
extracellular region 7 CAT, CDH1, GAA, IL6, INS, MAPK14, TNF
cytoplasmic side of plasma membrane 1 CDH1
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
mitochondrial matrix 1 CAT
transcription regulator complex 1 CTNNB1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CDH1
external side of plasma membrane 1 TNF
actin cytoskeleton 1 CDH1
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
Wnt signalosome 1 CTNNB1
Melanosome membrane 1 TYR
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 CTNNB1
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 2 CAT, CTNNB1
cis-Golgi network 1 GORASP1
Cell junction, adherens junction 2 CDH1, CTNNB1
flotillin complex 2 CDH1, CTNNB1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
fascia adherens 1 CTNNB1
lateral plasma membrane 2 CDH1, CTNNB1
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 PPARG
neuron projection 1 PTGS2
chromatin 2 NFE2L2, PPARG
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
cell periphery 1 CTNNB1
cytoskeleton 1 NOS3
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Golgi apparatus, trans-Golgi network 1 CDH1
spindle pole 2 CTNNB1, MAPK14
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
Endomembrane system 1 CTNNB1
endosome lumen 1 INS
tertiary granule membrane 1 GAA
Melanosome 1 TYR
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
euchromatin 1 CTNNB1
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle membrane 1 NOS3
transport vesicle 1 INS
azurophil granule membrane 1 GAA
beta-catenin-TCF complex 1 CTNNB1
anaphase-promoting complex 1 CDH1
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
presynaptic active zone cytoplasmic component 1 CTNNB1
[Isoform 2]: Nucleus 1 CDH1
protein-DNA complex 2 CTNNB1, NFE2L2
ficolin-1-rich granule membrane 1 GAA
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
apical junction complex 1 CDH1
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
catenin complex 2 CDH1, CTNNB1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Paula Henarejos-Escudero, Berenice Guadarrama-Flores, Francisco García-Carmona, Fernando Gandía-Herrero. Digestive glands extraction and precise pigment analysis support the exclusion of the carnivorous plant Dionaea muscipula Ellis from the Caryophyllales order. Plant science : an international journal of experimental plant biology. 2018 Sep; 274(?):342-348. doi: 10.1016/j.plantsci.2018.06.013. [PMID: 30080622]
  • Aimee N Winter, Erika K Ross, Sonia Khatter, Keith Miller, Daniel A Linseman. Chemical basis for the disparate neuroprotective effects of the anthocyanins, callistephin and kuromanin, against nitrosative stress. Free radical biology & medicine. 2017 02; 103(?):23-34. doi: 10.1016/j.freeradbiomed.2016.12.012. [PMID: 27986528]
  • Nan Song, Ling Zhang, Wei Chen, Hua Zhu, Wei Deng, Yunlin Han, Jianguo Guo, Chuan Qin. Cyanidin 3-O-β-glucopyranoside activates peroxisome proliferator-activated receptor-γ and alleviates cognitive impairment in the APP(swe)/PS1(ΔE9) mouse model. Biochimica et biophysica acta. 2016 09; 1862(9):1786-800. doi: 10.1016/j.bbadis.2016.05.016. [PMID: 27240542]
  • Andreja Vanzo, Urska Vrhovsek, Federica Tramer, Fulvio Mattivi, Sabina Passamonti. Exceptionally fast uptake and metabolism of cyanidin 3-glucoside by rat kidneys and liver. Journal of natural products. 2011 May; 74(5):1049-54. doi: 10.1021/np100948a. [PMID: 21510696]
  • Ryoji Takahashi, Joseph G Dubouzet, Hisakazu Matsumura, Kentaro Yasuda, Tsukasa Iwashina. A new allele of flower color gene W1 encoding flavonoid 3'5'-hydroxylase is responsible for light purple flowers in wild soybean Glycine soja. BMC plant biology. 2010 Jul; 10(?):155. doi: 10.1186/1471-2229-10-155. [PMID: 20663233]
  • Andrea Tarozzi, Fabiana Morroni, Adriana Merlicco, Cecilia Bolondi, Gabriella Teti, Mirella Falconi, Giorgio Cantelli-Forti, Patrizia Hrelia. Neuroprotective effects of cyanidin 3-O-glucopyranoside on amyloid beta (25-35) oligomer-induced toxicity. Neuroscience letters. 2010 Apr; 473(2):72-6. doi: 10.1016/j.neulet.2010.02.006. [PMID: 20152881]
  • Juliana Barrios, Claudia Patricia Cordero, Fabio Aristizabal, Francisco José Heredia, Alicia Lucía Morales, Coralia Osorio. Chemical analysis and screening as anticancer agent of anthocyanin-rich extract from Uva Caimarona ( Pourouma cecropiifolia Mart.) fruit. Journal of agricultural and food chemistry. 2010 Feb; 58(4):2100-10. doi: 10.1021/jf9041497. [PMID: 20121190]
  • Eun-Kyung Kwon, Dae-Young Lee, Hyungjae Lee, Dae-Ok Kim, Nam-In Baek, Young-Eon Kim, Hae-Yeong Kim. Flavonoids from the buds of Rosa damascena inhibit the activity of 3-hydroxy-3-methylglutaryl-coenzyme a reductase and angiotensin I-converting enzyme. Journal of agricultural and food chemistry. 2010 Jan; 58(2):882-6. doi: 10.1021/jf903515f. [PMID: 20038104]
  • Wei Song, Han-Jing Wang, Peter Bucheli, Pei-Fang Zhang, Dong-Zhi Wei, Yan-Hua Lu. Phytochemical profiles of different mulberry (Morus sp.) species from China. Journal of agricultural and food chemistry. 2009 Oct; 57(19):9133-40. doi: 10.1021/jf9022228. [PMID: 19761189]
  • W Ray Edwards, Judy A Hall, Alan R Rowlan, Tama Schneider-Barfield, Tzeli Julia Sun, Mohini A Patil, Margaret L Pierce, R Gary Fulcher, Alois A Bell, Margaret Essenberg. Light filtering by epidermal flavonoids during the resistant response of cotton to Xanthomonas protects leaf tissue from light-dependent phytoalexin toxicity. Phytochemistry. 2008 Sep; 69(12):2320-8. doi: 10.1016/j.phytochem.2008.05.021. [PMID: 18617197]
  • Marcella Renis, Laura Calandra, Christian Scifo, Barbara Tomasello, Venera Cardile, Luca Vanella, Roberto Bei, Luca La Fauci, Fabio Galvano. Response of cell cycle/stress-related protein expression and DNA damage upon treatment of CaCo2 cells with anthocyanins. The British journal of nutrition. 2008 Jul; 100(1):27-35. doi: 10.1017/s0007114507876239. [PMID: 18053307]
  • Tong Ho Kang, Jin Young Hur, Hyun Bok Kim, Jong Hoon Ryu, Sun Yeou Kim. Neuroprotective effects of the cyanidin-3-O-beta-d-glucopyranoside isolated from mulberry fruit against cerebral ischemia. Neuroscience letters. 2006 Jan; 391(3):122-6. doi: 10.1016/j.neulet.2005.08.053. [PMID: 16181734]
  • Min Xia, Mengjun Hou, Huilian Zhu, Jing Ma, Zhihong Tang, Qing Wang, Yan Li, Dongsheng Chi, Xiaoping Yu, Ting Zhao, Pinghua Han, Xiaodong Xia, Wenhua Ling. Anthocyanins induce cholesterol efflux from mouse peritoneal macrophages: the role of the peroxisome proliferator-activated receptor {gamma}-liver X receptor {alpha}-ABCA1 pathway. The Journal of biological chemistry. 2005 Nov; 280(44):36792-801. doi: 10.1074/jbc.m505047200. [PMID: 16107338]
  • José Cheel, Cristina Theoduloz, Jaime Rodríguez, Guillermo Saud, Peter D S Caligari, Guillermo Schmeda-Hirschmann. E-cinnamic acid derivatives and phenolics from Chilean strawberry fruits, Fragaria chiloensis ssp. chiloensis. Journal of agricultural and food chemistry. 2005 Nov; 53(22):8512-8. doi: 10.1021/jf051294g. [PMID: 16248546]
  • Takashi Ichiyanagi, Yasuo Shida, M Mamunur Rahman, Yoshihiko Hatano, Tetsuya Konishi. Extended glucuronidation is another major path of cyanidin 3-O-beta-D-glucopyranoside metabolism in rats. Journal of agricultural and food chemistry. 2005 Sep; 53(18):7312-9. doi: 10.1021/jf051002b. [PMID: 16131148]
  • Takashi Ichiyanagi, Yasuo Shida, M Mamunur Rahman, Yoshihiko Hatano, Hitoshi Matsumoto, Masao Hirayama, Tetsuya Konishi. Metabolic pathway of cyanidin 3-O-beta-D-glucopyranoside in rats. Journal of agricultural and food chemistry. 2005 Jan; 53(1):145-50. doi: 10.1021/jf0485943. [PMID: 15631521]
  • Annalucia Serafino, Paola Sinibaldi-Vallebona, Giuseppe Lazzarino, Barbara Tavazzi, Guido Rasi, Pasquale Pierimarchi, Federica Andreola, Gabriella Moroni, Giacomo Galvano, Fabio Galvano, Enrico Garaci. Differentiation of human melanoma cells induced by cyanidin-3-O-beta-glucopyranoside. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2004 Dec; 18(15):1940-2. doi: 10.1096/fj.04-1925fje. [PMID: 15451888]
  • Mi-Yeon Kim, Kunihisa Iwai, Akio Onodera, Hajime Matsue. Identification and antiradical properties of anthocyanins in fruits of Viburnum dilatatum thunb. Journal of agricultural and food chemistry. 2003 Oct; 51(21):6173-7. doi: 10.1021/jf034647p. [PMID: 14518940]
  • Angela Maria Amorini, Giuseppe Lazzarino, Fabio Galvano, Giovanna Fazzina, Barbara Tavazzi, Giacomo Galvano. Cyanidin-3-O-beta-glucopyranoside protects myocardium and erythrocytes from oxygen radical-mediated damages. Free radical research. 2003 Apr; 37(4):453-60. doi: 10.1080/1071576021000055253. [PMID: 12747740]
  • A M Amorini, G Fazzina, G Lazzarino, B Tavazzi, D Di Pierro, R Santucci, F Sinibaldi, F Galvano, G Galvano. Activity and mechanism of the antioxidant properties of cyanidin-3-O-beta-glucopyranoside. Free radical research. 2001 Dec; 35(6):953-66. doi: 10.1080/10715760100301451. [PMID: 11811546]
  • Y M Knox, K Hayashi, T Suzutani, M Ogasawara, I Yoshida, R Shiina, A Tsukui, N Terahara, M Azuma. Activity of anthocyanins from fruit extract of Ribes nigrum L. against influenza A and B viruses. Acta virologica. 2001; 45(4):209-15. doi: ". [PMID: 11885927]