L-Serine (BioDeep_00000001374)

 

Secondary id: BioDeep_00000398118

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


(2S)-2-amino-3-hydroxypropanoic acid

化学式: C3H7NO3 (105.0425912)
中文名称: L-丝氨酸, 丝氨酸
谱图信息: 最多检出来源 Homo sapiens(feces) 0.2%

Reviewed

Last reviewed on 2024-07-01.

Cite this Page

L-Serine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/l-serine (retrieved 2024-11-22) (BioDeep RN: BioDeep_00000001374). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(C(=O)O)N)O
InChI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)

描述信息

Serine (Ser) or L-serine is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (–NH2) and carboxyl (–COOH) functional groups, along with a side chain (R group) specific to each amino acid. L-serine is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Serine is found in all organisms ranging from bacteria to plants to animals. It is classified as a polar, uncharged (at physiological pH), aliphatic amino acid. In humans, serine is a nonessential amino acid that can be easily derived from glycine. A non-essential amino acid is an amino acid that can be synthesized from central metabolic pathway intermediates in humans and is not required in the diet. Like all the amino acid building blocks of protein and peptides, serine can become essential under certain conditions, and is thus important in maintaining health and preventing disease. L-Serine may be derived from four possible sources: dietary intake; biosynthesis from the glycolytic intermediate 3-phosphoglycerate; from glycine; and by protein and phospholipid degradation. Little data is available on the relative contributions of each of these four sources of l-serine to serine homoeostasis. It is very likely that the predominant source of l-serine will be very different in different tissues and during different stages of human development. In the biosynthetic pathway, the glycolytic intermediate 3-phosphoglycerate is converted into phosphohydroxypyruvate, in a reaction catalyzed by 3-phosphoglycerate dehydrogenase (3- PGDH; EC 1.1.1.95). Phosphohydroxypyruvate is metabolized to phosphoserine by phosphohydroxypyruvate aminotransferase (EC 2.6.1.52) and, finally, phosphoserine is converted into l-serine by phosphoserine phosphatase (PSP; EC 3.1.3.3). In liver tissue, the serine biosynthetic pathway is regulated in response to dietary and hormonal changes. Of the three synthetic enzymes, the properties of 3-PGDH and PSP are the best documented. Hormonal factors such as glucagon and corticosteroids also influence 3-PGDH and PSP activities in interactions dependent upon the diet. L-serine is the predominant source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. It has long been recognized that, in cell cultures, L-serine is a conditional essential amino acid, because it cannot be synthesized in sufficient quantities to meet the cellular demands for its utilization. In recent years, L-serine and the products of its metabolism have been recognized not only to be essential for cell proliferation, but also to be necessary for specific functions in the central nervous system. The findings of altered levels of serine and glycine in patients with psychiatric disorders and the severe neurological abnormalities in patients with defects of L-serine synthesis underscore the importance of L-serine in brain development and function. (PMID 12534373).
[Spectral] L-Serine (exact mass = 105.04259) and D-2-Aminobutyrate (exact mass = 103.06333) and 4-Aminobutanoate (exact mass = 103.06333) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
Dietary supplement. L-Serine is found in many foods, some of which are cold cut, mammee apple, coho salmon, and carrot.

L-Serine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=56-45-1 (retrieved 2024-07-01) (CAS RN: 56-45-1). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.

同义名列表

49 个代谢物同义名

(3R,3R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3-DIOL; (3R,3r,6S)-4,5-DIDEHYDRO-5,6-dihydro-b,b-carotene-3,3-diol; (3R,3r,6S)-4,5-DIDEHYDRO-5,6-dihydro-β,β-carotene-3,3-diol; (S)-alpha-Amino-beta-hydroxypropionic acid; (S)-beta-Amino-3-hydroxypropionic acid; (S)-alpha-Amino-beta-hydroxypropionate; (S)-2-Amino-3-hydroxy-propanoic acid; (2S)-2-Amino-3-hydroxypropanoic acid; (S)-2-Amino-3-hydroxypropanoic acid; (S)-b-Amino-3-hydroxypropionic acid; (S)-a-Amino-b-hydroxypropionic acid; (S)-Α-amino-β-hydroxypropionic acid; (S)-beta-Amino-3-hydroxypropionate; L-3-Hydroxy-2-aminopropionic acid; L-2-Amino-3-hydroxypropionic acid; (S)-2-Amino-3-hydroxy-propanoate; (2S)-2-Amino-3-hydroxypropanoate; (S)-b-Amino-3-hydroxypropionate; 2-Amino-3-hydroxypropanoic acid; (S)-2-Amino-3-hydroxypropanoate; (S)-Α-amino-β-hydroxypropionate; (S)-a-Amino-b-hydroxypropionate; L-3-Hydroxy-2-aminopropionate; L-2-Amino-3-hydroxypropionate; 2-Amino-3-hydroxypropanoate; beta-Hydroxy-L-alanine; beta-Hydroxyalanine; b-Hydroxy-L-alanine; Β-hydroxy-L-alanine; L-3-Hydroxy-alanine; 3-Hydroxy-L-alanine; b-Hydroxyalanine; Β-hydroxyalanine; (S)-(-)-Serine; L-(-)-Serine; XANTHOPHYLL; (-)-Serine; (S)-Serine; L-Serine; L Serine; L-Serin; e 161b; SERINE; Bo-Xan; L-Ser; Ser; S; Serine; L-Serine



数据库引用编号

51 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

2736 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(8)

WikiPathways(2)

Plant Reactome(118)

  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide
  • Metabolism and regulation: CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide
  • PCO cycle: Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide

INOH(6)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2602)

PharmGKB(0)

430 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yasmim Isabel Retore, Fabíola Lucini, Rafael Cardoso Rial, Claudia Andrea Lima Cardoso, Pedro Filho Noronha Souza, Simone Simionatto, Luana Rossato. Antifungal activity of Caryocar brasiliense camb. Alone or along with antifungal agents against multidrug-resistant Candida auris. Journal of ethnopharmacology. 2024 Aug; 330(?):118240. doi: 10.1016/j.jep.2024.118240. [PMID: 38677574]
  • Katarzyna Dettlaff, Gabriela Anglart, Agnieszka Gruszczyńska, Anna Jelińska. Compatibility studies of selected multichamber bag parenteral nutrition with fluconazole. Nutrition (Burbank, Los Angeles County, Calif.). 2024 Jul; 123(?):112417. doi: 10.1016/j.nut.2024.112417. [PMID: 38593672]
  • Xiaomei He, Tingting Lin, Yuying Xie, Jinjing Li, Yuanyuan Ge, Shuncheng Zhang, Jun Fan. Backbone cyclization of Salmonella typhimurium diaminopropionate ammonia-lyase to enhance the activity and stability. Protein expression and purification. 2024 Jun; 218(?):106447. doi: 10.1016/j.pep.2024.106447. [PMID: 38369031]
  • Tyler M Guido, Samuel D Ratcliffe, Amanda Rahmlow, Matthew A Zambrello, Anthony A Provates, Robert B Clark, Michael B Smith, Frank C Nichols. Metabolism of serine/glycine lipids by human gingival cells in culture. Molecular oral microbiology. 2024 Jun; 39(3):103-112. doi: 10.1111/omi.12439. [PMID: 37850509]
  • Zahra Saeidi, Rashin Giti, Azadeh Emami, Mehdi Rostami, Farhad Mohammadi. Thermosensitive and mucoadhesive gels containing solid lipid nanoparticles loaded with fluconazole and niosomes loaded with clindamycin for the treatment of periodontal diseases: a laboratory experiment. BMC oral health. 2024 May; 24(1):551. doi: 10.1186/s12903-024-04322-6. [PMID: 38734599]
  • Xin-Yu Cao, Xinge Li, Feng Wang, Yichen Duan, Xingmei Wu, Guo-Qiang Lin, Meiyu Geng, Min Huang, Ping Tian, Shuai Tang, Dingding Gao. Identification of benzo[b]thiophene-1,1-dioxide derivatives as novel PHGDH covalent inhibitors. Bioorganic chemistry. 2024 May; 146(?):107330. doi: 10.1016/j.bioorg.2024.107330. [PMID: 38579615]
  • Sicong Ma, Roger Sandhoff, Xiu Luo, Fuwei Shang, Qiaozhen Shi, Zhaolong Li, Jingxia Wu, Yanan Ming, Frank Schwarz, Alaa Madi, Nina Weisshaar, Alessa Mieg, Marvin Hering, Ferdinand Zettl, Xin Yan, Kerstin Mohr, Nora Ten Bosch, Zhe Li, Gernot Poschet, Hans-Reimer Rodewald, Nina Papavasiliou, Xi Wang, Pu Gao, Guoliang Cui. Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos. Science immunology. 2024 Apr; 9(94):eadg8817. doi: 10.1126/sciimmunol.adg8817. [PMID: 38640251]
  • Anastasiia Delova, Andreea Pasc, Antonio Monari. Interaction of the Immune System TIM-3 Protein with a Model Cellular Membrane Containing Phosphatidyl-Serine Lipids. Chemistry (Weinheim an der Bergstrasse, Germany). 2024 Apr; 30(22):e202304318. doi: 10.1002/chem.202304318. [PMID: 38345892]
  • Xiaohu Yang, Wenchao Yang, Shuang He, He Ye, Shanshan Lei. Danhong formula alleviates endothelial dysfunction and reduces blood pressure in hypertension by regulating MicroRNA 24 - Phosphatidylinositol 3-Kinase-Serine/Threonine Kinase- Endothelial Nitric Oxide Synthase axis. Journal of ethnopharmacology. 2024 Apr; 323(?):117615. doi: 10.1016/j.jep.2023.117615. [PMID: 38163560]
  • Maria Alicia Rueda Huélamo, Alba Martínez Perlado, Valeria Consoli, Aurora García-Tejedor, Claudia Monika Haros, José Moisés Laparra Llopis. Improvement of hepatic innate immunity in chemically-injured livers to develop hepatocarcinoma by a serine type-protease inhibitors enriched extract from Chenopodium quinoa. Food & function. 2024 Apr; 15(7):3600-3614. doi: 10.1039/d3fo03083k. [PMID: 38469889]
  • Chun Chu, Shengquan Liu, Liangui Nie, Hongming Hu, Yi Liu, Jun Yang. The interactions and biological pathways among metabolomics products of patients with coronary heart disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116305. doi: 10.1016/j.biopha.2024.116305. [PMID: 38422653]
  • Qiushi Chen, Ya Li, Tianjiao Shen, Rong Wang, Meiling Su, Qiong Luo, Hua Shi, Guodong Lu, Zonghua Wang, Kevin G Hardwick, Mo Wang. Phosphorylation of Mad1 at serine 18 by Mps1 is required for the full virulence of rice blast fungus, Magnaporthe oryzae. Molecular plant pathology. 2024 Apr; 25(4):e13456. doi: 10.1111/mpp.13456. [PMID: 38619864]
  • Hanna Stieber, Lara Junghanns, Hannah Wilhelm, Maria Batliner, Alexander Maximilian Aldejohann, Oliver Kurzai, Ronny Martin. The sphingolipid inhibitor myriocin increases Candida auris susceptibility to amphotericin B. Mycoses. 2024 Apr; 67(4):e13723. doi: 10.1111/myc.13723. [PMID: 38551121]
  • Jiaci Li, Xinping Wei, Yuchen Sun, Xiaofang Chen, Ying Zhang, Xiaoyu Cui, Jianbo Shu, Dong Li, Chunquan Cai. Phosphoserine aminotransferase deficiency diagnosed by whole-exome sequencing and LC-MS/MS reanalysis: A case report and review of literature. Molecular genetics & genomic medicine. 2024 Apr; 12(4):e2400. doi: 10.1002/mgg3.2400. [PMID: 38546032]
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  • Angelo Spinello, Luisa D'Anna, Emmanuelle Bignon, Tom Miclot, Stéphanie Grandemange, Alessio Terenzi, Giampaolo Barone, Florent Barbault, Antonio Monari. Mechanism of the Covalent Inhibition of Human Transmembrane Protease Serine 2 as an Original Antiviral Strategy. The journal of physical chemistry. B. 2023 07; 127(28):6287-6295. doi: 10.1021/acs.jpcb.3c02910. [PMID: 37428676]
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