SERINE (BioDeep_00000398118)
Main id: BioDeep_00000001374
natural product PANOMIX_OTCML-2023
代谢物信息卡片
L-Serine
化学式: C3H7NO3 (105.0425912)
中文名称: L-丝氨酸
谱图信息:
最多检出来源 Homo sapiens(blood) 0.27%
分子结构信息
SMILES: C(C(C(=O)O)N)O
InChI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)
描述信息
An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Acquisition and generation of the data is financially supported by the Max-Planck-Society
L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
同义名列表
数据库引用编号
66 个数据库交叉引用编号
- ChEBI: CHEBI:17822
- ChEBI: CHEBI:17115
- KEGG: C00065
- KEGGdrug: D00016
- PubChem: 5951
- DrugBank: DB00133
- ChEMBL: CHEMBL11298
- MeSH: Serine
- CAS: 6898-95-9
- CAS: 56-45-1
- MoNA: CCMSLIB00000479736
- MoNA: CCMSLIB00005463917
- MoNA: CCMSLIB00005720603
- MoNA: MoNA038558
- MoNA: MoNA038492
- MoNA: MoNA037886
- MoNA: MoNA037170
- MoNA: MoNA037068
- MoNA: MoNA036511
- MoNA: MoNA036510
- MoNA: MoNA036509
- MoNA: MoNA036043
- MoNA: MoNA036042
- MoNA: MoNA036040
- MoNA: MoNA034063
- MoNA: MoNA034062
- MoNA: MoNA034060
- MoNA: MoNA033743
- MoNA: MoNA033741
- MoNA: MoNA033740
- MoNA: MoNA032107
- MoNA: MoNA032106
- MoNA: MoNA032105
- MoNA: MoNA024364
- MoNA: MoNA024322
- MoNA: MoNA001793
- MoNA: MoNA001792
- MoNA: MoNA001791
- MoNA: FiehnHILIC002984
- MoNA: FiehnHILIC002325
- MoNA: FiehnHILIC001510
- MoNA: FiehnHILIC000761
- MoNA: CCMSLIB00003740035
- MoNA: CE000504
- MoNA: CE000503
- MoNA: CE000502
- MoNA: CE000501
- MoNA: CE000500
- MoNA: CE000499
- MoNA: CE000498
- MoNA: CE000497
- MoNA: CE000496
- MoNA: CE000495
- MoNA: CE000494
- MoNA: CE000493
- MoNA: CE000492
- MoNA: CE000491
- MoNA: CE000490
- MetaboLights: MTBLC17822
- PubChem: 3365
- KNApSAcK: C00001393
- PDB-CCD: SER
- 3DMET: B01145
- NIKKAJI: J1.195I
- RefMet: Serine
- medchemexpress: HY-N0650
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tyler M Guido, Samuel D Ratcliffe, Amanda Rahmlow, Matthew A Zambrello, Anthony A Provates, Robert B Clark, Michael B Smith, Frank C Nichols. Metabolism of serine/glycine lipids by human gingival cells in culture.
Molecular oral microbiology.
2024 Jun; 39(3):103-112. doi:
10.1111/omi.12439. [PMID: 37850509] - Xiaomei He, Tingting Lin, Yuying Xie, Jinjing Li, Yuanyuan Ge, Shuncheng Zhang, Jun Fan. Backbone cyclization of Salmonella typhimurium diaminopropionate ammonia-lyase to enhance the activity and stability.
Protein expression and purification.
2024 Jun; 218(?):106447. doi:
10.1016/j.pep.2024.106447. [PMID: 38369031] - Xin-Yu Cao, Xinge Li, Feng Wang, Yichen Duan, Xingmei Wu, Guo-Qiang Lin, Meiyu Geng, Min Huang, Ping Tian, Shuai Tang, Dingding Gao. Identification of benzo[b]thiophene-1,1-dioxide derivatives as novel PHGDH covalent inhibitors.
Bioorganic chemistry.
2024 May; 146(?):107330. doi:
10.1016/j.bioorg.2024.107330. [PMID: 38579615] - Sicong Ma, Roger Sandhoff, Xiu Luo, Fuwei Shang, Qiaozhen Shi, Zhaolong Li, Jingxia Wu, Yanan Ming, Frank Schwarz, Alaa Madi, Nina Weisshaar, Alessa Mieg, Marvin Hering, Ferdinand Zettl, Xin Yan, Kerstin Mohr, Nora Ten Bosch, Zhe Li, Gernot Poschet, Hans-Reimer Rodewald, Nina Papavasiliou, Xi Wang, Pu Gao, Guoliang Cui. Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos.
Science immunology.
2024 Apr; 9(94):eadg8817. doi:
10.1126/sciimmunol.adg8817. [PMID: 38640251] - Anastasiia Delova, Andreea Pasc, Antonio Monari. Interaction of the Immune System TIM-3 Protein with a Model Cellular Membrane Containing Phosphatidyl-Serine Lipids.
Chemistry (Weinheim an der Bergstrasse, Germany).
2024 Apr; 30(22):e202304318. doi:
10.1002/chem.202304318. [PMID: 38345892] - Xiaohu Yang, Wenchao Yang, Shuang He, He Ye, Shanshan Lei. Danhong formula alleviates endothelial dysfunction and reduces blood pressure in hypertension by regulating MicroRNA 24 - Phosphatidylinositol 3-Kinase-Serine/Threonine Kinase- Endothelial Nitric Oxide Synthase axis.
Journal of ethnopharmacology.
2024 Apr; 323(?):117615. doi:
10.1016/j.jep.2023.117615. [PMID: 38163560] - Maria Alicia Rueda Huélamo, Alba Martínez Perlado, Valeria Consoli, Aurora García-Tejedor, Claudia Monika Haros, José Moisés Laparra Llopis. Improvement of hepatic innate immunity in chemically-injured livers to develop hepatocarcinoma by a serine type-protease inhibitors enriched extract from Chenopodium quinoa.
Food & function.
2024 Apr; 15(7):3600-3614. doi:
10.1039/d3fo03083k. [PMID: 38469889] - Jiaci Li, Xinping Wei, Yuchen Sun, Xiaofang Chen, Ying Zhang, Xiaoyu Cui, Jianbo Shu, Dong Li, Chunquan Cai. Phosphoserine aminotransferase deficiency diagnosed by whole-exome sequencing and LC-MS/MS reanalysis: A case report and review of literature.
Molecular genetics & genomic medicine.
2024 Apr; 12(4):e2400. doi:
10.1002/mgg3.2400. [PMID: 38546032] - Chun Chu, Shengquan Liu, Liangui Nie, Hongming Hu, Yi Liu, Jun Yang. The interactions and biological pathways among metabolomics products of patients with coronary heart disease.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Apr; 173(?):116305. doi:
10.1016/j.biopha.2024.116305. [PMID: 38422653] - Qiushi Chen, Ya Li, Tianjiao Shen, Rong Wang, Meiling Su, Qiong Luo, Hua Shi, Guodong Lu, Zonghua Wang, Kevin G Hardwick, Mo Wang. Phosphorylation of Mad1 at serine 18 by Mps1 is required for the full virulence of rice blast fungus, Magnaporthe oryzae.
Molecular plant pathology.
2024 Apr; 25(4):e13456. doi:
10.1111/mpp.13456. [PMID: 38619864] - Xiaojing Liu, Weijia Cheng, Peng Yao, Kexin Ren, Yu Wang, Yingnan Sun, Xin Hou, Li Lu, Xiangsong Chen. Conserved serine phosphorylation regulates histone deacetylase activity in Arabidopsis and humans.
Plant physiology.
2024 Mar; 194(4):2017-2021. doi:
10.1093/plphys/kiad587. [PMID: 37966963] - Jason L J Lin, Hanna S Yuan. Lipid-Binding Regions within PKC-Related Serine/Threonine Protein Kinase N1 (PKN1) Required for Its Regulation.
Biochemistry.
2024 Mar; 63(6):743-753. doi:
10.1021/acs.biochem.4c00009. [PMID: 38441874] - Katarina Jojić, Fabio Gherlone, Zoltán Cseresnyés, Alexander U Bissell, Sandra Hoefgen, Stefan Hoffmann, Ying Huang, Slavica Janevska, Marc Thilo Figge, Vito Valiante. The spatial organization of sphingofungin biosynthesis in Aspergillus fumigatus and its cross-interaction with sphingolipid metabolism.
mBio.
2024 Mar; 15(3):e0019524. doi:
10.1128/mbio.00195-24. [PMID: 38380921] - Mei Guo, Yanshuang Zhuang, Yang Wu, Chun Zhang, Xudong Cheng, Dong Xu, Zili Zhang. The cell fate regulator DACH1 modulates ferroptosis through affecting P53/SLC25A37 signaling in fibrotic disease.
Hepatology communications.
2024 Mar; 8(3):. doi:
10.1097/hc9.0000000000000396. [PMID: 38437058] - Min Qiu, Yaru Sun, Siqun Tu, Huaibo Li, Xin Yang, Haiyang Zhao, Maozhu Yin, Yaning Li, Wenwu Ye, Ming Wang, Yuanchao Wang. Mining oomycete proteomes for phosphatome leads to the identification of specific expanded phosphatases in oomycetes.
Molecular plant pathology.
2024 Mar; 25(3):e13425. doi:
10.1111/mpp.13425. [PMID: 38462784] - Linsong Wang, Chenglei Qin, Qunqun Guo, Yi Han, Guicai Du, Ronggui Li. Transcriptome Study of Bursaphelenchus xylophilus Treated with Fomepizole Reveals a Serine/Threonine-Protein Phosphatase Gene that Is Substantially Linked with Vitality and Pathogenicity.
Phytopathology.
2024 Mar; 114(3):630-640. doi:
10.1094/phyto-04-23-0113-r. [PMID: 38457135] - Lianghong Yin, Dandan Xi, Yuefeng Shen, Nana Ding, Qingsong Shao, Yongchang Qian, Yu Fang. Rewiring Metabolic Flux in Corynebacterium glutamicum Using a CRISPR/dCpf1-Based Bifunctional Regulation System.
Journal of agricultural and food chemistry.
2024 Feb; 72(6):3077-3087. doi:
10.1021/acs.jafc.3c08529. [PMID: 38303604] - Wei Liu, Giovanni Giuriani, Anezka Havlikova, Dezhi Li, Douglas J Lamont, Susanne Neugart, Christos N Velanis, Jan Petersen, Ute Hoecker, John M Christie, Gareth I Jenkins. Phosphorylation of Arabidopsis UVR8 photoreceptor modulates protein interactions and responses to UV-B radiation.
Nature communications.
2024 Feb; 15(1):1221. doi:
10.1038/s41467-024-45575-7. [PMID: 38336824] - Christopher W Benson, Matthew R Sheltra, David R Huff. The genome of Salmacisia buchloëana, the parasitic puppet master pulling strings of sexual phenotypic monstrosities in buffalograss.
G3 (Bethesda, Md.).
2024 02; 14(2):. doi:
10.1093/g3journal/jkad238. [PMID: 37847611] - Qianlu Yang, Sisi Deng, Heike Preibsch, Tim-Colin Schade, André Koch, Georgy Berezhnoy, Laimdota Zizmare, Anna Fischer, Brigitte Gückel, Annette Staebler, Andreas D Hartkopf, Bernd J Pichler, Christian la Fougère, Markus Hahn, Irina Bonzheim, Konstantin Nikolaou, Christoph Trautwein. Image-guided metabolomics and transcriptomics reveal tumour heterogeneity in luminal A and B human breast cancer beyond glucose tracer uptake.
Clinical and translational medicine.
2024 02; 14(2):e1550. doi:
10.1002/ctm2.1550. [PMID: 38332687] - Hélène Sanfaçon, Tim Skern. AlphaFold modeling of nepovirus 3C-like proteinases provides new insights into their diverse substrate specificities.
Virology.
2024 02; 590(?):109956. doi:
10.1016/j.virol.2023.109956. [PMID: 38052140] - Chuanling Li, Xuetong Li, Zhiping Deng, Yuning Song, Xinye Liu, Xiaohan Alex Tang, Ziye Li, Ya Zhang, Baowen Zhang, Wenqiang Tang, Jian-Xiu Shang, Yu Sun. EGR1 and EGR2 positively regulate plant ABA signaling by modulating the phosphorylation of SnRK2.2.
The New phytologist.
2024 Feb; 241(4):1492-1509. doi:
10.1111/nph.19458. [PMID: 38095247] - Lucas Frungillo. Serine biosynthetic pathways signal to diverse outputs in plants.
The Plant cell.
2024 Jan; 36(2):221-222. doi:
10.1093/plcell/koad272. [PMID: 37877455] - Mengyao Wang, Hiromitsu Tabeta, Kinuka Ohtaka, Ayuko Kuwahara, Ryuichi Nishihama, Toshiki Ishikawa, Kiminori Toyooka, Mayuko Sato, Mayumi Wakazaki, Hiromichi Akashi, Hiroshi Tsugawa, Tsubasa Shoji, Yozo Okazaki, Keisuke Yoshida, Ryoichi Sato, Ali Ferjani, Takayuki Kohchi, Masami Yokota Hirai. The phosphorylated pathway of serine biosynthesis affects sperm, embryo, and sporophyte development, and metabolism in Marchantia polymorpha.
Communications biology.
2024 01; 7(1):102. doi:
10.1038/s42003-023-05746-6. [PMID: 38267515] - Yuhao Ma, Ganxian Cai, Jianfei Chen, Xue Yang, Guoying Hua, Deping Han, Xinhai Li, Dengzhen Feng, Xuemei Deng. Combined transcriptome and metabolome analysis reveals breed-specific regulatory mechanisms in Dorper and Tan sheep.
BMC genomics.
2024 Jan; 25(1):70. doi:
10.1186/s12864-023-09870-9. [PMID: 38233814] - Marco A de Oliveira, Lilian H Florentino, Thais T Sales, Rayane N Lima, Luciana R C Barros, Cintia G Limia, Mariana S M Almeida, Maria L Robledo, Leila M G Barros, Eduardo O Melo, Daniela M Bittencourt, Stevens K Rehen, Martín H Bonamino, Elibio Rech. Protocol for the establishment of a serine integrase-based platform for functional validation of genetic switch controllers in eukaryotic cells.
PloS one.
2024; 19(5):e0303999. doi:
10.1371/journal.pone.0303999. [PMID: 38781126] - Viswanada R Bysani, Ayesha S Alam, Arren Bar-Even, Fabian Machens. Engineering and evolution of the complete Reductive Glycine Pathway in Saccharomyces cerevisiae for formate and CO2 assimilation.
Metabolic engineering.
2024 Jan; 81(?):167-181. doi:
10.1016/j.ymben.2023.11.007. [PMID: 38040111] - Sakari Mäntyselkä, Kalle Kolari, Philipp Baumert, Laura Ylä-Outinen, Lauri Kuikka, Suvi Lahtonen, Perttu Permi, Henning Wackerhage, Elina Kalenius, Riikka Kivelä, Juha J Hulmi. Serine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism, and mTORC1 signaling.
American journal of physiology. Endocrinology and metabolism.
2024 Jan; 326(1):E73-E91. doi:
10.1152/ajpendo.00151.2023. [PMID: 37991454] - Guilherme Nuñez Jaroque, Augusto Leonardo Dos Santos, Patrícia Sartorelli, Luciano Caseli. Unsaturation of serine lipids modulating the interaction of a cytosporone with models of the external leaflet of tumorigenic cell membranes.
Chemistry and physics of lipids.
2024 01; 258(?):105363. doi:
10.1016/j.chemphyslip.2023.105363. [PMID: 38042456] - Zhishan Cao, Jinjun Cao, Volodymyr Vlasenko, Olha Bakumenko, Weihai Li. Molecular characterization and functional analysis of a beta-1,3-glucan recognition protein from oriental fruit moth Grapholita molesta (Lepidoptera: Tortricidae).
Archives of insect biochemistry and physiology.
2024 Jan; 115(1):e22068. doi:
10.1002/arch.22068. [PMID: 38013606] - Michele Galluccio, Tiziano Mazza, Mariafrancesca Scalise, Martina Tripicchio, Martina Scarpelli, Maria Tolomeo, Lorena Pochini, Cesare Indiveri. Over-Production of the Human SLC7A10 in E. coli and Functional Assay in Proteoliposomes.
International journal of molecular sciences.
2023 Dec; 25(1):. doi:
10.3390/ijms25010536. [PMID: 38203703] - Hongyu Ji, You Wu, Xuewei Zhao, Jiang-Lin Miao, Shuwen Deng, Shixing Li, Rui Gao, Zhong-Jian Liu, Junwen Zhai. Genome-Wide Identification and Expression Analysis of WNK Kinase Gene Family in Acorus.
International journal of molecular sciences.
2023 Dec; 24(24):. doi:
10.3390/ijms242417594. [PMID: 38139421] - Younès Dellero, Solenne Berardocco, Alain Bouchereau. U-13C-glucose incorporation into source leaves of Brassica napus highlights light-dependent regulations of metabolic fluxes within central carbon metabolism.
Journal of plant physiology.
2023 Dec; 292(?):154162. doi:
10.1016/j.jplph.2023.154162. [PMID: 38103478] - Dominik Awad, Pham Hong Anh Cao, Thomas L Pulliam, Meredith Spradlin, Elavarasan Subramani, Tristen V Tellman, Caroline F Ribeiro, Riccardo Muzzioli, Brittany E Jewell, Hubert Pakula, Jeffrey J Ackroyd, Mollianne M Murray, Jenny J Han, Mei Leng, Antrix Jain, Badrajee Piyarathna, JIngjing Liu, Xingzhi Song, Jianhua Zhang, Albert R Klekers, Justin M Drake, Michael M Ittmann, Cristian Coarfa, David Piwnica-Worms, Mary C Farach-Carson, Massimo Loda, Livia S Eberlin, Daniel E Frigo. Adipose triglyceride lipase is a therapeutic target in advanced prostate cancer that promotes metabolic plasticity.
Cancer research.
2023 Dec; ?(?):. doi:
10.1158/0008-5472.can-23-0555. [PMID: 38038968] - Huanjie Yang, Xeniya Kim, Jan Skłenar, Sébastien Aubourg, Gloria Sancho-Andrés, Elia Stahl, Marie-Charlotte Guillou, Nora Gigli-Bisceglia, Loup Tran Van Canh, Kyle W Bender, Annick Stintzi, Philippe Reymond, Clara Sánchez-Rodríguez, Christa Testerink, Jean-Pierre Renou, Frank L H Menke, Andreas Schaller, Jack Rhodes, Cyril Zipfel. Subtilase-mediated biogenesis of the expanded family of SERINE RICH ENDOGENOUS PEPTIDES.
Nature plants.
2023 12; 9(12):2085-2094. doi:
10.1038/s41477-023-01583-x. [PMID: 38049516] - Alyssa R Stonebraker, Rachel Hankin, Kathryn L Kapp, Peng Li, Stephen J Valentine, Justin Legleiter. Charge within Nt17 peptides modulates huntingtin aggregation and initial lipid binding events.
Biophysical chemistry.
2023 12; 303(?):107123. doi:
10.1016/j.bpc.2023.107123. [PMID: 37852163] - Kyong-Oh Shin, Bokyung Kim, Yerim Choi, Yoo-Jin Bae, Jae-Ho Park, Soo-Hyun Park, Jin-Taek Hwang, Eung Ho Choi, Yoshikazu Uchida, Kyungho Park. Barrier abnormalities in type 1 diabetes mellitus: the roles of inflammation and ceramide metabolism.
The Journal of investigative dermatology.
2023 Nov; ?(?):. doi:
10.1016/j.jid.2023.10.010. [PMID: 37952608] - Thomas Barske, Philipp Spät, Hendrik Schubert, Peter Walke, Boris Maček, Martin Hagemann. The Role of Serine/Threonine-Specific Protein Kinases in Cyanobacteria - SpkB Is Involved in Acclimation to Fluctuating Conditions in Synechocystis sp. PCC 6803.
Molecular & cellular proteomics : MCP.
2023 Nov; 22(11):100656. doi:
10.1016/j.mcpro.2023.100656. [PMID: 37797745] - Takafumi Hashimoto, Kenji Hashimoto, Hiroki Shindo, Shoko Tsuboyama, Takuya Miyakawa, Masaru Tanokura, Kazuyuki Kuchitsu. Enhanced Ca2+ binding to EF-hands through phosphorylation of conserved serine residues activates MpRBOHB and chitin-triggered ROS production.
Physiologia plantarum.
2023 Nov; 175(6):e14101. doi:
10.1111/ppl.14101. [PMID: 38148249] - Xiaohui Wu, Ziqi Sun, Feiyan Qi, Hua Liu, Mingbo Zhao, Juan Wang, Mengmeng Wang, Ruifang Zhao, Yue Wu, Wenzhao Dong, Zheng Zheng, Xinyou Zhang. Cytological and transcriptomic analysis to unveil the mechanism of web blotch resistance in Peanut.
BMC plant biology.
2023 Oct; 23(1):518. doi:
10.1186/s12870-023-04545-9. [PMID: 37884908] - Sara Rosa-Téllez, Andrea Alcántara-Enguídanos, Federico Martínez-Seidel, Ruben Casatejada-Anchel, Sompop Saeheng, Clayton L Bailes, Alexander Erban, David Barbosa-Medeiros, Paula Alepúz, José Tomás Matus, Joachim Kopka, Jesús Muñoz-Bertomeu, Stephan Krueger, Sanja Roje, Alisdair R Fernie, Roc Ros. The serine-glycine-one carbon metabolic network orchestrates changes in nitrogen and sulfur metabolism and shapes plant development.
The Plant cell.
2023 Oct; ?(?):. doi:
10.1093/plcell/koad256. [PMID: 37804096] - João Antonio Siqueira, Youjun Zhang, Adriano Nunes-Nesi, Alisdair R Fernie, Wagner L Araújo. Beyond photorespiration: the significance of glycine and serine in leaf metabolism.
Trends in plant science.
2023 10; 28(10):1092-1094. doi:
10.1016/j.tplants.2023.06.012. [PMID: 37407411] - Chiao-Hui Hsieh, Chen-Tsung Huang, Yi-Sheng Cheng, Chun-Hua Hsu, Wen-Ming Hsu, Yun-Hsien Chung, Yen-Lin Liu, Tsai-Shan Yang, Chia-Yu Chien, Yu-Hsuan Lee, Hsuan-Cheng Huang, Hsueh-Fen Juan. Homoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Oct; 166(?):115429. doi:
10.1016/j.biopha.2023.115429. [PMID: 37673018] - Xi Meng, Guoqi Yu, Tingyu Luo, Ruiyuan Zhang, Jun Zhang, Yongjie Liu. Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat offspring.
Chemosphere.
2023 Sep; 341(?):140120. doi:
10.1016/j.chemosphere.2023.140120. [PMID: 37696479] - Robert J DiMario, Ashley N Kophs, Anthony J A Apalla, James N Schnable, Asaph B Cousins. Multiple highly expressed phosphoenolpyruvate carboxylase genes have divergent enzyme kinetic properties in two C4 grasses.
Annals of botany.
2023 Sep; ?(?):. doi:
10.1093/aob/mcad116. [PMID: 37675505] - Ching-Huey Yang, Yun-Ching Chang, Chung-Chi Hsu, Cheng-Han Lin, I-Ju Chen, Yen-Ting Wu, Yu-Yan Lan. Fucoidan Enhances Cisplatin-induced Effects on SCC-25 Human Oral Cancer Cells by Inhibiting the PI3K/AKT Pathway.
Anticancer research.
2023 Sep; 43(9):4015-4022. doi:
10.21873/anticanres.16589. [PMID: 37648299] - Jia-Xin Chen, Qi-Jun Fang, Yi-Gang Wan, Ying-Lu Liu, Yu Wang, Wei Wu, Yue Tu, Mei-Zi Wang, Dian-Guang Wang, Hai-Tao Ge. [Effects and mechanisms of total flavones of Abelmoschus manihot in inhibiting podocyte necroptosis and renal fibrosis in diabetic kidney disease].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Aug; 48(15):4137-4146. doi:
10.19540/j.cnki.cjcmm.20230417.701. [PMID: 37802782] - Su-Bin Jin, Si-Wook Jang, Ji-Ae Shin, Na-Hee Jung, Hyun-A Kim, Seo-Young Park, Woo-Cheol Lee, Kwang-Hoon Kong. Functional significance of serine 13 in the active site of glutathione S-transferase F3 from Oryza sativa.
Pesticide biochemistry and physiology.
2023 Aug; 194(?):105463. doi:
10.1016/j.pestbp.2023.105463. [PMID: 37532308] - Angelo Spinello, Luisa D'Anna, Emmanuelle Bignon, Tom Miclot, Stéphanie Grandemange, Alessio Terenzi, Giampaolo Barone, Florent Barbault, Antonio Monari. Mechanism of the Covalent Inhibition of Human Transmembrane Protease Serine 2 as an Original Antiviral Strategy.
The journal of physical chemistry. B.
2023 07; 127(28):6287-6295. doi:
10.1021/acs.jpcb.3c02910. [PMID: 37428676] - Zhicheng Huang, Huijuan Cao, Huan Wang, Pengyun Huang, Jing Wang, Ying-Ying Cai, Qing Wang, Yan Li, Jiaoyu Wang, Xiao-Hong Liu, Fu-Cheng Lin, Jianping Lu. The triglyceride catabolism regulated by a serine/threonine protein phosphatase, Smek1, is required for development and plant infection in Magnaporthe oryzae.
Molecular plant pathology.
2023 Jun; ?(?):. doi:
10.1111/mpp.13368. [PMID: 37357820] - Xiao-Di Zhai, Su-Yun Zhang, Dong Chen, Wei-Jun Li, Jin-Jun Wang, Dong Wei. Comparative multi-tissue analyses identify testis-specific serine/threonine protein kinase (TSSK) genes involved in male fertility in the melon fly Zeugodacus cucurbitae.
Pest management science.
2023 Jun; 79(6):2040-2049. doi:
10.1002/ps.7378. [PMID: 36693781] - Liuqin He, Yaqiong Ding, Xihong Zhou, Tiejun Li, Yulong Yin. Serine signaling governs metabolic homeostasis and health.
Trends in endocrinology and metabolism: TEM.
2023 06; 34(6):361-372. doi:
10.1016/j.tem.2023.03.001. [PMID: 36967366] - Yun Yang, Yuan Xiong, Guanghao Zhu, Mengru Sun, Kun Zou, Yitian Zhao, Yong Zhang, Zhijian Xu, Yiming Li, Weiliang Zhu, Qi Jia, Bo Li, Guangbo Ge. Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors.
Chemico-biological interactions.
2023 Jun; 378(?):110501. doi:
10.1016/j.cbi.2023.110501. [PMID: 37080375] - Feng-Xia Liu, Yan Sun. Identification of the active ingredients and pharmacological effects of Kuntai capsules in the treatment of primary ovarian insufficiency: A review.
Medicine.
2023 May; 102(21):e33884. doi:
10.1097/md.0000000000033884. [PMID: 37233423] - Justine Lallement, Ilyès Raho, Grégory Merlen, Dominique Rainteau, Mikael Croyal, Melody Schiffano, Nadim Kassis, Isabelle Doignon, Maud Soty, Floriane Lachkar, Michel Krempf, Matthias Van Hul, Patrice D Cani, Fabienne Foufelle, Chloé Amouyal, Hervé Le Stunff, Christophe Magnan, Thierry Tordjmann, Céline Cruciani-Guglielmacci. Hepatic deletion of serine palmitoyl transferase 2 impairs ceramide/sphingomyelin balance, bile acids homeostasis and leads to liver damage in mice.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2023 May; 1868(8):159333. doi:
10.1016/j.bbalip.2023.159333. [PMID: 37224999] - Mingmin Tian, Anming Yang, Qinwei Lu, Xin Zhang, Guangjie Liu, Gaofeng Liu. Study on the mechanism of Baihe Dihuang decoction in treating menopausal syndrome based on network pharmacology.
Medicine.
2023 May; 102(20):e33189. doi:
10.1097/md.0000000000033189. [PMID: 37335709] - A A Zorina, G V Novikova, N B Gusev, A V Leusenko, D A Los, O I Klychnikov. SpkH (Sll0005) from Synechocystis sp. PCC 6803 is an active Mn2+-dependent Ser kinase.
Biochimie.
2023 May; ?(?):. doi:
10.1016/j.biochi.2023.05.006. [PMID: 37209809] - Wang Shunxi, Yuan Xiaoxue, Song Guanbin, Yang Li, Jin Junyu, Liu Wanqian. Serine metabolic reprogramming in tumorigenesis, tumor immunity and clinical treatment: Serine metabolic reprogramming in cancer.
Advances in nutrition (Bethesda, Md.).
2023 May; ?(?):. doi:
10.1016/j.advnut.2023.05.007. [PMID: 37187454] - Shin-Ichi Miyazawa, Tokuko Ujino-Ihara, Takafumi Miyama, Ko Tahara, Hiroyuki Tobita, Yuji Suzuki, Mitsuru Nishiguchi. Different photorespiratory mechanisms in conifer leaves, where peroxisomes have intrinsically low catalase activity.
The Plant journal : for cell and molecular biology.
2023 May; ?(?):. doi:
10.1111/tpj.16276. [PMID: 37162489] - Zi-Chang Jia, Debatosh Das, Youjun Zhang, Alisdair R Fernie, Ying-Gao Liu, Moxian Chen, Jianhua Zhang. Plant serine/arginine-rich proteins: versatile players in RNA processing.
Planta.
2023 May; 257(6):109. doi:
10.1007/s00425-023-04132-0. [PMID: 37145304] - Yong Zhuo, Xiangyang Zou, Ya Wang, Xuemei Jiang, Mengmeng Sun, Shengyu Xu, Yan Lin, Lun Hua, Jian Li, Bin Feng, Zhengfeng Fang, Lianqiang Che, De Wu. Standardized ileal digestibility of amino acids in cottonseed meal fed to pregnant and non-pregnant sows.
Journal of animal science.
2023 Apr; ?(?):. doi:
10.1093/jas/skad132. [PMID: 37119089] - Xiling Zhu, Yan Li, Xiaodong Wang, Yuanshe Huang, Jingxin Mao. Investigation of the mechanism of Prunella vulgaris in treatment of papillary thyroid carcinoma based on network pharmacology integrated molecular docking and experimental verification.
Medicine.
2023 Apr; 102(17):e33360. doi:
10.1097/md.0000000000033360. [PMID: 37115092] - Ajay Guru, Gokul Sudhakaran, S Karthick Raja Namasivayam, Boopathi Seenivasan, Mukesh Pasupulieti, Jesu Arockiaraj, Meivelu Moovendhan. Serine Threonine-Protein Kinase-Derived IW13 Improves Lipid Metabolism via C/EBP-α/SREBP1/FAS Signaling Pathways in HFD-Induced Zebrafish In Vivo Larval Model.
Applied biochemistry and biotechnology.
2023 Apr; ?(?):. doi:
10.1007/s12010-023-04480-3. [PMID: 37079270] - Priya Rawat, Shilpa Thakur, Surbhi Dogra, Kajal Jaswal, Budheswar Dehury, Prosenjit Mondal. Diet-induced induction of hepatic Serine/Threonine Kinase STK38 triggers proinflammation and hepatic lipid accumulation.
The Journal of biological chemistry.
2023 Apr; ?(?):104678. doi:
10.1016/j.jbc.2023.104678. [PMID: 37028764] - Sophia Escobar-Correas, Omar Mendoza-Porras, Alfredo Castro-Vazquez, Israel A Vega, Michelle L Colgrave. Proteomic analysis of digestive tract peptidases and lipases from the invasive gastropod Pomacea canaliculata.
Pest management science.
2023 Apr; 79(4):1420-1430. doi:
10.1002/ps.7311. [PMID: 36464640] - Jing Jing Zhang, Yujia Niu, Cong Ma, Te Zhao, Hongwei Wang, Zishuo Yan, Lin Zhou, Xiangyang Liu, Fengzhi Piao, Nanshan Du. Accumulation and metabolism of pyroxasulfone in tomato seedlings.
Ecotoxicology and environmental safety.
2023 Apr; 254(?):114765. doi:
10.1016/j.ecoenv.2023.114765. [PMID: 36907092] - Shota Suzuki, Daimu Tanaka, Atsuko Miyagi, Kentaro Takahara, Masaru Kono, Chaomurilege, Ko Noguchi, Toshiki Ishikawa, Minoru Nagano, Masatoshi Yamaguchi, Maki Kawai-Yamada. Loss of peroxisomal NAD kinase 3 (NADK3) affects photorespiration metabolism in Arabidopsis.
Journal of plant physiology.
2023 Apr; 283(?):153950. doi:
10.1016/j.jplph.2023.153950. [PMID: 36889102] - Courtney R Green, Roberto Bonelli, Brendan R E Ansell, Simone Tzaridis, Michal K Handzlik, Grace H McGregor, Barbara Hart, Jennifer Trombley, Mary M Reilly, Paul S Bernstein, Catherine Egan, Marcus Fruttiger, Martina Wallace, Melanie Bahlo, Martin Friedlander, Christian M Metallo, Marin L Gantner. Divergent amino acid and sphingolipid metabolism in patients with inherited neuro-retinal disease.
Molecular metabolism.
2023 Mar; ?(?):101716. doi:
10.1016/j.molmet.2023.101716. [PMID: 36997154] - Gints Kalnins, Rebeka Ludviga, Ieva Kalnciema, Gunta Resevica, Vilija Zeltina, Janis Bogans, Kaspars Tars, Andris Zeltins, Ina Balke. VPg Impact on Ryegrass Mottle Virus Serine-like 3C Protease Proteolysis and Structure.
International journal of molecular sciences.
2023 Mar; 24(6):. doi:
10.3390/ijms24065347. [PMID: 36982419] - Feifan Chen, Jianpeng Yong, Gaoyuan Zhang, Mengying Liu, Qiqi Wang, Huili Zhong, Yupeng Pan, Peng Chen, Yiqun Weng, Yuhong Li. An LTR retrotransposon insertion inside CsERECTA for an LRR receptor-like serine/threonine-protein kinase results in compact (cp) plant architecture in cucumber.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik.
2023 Mar; 136(3):31. doi:
10.1007/s00122-023-04273-6. [PMID: 36894705] - Guoqi Yu, Jinguo Wang, Yongjie Liu, Tingyu Luo, Xi Meng, Ruiyuan Zhang, Bo Huang, Yan Sun, Jun Zhang. Metabolic perturbations in pregnant rats exposed to low-dose perfluorooctanesulfonic acid: An integrated multi-omics analysis.
Environment international.
2023 Feb; 173(?):107851. doi:
10.1016/j.envint.2023.107851. [PMID: 36863164] - Marciele da Silva, Layrana Santos, Gabriel Taveira, Celso Nagano, Renata Chaves, Andre Carvalho, Rosana Rodrigues, Valdirene Gomes. Trypsin/α-Amylase Inhibitors from Capsicum chinense Seeds: Characterization and Antifungal Activity Against Fungi of Agronomic Importance.
Protein and peptide letters.
2023 Feb; ?(?):. doi:
10.2174/0929866530666230221141804. [PMID: 36803276] - Yueping Zhu, Qilai Xie, Jinshao Ye, Ruzhen Wang, Xudong Yin, Wenyu Xie, Dehao Li. Metabolic Mechanism of Bacillus sp. LM24 under Abamectin Stress.
International journal of environmental research and public health.
2023 02; 20(4):. doi:
10.3390/ijerph20043068. [PMID: 36833759] - Zenghui Tian, Yanke Hao, Mingliang Wang, Yingying Li, Kaiying Cui, Pengfei Hou, Xiaoying Wang, Dengwan Lv, Jie Shi. Understanding the mechanism of twenty-five ingredient decoction for setting a fracture in the treatment of fractures based on network pharmacology.
Medicine.
2023 Feb; 102(5):e32864. doi:
10.1097/md.0000000000032864. [PMID: 36749277] - Peng Tang, Yong Tang, Yan Liu, Bing He, Xin Shen, Zhi-Jie Zhang, Da-Lian Qin, Ji Tian. Quercetin-3-O-α-L-arabinopyranosyl-(1→2)-β-D-glucopyranoside Isolated from Eucommia ulmoides Leaf Relieves Insulin Resistance in HepG2 Cells via the IRS-1/PI3K/Akt/GSK-3β Pathway.
Biological & pharmaceutical bulletin.
2023 Feb; 46(2):219-229. doi:
10.1248/bpb.b22-00597. [PMID: 36517007] - Yasel Guerra, Vinicio Armijos-Jaramillo, Tirso Pons, Eduardo Tejera, Colin Berry. Canonical or noncanonical? Structural plasticity of serine protease-binding loops in Kunitz-STI protease inhibitors.
Protein science : a publication of the Protein Society.
2023 02; 32(2):e4570. doi:
10.1002/pro.4570. [PMID: 36660780] - Nuha Anajirih, Saoirse E O'Sullivan, Stephen Ph Alexander. Endocannabinoid hydrolases differentially distribute in platelets and red blood cells and are differentially released by thrombin.
Prostaglandins & other lipid mediators.
2023 Feb; 164(?):106692. doi:
10.1016/j.prostaglandins.2022.106692. [PMID: 36372184] - Michal K Handzlik, Jivani M Gengatharan, Katie E Frizzi, Grace H McGregor, Cameron Martino, Gibraan Rahman, Antonio Gonzalez, Ana M Moreno, Courtney R Green, Lucie S Guernsey, Terry Lin, Patrick Tseng, Yoichiro Ideguchi, Regis J Fallon, Amandine Chaix, Satchidananda Panda, Prashant Mali, Martina Wallace, Rob Knight, Marin L Gantner, Nigel A Calcutt, Christian M Metallo. Insulin-regulated serine and lipid metabolism drive peripheral neuropathy.
Nature.
2023 Feb; 614(7946):118-124. doi:
10.1038/s41586-022-05637-6. [PMID: 36697822] - Xiaomu Zhang, Philip J Tubergen, Israel D K Agorsor, Pramod Khadka, Connor Tembe, Cynthia Denbow, Eva Collakova, Guillaume Pilot, Cristian H Danna. Elicitor-induced plant immunity relies on amino acids accumulation to delay the onset of bacterial virulence.
Plant physiology.
2023 Jan; ?(?):. doi:
10.1093/plphys/kiad048. [PMID: 36715647] - Karol Sikora, Marta Bauer, Sylwia Bartoszewska, Damian Neubauer, Wojciech Kamysz. Glycosylated Lipopeptides-Synthesis and Evaluation of Antimicrobial Activity and Cytotoxicity.
Biomolecules.
2023 01; 13(1):. doi:
10.3390/biom13010172. [PMID: 36671557] - Dingding Gao, Shuai Tang, Yixin Cen, Liang Yuan, Xiaojing Lan, Qing-Hua Li, Guo-Qiang Lin, Min Huang, Ping Tian. Discovery of Novel Drug-like PHGDH Inhibitors to Disrupt Serine Biosynthesis for Cancer Therapy.
Journal of medicinal chemistry.
2023 01; 66(1):285-305. doi:
10.1021/acs.jmedchem.2c01202. [PMID: 36594670] - Lanxin Hu, Jinwei Hu, Yanlin Huang, Sihan Zheng, Ji Yin, Xiaohui Li, Daiying Li, Caifeng Lv, Sen Li, Wenjian Hu. Hypoxia-mediated activation of hypoxia-inducible factor-1α in head and neck squamous cell carcinoma: A review.
Medicine.
2023 Jan; 102(1):e32533. doi:
10.1097/md.0000000000032533. [PMID: 36607847] - Zhihui Dai, Lin Chen, KaiLing Pan, XiaoYa Zhao, WenXia Xu, JinLin Du, Chungen Xing. Multi-omics Analysis of the Role of PHGDH in Colon Cancer.
Technology in cancer research & treatment.
2023 Jan; 22(?):15330338221145994. doi:
10.1177/15330338221145994. [PMID: 36707056] - Xinyu Fu, Luke M Gregory, Sean E Weise, Berkley J Walker. Integrated flux and pool size analysis in plant central metabolism reveals unique roles of glycine and serine during photorespiration.
Nature plants.
2023 01; 9(1):169-178. doi:
10.1038/s41477-022-01294-9. [PMID: 36536013] - Qianqian Lu, Xinzhu Zhou, Ruidan Liu, Guojing Shi, Ningning Zheng, Guanghai Gao, Yingying Wang. Impacts of a bacterial algicide on metabolic pathways in Chlorella vulgaris.
Ecotoxicology and environmental safety.
2023 Jan; 249(?):114451. doi:
10.1016/j.ecoenv.2022.114451. [PMID: 38321670] - Jolanta Bugajska, Joanna Berska, Małgorzata Wójcik, Krystyna Sztefko. Amino acid profile in overweight and obese prepubertal children - can simple biochemical tests help in the early prevention of associated comorbidities?.
Frontiers in endocrinology.
2023; 14(?):1274011. doi:
10.3389/fendo.2023.1274011. [PMID: 37964971] - Natascha Berger, Tom van der Wel, Birgit Hirschmugl, Thomas Baernthaler, Juergen Gindlhuber, Nermeen Fawzy, Thomas Eichmann, Ruth Birner-Gruenberger, Robert Zimmermann, Mario van der Stelt, Christian Wadsack. Inhibition of diacylglycerol lipase β modulates lipid and endocannabinoid levels in the ex vivo human placenta.
Frontiers in endocrinology.
2023; 14(?):1092024. doi:
10.3389/fendo.2023.1092024. [PMID: 36864832] - Kwang-Mook Jung, Daniele Piomelli. Assay of Monoacylglycerol Lipase Activity.
Methods in molecular biology (Clifton, N.J.).
2023; 2576(?):285-297. doi:
10.1007/978-1-0716-2728-0_24. [PMID: 36152196] - Hongsheng Yang, Meifang Shen, Qiuyun Zhang, Yifeng Li, Xiuhui Tan, Xuguang Li, Huimin Chen, Lei Wu, Shaofang He, Xiaohua Zhu. Transcriptome and metabolomics analysis of adaptive mechanism of Chinese mitten crab (Eriocheir sinensis) to aflatoxin B1.
PloS one.
2023; 18(12):e0295291. doi:
10.1371/journal.pone.0295291. [PMID: 38060597] - Jiao Xie, Bing Deng, Wenjun Wang, Hongyan Zhang. Changes in sugar, organic acid and free amino acid levels and the expression of genes involved in the primary metabolism of oleocellosis in citrus peels.
Journal of plant physiology.
2023 Jan; 280(?):153877. doi:
10.1016/j.jplph.2022.153877. [PMID: 36436240] - Mozhgan Hashemi, Ahmad Moieni, Mohammad Sadegh Sabet. Improving the isolated microspore culture in eggplant (Solanum melongena L.) with amino acid nutrition.
PloS one.
2023; 18(6):e0286809. doi:
10.1371/journal.pone.0286809. [PMID: 37289731] - Taro Kimura, Ken Haga, Tatsuya Sakai. The phosphorylation status of NONPHOTOTROPIC HYPOCOTYL3 affects phot2-dependent phototropism in Arabidopsis.
Plant signaling & behavior.
2022 12; 17(1):2027138. doi:
10.1080/15592324.2022.2027138. [PMID: 35068333] - Hamed Ramyar, Mehdi Baradaran-Firouzabadi, Ali Reza Sobhani, Hamid Reza Asghari. Reduction of lead toxicity effects and enhancing the glutathione reservoir in green beans through spraying sulfur and serine and glutamine amino acids.
Environmental science and pollution research international.
2022 Dec; ?(?):. doi:
10.1007/s11356-022-24819-3. [PMID: 36576620] - Cristina Razquin, Miguel Ruiz-Canela, Estefania Toledo, Clary B Clish, Marta Guasch-Ferré, Jesús F García-Gavilán, Clemens Wittenbecher, Angel Alonso-Gómez, Montse Fitó, Liming Liang, Dolores Corella, Enrique Gómez-Gracia, Ramon Estruch, Miquel Fiol, Jose M Santos-Lozano, Luis Serra-Majem, Emilio Ros, Fernando Aros, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González. Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial.
International journal of molecular sciences.
2022 Dec; 24(1):. doi:
10.3390/ijms24010270. [PMID: 36613713] - Qingling Zhang, Jubin Wang, Xi Zhang, Yingtian Deng, Feng Li. A Conserved, Serine-Rich Protein Plays Opposite Roles in N-Mediated Immunity against TMV and N-Triggered Cell Death.
Viruses.
2022 12; 15(1):. doi:
10.3390/v15010026. [PMID: 36680066] - Asif Ali, Tingkai Wu, Hongyu Zhang, Peizhou Xu, Syed Adeel Zafar, Yongxiang Liao, Xiaoqiong Chen, Hao Zhou, Yutong Liu, Wenming Wang, Xianjun Wu. A putative SUBTILISIN-LIKE SERINE PROTEASE 1 (SUBSrP1) regulates anther cuticle biosynthesis and panicle development in rice.
Journal of advanced research.
2022 12; 42(?):273-287. doi:
10.1016/j.jare.2022.01.003. [PMID: 36513418] - Hussain Ahmad, Xinrui Zhao, Nisar Ahmad, Abbas Khan, Yuexin Jin, Jie Du, Xuewei Zheng, Li Zeng, Yanan Ouyang, Pengfei Yang, Meng Chen, Xiaoxue Li, Zhe Yang, Zhongmin Tian. Benincasa hispida extracts positively regulated high salt-induced hypertension in Dahl salt-sensitive rats: Impact on biochemical profile and metabolic patterns.
Journal of food biochemistry.
2022 12; 46(12):e14497. doi:
10.1111/jfbc.14497. [PMID: 36314446] - Yuebi Chen, Xiaotian Chen, Xueyou Li, Yue Liu, Yusong Guo, Zhongduo Wang, Zhongdian Dong. Effects of bisphenol AF on growth, behavior, histology and gene expression in marine medaka (Oryzias melastigma).
Chemosphere.
2022 Dec; 308(Pt 3):136424. doi:
10.1016/j.chemosphere.2022.136424. [PMID: 36116629] - Ashis Sarkar, Nirmali Gogoi, Swarnendu Roy. Bisphenol-A incite dose-dependent dissimilitude in the growth pattern, physiology, oxidative status, and metabolite profile of Azolla filiculoides.
Environmental science and pollution research international.
2022 Dec; 29(60):91325-91344. doi:
10.1007/s11356-022-22107-8. [PMID: 35896871]